| Year |
Citation |
Score |
| 2021 |
Yoon S, Munoz A, Yamrom B, Lee YH, Andrews P, Marks S, Wang Z, Reeves C, Winterkorn L, Krieger AM, Buja A, Pradhan K, Ronemus M, Baldwin KK, Levy D, ... Wigler M, et al. Rates of contributory de novo mutation in high and low-risk autism families. Communications Biology. 4: 1026. PMID 34471188 DOI: 10.1038/s42003-021-02533-z |
0.699 |
|
| 2020 |
Miyabayashi K, Baker LA, Deschenes A, Traub B, Caligiuri G, Plenker D, Alagesan B, Belleau P, Li S, Kendall J, Jang GH, Kawaguchi RK, Somerville TDD, Tiriac H, Hwang CI, ... ... Wigler M, et al. Intraductal transplantation models of human pancreatic ductal adenocarcinoma reveal progressive transition of molecular subtypes. Cancer Discovery. PMID 32703770 DOI: 10.1158/2159-8290.Cd-20-0133 |
0.333 |
|
| 2020 |
Baslan T, Kendall J, Volyanskyy K, McNamara K, Cox H, D'Italia S, Ambrosio F, Riggs M, Rodgers L, Leotta A, Song J, Mao Y, Wu J, Shah R, Gularte-Mérida R, ... ... Wigler M, et al. Novel insights into breast cancer copy number genetic heterogeneity revealed by single-cell genome sequencing. Elife. 9. PMID 32401198 DOI: 10.7554/Elife.51480 |
0.32 |
|
| 2020 |
Vasudevan A, Baruah PS, Smith JC, Wang Z, Sayles NM, Andrews P, Kendall J, Leu J, Chunduri NK, Levy D, Wigler M, Storchová Z, Sheltzer JM. Single-Chromosomal Gains Can Function as Metastasis Suppressors and Promoters in Colon Cancer. Developmental Cell. 52: 413-428.e6. PMID 32097652 DOI: 10.1016/J.Devcel.2020.01.034 |
0.325 |
|
| 2019 |
Li S, Kendall J, Park S, Wang Z, Alexander J, Moffitt A, Ranade N, Danyko C, Gegenhuber B, Fischer S, Robinson BD, Lepor H, Tollkuhn J, Gillis J, Brouzes E, ... ... Wigler M, et al. Copolymerization of single cell nucleic acids into balls of acrylamide gel. Genome Research. PMID 31727682 DOI: 10.1101/Gr.253047.119 |
0.315 |
|
| 2017 |
Kumar V, Rosenbaum J, Wang Z, Forcier T, Ronemus M, Wigler M, Levy D. Partial bisulfite conversion for unique template sequencing. Nucleic Acids Research. PMID 29161423 DOI: 10.1093/Nar/Gkx1054 |
0.303 |
|
| 2017 |
Krasnitz A, Kendall J, Alexander J, Levy D, Wigler M. Early Detection of Cancer in Blood Using Single-Cell Analysis: A Proposal. Trends in Molecular Medicine. PMID 28587830 DOI: 10.1016/J.Molmed.2017.05.005 |
0.314 |
|
| 2016 |
Fang H, Bergmann EA, Arora K, Vacic V, Zody MC, Iossifov I, O'Rawe JA, Wu Y, Jimenez Barron LT, Rosenbaum J, Ronemus M, Lee YH, Wang Z, Dikoglu E, Jobanputra V, ... ... Wigler M, et al. Indel variant analysis of short-read sequencing data with Scalpel. Nature Protocols. 11: 2529-2548. PMID 27854363 DOI: 10.1038/Nprot.2016.150 |
0.327 |
|
| 2015 |
Iossifov I, Levy D, Allen J, Ye K, Ronemus M, Lee YH, Yamrom B, Wigler M. Low load for disruptive mutations in autism genes and their biased transmission. Proceedings of the National Academy of Sciences of the United States of America. PMID 26401017 DOI: 10.1073/Pnas.1516376112 |
0.36 |
|
| 2015 |
Baslan T, Kendall J, Ward B, Cox H, Leotta A, Rodgers L, Riggs M, D'Italia S, Sun G, Yong M, Miskimen K, Gilmore H, Saborowski M, Dimitrova N, Krasnitz A, ... ... Wigler M, et al. Optimizing sparse sequencing of single cells for highly multiplex copy number profiling. Genome Research. 25: 714-24. PMID 25858951 DOI: 10.1101/Gr.188060.114 |
0.325 |
|
| 2015 |
Jayaprakash AD, Benson EK, Gone S, Liang R, Shim J, Lambertini L, Toloue MM, Wigler M, Aaronson SA, Sachidanandam R. Stable heteroplasmy at the single-cell level is facilitated by intercellular exchange of mtDNA. Nucleic Acids Research. 43: 2177-87. PMID 25653158 DOI: 10.1093/Nar/Gkv052 |
0.323 |
|
| 2015 |
Rye IH, Lundin P, Månér S, Fjelldal R, Naume B, Wigler M, Hicks J, Børresen-Dale AL, Zetterberg A, Russnes HG. Quantitative multigene FISH on breast carcinomas identifies der(1;16)(q10;p10) as an early event in luminal A tumors. Genes, Chromosomes & Cancer. 54: 235-48. PMID 25546585 DOI: 10.1002/Gcc.22237 |
0.319 |
|
| 2014 |
Iossifov I, O'Roak BJ, Sanders SJ, Ronemus M, Krumm N, Levy D, Stessman HA, Witherspoon KT, Vives L, Patterson KE, Smith JD, Paeper B, Nickerson DA, Dea J, Dong S, ... ... Wigler M, et al. The contribution of de novo coding mutations to autism spectrum disorder. Nature. 515: 216-21. PMID 25363768 DOI: 10.1038/Nature13908 |
0.322 |
|
| 2014 |
Levy D, Wigler M. Facilitated sequence counting and assembly by template mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 111: E4632-7. PMID 25313059 DOI: 10.1073/Pnas.1416204111 |
