| Year |
Citation |
Score |
| 2024 |
Smith K, Deutsch AJ, McGrail C, Kim H, Hsu S, Huerta-Chagoya A, Mandla R, Schroeder PH, Westerman KE, Szczerbinski L, Majarian TD, Kaur V, Williamson A, Zaitlen N, Claussnitzer M, ... ... Manning AK, et al. Multi-ancestry polygenic mechanisms of type 2 diabetes. Nature Medicine. PMID 38443691 DOI: 10.1038/s41591-024-02865-3 |
0.304 |
|
| 2023 |
Smith K, Deutsch AJ, McGrail C, Kim H, Hsu S, Mandla R, Schroeder PH, Westerman KE, Szczerbinski L, Majarian TD, Kaur V, Williamson A, Claussnitzer M, Florez JC, Manning AK, et al. Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity. Research Square. PMID 37886436 DOI: 10.21203/rs.3.rs-3399145/v1 |
0.31 |
|
| 2023 |
Smith K, Deutsch AJ, McGrail C, Kim H, Hsu S, Mandla R, Schroeder PH, Westerman KE, Szczerbinski L, Majarian TD, Kaur V, Williamson A, Claussnitzer M, Florez JC, Manning AK, et al. Multi-ancestry Polygenic Mechanisms of Type 2 Diabetes Elucidate Disease Processes and Clinical Heterogeneity. Medrxiv : the Preprint Server For Health Sciences. PMID 37808749 DOI: 10.1101/2023.09.28.23296294 |
0.31 |
|
| 2023 |
Schroeder P, Mandla R, Huerta-Chagoya A, Alkanak A, Nagy D, Szczerbinski L, Madsen JGS, Cole JB, Porneala B, Westerman K, Li JH, Pollin TI, Florez JC, Gloyn AL, Cebola I, ... Manning A, et al. Rare variant association analysis in 51,256 type 2 diabetes cases and 370,487 controls informs the spectrum of pathogenicity of monogenic diabetes genes. Medrxiv : the Preprint Server For Health Sciences. PMID 37808701 DOI: 10.1101/2023.09.28.23296244 |
0.406 |
|
| 2023 |
Manning A, Sevilla-González M, Smith K, Wang N, Jensen A, Litkowski E, Kim H, DiCorpo D, Westerman K, Cui J, Liu CT, Yu C, McNeil J, Lacaze P, Chang KM, et al. Heterogeneous effects on type 2 diabetes and cardiovascular outcomes of genetic variants and traits associated with fasting insulin. Research Square. PMID 37790568 DOI: 10.21203/rs.3.rs-3317661/v1 |
0.301 |
|
| 2023 |
Huerta-Chagoya A, Schroeder P, Mandla R, Deutsch AJ, Zhu W, Petty L, Yi X, Cole JB, Udler MS, Dornbos P, Porneala B, DiCorpo D, Liu CT, Li JH, Szczerbiński L, ... ... Manning A, et al. The power of TOPMed imputation for the discovery of Latino-enriched rare variants associated with type 2 diabetes. Diabetologia. PMID 37148359 DOI: 10.1007/s00125-023-05912-9 |
0.358 |
|
| 2023 |
Westerman KE, Walker ME, Gaynor SM, Wesse J, DiCorpo D, Ma J, Alonso A, Aslibekyan S, Baldridge AS, Bertoni AG, Biggs ML, Brody JA, Chen YI, Dupuis J, Goodarzi MO, ... ... Manning AK, et al. Investigating gene-diet interactions impacting the association between macronutrient intake and glycemic traits. Diabetes. PMID 36791419 DOI: 10.2337/db22-0851 |
0.402 |
|
| 2022 |
Li Z, Li X, Zhou H, Gaynor SM, Selvaraj MS, Arapoglou T, Quick C, Liu Y, Chen H, Sun R, Dey R, Arnett DK, Auer PL, Bielak LF, Bis JC, ... ... Manning AK, et al. A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies. Nature Methods. PMID 36303018 DOI: 10.1038/s41592-022-01640-x |
0.352 |
|
| 2022 |
DiCorpo D, Gaynor SM, Russell EM, Westerman KE, Raffield LM, Majarian TD, Wu P, Sarnowski C, Highland HM, Jackson A, Hasbani NR, de Vries PS, Brody JA, Hidalgo B, Guo X, ... ... Manning AK, et al. Whole genome sequence association analysis of fasting glucose and fasting insulin levels in diverse cohorts from the NHLBI TOPMed program. Communications Biology. 5: 756. PMID 35902682 DOI: 10.1038/s42003-022-03702-4 |
0.386 |
|
| 2022 |
Westerman KE, Majarian TD, Giulianini F, Jang DK, Miao J, Florez JC, Chen H, Chasman DI, Udler MS, Manning AK, Cole JB. Variance-quantitative trait loci enable systematic discovery of gene-environment interactions for cardiometabolic serum biomarkers. Nature Communications. 13: 3993. PMID 35810165 DOI: 10.1038/s41467-022-31625-5 |
0.347 |
|
| 2022 |
Gaynor SM, Westerman KE, Ackovic LL, Li X, Li Z, Manning AK, Philippakis A, Lin X. STAAR Workflow: A cloud-based workflow for scalable and reproducible rare variant analysis. Bioinformatics (Oxford, England). PMID 35441669 DOI: 10.1093/bioinformatics/btac272 |
0.3 |
|
| 2022 |
Westerman KE, Lin J, Sevilla-Gonzalez MDR, Tadess B, Marchek C, Manning AK. Gene-Environment Interaction Analysis Incorporating Sex, Cardiometabolic Diseases, and Multiple Deprivation Index Reveals Novel Genetic Associations With COVID-19 Severity. Frontiers in Genetics. 12: 782172. PMID 35096005 DOI: 10.3389/fgene.2021.782172 |
