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Michael R. Botchan - Publications

Affiliations: 
Molecular & Cell Biology University of California, Berkeley, Berkeley, CA, United States 
Area:
Eukaryote DNA replication and control of S phase
Website:
http://mcb.berkeley.edu/index.php?option=com_mcbfaculty&name=botchanm
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140 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Parker MW, Kao JA, Huang A, Berger JM, Botchan MR. Molecular determinants of phase separation for DNA replication licensing factors. Elife. 10. PMID 34951585 DOI: 10.7554/eLife.70535  0.785
2021 Attali I, Botchan MR, Berger JM. Structural Mechanisms for Replicating DNA in Eukaryotes. Annual Review of Biochemistry. PMID 33784179 DOI: 10.1146/annurev-biochem-090120-125407  0.337
2019 Parker MW, Bell M, Mir M, Kao JA, Darzacq X, Botchan MR, Berger JM. A new class of disordered elements controls DNA replication through initiator self-assembly. Elife. 8. PMID 31560342 DOI: 10.7554/Elife.48562  0.802
2019 Eickhoff P, Kose HB, Martino F, Petojevic T, Abid Ali F, Locke J, Tamberg N, Nans A, Berger JM, Botchan MR, Yardimci H, Costa A. Molecular Basis for ATP-Hydrolysis-Driven DNA Translocation by the CMG Helicase of the Eukaryotic Replisome. Cell Reports. 28: 2673-2688.e8. PMID 31484077 DOI: 10.1016/J.Celrep.2019.07.104  0.517
2019 Parker MW, Bell M, Mir M, Kao JA, Darzacq X, Botchan MR, Berger JM. Author response: A new class of disordered elements controls DNA replication through initiator self-assembly Elife. DOI: 10.7554/Elife.48562.024  0.766
2019 Botchan MR, Costa A. Decision letter: A conserved Mcm4 motif is required for Mcm2-7 double-hexamer formation and origin DNA unwinding Elife. DOI: 10.7554/Elife.45538.026  0.468
2018 Bleichert F, Leitner A, Aebersold R, Botchan MR, Berger JM. Conformational control and DNA-binding mechanism of the metazoan origin recognition complex. Proceedings of the National Academy of Sciences of the United States of America. PMID 29899147 DOI: 10.1073/Pnas.1806315115  0.55
2017 Greider C, Hopkins N, Steitz J, Amon A, Asai D, Barres B, Bass B, Bassler B, Birgeneau R, Bjorkman P, Botchan M, Brugge J, Cech T, Colwell R, Craig N, et al. Not just Salk. Science (New York, N.Y.). 357: 1105-1106. PMID 28912235 DOI: 10.1126/Science.Aao6221  0.565
2017 Bleichert F, Botchan MR, Berger JM. Mechanisms for initiating cellular DNA replication. Science (New York, N.Y.). PMID 28209641 DOI: 10.1126/Science.Aah6317  0.538
2017 Parker MW, Botchan MR, Berger JM. Mechanisms and regulation of DNA replication initiation in eukaryotes. Critical Reviews in Biochemistry and Molecular Biology. 1-41. PMID 28094588 DOI: 10.1080/10409238.2016.1274717  0.566
2015 Bleichert F, Botchan MR, Berger JM. Crystal structure of the eukaryotic origin recognition complex. Nature. 519: 321-6. PMID 25762138 DOI: 10.1038/Nature14239  0.482
2015 Petojevic T, Pesavento JJ, Costa A, Liang J, Wang Z, Berger JM, Botchan MR. Cdc45 (cell division cycle protein 45) guards the gate of the Eukaryote Replisome helicase stabilizing leading strand engagement. Proceedings of the National Academy of Sciences of the United States of America. 112: E249-58. PMID 25561522 DOI: 10.1073/Pnas.1422003112  0.492
2014 Blanchard DP, Georlette D, Antoszewski L, Botchan MR. Chromatin reader L(3)mbt requires the Myb-MuvB/DREAM transcriptional regulatory complex for chromosomal recruitment. Proceedings of the National Academy of Sciences of the United States of America. 111: E4234-43. PMID 25249635 DOI: 10.1073/Pnas.1416321111  0.386
2014 Costa A, Renault L, Swuec P, Petojevic T, Pesavento JJ, Ilves I, MacLellan-Gibson K, Fleck RA, Botchan MR, Berger JM. DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome. Elife. 3: e03273. PMID 25117490 DOI: 10.7554/Elife.03273  0.53
2014 Costa A, Renault L, Swuec P, Petojevic T, Pesavento JJ, Ilves I, MacLellan-Gibson K, Fleck RA, Botchan MR, Berger JM. Author response: DNA binding polarity, dimerization, and ATPase ring remodeling in the CMG helicase of the eukaryotic replisome Elife. DOI: 10.7554/Elife.03273.013  0.426
