| Year |
Citation |
Score |
| 2020 |
Olson KC, Moosic KB, Jones MK, Larkin PMK, Olson TL, Toro MF, Fox TE, Feith DJ, Loughran TP. Large granular lymphocyte leukemia serum and corresponding hematological parameters reveal unique cytokine and sphingolipid biomarkers and associations with STAT3 mutations. Cancer Medicine. PMID 32710512 DOI: 10.1002/Cam4.3246 |
0.329 |
|
| 2020 |
Annageldiyev C, Tan SF, Thakur S, Dhanyamraju PK, Ramisetti SR, Bhadauria P, Schick J, Zeng Z, Sharma V, Dunton W, Dovat S, Desai D, Zheng H, Feith DJ, Loughran TP, et al. The PI3K/AKT Pathway Inhibitor ISC-4 Induces Apoptosis and Inhibits Growth of Leukemia in Preclinical Models of Acute Myeloid Leukemia. Frontiers in Oncology. 10: 393. PMID 32296637 DOI: 10.3389/Fonc.2020.00393 |
0.42 |
|
| 2020 |
LeBlanc FR, Pearson JM, Tan SF, Cheon H, Xing JC, Dunton W, Feith DJ, Loughran TP. Sphingosine kinase-2 is overexpressed in large granular lymphocyte leukaemia and promotes survival through Mcl-1. British Journal of Haematology. PMID 32124438 DOI: 10.1111/Bjh.16530 |
0.429 |
|
| 2020 |
Wang TT, Yang J, Dighe S, Schmachtenberg MW, Leigh NT, Farber E, Onengut-Gumuscu S, Feith DJ, Ratan A, Loughran TP, Olson TL. Whole Genome Sequencing of Spontaneously Occurring Rat Natural Killer Large Granular Lymphocyte Leukemia Identifies JAK1 Somatic Activating Mutation. Cancers. 12. PMID 31947841 DOI: 10.3390/Cancers12010126 |
0.312 |
|
| 2019 |
Pearson JM, Tan SF, Sharma A, Annageldiyev C, Fox TE, Abad JL, Fabrias G, Desai D, Amin S, Wang HG, Cabot MC, Claxton DF, Kester M, Feith DJ, Loughran TP. Ceramide analog SACLAC modulates sphingolipid levels and Mcl-1 splicing to induce apoptosis in acute myeloid leukemia. Molecular Cancer Research : McR. PMID 31744877 DOI: 10.1158/1541-7786.Mcr-19-0619 |
0.428 |
|
| 2019 |
Moosic KB, Paila U, Olson KC, Dziewulska K, Wang TT, Xing JC, Ratan A, Feith DJ, Loughran TP, Olson TL. Genomics of LGL leukemia and select other rare leukemia/lymphomas. Best Practice & Research. Clinical Haematology. 32: 196-206. PMID 31585620 DOI: 10.1016/J.Beha.2019.06.003 |
0.319 |
|
| 2019 |
Kao LP, Morad SAF, Davis TS, MacDougall MR, Kassai M, Abdelmageed N, Fox TE, Kester M, Loughran TP, Abad JL, Fabrias G, Tan SF, Feith DJ, Claxton DF, Spiegel S, et al. Chemotherapy selection pressure alters sphingolipid composition and mitochondrial bioenergetics in resistant HL-60 cells. Journal of Lipid Research. PMID 31363040 DOI: 10.1194/Jlr.Ra119000251 |
0.369 |
|
| 2019 |
Annageldiyev C, Gowda K, Patel T, Bhattacharya P, Tan SF, Iyer S, Desai D, Dovat S, Feith DJ, Loughran TP, Amin S, Claxton D, Sharma A. The novel Isatin analog KS99 targets stemness markers in acute myeloid leukemia. Haematologica. PMID 31123028 DOI: 10.3324/Haematol.2018.212886 |
0.368 |
|
| 2019 |
Morad SAF, MacDougall MR, Abdelmageed N, Kao LP, Feith DJ, Tan SF, Kester M, Loughran TP, Wang HG, Cabot MC. Pivotal role of mitophagy in response of acute myelogenous leukemia to a ceramide-tamoxifen-containing drug regimen. Experimental Cell Research. PMID 31112736 DOI: 10.1016/J.Yexcr.2019.05.021 |
0.405 |
|
| 2019 |
Tan SF, Dunton W, Liu X, Fox TE, Morad SAF, Desai D, Doi K, Conaway MR, Amin S, Claxton DF, Wang HG, Kester M, Cabot MC, Feith DJ, Loughran TP. Acid ceramidase promotes drug resistance in acute myeloid leukemia through NF-kB-dependent P-glycoprotein upregulation. Journal of Lipid Research. PMID 30962310 DOI: 10.1194/Jlr.M091876 |
