| Year |
Citation |
Score |
| 2022 |
Border R, Athanasiadis G, Buil A, Schork AJ, Cai N, Young AI, Werge T, Flint J, Kendler KS, Sankararaman S, Dahl AW, Zaitlen NA. Cross-trait assortative mating is widespread and inflates genetic correlation estimates. Science (New York, N.Y.). 378: 754-761. PMID 36395242 DOI: 10.1126/science.abo2059 |
0.328 |
|
| 2021 |
Zou J, Gopalakrishnan S, Parker CC, Nicod J, Mott R, Cai N, Lionikas A, Davies RW, Palmer AA, Flint J. Analysis of independent cohorts of outbred CFW mice reveals novel loci for behavioral and physiological traits and identifies factors determining reproducibility. G3 (Bethesda, Md.). PMID 34791208 DOI: 10.1093/g3journal/jkab394 |
0.404 |
|
| 2020 |
Chatzinakos C, Georgiadis F, Lee D, Cai N, Vladimirov VI, Docherty A, Webb BT, Riley BP, Flint J, Kendler KS, Daskalakis NP, Bacanu SA. TWAS pathway method greatly enhances the number of leads for uncovering the molecular underpinnings of psychiatric disorders. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. PMID 32954640 DOI: 10.1002/Ajmg.B.32823 |
0.31 |
|
| 2020 |
Cai N, Revez JA, Adams MJ, Andlauer TFM, Breen G, Byrne EM, Clarke TK, Forstner AJ, Grabe HJ, Hamilton SP, Levinson DF, Lewis CM, Lewis G, Martin NG, Milaneschi Y, ... ... Flint J, et al. Minimal phenotyping yields genome-wide association signals of low specificity for major depression. Nature Genetics. PMID 32231276 DOI: 10.1038/S41588-020-0594-5 |
0.314 |
|
| 2019 |
Dahl A, Cai N, Ko A, Laakso M, Pajukanta P, Flint J, Zaitlen N. Reverse GWAS: Using genetics to identify and model phenotypic subtypes. Plos Genetics. 15: e1008009. PMID 30951530 DOI: 10.1371/Journal.Pgen.1008009 |
0.322 |
|
| 2018 |
Weissbrod O, Flint J, Rosset S. Estimating SNP-Based Heritability and Genetic Correlation in Case-Control Studies Directly and with Summary Statistics. American Journal of Human Genetics. 103: 89-99. PMID 29979983 DOI: 10.1016/J.Ajhg.2018.06.002 |
0.307 |
|
| 2016 |
Peterson RE, Cai N, Bigdeli TB, Li Y, Reimers M, Nikulova A, Webb BT, Bacanu SA, Riley BP, Flint J, Kendler KS. The Genetic Architecture of Major Depressive Disorder in Han Chinese Women. Jama Psychiatry. PMID 28002544 DOI: 10.1001/Jamapsychiatry.2016.3578 |
0.315 |
|
| 2016 |
Nicod J, Davies RW, Cai N, Hassett C, Goodstadt L, Cosgrove C, Yee BK, Lionikaite V, McIntyre RE, Remme CA, Lodder EM, Gregory JS, Hough T, Joynson R, Phelps H, ... ... Flint J, et al. Genome-wide association of multiple complex traits in outbred mice by ultra-low-coverage sequencing. Nature Genetics. PMID 27376238 DOI: 10.1038/Ng.3595 |
0.353 |
|
| 2016 |
Gage SH, Davey Smith G, Ware JJ, Flint J, Munafò MR. G = E: What GWAS Can Tell Us about the Environment. Plos Genetics. 12: e1005765. PMID 26866486 DOI: 10.1371/journal.pgen.1005765 |
0.317 |
|
| 2014 |
Munafò MR, Flint J. The genetic architecture of psychophysiological phenotypes Psychophysiology. 51: 1331-1332. PMID 25387716 DOI: 10.1111/psyp.12355 |
0.361 |
|
| 2014 |
Flint J, Timpson N, Munafò M. Assessing the utility of intermediate phenotypes for genetic mapping of psychiatric disease Trends in Neurosciences. 37: 733-741. PMID 25216981 DOI: 10.1016/j.tins.2014.08.007 |