2013 Bleichert F, Balasov M, Chesnokov I, Nogales E, Botchan MR, Berger JM. A Meier-Gorlin syndrome mutation in a conserved C-terminal helix of Orc6 impedes origin recognition complex formation. Elife. 2: e00882. PMID 24137536 DOI: 10.7554/Elife.00882  0.417
2013 Bell SD, Botchan MR. The minichromosome maintenance replicative helicase. Cold Spring Harbor Perspectives in Biology. 5: a012807. PMID 23881943 DOI: 10.1101/Cshperspect.A012807  0.406
2012 Ilves I, Tamberg N, Botchan MR. Checkpoint kinase 2 (Chk2) inhibits the activity of the Cdc45/MCM2-7/GINS (CMG) replicative helicase complex. Proceedings of the National Academy of Sciences of the United States of America. 109: 13163-70. PMID 22853956 DOI: 10.1073/Pnas.1211525109  0.479
2012 Lyubimov AY, Costa A, Bleichert F, Botchan MR, Berger JM. ATP-dependent conformational dynamics underlie the functional asymmetry of the replicative helicase from a minimalist eukaryote. Proceedings of the National Academy of Sciences of the United States of America. 109: 11999-2004. PMID 22778422 DOI: 10.1073/Pnas.1209406109  0.422
2012 Lewis PW, Sahoo D, Geng C, Bell M, Lipsick JS, Botchan MR. Drosophila lin-52 acts in opposition to repressive components of the Myb-MuvB/dREAM complex. Molecular and Cellular Biology. 32: 3218-27. PMID 22688510 DOI: 10.1128/Mcb.00432-12  0.614
2011 Harrison MM, Li XY, Kaplan T, Botchan MR, Eisen MB. Zelda binding in the early Drosophila melanogaster embryo marks regions subsequently activated at the maternal-to-zygotic transition. Plos Genetics. 7: e1002266. PMID 22028662 DOI: 10.1371/Journal.Pgen.1002266  0.657
2011 Costa A, Ilves I, Tamberg N, Petojevic T, Nogales E, Botchan MR, Berger JM. The structural basis for MCM2-7 helicase activation by GINS and Cdc45. Nature Structural & Molecular Biology. 18: 471-7. PMID 21378962 DOI: 10.1038/Nsmb.2004  0.489
2011 Kawabata T, Luebben SW, Yamaguchi S, Ilves I, Matise I, Buske T, Botchan MR, Shima N. Stalled fork rescue via dormant replication origins in unchallenged S phase promotes proper chromosome segregation and tumor suppression. Molecular Cell. 41: 543-53. PMID 21362550 DOI: 10.1016/J.Molcel.2011.02.006  0.417
2011 Botchan M, Berger J. DNA replication: making two forks from one prereplication complex. Molecular Cell. 40: 860-1. PMID 21172652 DOI: 10.1016/j.molcel.2010.12.014  0.427
2010 Harrison MM, Botchan MR, Cline TW. Grainyhead and Zelda compete for binding to the promoters of the earliest-expressed Drosophila genes. Developmental Biology. 345: 248-55. PMID 20599892 DOI: 10.1016/J.Ydbio.2010.06.026  0.733
2010 Gleick PH, Adams RM, Amasino RM, Anders E, Anderson DJ, Anderson WW, Anselin LE, Arroyo MK, Asfaw B, Ayala FJ, Bax A, Bebbington AJ, Bell G, Bennett MV, Bennetzen JL, ... ... Botchan MR, et al. Climate change and the integrity of science. Science (New York, N.Y.). 328: 689-90. PMID 20448167 DOI: 10.1126/Science.328.5979.689  0.512
2010 Ilves I, Petojevic T, Pesavento JJ, Botchan MR. Activation of the MCM2-7 helicase by association with Cdc45 and GINS proteins. Molecular Cell. 37: 247-58. PMID 20122406 DOI: 10.1016/J.Molcel.2009.12.030  0.547
2010 Botchan M, Berger J. DNA Replication: Making Two Forks from One Prereplication Complex Molecular Cell. 40: 860-861. DOI: 10.1016/J.Molcel.2010.12.014  0.52
2008 Clarey MG, Botchan M, Nogales E. Single particle EM studies of the Drosophila melanogaster origin recognition complex and evidence for DNA wrapping. Journal of Structural Biology. 164: 241-9. PMID 18824234 DOI: 10.1016/J.Jsb.2008.08.006  0.776
2007 Georlette D, Ahn S, MacAlpine DM, Cheung E, Lewis PW, Beall EL, Bell SP, Speed T, Manak JR, Botchan MR. Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb MuvB/dREAM complex in proliferating cells. Genes & Development. 21: 2880-96. PMID 17978103 DOI: 10.1101/Gad.1600107  0.674
2007 Beall EL, Lewis PW, Bell M, Rocha M, Jones DL, Botchan MR. Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb-Muv B. Genes & Development. 21: 904-19. PMID 17403774 DOI: 10.1101/gad.1516607  0.597
2007 Botchan M. Cell biology: A switch for S phase Nature. 445: 272-274. PMID 17230184 DOI: 10.1038/445272A  0.523
2006 Abbate EA, Voitenleitner C, Botchan MR. Structure of the papillomavirus DNA-tethering complex E2:Brd4 and a peptide that ablates HPV chromosomal association. Molecular Cell. 24: 877-89. PMID 17189190 DOI: 10.1016/J.Molcel.2006.11.002  0.786