0.319 |
|
| 2018 |
Olson KC, Kulling Larkin PM, Signorelli R, Hamele CE, Olson TL, Conaway MR, Feith DJ, Loughran TP. Vitamin D pathway activation selectively deactivates signal transducer and activator of transcription (STAT) proteins and inflammatory cytokine production in natural killer leukemic large granular lymphocytes. Cytokine. 111: 551-562. PMID 30455079 DOI: 10.1016/J.Cyto.2018.09.016 |
0.361 |
|
| 2018 |
Yang J, LeBlanc FR, Dighe SA, Hamele CE, Olson TL, Feith DJ, Loughran TP. TRAIL mediates and sustains constitutive NF-κB activation in LGL leukemia. Blood. PMID 29699990 DOI: 10.1182/Blood-2017-09-808816 |
0.385 |
|
| 2018 |
Kulling PM, Olson KC, Hamele CE, Toro MF, Tan SF, Feith DJ, Loughran TP. Dysregulation of the IFN-γ-STAT1 signaling pathway in a cell line model of large granular lymphocyte leukemia. Plos One. 13: e0193429. PMID 29474442 DOI: 10.1371/Journal.Pone.0193429 |
0.349 |
|
| 2017 |
Tan SF, Pearson JM, Feith DJ, Loughran TP. The emergence of acid ceramidase as a therapeutic target for acute myeloid leukemia. Expert Opinion On Therapeutic Targets. PMID 28434262 DOI: 10.1080/14728222.2017.1322065 |
0.344 |
|
| 2017 |
Morad SA, Davis TS, MacDougall MR, Tan SF, Feith DJ, Desai DH, Amin SG, Kester M, Loughran TP, Cabot MC. Role of P-glycoprotein inhibitors in ceramide-based therapeutics for treatment of cancer. Biochemical Pharmacology. PMID 28189725 DOI: 10.1016/J.Bcp.2017.02.002 |
0.379 |
|
| 2017 |
LeBlanc FR, Yang J, Heller JH, Dighe S, Gru AA, Dunlap-Brown M, Wang H, Feith DJ, Loughran TP. Therapeutic Efficacy of Mcl-1 Antagonism in Large Granular Lymphocyte Leukemia Blood. 130: 1217-1217. DOI: 10.1182/Blood.V130.Suppl_1.1217.1217 |
0.425 |
|
| 2017 |
Pearson JM, Tan S, Sharma A, Fox TE, Abad JL, Fabrias G, Claxton DF, Feith DJ, Kester M, Loughran TP. Abstract 48: Acid ceramidase inhibition: A targeted therapy for acute myeloid leukemia Clinical Cancer Research. 23: 48-48. DOI: 10.1158/1557-3265.Hemmal17-48 |
0.397 |
|
| 2016 |
Tan SF, Liu X, Fox TE, Barth BM, Sharma A, Turner SD, Awwad A, Dewey A, Doi K, Spitzer B, Shah MV, Morad SA, Desai D, Amin S, Zhu J, ... ... Feith DJ, et al. Acid ceramidase is upregulated in AML and represents a novel therapeutic target. Oncotarget. PMID 27825124 DOI: 10.18632/Oncotarget.13079 |
0.464 |
|
| 2016 |
Olson KC, Kulling PM, Olson TL, Tan SF, Rainbow RJ, Feith DJ, Loughran TP. Vitamin D decreases STAT phosphorylation and inflammatory cytokine output in T-LGL Leukemia. Cancer Biology & Therapy. 0. PMID 27715403 DOI: 10.1080/15384047.2016.1235669 |
0.369 |
|
| 2016 |
Keller RR, Gestl SA, Lu AQ, Hoke A, Feith DJ, Gunther EJ. Carcinogen-specific mutations in preferred Ras-Raf pathway oncogenes directed by strand bias. Carcinogenesis. PMID 27207659 DOI: 10.1093/Carcin/Bgw061 |
0.315 |
|
| 2016 |
Morad SA, Ryan TE, Neufer PD, Zeczycki TN, Davis TS, MacDougall MR, Fox TE, Tan SF, Feith DJ, Loughran TP, Kester M, Claxton DF, Barth BM, Deering TG, Cabot MC. Ceramide-tamoxifen regimen targets bioenergetic elements in acute myelogenous leukemia. Journal of Lipid Research. PMID 27140664 DOI: 10.1194/Jlr.M067389 |
0.359 |
|
| 2016 |
