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Daniel M. Rosenbaum, Ph.D. - Publications

Affiliations: 
2005 Harvard University, Cambridge, MA, United States 
Area:
The Chemistry of Molecular Evolution
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45 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Wang W, Ranjan A, Zhang W, Liang Q, MacMillan KS, Chapman K, Wang X, Chandrasekaran P, Williams NS, Rosenbaum DM, De Brabander JK. Novel orexin receptor agonists based on arene- or pyridine-fused 1,3-dihydro-2H-imidazole-2-imines. Bioorganic & Medicinal Chemistry Letters. 99: 129624. PMID 38272190 DOI: 10.1016/j.bmcl.2024.129624  0.313
2023 Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, ... Rosenbaum DM, et al. Reply to: The G protein preference of orexin receptors is currently an unresolved issue. Nature Communications. 14: 3163. PMID 37264001 DOI: 10.1038/s41467-023-38765-2  0.305
2023 Kumari P, Inoue A, Chapman K, Lian P, Rosenbaum DM. Molecular mechanism of fatty acid activation of FFAR1. Proceedings of the National Academy of Sciences of the United States of America. 120: e2219569120. PMID 37216523 DOI: 10.1073/pnas.2219569120  0.363
2022 Yin J, Kang Y, McGrath AP, Chapman K, Sjodt M, Kimura E, Okabe A, Koike T, Miyanohana Y, Shimizu Y, Rallabandi R, Lian P, Bai X, Flinspach M, De Brabander JK, ... Rosenbaum DM, et al. Molecular mechanism of the wake-promoting agent TAK-925. Nature Communications. 13: 2902. PMID 35614071 DOI: 10.1038/s41467-022-30601-3  0.402
2021 Ramesh K, Rosenbaum DM. Molecular basis for ligand modulation of the cannabinoid receptor CB1. British Journal of Pharmacology. PMID 34265078 DOI: 10.1111/bph.15627  0.416
2021 Ramesh K, Rosenbaum DM. Molecular basis for ligand modulation of the cannabinoid receptor CB1. British Journal of Pharmacology. PMID 34265078 DOI: 10.1111/bph.15627  0.416
2021 Kober DL, Radhakrishnan A, Goldstein JL, Brown MS, Clark LD, Bai XC, Rosenbaum DM. Scap structures highlight key role for rotation of intertwined luminal loops in cholesterol sensing. Cell. PMID 34139175 DOI: 10.1016/j.cell.2021.05.019  0.605
2021 Xiao P, Yan W, Gou L, Zhong YN, Kong L, Wu C, Wen X, Yuan Y, Cao S, Qu C, Yang X, Yang CC, Xia A, Hu Z, Zhang Q, ... ... Rosenbaum DM, et al. Ligand recognition and allosteric regulation of DRD1-Gs signaling complexes. Cell. PMID 33571432 DOI: 10.1016/j.cell.2021.01.028  0.374
2020 Gunera J, Baker JG, van Hilten N, Rosenbaum DM, Kolb P. Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor. Journal of Medicinal Chemistry. PMID 32977721 DOI: 10.1021/acs.jmedchem.0c00964  0.426
2020 Hellmann J, Drabek M, Yin J, Gunera J, Pröll T, Kraus F, Langmead CJ, Hübner H, Weikert D, Kolb P, Rosenbaum DM, Gmeiner P. Structure-based development of a subtype-selective orexin 1 receptor antagonist. Proceedings of the National Academy of Sciences of the United States of America. PMID 32669442 DOI: 10.1073/Pnas.2002704117  0.503
2020 Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM. Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane. Nature. PMID 32528175 DOI: 10.1038/S41586-020-2379-5  0.491
2019 Shao Z, Yan W, Chapman K, Ramesh K, Ferrell AJ, Yin J, Wang X, Xu Q, Rosenbaum DM. Structure of an allosteric modulator bound to the CB1 cannabinoid receptor. Nature Chemical Biology. PMID 31659318 DOI: 10.1038/S41589-019-0387-2  0.539
2019 Ali R, Clark LD, Zahm JA, Lemoff A, Ramesh K, Rosenbaum DM, Rosen MK. Improved strategy for isoleucine H/C methyl labeling in Pichia pastoris. Journal of Biomolecular Nmr. PMID 31541396 DOI: 10.1007/S10858-019-00281-1  0.635
2019 Uchański T, Zögg T, Yin J, Yuan D, Wohlkönig A, Fischer B, Rosenbaum DM, Kobilka BK, Pardon E, Steyaert J. An improved yeast surface display platform for the screening of nanobody immune libraries. Scientific Reports. 9: 382. PMID 30674983 DOI: 10.1038/S41598-018-37212-3  0.483
