| Year |
Citation |
Score |
| 2024 |
Charalampidou A, Nehls T, Meyners C, Gandhesiri S, Pomplun S, Pentelute BL, Lermyte F, Hausch F. Automated Flow Peptide Synthesis Enables Engineering of Proteins with Stabilized Transient Binding Pockets. Acs Central Science. 10: 649-657. PMID 38559286 DOI: 10.1021/acscentsci.3c01283 |
0.733 |
|
| 2024 |
Stransky F, Kostrz D, Follenfant M, Pomplun S, Meyners C, Strick T, Hausch F, Gosse C. Use of DNA forceps to measure receptor-ligand dissociation equilibrium constants in a single-molecule competition assay. Methods in Enzymology. 694: 51-82. PMID 38492958 DOI: 10.1016/bs.mie.2024.01.010 |
0.711 |
|
| 2023 |
Baischew A, Engel S, Taubert MC, Geiger TM, Hausch F. Large-scale, in-cell photocrosslinking at single-residue resolution reveals the molecular basis for glucocorticoid receptor regulation by immunophilins. Nature Structural & Molecular Biology. PMID 37945739 DOI: 10.1038/s41594-023-01098-1 |
0.311 |
|
| 2023 |
Lerma Romero JA, Meyners C, Rupp N, Hausch F, Kolmar H. A protein engineering approach toward understanding FKBP51 conformational dynamics and mechanisms of ligand binding. Protein Engineering, Design & Selection : Peds. 36. PMID 37903068 DOI: 10.1093/protein/gzad014 |
0.346 |
|
| 2023 |
Purder PL, Meyners C, Sugiarto WO, Kolos J, Löhr F, Gebel J, Nehls T, Dötsch V, Lermyte F, Hausch F. Deconstructing Protein Binding of Sulfonamides and Sulfonamide Analogues. Jacs Au. 3: 2478-2486. PMID 37772190 DOI: 10.1021/jacsau.3c00241 |
0.32 |
|
| 2023 |
Buffa V, Knaup FH, Heymann T, Springer M, Schmidt MV, Hausch F. Analysis of the Selective Antagonist SAFit2 as a Chemical Probe for the FK506-Binding Protein 51. Acs Pharmacology & Translational Science. 6: 361-371. PMID 36926456 DOI: 10.1021/acsptsci.2c00234 |
0.311 |
|
| 2022 |
Lerma Romero JA, Meyners C, Christmann A, Reinbold LM, Charalampidou A, Hausch F, Kolmar H. Binding pocket stabilization by high-throughput screening of yeast display libraries. Frontiers in Molecular Biosciences. 9: 1023131. PMID 36419931 DOI: 10.3389/fmolb.2022.1023131 |
0.345 |
|
| 2021 |
Kolos JM, Pomplun S, Jung S, Rieß B, Purder PL, Voll AM, Merz S, Gnatzy M, Geiger TM, Quist-Løkken I, Jatzlau J, Knaus P, Holien T, Bracher A, Meyners C, ... ... Hausch F, et al. Picomolar FKBP inhibitors enabled by a single water-displacing methyl group in bicyclic [4.3.1] aza-amides. Chemical Science. 12: 14758-14765. PMID 34820091 DOI: 10.1039/d1sc04638a |
0.741 |
|
| 2021 |
Gnatzy MT, Geiger TM, Kuehn A, Gutfreund N, Walz M, Kolos JM, Hausch F. Development of NanoBRET-Binding Assays for FKBP-Ligand Profiling in Living Cells. Chembiochem : a European Journal of Chemical Biology. PMID 33887102 DOI: 10.1002/cbic.202100113 |
0.309 |
|
| 2021 |
Voll AM, Meyners C, Taubert MC, Bajaj T, Heymann T, Merz S, Charalampidou A, Kolos J, Purder PL, Geiger TM, Wessig P, Gassen NC, Bracher A, Hausch F. Macrocyclic FKBP51 ligands define a transient binding mode with enhanced selectivity. Angewandte Chemie (International Ed. in English). PMID 33843131 DOI: 10.1002/anie.202017352 |
0.324 |
|
| 2021 |
Bauder M, Meyners C, Purder PL, Merz S, Sugiarto WO, Voll AM, Heymann T, Hausch F. Structure-Based Design of High-Affinity Macrocyclic FKBP51 Inhibitors. Journal of Medicinal Chemistry. PMID 33666419 DOI: 10.1021/acs.jmedchem.0c02195 |
0.325 |
|
| 2019 |
