| Year |
Citation |
Score |
| 2023 |
Dulin CC, Sharma P, Frigo L, Voehler MW, Iverson TM, Bachmann BO. EvdS6 is a bifunctional decarboxylase from the everninomicin gene cluster. The Journal of Biological Chemistry. 104893. PMID 37286037 DOI: 10.1016/j.jbc.2023.104893 |
0.336 |
|
| 2020 |
Limbrick EM, Ynigez-Gutierrez AE, Dulin CC, Derewacz DK, Spraggins JM, McCulloch KM, Iverson TM, Bachmann BO. Methyltransferase contingencies in the pathway of everninomicin D antibiotics and analogs. Chembiochem : a European Journal of Chemical Biology. PMID 32686210 DOI: 10.1002/Cbic.202000305 |
0.317 |
|
| 2019 |
Yñigez-Gutierrez AE, Bachmann BO. Fixing the Unfixable: The Art of Optimizing Natural Products for Human Medicine. Journal of Medicinal Chemistry. PMID 31026161 DOI: 10.1021/Acs.Jmedchem.9B00246 |
0.322 |
|
| 2018 |
Starbird CA, Perry NA, Chen Q, Berndt S, Yamakawa I, Loukachevitch LV, Limbrick EM, Bachmann BO, Iverson TM, McCulloch KM. The Structure of the Bifunctional Everninomicin Biosynthetic Enzyme EvdMO1 Suggests Independent Activity of the Fused Methyltransferase-Oxidase Domains. Biochemistry. PMID 30525509 DOI: 10.1021/acs.biochem.8b00836 |
0.364 |
|
| 2018 |
Covington BC, Spraggins JM, Ynigez-Gutierrez AE, Hylton ZB, Bachmann BO. Response of Hypogean Actinobacterial Genera Secondary Metabolism to Chemical and Biological Stimuli. Applied and Environmental Microbiology. PMID 30030223 DOI: 10.1128/Aem.01125-18 |
0.319 |
|
| 2016 |
Masuyer G, Cozier GE, Kramer GJ, Bachmann BO, Acharya KR. Crystal structure of a peptidyl-dipeptidase K-26-DCP from Actinomycete in complex with its natural inhibitor. The Febs Journal. PMID 27754586 DOI: 10.1111/Febs.13928 |
0.589 |
|
| 2016 |
Bachmann BO. Applied evolutionary theories for engineering of secondary metabolic pathways. Current Opinion in Chemical Biology. 35: 133-141. PMID 27736648 DOI: 10.1016/J.Cbpa.2016.09.021 |
0.332 |
|
| 2016 |
Covington BC, McLean JA, Bachmann BO. Comparative mass spectrometry-based metabolomics strategies for the investigation of microbial secondary metabolites. Natural Product Reports. PMID 27604382 DOI: 10.1039/C6Np00048G |
0.31 |
|
| 2016 |
Tianero MD, Pierce E, Raghuraman S, Sardar D, McIntosh JA, Heemstra JR, Schonrock Z, Covington BC, Maschek JA, Cox JE, Bachmann BO, Olivera BM, Ruffner DE, Schmidt EW. Metabolic model for diversity-generating biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26831074 DOI: 10.1073/Pnas.1525438113 |
0.555 |
|
| 2015 |
Sartor L, Ibarra C, Al-Mestarihi A, Bachmann BO, Vey JL. Structure of DnmZ, a nitrososynthase in the Streptomyces peucetius anthracycline biosynthetic pathway. Acta Crystallographica. Section F, Structural Biology Communications. 71: 1205-14. PMID 26457508 DOI: 10.1107/S2053230X15014272 |
0.796 |
|
| 2015 |
McCulloch KM, McCranie EK, Smith JA, Sarwar M, Mathieu JL, Gitschlag BL, Du Y, Bachmann BO, Iverson TM. Oxidative cyclizations in orthosomycin biosynthesis expand the known chemistry of an oxygenase superfamily. Proceedings of the National Academy of Sciences of the United States of America. 112: 11547-52. PMID 26240321 DOI: 10.1073/Pnas.1500964112 |
0.419 |
|
| 2015 |
Derewacz DK, Covington BC, McLean JA, Bachmann BO. Mapping Microbial Response Metabolomes for Induced Natural Product Discovery. Acs Chemical Biology. PMID 26039241 DOI: 10.1021/Acschembio.5B00001 |
0.306 |
|
| 2014 |