0.35 |
|
| 2021 |
Westerman KE, Lin J, Sevilla-Gonzalez M, Tadess B, Marchek C, Manning AK. Gene-environment interaction analysis incorporating sex, cardiometabolic diseases, and multiple deprivation index reveals novel genetic associations with COVID-19 severity. Medrxiv : the Preprint Server For Health Sciences. PMID 34462758 DOI: 10.1101/2021.08.13.21261910 |
0.353 |
|
| 2021 |
Westerman KE, Miao J, Chasman DI, Florez JC, Chen H, Manning AK, Cole JB. Genome-wide gene-diet interaction analysis in the UK Biobank identifies novel effects on Hemoglobin A1c. Human Molecular Genetics. PMID 33864366 DOI: 10.1093/hmg/ddab109 |
0.388 |
|
| 2021 |
Taliun D, Harris DN, Kessler MD, Carlson J, Szpiech ZA, Torres R, Taliun SAG, Corvelo A, Gogarten SM, Kang HM, Pitsillides AN, LeFaive J, Lee SB, Tian X, Browning BL, ... ... Manning AK, et al. Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program. Nature. 590: 290-299. PMID 33568819 DOI: 10.1038/s41586-021-03205-y |
0.354 |
|
| 2021 |
Srinivasan S, Chen L, Todd J, Divers J, Gidding S, Chernausek S, Gubitosi-Klug RA, Kelsey MM, Shah R, Black MH, Wagenknecht LE, Manning A, Flannick J, Imperatore G, Mercader JM, et al. The First Genome-Wide Association Study for Type 2 Diabetes in Youth: The Progress in Diabetes Genetics in Youth (ProDiGY) Consortium. Diabetes. PMID 33479058 DOI: 10.2337/db20-0443 |
0.378 |
|
| 2020 |
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B, Yao C, Kraja AT, Cartwright JH, Hellwege JN, Giri A, Tragante V, Thorleifsson G, ... ... Manning AK, et al. Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics. PMID 33230300 DOI: 10.1038/s41588-020-00713-x |
0.381 |
|
| 2020 |
Wang X, Lim E, Liu CT, Sung YJ, Rao DC, Morrison AC, Boerwinkle E, Manning AK, Chen H. Efficient gene-environment interaction tests for large biobank-scale sequencing studies. Genetic Epidemiology. PMID 32864785 DOI: 10.1002/Gepi.22351 |
0.432 |
|
| 2020 |
Manning AK, Goustin AS, Kleinbrink EL, Thepsuwan P, Cai J, Ju D, Leong A, Udler MS, Brown JB, Goodarzi MO, Rotter JI, Sladek R, Meigs JB, Lipovich L. A Long Non-coding RNA, , Is an Effector Transcript at the Chromosome 8p23.1- Metabolic Traits and Type 2 Diabetes Risk Locus. Frontiers in Genetics. 11: 615. PMID 32754192 DOI: 10.3389/Fgene.2020.00615 |
0.43 |
|
| 2020 |
Laville V, Majarian T, de Vries PS, Bentley AR, Feitosa MF, Sung YJ, Rao DC, Manning A, Aschard H. Deriving stratified effects from joint models investigating gene-environment interactions. Bmc Bioinformatics. 21: 251. PMID 32552674 DOI: 10.1186/S12859-020-03569-4 |
0.314 |
|
| 2020 |
de Las Fuentes L, Sung YJ, Noordam R, Winkler T, Feitosa MF, Schwander K, Bentley AR, Brown MR, Guo X, Manning A, Chasman DI, Aschard H, Bartz TM, Bielak LF, Campbell A, et al. Gene-educational attainment interactions in a multi-ancestry genome-wide meta-analysis identify novel blood pressure loci. Molecular Psychiatry. PMID 32372009 DOI: 10.1038/S41380-020-0719-3 |
0.409 |
|
| 2020 |
Manning A. 242-OR: Rare Genetic Variants in the Islet Regulome Contribute to the Heritability of Type 2 Diabetes Risk Diabetes. 69. DOI: 10.2337/Db20-242-Or |
0.415 |
|
| 2020 |
Powe CE, Udler M, Hsu S, Kuang A, Allard C, Manning A, Bouchard L, Perron P, Florez JC, Lowe W, Scholtens D, Hivert M. 193-OR: Physiology-Informed Type 2 Diabetes Genetic Clusters and Gestational Diabetes Diabetes. 69. DOI: 10.2337/Db20-193-Or |
0.422 |
|
| 2020 |
Sevilla M, Udler M, Kim H, Hsu S, Meigs JB, Manning A. 1649-P: Effect of Fasting Insulin-Derived Gene Variant Clusters on Cardiometabolic Traits Diabetes. 69. DOI: 10.2337/Db20-1649-P |
0.359 |
|
| 2020 |
Kim H, Grotthuss MV, Mercader JM, Chiou J, Gaulton KJ, Manning A, Florez JC, Udler M. 1644-P: High Throughput Approach Enables Expanded Clustering of Type 2 Diabetes Genetic Loci Informed by Phenotypic Associations Diabetes. 69. DOI: 10.2337/Db20-1644-P |
0.428 |
|
| 2019 |
Noordam R, Bos MM, Wang H, Winkler TW, Bentley AR, Kilpeläinen TO, de Vries PS, Sung YJ, Schwander K, Cade BE, Manning A, Aschard H, Brown MR, Chen H, Franceschini N, et al. Multi-ancestry sleep-by-SNP interaction analysis in 126,926 individuals reveals lipid loci stratified by sleep duration. Nature Communications. 10: 5121. PMID 31719535 DOI: 10.1038/S41467-019-12958-0 |