2019 Dikiy I, Clark LD, Gardner KH, Rosenbaum DM. Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics. Methods in Enzymology. 614: 37-65. PMID 30611431 DOI: 10.1016/Bs.Mie.2018.08.030  0.668
2018 Yin J, Chapman K, Clark LD, Shao Z, Borek D, Xu Q, Wang J, Rosenbaum DM. Crystal structure of the human NK tachykinin receptor. Proceedings of the National Academy of Sciences of the United States of America. PMID 30538204 DOI: 10.1073/Pnas.1812717115  0.712
2018 Clark L, Dikiy I, Rosenbaum DM, Gardner KH. On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies. Journal of Biomolecular Nmr. PMID 30121871 DOI: 10.1007/S10858-018-0204-3  0.682
2017 Suno R, Kimura KT, Nakane T, Yamashita K, Wang J, Fujiwara T, Yamanaka Y, Im D, Horita S, Tsujimoto H, Tawaramoto MS, Hirokawa T, Nango E, Tono K, Kameshima T, ... ... Rosenbaum DM, et al. Crystal Structures of Human Orexin 2 Receptor Bound to the Subtype-Selective Antagonist EMPA. Structure (London, England : 1993). PMID 29225076 DOI: 10.1016/J.Str.2017.11.005  0.46
2017 Clark LD, Dikiy I, Chapman K, Rödström KEJ, Aramini J, LeVine MV, Khelashvili G, Rasmussen SGF, Gardner KH, Rosenbaum DM. Ligand modulation of sidechain dynamics in a wild-type human GPCR. Elife. 6. PMID 28984574 DOI: 10.1016/J.Bpj.2017.11.1330  0.703
2017 Lee JY, Rosenbaum DM. Transporters Revealed. Cell. 168: 951-953. PMID 28283067 DOI: 10.1016/j.cell.2017.02.033  0.513
2017 Clark LD, Dikiy I, Chapman K, Rödström KE, Aramini J, LeVine MV, Khelashvili G, Rasmussen SG, Gardner KH, Rosenbaum DM. Author response: Ligand modulation of sidechain dynamics in a wild-type human GPCR Elife. DOI: 10.7554/Elife.28505.028  0.614
2017 Lee J(, Rosenbaum D, Hobbs H. Structural Role of ABCG5/ABCG8 in Sterol Transport Biophysical Journal. 112: 22a. DOI: 10.1016/J.Bpj.2016.11.153  0.676
2016 Yin J, Rosenbaum DM. The Human Orexin/Hypocretin Receptor Crystal Structures. Current Topics in Behavioral Neurosciences. PMID 28025809 DOI: 10.1007/7854_2016_52  0.526
2016 Shao Z, Yin J, Chapman K, Grzemska M, Clark L, Wang J, Rosenbaum DM. High-resolution crystal structure of the human CB1 cannabinoid receptor. Nature. PMID 27851727 DOI: 10.1038/Nature20613  0.724
2016 Lee JY, Kinch LN, Borek DM, Wang J, Wang J, Urbatsch IL, Xie XS, Grishin NV, Cohen JC, Otwinowski Z, Hobbs HH, Rosenbaum DM. Crystal structure of the human sterol transporter ABCG5/ABCG8. Nature. PMID 27144356 DOI: 10.1038/Nature17666  0.688
2016 Zhang Y, Lee KM, Kinch LN, Clark L, Grishin NV, Rosenbaum DM, Brown MS, Goldstein JL, Radhakrishnan A. Direct Demonstration that Loop1 of Scap Binds to Loop7, a crucial event in cholesterol homeostasis. The Journal of Biological Chemistry. PMID 27068746 DOI: 10.1074/Jbc.M116.729798  0.649
2016 Yin J, Babaoglu K, Brautigam CA, Clark L, Shao Z, Scheuermann TH, Harrell CM, Gotter AL, Roecker AJ, Winrow CJ, Renger JJ, Coleman PJ, Rosenbaum DM. Structure and ligand-binding mechanism of the human OX1 and OX2 orexin receptors. Nature Structural & Molecular Biology. PMID 26950369 DOI: 10.1038/Nsmb.3183  0.709
2016 Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM. Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris. Journal of Biomolecular Nmr. PMID 26894386 DOI: 10.1007/S10858-016-0016-2  0.557
2015 Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM. Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris. Journal of Biomolecular Nmr. 62: 239-45. PMID 26025061 DOI: 10.1007/S10858-015-9939-2  0.619
2015 Yin J, Mobarec JC, Kolb P, Rosenbaum DM. Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant. Nature. 519: 247-50. PMID 25533960 DOI: 10.1038/Nature14035  0.547
2012 Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK. Structure and dynamics of the M3 muscarinic acetylcholine receptor. Nature. 482: 552-6. PMID 22358844 DOI: 10.1038/Nature10867  0.644