0.307 |
|
| 2014 |
Dago AE, Stepansky A, Carlsson A, Luttgen M, Kendall J, Baslan T, Kolatkar A, Wigler M, Bethel K, Gross ME, Hicks J, Kuhn P. Rapid phenotypic and genomic change in response to therapeutic pressure in prostate cancer inferred by high content analysis of single circulating tumor cells. Plos One. 9: e101777. PMID 25084170 DOI: 10.1371/Journal.Pone.0101777 |
0.354 |
|
| 2013 |
Welsh A, Danila DC, Anand A, Kendall J, Sawyers CL, Fleisher M, Wigler M, Hicks JB, Scher HI. Genomic heterogeneity of circulating tumor cells in castration-resistant prostate cancer (CRPC) revealed by single-cell sequencing. Journal of Clinical Oncology. 31: 5030-5030. DOI: 10.1200/Jco.2013.31.15_Suppl.5030 |
0.326 |
|
| 2012 |
Wigler M. Broad applications of single-cell nucleic acid analysis in biomedical research. Genome Medicine. 4: 79. PMID 23114035 DOI: 10.1186/Gm380 |
0.301 |
|
| 2012 |
Xue W, Kitzing T, Roessler S, Zuber J, Krasnitz A, Schultz N, Revill K, Weissmueller S, Rappaport AR, Simon J, Zhang J, Luo W, Hicks J, Zender L, Wang XW, ... ... Wigler M, et al. A cluster of cooperating tumor-suppressor gene candidates in chromosomal deletions. Proceedings of the National Academy of Sciences of the United States of America. 109: 8212-7. PMID 22566646 DOI: 10.1073/Pnas.1206062109 |
0.404 |
|
| 2012 |
Baslan T, Kendall J, Rodgers L, Cox H, Riggs M, Stepansky A, Troge J, Ravi K, Esposito D, Lakshmi B, Wigler M, Navin N, Hicks J. Genome-wide copy number analysis of single cells. Nature Protocols. 7: 1024-41. PMID 22555242 DOI: 10.1038/Nprot.2012.039 |
0.301 |
|
| 2012 |
Iossifov I, Ronemus M, Levy D, Wang Z, Hakker I, Rosenbaum J, Yamrom B, Lee YH, Narzisi G, Leotta A, Kendall J, Grabowska E, Ma B, Marks S, Rodgers L, ... ... Wigler M, et al. De novo gene disruptions in children on the autistic spectrum. Neuron. 74: 285-99. PMID 22542183 DOI: 10.1016/J.Neuron.2012.04.009 |
0.365 |
|
| 2011 |
Navin N, Kendall J, Troge J, Andrews P, Rodgers L, McIndoo J, Cook K, Stepansky A, Levy D, Esposito D, Muthuswamy L, Krasnitz A, McCombie WR, Hicks J, Wigler M. Tumour evolution inferred by single-cell sequencing. Nature. 472: 90-4. PMID 21399628 DOI: 10.1038/Nature09807 |
0.308 |
|
| 2011 |
Kamalakaran S, Varadan V, Giercksky Russnes HE, Levy D, Kendall J, Janevski A, Riggs M, Banerjee N, Synnestvedt M, Schlichting E, KÃ¥resen R, Shama Prasada K, Rotti H, Rao R, Rao L, ... ... Wigler M, et al. DNA methylation patterns in luminal breast cancers differ from non-luminal subtypes and can identify relapse risk independent of other clinical variables. Molecular Oncology. 5: 77-92. PMID 21169070 DOI: 10.1016/J.Molonc.2010.11.002 |
0.342 |
|
| 2010 |
Navin N, Krasnitz A, Rodgers L, Cook K, Meth J, Kendall J, Riggs M, Eberling Y, Troge J, Grubor V, Levy D, Lundin P, Månér S, Zetterberg A, Hicks J, ... Wigler M, et al. Inferring tumor progression from genomic heterogeneity. Genome Research. 20: 68-80. PMID 19903760 DOI: 10.1101/Gr.099622.109 |
0.338 |
|
| 2009 |
Bric A, Miething C, Bialucha CU, Scuoppo C, Zender L, Krasnitz A, Xuan Z, Zuber J, Wigler M, Hicks J, McCombie RW, Hemann MT, Hannon GJ, Powers S, Lowe SW. Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model. Cancer Cell. 16: 324-35. PMID 19800577 DOI: 10.1016/J.Ccr.2009.08.015 |
0.359 |
|
| 2009 |
Varadan V, Kamalakaran S, Russnes HG, Levy D, Kendall J, Janevski A, Riggs M, Banerjee N, Synnestvedt M, Schlichting E, Kåresen R, Lucito R, Wigler M, Dimitrova N, Naume B, et al. Genome-Wide DNA Methylation Profiles of Breast Tumors Reveal Loci Associated with Relapse Risk. Cancer Research. 69: 4046-4046. DOI: 10.1158/0008-5472.Sabcs-09-4046 |
0.313 |
|
| 2009 |
Kamalakaran S, Russnes HG, Janevski A, Levy D, Kendall J, Varadan V, Riggs M, Banerjee N, Synnestvedt M, Schlichting E, Kåresen R, Lucito R, Wigler M, Dimitrova N, Naume B, et al. Subtype Dependent Alterations of the DNA Methylation Landscape in Breast Cancer. Cancer Research. 69: 1144-1144. DOI: 10.1158/0008-5472.Sabcs-09-1144 |
0.331 |
|
| 2008 |
Zender L, Xue W, Zuber J, Semighini CP, Krasnitz A, Ma B, Zender P, Kubicka S, Luk JM, Schirmacher P, McCombie WR, Wigler M, Hicks J, Hannon GJ, Powers S, et al. An oncogenomics-based in vivo RNAi screen identifies tumor suppressors in liver cancer. Cell. 135: 852-64. PMID 19012953 DOI: 10.1016/J.Cell.2008.09.061 |
0.385 |
|
| 2008 |