0.324 |
|
| 2019 |
Sarnowski C, Leong A, Raffield LM, Wu P, de Vries PS, DiCorpo D, Guo X, Xu H, Liu Y, Zheng X, Hu Y, Brody JA, Goodarzi MO, Hidalgo BA, Highland HM, ... ... Manning AK, et al. Impact of Rare and Common Genetic Variants on Diabetes Diagnosis by Hemoglobin A1c in Multi-Ancestry Cohorts: The Trans-Omics for Precision Medicine Program. American Journal of Human Genetics. PMID 31564435 DOI: 10.1016/J.Ajhg.2019.08.010 |
0.473 |
|
| 2019 |
Sung YJ, de Las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR, Guo X, Schwander K, Manning AK, Brown MR, Aschard H, Feitosa MF, Franceschini N, et al. A multi-ancestry genome-wide study incorporating gene-smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure. Human Molecular Genetics. PMID 31127295 DOI: 10.1093/Hmg/Ddz070 |
0.384 |
|
| 2019 |
Flannick J, Mercader JM, Fuchsberger C, Udler MS, Mahajan A, Wessel J, Teslovich TM, Caulkins L, Koesterer R, Barajas-Olmos F, Blackwell TW, Boerwinkle E, Brody JA, Centeno-Cruz F, Chen L, ... ... Manning AK, et al. Exome sequencing of 20,791 cases of type 2 diabetes and 24,440 controls. Nature. PMID 31118516 DOI: 10.1038/s41586-019-1231-2 |
0.392 |
|
| 2019 |
Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, Schwander K, Chasman DI, Lim E, Deng X, Guo X, Liu J, Lu Y, Cheng CY, Sim X, ... ... Manning AK, et al. Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. Nature Genetics. 51: 636-648. PMID 30926973 DOI: 10.1038/S41588-019-0378-Y |
0.395 |
|
| 2019 |
Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL, Fine RS, Guo X, Schurmann C, Lempradl A, Marouli E, Mahajan A, Winkler TW, ... ... Manning AK, et al. Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution. Nature Genetics. PMID 30778226 DOI: 10.1038/S41588-018-0334-2 |
0.404 |
|
| 2019 |
de Vries PS, Brown MR, Bentley AR, Sung YJ, Winkler TW, Ntalla I, Schwander K, Kraja AT, Guo X, Franceschini N, Cheng CY, Sim X, Vojinovic D, Huffman JE, Musani SK, ... ... Manning AK, et al. Multi-Ancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions. American Journal of Epidemiology. PMID 30698716 DOI: 10.1093/Aje/Kwz005 |
0.428 |
|
| 2019 |
Kilpeläinen TO, Bentley AR, Noordam R, Sung YJ, Schwander K, Winkler TW, Jakupović H, Chasman DI, Manning A, Ntalla I, Aschard H, Brown MR, de Las Fuentes L, Franceschini N, Guo X, et al. Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity. Nature Communications. 10: 376. PMID 30670697 DOI: 10.1038/S41467-018-08008-W |
0.382 |
|
| 2019 |
Highland HM, Wessel J, Manning A. 30-OR: Whole Genome Sequence Analysis of Type 2 Diabetes Risk in 44,713 Humans of Diverse Ancestry in the TOPMed Study Diabetes. 68. DOI: 10.2337/Db19-30-Or |
0.494 |
|
| 2019 |
Szeto MD, Highland HM, Manning A. 1722-P: Colocalization of TOPMed Whole Genome Sequencing Analysis and Tissue-Specific eQTL Signals Detects Target Genes for Type 2 Diabetes Risk Diabetes. 68. DOI: 10.2337/Db19-1722-P |
0.45 |
|
| 2018 |
Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N, Cheng CY, Sim X, Vojinovic D, Marten J, Musani SK, Li C, Bentley AR, ... ... Manning AK, et al. Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. Plos One. 13: e0198166. PMID 29912962 DOI: 10.1371/Journal.Pone.0198166 |
0.397 |
|
| 2018 |
Sung YJ, Winkler TW, de Las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I, Guo X, Franceschini N, Lu Y, Cheng CY, Sim X, Vojinovic D, Marten J, ... ... Manning AK, et al. A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure. American Journal of Human Genetics. PMID 29455858 DOI: 10.1016/J.Ajhg.2018.01.015 |
0.456 |
|
| 2018 |
Srinivasan S, Kaur V, Chamarthi B, Littleton KR, Chen L, Manning AK, Merino J, Thomas MK, Hudson M, Goldfine A, Florez JC. TCF7L2 Genetic Variation Augments Incretin Resistance and Influences Response to a Sulfonylurea and Metformin: The Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans (SUGAR-MGH). Diabetes Care. PMID 29326107 DOI: 10.2337/Dc17-1386 |
0.442 |
|
| 2018 |
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T, Giri A, Graff M, Guo X, Hendricks AE, Karaderi T, Lempradl A, Locke AE, ... ... Manning AK, et al. Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics. 50: 26-41. PMID 29273807 DOI: 10.1038/S41588-017-0011-X |
0.449 |
|
| 2018 |
