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Siyuan Zhang - Publications

Affiliations: 
2007-2012 Molecular and Cellular Oncology University of Texas MD Anderson Cancer Center, Houston, TX, United States 
 2012- Biological Sciences University of Notre Dame, Notre Dame, IN, United States 
Website:
https://biology.nd.edu/people/siyuan-zhang/
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65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Aleksandrovic E, Zhang S, Yu D. From pre-clinical to translational brain metastasis research: current challenges and emerging opportunities. Clinical & Experimental Metastasis. PMID 38430319 DOI: 10.1007/s10585-024-10271-9  0.783
2024 Zhao H, Zhao Y, Zhang S, Wang Z, Yu W, Dong N, Yang X, Zhang X, Sun Q, Hao X, Ren X. Effects of immunogenic cell death-inducing chemotherapeutics on the immune cell activation and tertiary lymphoid structure formation in melanoma. Frontiers in Immunology. 15: 1302751. PMID 38384466 DOI: 10.3389/fimmu.2024.1302751  0.344
2023 Zhao Y, Liu Z, Liu G, Zhang Y, Liu S, Gan D, Chang W, Peng X, Sung ES, Gilbert K, Zhu Y, Wang X, Zeng Z, Baldwin H, Ren G, ... ... Zhang S, et al. Neutrophils resist ferroptosis and promote breast cancer metastasis through aconitate decarboxylase 1. Cell Metabolism. 35: 1688-1703.e10. PMID 37793345 DOI: 10.1016/j.cmet.2023.09.004  0.691
2023 Zhu J, Wang Y, Chang WY, Malewska A, Napolitano F, Gahan JC, Unni N, Zhao M, Wu F, Yue L, Guo L, Zhao Z, Chen DZ, Hannan R, Zhang S, et al. Mapping Cell-to-cell Interactions from Spatially Resolved Transcriptomics Data. Biorxiv : the Preprint Server For Biology. PMID 37781617 DOI: 10.1101/2023.09.18.558298  0.319
2023 Shin J, Kim B, Lager TW, Mejia F, Guldner I, Conner C, Zhang S, Panopoulos AD, Bilgicer B. A nanotherapeutic approach to selectively eliminate metastatic breast cancer cells by targeting cell surface GRP78. Nanoscale. PMID 37526009 DOI: 10.1039/d3nr00800b  0.785
2023 Chan KI, Zhang S, Li G, Xu Y, Cui L, Wang Y, Su H, Tan W, Zhong Z. MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products. Aging and Disease. PMID 37450923 DOI: 10.14336/AD.2023.0520  0.346
2023 Palakurthi B, Fross SR, Guldner IH, Aleksandrovic E, Liu X, Martino AK, Wang Q, Neff RA, Golomb SM, Lewis C, Peng Y, Howe EN, Zhang S. Targeting CXCL16 and STAT1 augments immune checkpoint blockade therapy in triple-negative breast cancer. Nature Communications. 14: 2109. PMID 37055410 DOI: 10.1038/s41467-023-37727-y  0.761
2023 Peng B, Zhang SY, Chan KI, Zhong ZF, Wang YT. Novel Anti-Cancer Products Targeting AMPK: Natural Herbal Medicine against Breast Cancer. Molecules (Basel, Switzerland). 28. PMID 36677797 DOI: 10.3390/molecules28020740  0.364
2022 Li D, Wang C, Ni Y, Liu Y, Wang W, Zhang S, Chang HC, Senapati S. Development of a Multi-target Protein Biomarker Assay for Circulating Tumor Cells. Methods in Molecular Biology (Clifton, N.J.). 2394: 3-18. PMID 35094318 DOI: 10.1007/978-1-0716-1811-0_1  0.656
