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Jonathan B. Cohen, Ph.D. - Publications

Affiliations: 
Massachusetts General Hospital, Boston, MA 
 1975-1982 Pharmacology Harvard Medical School, Boston, MA, United States 
 1982-1992 Anatomy and Neurobiology Washington University School of Medicine, St. Louis, MO, United States 
 1992- Neurobiology Harvard Medical School, Boston, MA, United States 
Area:
nicotinic acetylcholine receptors (AChR) and GABAa receptors
Website:
http://www.fas.harvard.edu/~biophys/Jonathan_B_Cohen.htm
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138 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DE. Competitive Antagonism of Etomidate Action by Diazepam. Anesthesiology. 133: 583-594. PMID 33370831 DOI: 10.1097/ALN.0000000000003403  0.324
2020 McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DE. Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies. Anesthesiology. PMID 32541553 DOI: 10.1097/Aln.0000000000003403  0.445
2020 Jayakar SS, Chiara DC, Zhou X, Wu B, Bruzik KS, Miller KW, Cohen JB. Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABA) receptors. The Journal of Biological Chemistry. PMID 32540960 DOI: 10.1074/Jbc.Ra120.013452  0.439
2020 Shalabi AR, Yu Z, Zhou X, Jounaidi Y, Chen H, Dai J, Kent DE, Feng HJ, Forman SA, Cohen JB, Bruzik KS, Miller KW. A potent photoreactive general anesthetic with novel binding site selectivity for GABA receptors. European Journal of Medicinal Chemistry. 194: 112261. PMID 32247113 DOI: 10.1016/J.Ejmech.2020.112261  0.378
2019 Yu Z, Chiara DC, Savechenkov PY, Bruzik KS, Cohen JB. A photoreactive analog of allopregnanolone enables identification of steroid-binding sites in a nicotinic acetylcholine receptor. The Journal of Biological Chemistry. PMID 30923128 DOI: 10.1074/Jbc.Ra118.007172  0.487
2019 Yu Z, Savechenkov PY, Bruzik KS, Cohen JB. Identifying Steroid Binding Sites in a Nicotinic Acetylcholine Receptor (nAChR) with a Photoreactive Analog of Alphaxalone Biophysical Journal. 116: 395a. DOI: 10.1016/J.Bpj.2018.11.2135  0.465
2019 Chiara DC, Wu B, Zhou X, Jayakar SS, Titterton K, Forman SA, Miller KW, Bruzik KS, Cohen JB. Identification of a High-Affinity Neurosteroid Binding Site in Human Alpha1Beta3 GabaAR using a Photoreactive Thdoc Analog Biophysical Journal. 116: 392a. DOI: 10.1016/J.Bpj.2018.11.2123  0.356
2019 Jayakar SS, Zhou X, Wu B, Miller KW, Bruzik KS, Cohen JB. Pharmacological Selectivity of a Steroid Binding Site at the Beta+-Alpha− Interface of Alpha1 Beta3 Gaba-A Receptors Biophysical Journal. 116: 392a. DOI: 10.1016/J.Bpj.2018.11.2122  0.372
2018 Wu B, Jayakar SS, Zhou X, Titterton K, Chiara DC, Szabo AL, Savechenkov PY, Kent DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors. European Journal of Medicinal Chemistry. 162: 810-824. PMID 30544077 DOI: 10.1016/J.Ejmech.2018.11.019  0.444
2018 McGrath M, Yu Z, Jayakar SS, Ma C, Tolia M, Zhou X, Miller KW, Cohen JB, Raines DE. Etomidate and Etomidate Analog Binding and Positive Modulation of γ-Aminobutyric Acid Type A Receptors: Evidence for a State-dependent Cutoff Effect. Anesthesiology. PMID 30052529 DOI: 10.1097/Aln.0000000000002356  0.39
2017 Yu Z, Cohen JB. Enantiomeric barbiturates bind distinct inter- and intra-subunit binding sites in a nicotinic acetylcholine receptor (nAChR). The Journal of Biological Chemistry. PMID 28878016 DOI: 10.1074/Jbc.M117.808592  0.466
2017 Ma C, Pejo E, McGrath M, Jayakar SS, Zhou X, Miller KW, Cohen JB, Raines DE. Competitive Antagonism of Anesthetic Action at the γ-Aminobutyric Acid Type A Receptor by a Novel Etomidate Analog with Low Intrinsic Efficacy. Anesthesiology. PMID 28857763 DOI: 10.1097/Aln.0000000000001840  0.353
2017 Savechenkov PY, Chiara DC, Desai R, Stern AT, Zhou X, Ziemba AM, Szabo AL, Zhang Y, Cohen JB, Forman SA, Miller KW, Bruzik KS. Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands. European Journal of Medicinal Chemistry. 136: 334-347. PMID 28505538 DOI: 10.1016/J.Ejmech.2017.04.043  0.44
2017 Ang G, Deba F, Pandhare A, Blanton MP, Cohen JB, Hamouda AK. Photoaffinity Labeling of A4B2 Nicotinic Acetylcholine Receptor using [ 3 H]-Labeled Positive Allosteric Modulators Biophysical Journal. 112: 320a. DOI: 10.1016/J.Bpj.2016.11.1736  0.451
2016 Chiara DC, Jounaidi Y, Zhou X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type-A Receptors (GABAAR). The Journal of Biological Chemistry. PMID 27821594 DOI: 10.1074/Jbc.M116.753335  0.445
2016 Hamouda AK, Deba F, Wang ZJ, Cohen JB. Photolabeling a Nicotinic Acetylcholine Receptor (nAChR) with an (α4)3(β2)2 nAChR-selective Positive Allosteric Modulator. Molecular Pharmacology. PMID 26976945 DOI: 10.1124/Mol.116.103341  0.419
