Andrew E. Jaffe, Ph.D. - Publications

Affiliations: 
2012 Johns Hopkins University, Baltimore, MD 
Area:
Epidemiology, Bioinformatics Biology

115 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Rodriguez LA, Tran MN, Garcia-Flores R, Oh S, Phillips RA, Pattie EA, Divecha HR, Kim SH, Shin JH, Lee YK, Montoya C, Jaffe AE, Collado-Torres L, Page SC, Martinowich K. TrkB-dependent regulation of molecular signaling across septal cell types. Translational Psychiatry. 14: 52. PMID 38263132 DOI: 10.1038/s41398-024-02758-6  0.306
2023 Rodriguez LA, Tran MN, Garcia-Flores R, Pattie EA, Divecha HR, Kim SH, Shin JH, Lee YK, Montoya C, Jaffe AE, Collado-Torres L, Page SC, Martinowich K. TrkB-dependent regulation of molecular signaling across septal cell types. Biorxiv : the Preprint Server For Biology. PMID 37425939 DOI: 10.1101/2023.06.29.547069  0.306
2022 Shu C, Jaffe AE, Sabunciyan S, Ji H, Astemborski J, Sun J, Bakulski KM, Sosnowski DW, Mehta SH, Kirk GD, Maher BS. Epigenome-wide association analyses of active injection drug use. Drug and Alcohol Dependence. 235: 109431. PMID 35395503 DOI: 10.1016/j.drugalcdep.2022.109431  0.538
2022 Zandi PP, Jaffe AE, Goes FS, Burke EE, Collado-Torres L, Huuki-Myers L, Seyedian A, Lin Y, Seifuddin F, Pirooznia M, Ross CA, Kleinman JE, Weinberger DR, Hyde TM. Amygdala and anterior cingulate transcriptomes from individuals with bipolar disorder reveal downregulated neuroimmune and synaptic pathways. Nature Neuroscience. 25: 381-389. PMID 35260864 DOI: 10.1038/s41593-022-01024-6  0.305
2022 Perzel Mandell KA, Eagles NJ, Deep-Soboslay A, Tao R, Han S, Wilton R, Szalay AS, Hyde TM, Kleinman JE, Jaffe AE, Weinberger DR. Molecular phenotypes associated with antipsychotic drugs in the human caudate nucleus. Molecular Psychiatry. PMID 35236959 DOI: 10.1038/s41380-022-01453-6  0.303
2022 Ramnauth AD, Maynard KR, Kardian AS, Phan BN, Tippani M, Rajpurohit S, Hobbs JW, Page SC, Jaffe AE, Martinowich K. Induction of Bdnf from promoter I following electroconvulsive seizures contributes to structural plasticity in neurons of the piriform cortex. Brain Stimulation. PMID 35183789 DOI: 10.1016/j.brs.2022.02.003  0.71
2021 Perzel Mandell KA, Eagles NJ, Wilton R, Price AJ, Semick SA, Collado-Torres L, Ulrich WS, Tao R, Han S, Szalay AS, Hyde TM, Kleinman JE, Weinberger DR, Jaffe AE. Genome-wide sequencing-based identification of methylation quantitative trait loci and their role in schizophrenia risk. Nature Communications. 12: 5251. PMID 34475392 DOI: 10.1038/s41467-021-25517-3  0.303
2021 Eagles NJ, Burke EE, Leonard J, Barry BK, Stolz JM, Huuki L, Phan BN, Serrato VL, Gutiérrez-Millán E, Aguilar-Ordoñez I, Jaffe AE, Collado-Torres L. Correction to: SPEAQeasy: a scalable pipeline for expression analysis and quantification for R/bioconductor‑powered RNA‑seq analyses. Bmc Bioinformatics. 22: 381. PMID 34294043 DOI: 10.1186/s12859-021-04283-5  0.69
2021 Eagles NJ, Burke EE, Leonard J, Barry BK, Stolz JM, Huuki L, Phan BN, Serrato VL, Gutiérrez-Millán E, Aguilar-Ordoñez I, Jaffe AE, Collado-Torres L. SPEAQeasy: a scalable pipeline for expression analysis and quantification for R/bioconductor-powered RNA-seq analyses. Bmc Bioinformatics. 22: 224. PMID 33932985 DOI: 10.1186/s12859-021-04142-3  0.712
2021 Takahashi Y, Maynard KR, Tippani M, Jaffe AE, Martinowich K, Kleinman JE, Weinberger DR, Hyde TM. Single molecule in situ hybridization reveals distinct localizations of schizophrenia risk-related transcripts SNX19 and AS3MT in human brain. Molecular Psychiatry. PMID 33649454 DOI: 10.1038/s41380-021-01046-9  0.328
