Andrew Aguirre, M.D., Ph.D.
Affiliations: | Dana Farber Cancer Institute, Boston, MA, United States |
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| Kwon JJ, Dilly J, Liu S, et al. (2024) Comprehensive structure-function analysis reveals gain- and loss-of-function mechanisms impacting oncogenic KRAS activity. Biorxiv : the Preprint Server For Biology |
| Singh H, Xiu J, Kapner KS, et al. (2024) Clinical and genomic features of classical and basal transcriptional subtypes in pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research |
| Aguirre AJ, Stanger BZ, Maitra A. (2024) Hope on the Horizon: A Revolution in KRAS Inhibition Is Creating a New Treatment Paradigm for Patients with Pancreatic Cancer. Cancer Research. 84: 2950-2953 |
| Holderfield M, Lee BJ, Jiang J, et al. (2024) Concurrent inhibition of oncogenic and wild-type RAS-GTP for cancer therapy. Nature |
| Tong X, Patel AS, Kim E, et al. (2024) Adeno-to-squamous transition drives resistance to KRAS inhibition in LKB1 mutant lung cancer. Cancer Cell |
| Singh H, Sahgal P, Kapner K, et al. (2024) RAS/RAF co-mutation and ERBB2 copy number modulates HER2 heterogeneity and responsiveness to HER2-directed therapy in colorectal cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research |
| Schaefer A, Hodge RG, Zhang H, et al. (2023) RHOA drives the development of diffuse gastric cancer through IGF1R-PAK1-YAP1 signaling. Science Signaling. 16: eadg5289 |
| Singh H, Keller RB, Kapner KS, et al. (2023) Oncogenic drivers and therapeutic vulnerabilities in KRAS wild-type pancreatic cancer. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research |
| Qiang L, Hoffman MT, Ali LR, et al. (2023) TGFβ blockade in pancreatic cancer enhances sensitivity to combination chemotherapy. Gastroenterology |
| de Matos Simoes R, Shirasaki R, Downey-Kopyscinski SL, et al. (2023) Genome-scale functional genomics identify genes preferentially essential for multiple myeloma cells compared to other neoplasias. Nature Cancer. 4: 754-773 |