Xue W, Krasnitz A, Lucito R, Sordella R, Vanaelst L, Cordon-Cardo C, Singer S, Kuehnel F, Wigler M, Powers S, Zender L, Lowe SW. DLC1 is a chromosome 8p tumor suppressor whose loss promotes hepatocellular carcinoma. Genes & Development. 22: 1439-44. PMID 18519636 DOI: 10.1101/Gad.1672608 |
0.406 |
|
| 2007 |
Egan CM, Sridhar S, Wigler M, Hall IM. Recurrent DNA copy number variation in the laboratory mouse. Nature Genetics. 39: 1384-9. PMID 17965714 DOI: 10.1038/Ng.2007.19 |
0.308 |
|
| 2007 |
Lucito R, Suresh S, Walter K, Pandey A, Lakshmi B, Krasnitz A, Sebat J, Wigler M, Klein AP, Brune K, Palmisano E, Maitra A, Goggins M, Hruban RH. Copy-number variants in patients with a strong family history of pancreatic cancer. Cancer Biology & Therapy. 6: 1592-9. PMID 17912030 DOI: 10.4161/Cbt.6.10.4725 |
0.341 |
|
| 2007 |
Sebat J, Lakshmi B, Malhotra D, Troge J, Lese-Martin C, Walsh T, Yamrom B, Yoon S, Krasnitz A, Kendall J, Leotta A, Pai D, Zhang R, Lee YH, Hicks J, ... ... Wigler M, et al. Strong association of de novo copy number mutations with autism. Science (New York, N.Y.). 316: 445-9. PMID 17363630 DOI: 10.1126/Science.1138659 |
0.309 |
|
| 2006 |
Pelham RJ, Rodgers L, Hall I, Lucito R, Nguyen KC, Navin N, Hicks J, Mu D, Powers S, Wigler M, Botstein D. Identification of alterations in DNA copy number in host stromal cells during tumor progression. Proceedings of the National Academy of Sciences of the United States of America. 103: 19848-53. PMID 17167050 DOI: 10.1073/Pnas.0609635104 |
0.355 |
|
| 2006 |
Lakshmi B, Hall IM, Egan C, Alexander J, Leotta A, Healy J, Zender L, Spector MS, Xue W, Lowe SW, Wigler M, Lucito R. Mouse genomic representational oligonucleotide microarray analysis: detection of copy number variations in normal and tumor specimens. Proceedings of the National Academy of Sciences of the United States of America. 103: 11234-9. PMID 16844783 DOI: 10.1073/Pnas.0602984103 |
0.318 |
|
| 2006 |
Zender L, Spector MS, Xue W, Flemming P, Cordon-Cardo C, Silke J, Fan ST, Luk JM, Wigler M, Hannon GJ, Mu D, Lucito R, Powers S, Lowe SW. Identification and validation of oncogenes in liver cancer using an integrative oncogenomic approach. Cell. 125: 1253-67. PMID 16814713 DOI: 10.1016/J.Cell.2006.05.030 |
0.368 |
|
| 2006 |
Navin N, Grubor V, Hicks J, Leibu E, Thomas E, Troge J, Riggs M, Lundin P, Månér S, Sebat J, Zetterberg A, Wigler M. PROBER: oligonucleotide FISH probe design software. Bioinformatics (Oxford, England). 22: 2437-8. PMID 16740623 DOI: 10.1093/Bioinformatics/Btl273 |
0.307 |
|
| 2004 |
Sebat J, Lakshmi B, Troge J, Alexander J, Young J, Lundin P, Månér S, Massa H, Walker M, Chi M, Navin N, Lucito R, Healy J, Hicks J, Ye K, ... ... Wigler M, et al. Large-scale copy number polymorphism in the human genome. Science (New York, N.Y.). 305: 525-8. PMID 15273396 DOI: 10.1126/Science.1098918 |
0.35 |
|
| 2004 |
Thomas EE, Srebro N, Sebat J, Navin N, Healy J, Mishra B, Wigler M. Distribution of short paired duplications in mammalian genomes. Proceedings of the National Academy of Sciences of the United States of America. 101: 10349-54. PMID 15240876 DOI: 10.1073/Pnas.0403727101 |
0.308 |
|
| 2003 |
Lucito R, Healy J, Alexander J, Reiner A, Esposito D, Chi M, Rodgers L, Brady A, Sebat J, Troge J, West JA, Rostan S, Nguyen KC, Powers S, Ye KQ, ... ... Wigler M, et al. Representational oligonucleotide microarray analysis: a high-resolution method to detect genome copy number variation. Genome Research. 13: 2291-305. PMID 12975311 DOI: 10.1101/Gr.1349003 |
0.312 |
|
| 2001 |
Scheffzek K, Grünewald P, Wohlgemuth S, Kabsch W, Tu H, Wigler M, Wittinghofer A, Herrmann C. The Ras-Byr2RBD complex: structural basis for Ras effector recognition in yeast. Structure (London, England : 1993). 9: 1043-50. PMID 11709168 DOI: 10.1016/S0969-2126(01)00674-8 |
0.37 |
|
| 2001 |
Stolarov J, Chang K, Reiner A, Rodgers L, Hannon GJ, Wigler MH, Mittal V. Design of a retroviral-mediated ecdysone-inducible system and its application to the expression profiling of the PTEN tumor suppressor. Proceedings of the National Academy of Sciences of the United States of America. 98: 13043-8. PMID 11687610 DOI: 10.1073/Pnas.221450598 |
0.775 |
|
| 2001 |
Wen S, Stolarov J, Myers MP, Su JD, Wigler MH, Tonks NK, Durden DL. PTEN controls tumor-induced angiogenesis. Proceedings of the National Academy of Sciences of the United States of America. 98: 4622-7. PMID 11274365 DOI: 10.1073/Pnas.081063798 |
0.755 |
|
| 2001 |