0.349 |
|
| 2014 |
Krohn J, Speed D, Palme R, Touma C, Mott R, Flint J. Genetic interactions with sex make a relatively small contribution to the heritability of complex traits in mice. Plos One. 9: e96450. PMID 24811081 DOI: 10.1371/Journal.Pone.0096450 |
0.419 |
|
| 2014 |
Flint J, Kendler KS. The genetics of major depression. Neuron. 81: 484-503. PMID 24507187 DOI: 10.1016/j.neuron.2014.01.027 |
0.332 |
|
| 2013 |
White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, ... ... Flint J, et al. Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes. Cell. 154: 452-64. PMID 23870131 DOI: 10.1016/J.Cell.2013.06.022 |
0.312 |
|
| 2013 |
Baud A, Calderari S, Mott R, Flint J, Gauguier D. [Genome sequencing and genetic mapping to dissect the genetic basis of complex traits]. MéDecine Sciences : M/S. 29: 671-4. PMID 23859526 DOI: 10.1051/Medsci/2013296024 |
0.352 |
|
| 2013 |
Mott R, Flint J. Dissecting quantitative traits in mice. Annual Review of Genomics and Human Genetics. 14: 421-39. PMID 23834320 DOI: 10.1146/Annurev-Genom-091212-153419 |
0.412 |
|
| 2013 |
Baud A, Hermsen R, Guryev V, Stridh P, Graham D, McBride MW, Foroud T, Calderari S, Diez M, Ockinger J, Beyeen AD, Gillett A, Abdelmagid N, Guerreiro-Cacais AO, ... ... Flint J, et al. Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nature Genetics. 45: 767-75. PMID 23708188 DOI: 10.1038/Ng.2644 |
0.417 |
|
| 2013 |
Flint J, Munafò MR. Candidate and non-candidate genes in behavior genetics Current Opinion in Neurobiology. 23: 57-61. PMID 22878161 DOI: 10.1016/j.conb.2012.07.005 |
0.337 |
|
| 2012 |
Goodson M, Rust MB, Witke W, Bannerman D, Mott R, Ponting CP, Flint J. Cofilin-1: a modulator of anxiety in mice. Plos Genetics. 8: e1002970. PMID 23055942 DOI: 10.1371/Journal.Pgen.1002970 |
0.348 |
|
| 2012 |
Flint J, Eskin E. Genome-wide association studies in mice. Nature Reviews. Genetics. 13: 807-17. PMID 23044826 DOI: 10.1038/Nrg3335 |
0.334 |
|
| 2011 |
Yalcin B, Wong K, Agam A, Goodson M, Keane TM, Gan X, Nellåker C, Goodstadt L, Nicod J, Bhomra A, Hernandez-Pliego P, Whitley H, Cleak J, Dutton R, Janowitz D, ... ... Flint J, et al. Sequence-based characterization of structural variation in the mouse genome. Nature. 477: 326-9. PMID 21921916 DOI: 10.1038/Nature10432 |
0.336 |
|
| 2011 |
Keane TM, Goodstadt L, Danecek P, White MA, Wong K, Yalcin B, Heger A, Agam A, Slater G, Goodson M, Furlotte NA, Eskin E, Nellåker C, Whitley H, Cleak J, ... ... Flint J, et al. Mouse genomic variation and its effect on phenotypes and gene regulation. Nature. 477: 289-94. PMID 21921910 DOI: 10.1038/Nature10413 |
0.329 |
|
| 2011 |
Hettema JM, Webb BT, Guo AY, Zhao Z, Maher BS, Chen X, An SS, Sun C, Aggen SH, Kendler KS, Kuo PH, Otowa T, Flint J, van den Oord EJ. Prioritization and association analysis of murine-derived candidate genes in anxiety-spectrum disorders. Biological Psychiatry. 70: 888-96. PMID 21871609 DOI: 10.1016/J.Biopsych.2011.07.012 |
0.359 |
|
| 2011 |
Ahlqvist E, Ekman D, Lindvall T, Popovic M, Förster M, Hultqvist M, Klaczkowska D, Teneva I, Johannesson M, Flint J, Valdar W, Nandakumar KS, Holmdahl R. High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice Human Molecular Genetics. 20: 3031-3041. PMID 21565963 DOI: 10.1093/Hmg/Ddr206 |