2021 Bahcecioglu G, Yue X, Howe E, Guldner I, Stack MS, Nakshatri H, Zhang S, Zorlutuna P. Aged Breast Extracellular Matrix Drives Mammary Epithelial Cells to an Invasive and Cancer-Like Phenotype. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2100128. PMID 34617419 DOI: 10.1002/advs.202100128  0.816
2021 Guldner IH, Golomb SM, Wang Q, Wang E, Zhang S. Isolation of mouse brain-infiltrating leukocytes for single cell profiling of epitopes and transcriptomes. Star Protocols. 2: 100537. PMID 34036283 DOI: 10.1016/j.xpro.2021.100537  0.784
2021 Kim J, Wang Q, Zhang S, Yoon S. Compressed sensing-based super-resolution ultrasound imaging for faster acquisition and high quality images. Ieee Transactions On Bio-Medical Engineering. PMID 33793396 DOI: 10.1109/TBME.2021.3070487  0.516
2021 Liu Y, Yang J, Shi Z, Tan X, Jin N, O'Brien C, Ott C, Grisoli A, Lee E, Volk K, Conroy M, Franz E, Bryant A, Campbell L, Crowley B, ... ... Zhang S, et al. In vivo selection of highly metastatic human ovarian cancer sublines reveals role for AMIGO2 in intra-peritoneal metastatic regulation. Cancer Letters. PMID 33524500 DOI: 10.1016/j.canlet.2021.01.024  0.817
2020 Edwards DN, Ngwa VM, Raybuck AL, Wang S, Hwang Y, Kim LC, Cho SH, Paik Y, Wang Q, Zhang S, Manning HC, Rathmell JC, Cook RS, Boothby MR, Chen J. Selective glutamine metabolism inhibition in tumor cells improves anti-tumor T lymphocyte activity in triple-negative breast cancer. The Journal of Clinical Investigation. PMID 33320840 DOI: 10.1172/JCI140100  0.67
2020 Golomb SM, Guldner IH, Zhao A, Wang Q, Palakurthi B, Aleksandrovic EA, Lopez JA, Lee SW, Yang K, Zhang S. Multi-modal Single-Cell Analysis Reveals Brain Immune Landscape Plasticity during Aging and Gut Microbiota Dysbiosis. Cell Reports. 33: 108438. PMID 33264626 DOI: 10.1016/j.celrep.2020.108438  0.753
2020 Guldner IH, Wang Q, Yang L, Golomb SM, Zhao Z, Lopez JA, Brunory A, Howe EN, Zhang Y, Palakurthi B, Barron M, Gao H, Xuei X, Liu Y, Li J, ... ... Zhang S, et al. CNS-Native Myeloid Cells Drive Immune Suppression in the Brain Metastatic Niche through Cxcl10. Cell. PMID 33113353 DOI: 10.1016/j.cell.2020.09.064  0.772
2020 Wang S, Raybuck A, Shiuan E, Cho SH, Wang Q, Brantley-Sieders DM, Edwards D, Allaman MM, Nathan J, Wilson KT, DeNardo D, Zhang S, Cook R, Boothby M, Chen J. Selective inhibition of mTORC1 in tumor vessels increases antitumor immunity. Jci Insight. 5. PMID 32759497 DOI: 10.1172/Jci.Insight.139237  0.651
2020 Howe EN, Burnette MD, Justice ME, Schnepp PM, Hedrick V, Clancy JW, Guldner IH, Lamere AT, Li J, Aryal UK, D'Souza-Schorey C, Zartman JJ, Zhang S. Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth. Nature Communications. 11: 3017. PMID 32541798 DOI: 10.1038/S41467-020-16832-2  0.802
2020 Conner C, Lager TW, Guldner IH, Wu MZ, Hishida Y, Hishida T, Ruiz S, Yamasaki AE, Gilson RC, Belmonte JCI, Gray PC, Kelber JA, Zhang S, Panopoulos AD. Cell surface GRP78 promotes stemness in normal and neoplastic cells. Scientific Reports. 10: 3474. PMID 32103065 DOI: 10.1038/S41598-020-60269-Y  0.803
2020 Asem M, Young AM, Oyama C, Claure De La Zerda AG, Liu Y, Yang J, Hilliard TS, Johnson J, Harper EI, Guldner I, Zhang S, Page-Mayberry TM, Kaliney WJ, Stack MS. Host Wnt5a Potentiates Microenvironmental Regulation of Ovarian Cancer Metastasis. Cancer Research. PMID 31932454 DOI: 10.1158/0008-5472.Can-19-1601  0.792