Bischoff M, Mayer P, Meyners C, Hausch F. Enantioselective Synthesis of a Tricyclic, sp3-Rich Diazatetradecanedione: an Amino Acid-Based Natural Product-Like Scaffold. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 31846111 DOI: 10.1002/Chem.201905144 |
0.319 |
|
| 2019 |
Feng X, Sippel C, Knaup F, Bracher A, Staibano S, Romano MF, Hausch F. A novel decalin-based bicyclic scaffold for FKBP51-selective ligands. Journal of Medicinal Chemistry. PMID 31800244 DOI: 10.1021/Acs.Jmedchem.9B01157 |
0.408 |
|
| 2019 |
Tietze D, Kaufmann D, Tietze AA, Voll A, Reher R, König G, Hausch F. Structural and Dynamical Basis of G Protein Inhibition by YM-254890 and FR900359: An Inhibitor in Action. Journal of Chemical Information and Modeling. 59: 4361-4373. PMID 31539242 DOI: 10.1021/Acs.Jcim.9B00433 |
0.339 |
|
| 2019 |
Hähle A, Geiger TM, Merz S, Meyners C, Tianqi M, Kolos J, Hausch F. FKBP51 and FKBP12.6-Novel and tight interactors of Glomulin. Plos One. 14: e0221926. PMID 31490997 DOI: 10.1371/Journal.Pone.0221926 |
0.416 |
|
| 2019 |
Kumar Ankush Jagtap P, Asami S, Sippel C, Kaila V, Hausch F, Sattler M. Selective inhibitors of FKBP51 employ conformational selection of dynamic invisible states. Angewandte Chemie (International Ed. in English). PMID 31100184 DOI: 10.1002/Anie.201902994 |
0.373 |
|
| 2018 |
Kolos JM, Voll AM, Bauder M, Hausch F. FKBP Ligands-Where We Are and Where to Go? Frontiers in Pharmacology. 9: 1425. PMID 30568592 DOI: 10.3389/Fphar.2018.01425 |
0.424 |
|
| 2018 |
Pöhlmann ML, Häusl AS, Harbich D, Balsevich G, Engelhardt C, Feng X, Breitsamer M, Hausch F, Winter G, Schmidt MV. Pharmacological Modulation of the Psychiatric Risk Factor FKBP51 Alters Efficiency of Common Antidepressant Drugs. Frontiers in Behavioral Neuroscience. 12: 262. PMID 30483074 DOI: 10.3389/Fnbeh.2018.00262 |
0.321 |
|
| 2018 |
Pomplun S, Sippel C, Hähle A, Tay D, Shima K, Klages A, Ünal CM, Rieß B, Toh HT, Hansen G, Yoon HS, Bracher A, Preiser PR, Rupp J, Steinert M, ... Hausch F, et al. Chemogenomic profiling of human and microbial FK506-binding proteins. Journal of Medicinal Chemistry. PMID 29578710 DOI: 10.1021/Acs.Jmedchem.8B00137 |
0.758 |
|
| 2017 |
Hausch F. Cryo-EM Structures of Class B GPCR Reveal the Activation Mechanism. Angewandte Chemie (International Ed. in English). 56: 12412-12414. PMID 28834010 DOI: 10.1002/Anie.201707200 |
0.32 |
|
| 2017 |
Schuster M, Schnell L, Feigl P, Birkhofer C, Mohr K, Roeder M, Carle S, Langer S, Tippel F, Buchner J, Fischer G, Hausch F, Frick M, Schwan C, Aktories K, et al. The Hsp90 machinery facilitates the transport of diphtheria toxin into human cells. Scientific Reports. 7: 613. PMID 28377614 DOI: 10.1038/S41598-017-00780-X |
0.347 |
|
| 2017 |
Gjerstad JKB, Zhao Z, Feng X, Hausch F, Lightman SL, Spiga F. Sexually diergic effect of FK506 binding protein 51 (FKBP-51) inhibition on the ultradian rhythm of corticosterone in the rat European Neuropsychopharmacology. 27. DOI: 10.1016/S0924-977X(17)30075-5 |
0.317 |
|
| 2016 |
Gaali S, Feng X, Hähle A, Sippel C, Bracher A, Hausch F. Rapid, Structure-Based Exploration of Pipecolic Acid Amides as Novel Selective Antagonists of the FK506-Binding Protein 51. Journal of Medicinal Chemistry. 59: 2410-22. PMID 26954324 DOI: 10.1021/Acs.Jmedchem.5B01355 |
0.469 |
|
| 2016 |