0.348 |
|
| 2011 |
Johnsen AK, Valdar W, Golden L, Ortiz-Lopez A, Hitzemann R, Flint J, Mathis D, Benoist C. Genome-wide and species-wide dissection of the genetics of arthritis severity in heterogeneous stock mice. Arthritis and Rheumatism. 63: 2630-40. PMID 21560115 DOI: 10.1002/Art.30425 |
0.333 |
|
| 2011 |
Flint J. Mapping quantitative traits and strategies to find quantitative trait genes Methods. 53: 163-174. PMID 20643209 DOI: 10.1016/j.ymeth.2010.07.007 |
0.317 |
|
| 2010 |
Yalcin B, Nicod J, Bhomra A, Davidson S, Cleak J, Farinelli L, Østerås M, Whitley A, Yuan W, Gan X, Goodson M, Klenerman P, Satpathy A, Mathis D, Benoist C, ... ... Flint J, et al. Commercially available outbred mice for genome-wide association studies. Plos Genetics. 6: e1001085. PMID 20838427 DOI: 10.1371/Journal.Pgen.1001085 |
0.392 |
|
| 2009 |
Cox A, Ackert-Bicknell CL, Dumont BL, Ding Y, Bell JT, Brockmann GA, Wergedal JE, Bult C, Paigen B, Flint J, Tsaih SW, Churchill GA, Broman KW. A new standard genetic map for the laboratory mouse. Genetics. 182: 1335-44. PMID 19535546 DOI: 10.1534/Genetics.109.105486 |
0.355 |
|
| 2009 |
Flint J, Mackay TF. Genetic architecture of quantitative traits in mice, flies, and humans. Genome Research. 19: 723-33. PMID 19411597 DOI: 10.1101/gr.086660.108 |
0.419 |
|
| 2009 |
Huang GJ, Shifman S, Valdar W, Johannesson M, Yalcin B, Taylor MS, Taylor JM, Mott R, Flint J. High resolution mapping of expression QTLs in heterogeneous stock mice in multiple tissues. Genome Research. 19: 1133-40. PMID 19376938 DOI: 10.1101/Gr.088120.108 |
0.403 |
|
| 2009 |
Johannesson M, Lopez-Aumatell R, Stridh P, Diez M, Tuncel J, Blázquez G, Martinez-Membrives E, Cañete T, Vicens-Costa E, Graham D, Copley RR, Hernandez-Pliego P, Beyeen AD, Ockinger J, Fernández-SantamarÃa C, ... ... Flint J, et al. A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: the NIH heterogeneous stock. Genome Research. 19: 150-8. PMID 18971309 DOI: 10.1101/Gr.081497.108 |
0.356 |
|
| 2008 |
Flint J, Mott R. Applying mouse complex-trait resources to behavioural genetics. Nature. 456: 724-7. PMID 19079048 DOI: 10.1038/Nature07630 |
0.301 |
|
| 2008 |
Flint J, Shifman S, Munafo M, Mott R. Genetic variants in major depression. Novartis Foundation Symposium. 289: 23-32; discussion 33. PMID 18497093 DOI: 10.1002/9780470751251.Ch3 |
0.337 |
|
| 2008 |
Mott R, Flint J. Prospects for complex trait analysis in the mouse. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 19: 306-8. PMID 18493822 DOI: 10.1007/S00335-008-9110-4 |
0.377 |
|
| 2008 |
Fullerton JM, Willis-Owen SA, Yalcin B, Shifman S, Copley RR, Miller SR, Bhomra A, Davidson S, Oliver PL, Mott R, Flint J. Human-mouse quantitative trait locus concordance and the dissection of a human neuroticism locus. Biological Psychiatry. 63: 874-83. PMID 18083140 DOI: 10.1016/J.Biopsych.2007.10.019 |
0.588 |
|
| 2006 |
Shifman S, Bell JT, Copley RR, Taylor MS, Williams RW, Mott R, Flint J. A high-resolution single nucleotide polymorphism genetic map of the mouse genome. Plos Biology. 4: e395. PMID 17105354 DOI: 10.1371/Journal.Pbio.0040395 |
