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Kevin H. Gardner - Publications

Affiliations: 
Structural Biology Initiative CUNY Advanced Science Research Center 
Website:
http://kglab.org
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135 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Cleere MM, Gardner KH. Optogenetic control of phosphate-responsive genes using single component fusion proteins in . Biorxiv : the Preprint Server For Biology. PMID 39131330 DOI: 10.1101/2024.08.02.605841  0.815
2024 Xu X, Closson JD, Marcelino LP, Favaro DC, Silvestrini ML, Solazzo R, Chong LT, Gardner KH. Identification of Small Molecule Ligand Binding Sites On and In the ARNT PAS-B Domain. The Journal of Biological Chemistry. 107606. PMID 39059491 DOI: 10.1016/j.jbc.2024.107606  0.68
2024 Xiao M, Dhungel S, Azad R, Favaro DC, Rajesh RP, Gardner KH, Kikani CK. Signal-regulated Unmasking of Nuclear Localization Motif in the PAS Domain Regulates the Nuclear Translocation of PASK. Journal of Molecular Biology. 168433. PMID 38182104 DOI: 10.1016/j.jmb.2023.168433  0.338
2023 Xu X, Marcelino LP, Favaro DC, Silvestrini ML, Solazzo R, Chong LT, Gardner KH. Identification of Small Molecule Ligand Binding Sites On and In the ARNT PAS-B Domain. Biorxiv : the Preprint Server For Biology. PMID 37961463 DOI: 10.1101/2023.11.03.565595  0.679
2023 Xiao M, Dhungel S, Azad R, Favaro D, Rajesh RP, Gardner KH, Kikani CK. Signal-regulated unmasking of the nuclear localization motif in the PAS domain regulates the nuclear translocation of PASK. Biorxiv : the Preprint Server For Biology. PMID 37732199 DOI: 10.1101/2023.09.06.556462  0.341
2023 Dikiy I, Swingle D, Toy K, Edupuganti UR, Rivera-Cancel G, Gardner KH. Diversity of function and higher-order structure within HWE sensor histidine kinases. The Journal of Biological Chemistry. 104934. PMID 37331599 DOI: 10.1016/j.jbc.2023.104934  0.775
2022 Berlew EE, Yamada K, Kuznetsov IA, Rand EA, Ochs CC, Jaber Z, Gardner KH, Chow BY. Designing Single-Component Optogenetic Membrane Recruitment Systems: The Rho-Family GTPase Signaling Toolbox. Acs Synthetic Biology. 11: 515-521. PMID 34978789 DOI: 10.1021/acssynbio.1c00604  0.794
2021 Xu X, Dikiy I, Evans MR, Marcelino LP, Gardner KH. Fragile protein folds: Sequence and environmental factors affecting the equilibrium of two interconverting, stably folded protein conformations. Magnetic Resonance (Gottingen, Germany). 2: 63-76. PMID 35603043 DOI: 10.5194/mr-2-63-2021  0.82
2021 Siclari JJ, Gardner KH. Two steps, one ligand: How PPARγ binds small-molecule agonists. Structure (London, England : 1993). 29: 935-936. PMID 34478635 DOI: 10.1016/j.str.2021.08.005  0.766
2021 Hart JE, Gardner KH. Lighting the way: Recent insights into the structure and regulation of phototropin blue light receptors. The Journal of Biological Chemistry. 100594. PMID 33781746 DOI: 10.1016/j.jbc.2021.100594  0.819
2021 LaBelle J, Ramos-Martinez A, Shen K, Motta-Mena LB, Gardner KH, Materna SC, Woo S. TAEL 2.0: An Improved Optogenetic Expression System for Zebrafish. Zebrafish. 20-28. PMID 33555975 DOI: 10.1089/zeb.2020.1951  0.784
2021 Xu X, Gagné D, Aramini JM, Gardner KH. Volume and Compressibility Differences Between Protein Conformations Revealed by High-Pressure NMR. Biophysical Journal. PMID 33524371 DOI: 10.1016/j.bpj.2020.12.034  0.781
2020 Iuliano JN, Tolentino Collado J, Gil AA, Ravindran PT, Lukacs A, Shin S, Woroniecka HA, Adamczyk K, Aramini JM, Edupuganti UR, Hall CR, Greetham GM, Sazanovich IV, Clark IP, Daryaee T, ... ... Gardner KH, et al. Unraveling the Mechanism of a LOV Domain Optogenetic Sensor: A Glutamine Lever Induces Unfolding of the Jα Helix. Acs Chemical Biology. PMID 32880430 DOI: 10.1021/Acschembio.0C00543  0.82
2020 Gardner KH. Decision letter: Multi-state recognition pathway of the intrinsically disordered protein kinase inhibitor by protein kinase A Elife. DOI: 10.7554/Elife.55607.Sa1  0.309
2019 Dikiy I, Gardner KH. Shining light on the alphaproteobacterial general stress response: Comment on: Fiebig et al., Mol Microbiol, 2019. Molecular Microbiology. PMID 31120626 DOI: 10.1111/Mmi.14311  0.675