2021 Maynard KR, Collado-Torres L, Weber LM, Uytingco C, Barry BK, Williams SR, Catallini JL, Tran MN, Besich Z, Tippani M, Chew J, Yin Y, Kleinman JE, Hyde TM, Rao N, ... ... Jaffe AE, et al. Transcriptome-scale spatial gene expression in the human dorsolateral prefrontal cortex. Nature Neuroscience. PMID 33558695 DOI: 10.7490/F1000Research.1118079.1  0.387
2020 Shu C, Jaffe AE, Sabunciyan S, Ji H, Astemborski J, Sun J, Bakulski KM, Mehta SH, Kirk GD, Maher BS. Epigenome-wide association scan identifies methylation sites associated with HIV infection. Epigenomics. PMID 33232214 DOI: 10.2217/epi-2020-0123  0.541
2020 Zhang D, Guelfi S, Garcia-Ruiz S, Costa B, Reynolds RH, D'Sa K, Liu W, Courtin T, Peterson A, Jaffe AE, Hardy J, Botía JA, Collado-Torres L, Ryten M. Incomplete annotation has a disproportionate impact on our understanding of Mendelian and complex neurogenetic disorders. Science Advances. 6. PMID 32917675 DOI: 10.1126/Sciadv.Aay8299  0.4
2020 Haghani A, Johnson RG, Woodward NC, Feinberg JI, Lewis K, Ladd-Acosta C, Safi N, Jaffe AE, Sioutas C, Allayee H, Campbell DB, Volk HE, Finch CE, Morgan TE. Adult mouse hippocampal transcriptome changes associated with long-term behavioral and metabolic effects of gestational air pollution toxicity. Translational Psychiatry. 10: 218. PMID 32636363 DOI: 10.1038/S41398-020-00907-1  0.329
2020 Lin CW, Chang LC, Ma T, Oh H, French B, Puralewski R, Mathews F, Fang Y, Lewis DA, Kennedy JL, Mueller D, Marshe VS, Jaffe A, Chen Q, Ursini G, et al. Older molecular brain age in severe mental illness. Molecular Psychiatry. PMID 32632206 DOI: 10.1038/S41380-020-0834-1  0.362
2020 Perzel Mandell KA, Price AJ, Wilton R, Collado-Torres L, Tao R, Eagles NJ, Szalay AS, Hyde TM, Weinberger DR, Kleinman JE, Jaffe AE. Characterizing the dynamic and functional DNA methylation landscape in the developing human cortex. Epigenetics. PMID 32602773 DOI: 10.1080/15592294.2020.1786304  0.416
2020 Tao R, Li C, Jaffe AE, Shin JH, Deep-Soboslay A, Yamin R, Weinberger DR, Hyde TM, Kleinman JE. Cannabinoid receptor CNR1 expression and DNA methylation in human prefrontal cortex, hippocampus and caudate in brain development and schizophrenia. Translational Psychiatry. 10: 158. PMID 32433545 DOI: 10.1038/S41398-020-0832-8  0.417
2020 Price AJ, Jaffe AE, Weinberger DR. Cortical cellular diversity and development in schizophrenia. Molecular Psychiatry. PMID 32404946 DOI: 10.1038/S41380-020-0775-8  0.371
2020 Maynard KR, Tippani M, Takahashi Y, Phan BN, Hyde TM, Jaffe AE, Martinowich K. dotdotdot: an automated approach to quantify multiplex single molecule fluorescent in situ hybridization (smFISH) images in complex tissues. Nucleic Acids Research. PMID 32383753 DOI: 10.1093/Nar/Gkaa312  0.735
2020 Jaffe AE, Hoeppner DJ, Saito T, Blanpain L, Ukaigwe J, Burke EE, Collado-Torres L, Tao R, Tajinda K, Maynard KR, Tran MN, Martinowich K, Deep-Soboslay A, Shin JH, Kleinman JE, et al. Profiling gene expression in the human dentate gyrus granule cell layer reveals insights into schizophrenia and its genetic risk. Nature Neuroscience. PMID 32203495 DOI: 10.1038/S41593-020-0604-Z  0.393
2020 Imada EL, Sanchez DF, Collado-Torres L, Wilks C, Matam T, Dinalankara W, Stupnikov A, Pereira Lobo FP, Yip CW, Yasuzawa K, Kondo N, Itoh M, Suzuki H, Kasukawa T, Hon CC, ... ... Jaffe AE, et al. Recounting the FANTOM CAGEAssociated Transcriptome. Genome Research. PMID 32079618 DOI: 10.1101/Gr.254656.119  0.382