0.369 |
|
| 2006 |
Valdar W, Solberg LC, Gauguier D, Cookson WO, Rawlins JN, Mott R, Flint J. Genetic and environmental effects on complex traits in mice. Genetics. 174: 959-84. PMID 16888333 DOI: 10.1534/Genetics.106.060004 |
0.342 |
|
| 2006 |
Valdar W, Solberg LC, Gauguier D, Burnett S, Klenerman P, Cookson WO, Taylor MS, Rawlins JN, Mott R, Flint J. Genome-wide genetic association of complex traits in heterogeneous stock mice. Nature Genetics. 38: 879-87. PMID 16832355 DOI: 10.1038/Ng1840 |
0.43 |
|
| 2006 |
Aitman TJ, Dong R, Vyse TJ, Norsworthy PJ, Johnson MD, Smith J, Mangion J, Roberton-Lowe C, Marshall AJ, Petretto E, Hodges MD, Bhangal G, Patel SG, Sheehan-Rooney K, Duda M, ... ... Flint J, et al. Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans. Nature. 439: 851-5. PMID 16482158 DOI: 10.1038/nature04489 |
0.301 |
|
| 2006 |
Solberg LC, Valdar W, Gauguier D, Nunez G, Taylor A, Burnett S, Arboledas-Hita C, Hernandez-Pliego P, Davidson S, Burns P, Bhattacharya S, Hough T, Higgs D, Klenerman P, Cookson WO, ... ... Flint J, et al. A protocol for high-throughput phenotyping, suitable for quantitative trait analysis in mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 17: 129-46. PMID 16465593 DOI: 10.1007/S00335-005-0112-1 |
0.396 |
|
| 2005 |
Willis-Owen SA, Fullerton J, Surtees PG, Wainwright NW, Miller S, Flint J. The Val66Met coding variant of the brain-derived neurotrophic factor (BDNF) gene does not contribute toward variation in the personality trait neuroticism. Biological Psychiatry. 58: 738-42. PMID 16043130 DOI: 10.1016/j.biopsych.2005.05.014 |
0.514 |
|
| 2005 |
Flint J, Valdar W, Shifman S, Mott R. Strategies for mapping and cloning quantitative trait genes in rodents. Nature Reviews. Genetics. 6: 271-86. PMID 15803197 DOI: 10.1038/Nrg1576 |
0.347 |
|
| 2005 |
Khoo JP, Nicoli T, Alp NJ, Fullerton J, Flint J, Channon KM. Congenic mapping and genotyping of the tetrahydrobiopterin-deficient hph-1 mouse. Molecular Genetics and Metabolism. 82: 251-4. PMID 15234340 DOI: 10.1016/J.YMGME.2004.04.006 |
0.512 |
|
| 2004 |
Yalcin B, Willis-Owen SA, Fullerton J, Meesaq A, Deacon RM, Rawlins JN, Copley RR, Morris AP, Flint J, Mott R. Genetic dissection of a behavioral quantitative trait locus shows that Rgs2 modulates anxiety in mice. Nature Genetics. 36: 1197-202. PMID 15489855 DOI: 10.1038/Ng1450 |
0.584 |
|
| 2004 |
Flint J. The genetic basis of neuroticism Neuroscience and Biobehavioral Reviews. 28: 307-316. PMID 15225973 DOI: 10.1016/j.neubiorev.2004.01.004 |
0.368 |
|
| 2004 |
Flint J, DeFries JC, Henderson ND. Little epistasis for anxiety-related measures in the DeFries strains of laboratory mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 15: 77-82. PMID 15058379 DOI: 10.1007/S00335-003-3033-X |
0.338 |
|
| 2004 |
Turri MG, DeFries JC, Henderson ND, Flint J. Multivariate analysis of quantitative trait loci influencing variation in anxiety-related behavior in laboratory mice. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 15: 69-76. PMID 15058378 DOI: 10.1007/S00335-003-3032-Y |
0.373 |
|
| 2004 |