Yang J, Leblanc FR, Dighe S, Nyland SB, Feith DJ, Loughran TP. Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand (TRAIL) Mediates and Sustains NF-κb Constitutive Activation in LGL Leukemia Cells Blood. 128: 2762-2762. DOI: 10.1182/Blood.V128.22.2762.2762 |
0.406 |
|
| 2015 |
LeBlanc FR, Liu X, Hengst J, Fox T, Calvert V, Petricoin EF, Yun J, Feith DJ, Loughran TP. Sphingosine kinase inhibitors decrease viability and induce cell death in natural killer-large granular lymphocyte leukemia. Cancer Biology & Therapy. 0. PMID 26252351 DOI: 10.1080/15384047.2015.1078949 |
0.398 |
|
| 2015 |
Morad SA, Tan SF, Feith DJ, Kester M, Claxton DF, Loughran TP, Barth BM, Fox TE, Cabot MC. Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia-Impact on enzyme activity and response to cytotoxics. Biochimica Et Biophysica Acta. 1851: 919-28. PMID 25769964 DOI: 10.1016/J.Bbalip.2015.03.001 |
0.441 |
|
| 2015 |
Sun X, Hasanali ZS, Chen A, Zhang D, Liu X, Wang HG, Feith DJ, Loughran TP, Xu K. Suberoylanilide hydroxamic acid (SAHA) and cladribine synergistically induce apoptosis in NK-LGL leukaemia. British Journal of Haematology. 168: 371-83. PMID 25284154 DOI: 10.1111/Bjh.13143 |
0.358 |
|
| 2015 |
LeBlanc FR, Wang H, Feith DJ, Loughran TP. FTY720 (Fingolimod) Targets the Sphingolipid Pathway and Induces Autophagy-Related Apoptosis in Human Natural Killer Large Granular Lymphocyte Leukemia Blood. 126: 1288-1288. DOI: 10.1182/Blood.V126.23.1288.1288 |
0.42 |
|
| 2015 |
Tan S, Liu X, Broeg K, Fox TE, Feith DJ, Loughran TP. Acid Ceramidase Inhibition Impairs Tumor Progression in a Rat Model of LGL Leukemia Blood. 126: 1246-1246. DOI: 10.1182/Blood.V126.23.1246.1246 |
0.42 |
|
| 2014 |
Lange I, Geerts D, Feith DJ, Mocz G, Koster J, Bachmann AS. Novel interaction of ornithine decarboxylase with sepiapterin reductase regulates neuroblastoma cell proliferation. Journal of Molecular Biology. 426: 332-46. PMID 24096079 DOI: 10.1016/J.Jmb.2013.09.037 |
0.389 |
|
| 2014 |
Tan S, Liu X, Doi K, Wang H, Cabot M, Feith D, Loughran TP. Abstract 761: Acid ceramidase promotes drug resistance in acute myeloid leukemia through P-gp upregulation mediated by NF- kB activation Cancer Research. 74: 761-761. DOI: 10.1158/1538-7445.Am2014-761 |
0.359 |
|
| 2013 |
Ryland LK, Doshi UA, Shanmugavelandy SS, Fox TE, Aliaga C, Broeg K, Baab KT, Young M, Khan O, Haakenson JK, Jarbadan NR, Liao J, Wang HG, Feith DJ, Loughran TP, et al. C6-ceramide nanoliposomes target the Warburg effect in chronic lymphocytic leukemia. Plos One. 8: e84648. PMID 24367685 DOI: 10.1371/Journal.Pone.0084648 |
0.417 |
|
| 2013 |
Morad SA, Levin JC, Tan SF, Fox TE, Feith DJ, Cabot MC. Novel off-target effect of tamoxifen--inhibition of acid ceramidase activity in cancer cells. Biochimica Et Biophysica Acta. 1831: 1657-64. PMID 23939396 DOI: 10.1016/J.Bbalip.2013.07.016 |
0.382 |
|
| 2013 |
Koomoa DL, Geerts D, Lange I, Koster J, Pegg AE, Feith DJ, Bachmann AS. DFMO/eflornithine inhibits migration and invasion downstream of MYCN and involves p27Kip1 activity in neuroblastoma. International Journal of Oncology. 42: 1219-28. PMID 23440295 DOI: 10.3892/Ijo.2013.1835 |
0.549 |
|
| 2013 |
Feith DJ, Pegg AE, Fong LY. Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice. Carcinogenesis. 34: 570-6. PMID 23222816 DOI: 10.1093/Carcin/Bgs377 |
0.585 |
