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Stuart Shuman - Publications

Affiliations: 
Weill Cornell Medical College, New York, NY, United States 
Area:
Molecular Biology
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Year Citation  Score
2020 Ghosh S, Goldgur Y, Shuman S. Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme. Nucleic Acids Research. PMID 32034423 DOI: 10.1093/Nar/Gkaa075  0.588
2019 Jia N, Unciuleac MC, Xue C, Greene EC, Patel DJ, Shuman S. Structures and single-molecule analysis of bacterial motor nuclease AdnAB illuminate the mechanism of DNA double-strand break resection. Proceedings of the National Academy of Sciences of the United States of America. PMID 31740608 DOI: 10.1073/pnas.1913546116  0.582
2019 Munir A, Shuman S. Structure-function analysis of the phosphoesterase component of the nucleic acid end-healing enzyme HD-Pnk. Journal of Bacteriology. PMID 31160396 DOI: 10.1128/Jb.00292-19  0.388
2019 Garg A, Goldgur Y, Sanchez AM, Schwer B, Shuman S. Structure of fission yeast transcription factor Pho7 bound to promoter DNA and effect of Pho7 mutations on DNA binding and phosphate homeostasis. Molecular and Cellular Biology. PMID 31010807 DOI: 10.1128/Mcb.00132-19  0.522
2019 Ejaz A, Goldgur Y, Shuman S. Activity and structure of MPE, a manganese-dependent single-strand DNA endonuclease encoded in a nucleic acid repair gene cluster. The Journal of Biological Chemistry. PMID 30894417 DOI: 10.1074/Jbc.Ra119.008049  0.636
2019 Unciuleac MC, Goldgur Y, Shuman S. Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates. The Journal of Biological Chemistry. PMID 30718283 DOI: 10.1074/Jbc.Ra119.007445  0.561
2018 Ejaz A, Shuman S. Characterization of Lhr-Core DNA helicase and Mn-dependent DNA nuclease components of a bacterial gene cluster encoding nucleic acid repair enzymes. The Journal of Biological Chemistry. PMID 30224353 DOI: 10.1074/Jbc.Ra118.005296  0.613
2018 Garg A, Goldgur Y, Schwer B, Shuman S. Distinctive structural basis for DNA recognition by the fission yeast Zn2Cys6 transcription factor Pho7 and its role in phosphate homeostasis. Nucleic Acids Research. PMID 30212894 DOI: 10.1093/nar/gky827  0.394
2018 Munir A, Banerjee A, Shuman S. NAD+-dependent synthesis of a 5'-phospho-ADP-ribosylated RNA/DNA cap by RNA 2'-phosphotransferase Tpt1. Nucleic Acids Research. PMID 30202863 DOI: 10.1093/Nar/Gky792  0.316
2018 Schmier BJ, Shuman S. HD-Pnk, a nucleic acid end-healing enzyme, abets resistance to killing by ionizing radiation and mitomycin C. Journal of Bacteriology. PMID 29891641 DOI: 10.1128/Jb.00151-18  0.4
2017 Ejaz A, Ordonez H, Jacewicz A, Ferrao R, Shuman S. Structure of mycobacterial 3'-to-5' RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases. Nucleic Acids Research. PMID 29165676 DOI: 10.1093/Nar/Gkx1163  0.514
2017 Schwer B, Sanchez AM, Garg A, Chatterjee D, Shuman S. Defining the DNA Binding Site Recognized by the Fission Yeast Zn2Cys6 Transcription Factor Pho7 and Its Role in Phosphate Homeostasis. Mbio. 8. PMID 28811350 DOI: 10.1128/Mbio.01218-17  0.392
2017 Uson ML, Ghosh S, Shuman S. The DNA repair repertoire of Mycobacterium smegmatis FenA includes the incision of DNA 5' flaps and the removal of 5' adenylylated products of aborted nick ligation. Journal of Bacteriology. PMID 28630124 DOI: 10.1128/Jb.00304-17  0.616
2017 Reed BR, Yakovleva L, Shuman S, Ghose R. Characterization of DNA binding by the isolated N-terminal domain of vaccinia virus DNA topoisomerase IB. Biochemistry. PMID 28570045 DOI: 10.1021/Acs.Biochem.7B00042  0.609
2017 Unciuleac MC, Goldgur Y, Shuman S. Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD(+)-dependent polynucleotide ligases. Proceedings of the National Academy of Sciences of the United States of America. PMID 28223499 DOI: 10.1073/Pnas.1619220114  0.306
2016 Gupta R, Unciuleac MC, Shuman S, Glickman MS. Homologous recombination mediated by the mycobacterial AdnAB helicase without end resection by the AdnAB nucleases. Nucleic Acids Research. PMID 27899634 DOI: 10.1093/Nar/Gkw1130  0.55
2016 Gupta R, Chatterjee D, Glickman MS, Shuman S. Division of labor among Mycobacterium smegmatis RNase H enzymes: RNase H1 activity of RnhA or RnhC is essential for growth whereas RnhB and RnhA guard against killing by hydrogen peroxide in stationary phase. Nucleic Acids Research. PMID 27899559 DOI: 10.1093/Nar/Gkw1046  0.353
2016 Munir A, Shuman S. Characterization of Runella slithyformis HD-Pnk, a bifunctional DNA/RNA end-healing enzyme composed of an N-terminal 2',3' -phosphoesterase HD domain and a C-terminal 5' -OH polynucleotide kinase domain. Journal of Bacteriology. PMID 27895092 DOI: 10.1128/Jb.00739-16  0.401
2016 Remus BS, Schwer B, Shuman S. Characterization of the tRNA ligases of pathogenic fungi Aspergillus fumigatus and Coccidioides immitis. Rna (New York, N.Y.). PMID 27492257 DOI: 10.1261/Rna.057455.116  0.309
2016 Cho JE, Huang SN, Burgers PM, Shuman S, Pommier Y, Jinks-Robertson S. Parallel analysis of ribonucleotide-dependent deletions produced by yeast Top1 in vitro and in vivo. Nucleic Acids Research. PMID 27257064 DOI: 10.1093/Nar/Gkw495  0.423
2016 Chauleau M, Shuman S. Kinetic mechanism and fidelity of nick sealing by Escherichia coli NAD+-dependent DNA ligase (LigA). Nucleic Acids Research. PMID 26857547 DOI: 10.1093/Nar/Gkw049  0.512
2016 Dai P, Wang W, Li T, Serna-Tamayo C, Shuman S, Chen Z, Deng L. 455 Inhibition of the cytosolic DNA sensor cyclic GMP-AMP synthase by poxviral virulence factor E3 Journal of Investigative Dermatology. 136: S81. DOI: 10.1016/j.jid.2016.02.491  0.327
2015 Maughan WP, Shuman S. Characterization of 3'-Phosphate RNA Ligase Paralogs RtcB1, RtcB2, and RtcB3 from Myxococcus xanthus Highlights DNA and RNA 5'-Phosphate Capping Activity of RtcB3. Journal of Bacteriology. 197: 3616-24. PMID 26350128 DOI: 10.1128/Jb.00631-15  0.492
2015 Gupta R, Shuman S, Glickman MS. RecF and RecR Play Critical Roles in the Homologous Recombination and Single-Strand Annealing Pathways of Mycobacteria. Journal of Bacteriology. 197: 3121-32. PMID 26195593 DOI: 10.1128/Jb.00290-15  0.496
2015 Uson ML, Ordonez H, Shuman S. Mycobacterium smegmatis HelY Is an RNA-Activated ATPase/dATPase and 3'-to-5' Helicase That Unwinds 3'-Tailed RNA Duplexes and RNA:DNA Hybrids. Journal of Bacteriology. 197: 3057-65. PMID 26170411 DOI: 10.1128/Jb.00418-15  0.385