2016 Chiara DC, Savechenkov PY, Zhou X, Desai R, Stern AT, Zhang Y, Forman SA, Bruzik KS, Miller KW, Cohen JB. Interactions of a Photoreactive Steroid Anesthetic (F4N3-Alphaxalone) with Human α1β3γ2 GABA-A Receptors Biophysical Journal. 110: 455a. DOI: 10.1016/J.Bpj.2015.11.2438  0.456
2016 Jayakar SS, Zhou X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. Identifying GABA-A Receptor Modulators that Bind to Intersubunit Sites in the GABA-A Receptor Transmembrane Domain Biophysical Journal. 110: 454a-455a. DOI: 10.1016/J.Bpj.2015.11.2437  0.41
2015 Jayakar SS, Zhou X, Savechenkov PY, Chiara DC, Desai R, Bruzik KS, Miller KW, Cohen JB. Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface. The Journal of Biological Chemistry. PMID 26229099 DOI: 10.1074/Jbc.M115.672006  0.435
2015 Hamouda AK, Wang ZJ, Stewart DS, Jain AD, Glennon RA, Cohen JB. Desformylflustrabromine (dFBr) and [3H]dFBr-Labeled Binding Sites in a Nicotinic Acetylcholine Receptor. Molecular Pharmacology. 88: 1-11. PMID 25870334 DOI: 10.1124/Mol.115.098913  0.475
2014 Jayakar SS, Zhou X, Chiara DC, Dostalova Z, Savechenkov PY, Bruzik KS, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB. Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog. The Journal of Biological Chemistry. 289: 27456-68. PMID 25086038 DOI: 10.1074/Jbc.M114.581728  0.434
2014 Hamouda AK, Stewart DS, Chiara DC, Savechenkov PY, Bruzik KS, Cohen JB. Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate. Molecular Pharmacology. 85: 735-46. PMID 24563544 DOI: 10.1124/Mol.113.090985  0.511
2014 Chiara DC, Gill JF, Chen Q, Tillman T, Dailey WP, Eckenhoff RG, Xu Y, Tang P, Cohen JB. Photoaffinity labeling the propofol binding site in GLIC. Biochemistry. 53: 135-42. PMID 24341978 DOI: 10.1021/Bi401492K  0.454
2014 Hamouda AK, Jayakar SS, Chiara DC, Cohen JB. Photoaffinity labeling of nicotinic receptors: diversity of drug binding sites! Journal of Molecular Neuroscience : Mn. 53: 480-6. PMID 24158732 DOI: 10.1007/S12031-013-0150-1  0.453
2013 Chiara DC, Jayakar SS, Zhou X, Zhang X, Savechenkov PY, Bruzik KS, Miller KW, Cohen JB. Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor. The Journal of Biological Chemistry. 288: 19343-57. PMID 23677991 DOI: 10.1074/Jbc.M113.479725  0.456
2013 Hamouda AK, Kimm T, Cohen JB. Physostigmine and galanthamine bind in the presence of agonist at the canonical and noncanonical subunit interfaces of a nicotinic acetylcholine receptor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 485-94. PMID 23303929 DOI: 10.1523/Jneurosci.3483-12.2013  0.504
2013 Jayakar SS, Dailey WP, Eckenhoff RG, Cohen JB. Identification of propofol binding sites in a nicotinic acetylcholine receptor with a photoreactive propofol analog. The Journal of Biological Chemistry. 288: 6178-89. PMID 23300078 DOI: 10.1074/Jbc.M112.435909  0.477
2013 Jayakar SS, Zhou X, Dostalova Z, Dailey WP, Miller KW, Eckenhoff RG, Cohen JB. Identifying the Propofol Binding Site(S) in Heterologously Expressed Human Alpha1 Beta3 Gaba-A Receptors using a Photoreactive Propofol Analog Biophysical Journal. 104: 637a. DOI: 10.1016/J.Bpj.2012.11.3519  0.423
2012 Savechenkov PY, Zhang X, Chiara DC, Stewart DS, Ge R, Zhou X, Raines DE, Cohen JB, Forman SA, Miller KW, Bruzik KS. Allyl m-trifluoromethyldiazirine mephobarbital: an unusually potent enantioselective and photoreactive barbiturate general anesthetic. Journal of Medicinal Chemistry. 55: 6554-65. PMID 22734650 DOI: 10.1021/Jm300631E  0.396
2012 Pandhare A, Hamouda AK, Staggs B, Aggarwal S, Duddempudi PK, Lever JR, Lapinsky DJ, Jansen M, Cohen JB, Blanton MP. Bupropion binds to two sites in the Torpedo nicotinic acetylcholine receptor transmembrane domain: a photoaffinity labeling study with the bupropion analogue [(125)I]-SADU-3-72. Biochemistry. 51: 2425-35. PMID 22394379 DOI: 10.1021/Bi300101R  0.429
2012 Chiara DC, Dostalova Z, Jayakar SS, Zhou X, Miller KW, Cohen JB. Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue. Biochemistry. 51: 836-47. PMID 22243422 DOI: 10.1021/Bi201772M  0.415
2012 Pandhare A, Hamouda AK, Staggs B, Duddempudi PK, Lever JR, Cohen JB, Lapinsky DJ, Jansen M, Blanton MP. Bupropion Binds in the Middle (M2-9) of the Torpedo Nicotinic Acetylcholine Receptor Ion Channel Biophysical Journal. 102: 118a. DOI: 10.1016/J.Bpj.2011.11.661  0.444
2011 Stewart DS, Savechenkov PY, Dostalova Z, Chiara DC, Ge R, Raines DE, Cohen JB, Forman SA, Bruzik KS, Miller KW. p-(4-Azipentyl)propofol: a potent photoreactive general anesthetic derivative of propofol. Journal of Medicinal Chemistry. 54: 8124-35. PMID 22029276 DOI: 10.1021/Jm200943F  0.411