2019 Dikiy I, Edupuganti UR, Abzalimov RR, Borbat PP, Srivastava M, Freed JH, Gardner KH. Insights into histidine kinase activation mechanisms from the monomeric blue light sensor EL346. Proceedings of the National Academy of Sciences of the United States of America. PMID 30808807 DOI: 10.1073/Pnas.1813586116  0.814
2019 Dikiy I, Clark LD, Gardner KH, Rosenbaum DM. Isotopic Labeling of Eukaryotic Membrane Proteins for NMR Studies of Interactions and Dynamics. Methods in Enzymology. 614: 37-65. PMID 30611431 DOI: 10.1016/Bs.Mie.2018.08.030  0.704
2018 Clark L, Dikiy I, Rosenbaum DM, Gardner KH. On the use of Pichia pastoris for isotopic labeling of human GPCRs for NMR studies. Journal of Biomolecular Nmr. PMID 30121871 DOI: 10.1007/S10858-018-0204-3  0.705
2018 Glantz ST, Berlew EE, Jaber Z, Schuster BS, Gardner KH, Chow BY. Directly light-regulated binding of RGS-LOV photoreceptors to anionic membrane phospholipids. Proceedings of the National Academy of Sciences of the United States of America. PMID 30065115 DOI: 10.1073/Pnas.1802832115  0.811
2018 Losi A, Gardner KH, Möglich A. Blue-Light Receptors for Optogenetics. Chemical Reviews. PMID 29984995 DOI: 10.1021/Acs.Chemrev.8B00163  0.37
2017 Clark LD, Dikiy I, Chapman K, Rödström KEJ, Aramini J, LeVine MV, Khelashvili G, Rasmussen SGF, Gardner KH, Rosenbaum DM. Ligand modulation of sidechain dynamics in a wild-type human GPCR. Elife. 6. PMID 28984574 DOI: 10.1016/J.Bpj.2017.11.1330  0.705
2017 Clark LD, Dikiy I, Chapman K, Rödström KE, Aramini J, LeVine MV, Khelashvili G, Rasmussen SG, Gardner KH, Rosenbaum DM. Author response: Ligand modulation of sidechain dynamics in a wild-type human GPCR Elife. DOI: 10.7554/Elife.28505.028  0.651
2016 Reade A, Motta-Mena LB, Gardner KH, Stainier DY, Weiner OD, Woo S. TAEL: A zebrafish-optimized optogenetic gene expression system with fine spatial and temporal control. Development (Cambridge, England). PMID 27993986 DOI: 10.1242/Dev.139238  0.775
2016 Corrêa F, Key J, Kuhlman B, Gardner KH. Computational Repacking of HIF-2α Cavity Replaces Water-Based Stabilized Core. Structure (London, England : 1993). PMID 27667693 DOI: 10.1016/J.Str.2016.08.014  0.736
2016 Corrêa F, Gardner KH. Basis of Mutual Domain Inhibition in a Bacterial Response Regulator. Cell Chemical Biology. PMID 27524295 DOI: 10.1016/J.Chembiol.2016.07.010  0.676
2016 Glantz ST, Carpenter EJ, Melkonian M, Gardner KH, Boyden ES, Wong GK, Chow BY. Functional and topological diversity of LOV domain photoreceptors. Proceedings of the National Academy of Sciences of the United States of America. PMID 26929367 DOI: 10.1073/Pnas.1509428113  0.446
2016 Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM. Erratum to: Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris. Journal of Biomolecular Nmr. PMID 26894386 DOI: 10.1007/S10858-016-0016-2  0.474
2015 Scheuermann TH, Padrick SB, Gardner KH, Brautigam CA. On the acquisition and analysis of microscale thermophoresis data. Analytical Biochemistry. PMID 26739938 DOI: 10.1016/J.Ab.2015.12.013  0.793
2015 Scheuermann TH, Stroud D, Sleet CE, Bayeh L, Shokri C, Wang H, Caldwell CG, Longgood J, MacMillan JB, Bruick RK, Gardner KH, Tambar UK. Isoform-Selective and Stereoselective Inhibition of Hypoxia Inducible Factor-2. Journal of Medicinal Chemistry. PMID 26226049 DOI: 10.1021/Acs.Jmedchem.5B00529  0.814
2015 Clark L, Zahm JA, Ali R, Kukula M, Bian L, Patrie SM, Gardner KH, Rosen MK, Rosenbaum DM. Methyl labeling and TROSY NMR spectroscopy of proteins expressed in the eukaryote Pichia pastoris. Journal of Biomolecular Nmr. 62: 239-45. PMID 26025061 DOI: 10.1007/S10858-015-9939-2  0.564
2015 Ocasio VJ, Corrêa F, Gardner KH. Ligand-induced folding of a two-component signaling receiver domain. Biochemistry. 54: 1353-63. PMID 25629646 DOI: 10.1021/Bi501143B  0.479
2015 Guo Y, Scheuermann TH, Partch CL, Tomchick DR, Gardner KH. Coiled-coil coactivators play a structural role mediating interactions in hypoxia-inducible factor heterodimerization. The Journal of Biological Chemistry. 290: 7707-21. PMID 25627682 DOI: 10.1074/Jbc.M114.632786  0.817
2014 Rivera-Cancel G, Ko WH, Tomchick DR, Correa F, Gardner KH. Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation. Proceedings of the National Academy of Sciences of the United States of America. 111: 17839-44. PMID 25468971 DOI: 10.1073/Pnas.1413983111  0.818