2015 Chauleau M, Jacewicz A, Shuman S. DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition. Nucleic Acids Research. PMID 26007660 DOI: 10.1093/Nar/Gkv501  0.574
2015 Jacewicz A, Shuman S. Biochemical characterization of Mycobacterium smegmatis RnhC (MSMEG_4305), a bifunctional enzyme composed of autonomous N-terminal type I ribonuclease H and C-terminal acid phosphatase domains. Journal of Bacteriology. PMID 25986906 DOI: 10.1128/Jb.00268-15  0.554
2015 Chauleau M, Das U, Shuman S. Effects of DNA3'pp5'G capping on 3' end repair reactions and of an embedded pyrophosphate-linked guanylate on ribonucleotide surveillance. Nucleic Acids Research. 43: 3197-207. PMID 25753667 DOI: 10.1093/Nar/Gkv179  0.607
2014 Ordonez H, Shuman S. Mycobacterium smegmatis DinB2 misincorporates deoxyribonucleotides and ribonucleotides during templated synthesis and lesion bypass. Nucleic Acids Research. 42: 12722-34. PMID 25352547 DOI: 10.1093/Nar/Gku1027  0.48
2014 Das U, Wang LK, Smith P, Munir A, Shuman S. Structures of bacterial polynucleotide kinase in a michaelis complex with nucleoside triphosphate (NTP)-Mg2+ and 5'-OH RNA and a mixed substrate-product complex with NTP-Mg2+ and a 5'-phosphorylated oligonucleotide. Journal of Bacteriology. 196: 4285-92. PMID 25266383 DOI: 10.1128/Jb.02197-14  0.367
2014 Remus BS, Jacewicz A, Shuman S. Structure and mechanism of E. coli RNA 2',3'-cyclic phosphodiesterase. Rna (New York, N.Y.). 20: 1697-705. PMID 25239919 DOI: 10.1261/Rna.046797.114  0.302
2014 Ordonez H, Uson ML, Shuman S. Characterization of three mycobacterial DinB (DNA polymerase IV) paralogs highlights DinB2 as naturally adept at ribonucleotide incorporation. Nucleic Acids Research. 42: 11056-70. PMID 25200080 DOI: 10.1093/Nar/Gku752  0.588
2014 Das U, Chauleau M, Ordonez H, Shuman S. Impact of DNA3'pp5'G capping on repair reactions at DNA 3' ends. Proceedings of the National Academy of Sciences of the United States of America. 111: 11317-22. PMID 25049385 DOI: 10.1073/Pnas.1409203111  0.63
2014 Doamekpor SK, Sanchez AM, Schwer B, Shuman S, Lima CD. How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes. Genes & Development. 28: 1323-36. PMID 24939935 DOI: 10.1101/Gad.242768.114  0.308
2014 Kyrieleis OJ, Chang J, de la Peña M, Shuman S, Cusack S. Crystal structure of vaccinia virus mRNA capping enzyme provides insights into the mechanism and evolution of the capping apparatus. Structure (London, England : 1993). 22: 452-65. PMID 24607143 DOI: 10.1016/J.Str.2013.12.014  0.332
2014 Remus BS, Shuman S. Distinctive kinetics and substrate specificities of plant and fungal tRNA ligases. Rna (New York, N.Y.). 20: 462-73. PMID 24554441 DOI: 10.1261/Rna.043752.113  0.351
2014 Schmier BJ, Shuman S. Effects of 3'-OH and 5'-PO4 base mispairs and damaged base lesions on the fidelity of nick sealing by Deinococcus radiodurans RNA ligase. Journal of Bacteriology. 196: 1704-12. PMID 24532777 DOI: 10.1128/Jb.00020-14  0.311
2013 Das U, Chakravarty AK, Remus BS, Shuman S. Rewriting the rules for end joining via enzymatic splicing of DNA 3'-PO4 and 5'-OH ends. Proceedings of the National Academy of Sciences of the United States of America. 110: 20437-42. PMID 24218597 DOI: 10.1073/Pnas.1314289110  0.618
2013 Chauleau M, Shuman S. Kinetic mechanism of nick sealing by T4 RNA ligase 2 and effects of 3'-OH base mispairs and damaged base lesions. Rna (New York, N.Y.). 19: 1840-7. PMID 24158792 DOI: 10.1261/Rna.041731.113  0.374
2013 Unciuleac MC, Shuman S. Discrimination of RNA from DNA by polynucleotide phosphorylase. Biochemistry. 52: 6702-11. PMID 23980617 DOI: 10.1021/Bi401041V  0.527
2013 Das U, Wang LK, Smith P, Shuman S. Structural and biochemical analysis of the phosphate donor specificity of the polynucleotide kinase component of the bacterial pnkp•hen1 RNA repair system. Biochemistry. 52: 4734-43. PMID 23721485 DOI: 10.1021/Bi400412X  0.321
2013 Wang LK, Smith P, Shuman S. Structure and mechanism of the 2',3' phosphatase component of the bacterial Pnkp-Hen1 RNA repair system. Nucleic Acids Research. 41: 5864-73. PMID 23595150 DOI: 10.1093/Nar/Gkt221  0.305
2013 Unciuleac MC, Shuman S. Distinctive effects of domain deletions on the manganese-dependent DNA polymerase and DNA phosphorylase activities of Mycobacterium smegmatis polynucleotide phosphorylase. Biochemistry. 52: 2967-81. PMID 23560592 DOI: 10.1021/Bi400281W  0.516
2013 Ordonez H, Shuman S. Mycobacterium smegmatis Lhr Is a DNA-dependent ATPase and a 3'-to-5' DNA translocase and helicase that prefers to unwind 3'-tailed RNA:DNA hybrids. The Journal of Biological Chemistry. 288: 14125-34. PMID 23549043 DOI: 10.1074/Jbc.M113.466854  0.608
2013 Yakovleva L, Shuman S. Chemical mutagenesis of vaccinia DNA topoisomerase lysine 167 provides insights to the catalysis of DNA transesterification. Biochemistry. 52: 984-91. PMID 23317114 DOI: 10.1021/Bi301643H  0.457
2013 Gupta R, Ryzhikov M, Koroleva O, Unciuleac M, Shuman S, Korolev S, Glickman MS. A dual role for mycobacterial RecO in RecA-dependent homologous recombination and RecA-independent single-strand annealing. Nucleic Acids Research. 41: 2284-95. PMID 23295671 DOI: 10.1093/Nar/Gks1298  0.585
2012 Zhu H, Bhattarai H, Yan HG, Shuman S, Glickman MS. Characterization of Mycobacterium smegmatis PolD2 and PolD1 as RNA/DNA polymerases homologous to the POL domain of bacterial DNA ligase D. Biochemistry. 51: 10147-58. PMID 23198659 DOI: 10.1021/Bi301202E  0.598
2012 Meineke B, Kast A, Schwer B, Meinhardt F, Shuman S, Klassen R. A fungal anticodon nuclease ribotoxin exploits a secondary cleavage site to evade tRNA repair. Rna (New York, N.Y.). 18: 1716-24. PMID 22836353 DOI: 10.1261/Rna.034132.112  0.318
2012 Samai P, Shuman S. Kinetic analysis of DNA strand joining by Chlorella virus DNA ligase and the role of nucleotidyltransferase motif VI in ligase adenylylation. The Journal of Biological Chemistry. 287: 28609-18. PMID 22745124 DOI: 10.1074/Jbc.M112.380428  0.569
2012 Yakovleva L, Shuman S. Mycobacterium smegmatis SftH exemplifies a distinctive clade of superfamily II DNA-dependent ATPases with 3' to 5' translocase and helicase activities. Nucleic Acids Research. 40: 7465-75. PMID 22641846 DOI: 10.1093/Nar/Gks417  0.561
2012 Chakravarty AK, Subbotin R, Chait BT, Shuman S. RNA ligase RtcB splices 3'-phosphate and 5'-OH ends via covalent RtcB-(histidinyl)-GMP and polynucleotide-(3')pp(5')G intermediates. Proceedings of the National Academy of Sciences of the United States of America. 109: 6072-7. PMID 22474365 DOI: 10.1073/Pnas.1201207109  0.35