2011 Hamouda AK, Stewart DS, Husain SS, Cohen JB. Multiple transmembrane binding sites for p-trifluoromethyldiazirinyl-etomidate, a photoreactive Torpedo nicotinic acetylcholine receptor allosteric inhibitor. The Journal of Biological Chemistry. 286: 20466-77. PMID 21498509 DOI: 10.1074/Jbc.M111.219071  0.491
2011 Chiara DC, Yamodo IH, Miller KW, Cohen JB. Structural Differences in the Nicotinic Acetylcholine Receptor (NACHR) ion Channel Between Open and Desensitized States Revealed by Time-Resolved Photolabeling with [3H]Chlorpromazine (CPZ) Biophysical Journal. 100: 275a. DOI: 10.1016/J.Bpj.2010.12.1709  0.341
2011 Jayakar∗ SS, Dostalova Z, Chiara DC, Zhou X, Liu A, Miller KW, Cohen JB. Identifying an Etomidate Binding Site in Heterologously Expressed Human Alpha1/Beta3 GABAA Receptors (GABAAR) Using Photoactive Etomidate Analogs Biophysical Journal. 100: 271a. DOI: 10.1016/J.Bpj.2010.12.1689  0.43
2010 Husain SS, Stewart D, Desai R, Hamouda AK, Li SG, Kelly E, Dostalova Z, Zhou X, Cotten JF, Raines DE, Olsen RW, Cohen JB, Forman SA, Miller KW. p-Trifluoromethyldiazirinyl-etomidate: a potent photoreactive general anesthetic derivative of etomidate that is selective for ligand-gated cationic ion channels. Journal of Medicinal Chemistry. 53: 6432-44. PMID 20704351 DOI: 10.1021/Jm100498U  0.611
2010 Dakof GA, Cohen JB, Henderson CE, Duarte E, Boustani M, Blackburn A, Venzer E, Hawes S. A randomized pilot study of the Engaging Moms Program for family drug court. Journal of Substance Abuse Treatment. 38: 263-74. PMID 20116961 DOI: 10.1016/j.jsat.2010.01.002  0.372
2010 Li GD, Chiara DC, Cohen JB, Olsen RW. Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors. The Journal of Biological Chemistry. 285: 8615-20. PMID 20083606 DOI: 10.1074/Jbc.M109.074708  0.611
2010 Yamodo IH, Chiara DC, Cohen JB, Miller KW. Conformational changes in the nicotinic acetylcholine receptor during gating and desensitization. Biochemistry. 49: 156-65. PMID 19961216 DOI: 10.1021/Bi901550P  0.371
2010 Hamouda AK, Stewart D, Husain SS, Cohen JB. A Transmembrane Binding Site at a Subunit Interface for Torpedo Nicotinic Acetylcholine Receptor Potentiators And Inhibitors Biophysical Journal. 98: 131a. DOI: 10.1016/J.Bpj.2009.12.708  0.468
2010 Srivastava S, Hamouda AK, Talley TT, Pandhare A, Duddempudi PK, Hsiao H, Taylor P, Cohen JB, Blanton MP. Photoaffinity Labeling the Agonist Binding Sites of Torpedo and α4β2 Nicotinic Acetylcholine Receptors and Acetylcholine Binding Proteins (AChBPs) with [3H]Cytisine Biophysical Journal. 98: 130a-131a. DOI: 10.1016/J.Bpj.2009.12.706  0.481
2010 Chiara DC, Dostalova Z, Liu A, Zhou X, Forman SA, Miller KW, Cohen JB. Characterization of the Etomidate Binding Site in Expressed α1β3 GABAAR by Photoaffinity Labeling Biophysical Journal. 98: 704a. DOI: 10.1016/J.Bpj.2009.12.3862  0.456
2009 Chiara DC, Hamouda AK, Ziebell MR, Mejia LA, Garcia G, Cohen JB. [(3)H]chlorpromazine photolabeling of the torpedo nicotinic acetylcholine receptor identifies two state-dependent binding sites in the ion channel. Biochemistry. 48: 10066-77. PMID 19754159 DOI: 10.1021/Bi901271W  0.446
2009 Sanghvi M, Hamouda AK, Davis MI, Morton RA, Srivastava S, Pandhare A, Duddempudi PK, Machu TK, Lovinger DM, Cohen JB, Blanton MP. Hydrophobic photolabeling studies identify the lipid-protein interface of the 5-HT3A receptor. Biochemistry. 48: 9278-86. PMID 19715355 DOI: 10.1021/Bi901208J  0.342
2009 Srivastava S, Hamouda AK, Pandhare A, Duddempudi PK, Sanghvi M, Cohen JB, Blanton MP. [(3)H]Epibatidine photolabels non-equivalent amino acids in the agonist binding site of Torpedo and alpha4beta2 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 284: 24939-47. PMID 19620239 DOI: 10.1074/Jbc.M109.019083  0.494
2009 Li GD, Chiara DC, Cohen JB, Olsen RW. Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors. The Journal of Biological Chemistry. 284: 11771-5. PMID 19282280 DOI: 10.1074/Jbc.C900016200  0.602
2009 Chiara DC, Hong FH, Arevalo E, Husain SS, Miller KW, Forman SA, Cohen JB. Time-resolved photolabeling of the nicotinic acetylcholine receptor by [3H]azietomidate, an open-state inhibitor. Molecular Pharmacology. 75: 1084-95. PMID 19218367 DOI: 10.1124/Mol.108.054353  0.773
2009 Hamouda AK, Husain SS, Blanton MP, Cohen JB. Examining the Structure of the Neuronal a4b2 nAChR Transmembrane Domain by Photoaffinity Labeling Biophysical Journal. 96: 167a-168a. DOI: 10.1016/J.Bpj.2008.12.775  0.407
2009 Srivastava S, Hamouda AK, Sanghvi M, Pandhare A, Duddempudi PK, Hiyari S, Chiara DC, Cohen JB, Blanton MP. Photoaffinity Labeling the Agonist Binding Sites of nAChRs with [3H]Epibatidine Biophysical Journal. 96: 167a. DOI: 10.1016/J.Bpj.2008.12.773  0.431
