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Jerome C. Nwachukwu, Ph.D. - Publications

Affiliations: 
2009 Basic Medical Science New York University, New York, NY, United States 
Area:
Pharmacology, Molecular Biology, Microbiology Biology
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38 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Min CK, Nwachukwu JC, Hou Y, Russo RJ, Papa A, Min J, Peng R, Kim SH, Ziegler Y, Rangarajan ES, Izard T, Katzenellenbogen BS, Katzenellenbogen JA, Nettles KW. Asymmetric allostery in estrogen receptor-α homodimers drives responses to the ensemble of estrogens in the hormonal milieu. Proceedings of the National Academy of Sciences of the United States of America. 121: e2321344121. PMID 38830107 DOI: 10.1073/pnas.2321344121  0.32
2024 Min CK, Nwachukwu JC, Hou Y, Russo RJ, Papa A, Min J, Peng R, Kim SH, Ziegler Y, Rangarajan ES, Izard T, Katzenellenbogen BS, Katzenellenbogen JA, Nettles KW. Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu. Biorxiv : the Preprint Server For Biology. PMID 38645081 DOI: 10.1101/2024.04.10.588871  0.322
2022 Tinivella A, Nwachukwu JC, Angeli A, Foschi F, Benatti AL, Pinzi L, Izard T, Ferraroni M, Erumbi R, Christodoulou MS, Passarella D, Supuran CT, Nettles KW, Rastelli G. Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors. European Journal of Medicinal Chemistry. 246: 115011. PMID 36516582 DOI: 10.1016/j.ejmech.2022.115011  0.343
2021 Min J, Nwachukwu JC, Min CK, Njeri JW, Srinivasan S, Rangarajan ES, Nettles CC, Sanabria Guillen V, Ziegler Y, Yan S, Carlson KE, Hou Y, Kim SH, Novick S, Pascal BD, et al. Dual-mechanism estrogen receptor inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34452998 DOI: 10.1073/pnas.2101657118  0.34
2020 Nwachukwu J, Min J, Srinivasan SK, Rangarajan E, Guillen VS, Ziegler Y, Carlson K, Hou Y, Kim SH, Izard T, Houtman R, Katzenellenbogen BS, Nettles KW, Katzenellenbogen JA. OR12-07 Full Antagonism of Breast Cancer Cell Proliferation Can Result from Many Ligand-Induced Conformational Distortions of the Estrogen Receptor Ligand Binding Domain Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.249  0.445
2020 Katzenellenbogen JA, Min J, Srinivasan S, Rangarajan ES, Nwachukwu JC, Guillen VS, Ziegler Y, Yan S, Carlson KE, Hou Y, Kim SH, Izard T, Houtman R, Nettles KW, Katzenellenbogen BS. Abstract P6-04-10: Combining direct and indirect modes of antiestrogen ligand antagonism of estrogen receptor activity in breast cancer Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-P6-04-10  0.408
2019 Zhang B, Kiefer JR, Blake RA, Chang JH, Hartman S, Ingalla ER, Kleinheinz T, Mody V, Nannini M, Ortwine DF, Ran Y, Sambrone A, Sampath D, Vinogradova M, Zhong Y, ... Nwachukwu JC, et al. Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Bioorganic & Medicinal Chemistry Letters. PMID 30732944 DOI: 10.1016/J.Bmcl.2019.01.036  0.437
2018 Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, Lainé M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, et al. The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. Elife. 7. PMID 30489256 DOI: 10.7554/Elife.37161  0.397
2018 Hudson WH, Vera IMS, Nwachukwu JC, Weikum ER, Herbst AG, Yang Q, Bain DL, Nettles KW, Kojetin DJ, Ortlund EA. Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements. Nature Communications. 9: 1337. PMID 29626214 DOI: 10.1038/S41467-018-03780-1  0.385
2018 Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, Lainé M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, et al. Author response: The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells Elife. DOI: 10.7554/Elife.37161.024  0.338
2017 Weikum ER, de Vera IMS, Nwachukwu JC, Hudson WH, Nettles KW, Kojetin DJ, Ortlund EA. Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes. Nucleic Acids Research. PMID 28591827 DOI: 10.1093/Nar/Gkx509  0.427