2012 Ordonez H, Unciuleac M, Shuman S. Mycobacterium smegmatis RqlH defines a novel clade of bacterial RecQ-like DNA helicases with ATP-dependent 3'-5' translocase and duplex unwinding activities. Nucleic Acids Research. 40: 4604-14. PMID 22287622 DOI: 10.1093/Nar/Gks046  0.474
2012 Natarajan A, Dutta K, Temel DB, Nair PA, Shuman S, Ghose R. Solution structure and DNA-binding properties of the phosphoesterase domain of DNA ligase D. Nucleic Acids Research. 40: 2076-88. PMID 22084199 DOI: 10.1093/Nar/Gkr950  0.545
2012 Das U, Smith P, Shuman S. Structural insights to the metal specificity of an archaeal member of the LigD 3'-phosphoesterase DNA repair enzyme family. Nucleic Acids Research. 40: 828-36. PMID 21965539 DOI: 10.1093/Nar/Gkr767  0.33
2011 Tanaka N, Chakravarty AK, Maughan B, Shuman S. Novel mechanism of RNA repair by RtcB via sequential 2',3'-cyclic phosphodiesterase and 3'-Phosphate/5'-hydroxyl ligation reactions. The Journal of Biological Chemistry. 286: 43134-43. PMID 22045815 DOI: 10.1074/Jbc.M111.302133  0.322
2011 Jain R, Poulos MG, Gros J, Chakravarty AK, Shuman S. Substrate specificity and mutational analysis of Kluyveromyces lactis gamma-toxin, a eukaryal tRNA anticodon nuclease. Rna (New York, N.Y.). 17: 1336-43. PMID 21610213 DOI: 10.1261/Rna.2722711  0.433
2011 Samai P, Shuman S. Structure-function analysis of the OB and latch domains of chlorella virus DNA ligase. The Journal of Biological Chemistry. 286: 22642-52. PMID 21527793 DOI: 10.1074/Jbc.M111.245399  0.578
2011 Simsek D, Furda A, Gao Y, Artus J, Brunet E, Hadjantonakis AK, Van Houten B, Shuman S, McKinnon PJ, Jasin M. Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature. 471: 245-8. PMID 21390132 DOI: 10.1038/Nature09794  0.539
2011 Samai P, Shuman S. Functional dissection of the DNA interface of the nucleotidyltransferase domain of chlorella virus DNA ligase. The Journal of Biological Chemistry. 286: 13314-26. PMID 21335605 DOI: 10.1074/Jbc.M111.226191  0.631
2011 Gupta R, Barkan D, Redelman-Sidi G, Shuman S, Glickman MS. Mycobacteria exploit three genetically distinct DNA double-strand break repair pathways. Molecular Microbiology. 79: 316-30. PMID 21219454 DOI: 10.1111/J.1365-2958.2010.07463.X  0.456
2011 Dutta K, Natarajan A, Nair PA, Shuman S, Ghose R. Sequence-specific 1H, 13C and 15N assignments of the phosphoesterase (PE) domain of Pseudomonas aeruginosa DNA ligase D (LigD). Biomolecular Nmr Assignments. 5: 151-5. PMID 21213076 DOI: 10.1007/S12104-010-9289-7  0.551
2011 Smith P, Nair PA, Das U, Zhu H, Shuman S. Structures and activities of archaeal members of the LigD 3'-phosphoesterase DNA repair enzyme superfamily. Nucleic Acids Research. 39: 3310-20. PMID 21208981 DOI: 10.1093/Nar/Gkq1163  0.504
2011 Chakravarty AK, Shuman S. RNA 3'-phosphate cyclase (RtcA) catalyzes ligase-like adenylylation of DNA and RNA 5'-monophosphate ends. The Journal of Biological Chemistry. 286: 4117-22. PMID 21098490 DOI: 10.1074/Jbc.M110.196766  0.422
2010 Unciuleac MC, Shuman S. Double strand break unwinding and resection by the mycobacterial helicase-nuclease AdnAB in the presence of single strand DNA-binding protein (SSB). The Journal of Biological Chemistry. 285: 34319-29. PMID 20736178 DOI: 10.1074/Jbc.M110.162925  0.569
2010 Nair PA, Smith P, Shuman S. Structure of bacterial LigD 3'-phosphoesterase unveils a DNA repair superfamily. Proceedings of the National Academy of Sciences of the United States of America. 107: 12822-7. PMID 20616014 DOI: 10.1073/Pnas.1005830107  0.614
2010 Patel A, Yakovleva L, Shuman S, Mondragón A. Crystal structure of a bacterial topoisomerase IB in complex with DNA reveals a secondary DNA binding site. Structure (London, England : 1993). 18: 725-33. PMID 20541510 DOI: 10.1016/J.Str.2010.03.007  0.655
2010 Zhu H, Shuman S. Gap filling activities of Pseudomonas DNA ligase D (LigD) polymerase and functional interactions of LigD with the DNA end-binding Ku protein. The Journal of Biological Chemistry. 285: 4815-25. PMID 20018881 DOI: 10.1074/Jbc.M109.073874  0.636
2010 Jain R, Shuman S. Bacterial Hen1 is a 3' terminal RNA ribose 2'-O-methyltransferase component of a bacterial RNA repair cassette. Rna (New York, N.Y.). 16: 316-23. PMID 20007328 DOI: 10.1261/Rna.1926510  0.323
2010 Wang LK, Shuman S. Mutational analysis of the 5'-OH oligonucleotide phosphate acceptor site of T4 polynucleotide kinase. Nucleic Acids Research. 38: 1304-11. PMID 19966275 DOI: 10.1093/Nar/Gkp1096  0.317
2010 Unciuleac MC, Shuman S. Characterization of the mycobacterial AdnAB DNA motor provides insights into the evolution of bacterial motor-nuclease machines Journal of Biological Chemistry. 285: 2632-2641. PMID 19920138 DOI: 10.1074/Jbc.M109.076133  0.468
2010 Piserchio A, Nair PA, Shuman S, Ghose R. Solution NMR studies of Chlorella virus DNA ligase-adenylate. Journal of Molecular Biology. 395: 291-308. PMID 19913033 DOI: 10.1016/J.Jmb.2009.11.007  0.468
2009 Piserchio A, Nair PA, Shuman S, Ghose R. Sequence-specific 1H N, 13C, and 15N backbone resonance assignments of the 34 kDa Paramecium bursaria Chlorella virus 1 (PBCV1) DNA ligase. Biomolecular Nmr Assignments. 3: 77-80. PMID 19636951 DOI: 10.1007/S12104-009-9145-9  0.48
2009 Sinha KM, Unciuleac MC, Glickman MS, Shuman S. AdnAB: A new DSB-resecting motor-nuclease from mycobacteria Genes and Development. 23: 1423-1437. PMID 19470566 DOI: 10.1101/Gad.1805709  0.469
2009 Shuman S. DNA ligases: Progress and prospects Journal of Biological Chemistry. 284: 17365-17369. PMID 19329793 DOI: 10.1074/Jbc.R900017200  0.632
2009 Sinha KM, Glickman MS, Shuman S. Mutational analysis of mycobacterium UvrD1 identifies functional groups required for ATP hydrolysis, DNA unwinding, and chemomechanical coupling Biochemistry. 48: 4019-4030. PMID 19317511 DOI: 10.1021/Bi900103D  0.539
2009 Jain R, Shuman S. Characterization of a thermostable archaeal polynucleotide kinase homologous to human Clp1 Rna. 15: 923-931. PMID 19299550 DOI: 10.1261/Rna.1492809  0.304
2009 Wang LK, Zhu H, Shuman S. Structure-guided Mutational Analysis of the Nucleotidyltransferase Domain of Escherichia coli DNA Ligase (LigA). The Journal of Biological Chemistry. 284: 8486-94. PMID 19150981 DOI: 10.1074/Jbc.M808476200  0.484
2009 Natarajan A, Zhu H, Nair PA, Shuman S, Ghose R. Structure/function Correlations in P. aeruginosa DNA Ligase LigD Biophysical Journal. 96: 58a-59a. DOI: 10.1016/J.Bpj.2008.12.199  0.482