2020 Phan BN, Bohlen JF, Davis BA, Ye Z, Chen HY, Mayfield B, Sripathy SR, Cerceo Page S, Campbell MN, Smith HL, Gallop D, Kim H, Thaxton CL, Simon JM, Burke EE, ... ... Jaffe AE, et al. A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder. Nature Neuroscience. PMID 32015540 DOI: 10.1038/S41593-019-0578-X  0.734
2020 Burke EE, Chenoweth JG, Shin JH, Collado-Torres L, Kim SK, Micali N, Wang Y, Colantuoni C, Straub RE, Hoeppner DJ, Chen HY, Sellers A, Shibbani K, Hamersky GR, Diaz Bustamante M, ... ... Jaffe AE, et al. Dissecting transcriptomic signatures of neuronal differentiation and maturation using iPSCs. Nature Communications. 11: 462. PMID 31974374 DOI: 10.1038/S41467-019-14266-Z  0.733
2020 Maynard KR, Kardian A, Hill JL, Mai Y, Barry B, Hallock HL, Jaffe AE, Martinowich K. TrkB signaling influences gene expression in cortistatin-expressing interneurons. Eneuro. PMID 31941661 DOI: 10.1523/ENEURO.0310-19.2019  0.301
2019 Price AJ, Hwang T, Burke EE, Rajpurohit A, Shin JH, Hyde TM, Kleinman JE, Jaffe AE, Weinberger DR. Characterizing the nuclear and cytoplasmic transcriptomes in developing and mature human cortex uncovers new insight into psychiatric disease gene regulation. Genome Research. PMID 31852722 DOI: 10.1101/Gr.250217.119  0.404
2019 Ren M, Hu Z, Chen Q, Jaffe A, Li Y, Sadashivaiah V, Zhu S, Rajpurohit N, Heon Shin J, Xia W, Jia Y, Wu J, Lang Qin S, Li X, Zhu J, et al. KCNH2-3.1 mediates aberrant complement activation and impaired hippocampal-medial prefrontal circuitry associated with working memory deficits. Molecular Psychiatry. PMID 31570775 DOI: 10.1038/S41380-019-0530-1  0.373
2019 Price AJ, Collado-Torres L, Ivanov NA, Xia W, Burke EE, Shin JH, Tao R, Ma L, Jia Y, Hyde TM, Kleinman JE, Weinberger DR, Jaffe AE. Divergent neuronal DNA methylation patterns across human cortical development reveal critical periods and a unique role of CpH methylation. Genome Biology. 20: 196. PMID 31554518 DOI: 10.1186/S13059-019-1805-1  0.379
2019 Gådin JR, Buil A, Colantuoni C, Jaffe AE, Nielsen J, Shin JH, Hyde TM, Kleinman JE, Plath N, Eriksson P, Brunak S, Didriksen M, Weinberger DR, Folkersen L. Comparison of quantitative trait loci methods: Total expression and allelic imbalance method in brain RNA-seq. Plos One. 14: e0217765. PMID 31206532 DOI: 10.1371/Journal.Pone.0217765  0.394
2019 Collado-Torres L, Burke EE, Peterson A, Shin J, Straub RE, Rajpurohit A, Semick SA, Ulrich WS, Price AJ, Valencia C, Tao R, Deep-Soboslay A, Hyde TM, Kleinman JE, ... ... Jaffe AE, et al. Regional Heterogeneity in Gene Expression, Regulation, and Coherence in the Frontal Cortex and Hippocampus across Development and Schizophrenia. Neuron. PMID 31174959 DOI: 10.1016/J.Neuron.2019.05.013  0.375
2019 Pergola G, Di Carlo P, Jaffe AE, Papalino M, Chen Q, Hyde TM, Kleinman JE, Shin JH, Rampino A, Blasi G, Weinberger DR, Bertolino A. Prefrontal Coexpression of Schizophrenia Risk Genes Is Associated With Treatment Response in Patients. Biological Psychiatry. PMID 31126695 DOI: 10.1016/J.Biopsych.2019.03.981  0.332
2019 Parsana P, Ruberman C, Jaffe AE, Schatz MC, Battle A, Leek JT. Addressing confounding artifacts in reconstruction of gene co-expression networks. Genome Biology. 20: 94. PMID 31097038 DOI: 10.1186/S13059-019-1700-9  0.323