Wessel J, Brody JA, Manning A. Whole Genome Sequence Association Analysis and Diabetes-centric Functional Annotation of Type 2 Diabetes Diabetes. 67. DOI: 10.2337/Db18-24-Or |
0.378 |
|
| 2018 |
Manning A, Majarian T, Vries PSD, Wessel J, Meigs JB. TOPMed Whole Genome Sequence Combined with Pancreas-Specific Annotation for Rare Variants Tests of Type 2 Diabetes Risk Diabetes. 67. DOI: 10.2337/Db18-1724-P |
0.444 |
|
| 2017 |
Jun G, Manning A, Almeida M, Zawistowski M, Wood AR, Teslovich TM, Fuchsberger C, Feng S, Cingolani P, Gaulton KJ, Dyer T, Blackwell TW, Chen H, Chines PS, Choi S, et al. Evaluating the contribution of rare variants to type 2 diabetes and related traits using pedigrees. Proceedings of the National Academy of Sciences of the United States of America. PMID 29279374 DOI: 10.1073/Pnas.1705859115 |
0.504 |
|
| 2017 |
Jason F, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R, Ma C, Moutsianas L, McCarthy DJ, Rivas MA, Perry JRB, Sim X, Blackwell TW, ... ... Manning A, et al. Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. Scientific Data. 4: 170179. PMID 29257133 DOI: 10.1038/Sdata.2017.179 |
0.483 |
|
| 2017 |
Latva-Rasku A, Honka MJ, Stančáková A, Koistinen HA, Kuusisto J, Guan L, Manning AK, Stringham H, Gloyn AL, Lindgren CM, Collins FS, Mohlke KL, Scott LJ, Karjalainen T, et al. A Partial Loss-of-Function Variant in AKT2 is Associated with Reduced Insulin-Mediated Glucose Uptake in Multiple Insulin Sensitive Tissues: a Genotype-Based Callback Positron Emission Tomography Study. Diabetes. PMID 29141982 DOI: 10.2337/Db17-1142 |
0.395 |
|
| 2017 |
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C, Alam D, Alves AC, Amouyel P, Di Angelantonio E, Arveiler D, Assimes TL, Auer PL, ... ... Manning AK, et al. Exome-wide association study of plasma lipids in >300,000 individuals. Nature Genetics. PMID 29083408 DOI: 10.1038/Ng.3977 |
0.411 |
|
| 2017 |
Brody JA, Morrison AC, Bis JC, O'Connell JR, Brown MR, Huffman JE, Ames DC, Carroll A, Conomos MP, Gabriel S, Gibbs RA, Gogarten SM, Gupta N, Jaquish CE, Johnson AD, ... ... Manning AK, et al. Analysis commons, a team approach to discovery in a big-data environment for genetic epidemiology. Nature Genetics. 49: 1560-1563. PMID 29074945 DOI: 10.1038/Ng.3968 |
0.331 |
|
| 2017 |
Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N, Drenos F, Sim X, Smith AV, Amin N, Blakemore AIF, Bork-Jensen J, Brandslund I, et al. New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals. Circulation. Cardiovascular Genetics. 10. PMID 29030403 DOI: 10.1161/Circgenetics.117.001778 |
0.456 |
|
| 2017 |
Tachmazidou I, Süveges D, Min JL, Ritchie GRS, Steinberg J, Walter K, Iotchkova V, Schwartzentruber J, Huang J, Memari Y, McCarthy S, Crawford AA, Bombieri C, Cocca M, Farmaki AE, ... ... Manning AK, et al. Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits. American Journal of Human Genetics. PMID 28552196 DOI: 10.1016/J.Ajhg.2017.04.014 |
0.42 |
|
| 2017 |
Billings LK, Jablonski KA, Warner AS, Cheng YC, McAteer JB, Tipton L, Shuldiner AR, Ehrmann DA, Manning AK, Dabelea D, Franks PW, Kahn SE, Pollin TI, Knowler WC, Altshuler D, et al. Variation in Maturity-Onset Diabetes of the Young genes influence response to interventions for diabetes prevention. The Journal of Clinical Endocrinology and Metabolism. PMID 28453780 DOI: 10.1210/Jc.2016-3429 |
0.348 |
|
| 2017 |
Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA, Mahajan A, Locke AE, Cingolani P, Pers TH, Viñuela A, Brown AA, Wu Y, et al. A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk. Diabetes. PMID 28341696 DOI: 10.2337/Db16-1329 |
0.488 |
|
| 2017 |
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y, Schurmann C, Highland HM, Rüeger S, Thorleifsson G, Justice AE, Lamparter D, Stirrups KE, ... ... Manning AK, et al. Rare and low-frequency coding variants alter human adult height. Nature. PMID 28146470 DOI: 10.1038/Nature21039 |
0.479 |
|
| 2016 |
Almeida M, Blondell L, Peralta JM, Kent JW, Jun G, Teslovich TM, Fuchsberger C, Wood AR, Manning AK, Frayling TM, Cingolani PE, Sladek R, Dyer TD, Abecasis G, Duggirala R, et al. Independent test assessment using the extreme value distribution theory. Bmc Proceedings. 10: 245-249. PMID 27980644 DOI: 10.1186/S12919-016-0038-5 |
0.476 |
|
| 2016 |