2009 Piserchio A, Nair PA, Shuman SS, Ghose R. Functional Dynamics in Chlorella virus DNA Ligase Biophysical Journal. 96: 322a. DOI: 10.1016/J.Bpj.2008.12.1614  0.554
2008 Sinha KM, Stephanou NC, Unciuleac MC, Glickman MS, Shuman S. Domain requirements for DNA unwinding by mycobacterial UvrD2, an essential DNA helicase. Biochemistry. 47: 9355-64. PMID 18702526 DOI: 10.1021/Bi800725Q  0.463
2008 Nandakumar J, Schwer B, Schaffrath R, Shuman S. RNA repair: an antidote to cytotoxic eukaryal RNA damage. Molecular Cell. 31: 278-86. PMID 18657509 DOI: 10.1016/J.Molcel.2008.05.019  0.3
2008 Wang LK, Nair PA, Shuman S. Structure-guided mutational analysis of the OB, HhH, and BRCT domains of Escherichia coli DNA ligase. The Journal of Biological Chemistry. 283: 23343-52. PMID 18515356 DOI: 10.1074/Jbc.M802945200  0.453
2008 Crut A, Nair PA, Koster DA, Shuman S, Dekker NH. Dynamics of phosphodiester synthesis by DNA ligase. Proceedings of the National Academy of Sciences of the United States of America. 105: 6894-9. PMID 18458338 DOI: 10.1073/Pnas.0800113105  0.607
2008 Benarroch D, Smith P, Shuman S. Characterization of a trifunctional mimivirus mRNA capping enzyme and crystal structure of the RNA triphosphatase domain. Structure (London, England : 1993). 16: 501-12. PMID 18400173 DOI: 10.1016/J.Str.2008.01.009  0.447
2008 Yakovleva L, Chen S, Hecht SM, Shuman S. Chemical and traditional mutagenesis of vaccinia DNA topoisomerase provides insights to cleavage site recognition and transesterification chemistry. The Journal of Biological Chemistry. 283: 16093-103. PMID 18367446 DOI: 10.1074/Jbc.M801595200  0.606
2008 Aniukwu J, Glickman MS, Shuman S. The pathways and outcomes of mycobacterial NHEJ depend on the structure of the broken DNA ends. Genes & Development. 22: 512-27. PMID 18281464 DOI: 10.1101/Gad.1631908  0.533
2008 Zhu H, Shuman S. Bacterial nonhomologous end joining ligases preferentially seal breaks with a 3′-OH monoribonucleotide Journal of Biological Chemistry. 283: 8331-8339. PMID 18203718 DOI: 10.1074/Jbc.M705476200  0.543
2007 Keppetipola N, Shuman S. Characterization of the 2',3' cyclic phosphodiesterase activities of Clostridium thermocellum polynucleotide kinase-phosphatase and bacteriophage lambda phosphatase. Nucleic Acids Research. 35: 7721-32. PMID 17986465 DOI: 10.1093/Nar/Gkm868  0.318
2007 Shuman S, Glickman MS. Bacterial DNA repair by non-homologous end joining. Nature Reviews. Microbiology. 5: 852-61. PMID 17938628 DOI: 10.1038/Nrmicro1768  0.54
2007 Stephanou NC, Gao F, Bongiorno P, Ehrt S, Schnappinger D, Shuman S, Glickman MS. Mycobacterial nonhomologous end joining mediates mutagenic repair of chromosomal double-strand DNA breaks. Journal of Bacteriology. 189: 5237-46. PMID 17496093 DOI: 10.1128/Jb.00332-07  0.406
2007 Keppetipola N, Nandakumar J, Shuman S. Reprogramming the tRNA-splicing activity of a bacterial RNA repair enzyme. Nucleic Acids Research. 35: 3624-30. PMID 17488852 DOI: 10.1093/Nar/Gkm110  0.334
2007 Zhu H, Shuman S. Characterization of Agrobacterium tumefaciens DNA ligases C and D Nucleic Acids Research. 35: 3631-3645. PMID 17488851 DOI: 10.1093/Nar/Gkm145  0.561
2007 Nandakumar J, Nair PA, Shuman S. Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate. Molecular Cell. 26: 257-71. PMID 17466627 DOI: 10.1016/J.Molcel.2007.02.026  0.556
2007 Sinha KM, Stephanou NC, Gao F, Glickman MS, Shuman S. Mycobacterial UvrD1 is a Ku-dependent DNA helicase that plays a role in multiple DNA repair events, including double-strand break repair. The Journal of Biological Chemistry. 282: 15114-25. PMID 17376770 DOI: 10.1074/Jbc.M701167200  0.595
2007 Tian L, Shuman S. Vaccinia topoisomerase mutants illuminate roles for Phe59, Gly73, Gln69 and Phe215. Virology. 359: 466-76. PMID 17059840 DOI: 10.1016/J.Virol.2006.08.056  0.485
2007 Benarroch D, Claverie JM, Raoult D, Shuman S. Characterization of mimivirus DNA topoisomerase IB suggests horizontal gene transfer between eukaryal viruses and bacteria. Journal of Virology. 80: 314-21. PMID 16352556 DOI: 10.1128/Jvi.80.1.314-321.2006  0.498
2006 Nandakumar J, Shuman S, Lima CD. RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward. Cell. 127: 71-84. PMID 17018278 DOI: 10.1016/J.Cell.2006.08.038  0.377
2006 Yakovleva L, Lai J, Kool ET, Shuman S. Nonpolar nucleobase analogs illuminate requirements for site-specific DNA cleavage by vaccinia topoisomerase. The Journal of Biological Chemistry. 281: 35914-21. PMID 17005552 DOI: 10.1074/Jbc.M608349200  0.573
2006 Benarroch D, Shuman S. Characterization of mimivirus NAD+-dependent DNA ligase Virology. 353: 133-143. PMID 16844179 DOI: 10.1016/J.Virol.2006.04.032  0.597
2006 Yakovleva L, Shuman S. Nucleotide misincorporation, 3′-mismatch extension, and responses to abasic sites and DNA adducts by the polymerase component of bacterial DNA ligase D Journal of Biological Chemistry. 281: 25026-25040. PMID 16816388 DOI: 10.1074/Jbc.M603302200  0.585
2006 Yakovleva L, Handy CJ, Yagi H, Sayer JM, Jerina DM, Shuman S. Intercalating polycyclic aromatic hydrocarbon-DNA adducts poison DNA religation by Vaccinia topoisomerase and act as roadblocks to digestion by exonuclease III. Biochemistry. 45: 7644-53. PMID 16768460 DOI: 10.1021/Bi060158H  0.623
2006 Zhu H, Shuman S. Substrate specificity and structure-function analysis of the 3′-phosphoesterase component of the bacterial NHEJ protein, DNA ligase D Journal of Biological Chemistry. 281: 13873-13881. PMID 16540477 DOI: 10.1074/Jbc.M600055200  0.44
2006 Akey D, Martins A, Aniukwu J, Glickman MS, Shuman S, Berger JM. Crystal structure and nonhomologous end-joining function of the ligase component of Mycobacterium DNA ligase D. The Journal of Biological Chemistry. 281: 13412-23. PMID 16476729 DOI: 10.1074/Jbc.M513550200  0.553
2006 Zhu H, Nandakumar J, Aniukwu J, Wang LK, Glickman MS, Lima CD, Shuman S. Atomic structure and nonhomologous end-joining function of the polymerase component of bacterial DNA ligase D. Proceedings of the National Academy of Sciences of the United States of America. 103: 1711-6. PMID 16446439 DOI: 10.1073/Pnas.0509083103  0.584
2006 Patel A, Shuman S, Mondragón A. Crystal structure of a bacterial type IB DNA topoisomerase reveals a preassembled active site in the absence of DNA. The Journal of Biological Chemistry. 281: 6030-7. PMID 16368685 DOI: 10.1074/Jbc.M512332200  0.597