2006 Clarey MG, Erzberger JP, Grob P, Leschziner AE, Berger JM, Nogales E, Botchan M. Nucleotide-dependent conformational changes in the DnaA-like core of the origin recognition complex. Nature Structural & Molecular Biology. 13: 684-90. PMID 16829958 DOI: 10.1038/Nsmb1121  0.775
2006 Moyer SE, Lewis PW, Botchan MR. Isolation of the Cdc45/Mcm2-7/GINS (CMG) complex, a candidate for the eukaryotic DNA replication fork helicase. Proceedings of the National Academy of Sciences of the United States of America. 103: 10236-41. PMID 16798881 DOI: 10.1073/Pnas.0602400103  0.823
2005 Remus D, Blanchette M, Rio DC, Botchan MR. CDK phosphorylation inhibits the DNA-binding and ATP-hydrolysis activities of the Drosophila origin recognition complex. The Journal of Biological Chemistry. 280: 39740-51. PMID 16188887 DOI: 10.1074/Jbc.M508515200  0.445
2005 Bandura JL, Beall EL, Bell M, Silver HR, Botchan MR, Calvi BR. humpty dumpty is required for developmental DNA amplification and cell proliferation in Drosophila. Current Biology : Cb. 15: 755-9. PMID 15854909 DOI: 10.1016/J.Cub.2005.02.063  0.522
2004 Lewis PW, Beall EL, Fleischer TC, Georlette D, Link AJ, Botchan MR. Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complex. Genes & Development. 18: 2929-40. PMID 15545624 DOI: 10.1101/Gad.1255204  0.643
2004 Abbate EA, Berger JM, Botchan MR. The X-ray structure of the papillomavirus helicase in complex with its molecular matchmaker E2. Genes & Development. 18: 1981-96. PMID 15289463 DOI: 10.1101/Gad.1220104  0.785
2004 Beall EL, Bell M, Georlette D, Botchan MR. Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replication. Genes & Development. 18: 1667-80. PMID 15256498 DOI: 10.1101/Gad.1206604  0.473
2004 Botchan M. Hitchhiking without covalent integration Cell. 117: 280-281. PMID 15109488 DOI: 10.1016/S0092-8674(04)00410-6  0.344
2004 Remus D, Beall EL, Botchan MR. DNA topology, not DNA sequence, is a critical determinant for Drosophila ORC-DNA binding. The Embo Journal. 23: 897-907. PMID 14765124 DOI: 10.1038/Sj.Emboj.7600077  0.554
2003 Chesnokov IN, Chesnokova ON, Botchan M. A cytokinetic function of Drosophila ORC6 protein resides in a domain distinct from its replication activity Proceedings of the National Academy of Sciences of the United States of America. 100: 9150-9155. PMID 12878722 DOI: 10.1073/Pnas.1633580100  0.483
2002 Beall EL, Manak JR, Zhou S, Bell M, Lipsick JS, Botchan MR. Role for a Drosophila Myb-containing protein complex in site-specific DNA replication. Nature. 420: 833-7. PMID 12490953 DOI: 10.1038/Nature01228  0.549
2002 Alexandrov AI, Botchan MR, Cozzarelli NR. Characterization of simian virus 40 T-antigen double hexamers bound to a replication fork. The active form of the helicase. The Journal of Biological Chemistry. 277: 44886-97. PMID 12244108 DOI: 10.1074/Jbc.M207022200  0.468
2002 Voitenleitner C, Botchan M. E1 protein of bovine papillomavirus type 1 interferes with E2 protein-mediated tethering of the viral DNA to mitotic chromosomes Journal of Virology. 76: 3440-3451. PMID 11884568 DOI: 10.1128/Jvi.76.7.3440-3451.2002  0.436
2001 Chesnokov I, Remus D, Botchan M. Functional analysis of mutant and wild-type Drosophila origin recognition complex. Proceedings of the National Academy of Sciences of the United States of America. 98: 11997-2002. PMID 11593009 DOI: 10.1073/Pnas.211342798  0.49
2001 Bielinsky AK, Blitzblau H, Beall EL, Ezrokhi M, Smith HS, Botchan MR, Gerbi SA. Origin recognition complex binding to a metazoan replication origin. Current Biology : Cb. 11: 1427-31. PMID 11566101 DOI: 10.1016/S0960-9822(01)00444-4  0.529
2001 Pflumm MF, Botchan MR. Orc mutants arrest in metaphase with abnormally condensed chromosomes. Development (Cambridge, England). 128: 1697-707. PMID 11290306  0.764
2000 Parker LM, Harris S, Gossen M, Botchan MR. The bovine papillomavirus E2 transactivator is stimulated by the E1 initiator through the E2 activation domain. Virology. 270: 430-43. PMID 10793002 DOI: 10.1006/Viro.2000.0257  0.404
2000 Adams MD, Celniker SE, Holt RA, Evans CA, Gocayne JD, Amanatides PG, Scherer SE, Li PW, Hoskins RA, Galle RF, George RA, Lewis SE, Richards S, Ashburner M, Henderson SN, ... ... Botchan MR, et al. The genome sequence of Drosophila melanogaster. Science (New York, N.Y.). 287: 2185-95. PMID 10731132 DOI: 10.1126/Science.287.5461.2185  0.305