Blangero J, Teslovich TM, Sim X, Almeida MA, Jun G, Dyer TD, Johnson M, Peralta JM, Manning A, Wood AR, Fuchsberger C, Kent JW, Aguilar DA, Below JE, Farook VS, et al. Omics-squared: human genomic, transcriptomic and phenotypic data for genetic analysis workshop 19. Bmc Proceedings. 10: 71-77. PMID 27980614 DOI: 10.1186/S12919-016-0008-Y |
0.379 |
|
| 2016 |
Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, et al. Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nature Genetics. PMID 27618447 DOI: 10.1038/Ng.3654 |
0.408 |
|
| 2016 |
Walford GA, Gustafsson S, Rybin D, Stančáková A, Chen H, Liu CT, Hong J, Jensen RA, Rice K, Morris AP, Mägi R, Tönjes A, Prokopenko I, Kleber ME, Delgado G, ... ... Manning AK, et al. Genome-wide association study of the modified Stumvoll Insulin Sensitivity Index identifies BCL2 and FAM19A2 as novel insulin sensitivity loci. Diabetes. PMID 27416945 DOI: 10.2337/Db16-0199 |
0.468 |
|
| 2016 |
Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P, Moutsianas L, McCarthy DJ, Rivas MA, Perry JR, Sim X, Blackwell TW, Robertson NR, ... ... Manning A, et al. The genetic architecture of type 2 diabetes. Nature. PMID 27398621 DOI: 10.1038/Nature18642 |
0.494 |
|
| 2016 |
Nicholson AM, Finch NA, Almeida M, Perkerson RB, van Blitterswijk M, Wojtas A, Cenik B, Rotondo S, Inskeep V, Almasy L, Dyer T, Peralta J, Jun G, Wood AR, Frayling TM, ... ... Manning AK, et al. Prosaposin is a regulator of progranulin levels and oligomerization. Nature Communications. 7: 11992. PMID 27356620 DOI: 10.1038/Ncomms11992 |
0.343 |
|
| 2016 |
Sung YJ, Winkler TW, Manning AK, Aschard H, Gudnason V, Harris TB, Smith AV, Boerwinkle E, Brown MR, Morrison AC, Fornage M, Lin LA, Richard M, Bartz TM, Psaty BM, et al. An Empirical Comparison of Joint and Stratified Frameworks for Studying G × E Interactions: Systolic Blood Pressure and Smoking in the CHARGE Gene-Lifestyle Interactions Working Group. Genetic Epidemiology. PMID 27230302 DOI: 10.1002/Gepi.21978 |
0.404 |
|
| 2016 |
Lessard S, Manning AK, Low-Kam C, Auer PL, Giri A, Graff M, Schurmann C, Yaghootkar H, Luan J, Esko T, Karaderi T, et al. Testing the Role of Predicted Gene Knockouts in Human Anthropometric Trait Variation. Human Molecular Genetics. PMID 26908616 DOI: 10.1093/Hmg/Ddw055 |
0.419 |
|
| 2016 |
Fadista J, Manning AK, Florez JC, Groop L. The (in)famous GWAS P-value threshold revisited and updated for low-frequency variants. European Journal of Human Genetics : Ejhg. PMID 26733288 DOI: 10.1038/Ejhg.2015.269 |
0.497 |
|
| 2015 |
Walford GA, Colomo N, Todd JN, Billings LK, Fernandez M, Chamarthi B, Warner AS, Davis J, Littleton KR, Hernandez AM, Fanelli RR, Lanier A, Barbato C, Ackerman RJ, Khan SQ, ... ... Manning AK, et al. The study to understand the genetics of the acute response to metformin and glipizide in humans (SUGAR-MGH): design of a pharmacogenetic resource for type 2 diabetes. Plos One. 10: e0121553. PMID 25812009 DOI: 10.1371/Journal.Pone.0121553 |
0.465 |
|
| 2015 |
Mahajan A, Sim X, Ng HJ, Manning A, Rivas MA, Highland HM, Locke AE, Grarup N, Im HK, Cingolani P, Flannick J, Fontanillas P, Fuchsberger C, Gaulton KJ, Teslovich TM, et al. Identification and functional characterization of G6PC2 coding variants influencing glycemic traits define an effector transcript at the G6PC2-ABCB11 locus. Plos Genetics. 11: e1004876. PMID 25625282 DOI: 10.1371/Journal.Pgen.1004876 |
0.518 |
|
| 2014 |
Lim ET, Würtz P, Havulinna AS, Palta P, Tukiainen T, Rehnström K, Esko T, Mägi R, Inouye M, Lappalainen T, Chan Y, Salem RM, Lek M, Flannick J, Sim X, ... Manning A, et al. Distribution and medical impact of loss-of-function variants in the Finnish founder population. Plos Genetics. 10: e1004494. PMID 25078778 DOI: 10.1371/Journal.Pgen.1004494 |
0.444 |
|
| 2014 |
Lange LA, Hu Y, Zhang H, Xue C, Schmidt EM, Tang ZZ, Bizon C, Lange EM, Smith JD, Turner EH, Jun G, Kang HM, Peloso G, Auer P, Li KP, ... ... Manning A, et al. Whole-exome sequencing identifies rare and low-frequency coding variants associated with LDL cholesterol. American Journal of Human Genetics. 94: 233-45. PMID 24507775 DOI: 10.1016/J.Ajhg.2014.01.010 |
0.472 |
|
| 2014 |
Jaiswal S, Fontanillas P, Flannick J, Manning A, Grauman P, Mar BG, Lindsley RC, Mermel C, Burtt N, Chavez A, Higgins JM, Moltchanov V, Kinnunen L, Koistinen H, Ladenvall C, et al. Clonal Hematopoiesis with Somatic Mutations Is a Common, Age-Related Condition Associated with Adverse Outcomes Blood. 124: 840-840. DOI: 10.1182/Blood.V124.21.840.840 |