2011 Rosenbaum DM, Zhang C, Lyons JA, Holl R, Aragao D, Arlow DH, Rasmussen SG, Choi HJ, Devree BT, Sunahara RK, Chae PS, Gellman SH, Dror RO, Shaw DE, Weis WI, et al. Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature. 469: 236-40. PMID 21228876 DOI: 10.1038/Nature09665  0.686
2011 Rasmussen SG, Choi HJ, Fung JJ, Pardon E, Casarosa P, Chae PS, Devree BT, Rosenbaum DM, Thian FS, Kobilka TS, Schnapp A, Konetzki I, Sunahara RK, Gellman SH, Pautsch A, et al. Structure of a nanobody-stabilized active state of the β(2) adrenoceptor. Nature. 469: 175-80. PMID 21228869 DOI: 10.1038/Nature09648  0.732
2010 Bokoch MP, Zou Y, Rasmussen SG, Liu CW, Nygaard R, Rosenbaum DM, Fung JJ, Choi HJ, Thian FS, Kobilka TS, Puglisi JD, Weis WI, Pardo L, Prosser RS, Mueller L, et al. Ligand-specific regulation of the extracellular surface of a G-protein-coupled receptor. Nature. 463: 108-12. PMID 20054398 DOI: 10.1038/Nature08650  0.747
2010 Rosenbaum DM, Rasmussen SGF, Kobilka BK. The γ2 adrenergic receptor as a model for g-protein-coupled receptor structure and activation by diffusible hormones Handbook of Cell Signaling, 2/E. 1: 163-169. DOI: 10.1016/B978-0-12-374145-5.00025-5  0.572
2009 Rosenbaum DM, Rasmussen SG, Kobilka BK. The structure and function of G-protein-coupled receptors. Nature. 459: 356-63. PMID 19458711 DOI: 10.1038/Nature08144  0.64
2009 Kolb P, Rosenbaum DM, Irwin JJ, Fung JJ, Kobilka BK, Shoichet BK. Structure-based discovery of beta2-adrenergic receptor ligands. Proceedings of the National Academy of Sciences of the United States of America. 106: 6843-8. PMID 19342484 DOI: 10.1073/Pnas.0812657106  0.715
2009 Weis WI, Rosenbaum DM, Rasmussen SGF, Choi HJ, Thian FS, Kobilka TS, Yao XJ, Day PW, Parnot C, Fung JJ, Ratnala VRP, Kobilka BK, Cherezov V, Hanson MA, Kuhn P, et al. Crystal structures of the β2-adrenergic receptor Nato Science For Peace and Security Series a: Chemistry and Biology. 217-230. DOI: 10.1007/978-90-481-2339-1-14  0.657
2009 Weis WI, Rosenbaum DM, Rasmussen SGF, Choi HJ, Thian FS, Kobilka TS, Yao XJ, Day PW, Parnot C, Fung JJ, Ratnala VRP, Kobilka BK, Cherezov V, Hanson MA, Kuhn P, et al. Crystal structures of the β2-adrenergic receptor Nato Science For Peace and Security Series a: Chemistry and Biology. 217-230.  0.657
2007 Cherezov V, Rosenbaum DM, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Kuhn P, Weis WI, Kobilka BK, Stevens RC. High-resolution crystal structure of an engineered human beta2-adrenergic G protein-coupled receptor. Science (New York, N.Y.). 318: 1258-65. PMID 17962520 DOI: 10.1126/Science.1150577  0.678
2007 Rosenbaum DM, Cherezov V, Hanson MA, Rasmussen SG, Thian FS, Kobilka TS, Choi HJ, Yao XJ, Weis WI, Stevens RC, Kobilka BK. GPCR engineering yields high-resolution structural insights into beta2-adrenergic receptor function. Science (New York, N.Y.). 318: 1266-73. PMID 17962519 DOI: 10.1126/Science.1150609  0.673
2007 Rasmussen SG, Choi HJ, Rosenbaum DM, Kobilka TS, Thian FS, Edwards PC, Burghammer M, Ratnala VR, Sanishvili R, Fischetti RF, Schertler GF, Weis WI, Kobilka BK. Crystal structure of the human beta2 adrenergic G-protein-coupled receptor. Nature. 450: 383-7. PMID 17952055 DOI: 10.1038/Nature06325  0.652
2006 Phillips KJ, Rosenbaum DM, Liu DR. Binding and stability determinants of the PPARgamma nuclear receptor-coactivator interface as revealed by shotgun alanine scanning and in vivo selection. Journal of the American Chemical Society. 128: 11298-306. PMID 16925449 DOI: 10.1021/Ja0635985  0.723
2003 Rosenbaum DM, Liu DR. Efficient and sequence-specific DNA-templated polymerization of peptide nucleic acid aldehydes. Journal of the American Chemical Society. 125: 13924-5. PMID 14611205 DOI: 10.1021/Ja038058B  0.39
1999 Rosenbaum DM, Roy S, Hecht MH. Screening combinatorial libraries of de Novo proteins by hydrogen- deuterium exchange and electrospray mass spectrometry Journal of the American Chemical Society. 121: 9509-9513. DOI: 10.1021/Ja991843X  0.342
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