1999 Harris SF, Botchan MR. Crystal structure of the human papillomavirus type 18 E2 activation domain. Science (New York, N.Y.). 284: 1673-7. PMID 10356398 DOI: 10.1126/Science.284.5420.1673  0.408
1999 Chesnokov I, Gossen M, Remus D, Botchan M. Assembly of functionally active Drosophila origin recognition complex from recombinant proteins. Genes & Development. 13: 1289-96. PMID 10346817 DOI: 10.1101/Gad.13.10.1289  0.55
1999 Fouts ET, Yu X, Egelman EH, Botchan MR. Biochemical and electron microscopic image analysis of the hexameric E1 helicase. The Journal of Biological Chemistry. 274: 4447-58. PMID 9933649 DOI: 10.1074/Jbc.274.7.4447  0.498
1998 Huang DW, Fanti L, Pak DT, Botchan MR, Pimpinelli S, Kellum R. Distinct cytoplasmic and nuclear fractions of Drosophila heterochromatin protein 1: their phosphorylation levels and associations with origin recognition complex proteins. The Journal of Cell Biology. 142: 307-18. PMID 9679132 DOI: 10.1083/Jcb.142.2.307  0.427
1998 Lehman CW, Botchan MR. Segregation of viral plasmids depends on tethering to chromosomes and is regulated by phosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 95: 4338-43. PMID 9539738 DOI: 10.1073/Pnas.95.8.4338  0.503
1998 Lim DA, Gossen M, Lehman CW, Botchan MR. Competition for DNA binding sites between the short and long forms of E2 dimers underlies repression in bovine papillomavirus type 1 DNA replication control. Journal of Virology. 72: 1931-40. PMID 9499046 DOI: 10.1128/Jvi.72.3.1931-1940.1998  0.533
1997 Pak DT, Pflumm M, Chesnokov I, Huang DW, Kellum R, Marr J, Romanowski P, Botchan MR. Association of the origin recognition complex with heterochromatin and HP1 in higher eukaryotes. Cell. 91: 311-23. PMID 9363940 DOI: 10.1016/S0092-8674(00)80415-8  0.786
1997 Abramova NA, Russell J, Botchan M, Li R. Interaction between replication protein A and p53 is disrupted after UV damage in a DNA repair-dependent manner Proceedings of the National Academy of Sciences of the United States of America. 94: 7186-7191. PMID 9207066 DOI: 10.1073/Pnas.94.14.7186  0.435
1997 Lehman CW, King DS, Botchan MR. A papillomavirus E2 phosphorylation mutant exhibits normal transient replication and transcription but is defective in transformation and plasmid retention. Journal of Virology. 71: 3652-65. PMID 9094639  0.302
1996 Gossen M, Pak DT, Botchan MR. Drosophila Homolog of Yeast ORC: Correction. Science (New York, N.Y.). 271: 1349b. PMID 17814025 DOI: 10.1126/Science.271.5254.1349B  0.315
1996 Chesnokov I, Chu WM, Botchan MR, Schmid CW. p53 inhibits RNA polymerase III-directed transcription in a promoter-dependent manner. Molecular and Cellular Biology. 16: 7084-8. PMID 8943363 DOI: 10.1128/Mcb.16.12.7084  0.567
1996 Botchan M. Coordinating DNA replication with cell division: Current status of the licensing concept Proceedings of the National Academy of Sciences of the United States of America. 93: 9997-10000. PMID 8816736 DOI: 10.1073/Pnas.93.19.9997  0.477
1996 Ferguson MK, Botchan MR. Genetic analysis of the activation domain of bovine papillomavirus protein E2: its role in transcription and replication. Journal of Virology. 70: 4193-9. PMID 8676438  0.333
1995 Russell J, Botchan MR. cis-Acting components of human papillomavirus (HPV) DNA replication: linker substitution analysis of the HPV type 11 origin. Journal of Virology. 69: 651-60. PMID 7815528  0.344
1995 Mendoza R, Gandhi L, Botchan MR. E1 recognition sequences in the bovine papillomavirus type 1 origin of DNA replication: interaction between half sites of the inverted repeats. Journal of Virology. 69: 3789-98. PMID 7745726  0.398
1995 Wyman C, Botchan M. DNA Replication: A familiar ring to DNA polymerase processivity Current Biology. 5: 334-337. PMID 7627541 DOI: 10.1016/S0960-9822(95)00065-0  0.521
1995 Gossen M, Pak DT, Hansen SK, Acharya JK, Botchan MR. A Drosophila homolog of the yeast origin recognition complex. Science (New York, N.Y.). 270: 1674-7. PMID 7502079 DOI: 10.1126/Science.270.5242.1674  0.486