Kramer GJ, Mohd A, Schwager SL, Masuyer G, Acharya KR, Sturrock ED, Bachmann BO. Interkingdom pharmacology of Angiotensin-I converting enzyme inhibitor phosphonates produced by actinomycetes. Acs Medicinal Chemistry Letters. 5: 346-51. PMID 24900839 DOI: 10.1021/Ml4004588 |
0.599 |
|
| 2014 |
McCranie EK, Bachmann BO. Bioactive oligosaccharide natural products. Natural Product Reports. 31: 1026-42. PMID 24883430 DOI: 10.1039/C3Np70128J |
0.312 |
|
| 2014 |
Birmingham WR, Starbird CA, Panosian TD, Nannemann DP, Iverson TM, Bachmann BO. Bioretrosynthetic construction of a didanosine biosynthetic pathway. Nature Chemical Biology. 10: 392-9. PMID 24657930 DOI: 10.1038/Nchembio.1494 |
0.772 |
|
| 2013 |
Al-Mestarihi A, Romo A, Liu HW, Bachmann BO. Nitrososynthase-triggered oxidative carbon-carbon bond cleavage in baumycin biosynthesis. Journal of the American Chemical Society. 135: 11457-60. PMID 23885759 DOI: 10.1021/Ja404987R |
0.78 |
|
| 2013 |
Derewacz DK, Goodwin CR, McNees CR, McLean JA, Bachmann BO. Antimicrobial drug resistance affects broad changes in metabolomic phenotype in addition to secondary metabolism. Proceedings of the National Academy of Sciences of the United States of America. 110: 2336-41. PMID 23341601 DOI: 10.1073/Pnas.1218524110 |
0.311 |
|
| 2012 |
Iverson TM, Panosian TD, Birmingham WR, Nannemann DP, Bachmann BO. Molecular differences between a mutase and a phosphatase: investigations of the activation step in Bacillus cereus phosphopentomutase. Biochemistry. 51: 1964-75. PMID 22329805 DOI: 10.1021/Bi201761H |
0.778 |
|
| 2011 |
Du Y, Derewacz DK, Deguire SM, Teske J, Ravel J, Sulikowski GA, Bachmann BO. Biosynthesis of the Apoptolidins in Nocardiopsis sp. FU 40. Tetrahedron. 67: 6568-6575. PMID 21869849 DOI: 10.1016/J.Tet.2011.05.106 |
0.33 |
|
| 2011 |
Nannemann DP, Birmingham WR, Scism RA, Bachmann BO. Assessing directed evolution methods for the generation of biosynthetic enzymes with potential in drug biosynthesis. Future Medicinal Chemistry. 3: 809-19. PMID 21644826 DOI: 10.4155/Fmc.11.48 |
0.749 |
|
| 2011 |
Panosian TD, Nannemann DP, Watkins GR, Phelan VV, McDonald WH, Wadzinski BE, Bachmann BO, Iverson TM. Bacillus cereus phosphopentomutase is an alkaline phosphatase family member that exhibits an altered entry point into the catalytic cycle. The Journal of Biological Chemistry. 286: 8043-54. PMID 21193409 DOI: 10.1074/Jbc.M110.201350 |
0.775 |
|
| 2010 |
Vey JL, Al-Mestarihi A, Hu Y, Funk MA, Bachmann BO, Iverson TM. Structure and mechanism of ORF36, an amino sugar oxidizing enzyme in everninomicin biosynthesis . Biochemistry. 49: 9306-17. PMID 20866105 DOI: 10.1021/Bi101336U |
0.792 |
|
| 2010 |
Panosian TD, Nannemann DP, Bachmann BO, Iverson TM. Crystallization and preliminary X-ray analysis of a phosphopentomutase from Bacillus cereus. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 66: 811-4. PMID 20606280 DOI: 10.1107/S1744309110017549 |
0.745 |
|
| 2010 |
Akif M, Ntai I, Sturrock ED, Isaac RE, Bachmann BO, Acharya KR. Crystal structure of a phosphonotripeptide K-26 in complex with angiotensin converting enzyme homologue (AnCE) from Drosophila melanogaster. Biochemical and Biophysical Research Communications. 398: 532-6. PMID 20599761 DOI: 10.1016/J.Bbrc.2010.06.113 |
0.696 |
|
| 2010 |
Nannemann DP, Kaufmann KW, Meiler J, Bachmann BO. Design and directed evolution of a dideoxy purine nucleoside phosphorylase. Protein Engineering, Design & Selection : Peds. 23: 607-16. PMID 20525731 DOI: 10.1093/Protein/Gzq033 |