0.383 |
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| 2012 |
Hancock DB, Artigas MS, Gharib SA, Henry A, Manichaikul A, Ramasamy A, Loth DW, Imboden M, Koch B, McArdle WL, Smith AV, Smolonska J, Sood A, Tang W, Wilk JB, ... ... Manning AK, et al. Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function. Plos Genetics. 8: e1003098. PMID 23284291 DOI: 10.1371/Journal.Pgen.1003098 |
0.424 |
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| 2012 |
Perry JR, Voight BF, Yengo L, Amin N, Dupuis J, Ganser M, Grallert H, Navarro P, Li M, Qi L, Steinthorsdottir V, Scott RA, Almgren P, Arking DE, Aulchenko Y, ... ... Manning AK, et al. Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases. Plos Genetics. 8: e1002741. PMID 22693455 DOI: 10.1371/Journal.Pgen.1002741 |
0.415 |
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| 2012 |
Manning AK, Hivert MF, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu CT, Bielak LF, Prokopenko I, Amin N, Barnes D, Cadby G, Hottenga JJ, Ingelsson E, et al. A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance. Nature Genetics. 44: 659-69. PMID 22581228 DOI: 10.1038/Ng.2274 |
0.469 |
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| 2012 |
Dastani Z, Hivert MF, Timpson N, Perry JR, Yuan X, Scott RA, Henneman P, Heid IM, Kizer JR, Lyytikäinen LP, Fuchsberger C, Tanaka T, Morris AP, Small K, Isaacs A, ... ... Manning AK, et al. Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals. Plos Genetics. 8: e1002607. PMID 22479202 DOI: 10.1371/Journal.Pgen.1002607 |
0.645 |
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| 2012 |
Scott RA, Chu AY, Grarup N, Manning AK, Hivert MF, Shungin D, Tönjes A, Yesupriya A, Barnes D, Bouatia-Naji N, Glazer NL, Jackson AU, Kutalik Z, Lagou V, Marek D, et al. No interactions between previously associated 2-hour glucose gene variants and physical activity or BMI on 2-hour glucose levels. Diabetes. 61: 1291-6. PMID 22415877 DOI: 10.2337/Db11-0973 |
0.458 |
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| 2012 |
Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN, Bostrom MA, Rudock ME, Talbert ME, Lewis JP, Ferrara A, ... ... Manning AK, et al. A genome-wide association search for type 2 diabetes genes in African Americans. Plos One. 7: e29202. PMID 22238593 DOI: 10.1371/Journal.Pone.0029202 |
0.51 |
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| 2011 |
Ngwa JS, Manning AK, Grimsby JL, Lu C, Zhuang WV, Destefano AL. Pathway analysis following association study. Bmc Proceedings. 5: S18. PMID 22373100 DOI: 10.1186/1753-6561-5-S9-S18 |
0.404 |
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| 2011 |
Khetarpal SA, Edmondson AC, Raghavan A, Neeli H, Jin W, Badellino KO, Demissie S, Manning AK, DerOhannessian SL, Wolfe ML, Cupples LA, Li M, Kathiresan S, Rader DJ. Mining the LIPG allelic spectrum reveals the contribution of rare and common regulatory variants to HDL cholesterol. Plos Genetics. 7: e1002393. PMID 22174694 DOI: 10.1371/Journal.Pgen.1002393 |
0.675 |
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| 2011 |
Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME, Bouatia-Naji N, Dimas AS, Nica A, Wheeler E, Chen H, Voight BF, Taneera J, ... ... Manning AK, et al. Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. Diabetes. 60: 2624-34. PMID 21873549 DOI: 10.2337/Db11-0415 |
0.521 |
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| 2011 |
de Miguel-Yanes JM, Manning AK, Shrader P, McAteer JB, Goel A, Hamsten A, Fox CS, Florez JC, Dupuis J, Meigs JB. Variants at the endocannabinoid receptor CB1 gene (CNR1) and insulin sensitivity, type 2 diabetes, and coronary heart disease. Obesity (Silver Spring, Md.). 19: 2031-7. PMID 21633404 DOI: 10.1038/Oby.2011.135 |
0.509 |
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| 2011 |
Manning AK, LaValley M, Liu CT, Rice K, An P, Liu Y, Miljkovic I, Rasmussen-Torvik L, Harris TB, Province MA, Borecki IB, Florez JC, Meigs JB, Cupples LA, Dupuis J. Meta-analysis of gene-environment interaction: joint estimation of SNP and SNP × environment regression coefficients. Genetic Epidemiology. 35: 11-8. PMID 21181894 DOI: 10.1002/Gepi.20546 |
0.491 |
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| 2011 |