Kirmeier T, Gopalakrishnan R, Gormanns V, Werner AM, Cuboni S, Rudolf GC, Höfner G, Wanner KT, Sieber SA, Schmidt U, Holsboer F, Rein T, Hausch F. Azidobupramine, an Antidepressant-Derived Bifunctional Neurotransmitter Transporter Ligand Allowing Covalent Labeling and Attachment of Fluorophores. Plos One. 11: e0148608. PMID 26863431 DOI: 10.1371/Journal.Pone.0148608 |
0.376 |
|
| 2015 |
Feng X, Sippel C, Bracher A, Hausch F. Structure-Affinity Relationship Analysis of Selective FKBP51 Ligands. Journal of Medicinal Chemistry. 58: 7796-806. PMID 26419422 DOI: 10.1021/Acs.Jmedchem.5B00785 |
0.447 |
|
| 2015 |
Hartmann J, Wagner KV, Gaali S, Kirschner A, Kozany C, Rühter G, Dedic N, Häusl AS, Hoeijmakers L, Westerholz S, Namendorf C, Gerlach T, Uhr M, Chen A, Deussing JM, ... ... Hausch F, et al. Pharmacological Inhibition of the Psychiatric Risk Factor FKBP51 Has Anxiolytic Properties. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 9007-16. PMID 26085626 DOI: 10.1523/Jneurosci.4024-14.2015 |
0.316 |
|
| 2015 |
Feng X, Pomplun S, Hausch F. Recent Progress in FKBP Ligand Development. Current Molecular Pharmacology. 9: 27-36. PMID 25986570 DOI: 10.2174/1874467208666150519113313 |
0.752 |
|
| 2015 |
Riebold M, Kozany C, Freiburger L, Sattler M, Buchfelder M, Hausch F, Stalla GK, Paez-Pereda M. A C-terminal HSP90 inhibitor restores glucocorticoid sensitivity and relieves a mouse allograft model of Cushing disease. Nature Medicine. 21: 276-80. PMID 25665180 DOI: 10.1038/Nm.3776 |
0.314 |
|
| 2015 |
Hausch F. FKBPs and their role in neuronal signaling. Biochimica Et Biophysica Acta. 1850: 2035-40. PMID 25615537 DOI: 10.1016/J.Bbagen.2015.01.012 |
0.394 |
|
| 2015 |
Gaali S, Kirschner A, Cuboni S, Hartmann J, Kozany C, Balsevich G, Namendorf C, Fernandez-Vizarra P, Sippel C, Zannas AS, Draenert R, Binder EB, Almeida OF, Rühter G, Uhr M, ... ... Hausch F, et al. Selective inhibitors of the FK506-binding protein 51 by induced fit. Nature Chemical Biology. 11: 33-7. PMID 25436518 DOI: 10.1038/Nchembio.1699 |
0.457 |
|
| 2015 |
Pomplun S, Wang Y, Kirschner A, Kozany C, Bracher A, Hausch F. Rational design and asymmetric synthesis of potent and neurotrophic ligands for FK506-binding proteins (FKBPs). Angewandte Chemie (International Ed. in English). 54: 345-8. PMID 25412894 DOI: 10.1002/Anie.201408776 |
0.761 |
|
| 2014 |
Cuboni S, Devigny C, Hoogeland B, Strasser A, Pomplun S, Hauger B, Höfner G, Wanner KT, Eder M, Buschauer A, Holsboer F, Hausch F. Loratadine and analogues: discovery and preliminary structure-activity relationship of inhibitors of the amino acid transporter B(0)AT2. Journal of Medicinal Chemistry. 57: 9473-9. PMID 25318072 DOI: 10.1021/Jm501086V |
0.719 |
|
| 2014 |
Bischoff M, Sippel C, Bracher A, Hausch F. Stereoselective construction of the 5-hydroxy diazabicyclo[4.3.1]decane-2-one scaffold, a privileged motif for FK506-binding proteins. Organic Letters. 16: 5254-7. PMID 25286062 DOI: 10.1021/Ol5023195 |
0.376 |
|
| 2014 |
Cuboni S, Hausch F. Snapshot of antidepressants at work: the structure of neurotransmitter transporter proteins. Angewandte Chemie (International Ed. in English). 53: 5008-9. PMID 24729171 DOI: 10.1002/Anie.201310567 |
0.341 |
|
| 2014 |
Riebold M, Theodoropoulou M, Kozany C, Hausch F, Stalla GK, Paez-Pereda M. C-terminal Hsp90 inhibitors restore glucocorticoid sensitivity in an experimental model for Cushing's disease Experimental and Clinical Endocrinology & Diabetes. 122: 32. DOI: 10.1055/S-0034-1372049 |
0.333 |
|
| 2014 |