0.798 |
|
| 2010 |
Bachmann BO, McNees R, Melancon BJ, Ghidu VP, Clark R, Crews BC, Deguire SM, Marnett LJ, Sulikowski GA. Light-induced isomerization of apoptolidin a leads to inversion of C2-C3 double bond geometry. Organic Letters. 12: 2944-7. PMID 20515014 DOI: 10.1021/Ol1009398 |
0.67 |
|
| 2010 |
Du Y, Gisselberg JE, Johnson JD, Lee PJ, Prigge ST, Bachmann BO. Lactococcus lactis fabH, encoding beta-ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum congener. Applied and Environmental Microbiology. 76: 3959-66. PMID 20418430 DOI: 10.1128/Aem.00170-10 |
0.352 |
|
| 2010 |
Carter MD, Phelan VV, Sandlin RD, Bachmann BO, Wright DW. Lipophilic mediated assays for beta-hematin inhibitors. Combinatorial Chemistry & High Throughput Screening. 13: 285-92. PMID 20230372 DOI: 10.2174/138620710790980496 |
0.664 |
|
| 2010 |
Reniere ML, Ukpabi GN, Harry SR, Stec DF, Krull R, Wright DW, Bachmann BO, Murphy ME, Skaar EP. The IsdG-family of haem oxygenases degrades haem to a novel chromophore. Molecular Microbiology. 75: 1529-38. PMID 20180905 DOI: 10.1111/J.1365-2958.2010.07076.X |
0.303 |
|
| 2010 |
Scism RA, Bachmann BO. Five-component cascade synthesis of nucleotide analogues in an engineered self-immobilized enzyme aggregate. Chembiochem : a European Journal of Chemical Biology. 11: 67-70. PMID 19918830 DOI: 10.1002/Cbic.200900620 |
0.763 |
|
| 2009 |
Ghidu VP, Ntai I, Wang J, Jacobs AT, Marnett LJ, Bachmann BO, Sulikowski GA. Combined chemical and biosynthetic route to access a new apoptolidin congener. Organic Letters. 11: 3032-4. PMID 19552384 DOI: 10.1021/Ol901045V |
0.671 |
|
| 2009 |
Phelan VV, Du Y, McLean JA, Bachmann BO. Adenylation enzyme characterization using gamma -(18)O(4)-ATP pyrophosphate exchange. Chemistry & Biology. 16: 473-8. PMID 19477411 DOI: 10.1016/J.Chembiol.2009.04.007 |
0.693 |
|
| 2009 |
Bachmann BO, Ravel J. Chapter 8. Methods for in silico prediction of microbial polyketide and nonribosomal peptide biosynthetic pathways from DNA sequence data. Methods in Enzymology. 458: 181-217. PMID 19374984 DOI: 10.1016/S0076-6879(09)04808-3 |
0.315 |
|
| 2008 |
Hu Y, Al-Mestarihi A, Grimes CL, Kahne D, Bachmann BO. A unifying nitrososynthase involved in nitrosugar biosynthesis. Journal of the American Chemical Society. 130: 15756-7. PMID 18983146 DOI: 10.1021/Ja8051415 |
0.772 |
|
| 2008 |
Hu Y, Phelan VV, Farnet CM, Zazopoulos E, Bachmann BO. Reassembly of anthramycin biosynthetic gene cluster by using recombinogenic cassettes. Chembiochem : a European Journal of Chemical Biology. 9: 1603-8. PMID 18512205 DOI: 10.1002/Cbic.200800029 |
0.748 |
|
| 2008 |
Ntai I, Bachmann BO. Identification of ACE pharmacophore in the phosphonopeptide metabolite K-26. Bioorganic & Medicinal Chemistry Letters. 18: 3068-71. PMID 18096385 DOI: 10.1016/J.Bmcl.2007.11.130 |
0.7 |
|
| 2007 |
Scism RA, Stec DF, Bachmann BO. Synthesis of nucleotide analogues by a promiscuous phosphoribosyltransferase. Organic Letters. 9: 4179-82. PMID 17854193 DOI: 10.1021/Ol7016802 |
0.761 |
|
| 2007 |
Bachmann BO. Foundations for directed alkaloid biosynthesis. Chemistry & Biology. 14: 875-6. PMID 17719485 DOI: 10.1016/J.Chembiol.2007.08.001 |
0.371 |
|
| 2007 |
Hu Y, Phelan V, Ntai I, Farnet CM, Zazopoulos E, Bachmann BO. Benzodiazepine biosynthesis in Streptomyces refuineus. Chemistry & Biology. 14: 691-701. PMID 17584616 DOI: 10.1016/J.Chembiol.2007.05.009 |