2008 Hamouda AK, Chiara DC, Blanton MP, Cohen JB. Probing the structure of the affinity-purified and lipid-reconstituted torpedo nicotinic acetylcholine receptor. Biochemistry. 47: 12787-94. PMID 18991407 DOI: 10.1021/Bi801476J  0.421
2008 Nirthanan S, Garcia G, Chiara DC, Husain SS, Cohen JB. Identification of binding sites in the nicotinic acetylcholine receptor for TDBzl-etomidate, a photoreactive positive allosteric effector. The Journal of Biological Chemistry. 283: 22051-62. PMID 18524766 DOI: 10.1074/Jbc.M801332200  0.508
2007 Hamouda AK, Sanghvi M, Chiara DC, Cohen JB, Blanton MP. Identifying the lipid-protein interface of the alpha4beta2 neuronal nicotinic acetylcholine receptor: hydrophobic photolabeling studies with 3-(trifluoromethyl)-3-(m-[125I]iodophenyl)diazirine. Biochemistry. 46: 13837-46. PMID 17994769 DOI: 10.1021/Bi701705R  0.406
2007 Garcia G, Chiara DC, Nirthanan S, Hamouda AK, Stewart DS, Cohen JB. [3H]Benzophenone photolabeling identifies state-dependent changes in nicotinic acetylcholine receptor structure. Biochemistry. 46: 10296-307. PMID 17685589 DOI: 10.1021/Bi7008163  0.504
2006 Li GD, Chiara DC, Sawyer GW, Husain SS, Olsen RW, Cohen JB. Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11599-605. PMID 17093081 DOI: 10.1523/Jneurosci.3467-06.2006  0.63
2006 Stewart DS, Chiara DC, Cohen JB. Mapping the structural requirements for nicotinic acetylcholine receptor activation by using tethered alkyltrimethylammonium agonists and antagonists. Biochemistry. 45: 10641-53. PMID 16939216 DOI: 10.1021/Bi060686T  0.437
2006 Husain SS, Nirthanan S, Ruesch D, Solt K, Cheng Q, Li GD, Arevalo E, Olsen RW, Raines DE, Forman SA, Cohen JB, Miller KW. Synthesis of trifluoromethylaryl diazirine and benzophenone derivatives of etomidate that are potent general anesthetics and effective photolabels for probing sites on ligand-gated ion channels. Journal of Medicinal Chemistry. 49: 4818-25. PMID 16884293 DOI: 10.1021/Jm051207B  0.627
2006 Kasheverov IE, Chiara DC, Zhmak MN, Maslennikov IV, Pashkov VS, Arseniev AS, Utkin YN, Cohen JB, Tsetlin VI. alpha-Conotoxin GI benzoylphenylalanine derivatives. (1)H-NMR structures and photoaffinity labeling of the Torpedo californica nicotinic acetylcholine receptor. The Febs Journal. 273: 1373-88. PMID 16689926 DOI: 10.1111/J.1742-4658.2006.05161.X  0.494
2006 Hamouda AK, Chiara DC, Sauls D, Cohen JB, Blanton MP. Cholesterol interacts with transmembrane alpha-helices M1, M3, and M4 of the Torpedo nicotinic acetylcholine receptor: photolabeling studies using [3H]Azicholesterol. Biochemistry. 45: 976-86. PMID 16411773 DOI: 10.1021/Bi051978H  0.412
2006 Andreeva IE, Nirthanan S, Cohen JB, Pedersen SE. Site specificity of agonist-induced opening and desensitization of the Torpedo californica nicotinic acetylcholine receptor. Biochemistry. 45: 195-204. PMID 16388595 DOI: 10.1021/Bi0516024  0.685
2005 Bianchetta MJ, Betensky RA, Cohen JB. Cell-surface MuSK self-association: a crucial role for the putative signal sequence. Biochemistry. 44: 16229-38. PMID 16331983 DOI: 10.1021/Bi051549J  0.746
2005 Nirthanan S, Ziebell MR, Chiara DC, Hong F, Cohen JB. Photolabeling the Torpedo nicotinic acetylcholine receptor with 4-azido-2,3,5,6-tetrafluorobenzoylcholine, a partial agonist. Biochemistry. 44: 13447-56. PMID 16216068 DOI: 10.1021/Bi051209Y  0.799
2005 Arevalo E, Chiara DC, Forman SA, Cohen JB, Miller KW. Gating-enhanced accessibility of hydrophobic sites within the transmembrane region of the nicotinic acetylcholine receptor's {delta}-subunit. A time-resolved photolabeling study. The Journal of Biological Chemistry. 280: 13631-40. PMID 15664985 DOI: 10.1074/Jbc.M413911200  0.415
2004 Trinidad JC, Cohen JB. Neuregulin inhibits acetylcholine receptor aggregation in myotubes. The Journal of Biological Chemistry. 279: 31622-8. PMID 15155732 DOI: 10.1074/Jbc.M400044200  0.635
2004 Ziebell MR, Nirthanan S, Husain SS, Miller KW, Cohen JB. Identification of binding sites in the nicotinic acetylcholine receptor for [3H]azietomidate, a photoactivatable general anesthetic. The Journal of Biological Chemistry. 279: 17640-9. PMID 14761946 DOI: 10.1074/Jbc.M313886200  0.492
2003 Chiara DC, Dangott LJ, Eckenhoff RG, Cohen JB. Identification of nicotinic acetylcholine receptor amino acids photolabeled by the volatile anesthetic halothane. Biochemistry. 42: 13457-67. PMID 14621991 DOI: 10.1021/Bi0351561  0.488
2003 Husain SS, Ziebell MR, Ruesch D, Hong F, Arevalo E, Kosterlitz JA, Olsen RW, Forman SA, Cohen JB, Miller KW. 2-(3-Methyl-3H-diaziren-3-yl)ethyl 1-(1-phenylethyl)-1H-imidazole-5-carboxylate: a derivative of the stereoselective general anesthetic etomidate for photolabeling ligand-gated ion channels. Journal of Medicinal Chemistry. 46: 1257-65. PMID 12646036 DOI: 10.1021/Jm020465V  0.794
