Chad Cowan - Publications

Affiliations: 
Harvard University, Cambridge, MA, United States 
Area:
Diabetes, Coronary artery disease
Website:
https://hscrb.harvard.edu/res-fl-cowan

51 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Pope BD, Warren CR, Dahl MO, Pizza CV, Henze DE, Sinatra NR, Gonzalez GM, Chang H, Liu Q, Glieberman AL, Ferrier JP, Cowan CA, Parker KK. Fattening chips: hypertrophy, feeding, and fasting of human white adipocytes . Lab On a Chip. PMID 33034335 DOI: 10.1039/D0Lc00508H  0.378
2020 Kanchan K, Iyer K, Yanek LR, Carcamo-Orive I, Taub MA, Malley C, Baldwin K, Becker LC, Broeckel U, Cheng L, Cowan C, D'Antonio M, Frazer KA, Quertermous T, Mostoslavsky G, et al. Genomic integrity of human induced pluripotent stem cells across nine studies in the NHLBI NextGen program. Stem Cell Research. 46: 101803. PMID 32442913 DOI: 10.1016/J.Scr.2020.101803  0.399
2020 Meissner TB, Cowan CA. More Bang for Your Buck: “Off-The-Shelf” Solutions for Cell Replacement Therapy Stemjournal. 2: 1-5. DOI: 10.3233/STJ-200002  0.374
2019 Han X, Wang M, Duan S, Franco PJ, Kenty JH, Hedrick P, Xia Y, Allen A, Ferreira LMR, Strominger JL, Melton DA, Meissner TB, Cowan CA. Generation of hypoimmunogenic human pluripotent stem cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 31040209 DOI: 10.1073/Pnas.1902566116  0.625
2019 Rossmann MP, Hoi K, Chan V, Perlin JR, Hagedorn EJ, Abraham BJ, Yang S, Sullivan LB, Warren CR, Vyas S, Custo-Creig E, Dorjsuren B, Cowan C, Haigis MC, Young RA, et al. Transcriptional Regulation of Coenzyme Q Biosynthesis By TIF1γ Drives Erythropoiesis Blood. 134: 152-152. DOI: 10.1182/Blood-2019-126833  0.394
2018 Odorico J, Markmann J, Melton D, Greenstein J, Hwa A, Nostro C, Rezania A, Oberholzer J, Pipeleers D, Yang L, Cowan C, Huangfu D, Egli D, Ben-David U, Vallier L, et al. Report of the Key Opinion Leaders Meeting on Stem Cell-Derived Beta Cells. Transplantation. PMID 29781950 DOI: 10.1097/Tp.0000000000002217  0.72
2017 Warren CR, O'Sullivan JF, Friesen M, Becker CE, Zhang X, Liu P, Wakabayashi Y, Morningstar JE, Shi X, Choi J, Xia F, Peters DT, Florido MH, Tsankov AM, Duberow E, ... ... Cowan CA, et al. Induced Pluripotent Stem Cell Differentiation Enables Functional Validation of GWAS Variants in Metabolic Disease. Cell Stem Cell. 20: 547-557.e7. PMID 28388431 DOI: 10.1016/J.Stem.2017.01.010  0.333
2017 Lin MI, Paik E, Mishra B, Burkhardt D, Kernytsky A, Pettiglio M, Chen Y, Tomkinson K, Woo A, Cortes M, Tan S, Borland TD, Klein L, Yen A, Mahajan S, ... ... Cowan C, et al. CRISPR/Cas9 Genome Editing to Treat Sickle Cell Disease and B-Thalassemia: Re-Creating Genetic Variants to Upregulate Fetal Hemoglobin Appear Well-Tolerated, Effective and Durable. Blood. 130: 284-284. DOI: 10.1182/Blood.V130.Suppl_1.284.284  0.427
2016 Naylor RW, McGhee CN, Cowan CA, Davidson AJ, Holm TM, Sherwin T. Derivation of Corneal Keratocyte-Like Cells from Human Induced Pluripotent Stem Cells. Plos One. 11: e0165464. PMID 27792791 DOI: 10.1371/journal.pone.0165464  0.423