de Miguel-Yanes JM, Shrader P, Pencina MJ, Fox CS, Manning AK, Grant RW, Dupuis J, Florez JC, D'Agostino RB, Cupples LA, Meigs JB. Genetic risk reclassification for type 2 diabetes by age below or above 50 years using 40 type 2 diabetes risk single nucleotide polymorphisms. Diabetes Care. 34: 121-5. PMID 20889853 DOI: 10.2337/Dc10-1265 |
0.424 |
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| 2010 |
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, ... ... Manning AK, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics. 42: 105-16. PMID 20081858 DOI: 10.1038/Ng.520 |
0.449 |
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| 2010 |
Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N, Dupuis J, Jackson AU, Kao WH, Li M, Glazer NL, Manning AK, Luan J, et al. Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. Nature Genetics. 42: 142-8. PMID 20081857 DOI: 10.1038/Ng.521 |
0.42 |
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| 2010 |
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL, Bouatia-Naji N, Gloyn AL, Lindgren CM, Mägi R, Morris AP, Randall J, Johnson T, ... ... Manning AK, et al. Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk Nature Genetics. 42: 464-464. DOI: 10.1038/Ng0510-464A |
0.393 |
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| 2009 |
Manning AK, Ngwa JS, Hendricks AE, Liu CT, Johnson AD, Dupuis J, Cupples LA. Incorporating biological knowledge in the search for gene x gene interaction in genome-wide association studies. Bmc Proceedings. 3: S81. PMID 20018077 DOI: 10.1186/1753-6561-3-S7-S81 |
0.421 |
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| 2009 |
An P, Mukherjee O, Chanda P, Yao L, Engelman CD, Huang CH, Zheng T, Kovac IP, Dubé MP, Liang X, Li J, de Andrade M, Culverhouse R, Malzahn D, Manning AK, et al. The challenge of detecting epistasis (G x G interactions): Genetic Analysis Workshop 16. Genetic Epidemiology. 33: S58-67. PMID 19924703 DOI: 10.1002/Gepi.20474 |
0.375 |
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| 2009 |
Edmondson AC, Brown RJ, Kathiresan S, Cupples LA, Demissie S, Manning AK, Jensen MK, Rimm EB, Wang J, Rodrigues A, Bamba V, Khetarpal SA, Wolfe ML, Derohannessian S, Li M, et al. Loss-of-function variants in endothelial lipase are a cause of elevated HDL cholesterol in humans. The Journal of Clinical Investigation. 119: 1042-50. PMID 19287092 DOI: 10.1172/Jci37176 |
0.603 |
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| 2009 |
Dupuis J, Shi J, Manning AK, Benjamin EJ, Meigs JB, Cupples LA, Siegmund D. Mapping quantitative traits in unselected families: algorithms and examples. Genetic Epidemiology. 33: 617-27. PMID 19278016 DOI: 10.1002/Gepi.20413 |
0.359 |
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| 2009 |
Stolerman ES, Manning AK, McAteer JB, Fox CS, Dupuis J, Meigs JB, Florez JC. TCF7L2 variants are associated with increased proinsulin/insulin ratios but not obesity traits in the Framingham Heart Study. Diabetologia. 52: 614-20. PMID 19183934 DOI: 10.1007/S00125-009-1266-2 |
0.434 |
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| 2009 |
Lieb W, Manning AK, Florez JC, Dupuis J, Cupples LA, McAteer JB, Vasan RS, Hoffmann U, O'Donnell CJ, Meigs JB, Fox CS. Variants in the CNR1 and the FAAH genes and adiposity traits in the community. Obesity (Silver Spring, Md.). 17: 755-60. PMID 19165169 DOI: 10.1038/Oby.2008.608 |
0.455 |
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| 2009 |
Hivert MF, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC. Association of variants in RETN with plasma resistin levels and diabetes-related traits in the Framingham Offspring Study. Diabetes. 58: 750-6. PMID 19074981 DOI: 10.2337/Db08-1339 |
0.512 |
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| 2009 |
Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJ, Manning AK, Jackson AU, Aulchenko Y, Potter SC, Erdos MR, Sanna S, Hottenga JJ, Wheeler E, et al. Variants in MTNR1B influence fasting glucose levels. Nature Genetics. 41: 77-81. PMID 19060907 DOI: 10.1038/Ng.290 |
0.483 |
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| 2008 |
Meigs JB, Shrader P, Sullivan LM, McAteer JB, Fox CS, Dupuis J, Manning AK, Florez JC, Wilson PW, D'Agostino RB, Cupples LA. Genotype score in addition to common risk factors for prediction of type 2 diabetes. The New England Journal of Medicine. 359: 2208-19. PMID 19020323 DOI: 10.1056/Nejmoa0804742 |