Lucito R, Alexander J, Rostan S, West J, Wigler M. Detection of gene copy number fluctuations with microarrays using genomic representations Nature Genetics. 27: 70-70. DOI: 10.1038/87190 |
0.316 |
|
| 2000 |
Lucito R, West J, Reiner A, Alexander J, Esposito D, Mishra B, Powers S, Norton L, Wigler M. Detecting gene copy number fluctuations in tumor cells by microarray analysis of genomic representations. Genome Research. 10: 1726-36. PMID 11076858 DOI: 10.1101/Gr.138300 |
0.35 |
|
| 1999 |
Tu H, Wigler M. Genetic evidence for Pak1 autoinhibition and its release by Cdc42. Molecular and Cellular Biology. 19: 602-11. PMID 9858584 DOI: 10.1128/Mcb.19.1.602 |
0.332 |
|
| 1999 |
Lucito R, West J, Reiner A, Alexander J, Yen C, Nakamura M, Wigler M. Application of representational microarrays to genetic analysis of primary tumours Nature Genetics. 23: 60-60. DOI: 10.1038/14359 |
0.328 |
|
| 1998 |
Myers MP, Pass I, Batty IH, Van der Kaay J, Stolarov JP, Hemmings BA, Wigler MH, Downes CP, Tonks NK. The lipid phosphatase activity of PTEN is critical for its tumor supressor function. Proceedings of the National Academy of Sciences of the United States of America. 95: 13513-8. PMID 9811831 DOI: 10.1073/Pnas.95.23.13513 |
0.776 |
|
| 1998 |
Webb CP, Van Aelst L, Wigler MH, Vande Woude GF. Signaling pathways in Ras-mediated tumorigenicity and metastasis. Proceedings of the National Academy of Sciences of the United States of America. 95: 8773-8. PMID 9671754 DOI: 10.1073/pnas.95.15.8773 |
0.635 |
|
| 1998 |
Lucito R, Nakimura M, West JA, Han Y, Chin K, Jensen K, McCombie R, Gray JW, Wigler M. Genetic analysis using genomic representations. Proceedings of the National Academy of Sciences of the United States of America. 95: 4487-92. PMID 9539764 DOI: 10.1073/Pnas.95.8.4487 |
0.358 |
|
| 1997 |
Tu H, Barr M, Dong DL, Wigler M. Multiple regulatory domains on the Byr2 protein kinase. Molecular and Cellular Biology. 17: 5876-87. PMID 9315645 DOI: 10.1128/Mcb.17.10.5876 |
0.325 |
|
| 1997 |
Myers MP, Stolarov JP, Eng C, Li J, Wang SI, Wigler MH, Parsons R, Tonks NK. P-TEN, the tumor suppressor from human chromosome 10q23, is a dual-specificity phosphatase. Proceedings of the National Academy of Sciences of the United States of America. 94: 9052-7. PMID 9256433 DOI: 10.1073/Pnas.94.17.9052 |
0.765 |
|
| 1996 |
Barr MM, Tu H, Van Aelst L, Wigler M. Identification of Ste4 as a potential regulator of Byr2 in the sexual response pathway of Schizosaccharomyces pombe. Molecular and Cellular Biology. 16: 5597-603. PMID 8816472 DOI: 10.1128/Mcb.16.10.5597 |
0.562 |
|
| 1996 |
Khosravi-Far R, White MA, Westwick JK, Solski PA, Chrzanowska-Wodnicka M, Van Aelst L, Wigler MH, Der CJ. Oncogenic Ras activation of Raf/mitogen-activated protein kinase-independent pathways is sufficient to cause tumorigenic transformation. Molecular and Cellular Biology. 16: 3923-33. PMID 8668210 DOI: 10.1128/Mcb.16.7.3923 |
0.614 |
|
| 1995 |
Lisitsyn N, Wigler M. Representational difference analysis in detection of genetic lesions in cancer. Methods in Enzymology. 254: 291-304. PMID 8531693 DOI: 10.1016/0076-6879(95)54021-0 |
0.316 |
|
| 1995 |
White MA, Nicolette C, Minden A, Polverino A, Van Aelst L, Karin M, Wigler MH. Multiple Ras functions can contribute to mammalian cell transformation. Cell. 80: 533-41. PMID 7867061 DOI: 10.1016/0092-8674(95)90507-3 |
0.609 |
|
| 1994 |
Xu HP, White M, Marcus S, Wigler M. Concerted action of RAS and G proteins in the sexual response pathways of Schizosaccharomyces pombe. Molecular and Cellular Biology. 14: 50-8. PMID 8264618 DOI: 10.1128/Mcb.14.1.50 |
0.399 |
|
| 1994 |
Jung V, Wei W, Ballester R, Camonis J, Mi S, Van Aelst L, Wigler M, Broek D. Two types of RAS mutants that dominantly interfere with activators of RAS. Molecular and Cellular Biology. 14: 3707-18. PMID 8196614 DOI: 10.1128/Mcb.14.6.3707 |
0.624 |
|
| 1994 |
Van Aelst L, White MA, Wigler MH. Ras partners. Cold Spring Harbor Symposia On Quantitative Biology. 59: 181-6. PMID 7587068 |
0.563 |
|
| 1993 |
Chardin P, Camonis JH, Gale NW, van Aelst L, Schlessinger J, Wigler MH, Bar-Sagi D. Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2. Science (New York, N.Y.). 260: 1338-43. PMID 8493579 DOI: 10.1126/Science.8493579 |
0.635 |
|
| 1993 |
Neiman AM, Stevenson BJ, Xu HP, Sprague GF, Herskowitz I, Wigler M, Marcus S. Functional homology of protein kinases required for sexual differentiation in Schizosaccharomyces pombe and Saccharomyces cerevisiae suggests a conserved signal transduction module in eukaryotic organisms. Molecular Biology of the Cell. 4: 107-20. PMID 8443406 DOI: 10.1091/Mbc.4.1.107 |