2016 Peters DT, Henderson CA, Warren CR, Friesen M, Xia F, Becker CE, Musunuru K, Cowan CA. Asialoglycoprotein receptor 1 is a specific cell-surface marker for isolating hepatocytes derived from human pluripotent stem cells. Development (Cambridge, England). 143: 1475-81. PMID 27143754 DOI: 10.1242/dev.132209  0.389
2016 Ferreira LM, Meissner TB, Mikkelsen TS, Mallard W, O'Donnell CW, Tilburgs T, Gomes HA, Camahort R, Sherwood RI, Gifford DK, Rinn JL, Cowan CA, Strominger JL. A distant trophoblast-specific enhancer controls HLA-G expression at the maternal-fetal interface. Proceedings of the National Academy of Sciences of the United States of America. PMID 27078102 DOI: 10.1073/Pnas.1602886113  0.699
2016 Yu H, Cowan CA. Genome Editing of Human Pluripotent Stem Cells for Modeling Metabolic Disease. Molecular Endocrinology (Baltimore, Md.). me20151290. PMID 27075706 DOI: 10.1210/me.2015-1290  0.338
2016 Hendriks WT, Warren CR, Cowan CA. Genome Editing in Human Pluripotent Stem Cells: Approaches, Pitfalls, and Solutions. Cell Stem Cell. 18: 53-65. PMID 26748756 DOI: 10.1016/j.stem.2015.12.002  0.34
2016 Mishra B, Chou S, Lin MI, Paik EJ, Zhang Y, Liang R, Tomkinson K, Pettiglio M, Sanginario A, Allen M, Cradick T, John M, Chakraborty T, Cowan CA, Novak R, et al. Crispr/Cas9- Mediated Genome Editing of Human CD34+ Cells Upregulate Fetal Hemoglobin to Clinically Relevant Levels in Single Cell-Derived Erythroid Colonies Blood. 128: 3623-3623. DOI: 10.1182/Blood.V128.22.3623.3623  0.317
2015 Gupta RM, Meissner TB, Cowan CA, Musunuru K. Genome-Edited Human Pluripotent Stem Cell-Derived Macrophages as a Model of Reverse Cholesterol Transport. Arteriosclerosis, Thrombosis, and Vascular Biology. PMID 26543098 DOI: 10.1161/ATVBAHA.115.305956  0.34
2015 Hendriks WT, Jiang X, Daheron L, Cowan CA. TALEN- and CRISPR/Cas9-Mediated Gene Editing in Human Pluripotent Stem Cells Using Lipid-Based Transfection. Current Protocols in Stem Cell Biology. 34: 5B.3.1-25. PMID 26237572 DOI: 10.1002/9780470151808.sc05b03s34  0.388
2015 Patsch C, Challet-Meylan L, Thoma EC, Urich E, Heckel T, O'Sullivan JF, Grainger SJ, Kapp FG, Sun L, Christensen K, Xia Y, Florido MH, He W, Pan W, Prummer M, ... ... Cowan CA, et al. Generation of vascular endothelial and smooth muscle cells from human pluripotent stem cells. Nature Cell Biology. 17: 994-1003. PMID 26214132 DOI: 10.1038/Ncb3205  0.385
2015 Moisan A, Lee YK, Zhang JD, Hudak CS, Meyer CA, Prummer M, Zoffmann S, Truong HH, Ebeling M, Kiialainen A, Gérard R, Xia F, Schinzel RT, Amrein KE, Cowan CA. White-to-brown metabolic conversion of human adipocytes by JAK inhibition. Nature Cell Biology. 17: 57-67. PMID 25487280 DOI: 10.1038/ncb3075  0.576
2015 Leschik J, Caron L, Yang H, Cowan C, Pucéat M. A view of bivalent epigenetic marks in two human embryonic stem cell lines reveals a different cardiogenic potential. Stem Cells and Development. 24: 384-92. PMID 25202820 DOI: 10.1089/scd.2014.0345  0.376