2017 Stender JD, Nwachukwu JC, Kastrati I, Kim Y, Strid T, Yakir M, Srinivasan S, Nowak J, Izard T, Rangarajan ES, Carlson KE, Katzenellenbogen JA, Yao XQ, Grant BJ, Leong HS, et al. Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells. Molecular Cell. 65: 1122-1135.e5. PMID 28306507 DOI: 10.1016/J.Molcel.2017.02.008  0.385
2016 Nwachukwu JC, Srinivasan S, Bruno NE, Nowak J, Wright NJ, Minutolo F, Rangarajan ES, Izard T, Yao XQ, Grant BJ, Kojetin DJ, Elemento O, Katzenellenbogen JA, Nettles KW. Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chemical Biology. PMID 28042045 DOI: 10.1016/J.Chembiol.2016.11.014  0.397
2016 Sharma N, Carlson KE, Nwachukwu JC, Srinivasan S, Sharma A, Nettles KW, Katzenellenbogen JA. Exploring the Structural Compliancy versus Specificity of the Estrogen Receptor Using Isomeric Three-Dimensional Ligands. Acs Chemical Biology. PMID 28032978 DOI: 10.1021/Acschembio.6B00918  0.438
2016 Jin Z, Lin H, Srinivasan S, Nwachukwu JC, Bruno N, Griffin PR, Nettles KW, Kamenecka TM. Synthesis of novel steroidal agonists, partial agonists, and antagonists for the glucocorticoid receptor. Bioorganic & Medicinal Chemistry Letters. PMID 27919657 DOI: 10.1016/J.Bmcl.2016.11.007  0.43
2016 Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, et al. Full antagonism of the estrogen receptor without a prototypical ligand side chain. Nature Chemical Biology. PMID 27870835 DOI: 10.1038/Nchembio.2236  0.41
2016 Nwachukwu JC, Srinivasan S, Zheng Y, Wang S, Min J, Dong C, Liao Z, Nowak J, Wright NJ, Houtman R, Carlson KE, Josan JS, Elemento O, Katzenellenbogen JA, Zhou HB, et al. Predictive features of ligand-specific signaling through the estrogen receptor. Molecular Systems Biology. 12: 864. PMID 27107013 DOI: 10.15252/Msb.20156701  0.449
2016 Nwachukwu JC, Srinivasan S, Zheng Y, Wang S, Min J, Dong C, Liao Z, Nowak J, Wright NJ, Houtman R, Carlson KE, Josan JS, Elemento O, Katzenellenbogen JA, Zhou HB, et al. Predictive features of ligand-specific signaling through the estrogen receptor Molecular Systems Biology. 12. DOI: 10.15252/msb.20156701  0.358
2016 Fanning SW, Dharmarajan V, Mayne CG, Toy W, Carlson KE, Martin TA, Nowak J, Nwachukwu J, Hosfield DJ, Tajkhorshid E, Chandarlapaty S, Griffin P, Shen Y, Katzenellenbogen JA, Greene GL. Abstract 4854: Bazedoxifene inhibits ESR1 somatic mutants with improved potency compared to tamoxifene and raloxifene Cancer Research. 76: 4854-4854. DOI: 10.1158/1538-7445.Am2016-4854  0.405
2015 Kojetin DJ, Matta-Camacho E, Hughes TS, Srinivasan S, Nwachukwu JC, Cavett V, Nowak J, Chalmers MJ, Marciano DP, Kamenecka TM, Shulman AI, Rance M, Griffin PR, Bruning JB, Nettles KW. Structural mechanism for signal transduction in RXR nuclear receptor heterodimers. Nature Communications. 6: 8013. PMID 26289479 DOI: 10.1038/Ncomms9013  0.39
2015 Zhao Y, Gong P, Chen Y, Nwachukwu JC, Srinivasan S, Ko C, Bagchi MK, Taylor RN, Korach KS, Nettles KW, Katzenellenbogen JA, Katzenellenbogen BS. Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis. Science Translational Medicine. 7: 271ra9. PMID 25609169 DOI: 10.1126/Scitranslmed.3010626  0.336
2014 Nwachukwu JC, Srinivasan S, Bruno NE, Parent AA, Hughes TS, Pollock JA, Gjyshi O, Cavett V, Nowak J, Garcia-Ordonez RD, Houtman R, Griffin PR, Kojetin DJ, Katzenellenbogen JA, Conkright MD, et al. Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. Elife. 3: e02057. PMID 24771768 DOI: 10.7554/Elife.02057  0.349
2014 Liao ZQ, Dong C, Carlson KE, Srinivasan S, Nwachukwu JC, Chesnut RW, Sharma A, Nettles KW, Katzenellenbogen JA, Zhou HB. Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor. Journal of Medicinal Chemistry. 57: 3532-45. PMID 24708493 DOI: 10.1021/Jm500268J  0.368
2014 Nwachukwu JC, Srinivasan S, Bruno NE, Parent AA, Hughes TS, Pollock JA, Gjyshi O, Cavett V, Nowak J, Garcia-Ordonez RD, Houtman R, Griffin PR, Kojetin DJ, Katzenellenbogen JA, Conkright MD, et al. Author response: Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network Elife. DOI: 10.7554/Elife.02057.040  0.352