2019 Zhang S, Tang Z, Qing B, Tang R, Duan Q, Ding S, Deng D. Valproic acid promotes the epithelial-to-mesenchymal transition of breast cancer cells through stabilization of Snail and transcriptional upregulation of Zeb1. European Journal of Pharmacology. 172745. PMID 31639340 DOI: 10.1016/j.ejphar.2019.172745  0.36
2019 Wang Q, Guldner IH, Golomb SM, Sun L, Harris JA, Lu X, Zhang S. Single-cell profiling guided combinatorial immunotherapy for fast-evolving CDK4/6 inhibitor-resistant HER2-positive breast cancer. Nature Communications. 10: 3817. PMID 31444334 DOI: 10.1038/S41467-019-11729-1  0.815
2019 Ni Y, Schmidt KR, Werner BA, Koenig JK, Guldner IH, Schnepp PM, Tan X, Jiang L, Host M, Sun L, Howe EN, Wu J, Littlepage LE, Nakshatri H, Zhang S. Death effector domain-containing protein induces vulnerability to cell cycle inhibition in triple-negative breast cancer. Nature Communications. 10: 2860. PMID 31253784 DOI: 10.1038/S41467-019-10743-7  0.787
2019 Rodriguez K, Howe E, Bacher E, Burnette M, Meloche J, Meisel J, Schnepp P, Tan X, Chang M, Zartman J, Zhang S, Ashfeld BL. Combined Scaffold Evaluation and Systems-level Transcriptome-Based Analysis for Accelerated Lead Optimization Reveals Ribosomal Targeting Spirooxindole Cyclopropanes. Chemmedchem. PMID 31140738 DOI: 10.1002/Cmdc.201900266  0.784
2019 Zhang Y, Nichols EL, Zellmer AM, Guldner IH, Kankel C, Zhang S, Howard SS, Smith CJ. Generating intravital super-resolution movies with conventional microscopy reveals actin dynamics that construct pioneer axons. Development (Cambridge, England). PMID 30760484 DOI: 10.1242/Dev.171512  0.713
2019 Rodriguez KX, Howe EN, Bacher EP, Burnette M, Meloche JL, Meisel J, Schnepp P, Tan X, Chang M, Zartman J, Zhang S, Ashfeld BL. Front Cover: Combined Scaffold Evaluation and Systems‐Level Transcriptome‐Based Analysis for Accelerated Lead Optimization Reveals Ribosomal Targeting Spirooxindole Cyclopropanes (ChemMedChem 18/2019) Chemmedchem. 14: 1618-1618. DOI: 10.1002/Cmdc.201900502  0.746
2018 Yue X, Nguyen TD, Zellmer V, Zhang S, Zorlutuna P. Stromal cell-laden 3D hydrogel microwell arrays as tumor microenvironment model for studying stiffness dependent stromal cell-cancer interactions. Biomaterials. 170: 37-48. PMID 29653286 DOI: 10.1016/J.Biomaterials.2018.04.001  0.834
2018 O'Tighearnaigh TK, Howe EN, Schnepp PM, Zhang S. Abstract LB-359: Role of metabolic adaptation to the brain microenvironment in facilitating brain metastasis progression Tumor Biology. DOI: 10.1158/1538-7445.Am2018-Lb-359  0.79
2018 Lager TW, Conner HC, Guldner IH, Wu MZ, Hishida Y, Hishida T, Ruiz S, Yamasaki AE, Belmonte JCI, Gray PC, Kelber JA, Zhang S, Panopoulos AD. Abstract 1990: Aberrant cell surface expression of GRP78 in breast cancer cells marks a stem-like population that has increased metastatic potential in vivo Cancer Research. 78: 1990-1990. DOI: 10.1158/1538-7445.Am2018-1990  0.804