2015 Leschik J, Caron L, Yang H, Cowan C, Pucéat M. A view of bivalent epigenetic marks in two human embryonic stem cell lines reveals a different cardiogenic potential Stem Cells and Development. 24: 384-392. DOI: 10.1089/scd.2014.0345  0.376
2015 Hendriks WT, Jiang X, Daheron L, Cowan CA. TALEN- and CRISPR/Cas9-mediated gene editing in human pluripotent stem cells using lipid-based transfection Current Protocols in Stem Cell Biology. 2015: 5B.3.1-5B.3.25. DOI: 10.1002/9780470151808.sc05b03s34  0.387
2014 Mandal PK, Ferreira LM, Collins R, Meissner TB, Boutwell CL, Friesen M, Vrbanac V, Garrison BS, Stortchevoi A, Bryder D, Musunuru K, Brand H, Tager AM, Allen TM, Talkowski ME, ... ... Cowan CA, et al. Efficient ablation of genes in human hematopoietic stem and effector cells using CRISPR/Cas9. Cell Stem Cell. 15: 643-52. PMID 25517468 DOI: 10.1016/J.Stem.2014.10.004  0.7
2014 Meissner TB, Mandal PK, Ferreira LM, Rossi DJ, Cowan CA. Genome editing for human gene therapy. Methods in Enzymology. 546: 273-95. PMID 25398345 DOI: 10.1016/B978-0-12-801185-0.00013-1  0.697
2014 Soh BS, Buac K, Xu H, Li E, Ng SY, Wu H, Chmielowiec J, Jiang X, Bu L, Li RA, Cowan C, Chien KR. N-cadherin prevents the premature differentiation of anterior heart field progenitors in the pharyngeal mesodermal microenvironment. Cell Research. 24: 1420-32. PMID 25367124 DOI: 10.1038/Cr.2014.142  0.355
2014 Veres A, Gosis BS, Ding Q, Collins R, Ragavendran A, Brand H, Erdin S, Cowan CA, Talkowski ME, Musunuru K. Low incidence of off-target mutations in individual CRISPR-Cas9 and TALEN targeted human stem cell clones detected by whole-genome sequencing. Cell Stem Cell. 15: 27-30. PMID 24996167 DOI: 10.1016/J.Stem.2014.04.020  0.353
2014 Lee YK, Cowan CA. Differentiation of white and brown adipocytes from human pluripotent stem cells. Methods in Enzymology. 538: 35-47. PMID 24529432 DOI: 10.1016/B978-0-12-800280-3.00003-7  0.413
2014 Roberts LD, Boström P, O'Sullivan JF, Schinzel RT, Lewis GD, Dejam A, Lee YK, Palma MJ, Calhoun S, Georgiadi A, Chen MH, Ramachandran VS, Larson MG, Bouchard C, Rankinen T, ... ... Cowan CA, et al. β-Aminoisobutyric acid induces browning of white fat and hepatic β-oxidation and is inversely correlated with cardiometabolic risk factors. Cell Metabolism. 19: 96-108. PMID 24411942 DOI: 10.1016/J.Cmet.2013.12.003  0.571
2013 Ding Q, Regan SN, Xia Y, Oostrom LA, Cowan CA, Musunuru K. Enhanced efficiency of human pluripotent stem cell genome editing through replacing TALENs with CRISPRs Cell Stem Cell. 12: 393-394. PMID 23561441 DOI: 10.1016/j.stem.2013.03.006  0.384
2013 Mae S, Shono A, Shiota F, Yasuno T, Kajiwara M, Gotoda-Nishimura N, Arai S, Sato-Otubo A, Toyoda T, Takahashi K, Nakayama N, Cowan CA, Aoi T, Ogawa S, McMahon AP, et al. Monitoring and robust induction of nephrogenic intermediate mesoderm from human pluripotent stem cells. Nature Communications. 4: 1367. PMID 23340407 DOI: 10.1038/Ncomms2378  0.444