2013 Min J, Wang P, Srinivasan S, Nwachukwu JC, Guo P, Huang M, Carlson KE, Katzenellenbogen JA, Nettles KW, Zhou HB. Thiophene-core estrogen receptor ligands having superagonist activity. Journal of Medicinal Chemistry. 56: 3346-66. PMID 23586645 DOI: 10.1021/Jm400157E  0.423
2013 Srinivasan S, Nwachukwu JC, Parent AA, Cavett V, Nowak J, Hughes TS, Kojetin DJ, Katzenellenbogen JA, Nettles KW. Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α. Nature Chemical Biology. 9: 326-32. PMID 23524984 DOI: 10.1038/Nchembio.1214  0.407
2012 Zhu M, Zhang C, Nwachukwu JC, Srinivasan S, Cavett V, Zheng Y, Carlson KE, Dong C, Katzenellenbogen JA, Nettles KW, Zhou HB. Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides. Organic & Biomolecular Chemistry. 10: 8692-700. PMID 23033157 DOI: 10.1039/C2Ob26531A  0.434
2012 Zheng Y, Zhu M, Srinivasan S, Nwachukwu JC, Cavett V, Min J, Carlson KE, Wang P, Dong C, Katzenellenbogen JA, Nettles KW, Zhou HB. Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands. Chemmedchem. 7: 1094-100. PMID 22517684 DOI: 10.1002/Cmdc.201200048  0.439
2012 Wang P, Min J, Nwachukwu JC, Cavett V, Carlson KE, Guo P, Zhu M, Zheng Y, Dong C, Katzenellenbogen JA, Nettles KW, Zhou HB. Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide. Journal of Medicinal Chemistry. 55: 2324-41. PMID 22283328 DOI: 10.1021/Jm201556R  0.399
2012 Nwachukwu JC, Nettles KW. The nuclear receptor signalling scaffold: insights from full-length structures. The Embo Journal. 31: 251-3. PMID 22252143 DOI: 10.1038/Emboj.2011.475  0.395
2011 Mita P, Savas JN, Djouder N, Yates JR, Ha S, Ruoff R, Schafler ED, Nwachukwu JC, Tanese N, Cowan NJ, Zavadil J, Garabedian MJ, Logan SK. Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP. Molecular and Cellular Biology. 31: 3639-52. PMID 21730289 DOI: 10.1128/Mcb.05429-11  0.628
2009 Nwachukwu JC, Mita P, Ruoff R, Ha S, Wang Q, Huang SJ, Taneja SS, Brown M, Gerald WL, Garabedian MJ, Logan SK. Genome-wide impact of androgen receptor trapped clone-27 loss on androgen-regulated transcription in prostate cancer cells. Cancer Research. 69: 3140-7. PMID 19318562 DOI: 10.1158/0008-5472.CAN-08-3738  0.593
2008 Logan SK, Nwachukwu JC, Mita P, Taneja SS, Garabedian MJ. REGULATION OF PROSTATE CELL GROWTH THROUGH ANDROGEN RECEPTOR COFACTORS Journal of Urology. 179: 190-190. DOI: 10.1016/S0022-5347(08)60552-2  0.567
2007 Nwachukwu JC, Li W, Pineda-Torra I, Huang HY, Ruoff R, Shapiro E, Taneja SS, Logan SK, Garabedian MJ. Transcriptional regulation of the androgen receptor cofactor androgen receptor trapped clone-27. Molecular Endocrinology (Baltimore, Md.). 21: 2864-76. PMID 17761951 DOI: 10.1210/Me.2007-0094  0.614
2007 Das S, Nwachukwu JC, Li D, Vulin AI, Martinez-Caballero S, Kinnally KW, Samuels HH. The nuclear receptor interacting factor-3 transcriptional coregulator mediates rapid apoptosis in breast cancer cells through direct and bystander-mediated events. Cancer Research. 67: 1775-82. PMID 17308120 DOI: 10.1158/0008-5472.Can-06-4034  0.351
2007 Das S, Nwachukwu JC, Li D, Vulin AJ, Martinez-Caballero S, Kinnally KW, Samuels HH. Erratum: The nuclear receptor interacting factor-3 transcriptional coregulator mediates rapid apoptosis in breast cancer cells through direct and bystander-mediated events (Cancer Research (2007) 67, (1775-1782)) Cancer Research. 67. DOI: 10.1158/0008-5472.Can-67-9-Cor  0.381
2006 Koklanaris N, Nwachukwu JC, Huang SJ, Guller S, Karpisheva K, Garabedian M, Lee MJ. First-trimester trophoblast cell model gene response to hypoxia. American Journal of Obstetrics and Gynecology. 194: 687-93. PMID 16522398 DOI: 10.1016/J.Ajog.2006.01.067  0.531
2005 Koklanaris (F) N, Nwachukwu J, Huang SJ, Guller S, Garabedian M, Lee M. Placental gene response to early hypoxia American Journal of Obstetrics and Gynecology. 193: S25. DOI: 10.1016/J.Ajog.2005.10.067  0.526
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