0.356 |
|
| 1993 |
Gutmann DH, Boguski M, Marchuk D, Wigler M, Collins FS, Ballester R. Analysis of the neurofibromatosis type 1 (NF1) GAP-related domain by site-directed mutagenesis. Oncogene. 8: 761-9. PMID 8437860 |
0.309 |
|
| 1993 |
Van Aelst L, Barr M, Marcus S, Polverino A, Wigler M. Complex formation between RAS and RAF and other protein kinases. Proceedings of the National Academy of Sciences of the United States of America. 90: 6213-7. PMID 8327501 DOI: 10.1073/Pnas.90.13.6213 |
0.608 |
|
| 1992 |
Kawamukai M, Gerst J, Field J, Riggs M, Rodgers L, Wigler M, Young D. Genetic and biochemical analysis of the adenylyl cyclase-associated protein, cap, in Schizosaccharomyces pombe. Molecular Biology of the Cell. 3: 167-80. PMID 1550959 DOI: 10.1091/Mbc.3.2.167 |
0.697 |
|
| 1992 |
Wigler M, Sweet R, Sim GK, Wold B, Pellicer A, Lacy E, Maniatis T, Silverstein S, Axel R. Transformation of mammalian cells with genes from prokaryotes and eukaryotes. 1979. Biotechnology (Reading, Mass.). 24: 444-52. PMID 1422052 |
0.699 |
|
| 1992 |
Shibuya EK, Polverino AJ, Chang E, Wigler M, Ruderman JV. Oncogenic ras triggers the activation of 42-kDa mitogen-activated protein kinase in extracts of quiescent Xenopus oocytes. Proceedings of the National Academy of Sciences of the United States of America. 89: 9831-5. PMID 1384061 DOI: 10.1073/Pnas.89.20.9831 |
0.375 |
|
| 1992 |
Gerst JE, Rodgers L, Riggs M, Wigler M. SNC1, a yeast homolog of the synaptic vesicle-associated membrane protein/synaptobrevin gene family: genetic interactions with the RAS and CAP genes. Proceedings of the National Academy of Sciences of the United States of America. 89: 4338-42. PMID 1316605 DOI: 10.1073/Pnas.89.10.4338 |
0.41 |
|
| 1991 |
Wang Y, Xu HP, Riggs M, Rodgers L, Wigler M. byr2, a Schizosaccharomyces pombe gene encoding a protein kinase capable of partial suppression of the ras1 mutant phenotype. Molecular and Cellular Biology. 11: 3554-63. PMID 2046669 DOI: 10.1128/Mcb.11.7.3554 |
0.421 |
|
| 1991 |
Gerst JE, Ferguson K, Vojtek A, Wigler M, Field J. CAP is a bifunctional component of the Saccharomyces cerevisiae adenylyl cyclase complex. Molecular and Cellular Biology. 11: 1248-57. PMID 1996090 DOI: 10.1128/Mcb.11.3.1248 |
0.374 |
|
| 1991 |
Wang Y, Boguski M, Riggs M, Rodgers L, Wigler M. sar1, a gene from Schizosaccharomyces pombe encoding a protein that regulates ras1. Cell Regulation. 2: 453-65. PMID 1883874 DOI: 10.1091/Mbc.2.6.453 |
0.351 |
|
| 1991 |
Vojtek A, Haarer B, Field J, Gerst J, Pollard TD, Brown S, Wigler M. Evidence for a functional link between profilin and CAP in the yeast S. cerevisiae. Cell. 66: 497-505. PMID 1868547 DOI: 10.1016/0092-8674(81)90013-1 |
0.353 |
|
| 1991 |
Young D, O'Neill K, Broek D, Wigler M. The adenylyl cyclase-encoding gene from Saccharomyces kluyveri. Gene. 102: 129-32. PMID 1864503 DOI: 10.1016/0378-1119(91)90551-L |
0.733 |
|
| 1991 |
Kawamukai M, Ferguson K, Wigler M, Young D. Genetic and biochemical analysis of the adenylyl cyclase of Schizosaccharomyces pombe. Cell Regulation. 2: 155-64. PMID 1863602 DOI: 10.1091/MBC.2.2.155 |
0.692 |
|
| 1991 |
Colicelli J, Nicolette C, Birchmeier C, Rodgers L, Riggs M, Wigler M. Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 88: 2913-7. PMID 1849280 DOI: 10.1073/Pnas.88.7.2913 |
0.382 |
|
| 1991 |
Daar I, Nebreda AR, Yew N, Sass P, Paules R, Santos E, Wigler M, Vande Woude GF. The ras oncoprotein and M-phase activity. Science (New York, N.Y.). 253: 74-6. PMID 1829549 DOI: 10.1126/Science.1829549 |
0.332 |
|
| 1990 |
Field J, Xu HP, Michaeli T, Ballester R, Sass P, Wigler M, Colicelli J. Mutations of the adenylyl cyclase gene that block RAS function in Saccharomyces cerevisiae. Science (New York, N.Y.). 247: 464-7. PMID 2405488 DOI: 10.1126/Science.2405488 |
0.409 |
|
| 1990 |
Birchmeier C, O'Neill K, Riggs M, Wigler M. Characterization of ROS1 cDNA from a human glioblastoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 87: 4799-803. PMID 2352949 DOI: 10.1073/Pnas.87.12.4799 |
0.396 |
|
| 1990 |
Xu HP, Riggs M, Rodgers L, Wigler M. A gene from S. pombe with homology to E. coli RNAse III blocks conjugation and sporulation when overexpressed in wild type cells. Nucleic Acids Research. 18: 5304. PMID 2205842 DOI: 10.1093/Nar/18.17.5304 |
0.322 |