2017 Barron M, Zhang S, Li J. A sparse differential clustering algorithm for tracing cell type changes via single-cell RNA-sequencing data. Nucleic Acids Research. PMID 29140455 DOI: 10.1093/Nar/Gkx1113  0.315
2017 Tang Z, Ding S, Huang H, Luo P, Qing B, Qing B, Zhang S, Tang R. HDAC1 triggers the proliferation and migration of breast cancer cells via upregulation of interleukin-8. Biological Chemistry. PMID 28779562 DOI: 10.1515/hsz-2017-0155  0.321
2017 Schnepp PM, Lee DD, Guldner IH, O'Tighearnaigh TK, Howe EN, Palakurthi B, Eckert KE, Toni TA, Ashfeld BL, Zhang S. GAD1 Upregulation Programs Aggressive Features of Cancer Cell Metabolism in the Brain Metastatic Microenvironment. Cancer Research. PMID 28400476 DOI: 10.1158/0008-5472.Can-16-2289  0.789
2017 Casey J, Yue X, Nguyen D, Acun A, Zellmer V, Zhang S, Zorlutuna P. 3D Hydrogel-Based Microwell Arrays As A Tumor Microenvironment Model To Study Breast Cancer Growth. Biomedical Materials (Bristol, England). PMID 28143999 DOI: 10.1088/1748-605X/Aa5D5C  0.834
2017 Zellmer VR, Schnepp PM, Fracci SL, Tan X, Howe EN, Zhang S. Tumor-induced Stromal STAT1 Accelerates Breast Cancer via Deregulating Tissue Homeostasis. Molecular Cancer Research : McR. PMID 28108623 DOI: 10.1158/1541-7786.Mcr-16-0312  0.809
2017 Schmidt KR, Ni Y, Zhang S. Abstract LB-321: Cytoplasmic DEDD promotes G1- to S-phase cell cycle transition Cancer Research. 77. DOI: 10.1158/1538-7445.Am2017-Lb-321  0.633
2017 Guldner IH, Yang L, Liu F, Chen DZ, Zhang S. Abstract 886: An integrative platform for three-dimensional quantitative analysis of spatially heterogeneous metastasis landscapes Cancer Research. 77: 886-886. DOI: 10.1158/1538-7445.Am2017-886  0.718
2017 Schnepp PM, Lee DD, Guldner IH, O'Tighearnaigh T, Palakurthi B, Eckert KE, Toni TA, Ashfeld BL, Zhang S. Abstract 4934: Brain metastatic microenvironment reshapes cancer cell metabolism through epigenetic up-regulation of glutamate decarboxylase 1 Cancer Research. 77: 4934-4934. DOI: 10.1158/1538-7445.Am2017-4934  0.805
2017 Barrios WVA, Lu H, Cowdrick KR, Galarneau M, Jiang L, Lake M, Yang L, Chen D, Hoelzle D, Peng Z, Zhang S. Abstract 3925: Integrative platform for the reconstruction and modeling of mechanically arrested single cells in the brain vasculature under spatial constraint and shear stress Cancer Research. 77: 3925-3925. DOI: 10.1158/1538-7445.Am2017-3925  0.32
2017 Zellmer VR, Schnepp PM, Fracci SL, Tan X, Howe EN, Zhang S. Abstract 2983: Tumor induced stromal STAT1 deregulates mammary tissue homeostasis and accelerates breast cancer Cancer Research. 77: 2983-2983. DOI: 10.1158/1538-7445.Am2017-2983  0.793
2016 Guldner IH, Yang L, Cowdrick KR, Wang Q, Alvarez Barrios WV, Zellmer VR, Zhang Y, Host M, Liu F, Chen DZ, Zhang S. An Integrative Platform for Three-dimensional Quantitative Analysis of Spatially Heterogeneous Metastasis Landscapes. Scientific Reports. 6: 24201. PMID 27068335 DOI: 10.1038/Srep24201  0.773
2016 Mason JA, Davison-Versagli CA, Leliaert AK, Pape DJ, McCallister C, Zuo J, Durbin SM, Buchheit CL, Zhang S, Schafer ZT. Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells. Cell Death and Differentiation. PMID 26915296 DOI: 10.1038/Cdd.2016.15  0.371