1995 Ehrenhofer-Murray AE, Gossen M, Pak DT, Botchan MR, Rine J. Separation of origin recognition complex functions by cross-species complementation. Science (New York, N.Y.). 270: 1671-4. PMID 7502078 DOI: 10.1126/Science.270.5242.1671  0.451
1994 MacPherson P, Thorner L, Parker LM, Botchan M. The bovine papilloma virus E1 protein has ATPase activity essential to viral DNA replication and efficient transformation in cells Virology. 204: 403-408. PMID 8091670 DOI: 10.1006/Viro.1994.1544  0.505
1994 Park P, Copeland W, Yang L, Wang T, Botchan MR, Mohr IJ. The cellular DNA polymerase alpha-primase is required for papillomavirus DNA replication and associates with the viral E1 helicase. Proceedings of the National Academy of Sciences of the United States of America. 91: 8700-4. PMID 8078945 DOI: 10.1073/Pnas.91.18.8700  0.521
1994 Li R, Botchan MR. Acidic transcription factors alleviate nucleosome-mediated repression of DNA replication of bovine papillomavirus type 1. Proceedings of the National Academy of Sciences of the United States of America. 91: 7051-5. PMID 8041744 DOI: 10.1073/Pnas.91.15.7051  0.485
1994 Kaufman PD, Botchan MR. Assembly of nucleosomes: do multiple assembly factors mean multiple mechanisms? Current Opinion in Genetics & Development. 4: 229-35. PMID 8032200 DOI: 10.1016/S0959-437X(05)80049-8  0.473
1993 Thorner LK, Lim DA, Botchan MR. DNA-binding domain of bovine papillomavirus type 1 E1 helicase: structural and functional aspects. Journal of Virology. 67: 6000-14. PMID 8396665 DOI: 10.1128/Jvi.67.10.6000-6014.1993  0.513
1993 Li R, Botchan MR. The acidic transcriptional activation domains of VP16 and p53 bind the cellular replication protein A and stimulate in vitro BPV-1 DNA replication. Cell. 73: 1207-21. PMID 8390328 DOI: 10.1016/0092-8674(93)90649-B  0.428
1993 Yang L, Mohr I, Fouts E, Lim DA, Nohaile M, Botchan M. The E1 protein of bovine papilloma virus 1 is an ATP-dependent DNA helicase. Proceedings of the National Academy of Sciences of the United States of America. 90: 5086-90. PMID 8389467 DOI: 10.1073/Pnas.90.11.5086  0.545
1993 Lentz MR, Pak D, Mohr I, Botchan MR. The E1 replication protein of bovine papillomavirus type 1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site. Journal of Virology. 67: 1414-23. PMID 8382303 DOI: 10.1128/Jvi.67.3.1414-1423.1993  0.474
1993 Li R, Yang L, Fouts E, Botchan MR. Site-specific DNA-binding proteins important for replication and transcription have multiple activities. Cold Spring Harbor Symposia On Quantitative Biology. 58: 403-13. PMID 7956054 DOI: 10.1101/Sqb.1993.058.01.047  0.49
1992 Kim SJ, Onwuta US, Lee YI, Li R, Botchan MR, Robbins PD. The retinoblastoma gene product regulates Sp1-mediated transcription. Molecular and Cellular Biology. 12: 2455-63. PMID 1588949 DOI: 10.1128/Mcb.12.6.2455  0.301
1992 Bream GL, Vaillancourt P, Botchan MR. A constitutive enhancer in the bovine papillomavirus upstream regulatory region shares genetic elements with the viral P1 promoter. Journal of Virology. 66: 7319-27. PMID 1331522 DOI: 10.1128/Jvi.66.12.7319-7327.1992  0.386
1992 Maulbecker C, Mohr I, Gluzman Y, Bartholomew J, Botchan M. A deletion in the simian virus 40 large T antigen impairs lytic replication in monkey cells in vivo but enhances DNA replication in vitro: New complementation function of T antigen Journal of Virology. 66: 2195-2207. PMID 1312627 DOI: 10.1128/Jvi.66.4.2195-2207.1992  0.455
1991 Li R, Knight JD, Jackson SP, Tjian R, Botchan MR. Direct interaction between Sp1 and the BPV enhancer E2 protein mediates synergistic activation of transcription. Cell. 65: 493-505. PMID 1850324 DOI: 10.1016/0092-8674(91)90467-D  0.603
1991 Knight JD, Li R, Botchan M. The activation domain of the bovine papillomavirus E2 protein mediates association of DNA-bound dimers to form DNA loops. Proceedings of the National Academy of Sciences of the United States of America. 88: 3204-8. PMID 1849647 DOI: 10.1073/Pnas.88.8.3204  0.516
1991 Yang L, Mohr I, Li R, Nottoli T, Sun S, Botchan M. Transcription factor E2 regulates BPV-1 DNA replication in vitro by direct protein-protein interaction Cold Spring Harbor Symposia On Quantitative Biology. 56: 335-346. PMID 1668086 DOI: 10.1101/Sqb.1991.056.01.040  0.47