|
| 1990 |
Field J, Vojtek A, Ballester R, Bolger G, Colicelli J, Ferguson K, Gerst J, Kataoka T, Michaeli T, Powers S, Riggs M, Rodgers L, Wieland I, Wheland B, Wigler M. Cloning and characterization of CAP, the S. cerevisiae gene encoding the 70 kd adenylyl cyclase-associated protein Cell. 61: 319-327. PMID 2184942 DOI: 10.1016/0092-8674(90)90812-S |
0.307 |
|
| 1990 |
Ballester R, Marchuk D, Boguski M, Saulino A, Letcher R, Wigler M, Collins F. The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell. 63: 851-9. PMID 2121371 DOI: 10.1016/0092-8674(90)90151-4 |
0.421 |
|
| 1990 |
Colicelli J, Field J, Ballester R, Chester N, Young D, Wigler M. Mutational mapping of RAS-responsive domains of the Saccharomyces cerevisiae adenylyl cyclase. Molecular and Cellular Biology. 10: 2539-43. PMID 2111437 DOI: 10.1128/MCB.10.6.2539 |
0.709 |
|
| 1990 |
Xu HP, Wang Y, Riggs M, Rodgers L, Wigler M. Biological activity of the mammalian RAP genes in yeast. Cell Regulation. 1: 763-9. PMID 1983087 |
0.329 |
|
| 1989 |
Ballester R, Michaeli T, Ferguson K, Xu HP, McCormick F, Wigler M. Genetic analysis of mammalian GAP expressed in yeast. Cell. 59: 681-6. PMID 2684416 DOI: 10.1016/0092-8674(89)90014-7 |
0.4 |
|
| 1989 |
Young D, Riggs M, Field J, Vojtek A, Broek D, Wigler M. The adenylyl cyclase gene from Schizosaccharomyces pombe. Proceedings of the National Academy of Sciences of the United States of America. 86: 7989-93. PMID 2682634 DOI: 10.1073/PNAS.86.20.7989 |
0.72 |
|
| 1989 |
Colicelli J, Birchmeier C, Michaeli T, O'Neill K, Riggs M, Wigler M. Isolation and characterization of a mammalian gene encoding a high-affinity cAMP phosphodiesterase. Proceedings of the National Academy of Sciences of the United States of America. 86: 3599-603. PMID 2542941 DOI: 10.1073/Pnas.86.10.3599 |
0.428 |
|
| 1988 |
Toda T, Cameron S, Sass P, Wigler M. SCH9, a gene of Saccharomyces cerevisiae that encodes a protein distinct from, but functionally and structurally related to, cAMP-dependent protein kinase catalytic subunits. Genes & Development. 2: 517-27. PMID 3290050 DOI: 10.1101/Gad.2.5.517 |
0.447 |
|
| 1988 |
Cameron S, Levin L, Zoller M, Wigler M. cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae. Cell. 53: 555-66. PMID 2836063 DOI: 10.1016/0092-8674(88)90572-7 |
0.377 |
|
| 1988 |
Young D, O'Neill K, Jessell T, Wigler M. Characterization of the rat mas oncogene and its high-level expression in the hippocampus and cerebral cortex of rat brain. Proceedings of the National Academy of Sciences of the United States of America. 85: 5339-42. PMID 2455902 DOI: 10.1073/Pnas.85.14.5339 |
0.716 |
|
| 1987 |
Broek D, Toda T, Michaeli T, Levin L, Birchmeier C, Zoller M, Powers S, Wigler M. The S. cerevisiae CDC25 gene product regulates the RAS/adenylate cyclase pathway. Cell. 48: 789-99. PMID 3545497 DOI: 10.1016/0092-8674(87)90076-6 |
0.474 |
|
| 1987 |
Toda T, Cameron S, Sass P, Zoller M, Wigler M. Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase. Cell. 50: 277-87. PMID 3036373 DOI: 10.1016/0092-8674(87)90223-6 |
0.416 |
|
| 1987 |
Birchmeier C, Sharma S, Wigler M. Expression and rearrangement of the ROS1 gene in human glioblastoma cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 9270-4. PMID 2827175 DOI: 10.1073/Pnas.84.24.9270 |
0.393 |
|
| 1987 |
Nikawa J, Sass P, Wigler M. Cloning and characterization of the low-affinity cyclic AMP phosphodiesterase gene of Saccharomyces cerevisiae. Molecular and Cellular Biology. 7: 3629-36. PMID 2824992 |
0.303 |
|
| 1986 |
Young D, Waitches G, Birchmeier C, Fasano O, Wigler M. Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains. Cell. 45: 711-9. PMID 3708691 DOI: 10.1016/0092-8674(86)90785-3 |
0.744 |
|
| 1986 |
Powers S, Michaelis S, Broek D, Santa Anna S, Field J, Herskowitz I, Wigler M. RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Cell. 47: 413-22. PMID 3533274 DOI: 10.1016/0092-8674(86)90598-2 |
0.41 |
|
| 1986 |
Birchmeier C, Young D, Wigler M. Characterization of two new human oncogenes. Cold Spring Harbor Symposia On Quantitative Biology. 51: 993-1000. PMID 3472773 DOI: 10.1101/SQB.1986.051.01.113 |
0.657 |
|
| 1986 |
Sass P, Field J, Nikawa J, Toda T, Wigler M. Cloning and characterization of the high-affinity cAMP phosphodiesterase of Saccharomyces cerevisiae. Proceedings of the National Academy of Sciences of the United States of America. 83: 9303-7. PMID 3025832 DOI: 10.1073/Pnas.83.24.9303 |
0.443 |