2003 Chiara DC, Trinidad JC, Wang D, Ziebell MR, Sullivan D, Cohen JB. Identification of amino acids in the nicotinic acetylcholine receptor agonist binding site and ion channel photolabeled by 4-[(3-trifluoromethyl)-3H-diazirin-3-yl]benzoylcholine, a novel photoaffinity antagonist. Biochemistry. 42: 271-83. PMID 12525154 DOI: 10.1021/Bi0269815  0.734
2002 Sawyer GW, Chiara DC, Olsen RW, Cohen JB. Identification of the bovine gamma-aminobutyric acid type A receptor alpha subunit residues photolabeled by the imidazobenzodiazepine [3H]Ro15-4513. The Journal of Biological Chemistry. 277: 50036-45. PMID 12388542 DOI: 10.1074/Jbc.M209281200  0.642
2002 Sullivan D, Chiara DC, Cohen JB. Mapping the agonist binding site of the nicotinic acetylcholine receptor by cysteine scanning mutagenesis: antagonist footprint and secondary structure prediction. Molecular Pharmacology. 61: 463-72. PMID 11809872 DOI: 10.1124/Mol.61.2.463  0.447
2001 Blanton MP, Lala AK, Cohen JB. Identification and characterization of membrane-associated polypeptides in Torpedo nicotinic acetylcholine receptor-rich membranes by hydrophobic photolabeling. Biochimica Et Biophysica Acta. 1512: 215-24. PMID 11406098 DOI: 10.1016/S0005-2736(01)00321-2  0.455
2001 Gallagher MJ, Chiara DC, Cohen JB. Interactions between 3-(Trifluoromethyl)-3-(m-[(125)I]iodophenyl)diazirine and tetracaine, phencyclidine, or histrionicotoxin in the Torpedo series nicotinic acetylcholine receptor ion channel. Molecular Pharmacology. 59: 1514-22. PMID 11353813 DOI: 10.1124/Mol.59.6.1514  0.423
2001 Bartoli M, Ramarao MK, Cohen JB. Interactions of the rapsyn RING-H2 domain with dystroglycan. The Journal of Biological Chemistry. 276: 24911-7. PMID 11342559 DOI: 10.1074/Jbc.M103258200  0.579
2001 Chiara DC, Kloczewiak MA, Addona GH, Yu JA, Cohen JB, Miller KW. Site of resting state inhibition of the nicotinic acetylcholine receptor by a hydrophobic inhibitor. Biochemistry. 40: 296-304. PMID 11141083 DOI: 10.1021/Bi0021481  0.416
2001 Ramarao MK, Bianchetta MJ, Lanken J, Cohen JB. Role of rapsyn tetratricopeptide repeat and coiled-coil domains in self-association and nicotinic acetylcholine receptor clustering. The Journal of Biological Chemistry. 276: 7475-83. PMID 11087759 DOI: 10.1074/Jbc.M009888200  0.75
2001 Xie Y, Cohen JB. Contributions of Torpedo nicotinic acetylcholine receptor gamma Trp-55 and delta Trp-57 to agonist and competitive antagonist function. The Journal of Biological Chemistry. 276: 2417-26. PMID 11056174 DOI: 10.1074/Jbc.M009085200  0.487
2000 Trinidad JC, Fischbach GD, Cohen JB. The Agrin/MuSK signaling pathway is spatially segregated from the neuregulin/ErbB receptor signaling pathway at the neuromuscular junction. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 8762-70. PMID 11102484 DOI: 10.1523/Jneurosci.20-23-08762.2000  0.635
2000 Pratt MB, Pedersen SE, Cohen JB. Identification of the sites of incorporation of [3H]ethidium diazide within the Torpedo nicotinic acetylcholine receptor ion channel. Biochemistry. 39: 11452-62. PMID 10985791 DOI: 10.1021/Bi0011680  0.709
2000 Wang D, Chiara DC, Xie Y, Cohen JB. Probing the structure of the nicotinic acetylcholine receptor with 4-benzoylbenzoylcholine, a novel photoaffinity competitive antagonist. The Journal of Biological Chemistry. 275: 28666-74. PMID 10893246 DOI: 10.1074/Jbc.M005441200  0.513
2000 Pratt MB, Husain SS, Miller KW, Cohen JB. Identification of sites of incorporation in the nicotinic acetylcholine receptor of a photoactivatible general anesthetic. The Journal of Biological Chemistry. 275: 29441-51. PMID 10859324 DOI: 10.1074/Jbc.M004710200  0.459
2000 Sullivan DA, Cohen JB. Mapping the agonist binding site of the nicotinic acetylcholine receptor. Orientation requirements for activation by covalent agonist. The Journal of Biological Chemistry. 275: 12651-60. PMID 10777557 DOI: 10.1074/Jbc.275.17.12651  0.474
1999 Husain SS, Forman SA, Kloczewiak MA, Addona GH, Olsen RW, Pratt MB, Cohen JB, Miller KW. Synthesis and properties of 3-(2-hydroxyethyl)-3-n-pentyldiazirine, a photoactivable general anesthetic. Journal of Medicinal Chemistry. 42: 3300-7. PMID 10464016 DOI: 10.1021/Jm9806300  0.632
1999 Gallagher MJ, Cohen JB. Identification of amino acids of the torpedo nicotinic acetylcholine receptor contributing to the binding site for the noncompetitive antagonist [(3)H]tetracaine. Molecular Pharmacology. 56: 300-7. PMID 10419548 DOI: 10.1124/Mol.56.2.300  0.509