2014 Motta-Mena LB, Reade A, Mallory MJ, Glantz S, Weiner OD, Lynch KW, Gardner KH. An optogenetic gene expression system with rapid activation and deactivation kinetics Nature Chemical Biology. 10: 196-202. PMID 24413462 DOI: 10.1038/Nchembio.1430  0.803
2013 Salomon D, Guo Y, Kinch LN, Grishin NV, Gardner KH, Orth K. Effectors of animal and plant pathogens use a common domain to bind host phosphoinositides. Nature Communications. 4: 2973. PMID 24346350 DOI: 10.1038/Ncomms3973  0.713
2013 Zoltowski BD, Motta-Mena LB, Gardner KH. Blue light-induced dimerization of a bacterial LOV-HTH DNA-binding protein Biochemistry. 52: 6653-6661. PMID 23992349 DOI: 10.1021/Bi401040M  0.814
2013 Correa F, Ko WH, Ocasio V, Bogomolni RA, Gardner KH. Blue light regulated two-component systems: Enzymatic and functional analyses of light-oxygen-voltage (LOV)-histidine kinases and downstream response regulators Biochemistry. 52: 4656-4666. PMID 23806044 DOI: 10.1021/Bi400617Y  0.78
2013 Scheuermann TH, Li Q, Ma HW, Key J, Zhang L, Chen R, Garcia JA, Naidoo J, Longgood J, Frantz DE, Tambar UK, Gardner KH, Bruick RK. Allosteric inhibition of hypoxia inducible factor-2 with small molecules. Nature Chemical Biology. 9: 271-6. PMID 23434853 DOI: 10.1038/Nchembio.1185  0.806
2013 Freddolino PL, Gardner KH, Schulten K. Signaling mechanisms of LOV domains: new insights from molecular dynamics studies. Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society For Photobiology. 12: 1158-70. PMID 23407663 DOI: 10.1039/C3Pp25400C  0.497
2013 Moon TM, Correa F, Kinch LN, Piala AT, Gardner KH, Goldsmith EJ. Solution structure of the WNK1 autoinhibitory domain, a WNK-specific PF2 domain Journal of Molecular Biology. 425: 1245-1252. PMID 23376100 DOI: 10.1016/J.Jmb.2013.01.031  0.653
2013 Rogers JL, Bayeh L, Scheuermann TH, Longgood J, Key J, Naidoo J, Melito L, Shokri C, Frantz DE, Bruick RK, Gardner KH, MacMillan JB, Tambar UK. Development of inhibitors of the PAS-B domain of the HIF-2α transcription factor. Journal of Medicinal Chemistry. 56: 1739-47. PMID 23363003 DOI: 10.1021/Jm301847Z  0.815
2013 Guo Y, Partch CL, Key J, Card PB, Pashkov V, Patel A, Bruick RK, Wurdak H, Gardner KH. Regulating the ARNT/TACC3 axis: multiple approaches to manipulating protein/protein interactions with small molecules. Acs Chemical Biology. 8: 626-35. PMID 23240775 DOI: 10.1021/Cb300604U  0.807
2012 Rivera-Cancel G, Motta-Mena LB, Gardner KH. Identification of natural and artificial DNA substrates for light-activated LOV-HTH transcription factor EL222 Biochemistry. 51: 10024-10034. PMID 23205774 DOI: 10.1021/Bi301306T  0.828
2012 Markley JL, Akutsu H, Asakura T, Baldus M, Boelens R, Bonvin A, Kaptein R, Bax A, Bezsonova I, Gryk MR, Hoch JC, Korzhnev DM, Maciejewski MW, Case D, Chazin WJ, ... ... Gardner K, et al. In support of the BMRB. Nature Structural & Molecular Biology. 19: 854-60. PMID 22955930 DOI: 10.1038/Nsmb.2371  0.69
2012 Moiola C, De Luca P, Cotignola J, Gardner K, Vazquez E, De Siervi A. Dynamic coregulatory complex containing BRCA1, E2F1 and CtIP controls ATM transcription. Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 30: 596-608. PMID 22832221 DOI: 10.1159/000341441  0.365
2012 Rizo J, Rosen MK, Gardner KH. Enlightening molecular mechanisms through study of protein interactions Journal of Molecular Cell Biology. 4: 270-283. PMID 22735643 DOI: 10.1093/Jmcb/Mjs036  0.579
2012 Chollangi S, Thompson JW, Ruiz JC, Gardner KH, Bruick RK. Hemerythrin-like domain within F-box and leucine-rich repeat protein 5 (FBXL5) communicates cellular iron and oxygen availability by distinct mechanisms. The Journal of Biological Chemistry. 287: 23710-7. PMID 22648410 DOI: 10.1074/Jbc.M112.360404  0.335
2012 Gardner KH, Correa F. How plants see the invisible Science. 335: 1451-1452. PMID 22442470 DOI: 10.1126/Science.1220248  0.593
2012 Moon T, Correa F, Gardner K, Goldsmith E. Solution Structure of the WNK1 Autoinhibitory Domain Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Lru/Pdb  0.6