2006 Keppetipola N, Shuman S. Mechanism of the phosphatase component of Clostridium thermocellum polynucleotide kinase-phosphatase. Rna (New York, N.Y.). 12: 73-82. PMID 16301605 DOI: 10.1261/Rna.2196406  0.333
2005 Khalid MF, Damha MJ, Shuman S, Schwer B. Structure-function analysis of yeast RNA debranching enzyme (Dbr1), a manganese-dependent phosphodiesterase. Nucleic Acids Research. 33: 6349-60. PMID 16275784 DOI: 10.1093/Nar/Gki934  0.33
2005 Moreno-Herrero F, Holtzer L, Koster DA, Shuman S, Dekker C, Dekker NH. Atomic force microscopy shows that vaccinia topoisomerase IB generates filaments on DNA in a cooperative fashion Nucleic Acids Research. 33: 5945-5953. PMID 16237128 DOI: 10.1093/Nar/Gki906  0.586
2005 Keppetipola N, Shuman S. Characterization of a thermophilic ATP-dependent DNA ligase from the euryarchaeon Pyrococcus horikoshii. Journal of Bacteriology. 187: 6902-8. PMID 16199559 DOI: 10.1128/Jb.187.20.6902-6908.2005  0.515
2005 Zhu H, Wang LK, Shuman S. Essential constituents of the 3'-phosphoesterase domain of bacterial DNA ligase D, a nonhomologous end-joining enzyme. The Journal of Biological Chemistry. 280: 33707-15. PMID 16046407 DOI: 10.1074/Jbc.M506838200  0.47
2005 Martins A, Shuman S. An end-healing enzyme from Clostridium thermocellum with 5′ kinase, 2′,3′ phosphatase, and adenylyltransferase activities Rna. 11: 1271-1280. PMID 15987807 DOI: 10.1261/Rna.2690505  0.436
2005 Li KW, Shuman S. Structure-function analysis of yeast tRNA ligase Rna. 11: 966-975. PMID 15923379 DOI: 10.1261/Rna.2170305  0.339
2005 Zhu H, Shuman S. Novel 3′-ribonuclease and 3′-phosphatase activities of the bacterial non-homologous end-joining protein, DNA ligase D Journal of Biological Chemistry. 280: 25973-25981. PMID 15897197 DOI: 10.1074/Jbc.M504002200  0.545
2005 Tian L, Claeboe CD, Hecht SM, Shuman S. Mechanistic plasticity of DNA topoisomerase IB: phosphate electrostatics dictate the need for a catalytic arginine. Structure (London, England : 1993). 13: 513-20. PMID 15837190 DOI: 10.1016/J.Str.2005.02.001  0.588
2005 Koster DA, Croquette V, Dekker C, Shuman S, Dekker NH. Friction and torque govern the relaxation of DNA supercoils by eukaryotic topoisomerase IB. Nature. 434: 671-4. PMID 15800630 DOI: 10.1038/Nature03395  0.599
2005 Gong C, Bongiorno P, Martins A, Stephanou NC, Zhu H, Shuman S, Glickman MS. Mechanism of nonhomologous end-joining in mycobacteria: a low-fidelity repair system driven by Ku, ligase D and ligase C. Nature Structural & Molecular Biology. 12: 304-12. PMID 15778718 DOI: 10.1038/Nsmb915  0.553
2005 Zhu H, Shuman S. Structure-guided mutational analysis of the nucleotidyltransferase domain of Escherichia coli NAD+-dependent DNA ligase (LigA) Journal of Biological Chemistry. 280: 12137-12144. PMID 15671015 DOI: 10.1074/Jbc.M413685200  0.418
2005 Zhu H, Shuman S. A primer-dependent polymerase function of Pseudomonas aeruginosa ATP-dependent DNA ligase (LigD) Journal of Biological Chemistry. 280: 418-427. PMID 15520014 DOI: 10.1074/Jbc.M410110200  0.63
2004 Shuman S, Lima CD. The polynucleotide ligase and RNA capping enzyme superfamily of covalent nucleotidyltransferases. Current Opinion in Structural Biology. 14: 757-64. PMID 15582400 DOI: 10.1016/J.Sbi.2004.10.006  0.485
2004 Nandakumar J, Shuman S. How an RNA ligase discriminates RNA versus DNA damage. Molecular Cell. 16: 211-21. PMID 15494308 DOI: 10.1016/J.Molcel.2004.09.022  0.409
2004 Martins A, Shuman S. An RNA ligase from Deinococcus radiodurans Journal of Biological Chemistry. 279: 50654-50661. PMID 15333634 DOI: 10.1074/Jbc.M407657200  0.356
2004 Shuman S. NAD+ specificity of bacterial DNA ligase revealed Structure. 12: 1335-1336. PMID 15296724 DOI: 10.1016/J.Str.2004.07.002  0.571
2004 Nandakumar J, Ho CK, Lima CD, Shuman S. RNA substrate specificity and structure-guided mutational analysis of bacteriophage T4 RNA ligase 2. The Journal of Biological Chemistry. 279: 31337-47. PMID 15084599 DOI: 10.1074/Jbc.M402394200  0.321
2004 Zhu H, Yin S, Shuman S. Characterization of polynucleotide kinase/phosphatase enzymes from Mycobacteriophages omega and Cjw1 and vibriophage KVP40. The Journal of Biological Chemistry. 279: 26358-69. PMID 15056675 DOI: 10.1074/Jbc.M403200200  0.361
2004 Yakovleva L, Handy CJ, Sayer JM, Pirrung M, Jerina DM, Shuman S. Benzo[c]phenanthrene adducts and nogalamycin inhibit DNA transesterification by vaccinia topoisomerase. The Journal of Biological Chemistry. 279: 23335-42. PMID 15044474 DOI: 10.1074/Jbc.M401203200  0.572
2004 Gong C, Martins A, Bongiorno P, Glickman M, Shuman S. Biochemical and genetic analysis of the four DNA ligases of mycobacteria. The Journal of Biological Chemistry. 279: 20594-606. PMID 14985346 DOI: 10.1074/Jbc.M401841200  0.496
2004 Yin S, Kiong Ho C, Miller ES, Shuman S. Characterization of bacteriophage KVP40 and T4 RNA ligase 2. Virology. 319: 141-51. PMID 14967495 DOI: 10.1016/J.Virol.2003.10.037  0.3
2004 Ho CK, Wang LK, Lima CD, Shuman S. Structure and mechanism of RNA ligase. Structure (London, England : 1993). 12: 327-39. PMID 14962393 DOI: 10.1016/J.Str.2004.01.011  0.317
2004 Liao S, Mao C, Birktoft JJ, Shuman S, Seeman NC. Resolution of undistorted symmetric immobile DNA junctions by vaccinia topoisomerase I. Biochemistry. 43: 1520-31. PMID 14769028 DOI: 10.1021/Bi0358061  0.559
2004 Tian L, Claeboe CD, Hecht SM, Shuman S. Remote phosphate contacts trigger assembly of the active site of DNA topoisomerase IB. Structure (London, England : 1993). 12: 31-40. PMID 14725763 DOI: 10.1016/J.Str.2003.11.025  0.534
2004 Odell M, Malinina L, Sriskanda V, Teplova M, Shuman S. Analysis of the DNA joining repertoire of Chlorella virus DNA ligase and a new crystal structure of the ligase-adenylate intermediate. Nucleic Acids Research. 31: 5090-100. PMID 12930960 DOI: 10.1093/Nar/Gkg665  0.577
2003 Tian L, Claeboe CD, Hecht SM, Shuman S. Guarding the genome: electrostatic repulsion of water by DNA suppresses a potent nuclease activity of topoisomerase IB. Molecular Cell. 12: 199-208. PMID 12887905 DOI: 10.1016/S1097-2765(03)00263-6  0.611
2003 Sawaya R, Shuman S. Mutational analysis of the guanylyltransferase component of Mammalian mRNA capping enzyme. Biochemistry. 42: 8240-9. PMID 12846573 DOI: 10.1021/Bi034396D  0.322
2003 Wang LK, Ho CK, Pei Y, Shuman S. Mutational analysis of bacteriophage T4 RNA ligase 1. Different functional groups are required for the nucleotidyl transfer and phosphodiester bond formation steps of the ligation reaction. The Journal of Biological Chemistry. 278: 29454-62. PMID 12766156 DOI: 10.1074/Jbc.M304320200  0.345