|
| 1985 |
Gross M, Sweet RW, Sathe G, Yokoyama S, Fasano O, Goldfarb M, Wigler M, Rosenberg M. Purification and characterization of human H-ras proteins expressed in Escherichia coli. Molecular and Cellular Biology. 5: 1015-24. PMID 3923330 DOI: 10.1128/Mcb.5.5.1015 |
0.555 |
|
| 1985 |
Broek D, Samiy N, Fasano O, Fujiyama A, Tamanoi F, Northup J, Wigler M. Differential activation of yeast adenylate cyclase by wild-type and mutant RAS proteins. Cell. 41: 763-9. PMID 3891097 DOI: 10.1016/S0092-8674(85)80057-X |
0.404 |
|
| 1985 |
Toda T, Uno I, Ishikawa T, Powers S, Kataoka T, Broek D, Cameron S, Broach J, Matsumoto K, Wigler M. In yeast, RAS proteins are controlling elements of adenylate cyclase. Cell. 40: 27-36. PMID 2981630 DOI: 10.1016/0092-8674(85)90305-8 |
0.321 |
|
| 1985 |
Kataoka T, Powers S, Cameron S, Fasano O, Goldfarb M, Broach J, Wigler M. Functional homology of mammalian and yeast RAS genes. Cell. 40: 19-26. PMID 2981628 DOI: 10.1016/0092-8674(85)90304-6 |
0.587 |
|
| 1985 |
Kataoka T, Broek D, Wigler M. DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclase. Cell. 43: 493-505. PMID 2934138 DOI: 10.1016/0092-8674(85)90179-5 |
0.427 |
|
| 1985 |
Birchmeier C, Broek D, Wigler M. ras proteins can induce meiosis in Xenopus oocytes. Cell. 43: 615-21. PMID 2416466 DOI: 10.1016/0092-8674(85)90233-8 |
0.365 |
|
| 1984 |
Tamanoi F, Walsh M, Kataoka T, Wigler M. A product of yeast RAS2 gene is a guanine nucleotide binding protein. Proceedings of the National Academy of Sciences of the United States of America. 81: 6924-8. PMID 6438624 DOI: 10.1073/Pnas.81.22.6924 |
0.426 |
|
| 1984 |
Powers S, Kataoka T, Fasano O, Goldfarb M, Strathern J, Broach J, Wigler M. Genes in S. cerevisiae encoding proteins with domains homologous to the mammalian ras proteins. Cell. 36: 607-12. PMID 6365329 DOI: 10.1016/0092-8674(84)90340-4 |
0.603 |
|
| 1984 |
Fasano O, Aldrich T, Tamanoi F, Taparowsky E, Furth M, Wigler M. Analysis of the transforming potential of the human H-ras gene by random mutagenesis. Proceedings of the National Academy of Sciences of the United States of America. 81: 4008-12. PMID 6330729 DOI: 10.1073/Pnas.81.13.4008 |
0.707 |
|
| 1984 |
Kataoka T, Powers S, McGill C, Fasano O, Strathern J, Broach J, Wigler M. Genetic analysis of yeast RAS1 and RAS2 genes. Cell. 37: 437-45. PMID 6327067 DOI: 10.1016/0092-8674(84)90374-X |
0.331 |
|
| 1983 |
Taparowsky E, Shimizu K, Goldfarb M, Wigler M. Structure and activation of the human N-ras gene. Cell. 34: 581-6. PMID 6616621 DOI: 10.1016/0092-8674(83)90390-2 |
0.737 |
|
| 1983 |
Barker D, McCoy M, Weinberg R, Goldfarb M, Wigler M, Burt R, Gardner E, White R. A test of the role of two oncogenes in inherited predisposition to colon cancer. Molecular Biology & Medicine. 1: 199-206. PMID 6594558 |
0.486 |
|
| 1983 |
Shimizu K, Goldfarb M, Suard Y, Perucho M, Li Y, Kamata T, Feramisco J, Stavnezer E, Fogh J, Wigler MH. Three human transforming genes are related to the viral ras oncogenes. Proceedings of the National Academy of Sciences of the United States of America. 80: 2112-6. PMID 6572964 DOI: 10.1073/Pnas.80.8.2112 |
0.542 |
|
| 1983 |
Shimizu K, Birnbaum D, Ruley MA, Fasano O, Suard Y, Edlund L, Taparowsky E, Goldfarb M, Wigler M. Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1. Nature. 304: 497-500. PMID 6308465 DOI: 10.1038/304497A0 |
0.737 |
|
| 1983 |
Fasano O, Taparowsky E, Fiddes J, Wigler M, Goldfarb M. Sequence and structure of the coding region of the human H-ras-1 gene from T24 bladder carcinoma cells. Journal of Molecular and Applied Genetics. 2: 173-80. PMID 6308118 |
0.532 |
|
| 1983 |
Shimizu K, Goldfarb M, Perucho M, Wigler M. Isolation and preliminary characterization of the transforming gene of a human neuroblastoma cell line. Proceedings of the National Academy of Sciences of the United States of America. 80: 383-7. PMID 6300838 DOI: 10.1073/Pnas.80.2.383 |
0.605 |
|
| 1982 |
Taparowsky E, Suard Y, Fasano O, Shimizu K, Goldfarb M, Wigler M. Activation of the T24 bladder carcinoma transforming gene is linked to a single amino acid change. Nature. 300: 762-5. PMID 7177195 DOI: 10.1038/300762A0 |
0.746 |
|
| 1982 |
Goldfarb M, Shimizu K, Perucho M, Wigler M. Isolation and preliminary characterization of a human transforming gene from T24 bladder carcinoma cells. Nature. 296: 404-9. PMID 7063039 DOI: 10.1038/296404A0 |
0.565 |
|
| 1981 |