Henderson ND, Turri MG, DeFries JC, Flint J. QTL analysis of multiple behavioral measures of anxiety in mice. Behavior Genetics. 34: 267-93. PMID 14990867 DOI: 10.1023/B:Bege.0000017872.25069.44 |
0.318 |
|
| 2003 |
Valdar WS, Flint J, Mott R. QTL fine-mapping with recombinant-inbred heterogeneous stocks and in vitro heterogeneous stocks. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 14: 830-8. PMID 14724734 DOI: 10.1007/S00335-003-3021-1 |
0.314 |
|
| 2003 |
Hitzemann R, Malmanger B, Reed C, Lawler M, Hitzemann B, Coulombe S, Buck K, Rademacher B, Walter N, Polyakov Y, Sikela J, Gensler B, Burgers S, Williams RW, Manly K, ... Flint J, et al. A strategy for the integration of QTL, gene expression, and sequence analyses. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 14: 733-47. PMID 14722723 DOI: 10.1007/S00335-003-2277-9 |
0.345 |
|
| 2003 |
Abiola O, Angel JM, Avner P, Bachmanov AA, Belknap JK, Bennett B, Blankenhorn EP, Blizard DA, Bolivar V, Brockmann GA, Buck KJ, Bureau JF, Casley WL, Chesler EJ, Cheverud JM, ... ... Flint J, et al. The nature and identification of quantitative trait loci: a community's view. Nature Reviews. Genetics. 4: 911-6. PMID 14634638 DOI: 10.1038/Nrg1206 |
0.336 |
|
| 2003 |
Talbot CJ, Radcliffe RA, Fullerton J, Hitzemann R, Wehner JM, Flint J. Fine scale mapping of a genetic locus for conditioned fear. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 14: 223-30. PMID 12682774 DOI: 10.1007/S00335-002-3059-5 |
0.58 |
|
| 2003 |
Steinberger D, Reynolds DS, Ferris P, Lincoln R, Datta S, Stanley J, Paterson A, Dawson GR, Flint J. Genetic mapping of variation in spatial learning in the mouse Journal of Neuroscience. 23: 2426-2433. PMID 12657702 |
0.35 |
|
| 2003 |
Fullerton J, Cubin M, Tiwari H, Wang C, Bomhra A, Davidson S, Miller S, Fairburn C, Goodwin G, Neale MC, Fiddy S, Mott R, Allison DB, Flint J. Linkage analysis of extremely discordant and concordant sibling pairs identifies quantitative-trait loci that influence variation in the human personality trait neuroticism. American Journal of Human Genetics. 72: 879-90. PMID 12612864 DOI: 10.1086/374178 |
0.574 |
|
| 2003 |
Flint J. Animal models of anxiety and their molecular dissection Seminars in Cell and Developmental Biology. 14: 37-42. PMID 12524005 DOI: 10.1016/S1084-9521(02)00170-2 |
0.305 |
|
| 2003 |
Flint J. Analysis of quantitative trait loci that influence animal behavior Journal of Neurobiology. 54: 46-77. PMID 12486698 DOI: 10.1002/neu.10161 |
0.373 |
|
| 2002 |
Flint J. Genetic effects on an animal model of anxiety Febs Letters. 529: 131-134. PMID 12354625 DOI: 10.1016/S0014-5793(02)03190-3 |
0.356 |
|
| 2002 |
Mott R, Flint J. Simultaneous detection and fine mapping of quantitative trait loci in mice using heterogeneous stocks. Genetics. 160: 1609-18. PMID 11973314 DOI: 10.1093/genetics/160.4.1609 |
0.354 |
|
| 2002 |
Fernández-Teruel A, Escorihuela RM, Gray JA, Aguilar R, Gil L, Giménez-Llort L, Tobeña A, Bhomra A, Nicod A, Mott R, Driscoll P, Dawson GR, Flint J. A quantitative trait locus influencing anxiety in the laboratory rat. Genome Research. 12: 618-26. PMID 11932246 DOI: 10.1101/Gr.203402 |
0.375 |
|
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