2012 Nash AI, McNulty R, Shillito ME, Swartz TE, Bogomolni RA, Luecke H, Gardner KH. Structural basis of photosensitivity in a bacterial light-oxygen-voltage/ helix-turn-helix (LOV-HTH) DNA-binding protein (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 23 (9449-9454) DOI: 10.1073/pnas.1100262108) Proceedings of the National Academy of Sciences of the United States of America. 109: 5904. DOI: 10.1073/Pnas.1204100109  0.765
2012 Gardner KH, Motta-Mena LB, Zoltowski BD. Biophysical Studies of Natural Photoreceptors: Application to Optogenetic Tool Optimization Biophysical Journal. 102: 40a-41a. DOI: 10.1016/J.Bpj.2011.11.251  0.831
2011 Gardner KH, Mittermaier A, Mulder FAA. Special issue as a tribute to Lewis E Kay on his 50th birthday. Journal of Biomolecular Nmr. 51: 3-207. PMID 21947910 DOI: 10.1007/S10858-011-9561-X  0.643
2011 Zoltowski BD, Nash AI, Gardner KH. Variations in protein-flavin hydrogen bonding in a light, oxygen, voltage domain produce non-Arrhenius kinetics of adduct decay. Biochemistry. 50: 8771-9. PMID 21923139 DOI: 10.1021/Bi200976A  0.829
2011 Yuan H, Dragnea V, Wu Q, Gardner KH, Bauer CE. Mutational and structural studies of the PixD BLUF output signal that affects light-regulated interactions with PixE Biochemistry. 50: 6365-6375. PMID 21688827 DOI: 10.1021/Bi200701D  0.442
2011 Nash AI, McNulty R, Shillito ME, Swartz TE, Bogomolni RA, Luecke H, Gardner KH. Structural basis of photosensitivity in a bacterial light-oxygen-voltage/helix-turn-helix (LOV-HTH) DNA-binding protein. Proceedings of the National Academy of Sciences of the United States of America. 108: 9449-54. PMID 21606338 DOI: 10.1073/Pnas.1100262108  0.811
2011 Partch CL, Gardner KH. Coactivators necessary for transcriptional output of the hypoxia inducible factor, HIF, are directly recruited by ARNT PAS-B. Proceedings of the National Academy of Sciences of the United States of America. 108: 7739-44. PMID 21512126 DOI: 10.1073/Pnas.1101357108  0.712
2011 Song SH, Freddolino PL, Nash AI, Carroll EC, Schulten K, Gardner KH, Larsen DS. Modulating LOV domain photodynamics with a residue alteration outside the chromophore binding site. Biochemistry. 50: 2411-23. PMID 21323358 DOI: 10.1021/Bi200198X  0.804
2011 Zoltowski BD, Gardner KH. Tripping the light fantastic: Blue-light photoreceptors as examples of environmentally modulated protein-protein interactions Biochemistry. 50: 4-16. PMID 21141905 DOI: 10.1021/Bi101665S  0.719
2011 Bruick RK, Gardner KH, MacMillan J, Tambar U. Modulation of HIF-2 Function with Small Molecules: Did Nature Beat Us to It? Blood. 118: SCI-39-SCI-39. DOI: 10.1182/Blood.V118.21.Sci-39.Sci-39  0.454
2011 Di L, Fernandez A, Gardner K. Abstract 226: Transcriptional control of the BRCA1 expression by a metabolic switch Cancer Research. 71: 226-226. DOI: 10.1158/1538-7445.Am2011-226  0.323
2011 Luca PD, Moiola C, Zalazar F, Gueron G, Cotignola J, Vazquez E, Gardner K, Siervi AD. Abstract 2160: Critical BRCA1 role as a transcriptional regulator in prostate cancer DNA damage response Cancer Research. 71: 2160-2160. DOI: 10.1158/1538-7445.Am2011-2160  0.303
2011 Gardner KH. Ligand-Regulated Protein/Protein Interactions: A Versatile Way to Build an Environmental Sensor Biophysical Journal. 100: 26a. DOI: 10.1016/J.Bpj.2010.12.349  0.528
2011 Gardner KH, Mittermaier A, Mulder FAA. A tribute to Lewis e Kay on his 50th birthday Journal of Biomolecular Nmr. 51: 3-4. DOI: 10.1007/s10858-011-9561-x  0.516
2010 Motta-Mena LB, Partch CL, Gardner KH. The three Rs of transcription: recruit, retain, and recycle. Molecular Cell. 40: 855-8. PMID 21172650 DOI: 10.1016/J.Molcel.2010.12.010  0.787
2010 Akella R, Min X, Wu Q, Gardner KH, Goldsmith EJ. The third conformation of p38α MAP kinase observed in phosphorylated p38α and in solution Structure. 18: 1571-1578. PMID 21134636 DOI: 10.1016/J.Str.2010.09.015  0.42
2010 Strickland D, Yao X, Gawlak G, Rosen MK, Gardner KH, Sosnick TR. Rationally improving LOV domain-based photoswitches. Nature Methods. 7: 623-6. PMID 20562867 DOI: 10.1038/Nmeth.1473  0.593
2010 Lehotzky RE, Partch CL, Mukherjee S, Cash HL, Goldman WE, Gardner KH, Hooper LV. Molecular basis for peptidoglycan recognition by a bactericidal lectin. Proceedings of the National Academy of Sciences of the United States of America. 107: 7722-7. PMID 20382864 DOI: 10.1073/Pnas.0909449107  0.657