Pomplun S, Wang Y, Kirschner A, Kozany C, Bracher A, Hausch F. Rationales Design und asymmetrische Synthese potenter neuritotropher Liganden für FK506-bindende Proteine (FKBPs) Angewandte Chemie. 127: 352-355. DOI: 10.1002/Ange.201408776 |
0.716 |
|
| 2013 |
Hausch F. Structures of class B G protein-coupled receptors: prospects for drug discovery. Angewandte Chemie (International Ed. in English). 52: 12783-5. PMID 24127232 DOI: 10.1002/Anie.201307542 |
0.366 |
|
| 2013 |
Bracher A, Kozany C, Hähle A, Wild P, Zacharias M, Hausch F. Crystal structures of the free and ligand-bound FK1-FK2 domain segment of FKBP52 reveal a flexible inter-domain hinge. Journal of Molecular Biology. 425: 4134-44. PMID 23933011 DOI: 10.1016/J.Jmb.2013.07.041 |
0.387 |
|
| 2013 |
Hausch F, Kozany C, Theodoropoulou M, Fabian AK. FKBPs and the Akt/mTOR pathway. Cell Cycle (Georgetown, Tex.). 12: 2366-70. PMID 23839048 DOI: 10.4161/Cc.25508 |
0.407 |
|
| 2013 |
Wang Y, Kirschner A, Fabian AK, Gopalakrishnan R, Kress C, Hoogeland B, Koch U, Kozany C, Bracher A, Hausch F. Increasing the efficiency of ligands for FK506-binding protein 51 by conformational control. Journal of Medicinal Chemistry. 56: 3922-35. PMID 23647266 DOI: 10.1021/Jm400087K |
0.432 |
|
| 2013 |
Fabian AK, März A, Neimanis S, Biondi RM, Kozany C, Hausch F. InterAKTions with FKBPs--mutational and pharmacological exploration. Plos One. 8: e57508. PMID 23469007 DOI: 10.1371/Journal.Pone.0057508 |
0.344 |
|
| 2013 |
März AM, Fabian AK, Kozany C, Bracher A, Hausch F. Large FK506-binding proteins shape the pharmacology of rapamycin. Molecular and Cellular Biology. 33: 1357-67. PMID 23358420 DOI: 10.1128/Mcb.00678-12 |
0.39 |
|
| 2012 |
Hausch F, Holsboer F. Structural biology: Snapshot of an activated peptide receptor. Nature. 490: 492-3. PMID 23051750 DOI: 10.1038/Nature11634 |
0.324 |
|
| 2012 |
Hartmann J, Wagner KV, Dedic N, Marinescu D, Scharf SH, Wang XD, Deussing JM, Hausch F, Rein T, Schmidt U, Holsboer F, Müller MB, Schmidt MV. Fkbp52 heterozygosity alters behavioral, endocrine and neurogenetic parameters under basal and chronic stress conditions in mice. Psychoneuroendocrinology. 37: 2009-21. PMID 22641006 DOI: 10.1016/J.Psyneuen.2012.04.017 |
0.342 |
|
| 2012 |
Schmidt MV, Paez-Pereda M, Holsboer F, Hausch F. The prospect of FKBP51 as a drug target. Chemmedchem. 7: 1351-9. PMID 22581765 DOI: 10.1002/Cmdc.201200137 |
0.375 |
|
| 2012 |
Gopalakrishnan R, Kozany C, Gaali S, Kress C, Hoogeland B, Bracher A, Hausch F. Evaluation of synthetic FK506 analogues as ligands for the FK506-binding proteins 51 and 52. Journal of Medicinal Chemistry. 55: 4114-22. PMID 22455444 DOI: 10.1021/Jm201746X |
0.451 |
|
| 2012 |
Gopalakrishnan R, Kozany C, Wang Y, Schneider S, Hoogeland B, Bracher A, Hausch F. Exploration of pipecolate sulfonamides as binders of the FK506-binding proteins 51 and 52. Journal of Medicinal Chemistry. 55: 4123-31. PMID 22455398 DOI: 10.1021/Jm201747C |
0.422 |
|
| 2012 |
Hartmann J, Wagner KV, Liebl C, Scharf SH, Wang XD, Wolf M, Hausch F, Rein T, Schmidt U, Touma C, Cheung-Flynn J, Cox MB, Smith DF, Holsboer F, Müller MB, et al. The involvement of FK506-binding protein 51 (FKBP5) in the behavioral and neuroendocrine effects of chronic social defeat stress. Neuropharmacology. 62: 332-9. PMID 21839098 DOI: 10.1016/J.Neuropharm.2011.07.041 |
0.332 |
|
| 2011 |