2003 Yin S, Ho CK, Shuman S. Structure-function analysis of T4 RNA ligase 2. The Journal of Biological Chemistry. 278: 17601-8. PMID 12611899 DOI: 10.1074/Jbc.M300817200  0.385
2003 Tian L, Sayer JM, Kroth H, Kalena G, Jerina DM, Shuman S. Benzo[a]pyrene-dG adduct interference illuminates the interface of vaccinia topoisomerase with the DNA minor groove. The Journal of Biological Chemistry. 278: 9905-11. PMID 12524450 DOI: 10.1074/Jbc.M212468200  0.578
2002 Wang LK, Lima CD, Shuman S. Structure and mechanism of T4 polynucleotide kinase: an RNA repair enzyme. The Embo Journal. 21: 3873-80. PMID 12110598 DOI: 10.1093/Emboj/Cdf397  0.357
2002 Gong C, Shuman S. Chlorella virus RNA triphosphatase. Mutational analysis and mechanism of inhibition by tripolyphosphate. The Journal of Biological Chemistry. 277: 15317-24. PMID 11844801 DOI: 10.1074/Jbc.M200532200  0.331
2002 Sriskanda V, Shuman S. Role of nucleotidyltransferase motifs I, III and IV in the catalysis of phosphodiester bond formation by Chlorella virus DNA ligase Nucleic Acids Research. 30: 903-911. PMID 11842101 DOI: 10.1093/Nar/30.4.903  0.624
2002 Krogh BO, Shuman S. A poxvirus-like type IB topoisomerase family in bacteria Proceedings of the National Academy of Sciences of the United States of America. 99: 1853-1858. PMID 11830640 DOI: 10.1073/Pnas.032613199  0.535
2002 Sriskanda V, Shuman S. Conserved residues in domain Ia are required for the reaction of Escherichia coli DNA ligase with NAD+ Journal of Biological Chemistry. 277: 9695-9700. PMID 11781321 DOI: 10.1074/Jbc.M111164200  0.586
2002 Krogh BO, Shuman S. Proton relay mechanism of general acid catalysis by DNA topoisomerase IB Journal of Biological Chemistry. 277: 5711-5714. PMID 11756402 DOI: 10.1074/Jbc.C100681200  0.532
2002 Sriskanda V, Shuman S. Role of nucleotidyl transferase motif V in strand joining by Chlorella virus DNA ligase Journal of Biological Chemistry. 277: 9661-9667. PMID 11751916 DOI: 10.1074/Jbc.M110613200  0.625
2002 Odell M, Sriskanda V, Shuman S, Nikolov DB. Crystal structure of eukaryotic DNA ligase-adenylate illuminates the mechanism of nick sensing and strand joining. Molecular Cell. 6: 1183-93. PMID 11106756 DOI: 10.1016/S1097-2765(00)00115-5  0.526
2001 Sriskanda V, Shuman S. A second NAD+-dependent DNA ligase (LigB) in Escherichia coli Nucleic Acids Research. 29: 4930-4934. PMID 11812821 DOI: 10.1093/Nar/29.24.4930  0.621
2001 Sriskanda V, Moyer RW, Shuman S. NAD+-dependent DNA ligase encoded by a eukaryotic virus. The Journal of Biological Chemistry. 276: 36100-9. PMID 11459847 DOI: 10.1074/jbc.M105643200  0.47
2001 Krogh BO, Shuman S. Vaccinia topoisomerase mutants illuminate conformational changes during closure of the protein clamp and assembly of a functional active site. The Journal of Biological Chemistry. 276: 36091-9. PMID 11441004 DOI: 10.1074/Jbc.M102609200  0.464
2001 Krogh BO, Claeboe CD, Hecht SM, Shuman S. Effect of 2'-5' phosphodiesters on DNA transesterification by vaccinia topoisomerase. The Journal of Biological Chemistry. 276: 20907-12. PMID 11399773 DOI: 10.1074/Jbc.M102312200  0.663
2001 Shuman S. Analysis of topoisomerase-DNA interactions by electrophoretic mobility shift assay Methods in Molecular Biology (Clifton, N.J.). 95: 65-74. PMID 11089220 DOI: 10.1385/1-59259-057-8:65  0.464
2000 Cheng C, Shuman S. Recombinogenic flap ligation pathway for intrinsic repair of topoisomerase IB-induced double-strand breaks. Molecular and Cellular Biology. 20: 8059-68. PMID 11027276 DOI: 10.1128/Mcb.20.21.8059-8068.2000  0.781
2000 Martins A, Shuman S. Mechanism of phosphoanhydride cleavage by baculovirus phosphatase Journal of Biological Chemistry. 275: 35070-35076. PMID 10954717 DOI: 10.1074/Jbc.M005748200  0.308
2000 Woodfield G, Cheng C, Shuman S, Burgin AB. Vaccinia topoisomerase and Cre recombinase catalyze direct ligation of activated DNA substrates containing a 3'-para-nitrophenyl phosphate ester. Nucleic Acids Research. 28: 3323-31. PMID 10954601 DOI: 10.1093/nar/28.17.3323  0.798
2000 Krogh BO, Shuman S. Catalytic mechanism of DNA topoisomerase IB. Molecular Cell. 5: 1035-41. PMID 10911997 DOI: 10.1016/S1097-2765(00)80268-3  0.567
2000 Sekiguchi J, Cheng C, Shuman S. Resolution of a Holliday junction by vaccinia topoisomerase requires a spacer DNA segment 3' of the CCCTT/ cleavage sites. Nucleic Acids Research. 28: 2658-63. PMID 10908320 DOI: 10.1093/Nar/28.14.2658  0.698
2000 Klemm M, Cheng C, Cassell G, Shuman S, Segall AM. Peptide inhibitors of DNA cleavage by tyrosine recombinases and topoisomerases Journal of Molecular Biology. 299: 1203-1216. PMID 10873446 DOI: 10.1006/Jmbi.2000.3829  0.737
2000 Sriskanda V, Kelman Z, Hurwitz J, Shuman S. Characterization of an ATP-dependent DNA ligase from the the thermophilic archaeon Methanobacterium thermoautotrophicum Nucleic Acids Research. 28: 2221-2228. PMID 10871342 DOI: 10.1093/Nar/28.11.2221  0.59
2000 Krogh BO, Shuman S. DNA strand transfer catalyzed by vaccinia topoisomerase: peroxidolysis and hydroxylaminolysis of the covalent protein-DNA intermediate. Biochemistry. 39: 6422-32. PMID 10828956 DOI: 10.1021/Bi000184U  0.613
2000 Stivers JT, Jagadeesh GJ, Nawrot B, Stec WJ, Shuman S. Stereochemical outcome and kinetic effects of Rp- and Sp-phosphorothioate substitutions at the cleavage site of vaccinia type I DNA topoisomerase. Biochemistry. 39: 5561-72. PMID 10820030 DOI: 10.1021/Bi992429C  0.464
2000 Cheng C, Shuman S. DNA strand transfer catalyzed by vaccinia topoisomerase: ligation of DNAs containing a 3' mononucleotide overhang. Nucleic Acids Research. 28: 1893-8. PMID 10756188 DOI: 10.1093/Nar/28.9.1893  0.789
1999 Cheng C, Shuman S. Site-specific DNA transesterification by vaccinia topoisomerase: role of specific phosphates and nucleosides. Biochemistry. 38: 16599-612. PMID 10600122 DOI: 10.1021/Bi992001D  0.779
1999 Krogh BO, Cheng C, Burgin A, Shuman S. Melanoplus sanguinipes entomopoxvirus DNA topoisomerase: site-specific DNA transesterification and effects of 5'-bridging phosphorothiolates. Virology. 264: 441-51. PMID 10562506 DOI: 10.1006/Viro.1999.0022  0.782
1999 Pei Y, Ho CK, Schwer B, Shuman S. Mutational analyses of yeast RNA triphosphatases highlight a common mechanism of metal-dependent NTP hydrolysis and a means of targeting enzymes to Pre-mRNAs in vivo by fusion to the guanylyltransferase component of the capping apparatus Journal of Biological Chemistry. 274: 28865-28874. PMID 10506129 DOI: 10.1074/Jbc.274.41.28865  0.336