Wigler M, Levy D, Perucho M. The somatic replication of DNA methylation. Cell. 24: 33-40. PMID 6263490 DOI: 10.1016/0092-8674(81)90498-0 |
0.317 |
|
| 1981 |
Perucho M, Goldfarb M, Shimizu K, Lama C, Fogh J, Wigler M. Human-tumor-derived cell lines contain common and different transforming genes. Cell. 27: 467-76. PMID 6101201 DOI: 10.1016/0092-8674(81)90388-3 |
0.602 |
|
| 1980 |
Perucho M, Hanahan D, Wigler M. Genetic and physical linkage of exogenous sequences in transformed cells. Cell. 22: 309-17. PMID 6253083 DOI: 10.1016/0092-8674(80)90178-6 |
0.331 |
|
| 1980 |
Wigler M, Perucho M, Kurtz D, Dana S, Pellicer A, Axel R, Silverstein S. Transformation of mammalian cells with an amplifiable dominant-acting gene. Proceedings of the National Academy of Sciences of the United States of America. 77: 3567-70. PMID 6251468 DOI: 10.1073/pnas.77.6.3567 |
0.58 |
|
| 1980 |
Hanahan D, Lane D, Lipsich L, Wigler M, Botchan M. Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell. Cell. 21: 127-39. PMID 6250708 DOI: 10.1016/0092-8674(80)90120-8 |
0.37 |
|
| 1980 |
Perucho M, Hanahan D, Lipsich L, Wigler M. Isolation of the chicken thymidine kinase gene by plasmid rescue. Nature. 285: 207-10. PMID 6246445 DOI: 10.1038/285207A0 |
0.399 |
|
| 1979 |
Wold B, Wigler M, Lacy E, Maniatis T, Silverstein S, Axel R. Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proceedings of the National Academy of Sciences of the United States of America. 76: 5684-8. PMID 293672 DOI: 10.1073/pnas.76.11.5684 |
0.704 |
|
| 1979 |
Wigler M, Pellicer A, Silverstein S, Axel R, Urlaub G, Chasin L. DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 76: 1373-6. PMID 286319 DOI: 10.1073/Pnas.76.3.1373 |
0.538 |
|
| 1979 |
Wigler M, Sweet R, Sim GK, Wold B, Pellicer A, Lacy E, Maniatis T, Silverstein S, Axel R. Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell. 16: 777-85. PMID 222468 DOI: 10.1016/0092-8674(79)90093-X |
0.728 |
|
| 1978 |
Wigler M, DeFeo D, Weinstein IB. Induction of plasminogen activator in cultured cells by macrocyclic plant diterpene esters and other agents related to tumor promotion. Cancer Research. 38: 1434-7. PMID 639070 |
0.402 |
|
| 1978 |
Silverstein S, Wigler M, Pellicer A, Axel R. Identification of sequences coding for thymidine kinase in herpes simplex virus and transformed cell DNA. Iarc Scientific Publications. 501-8. PMID 221354 |
0.524 |
|
| 1978 |
Wigler M, Pellicer A, Silverstein S, Axel R. Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell. 14: 725-31. PMID 210957 DOI: 10.1016/0092-8674(78)90254-4 |
0.603 |
|
| 1978 |
Pellicer A, Wigler M, Axel R, Silverstein S. The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell. 14: 133-41. PMID 208776 DOI: 10.1016/0092-8674(78)90308-2 |
0.631 |
|
| 1977 |
Viaje A, Slaga TJ, Wigler M, Weinstein IB. Effects of antiinflammatory agents on mouse skin tumor promotion, epidermal DNA synthesis, phorbol ester-induced cellular proliferation, and production of plasminogen activator. Cancer Research. 37: 1530-6. PMID 856468 |
0.422 |
|
| 1977 |
Wigler M, Silverstein S, Lee LS, Pellicer A, Cheng Yc, Axel R. Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell. 11: 223-32. PMID 194704 DOI: 10.1016/0092-8674(77)90333-6 |
0.613 |
|
| 1977 |
Weinstein IB, Wigler M. Cell culture studies provide new information on tumour promoters Nature. 270: 659-660. DOI: 10.1038/270659A0 |
0.426 |
|
| 1976 |
Wigler M, Weinstein IB. Tumour promotor induces plasminogen activator. Nature. 259: 232-3. PMID 1250353 DOI: 10.1038/259232a0 |
0.332 |
|
| 1976 |
Wigler MH, Axel R. Nucleosomes in metaphase chromosomes. Nucleic Acids Research. 3: 1463-71. PMID 958895 DOI: 10.1093/nar/3.6.1463 |
0.458 |
|
| 1976 |
Wigler MH, Neugut AI, Weinstein IB. Enucleation of mammalian cells in suspension. Methods in Cell Biology. 14: 87-93. PMID 794633 |
0.38 |
|
| 1976 |
Weinstein IB, Wigler M, Stadler U. Analysis of the mechanism of chemical carcinogenesis in epithelial cell cultures Iarc (International Agency For Research On Cancer) Scientific Publications. 355-387. |
0.349 |
|
| 1976 |
Weinstein IB, Wigler MH. Suppression of plasminogen activator: a novel property of glucocorticoids Clinical Research. 24: 463A. |
0.333 |
|
| 1975 |
Wigler MH, Weinstein IB. A preparative method for obtaining enucleated mammalian cells. Biochemical and Biophysical Research Communications. 63: 669-74. PMID 1169063 DOI: 10.1016/S0006-291X(75)80436-0 |
0.376 |
|
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