2013 Ding Q, Lee YK, Schaefer EA, Peters DT, Veres A, Kim K, Kuperwasser N, Motola DL, Meissner TB, Hendriks WT, Trevisan M, Gupta RM, Moisan A, Banks E, Friesen M, ... ... Cowan CA, et al. A TALEN genome-editing system for generating human stem cell-based disease models. Cell Stem Cell. 12: 238-51. PMID 23246482 DOI: 10.1016/J.Stem.2012.11.011  0.67
2012 Mou H, Zhao R, Sherwood R, Ahfeldt T, Lapey A, Wain J, Sicilian L, Izvolsky K, Musunuru K, Cowan C, Rajagopal J. Generation of multipotent lung and airway progenitors from mouse ESCs and patient-specific cystic fibrosis iPSCs. Cell Stem Cell. 10: 385-97. PMID 22482504 DOI: 10.1016/J.Stem.2012.01.018  0.714
2012 Ahfeldt T, Schinzel RT, Lee YK, Hendrickson D, Kaplan A, Lum DH, Camahort R, Xia F, Shay J, Rhee EP, Clish CB, Deo RC, Shen T, Lau FH, Cowley A, ... ... Cowan CA, et al. Programming human pluripotent stem cells into white and brown adipocytes. Nature Cell Biology. 14: 209-19. PMID 22246346 DOI: 10.1038/Ncb2411  0.687
2011 Schinzel RT, Ahfeldt T, Lau FH, Lee YK, Cowley A, Shen T, Peters D, Lum DH, Cowan CA. Efficient culturing and genetic manipulation of human pluripotent stem cells. Plos One. 6: e27495. PMID 22194785 DOI: 10.1371/journal.pone.0027495  0.618
2011 Staal FJ, Baum C, Cowan C, Dzierzak E, Hacein-Bey-Abina S, Karlsson S, Lapidot T, Lemischka I, Mendez-Ferrer S, Mikkers H, Moore K, Moreno E, Mummery CL, Robin C, Suda T, et al. Stem cell self-renewal: lessons from bone marrow, gut and iPS toward clinical applications. Leukemia. 25: 1095-102. PMID 21527933 DOI: 10.1038/Leu.2011.52  0.408
2011 Rigamonti A, Brennand K, Lau F, Cowan CA. Rapid cellular turnover in adipose tissue. Plos One. 6: e17637. PMID 21407813 DOI: 10.1371/Journal.Pone.0017637  0.535
2010 Warren L, Manos PD, Ahfeldt T, Loh YH, Li H, Lau F, Ebina W, Mandal PK, Smith ZD, Meissner A, Daley GQ, Brack AS, Collins JJ, Cowan C, Schlaeger TM, et al. Highly efficient reprogramming to pluripotency and directed differentiation of human cells with synthetic modified mRNA. Cell Stem Cell. 7: 618-30. PMID 20888316 DOI: 10.1016/J.Stem.2010.08.012  0.422
2010 Blin G, Nury D, Stefanovic S, Neri T, Guillevic O, Brinon B, Bellamy V, Rücker-Martin C, Barbry P, Bel A, Bruneval P, Cowan C, Pouly J, Mitalipov S, Gouadon E, et al. A purified population of multipotent cardiovascular progenitors derived from primate pluripotent stem cells engrafts in postmyocardial infarcted nonhuman primates. The Journal of Clinical Investigation. 120: 1125-39. PMID 20335662 DOI: 10.1172/JCI40120  0.394
2010 Tenzen T, Zembowicz F, Cowan CA. Genome modification in human embryonic stem cells Journal of Cellular Physiology. 222: 278-281. PMID 19877154 DOI: 10.1002/jcp.21948  0.379
2009 Lau F, Ahfeldt T, Osafune K, Akustsu H, Cowan CA. Induced pluripotent stem (iPS) cells: an up-to-the-minute review. F1000 Biology Reports. 1: 84. PMID 20948605 DOI: 10.3410/B1-84  0.405