1991 Yang L, Li R, Mohr IJ, Clark R, Botchan MR. Activation of BPV-1 replication in vitro by the transcription factor E2. Nature. 353: 628-32. PMID 1656277 DOI: 10.1038/353628A0  0.517
1990 Mohr IJ, Clark R, Sun S, Androphy EJ, MacPherson P, Botchan MR. Targeting the E1 replication protein to the papillomavirus origin of replication by complex formation with the E2 transactivator. Science (New York, N.Y.). 250: 1694-9. PMID 2176744 DOI: 10.1126/Science.2176744  0.465
1990 Yang L, Botchan M. Replication of bovine papillomavirus type 1 DNA initiates within an E2-responsive enhancer element Journal of Virology. 64: 5903-5911. PMID 2173772  0.443
1990 Sun S, Thorner L, Lentz M, Macpherson P, Botchan M. Identification of a 68-kilodalton nuclear ATP-binding phosphoprotein encoded by bovine papillomavirus type 1 Journal of Virology. 64: 5093-5105. PMID 2168988 DOI: 10.1128/Jvi.64.10.5093-5105.1990  0.44
1990 Vaillancourt P, Nottoli T, Choe J, Botchan MR. The E2 transactivator of bovine papillomavirus type 1 is expressed from multiple promoters. Journal of Virology. 64: 3927-37. PMID 2164604 DOI: 10.1128/Jvi.64.8.3927-3937.1990  0.36
1990 Stenlund A, Botchan MR. The E2 trans-activator can act as a repressor by interfering with a cellular transcription factor. Genes & Development. 4: 123-36. PMID 2155158 DOI: 10.1101/Gad.4.1.123  0.348
1989 Li R, Knight J, Bream G, Stenlund A, Botchan M. Specific recognition nucleotides and their DNA context determine the affinity of E2 protein for 17 binding sites in the BPV-1 genome Genes & Development. 3: 510-526. PMID 2542129 DOI: 10.1101/Gad.3.4.510  0.508
1989 Choe J, Vaillancourt P, Stenlund A, Botchan M. Bovine papillomavirus type 1 encodes two forms of a transcriptional repressor: Structural and functional analysis of new viral cDNAs Journal of Virology. 63: 1743-1755. PMID 2538655 DOI: 10.1128/Jvi.63.4.1743-1755.1989  0.426
1988 Thorner L, Bucay N, Choe J, Botchan M. The product of the bovine papillomavirus type 1 modulator gene (M) is a phosphoprotein Journal of Virology. 62: 2474-2482. PMID 2836626 DOI: 10.1128/Jvi.62.7.2474-2482.1988  0.367
1987 Gish WR, Botchan MR. Simian virus 40-transformed human cells that express large T antigens defective for viral DNA replication. Journal of Virology. 61: 2864-76. PMID 3039174  0.367
1987 Stenlund A, Bream GL, Botchan MR. A promoter with an internal regulatory domain is part of the origin of replication in BPV-1. Science (New York, N.Y.). 236: 1666-71. PMID 3037693 DOI: 10.1126/Science.3037693  0.51
1986 Bullock P, Miller J, Botchan M. Effects of poly[d(pGpT).d(pApC)] and poly[d(pCpG).d(pCpG)] repeats on homologous recombination in somatic cells Molecular and Cellular Biology. 6: 3948-3953. PMID 3025620 DOI: 10.1128/Mcb.6.11.3948  0.32
1986 Carey MF, Singh K, Botchan M, Cozzarelli NR. Induction of specific transcription by RNA polymerase III in transformed cells. Molecular and Cellular Biology. 6: 3068-76. PMID 3023960 DOI: 10.1128/Mcb.6.9.3068  0.354
1986 Robbins PD, Rio DC, Botchan MR. trans Activation of the simian virus 40 enhancer. Molecular and Cellular Biology. 6: 1283-95. PMID 3023880 DOI: 10.1128/Mcb.6.4.1283  0.335
1986 Berg LJ, Singh K, Botchan M. Complementation of a bovine papilloma virus low-copy-number mutant: Evidence for a temporal requirement of the complementing gene Molecular and Cellular Biology. 6: 859-869. PMID 3022134 DOI: 10.1128/Mcb.6.3.859  0.664
1986 Berg L, Lusky M, Stenlund A, Botchan MR. Repression of bovine papilloma virus replication is mediated by a virally encoded trans-acting factor. Cell. 46: 753-62. PMID 3017567 DOI: 10.1016/0092-8674(86)90351-X  0.693
1986 Botchan M, Berg L, Reynolds J, Lusky M. The bovine papillomavirus replicon Ciba Foundation Symposium. 120: 53-67. PMID 3013526  0.603
1986 Lusky M, Botchan MR. Transient replication of bovine papilloma virus type 1 plasmids: cis and trans requirements. Proceedings of the National Academy of Sciences of the United States of America. 83: 3609-13. PMID 3012521 DOI: 10.1073/Pnas.83.11.3609  0.454
1985 Miller J, Bullock P, Botchan M. Simian virus 40 T antigen is required for viral excision from chromosomes. Proceedings of the National Academy of Sciences of the United States of America. 81: 7534-8. PMID 6095304 DOI: 10.1073/Pnas.81.23.7534  0.407