Gaali S, Gopalakrishnan R, Wang Y, Kozany C, Hausch F. The chemical biology of immunophilin ligands. Current Medicinal Chemistry. 18: 5355-79. PMID 22087830 DOI: 10.2174/092986711798194342 |
0.35 |
|
| 2011 |
Touma C, Gassen NC, Herrmann L, Cheung-Flynn J, Büll DR, Ionescu IA, Heinzmann JM, Knapman A, Siebertz A, Depping AM, Hartmann J, Hausch F, Schmidt MV, Holsboer F, Ising M, et al. FK506 binding protein 5 shapes stress responsiveness: modulation of neuroendocrine reactivity and coping behavior. Biological Psychiatry. 70: 928-36. PMID 21907973 DOI: 10.1016/J.Biopsych.2011.07.023 |
0.33 |
|
| 2011 |
Gräber M, Janczyk W, Sperl B, Elumalai N, Kozany C, Hausch F, Holak TA, Berg T. Selective targeting of disease-relevant protein binding domains by O-phosphorylated natural product derivatives. Acs Chemical Biology. 6: 1008-14. PMID 21797253 DOI: 10.1021/Cb2001796 |
0.379 |
|
| 2011 |
Bracher A, Kozany C, Thost AK, Hausch F. Structural characterization of the PPIase domain of FKBP51, a cochaperone of human Hsp90. Acta Crystallographica. Section D, Biological Crystallography. 67: 549-59. PMID 21636895 DOI: 10.1107/S0907444911013862 |
0.44 |
|
| 2011 |
Devigny C, Perez-Balderas F, Hoogeland B, Cuboni S, Wachtel R, Mauch CP, Webb KJ, Deussing JM, Hausch F. Biomimetic screening of class-B G protein-coupled receptors. Journal of the American Chemical Society. 133: 8927-33. PMID 21534574 DOI: 10.1021/Ja200160S |
0.388 |
|
| 2011 |
Devigny C, Perez-Balderas F, Hoogeland B, Cuboni S, Webb K, Deussing JM, Hausch F. Biomimetic screening of class B G protein-coupled receptors Pharmacopsychiatry. 44: 288-288. DOI: 10.1055/S-0031-1292463 |
0.307 |
|
| 2011 |
Hartmann J, Wagner K, Hausch F, Rein T, Schmidt U, Touma C, Müller M, Schmidt M. S.04.04 The involvement of FK506-binding protein 51 (FKBP51) in the behavioural and neuroendocrine effects of acute and chronic stress European Neuropsychopharmacology. 21: S189-S190. DOI: 10.1016/S0924-977X(11)70248-6 |
0.352 |
|
| 2010 |
Gaali S, Kozany C, Hoogeland B, Klein M, Hausch F. Facile synthesis of a fluorescent cyclosporin a analogue to study cyclophilin 40 and cyclophilin 18 ligands. Acs Medicinal Chemistry Letters. 1: 536-9. PMID 24900244 DOI: 10.1021/Ml1001272 |
0.357 |
|
| 2009 |
Kozany C, März A, Kress C, Hausch F. Fluorescent probes to characterise FK506-binding proteins. Chembiochem : a European Journal of Chemical Biology. 10: 1402-10. PMID 19418507 DOI: 10.1002/Cbic.200800806 |
0.392 |
|
| 2009 |
Laenger A, Lang-Rollin I, Kozany C, Zschocke J, Zimmermann N, Rüegg J, Holsboer F, Hausch F, Rein T. XAP2 inhibits glucocorticoid receptor activity in mammalian cells. Febs Letters. 583: 1493-8. PMID 19375531 DOI: 10.1016/J.Febslet.2009.03.072 |
0.348 |
|
| 2009 |
Kozany C, März A, Kress C, Hoogeland B, Hausch F. Development of specific inhibitors for the FK506 binding proteins 51 and 52 Pharmacopsychiatry. 42: 227-228. DOI: 10.1055/S-0029-1240159 |
0.418 |
|
| 2009 |
Devigny C, Perez-Balderas F, Hoogeland B, Hausch F. Biomimetic screening of CRHR ligands Pharmacopsychiatry. 42: 215-215. DOI: 10.1055/S-0029-1240100 |
0.302 |
|
| 2003 |
Hausch F, Halttunen T, Mäki M, Khosla C. Design, synthesis, and evaluation of gluten peptide analogs as selective inhibitors of human tissue transglutaminase. Chemistry & Biology. 10: 225-31. PMID 12670536 DOI: 10.1016/S1074-5521(03)00045-0 |
0.329 |
|
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