2010 Partch CL, Gardner KH. Coactivator recruitment: a new role for PAS domains in transcriptional regulation by the bHLH-PAS family. Journal of Cellular Physiology. 223: 553-7. PMID 20112293 DOI: 10.1002/Jcp.22067  0.702
2010 Fernandez AG, Di L, Byun J, Fufa T, Gardner K. Abstract 2941: Rapid changes in chromatin structure in response to extracellular signals Cancer Research. 70: 2941-2941. DOI: 10.1158/1538-7445.Am10-2941  0.301
2010 Di L, Fernandez A, Gardner K. Abstract 1116: Epigenetic control of the BRCA1 expression by a metabolic switch Cancer Research. 70: 1116-1116. DOI: 10.1158/1538-7445.Am10-1116  0.316
2009 Key J, Scheuermann TH, Anderson PC, Daggett V, Gardner KH. Principles of ligand binding within a completely buried cavity in HIF2α PAS-B Journal of the American Chemical Society. 131: 17647-17654. PMID 19950993 DOI: 10.1021/Ja9073062  0.815
2009 Evans MR, Gardner KH. Slow transition between two β-strand registers is dictated by protein unfolding Journal of the American Chemical Society. 131: 11306-11307. PMID 19722642 DOI: 10.1021/Ja9048338  0.603
2009 De Siervi A, De Luca P, Moiola C, Gueron G, Tongbai R, Chandramouli GVR, Haggerty C, Dzekunova I, Petersen D, Kawasaki E, Whoon JK, Camphausen K, Longo D, Gardner K. Identification of new Rel/NFκB regulatory networks by focused genome location analysis Cell Cycle. 8: 2093-2100. PMID 19502793 DOI: 10.4161/Cc.8.13.8926  0.325
2009 Partch CL, Card PB, Amezcua CA, Gardner KH. Molecular basis of coiled coil coactivator recruitment by the aryl hydrocarbon receptor nuclear translocator (ARNT). The Journal of Biological Chemistry. 284: 15184-92. PMID 19324882 DOI: 10.1074/Jbc.M808479200  0.815
2009 Evans MR, Card PB, Gardner KH. ARNT PAS-B has a fragile native state structure with an alternative β-sheet register nearby in sequence space Proceedings of the National Academy of Sciences of the United States of America. 106: 2617-2622. PMID 19196990 DOI: 10.1073/Pnas.0808270106  0.831
2009 Wu Q, Gardner KH. Structure and insight into blue light-induced changes in the BlrP1 BLUF domain Biochemistry. 48: 2620-2629. PMID 19191473 DOI: 10.1021/Bi802237R  0.543
2009 Scheuermann TH, Tomchick DR, Machius M, Guo Y, Bruick RK, Gardner KH. Artificial ligand binding within the HIF2α PAS-B domain of the HIF2 transcription factor Proceedings of the National Academy of Sciences of the United States of America. 106: 450-455. PMID 19129502 DOI: 10.1073/Pnas.0808092106  0.82
2009 Mukherjee S, Partch CL, Lehotzky RE, Whitham CV, Chu H, Bevins CL, Gardner KH, Hooper LV. Regulation of C-type lectin antimicrobial activity by a flexible N-terminal prosegment. The Journal of Biological Chemistry. 284: 4881-8. PMID 19095652 DOI: 10.1074/Jbc.M808077200  0.692
2009 Evans M, Card P, Gardner K. Human ARNT C-Terminal PAS Domain, 3 Residue IB slip Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2K7S/Pdb  0.799
2008 Nash AI, Ko WH, Harper SM, Gardner KH. A conserved glutamine plays a central role in LOV domain signal transmission and its duration. Biochemistry. 47: 13842-9. PMID 19063612 DOI: 10.1021/Bi801430E  0.828
2008 Wu Q, Ko WH, Gardner KH. Structural requirements for key residues and auxiliary portions of a BLUF domain Biochemistry. 47: 10271-10280. PMID 18771279 DOI: 10.1021/Bi8011687  0.734
2008 Sakiyama H, Wynn RM, Lee WR, Fukasawa M, Mizuguchi H, Gardner KH, Repa JJ, Uyeda K. Regulation of nuclear import/export of carbohydrate response element-binding protein (ChREBP): Interaction of anα-helix of ChREBP with the 14-3-3 proteins and regulation by phosphorylation Journal of Biological Chemistry. 283: 24899-24908. PMID 18606808 DOI: 10.1074/Jbc.M804308200  0.397
2008 Yao X, Rosen MK, Gardner KH. Estimation of the available free energy in a LOV2-Jα photoswitch Nature Chemical Biology. 4: 491-497. PMID 18604202 DOI: 10.1038/Nchembio.99  0.618
2008 Lee J, Tomchick DR, Brautigam CA, Machius M, Kort R, Hellingwerf KJ, Gardner KH. Changes at the KinA PAS-A dimerization interface influence histidine kinase function Biochemistry. 47: 4051-4064. PMID 18324779 DOI: 10.1021/Bi7021156  0.569
2007 Scheuermann TH, Yang J, Zhang L, Gardner KH, Bruick RK. Hypoxia-Inducible Factors Per/ARNT/Sim Domains: Structure and Function Methods in Enzymology. 435: 1,3-24. PMID 17998046 DOI: 10.1016/S0076-6879(07)35001-5  0.809