|
| 2013 |
Brown TJ, Garcia AM, Tan S, Kissinger LN, Feith DJ, Barth BM, Claxton DF. Abstract 3396: Improving the anti-AML efficacy of liposomal ceramide by targeting sphingolipid metabolism. Cancer Research. 73: 3396-3396. DOI: 10.1158/1538-7445.Am2013-3396 |
0.402 |
|
| 2012 |
Shi C, Cooper TK, McCloskey DE, Glick AB, Shantz LM, Feith DJ. S-adenosylmethionine decarboxylase overexpression inhibits mouse skin tumor promotion. Carcinogenesis. 33: 1310-8. PMID 22610166 DOI: 10.1093/Carcin/Bgs184 |
0.661 |
|
| 2012 |
Welsh PA, Sass-Kuhn S, Prakashagowda C, McCloskey DE, Feith DJ. Spermine synthase overexpression in vivo does not increase susceptibility to DMBA/TPA skin carcinogenesis or Min-Apc intestinal tumorigenesis Cancer Biology and Therapy. 13: 358-368. PMID 22258329 DOI: 10.4161/Cbt.19241 |
0.479 |
|
| 2012 |
Shi C, Welsh PA, Sass-Kuhn S, Wang X, McCloskey DE, Pegg AE, Feith DJ. Characterization of transgenic mice with overexpression of spermidine synthase. Amino Acids. 42: 495-505. PMID 21809077 DOI: 10.1007/S00726-011-1028-6 |
0.673 |
|
| 2012 |
Carr TD, Feith DJ, Shantz LM. Abstract 5219: The role of MEK and Antizyme in keratinocyte stem cell expansion and differentiation Cancer Research. 72: 5219-5219. DOI: 10.1158/1538-7445.Am2012-5219 |
0.474 |
|
| 2011 |
Feith DJ. Carcinogenesis studies in mice with genetically engineered alterations in polyamine metabolism. Methods in Molecular Biology (Clifton, N.J.). 720: 129-41. PMID 21318870 DOI: 10.1007/978-1-61779-034-8_7 |
0.446 |
|
| 2011 |
Feith DJ, Welsh PA, Prakashagowda C, Gunther EJ, Verderame MF. Abstract 829: Targeted antizyme expression impairs HER2/neu-induced tumorigenesis but not normal mammary gland development Cancer Research. 71: 829-829. DOI: 10.1158/1538-7445.Am2011-829 |
0.328 |
|
| 2010 |
Geerts D, Koster J, Albert D, Koomoa DL, Feith DJ, Pegg AE, Volckmann R, Caron H, Versteeg R, Bachmann AS. The polyamine metabolism genes ornithine decarboxylase and antizyme 2 predict aggressive behavior in neuroblastomas with and without MYCN amplification. International Journal of Cancer. 126: 2012-24. PMID 19960435 DOI: 10.1002/Ijc.25074 |
0.533 |
|
| 2010 |
Shi C, McCloskey DE, Pegg AE, Feith DJ. Abstract 2483: Transgenic mice to evaluate the role of S-adenosylmethionine decarboxylase in skin carcinogenesis Cancer Research. 70: 2483-2483. DOI: 10.1158/1538-7445.Am10-2483 |
0.695 |
|
| 2009 |
Koomoa DL, Borsics T, Feith DJ, Coleman CC, Wallick CJ, Gamper I, Pegg AE, Bachmann AS. Inhibition of S-adenosylmethionine decarboxylase by inhibitor SAM486A connects polyamine metabolism with p53-Mdm2-Akt/protein kinase B regulation and apoptosis in neuroblastoma. Molecular Cancer Therapeutics. 8: 2067-75. PMID 19584241 DOI: 10.1158/1535-7163.Mct-08-1217 |
0.548 |
|
| 2007 |
Wang X, Feith DJ, Welsh P, Coleman CS, Lopez C, Woster PM, O'brien TG, Pegg AE. Studies of the mechanism by which increased spermidine/spermine N1-acetyltransferase activity increases susceptibility to skin carcinogenesis Carcinogenesis. 28: 2404-2411. PMID 17675337 DOI: 10.1093/Carcin/Bgm162 |
0.586 |
|
| 2007 |
Pegg AE, Feith DJ. Polyamines and neoplastic growth. Biochemical Society Transactions. 35: 295-9. PMID 17371264 DOI: 10.1042/Bst0350295 |
0.516 |
|
| 2007 |