2016 Narciso C, Cowdrick KR, Zellmer V, Brito-Robinson T, Brodskiy P, Hoelzle DJ, Zhang S, Zartman JJ. On-chip three-dimensional tissue histology for microbiopsies Biomicrofluidics. 10. DOI: 10.1063/1.4941708  0.76
2015 Zhang L, Zhang S, Yao J, Lowery FJ, Zhang Q, Huang WC, Li P, Li M, Wang X, Zhang C, Wang H, Ellis K, Cheerathodi M, McCarty JH, Palmieri D, et al. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. PMID 26479035 DOI: 10.1038/Nature15376  0.647
2015 Ni Y, Zhang S. Erbb4 Signaling: an overlooked backup system? Cell Cycle (Georgetown, Tex.). 14: 1623. PMID 25945734 DOI: 10.1080/15384101.2015.1032653  0.704
2015 Rayavarapu RR, Heiden B, Pagani N, Shaw MM, Shuff S, Zhang S, Schafer ZT. The role of multicellular aggregation in the survival of ErbB2-positive breast cancer cells during extracellular matrix detachment. The Journal of Biological Chemistry. 290: 8722-33. PMID 25681438 DOI: 10.1074/Jbc.M114.612754  0.485
2015 Guldner IH, Zhang S. A journey to uncharted territory: new technical frontiers in studying tumor-stromal cell interactions. Integrative Biology : Quantitative Biosciences From Nano to Macro. 7: 153-61. PMID 25500646 DOI: 10.1039/C4Ib00192C  0.771
2014 Zellmer VR, Zhang S. Evolving concepts of tumor heterogeneity. Cell & Bioscience. 4: 69. PMID 25937891 DOI: 10.1186/2045-3701-4-69  0.804
2014 Rehman SK, Li SH, Wyszomierski SL, Wang Q, Li P, Sahin O, Xiao Y, Zhang S, Xiong Y, Yang J, Wang H, Guo H, Zhang JD, Medina D, Muller WJ, et al. 14-3-3ζ orchestrates mammary tumor onset and progression via miR-221-mediated cell proliferation. Cancer Research. 74: 363-73. PMID 24197133 DOI: 10.1158/0008-5472.Can-13-2016  0.728
2013 Zhang S, Huang WC, Zhang L, Zhang C, Lowery FJ, Ding Z, Guo H, Wang H, Huang S, Sahin AA, Aldape KD, Steeg PS, Yu D. SRC family kinases as novel therapeutic targets to treat breast cancer brain metastases. Cancer Research. 73: 5764-74. PMID 23913825 DOI: 10.1158/0008-5472.Can-12-1803  0.68
2013 Ke S, Wang W, Qiu X, Zhang F, Yustein JT, Cameron AG, Zhang S, Yu D, Zou C, Gao X, Lin J, Yallampalli S, Li M. Multiple target-specific molecular agents for detection and image analysis of breast cancer characteristics in mice. Current Molecular Medicine. 13: 446-58. PMID 23331017 DOI: 10.2174/1566524011313030014  0.617
2012 Zhang S, Yu D. Targeting Src family kinases in anti-cancer therapies: turning promise into triumph. Trends in Pharmacological Sciences. 33: 122-8. PMID 22153719 DOI: 10.1016/J.Tips.2011.11.002  0.621
2012 Zhang S, Zhang C, Huang W, Lowery FJ, Huang S, Aldape KD, Steeg PS, Yu D. Abstract 2974: Combating breast cancer brain metastasis by targeting Src family kinases Cancer Research. 72: 2974-2974. DOI: 10.1158/1538-7445.Am2012-2974  0.629
2011 Morrow PK, Wulf GM, Ensor J, Booser DJ, Moore JA, Flores PR, Xiong Y, Zhang S, Krop IE, Winer EP, Kindelberger DW, Coviello J, Sahin AA, Nuñez R, Hortobagyi GN, et al. Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 29: 3126-32. PMID 21730275 DOI: 10.1200/Jco.2010.32.2321  0.623