1985 Perez CF, Botchan MR, Tobias CA. DNA-mediated gene transfer efficiency is enhanced by ionizing and ultraviolet irradiation of rodent cells in vitro. I. Kinetics of enhancement. Radiation Research. 104: 200-13. PMID 3001817 DOI: 10.2307/3576616  0.377
1985 Bullock P, Champoux JJ, Botchan M. Association of crossover points with topoisomerase I cleavage sites: A model for nonhomologous recombination Science. 230: 954-958. PMID 2997924 DOI: 10.1126/Science.2997924  0.487
1985 DuBridge RB, Lusky M, Botchan MR, Calos MP. Amplification of a bovine papillomavirus-simian virus 40 chimera. Journal of Virology. 56: 625-7. PMID 2997482 DOI: 10.1128/Jvi.56.2.625-627.1985  0.372
1985 Lusky M, Botchan MR. Genetic analysis of bovine papillomavirus type 1 trans-acting replication factors. Journal of Virology. 53: 955-65. PMID 2983102  0.314
1985 Singh K, Carey M, Saragosti S, Botchan M. Expression of enhanced levels of small RNA polymerase III transcripts encoded by the B2 repeats in simian virus 40-transformed mouse cells. Nature. 314: 553-6. PMID 2581137 DOI: 10.1038/314553A0  0.369
1984 Bullock P, Forrester W, Botchan M. DNA sequence studies of simian virus 40 chromosomal excision and integration in rat cells. Journal of Molecular Biology. 174: 55-84. PMID 6325709 DOI: 10.1016/0022-2836(84)90365-6  0.488
1984 Weiher H, Botchan MR. An enhancer sequence from bovine papilloma virus DNA consists of two essential regions. Nucleic Acids Research. 12: 2901-16. PMID 6324133 DOI: 10.1093/Nar/12.6.2901  0.489
1984 Lusky M, Botchan MR. Characterization of the bovine papilloma virus plasmid maintenance sequences. Cell. 36: 391-401. PMID 6319020 DOI: 10.1016/0092-8674(84)90232-0  0.389
1984 Kriegler M, Perez CF, Hardy C, Botchan M. Transformation mediated by the SV40 T antigens: Separation of the overlapping SV40 early genes with a retroviral vector Cell. 38: 483-491. PMID 6088084 DOI: 10.1016/0092-8674(84)90503-8  0.323
1984 Weiher H, Botchan MR. An enhancer sequence from bovine papilloma virus DNA consists of two essential regions Nucleic Acids Research. 12: 2901-2916. DOI: 10.1093/nar/12.6.2901  0.341
1983 Calos MP, Lebkowski JS, Botchan MR. High mutation frequency in DNA transfected into mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 80: 3015-9. PMID 6574469 DOI: 10.1073/Pnas.80.10.3015  0.461
1983 Lusky M, Berg L, Weiher H, Botchan M. Bovine papilloma virus contains an activator of gene expression at the distal end of the early transcription unit. Molecular and Cellular Biology. 3: 1108-22. PMID 6308425 DOI: 10.1128/Mcb.3.6.1108  0.68
1983 Kriegler M, Botchan M. Enhanced transformation by a simian virus 40 recombinant virus containing a Harvey murine sarcoma virus long terminal repeat. Molecular and Cellular Biology. 3: 325-39. PMID 6302472 DOI: 10.1128/MCB.3.3.325  0.327
1982 Conrad SE, Liu CP, Botchan MR. Fragment spanning the SV40 replication origin is the only DNA sequence required in cis for viral excision. Science (New York, N.Y.). 218: 1223-5. PMID 6293055 DOI: 10.1126/Science.6293055  0.467
1982 Conrad SE, Botchan MR. Isolation and characterization of human DNA fragments with nucleotide sequence homologies with the simian virus 40 regulatory region. Molecular and Cellular Biology. 2: 949-65. PMID 6290874 DOI: 10.1128/Mcb.2.8.949  0.474
1981 Lusky M, Botchan M. Inhibition of SV40 replication in simian cells by specific pBR322 DNA sequences. Nature. 293: 79-81. PMID 6267479 DOI: 10.1038/293079A0  0.508
1980 Hanahan D, Lane D, Lipsich L, Wigler M, Botchan M. Characteristics of an SV40-plasmid recombinant and its movement into and out of the genome of a murine cell. Cell. 21: 127-39. PMID 6250708 DOI: 10.1016/0092-8674(80)90120-8  0.461
1980 Botchan M, Stringer J, Mitchison T, Sambrook J. Integration and excision of SV40 DNA from the chromosome of a transformed cell Cell. 20: 143-152. PMID 6248231 DOI: 10.1016/0092-8674(80)90242-1  0.482
1980 Sambrook J, Botchan M, Hu SL, Mitchison T, Stringer J. Integration of viral DNA sequences in cells transformed by adenovirus 2 or SV40 Proceedings of the Royal Society of London - Biological Sciences. 210: 423-435. PMID 6109303 DOI: 10.1098/Rspb.1980.0144  0.433