1999 Middleton RE, Strnad NP, Cohen JB. Photoaffinity labeling the torpedo nicotinic acetylcholine receptor with [(3)H]tetracaine, a nondesensitizing noncompetitive antagonist. Molecular Pharmacology. 56: 290-9. PMID 10419547 DOI: 10.1124/Mol.56.2.290  0.491
1999 Chiara DC, Xie Y, Cohen JB. Structure of the agonist-binding sites of the Torpedo nicotinic acetylcholine receptor: affinity-labeling and mutational analyses identify gamma Tyr-111/delta Arg-113 as antagonist affinity determinants. Biochemistry. 38: 6689-98. PMID 10350488 DOI: 10.1021/Bi9901735  0.498
1999 Blanton MP, Xie Y, Dangott LJ, Cohen JB. The steroid promegestone is a noncompetitive antagonist of the Torpedo nicotinic acetylcholine receptor that interacts with the lipid-protein interface. Molecular Pharmacology. 55: 269-78. PMID 9927618 DOI: 10.1124/Mol.55.2.269  0.479
1998 Lugovskoy AA, Maslennikov IV, Utkin YN, Tsetlin VI, Cohen JB, Arseniev AS. Spatial structure of the M3 transmembrane segment of the nicotinic acetylcholine receptor alpha subunit. European Journal of Biochemistry / Febs. 255: 455-61. PMID 9716388 DOI: 10.1046/J.1432-1327.1998.2550455.X  0.411
1998 Blanton MP, Dangott LJ, Raja SK, Lala AK, Cohen JB. Probing the structure of the nicotinic acetylcholine receptor ion channel with the uncharged photoactivable compound -3H-diazofluorene. The Journal of Biological Chemistry. 273: 8659-68. PMID 9535841 DOI: 10.1074/Jbc.273.15.8659  0.441
1998 Ramarao MK, Cohen JB. Mechanism of nicotinic acetylcholine receptor cluster formation by rapsyn. Proceedings of the National Academy of Sciences of the United States of America. 95: 4007-12. PMID 9520483 DOI: 10.1073/Pnas.95.7.4007  0.425
1998 Chiara DC, Middleton RE, Cohen JB. Identification of tryptophan 55 as the primary site of [3H]nicotine photoincorporation in the gamma-subunit of the Torpedo nicotinic acetylcholine receptor. Febs Letters. 423: 223-6. PMID 9512361 DOI: 10.1016/S0014-5793(98)00093-3  0.501
1998 Miller KW, Addona GH, Cohen JB, Forman SA, Husain SS, Kloczewiak MA, Olsen RW. PROBING ANESTHETIC SITES OF ACTION WITH A NOVEL GENERAL ANESTHETIC; 3,3-AZI-OCTAN-1-OL Anesthesiology. 89: 732A. DOI: 10.1097/00000542-199809130-00038  0.512
1997 Chiara DC, Cohen JB. Identification of amino acids contributing to high and low affinity d-tubocurarine sites in the Torpedo nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 272: 32940-50. PMID 9407073 DOI: 10.1074/Jbc.272.52.32940  0.501
1996 Sadoulet-Puccio HM, Khurana TS, Cohen JB, Kunkel LM. Cloning and characterization of the human homologue of a dystrophin related phosphoprotein found at the Torpedo electric organ post-synaptic membrane. Human Molecular Genetics. 5: 489-96. PMID 8845841 DOI: 10.1093/Hmg/5.4.489  0.311
1995 Froehner SC, Huganir RL, Cohen JB, Changeux J. John Paul Merlie (1945–1995) Neuron. 15: 21. DOI: 10.1016/0896-6273(95)90060-8  0.36
1994 Blanton MP, Cohen JB. Identifying the lipid-protein interface of the Torpedo nicotinic acetylcholine receptor: secondary structure implications. Biochemistry. 33: 2859-72. PMID 8130199 DOI: 10.1021/Bi00176A016  0.366
1994 Salih E, Chishti SB, Vicedomine P, Cohen SG, Chiara DC, Cohen JB. Active-site peptides of acetylcholinesterase of Electrophorus electricus: labelling of His-440 by 1-bromo-[2-14C]pinacolone and Ser-200 by tritiated diisopropyl fluorophosphate. Biochimica Et Biophysica Acta. 1208: 324-31. PMID 7947965 DOI: 10.1016/0167-4838(94)90120-1  0.324
1994 Blanton MP, Li YM, Stimson ER, Maggio JE, Cohen JB. Agonist-induced photoincorporation of a p-benzoylphenylalanine derivative of substance P into membrane-spanning region 2 of the Torpedo nicotinic acetylcholine receptor delta subunit. Molecular Pharmacology. 46: 1048-55. PMID 7528876  0.317
1993 Wagner KR, Cohen JB, Huganir RL. The 87K postsynaptic membrane protein from Torpedo is a protein-tyrosine kinase substrate homologous to dystrophin. Neuron. 10: 511-22. PMID 8461138 DOI: 10.1016/0896-6273(93)90338-R  0.344
1992 Pedersen SE, Sharp SD, Liu WS, Cohen JB. Structure of the noncompetitive antagonist-binding site of the Torpedo nicotinic acetylcholine receptor. [3H]meproadifen mustard reacts selectively with alpha-subunit Glu-262. The Journal of Biological Chemistry. 267: 10489-99. PMID 1587830  0.676
1992 Blanton MP, Cohen JB. Mapping the lipid-exposed regions in the Torpedo californica nicotinic acetylcholine receptor. Biochemistry. 31: 3738-50. PMID 1567828 DOI: 10.1021/Bi00130A003  0.415
1992 Blanton MP, Cohen JB. Mapping the lipid-exposed regions in the Torpedo californica nicotinic acetylcholine receptor. [Erratum to document cited in CA116(19):188175b] Biochemistry. 31: 5951-5951. DOI: 10.1021/Bi00140A035  0.327