2011 Zhang S, Huang WC, Li P, Guo H, Poh SB, Brady SW, Xiong Y, Tseng LM, Li SH, Ding Z, Sahin AA, Esteva FJ, Hortobagyi GN, Yu D. Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nature Medicine. 17: 461-9. PMID 21399647 DOI: 10.1038/Nm.2309  0.596
2011 Zhang S, Huang W, Li P, Guo H, Poh S, Brady S, Xiong Y, Tseng L, Li S, Ding Z, Sahin A, Esteva F, Hortobagyi G, Yu D. Abstract LB-379: Combating trastuzumab resistance by targeting Src, a common node downstream of multiple resistance pathways Cancer Research. 71. DOI: 10.1158/1538-7445.Am2011-Lb-379  0.519
2011 Li S, Wyszomierski SL, Li P, Wang Q, Rehman SK, Xiong Y, Yang J, Guo H, Zhang S, Fang D, Medina D, Muller WJ, Yu D. Abstract 2386: Overexpression of 14-3-3ζ in mouse mammary gland promotes mammary tumor development and progression by enhancing multiple tumor-associated properties Cancer Research. 71: 2386-2386. DOI: 10.1158/1538-7445.Am2011-2386  0.628
2011 Jain S, Shah M, Li P, Wang Q, Zhang S. Abstract 1857: Src: A novel target for chemoprevention of early stage ER- breast cancer Cancer Research. 71: 1857-1857. DOI: 10.1158/1538-7445.Am2011-1857  0.447
2010 Esteva FJ, Guo H, Zhang S, Santa-Maria C, Stone S, Lanchbury JS, Sahin AA, Hortobagyi GN, Yu D. PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer. The American Journal of Pathology. 177: 1647-56. PMID 20813970 DOI: 10.2353/Ajpath.2010.090885  0.594
2010 Zhang S, Yu D. PI(3)king apart PTEN's role in cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 16: 4325-30. PMID 20622047 DOI: 10.1158/1078-0432.Ccr-09-2990  0.636
2010 Wang W, Qiu X, Carmeron AG, Zhang S, Yu D, Mawad ME, Shi K. Abstract 5233: Imaging breast cancer xenograft using multienergy modality and target-specific molecular agents Cancer Research. 70: 5233-5233. DOI: 10.1158/1538-7445.Am10-5233  0.593
2006 Zhang S, Li Z, Wu X, Huang Q, Shen HM, Ong CN. Methyl-3-indolylacetate inhibits cancer cell invasion by targeting the MEK1/2-ERK1/2 signaling pathway. Molecular Cancer Therapeutics. 5: 3285-93. PMID 17172432 DOI: 10.1158/1535-7163.Mct-06-0240  0.321
2005 Zhang S, Shen HM, Ong CN. Down-regulation of c-FLIP contributes to the sensitization effect of 3,3'-diindolylmethane on TRAIL-induced apoptosis in cancer cells. Molecular Cancer Therapeutics. 4: 1972-81. PMID 16373712 DOI: 10.1158/1535-7163.Mct-05-0249  0.405
2005 Zhang S, Won YK, Ong CN, Shen HM. Anti-cancer potential of sesquiterpene lactones: bioactivity and molecular mechanisms. Current Medicinal Chemistry. Anti-Cancer Agents. 5: 239-49. PMID 15992352 DOI: 10.2174/1568011053765976  0.378
2004 Zhang S, Lin ZN, Yang CF, Shi X, Ong CN, Shen HM. Suppressed NF-kappaB and sustained JNK activation contribute to the sensitization effect of parthenolide to TNF-alpha-induced apoptosis in human cancer cells. Carcinogenesis. 25: 2191-9. PMID 15256485 DOI: 10.1093/Carcin/Bgh234  0.301
2004 Zhang S, Ong CN, Shen HM. Critical roles of intracellular thiols and calcium in parthenolide-induced apoptosis in human colorectal cancer cells. Cancer Letters. 208: 143-53. PMID 15142672 DOI: 10.1016/J.Canlet.2003.11.028  0.333
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