0.439 |
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| 2008 |
Hivert MF, Manning AK, McAteer JB, Florez JC, Dupuis J, Fox CS, O'Donnell CJ, Cupples LA, Meigs JB. Common variants in the adiponectin gene (ADIPOQ) associated with plasma adiponectin levels, type 2 diabetes, and diabetes-related quantitative traits: the Framingham Offspring Study. Diabetes. 57: 3353-9. PMID 18776141 DOI: 10.2337/Db08-0700 |
0.502 |
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| 2008 |
Meigs JB, Manning AK, Dupuis J, Liu C, Florez JC, Cupples LA. Ordered stratification to reduce heterogeneity in linkage to diabetes-related quantitative traits. Obesity (Silver Spring, Md.). 16: 2314-22. PMID 18719643 DOI: 10.1038/Oby.2008.354 |
0.423 |
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| 2008 |
Stolerman ES, Manning AK, McAteer JB, Dupuis J, Fox CS, Cupples LA, Meigs JB, Florez JC. Haplotype structure of the ENPP1 Gene and Nominal Association of the K121Q missense single nucleotide polymorphism with glycemic traits in the Framingham Heart Study. Diabetes. 57: 1971-7. PMID 18426862 DOI: 10.2337/Db08-0266 |
0.504 |
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| 2007 |
Kathiresan S, Manning AK, Demissie S, D'Agostino RB, Surti A, Guiducci C, Gianniny L, Burtt NP, Melander O, Orho-Melander M, Arnett DK, Peloso GM, Ordovas JM, Cupples LA. A genome-wide association study for blood lipid phenotypes in the Framingham Heart Study. Bmc Medical Genetics. 8: S17. PMID 17903299 DOI: 10.1186/1471-2350-8-S1-S17 |
0.66 |
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| 2007 |
Meigs JB, Manning AK, Fox CS, Florez JC, Liu C, Cupples LA, Dupuis J. Genome-wide association with diabetes-related traits in the Framingham Heart Study. Bmc Medical Genetics. 8: S16. PMID 17903298 DOI: 10.1186/1471-2350-8-S1-S16 |
0.515 |
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| 2007 |
Cupples LA, Arruda HT, Benjamin EJ, D'Agostino RB, Demissie S, DeStefano AL, Dupuis J, Falls KM, Fox CS, Gottlieb DJ, Govindaraju DR, Guo CY, Heard-Costa NL, Hwang SJ, Kathiresan S, ... ... Manning AK, et al. The Framingham Heart Study 100K SNP genome-wide association study resource: overview of 17 phenotype working group reports. Bmc Medical Genetics. 8: S1. PMID 17903291 DOI: 10.1186/1471-2350-8-S1-S1 |
0.712 |
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| 2007 |
Florez JC, Manning AK, Dupuis J, McAteer J, Irenze K, Gianniny L, Mirel DB, Fox CS, Cupples LA, Meigs JB. A 100K genome-wide association scan for diabetes and related traits in the Framingham Heart Study: replication and integration with other genome-wide datasets. Diabetes. 56: 3063-74. PMID 17848626 DOI: 10.2337/Db07-0451 |
0.487 |
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| 2007 |
Zhu H, Tucker HM, Grear KE, Simpson JF, Manning AK, Cupples LA, Estus S. A common polymorphism decreases low-density lipoprotein receptor exon 12 splicing efficiency and associates with increased cholesterol. Human Molecular Genetics. 16: 1765-72. PMID 17517690 DOI: 10.1093/Hmg/Ddm124 |
0.431 |
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| 2007 |
Maia AL, Dupuis J, Manning A, Liu C, Meigs JB, Cupples LA, Larsen PR, Fox CS. The type 2 deiodinase (DIO2) A/G polymorphism is not associated with glycemic traits: the Framingham Heart Study. Thyroid : Official Journal of the American Thyroid Association. 17: 199-202. PMID 17381351 DOI: 10.1089/Thy.2006.0298 |
0.455 |
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| 2007 |
Corella D, Lai CQ, Demissie S, Cupples LA, Manning AK, Tucker KL, Ordovas JM. APOA5 gene variation modulates the effects of dietary fat intake on body mass index and obesity risk in the Framingham Heart Study. Journal of Molecular Medicine (Berlin, Germany). 85: 119-28. PMID 17211608 DOI: 10.1007/S00109-006-0147-0 |
0.593 |
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| 2006 |
Herbert A, Liu C, Karamohamed S, Liu J, Manning A, Fox CS, Meigs JB, Cupples LA. BMI modifies associations of IL-6 genotypes with insulin resistance: the Framingham Study. Obesity (Silver Spring, Md.). 14: 1454-61. PMID 16988089 DOI: 10.1038/Oby.2006.165 |
0.393 |
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