1991 Middleton RE, Cohen JB. Mapping of the acetylcholine binding site of the nicotinic acetylcholine receptor: [3H]nicotine as an agonist photoaffinity label. Biochemistry. 30: 6987-97. PMID 2069955 DOI: 10.1021/Bi00242A026  0.5
1991 Cohen SG, Chishti SB, Bell DA, Howard SI, Salih E, Cohen JB. General occurrence of binding to acetylcholinesterase-substrate complex in noncompetitive inhibition and in inhibition by substrate. Biochimica Et Biophysica Acta. 1076: 112-22. PMID 1986784 DOI: 10.1016/0167-4838(91)90227-Q  0.312
1991 White BH, Howard S, Cohen SG, Cohen JB. The hydrophobic photoreagent 3-(trifluoromethyl)-3-m-([125I] iodophenyl) diazirine is a novel noncompetitive antagonist of the nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 266: 21595-607. PMID 1939189  0.399
1991 Cohen JB, Sharp SD, Liu WS. Structure of the agonist-binding site of the nicotinic acetylcholine receptor. [3H]acetylcholine mustard identifies residues in the cation-binding subsite. The Journal of Biological Chemistry. 266: 23354-64. PMID 1744130  0.402
1990 Tsui HC, Cohen JB, Fischbach GD. Variation in the ratio of acetylcholine receptors and the Mr 43,000 receptor-associated protein in embryonic chick myotubes and myoblasts. Developmental Biology. 140: 437-46. PMID 2373261 DOI: 10.1016/0012-1606(90)90092-W  0.387
1990 Pedersen SE, Cohen JB. d-Tubocurarine binding sites are located at alpha-gamma and alpha-delta subunit interfaces of the nicotinic acetylcholine receptor. Proceedings of the National Academy of Sciences of the United States of America. 87: 2785-9. PMID 2320589 DOI: 10.1073/Pnas.87.7.2785  0.69
1990 Pedersen SE, Bridgman PC, Sharp SD, Cohen JB. Identification of a cytoplasmic region of the Torpedo nicotinic acetylcholine receptor alpha-subunit by epitope mapping. The Journal of Biological Chemistry. 265: 569-81. PMID 1688436  0.634
1989 Carr C, Tyler AN, Cohen JB. Myristic acid is the NH2-terminal blocking group of the 43-kDa protein of Torpedo nicotinic post-synaptic membranes. Febs Letters. 243: 65-9. PMID 2920827 DOI: 10.1016/0014-5793(89)81219-0  0.323
1989 Carr C, Fischbach GD, Cohen JB. A novel 87,000-Mr protein associated with acetylcholine receptors in Torpedo electric organ and vertebrate skeletal muscle. The Journal of Cell Biology. 109: 1753-64. PMID 2793938 DOI: 10.1083/Jcb.109.4.1753  0.372
1988 Musil LS, Carr C, Cohen JB, Merlie JP. Acetylcholine receptor-associated 43K protein contains covalently bound myristate. The Journal of Cell Biology. 107: 1113-21. PMID 3417776 DOI: 10.1083/Jcb.107.3.1113  0.606
1988 White BH, Cohen JB. Photolabeling of membrane-bound Torpedo nicotinic acetylcholine receptor with the hydrophobic probe 3-trifluoromethyl-3-(m-[125I]iodophenyl)diazirine. Biochemistry. 27: 8741-51. PMID 3242605 DOI: 10.1021/Bi00424A009  0.451
1987 Frail DE, Mudd J, Shah V, Carr C, Cohen JB, Merlie JP. cDNAs for the postsynaptic 43-kDa protein of Torpedo electric organ encode two proteins with different carboxyl termini. Proceedings of the National Academy of Sciences of the United States of America. 84: 6302-6. PMID 3476945 DOI: 10.1073/Pnas.84.17.6302  0.594
1987 Carr C, McCourt D, Cohen JB. The 43-kilodalton protein of Torpedo nicotinic postsynaptic membranes: purification and determination of primary structure. Biochemistry. 26: 7090-102. PMID 3427060 DOI: 10.1021/Bi00396A034  0.348
1987 Bridgman PC, Carr C, Pedersen SE, Cohen JB. Visualization of the cytoplasmic surface of Torpedo postsynaptic membranes by freeze-etch and immunoelectron microscopy. The Journal of Cell Biology. 105: 1829-46. PMID 3312239 DOI: 10.1083/Jcb.105.4.1829  0.636
1987 Cohen SG, Bano Chishti S, Reese H, Howard SI, Solomon M, Cohen JB. Substituted benzenes and phenols as reversible inhibitors of acetylcholinesterase: Polar, trimethyl, and synergistic effects Bioorganic Chemistry. 15: 237-249. DOI: 10.1016/0045-2068(87)90022-8  0.316
1986 Dreyer EB, Hasan F, Cohen SG, Cohen JB. Reaction of [3H]meproadifen mustard with membrane-bound Torpedo acetylcholine receptor. The Journal of Biological Chemistry. 261: 13727-34. PMID 3759990  0.395
1986 Pedersen SE, Dreyer EB, Cohen JB. Location of ligand-binding sites on the nicotinic acetylcholine receptor alpha-subunit. The Journal of Biological Chemistry. 261: 13735-43. PMID 3093482  0.668
1984 Boyd ND, Cohen JB. Desensitization of membrane-bound Torpedo acetylcholine receptor by amine noncompetitive antagonists and aliphatic alcohols: studies of [3H]acetylcholine binding and 22Na+ ion fluxes. Biochemistry. 23: 4023-33. PMID 6091734 DOI: 10.1021/Bi00313A003  0.438
1982 Neubig RR, Boyd ND, Cohen JB. Conformations of Torpedo acetylcholine receptor associated with ion transport and desensitization. Biochemistry. 21: 3460-7. PMID 7115680 DOI: 10.1021/Bi00257A032  0.552