1999 Sriskanda V, Schwer B, Ho KC, Shuman S. Mutational analysis of Escherichia coli DNA ligase identifies amino acids required for nick-ligation in vitro and for in vivo complementation of the growth of yeast cells deleted for CDC9 and LIG4 Nucleic Acids Research. 27: 3953-3963. PMID 10497258 DOI: 10.1093/Nar/27.20.3953  0.549
1999 Odell M, Shuman S. Footprinting of Chlorella virus DNA ligase bound at a nick in duplex DNA Journal of Biological Chemistry. 274: 14032-14039. PMID 10318816 DOI: 10.1074/Jbc.274.20.14032  0.646
1999 Martins A, Gross CH, Shuman S. Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase I, a DNA-dependent ATPase of the DExH box family. Journal of Virology. 73: 1302-8. PMID 9882335 DOI: 10.1128/Jvi.73.2.1302-1308.1999  0.393
1999 Ho CK, Pei Y, Shuman S. Yeast and viral RNA 5' triphosphatases comprise a new nucleoside triphosphatase family. The Journal of Biological Chemistry. 273: 34151-6. PMID 9852075 DOI: 10.1074/Jbc.273.51.34151  0.349
1998 Sriskanda V, Shuman S. Mutational analysis of Chlorella virus DNA ligase: Catalytic roles of domain I and motif VI Nucleic Acids Research. 26: 4618-4625. PMID 9753729 DOI: 10.1093/Nar/26.20.4618  0.534
1998 Shuman S. Vaccinia virus DNA topoisomerase: A model eukaryotic type IB enzyme Biochimica Et Biophysica Acta - Gene Structure and Expression. 1400: 321-337. PMID 9748643 DOI: 10.1016/S0167-4781(98)00144-4  0.632
1998 Gross CH, Shuman S. Characterization of a baculovirus-encoded RNA 5'-triphosphatase Journal of Virology. 72: 7057-7063. PMID 9696798 DOI: 10.1128/Jvi.72.9.7057-7063.1998  0.317
1998 Sriskanda V, Shuman S. Specificity and fidelity of strand joining by Chlorella virus DNA ligase Nucleic Acids Research. 26: 3536-3541. PMID 9671815 DOI: 10.1093/Nar/26.15.3536  0.592
1998 Shuman S. Polynucleotide ligase activity of eukaryotic topoisomerase I Molecular Cell. 1: 741-748. PMID 9660957 DOI: 10.1016/S1097-2765(00)80073-8  0.479
1998 Cheng C, Shuman S. A catalytic domain of eukaryotic DNA topoisomerase I. The Journal of Biological Chemistry. 273: 11589-95. PMID 9565576 DOI: 10.1074/Jbc.273.19.11589  0.798
1998 Cheng C, Kussie P, Pavletich N, Shuman S. Conservation of structure and mechanism between eukaryotic topoisomerase I and site-specific recombinases Cell. 92: 841-850. PMID 9529259 DOI: 10.1016/S0092-8674(00)81411-7  0.741
1998 Deng L, Shuman S. Vaccinia NPH-I, a DExH-box ATPase, is the energy coupling factor for mRNA transcription termination Genes and Development. 12: 538-546. PMID 9472022 DOI: 10.1101/Gad.12.4.538  0.313
1998 Sriskanda V, Shuman S. Chlorella virus DNA ligase: Nick recognition and mutational analysis Nucleic Acids Research. 26: 525-531. PMID 9421510 DOI: 10.1093/Nar/26.2.502  0.666
1998 Wittschieben J, Petersen BO, Shuman S. Replacement of the active site tyrosine of vaccinia DNA topoisomerase by glutamate, cysteine or histidine converts the enzyme into a site-specific endonuclease. Nucleic Acids Research. 26: 490-6. PMID 9421505 DOI: 10.1093/Nar/26.2.490  0.603
1997 Sekiguchi J, Shuman S. Site-specific ribonuclease activity of eukaryotic DNA topoisomerase I Molecular Cell. 1: 89-97. PMID 9659906 DOI: 10.1016/S1097-2765(00)80010-6  0.582
1997 Sekiguchi J, Shuman S. Nick sensing by vaccinia virus DNA ligase requires a 5' phosphate at the nick and occupancy of the adenylate binding site on the enzyme Journal of Virology. 71: 9679-9684. PMID 9371633 DOI: 10.1128/Jvi.71.12.9679-9684.1997  0.658
1997 Sekiguchi J, Shuman S. Novobiocin inhibits vaccinia virus replication by blocking virus assembly Virology. 235: 129-137. PMID 9300044 DOI: 10.1006/Viro.1997.8684  0.361
1997 Sekiguchi J, Shuman S. Mutational analysis of vaccinia virus topoisomerase identifies residues involved in DNA binding Nucleic Acids Research. 25: 3649-3656. PMID 9278486 DOI: 10.1093/Nar/25.18.3649  0.646
1997 Wang SP, Deng L, Ho CK, Shuman S. Phylogeny of mRNA capping enzymes. Proceedings of the National Academy of Sciences of the United States of America. 94: 9573-8. PMID 9275164 DOI: 10.1073/Pnas.94.18.9573  0.378
1997 Wittschieben J, Shuman S. Mechanism of DNA transesterification by vaccinia topoisomerase: Catalytic contributions of essential residues Arg-130, Gly-132, Tyr-136 and Lys-167 Nucleic Acids Research. 25: 3001-3008. PMID 9224599 DOI: 10.1093/Nar/25.15.3001  0.602
1997 Sekiguchi J, Shuman S. Ligation of RNA-containing duplexes by vaccinia DNA ligase Biochemistry. 36: 9073-9079. PMID 9220997 DOI: 10.1021/Bi970705M  0.569
1997 Wang LK, Wittschieben J, Shuman S. Mutational analysis of 26 residues of vaccinia DNA topoisomerase identifies Ser-204 as important for DNA binding and cleavage. Biochemistry. 36: 7944-50. PMID 9201940 DOI: 10.1021/Bi970498Q  0.652
1997 Sekiguchi J, Cheng C, Shuman S. Kinetic analysis of DNA and RNA strand transfer reactions catalyzed by vaccinia topoisomerase. The Journal of Biological Chemistry. 272: 15721-8. PMID 9188465 DOI: 10.1074/Jbc.272.25.15721  0.786
1997 Petersen B, Shuman S. DNA strand transfer reactions catalyzed by vaccinia topoisomerase: Hydrolysis and glycerololysis of the covalent protein-DNA intermediate Nucleic Acids Research. 25: 2091-2097. PMID 9153307 DOI: 10.1093/Nar/25.11.2091  0.651
1997 Petersen BO, Hall RL, Moyer RW, Shuman S. Characterization of a DNA topoisomerase encoded by Amsacta moore entomopoxvirus. Virology. 230: 197-206. PMID 9143275 DOI: 10.1006/Viro.1997.8495  0.578
1997 Wang LK, Shuman S. Deletions at the carboxyl terminus of vaccinia DNA topoisomerase affect DNA binding and enhance distributivity in DNA relaxation Biochemistry. 36: 3909-3916. PMID 9092821 DOI: 10.1021/Bi962754P  0.651
1997 Cheng C, Wang LK, Sekiguchi J, Shuman S. Mutational analysis of 39 residues of vaccinia DNA topoisomerase identifies Lys-220, Arg-223, and Asn-228 as important for covalent catalysis. The Journal of Biological Chemistry. 272: 8263-9. PMID 9079646 DOI: 10.1074/Jbc.272.13.8263  0.756
1997 Cheng C, Shuman S. Characterization of an ATP-dependent DNA ligase encoded by Haemophilus influenzae. Nucleic Acids Research. 25: 1369-74. PMID 9060431 DOI: 10.1093/Nar/25.7.1369  0.766
1997 Ho CK, Van Etten JL, Shuman S. Characterization of an ATP-dependent DNA ligase encoded by Chlorella virus PBCV-1. Journal of Virology. 71: 1931-7. PMID 9032324 DOI: 10.1128/Jvi.71.3.1931-1937.1997  0.631