Feith DJ, Shantz LM, Shoop PL, Keefer KA, Prakashagowda C, Pegg AE. Mouse skin chemical carcinogenesis is inhibited by antizyme in promotion-sensitive and promotion-resistant genetic backgrounds. Molecular Carcinogenesis. 46: 453-65. PMID 17219416 DOI: 10.1002/Mc.20294 |
0.589 |
|
| 2006 |
Feith DJ, Origanti S, Shoop PL, Sass-Kuhn S, Shantz LM. Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis. Carcinogenesis. 27: 1090-8. PMID 16400186 DOI: 10.1093/Carcin/Bgi343 |
0.478 |
|
| 2005 |
Wallick CJ, Gamper I, Thorne M, Feith DJ, Takasaki KY, Wilson SM, Seki JA, Pegg AE, Byus CV, Bachmann AS. Key role for p27Kip1, retinoblastoma protein Rb, and MYCN in polyamine inhibitor-induced G1 cell cycle arrest in MYCN-amplified human neuroblastoma cells. Oncogene. 24: 5606-18. PMID 16007177 DOI: 10.1038/Sj.Onc.1208808 |
0.528 |
|
| 2005 |
Feith DJ, Bol DK, Carboni JM, Lynch MJ, Sass-Kuhn S, Shoop PL, Shantz LM. Induction of ornithine decarboxylase activity is a necessary step for mitogen-activated protein kinase kinase-induced skin tumorigenesis. Cancer Research. 65: 572-8. PMID 15695401 |
0.336 |
|
| 2004 |
Tang X, Kim AL, Feith DJ, Pegg AE, Russo J, Zhang H, Aszterbaum M, Kopelovich L, Epstein EH, Bickers DR, Athar M. Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/- mice. The Journal of Clinical Investigation. 113: 867-75. PMID 15067319 DOI: 10.1172/Jci20732 |
0.612 |
|
| 2003 |
Fong LY, Feith DJ, Pegg AE. Antizyme overexpression in transgenic mice reduces cell proliferation, increases apoptosis, and reduces N-nitrosomethylbenzylamine-induced forestomach carcinogenesis. Cancer Research. 63: 3945-54. PMID 12873989 |
0.586 |
|
| 2003 |
Pegg AE, Feith DJ, Fong LY, Coleman CS, O'Brien TG, Shantz LM. Transgenic mouse models for studies of the role of polyamines in normal, hypertrophic and neoplastic growth. Biochemical Society Transactions. 31: 356-60. PMID 12653638 DOI: 10.1042/Bst0310356 |
0.584 |
|
| 2001 |
Feith DJ, Shantz LM, Pegg AE. Targeted antizyme expression in the skin of transgenic mice reduces tumor promoter induction of ornithine decarboxylase and decreases sensitivity to chemical carcinogenesis. Cancer Research. 61: 6073-81. PMID 11507056 |
0.52 |
|
| 2001 |
Shantz LM, Feith DJ, Pegg AE. Targeted overexpression of ornithine decarboxylase enhances beta-adrenergic agonist-induced cardiac hypertrophy. The Biochemical Journal. 358: 25-32. PMID 11485548 DOI: 10.1042/0264-6021:3580025 |
0.515 |
|
| 2000 |
Mackintosh CA, Feith DJ, Shantz LM, Pegg AE. Overexpression of antizyme in the hearts of transgenic mice prevents the isoprenaline-induced increase in cardiac ornithine decarboxylase activity and polyamines, but does not prevent cardiac hypertrophy. The Biochemical Journal. 350: 645-53. PMID 10970775 DOI: 10.1042/Bj3500645 |
0.558 |
|
| 1998 |
Pegg AE, Xiong H, Feith DJ, Shantz LM. S-adenosylmethionine decarboxylase: structure, function and regulation by polyamines. Biochemical Society Transactions. 26: 580-6. PMID 10047786 DOI: 10.1042/Bst0260580 |
0.425 |
|
| 1998 |
Matés JM, del Valle AE, Urdiales JL, Coleman CS, Feith D, Olmo MT, Pegg AE, Sánchez-Jiménez F. Structure/function relationship studies on the T/S residues 173-177 of rat ODC. Biochimica Et Biophysica Acta. 1386: 113-20. PMID 9675257 DOI: 10.1016/S0167-4838(98)00090-9 |
0.448 |
|
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