0.757 |
|
| 2007 |
Hu Y, Phelan V, Ntai I, Farnet CM, Zazopoulos E, Bachmann BO. Benzodiazepine Biosynthesis in Streptomyces refuineus (DOI:10.1016/j.chembiol.2007.05.009) Chemistry and Biology. 14: 870. DOI: 10.1016/J.Chembiol.2007.07.006 |
0.747 |
|
| 2006 |
Ntai I, Phelan VV, Bachmann BO. Phosphonopeptide K-26 biosynthetic intermediates in Astrosporangium hypotensionis. Chemical Communications (Cambridge, England). 4518-20. PMID 17283804 DOI: 10.1039/B611768F |
0.768 |
|
| 2006 |
Wilkinson B, Bachmann BO. Biocatalysis in pharmaceutical preparation and alteration. Current Opinion in Chemical Biology. 10: 169-76. PMID 16500136 DOI: 10.1016/J.Cbpa.2006.02.006 |
0.314 |
|
| 2005 |
Ntai I, Manier ML, Hachey DL, Bachmann BO. Biosynthetic origins of C-P bond containing tripeptide K-26. Organic Letters. 7: 2763-5. PMID 15957941 DOI: 10.1021/Ol051091D |
0.69 |
|
| 2003 |
Zazopoulos E, Huang K, Staffa A, Liu W, Bachmann BO, Nonaka K, Ahlert J, Thorson JS, Shen B, Farnet CM. A genomics-guided approach for discovering and expressing cryptic metabolic pathways. Nature Biotechnology. 21: 187-90. PMID 12536216 DOI: 10.1038/Nbt784 |
0.358 |
|
| 2002 |
Miller MT, Bachmann BO, Townsend CA, Rosenzweig AC. The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots. Proceedings of the National Academy of Sciences of the United States of America. 99: 14752-7. PMID 12409610 DOI: 10.1073/Pnas.232361199 |
0.538 |
|
| 2002 |
Ahlert J, Shepard E, Lomovskaya N, Zazopoulos E, Staffa A, Bachmann BO, Huang K, Fonstein L, Czisny A, Whitwam RE, Farnet CM, Thorson JS. The calicheamicin gene cluster and its iterative type I enediyne PKS. Science (New York, N.Y.). 297: 1173-6. PMID 12183629 DOI: 10.1126/Science.1072105 |
0.315 |
|
| 2001 |
Miller MT, Bachmann BO, Townsend CA, Rosenzweig AC. Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine. Nature Structural Biology. 8: 684-9. PMID 11473258 DOI: 10.1038/90394 |
0.513 |
|
| 2001 |
Zhou J, Kelly WL, Bachmann BO, Gunsior M, Townsend CA, Solomon EI. Spectroscopic studies of substrate interactions with clavaminate synthase 2, a multifunctional alpha-KG-dependent non-heme iron enzyme: correlation with mechanisms and reactivities. Journal of the American Chemical Society. 123: 7388-98. PMID 11472170 DOI: 10.1021/Ja004025+ |
0.771 |
|
| 2000 |
Bachmann BO, Townsend CA. Kinetic mechanism of the beta-lactam synthetase of Streptomyces clavuligerus. Biochemistry. 39: 11187-93. PMID 10985764 DOI: 10.1021/Bi000709I |
0.585 |
|
| 1998 |
Bachmann BO, Li R, Townsend CA. beta-Lactam synthetase: a new biosynthetic enzyme. Proceedings of the National Academy of Sciences of the United States of America. 95: 9082-6. PMID 9689037 DOI: 10.1073/Pnas.95.16.9082 |
0.542 |
|
| 1998 |
Zhou J, Gunsior M, Bachmann BO, Townsend CA, Solomon EI. Substrate binding to the α-ketoglutarate-dependent non-heme iron enzyme clavaminate synthase 2: Coupling mechanism of oxidative decarboxylation and hydroxylation [14] Journal of the American Chemical Society. 120: 13539-13540. DOI: 10.1021/Ja983534X |
0.763 |
|
| 1995 |
Buynak JD, Wu K, Bachmann B, Khasnis D, Hua L, Nguyen HK, Carver CL. Synthesis and biological activity of 7-alkylidenecephems Journal of Medicinal Chemistry. 38: 1022-1034. PMID 7699694 DOI: 10.1021/Jm00006A022 |
0.39 |
|
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