1997 Petersen B, Shuman S. Histidine 265 is important for covalent catalysis by vaccinia topoisomerase and is conserved in all eukaryotic type I enzymes Journal of Biological Chemistry. 272: 3891-3896. PMID 9020090 DOI: 10.1074/Jbc.272.7.3891  0.546
1997 Sekiguchi J, Shuman S. Domain structure of vaccinia DNA ligase Nucleic Acids Research. 25: 727-734. PMID 9016621 DOI: 10.1093/Nar/25.4.727  0.493
1996 Gross CH, Shuman S. Vaccinia virions lacking the RNA helicase nucleoside triphosphate phosphohydrolase II are defective in early transcription Journal of Virology. 70: 8549-8557. PMID 8970979  0.349
1996 Petersen BO, Wittschieben J, Shuman S. Mutations within a conserved region of vaccinia topoisomerase affect the DNA cleavage-religation equilibrium. Journal of Molecular Biology. 263: 181-95. PMID 8913300 DOI: 10.1006/Jmbi.1996.0568  0.452
1996 Shuman S. Closing the gap on DNA ligase Structure. 4: 653-656. PMID 8805556 DOI: 10.1016/S0969-2126(96)00070-6  0.503
1996 Ho CK, Van Etten JL, Shuman S. Expression and characterization of an RNA capping enzyme encoded by Chlorella virus PBCV-1. Journal of Virology. 70: 6658-64. PMID 8794301 DOI: 10.1128/Jvi.70.10.6658-6664.1996  0.332
1996 Sekiguchi J, Shuman S. Covalent DNA binding by vaccinia topoisomerase results in unpairing of the thymine base 5' of the scissile bond Journal of Biological Chemistry. 271: 19436-19442. PMID 8702632 DOI: 10.1074/Jbc.271.32.19436  0.591
1996 Sekiguchi J, Shuman S. Identification of contacts between topoisomerase I and its target DNA by site-specific photocrosslinking Embo Journal. 15: 3448-3457. PMID 8670847 DOI: 10.1002/J.1460-2075.1996.Tb00711.X  0.624
1996 Gross CH, Shuman S. Vaccinia virus RNA helicase: Nucleic acid specificity in duplex unwinding Journal of Virology. 70: 2615-2619. PMID 8642695  0.493
1996 Ho CK, Shuman S. Physical and functional characterization of the double-stranded RNA binding protein encoded by the vaccinia virus E3 gene Virology. 217: 272-284. PMID 8599212 DOI: 10.1006/Viro.1996.0114  0.306
1996 Sekiguchi J, Seeman NC, Shuman S. Resolution of Holliday junctions by eukaryotic DNA topoisomerase I. Proceedings of the National Academy of Sciences of the United States of America. 93: 785-9. PMID 8570635 DOI: 10.1073/Pnas.93.2.785  0.585
1996 Sekiguchi J, Stivers JT, Mildvan AS, Shuman S. Mechanism of inhibition of vaccinia DNA topoisomerase by novobiocin and coumermycin. The Journal of Biological Chemistry. 271: 2313-22. PMID 8567695 DOI: 10.1074/Jbc.271.4.2313  0.52
1995 Shuman S, Schwer B. RNA capping enzyme and DNA ligase: A superfamily of covalent nucleotidyl transferases Molecular Microbiology. 17: 405-410. PMID 8559059 DOI: 10.1111/J.1365-2958.1995.Mmi_17030405.X  0.466
1995 Shuman S. Vaccinia virus DNA ligase: Specificity, fidelity, and inhibition Biochemistry. 34: 16138-16147. PMID 8519771 DOI: 10.1021/Bi00049A029  0.67
1995 Sekiguchi J, Shuman S. Proteolytic footprinting of vaccinia topoisomerase bound to DNA Journal of Biological Chemistry. 270: 11636-11645. PMID 7744804 DOI: 10.1074/Jbc.270.19.11636  0.608
1995 Gross CH, Shuman S. Mutational analysis of vaccinia virus nucleoside triphosphate phosphohydrolase II, a DExH box RNA helicase Journal of Virology. 69: 4727-4736. PMID 7609038  0.307
1995 Cong P, Shuman S. Mutational analysis of mRNA capping enzyme identifies amino acids involved in GTP binding, enzyme-guanylate formation, and GMP transfer to RNA Molecular and Cellular Biology. 15: 6222-6231. PMID 7565775 DOI: 10.1128/Mcb.15.11.6222  0.366
1994 Stivers JT, Shuman S, Mildvan AS. Vaccinia DNA topoisomerase I: single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions. Biochemistry. 33: 327-39. PMID 8286354 DOI: 10.1021/Bi00167A043  0.606
1994 Schwer B, Shuman S. Mutational analysis of yeast mRNA capping enzyme Proceedings of the National Academy of Sciences of the United States of America. 91: 4328-4332. PMID 8183907 DOI: 10.1073/Pnas.91.10.4328  0.393
1994 Shuman S, Liu Y, Schwer B. Covalent catalysis in nucleotidyl transfer reactions: Essential motifs in Saccharomyces cerevisiae RNA capping enzyme are conserved in Schizosaccharomyces pombe and viral capping enzymes and among polynucleotide ligases Proceedings of the National Academy of Sciences of the United States of America. 91: 12046-12050. PMID 7991582 DOI: 10.1073/Pnas.91.25.12046  0.357
1994 Stivers JT, Shuman S, Mildvan AS. Vaccinia DNA topoisomerase I: kinetic evidence for general acid-base catalysis and a conformational step. Biochemistry. 33: 15449-58. PMID 7803409 DOI: 10.1021/Bi00255A027  0.372
1992 Hagler J, Shuman S. Structural analysis of ternary complexes of vaccinia RNA polymerase Proceedings of the National Academy of Sciences of the United States of America. 89: 10099-10103. PMID 1438198  0.509
1992 Hagler J, Shuman S. Ternary complex formation by vaccinia virus RNA polymerase at an early viral promoter: Analysis by native gel electrophoresis Journal of Virology. 66: 2982-2989. PMID 1373199  0.39
1991 Shuman S. Recombination mediated by vaccinia virus DNA topoisomerase I in Escherichia coli is sequence specific Proceedings of the National Academy of Sciences of the United States of America. 88: 10104-10108. PMID 1658796 DOI: 10.1073/Pnas.88.22.10104  0.639
1990 Morham SG, Shuman S. Phenotypic selection and characterization of mutant alleles of a eukaryotic DNA topoisomerase I Genes and Development. 4: 515-524. PMID 2163340  0.375
1989 Shuman S, Kane EM, Morham SG. Mapping the active-site tyrosine of vaccinia virus DNA topoisomerase I. Proceedings of the National Academy of Sciences of the United States of America. 86: 9793-7. PMID 2557629 DOI: 10.1073/Pnas.86.24.9793  0.609
1989 Shuman S. Vaccinia DNA topoisomerase I promotes illegitimate recombination in Escherichia coli Proceedings of the National Academy of Sciences of the United States of America. 86: 3489-3493. PMID 2542933 DOI: 10.1073/Pnas.86.10.3489  0.544
1989 Shuman S, Golder M, Moss B. Insertional mutagenesis of the vaccinia virus gene encoding a type I DNA topoisomerase: evidence that the gene is essential for virus growth. Virology. 170: 302-6. PMID 2541548 DOI: 10.1016/0042-6822(89)90384-X  0.319
1987 Shuman S, Moss B. Identification of a vaccinia virus gene encoding a type I DNA topoisomerase Proceedings of the National Academy of Sciences of the United States of America. 84: 7478-7482. PMID 2823264 DOI: 10.1073/Pnas.84.21.7478  0.375
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