2007 Ko WH, Nash AI, Gardner KH. A LOVely view of blue light photosensing. Nature Chemical Biology. 3: 372-4. PMID 17576422 DOI: 10.1038/Nchembio0707-372  0.809
2007 Idelman G, Taylor JG, Tongbai R, Chen RA, Haggerty CM, Bilke S, Chanock SJ, Gardner K. Functional profiling of uncommon VCAM1 promoter polymorphisms prevalent in African American populations Human Mutation. 28: 824-829. PMID 17431880 DOI: 10.1002/Humu.20523  0.305
2007 Yao X, Gardner K, Rosen M. Lit‐structure in the dark: conformational dynamics of phototropin LOV2 domain by relaxation NMR The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A270-B  0.589
2006 Kajimura J, Rahman A, Hsu J, Evans MR, Gardner KH, Rick PD. O acetylation of the enterobacterial common antigen polysaccharide is catalyzed by the product of the yiaH gene of Escherichia coli K-12 Journal of Bacteriology. 188: 7542-7550. PMID 16936038 DOI: 10.1128/Jb.00783-06  0.497
2006 Colbert CL, Wu Q, Erbel PJ, Gardner KH, Deisenhofer J. Mechanism of substrate specificity in Bacillus subtilis ResA, a thioredoxin-like protein involved in cytochrome c maturation. Proceedings of the National Academy of Sciences of the United States of America. 103: 4410-5. PMID 16537372 DOI: 10.1073/Pnas.0600552103  0.784
2006 Taylor JG, Idelman G, Tongbai R, Chen RA, Haggerty CM, Chanock SJ, Gardner K. vRare VCAM1 Promoter Haplotypes Prevalent in African Americans Are Hyperinducible. Blood. 108: 1813-1813. DOI: 10.1182/Blood.V108.11.1813.1813  0.332
2005 Card PB, Erbel PJA, Gardner KH. Structural basis of ARNT PAS-B dimerization: Use of a common beta-sheet interface for hetero- and homodimerization Journal of Molecular Biology. 353: 664-677. PMID 16181639 DOI: 10.1016/J.Jmb.2005.08.043  0.812
2005 Socolich M, Lockless SW, Russ WP, Lee H, Gardner KH, Ranganathan R. Evolutionary information for specifying a protein fold. Nature. 437: 512-8. PMID 16177782 DOI: 10.1038/Nature03991  0.359
2005 Gardner KH, Montminy M. Can you hear me now? Regulating transcriptional activators by phosphorylation. Science's Stke : Signal Transduction Knowledge Environment. 2005: pe44. PMID 16160121 DOI: 10.1126/Stke.3012005Pe44  0.364
2005 Yang J, Zhang L, Erbel PJA, Gardner KH, Ding K, Garcia JA, Bruick RK. Functions of the Per/ARNT/Sim domains of the hypoxia-inducible factor Journal of Biological Chemistry. 280: 36047-36054. PMID 16129688 DOI: 10.1074/Jbc.M501755200  0.81
2005 Jung A, Domratcheva T, Tarutina M, Wu Q, Ko WH, Shoeman RL, Gomelsky M, Gardner KH, Schlichting I. Structure of a bacterial BLUF photoreceptor: Insights into blue light-mediated signal transduction Proceedings of the National Academy of Sciences of the United States of America. 102: 12350-12355. PMID 16107542 DOI: 10.1073/Pnas.0500722102  0.742
2005 Card PB, Gardner KH. Identification and optimization of protein domains for NMR studies. Methods in Enzymology. 394: 3-16. PMID 15808215 DOI: 10.1016/S0076-6879(05)94001-9  0.795
2005 Sohn RH, Deming CB, Johns DC, Champion HC, Bian C, Gardner K, Rade JJ. Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B Blood. 105: 3910-3917. PMID 15677570 DOI: 10.1182/Blood-2004-03-0928  0.342
2004 Harper SM, Christie JM, Gardner KH. Disruption of the LOV-Jalpha helix interaction activates phototropin kinase activity. Biochemistry. 43: 16184-92. PMID 15610012 DOI: 10.1021/Bi048092I  0.833
2004 Best JL, Amezcua CA, Mayr B, Flechner L, Murawsky CM, Emerson B, Zor T, Gardner KH, Montminy M. Identification of small-molecule antagonists that inhibit an activator: coactivator interaction. Proceedings of the National Academy of Sciences of the United States of America. 101: 17622-7. PMID 15585582 DOI: 10.1073/Pnas.0406374101  0.811
2004 Galperin MM, Traicoff JL, Ramesh A, Freebern WJ, Haggerty CM, Hartmann DP, Emmert-Buck MR, Gardner K, Knezevic V. Multimembrane dot-blotting: A cost-effective tool for proteome analysis Biotechniques. 36: 1046-1051. PMID 15211757 DOI: 10.2144/04366Pf01  0.32
2004 Harper SM, Neil LC, Day IJ, Hore PJ, Gardner KH. Conformational changes in a photosensory LOV domain monitored by time-resolved NMR spectroscopy. Journal of the American Chemical Society. 126: 3390-1. PMID 15025443 DOI: 10.1021/Ja038224F  0.808