1979 Sambrook J, Greene R, Stringer J, Mitchison T, Hu SL, Botchan M. Analysis of the sites of integration of viral DNA sequences in rat cells transformed by adenovirus 2 or SV40 Symposia On Quantitative Biology. 44: 569-584. PMID 6253158 DOI: 10.1101/Sqb.1980.044.01.059  0.315
1979 Graessmann A, Graessmann M, Topp WC, Botchan M. Retransformation of a simian virus 40 revertant cell line, which is resistant to viral and DNA infections, by microinjection of viral DNA. Journal of Virology. 32: 989-994. DOI: 10.1128/jvi.32.3.989-994.1979  0.327
1978 Kucherlapati R, Hwang SP, Shimizu N, McDougall JK, Botchan MR. Another chromosomal assignment for a simian virus 40 integration site in human cells. Proceedings of the National Academy of Sciences of the United States of America. 75: 4460-4. PMID 212753 DOI: 10.1073/Pnas.75.9.4460  0.342
1978 Steinberg B, Pollack R, Topp W, Botchan M. Isolation and characterization of T antigen-negative revertants from a line of transformed rat cells containing one copy of the SV40 genome. Cell. 13: 19-32. PMID 202400 DOI: 10.1016/0092-8674(78)90134-4  0.426
1977 Bukhari AI, Froshauer S, Botchan M. Ends of bacteriophage mu DNA. Nature. 264: 580-3. PMID 1004602 DOI: 10.1038/264580A0  0.513
1976 Botchan M, Topp W, Sambrook J. The arrangement of simian virus 40 sequences in the DNA of transformed cells Cell. 9: 269-287. PMID 184963 DOI: 10.1016/0092-8674(76)90118-5  0.507
1974 Botchan MR. Bovine satellite I DNA consists of repetitive units 1,400 base pairs in length. Nature. 251: 288-92. PMID 4610397 DOI: 10.1038/251288A0  0.497
1974 Botchan M, Ozanne B, Sugden B, Sharp PA, Sambrook J. Viral DNA in transformed cells. III. The amounts of different regions of the SV40 genome present in a line of transformed mouse cells Proceedings of the National Academy of Sciences of the United States of America. 71: 4183-4187. PMID 4372611 DOI: 10.1073/Pnas.71.10.4183  0.734
1974 Botchan M, McKenna G, Sharp PA. Cleavage of mouse DNA by a restriction enzyme as a clue to the arrangement of genes. Cold Spring Harbor Symposia On Quantitative Biology. 38: 383-95. PMID 4364785 DOI: 10.1101/SQB.1974.038.01.041  0.511
1974 Botchan M, Ozanne B, Sambrook J. Characterization of SV40 DNA rescued from transformed mouse cells Symposia On Quantitative Biology. 39: 95-99. PMID 169101 DOI: 10.1101/Sqb.1974.039.01.014  0.387
1974 Sambrook J, Botchan M, Gallimore P, Ozanne B, Pettersson U, Williams J, Sharp PA. Viral DNA sequences in cells transformed by simian virus 40, adenovirus type 2 and adenovirus type 5 Symposia On Quantitative Biology. 39: 615-632. PMID 169095 DOI: 10.1101/Sqb.1974.039.01.075  0.503
1973 Hearst JE, Botchan M, Kram R, Beals E. The use of buoyant density profiles in determining the length and spacing of repeated sequences in DNA. Biochimica Et Biophysica Acta. 294: 173-83. PMID 4197075 DOI: 10.1016/0005-2787(73)90290-6  0.62
1973 Hearst JE, Botchan M. Deoxyribonucleic acid renaturation kinetics and hybridization. Probe to the structure of the eukaryotic chromosome Accounts of Chemical Research. 6: 293-298. DOI: 10.1021/Ar50069A002  0.455
1972 Carroll D, Botchan MR. Competition between pentalysine and actinomycin D for binding to DNA. Biochemical and Biophysical Research Communications. 46: 1661-7. PMID 5062742 DOI: 10.1016/0006-291X(72)90803-0  0.413
1972 Kram R, Botchan M, Hearst JE. Arrangement of the highly reiterated DNA sequences in the centric heterochromatin of Drosophila melanogaster. Evidence for interspersed spacer DNA. Journal of Molecular Biology. 64: 103-17. PMID 4622629 DOI: 10.1016/0022-2836(72)90323-3  0.621
1972 Carroll D, Botchan MR. Competition between pentalysine and actinomycin D for binding to DNA Biochemical and Biophysical Research Communications. 46: 1681-1687. DOI: 10.1016/0006-291X(72)90803-0  0.305
1971 Botchan M, Kram R, Schmid CW, Hearst JE. Isolation and chromosomal localization of highly repeated DNA sequences in Drosophila melanogaster. Proceedings of the National Academy of Sciences of the United States of America. 68: 1125-9. PMID 5001499 DOI: 10.1073/Pnas.68.6.1125  0.756
1971 Hearst JE, Botchan M. The eukaryotic chromosome. Annual Review of Biochemistry. 39: 151-82. PMID 4920819 DOI: 10.1146/Annurev.Bi.39.070170.001055  0.46
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