1982 St John PA, Froehner SC, Goodenough DA, Cohen JB. Nicotinic postsynaptic membranes from Torpedo: sidedness, permeability to macromolecules, and topography of major polypeptides. The Journal of Cell Biology. 92: 333-42. PMID 6174528 DOI: 10.1083/Jcb.92.2.333  0.366
1981 Froehner SC, Gulbrandsen V, Hyman C, Jeng AY, Neubig RR, Cohen JB. Immunofluorescence localization at the mammalian neuromuscular junction of the Mr 43,000 protein of Torpedo postsynaptic membranes. Proceedings of the National Academy of Sciences of the United States of America. 78: 5230-4. PMID 7029531 DOI: 10.1073/Pnas.78.8.5230  0.554
1981 Jeng AY, St. John PA, Cohen JB. Fractionation by velocity sedimentation of Torpedo nicotinic post-synaptic membranes Bba - Biomembranes. 646: 411-421. DOI: 10.1016/0005-2736(81)90310-2  0.348
1980 Boyd ND, Cohen JB. Kinetics of binding of [3H]acetylcholine to Torpedo postsynaptic membranes: association and dissociation rate constants by rapid mixing and ultrafiltration. Biochemistry. 19: 5353-8. PMID 7448174 DOI: 10.1021/Bi00564A032  0.448
1980 Boyd ND, Cohen JB. Kinetics of binding of [3H]acetylcholine and [3H]carbamoylcholine to Torpedo postsynaptic membranes: slow conformational transitions of the cholinergic receptor. Biochemistry. 19: 5344-53. PMID 7448173 DOI: 10.1021/Bi00564A031  0.442
1980 Neubig RR, Cohen JB. Permeability control by cholinergic receptors in Torpedo postsynaptic membranes: agonist dose-response relations measured at second and millisecond times. Biochemistry. 19: 2770-9. PMID 7397104 DOI: 10.1021/Bi00553A036  0.623
1980 Jeng AY, Cohen JB. Agonists of Torpedo nicotinic receptors: essential role of a positive charge. Annals of the New York Academy of Sciences. 358: 370-3. PMID 6938159 DOI: 10.1111/J.1749-6632.1980.Tb15425.X  0.368
1979 Neubig RR, Cohen JB. Equilibrium binding of [3H]tubocurarine and [3H]acetylcholine by Torpedo postsynaptic membranes: stoichiometry and ligand interactions. Biochemistry. 18: 5464-75. PMID 518850 DOI: 10.1021/Bi00591A032  0.616
1979 Neubig RR, Krodel EK, Boyd ND, Cohen JB. Acetylcholine and local anesthetic binding to Torpedo nicotinic postsynaptic membranes after removal of nonreceptor peptides. Proceedings of the National Academy of Sciences of the United States of America. 76: 690-4. PMID 34154 DOI: 10.1073/Pnas.76.2.690  0.607
1975 Cohen JB, Changeux JP. The cholinergic receptor protein in its membrane environment. Annual Review of Pharmacology. 15: 83-103. PMID 1096798 DOI: 10.1146/annurev.pa.15.040175.000503  0.458
1975 Brisson AD, Scandella CJ, Bienvenüe A, Devaux PF, Cohen JB, Changeux JP. Interaction of a spin-labeled long chain acylcholine with the cholinergic receptor protein in its membrane environment. Proceedings of the National Academy of Sciences of the United States of America. 72: 1087-91. PMID 165483  0.47
1974 Cohen JB, Weber M, Changeux JP. Effects of local anesthetics and calcium on the interaction of cholinergic ligands with the nicotinic receptor protein from Torpedo marmorata. Molecular Pharmacology. 10: 904-32. PMID 25771543  0.539
1974 Dupont Y, Cohen JB, Changeux JP. X-ray diffraction study of membrane fragments rich in acetylcholine receptor protein prepared from the electric organ of Torpedo marmorata. Febs Letters. 40: 130-3. PMID 4855432 DOI: 10.1016/0014-5793(74)80910-5  0.489
1974 Cohen JB, Weber M, Changeux JP. [Effect of local anesthetics on the binding properties of cholinergic receptors of the torpedo]. Comptes Rendus Hebdomadaires Des Sã©Ances De L'Acadã©Mie Des Sciences. Sã©Rie D: Sciences Naturelles. 278: 1269-72. PMID 4276961  0.492
1973 Cohen JB, Changeux JP. Interaction of a fluorescent ligand with membrane-bound cholinergic receptor from Torpedo marmorata. Biochemistry. 12: 4855-64. PMID 4761972 DOI: 10.1021/Bi00748A008  0.508
1973 Cohen JB, Changeux JP. [Interaction of a fluorescent ligand with the protein receptor of acetylcholine present in Torpedo marmorata membrane fragments]. Comptes Rendus Hebdomadaires Des Sã©Ances De L'Acadã©Mie Des Sciences. Sã©Rie D: Sciences Naturelles. 277: 603-6. PMID 4205999  0.458
1973 Cartaud J, Benedetti EL, Cohen JB, Meunier JC, Changeux JP. Presence of a lattice structure in membrane fragments rich in nicotinic receptor protein from the electric organ of Torpedo marmorata. Febs Letters. 33: 109-13. PMID 4124671 DOI: 10.1016/0014-5793(73)80171-1  0.54
1972 Cohen JB, Weber M, Huchet M, Changeux JP. Purification from Torpedo marmorata electric tissue of membrane fragments particularly rich in cholinergic receptor protein. Febs Letters. 26: 43-7. PMID 4636749 DOI: 10.1016/0014-5793(72)80538-6  0.541
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