2004 Erbel PJ, Seidel R, Macintosh SE, Gentile LN, Amor JC, Kahn RA, Prestegard JH, McIntosh LP, Gardner KH. Cyclic enterobacterial common antigen: potential contaminant of bacterially expressed protein preparations. Journal of Biomolecular Nmr. 29: 199-204. PMID 15014233 DOI: 10.1023/B:Jnmr.0000019252.65073.24  0.791
2003 Erbel PJ, Card PB, Karakuzu O, Bruick RK, Gardner KH. Structural basis for PAS domain heterodimerization in the basic helix--loop--helix-PAS transcription factor hypoxia-inducible factor. Proceedings of the National Academy of Sciences of the United States of America. 100: 15504-9. PMID 14668441 DOI: 10.1073/Pnas.2533374100  0.833
2003 Harper SM, Neil LC, Gardner KH. Structural basis of a phototropin light switch. Science (New York, N.Y.). 301: 1541-4. PMID 12970567 DOI: 10.1126/Science.1086810  0.816
2003 Smith JL, Collins I, Chandramouli GV, Butscher WG, Zaitseva E, Freebern WJ, Haggerty CM, Doseeva V, Gardner K. Targeting combinatorial transcriptional complex assembly at specific modules within the interleukin-2 promoter by the immunosuppressant SB203580. The Journal of Biological Chemistry. 278: 41034-46. PMID 12896977 DOI: 10.1074/Jbc.M305615200  0.328
2003 Erbel PJ, Barr K, Gao N, Gerwig GJ, Rick PD, Gardner KH. Identification and biosynthesis of cyclic enterobacterial common antigen in Escherichia coli. Journal of Bacteriology. 185: 1995-2004. PMID 12618464 DOI: 10.1128/Jb.185.6.1995-2004.2003  0.761
2002 Amezcua CA, Harper SM, Rutter J, Gardner KH. Structure and interactions of PAS kinase N-terminal PAS domain: model for intramolecular kinase regulation. Structure (London, England : 1993). 10: 1349-61. PMID 12377121 DOI: 10.1016/S0969-2126(02)00857-2  0.827
2002 Xiao T, Gardner KH, Sprang SR. Cosolvent-induced transformation of a death domain tertiary structure. Proceedings of the National Academy of Sciences of the United States of America. 99: 11151-6. PMID 12177432 DOI: 10.1073/Pnas.172188399  0.435
2002 He Q, Cheng P, Yang Y, Wang L, Gardner KH, Liu Y. White collar-1, a DNA binding transcription factor and a light sensor. Science (New York, N.Y.). 297: 840-3. PMID 12098705 DOI: 10.1126/Science.1072795  0.424
2002 Cheng P, Yang Y, Gardner KH, Liu Y. PAS domain-mediated WC-1/WC-2 interaction is essential for maintaining the steady-state level of WC-1 and the function of both proteins in circadian clock and light responses of Neurospora. Molecular and Cellular Biology. 22: 517-24. PMID 11756547 DOI: 10.1128/Mcb.22.2.517-524.2002  0.462
2001 Holdeman TC, Gardner KH. 1H, 13C and 15N chemical shift assignments of the N-terminal PAS domain of mNPAS2. Journal of Biomolecular Nmr. 21: 383-4. PMID 11824759 DOI: 10.1023/A:1013334608913  0.323
2001 Usher KC, Ozkan E, Gardner KH, Deisenhofer J. The plug domain of FepA, a TonB-dependent transport protein from Escherichia coli, binds its siderophore in the absence of the transmembrane barrel domain. Proceedings of the National Academy of Sciences of the United States of America. 98: 10676-81. PMID 11526207 DOI: 10.1073/Pnas.181353398  0.417
2001 Rutter J, Michnoff CH, Harper SM, Gardner KH, McKnight SL. PAS kinase: an evolutionarily conserved PAS domain-regulated serine/threonine kinase. Proceedings of the National Academy of Sciences of the United States of America. 98: 8991-6. PMID 11459942 DOI: 10.1073/Pnas.161284798  0.797
1999 Goto NK, Gardner KH, Mueller GA, Willis RC, Kay LE. A robust and cost-effective method for the production of Val, Leu, Ile (delta 1) methyl-protonated 15N-, 13C-, 2H-labeled proteins. Journal of Biomolecular Nmr. 13: 369-74. PMID 10383198 DOI: 10.1023/A:1008393201236  0.711
1998 Yang D, Gardner KH, Kay LE. A Sensitive Pulse Scheme for Measuring the Backbone Dihedral Angle psi Based on Cross-correlation Between (13)C (alpha)- (1)Halpha Dipolar and Carbonyl Chemical Shift Anisotropy Relaxation Interactions. Journal of Biomolecular Nmr. 11: 213-20. PMID 20700829 DOI: 10.1023/A:1008284315816  0.49
1998 Shan X, Gardner KH, Muhandiram DR, Kay LE, Arrowsmith CH. Subunit-specific backbone NMR assignments of a 64 kDa trp repressor/DNA complex: a role for N-terminal residues in tandem binding. Journal of Biomolecular Nmr. 11: 307-18. PMID 9691278 DOI: 10.1023/A:1008257803130  0.556