2009 Stefanovic S, Abboud N, Désilets S, Nury D, Cowan C, Pucéat M. Interplay of Oct4 with Sox2 and Sox17: a molecular switch from stem cell pluripotency to specifying a cardiac fate. The Journal of Cell Biology. 186: 665-73. PMID 19736317 DOI: 10.1083/Jcb.200901040  0.5
2009 Chen AE, Egli D, Niakan K, Deng J, Akutsu H, Yamaki M, Cowan C, Fitz-Gerald C, Zhang K, Melton DA, Eggan K. Optimal timing of inner cell mass isolation increases the efficiency of human embryonic stem cell derivation and allows generation of sibling cell lines. Cell Stem Cell. 4: 103-6. PMID 19200798 DOI: 10.1016/J.Stem.2008.12.001  0.628
2008 Maherali N, Ahfeldt T, Rigamonti A, Utikal J, Cowan C, Hochedlinger K. A high-efficiency system for the generation and study of human induced pluripotent stem cells. Cell Stem Cell. 3: 340-5. PMID 18786420 DOI: 10.1016/J.Stem.2008.08.003  0.519
2008 Park IH, Arora N, Huo H, Maherali N, Ahfeldt T, Shimamura A, Lensch MW, Cowan C, Hochedlinger K, Daley GQ. Disease-specific induced pluripotent stem cells. Cell. 134: 877-86. PMID 18691744 DOI: 10.1016/J.Cell.2008.07.041  0.413
2008 Fenno LE, Ptaszek LM, Cowan CA. Human embryonic stem cells: emerging technologies and practical applications Current Opinion in Genetics and Development. 18: 324-329. PMID 18625311 DOI: 10.1016/j.gde.2008.06.004  0.426
2008 Osafune K, Caron L, Borowiak M, Martinez RJ, Fitz-Gerald CS, Sato Y, Cowan CA, Chien KR, Melton DA. Marked differences in differentiation propensity among human embryonic stem cell lines. Nature Biotechnology. 26: 313-5. PMID 18278034 DOI: 10.1038/Nbt1383  0.572
2007 Ptaszek LM, Cowan CA. New Tools for Genome Modification in Human Embryonic Stem Cells Cell Stem Cell. 1: 600-602. PMID 18371400 DOI: 10.1016/j.stem.2007.11.004  0.324
2006 Akutsu H, Cowan CA, Melton D. Human Embryonic Stem Cells Methods in Enzymology. 418: 78-92. PMID 17141030 DOI: 10.1016/S0076-6879(06)18005-2  0.612
2005 Cowan CA, Atienza J, Melton DA, Eggan K. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science (New York, N.Y.). 309: 1369-73. PMID 16123299 DOI: 10.1126/Science.1116447  0.634
2004 Annerén C, Cowan CA, Melton DA. The Src family of tyrosine kinases is important for embryonic stem cell self-renewal. The Journal of Biological Chemistry. 279: 31590-8. PMID 15148312 DOI: 10.1074/jbc.M403547200  0.516
2004 Cowan CA, Klimanskaya I, McMahon J, Atienza J, Witmyer J, Zucker JP, Wang S, Morton CC, McMahon AP, Powers D, Melton DA. Derivation of embryonic stem-cell lines from human blastocysts. The New England Journal of Medicine. 350: 1353-6. PMID 14999088 DOI: 10.1056/Nejmsr040330  0.584
2004 Wang S, Cowan C, Melton D, Powers D. Up-regulation of transcriptional factor E2F-1 in mammalian embryos: a lesson from gene expression profiles by DNA microarray Fertility and Sterility. 81: 10. DOI: 10.1016/J.Fertnstert.2004.02.084  0.366
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