1998 Gardner KH, Kay LE. The use of 2H, 13C, 15N multidimensional NMR to study the structure and dynamics of proteins. Annual Review of Biophysics and Biomolecular Structure. 27: 357-406. PMID 9646872 DOI: 10.1146/Annurev.Biophys.27.1.357  0.515
1998 Gardner KH. Solution NMR studies of a 42 KDa Escherichia coli maltose binding protein/β-cyclodextrin complex: Chemical shift assignments and analysis Journal of the American Chemical Society. 120: 11738-11748. DOI: 10.1021/Ja982019W  0.346
1998 Zwahlen C, Gardner KH, Sarma SP, Horita DA, Byrd RA, Kay LE. An NMR experiment for measuring methyl-methyl NOEs in 13C-labeled proteins with high resolution Journal of the American Chemical Society. 120: 7617-7625. DOI: 10.1021/Ja981205Z  0.543
1998 Zwahlen C, Vincent SJF, Gardner KH, Kay LE. Significantly improved resolution for noe correlations from valine and isoleucine (C(y)2) methyl groups in 15N, 13C- and 15N, 13C, 2H-labeled proteins Journal of the American Chemical Society. 120: 4825-4831. DOI: 10.1021/Ja9742601  0.486
1997 Kay LE, Gardner KH. Solution NMR spectroscopy beyond 25 kDa. Current Opinion in Structural Biology. 7: 722-31. PMID 9345633 DOI: 10.1016/S0959-440X(97)80084-X  0.477
1997 Gardner KH, Rosen MK, Kay LE. Global folds of highly deuterated, methyl-protonated proteins by multidimensional NMR. Biochemistry. 36: 1389-401. PMID 9063887 DOI: 10.1021/Bi9624806  0.649
1997 Gardner KH, Kay LE. Production and incorporation of 15N, 13C, 2H (1H-δ1 methyl) isoleucine into proteins for multidimensional NMR studies Journal of the American Chemical Society. 119: 7599-7600. DOI: 10.1021/Ja9706514  0.463
1997 Coleman JE, Rodgers KK, Junker M, Gardner KH, Bellon SF, Steitz TA. Zinc as a structural and folding element of proteins which interact with DNA Journal of Inorganic Biochemistry. 67: 342. DOI: 10.1016/S0162-0134(97)80209-7  0.552
1996 Gardner KH, Konrat R, Rosen MK, Kay LE. An (H)C(CO)NH-TOCSY pulse scheme for sequential assignment of protonated methyl groups in otherwise deuterated (15)N, (13)C-labeled proteins. Journal of Biomolecular Nmr. 8: 351-6. PMID 20686885 DOI: 10.1007/Bf00410333  0.627
1996 Rosen MK, Gardner KH, Willis RC, Parris WE, Pawson T, Kay LE. Selective methyl group protonation of perdeuterated proteins. Journal of Molecular Biology. 263: 627-36. PMID 8947563 DOI: 10.1006/Jmbi.1996.0603  0.664
1996 Shan X, Gardner KH, Muhandiram DR, Rao NS, Arrowsmith CH, Kay LE. Assignment of 15N, 13C(α), 13C(β), and HN resonances in an 15N,13C,2H labeled 64 kDa trp repressor-operator complex using triple-resonance NMR spectroscopy and 2H-decoupling Journal of the American Chemical Society. 118: 6570-6579. DOI: 10.1021/Ja960627A  0.491
1995 Schweitzer BI, Gardner KH, Tucker-Kellogg G. HeteroTOCSY-based experiments for measuring heteronuclear relaxation in nucleic acids and proteins. Journal of Biomolecular Nmr. 6: 180-8. PMID 8589607 DOI: 10.1007/Bf00211782  0.313
1995 Klemba M, Gardner KH, Marino S, Clarke ND, Regan L. Novel metal-binding proteins by design. Nature Structural Biology. 2: 368-73. PMID 7664093 DOI: 10.1038/Nsb0595-368  0.405
1995 Gardner KH, Anderson SF, Coleman JE. Solution structure of the Kluyveromyces lactis LAC9 Cd2 Cys6 DNA-binding domain. Nature Structural Biology. 2: 898-905. PMID 7552715 DOI: 10.1038/Nsb1095-898  0.601
1994 Schweitzer BI, Mikita T, Kellogg GW, Gardner KH, Beardsley GP. Solution structure of a DNA dodecamer containing the anti-neoplastic agent arabinosylcytosine: combined use of NMR, restrained molecular dynamics, and full relaxation matrix refinement. Biochemistry. 33: 11460-75. PMID 7918360 DOI: 10.1021/Bi00204A008  0.304
1994 Gardner KH, Coleman JE. 113Cd-1H heteroTOCSY: a method for determining metal-protein connectivities. Journal of Biomolecular Nmr. 4: 761-74. PMID 7812152 DOI: 10.1007/Bf00398407  0.524
1991 Gardner KH, Pan T, Narula S, Rivera E, Coleman JE. Structure of the binuclear metal-binding site in the GAL4 transcription factor. Biochemistry. 30: 11292-302. PMID 1958667 DOI: 10.1021/Bi00111A015  0.561
1991 Coleman JE, Pan T, Gardner K. Solution structure of the DNA binding domain of the transcription factor GAL4 as determined by 2d NMR methods. Journal of Inorganic Biochemistry. 43: 509. DOI: 10.1016/0162-0134(91)84486-S  0.589
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