2019 Semick SA, Bharadwaj RA, Collado-Torres L, Tao R, Shin JH, Deep-Soboslay A, Weiss JR, Weinberger DR, Hyde TM, Kleinman JE, Jaffe AE, Mattay VS. Integrated DNA methylation and gene expression profiling across multiple brain regions implicate novel genes in Alzheimer's disease. Acta Neuropathologica. PMID 30712078 DOI: 10.1007/S00401-019-01966-5  0.389
2019 Ma L, Semick SA, Chen Q, Li C, Tao R, Price AJ, Shin JH, Jia Y, Brandon NJ, Cross AJ, Hyde TM, Kleinman JE, Jaffe AE, Weinberger DR, et al. Schizophrenia risk variants influence multiple classes of transcripts of sorting nexin 19 (SNX19). Molecular Psychiatry. PMID 30635639 DOI: 10.1038/S41380-018-0293-0  0.419
2019 Carlo PD, Pergola G, Jaffe AE, Papalino M, Chen Q, Hyde TM, Kleinman JE, Shin JH, Rampino A, Blasi G, Weinberger DR, Bertolino A. F104. GENE CO-EXPRESSION NETWORKS REVEAL PATHWAYS OF CONVERGENCE OF SCHIZOPHRENIA RISK GENES AND OF RESPONSE TO TREATMENT Schizophrenia Bulletin. 45: S293-S293. DOI: 10.1093/Schbul/Sbz018.516  0.321
2019 Di Carlo P, Deyssenroth M, Jaffe AE, Chen Q, Punzi G, Bertolino A, Marsit CJ, Chen J, Hao K, Weinberger DR, Ursini G. Genomic risk for schizophrenia converges into isoform-level coexpression network of the placental transcriptome Placenta. 83: e11-e12. DOI: 10.1016/J.Placenta.2019.06.043  0.307
2019 Shu C, Bakulski K, Benke K, Jaffe A, Wang S, Sabunciyan S, Mehta S, Kirk G, Maher B. DNA METHYLATION MARKERS ASSOCIATED WITH INJECTION DRUG USE STATUS AND HIV INFECTION AMONG CHRONIC INJECTION DRUG USERS IN THE ALIVE STUDY European Neuropsychopharmacology. 29: S1014-S1015. DOI: 10.1016/J.Euroneuro.2017.08.416  0.706
2019 Pergola G, Carlo PD, Jaffe A, Papalino M, Blasi G, Weinberger D, Bertolino A. Gene Co-Expression Reveals Pathways Of Convergence Of Schizophrenia Risk Genes European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2017.08.413  0.408
2019 Radulescu E, Straub RE, Jaffe AE, Heon Shin J, Chen Q, Weinberger DR. DIFFERENTIAL DISTRIBUTION OF SCHIZOPHRENIA RISK GENES WITHIN GENE CO-EXPRESSION NETWORKS CONSTRUCTED FROM RNA-SEQ DATA (POSTMORTEM DLPFC) OF AFFECTED AND UNAFFECTED INDIVIDUALS European Neuropsychopharmacology. 29: S946-S947. DOI: 10.1016/J.Euroneuro.2017.08.295  0.403
2019 Ma L, Semick S, Chen Q, Tao R, Price A, Shin JH, Hyde T, Kleinman J, Brandon N, Cross A, Jaffe A, Weinberger D, Straub R. Overexpression Of Multiple Transcripts Of Snx19 (Sorting Nexin 19) In Multiple Brain Regions May Contribute To Schizophrenia Risk European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2017.08.036  0.407
2019 Morris D, Mill J, Jaffe A. Functional Genomic Regulation In The Brain: (Epi)Genetic Variation, Neurodevelopment and Psychiatric Disease European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2017.06.135  0.45
2019 Bierut L, Hancock D, Jaffe A, Johnson E. Putting Genes In Context: Applying Integrative 'Omics To Alcohol Use Disorder European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2017.06.076  0.329
2019 Jaffe A. Developmental and Genetic Regulation of The Human Cortex Transcriptome In Schizophrenia European Neuropsychopharmacology. 29. DOI: 10.1016/J.Euroneuro.2017.06.075  0.42
2018 Punzi G, Ursini G, Viscanti G, Radulescu E, Shin JH, Quarto T, Catanesi R, Blasi G, Jaffe AE, Deep-Soboslay A, Hyde TM, Kleinman JE, Bertolino A, Weinberger DR. Association of a Noncoding RNA Postmortem With Suicide by Violent Means and In Vivo With Aggressive Phenotypes. Biological Psychiatry. PMID 30600091 DOI: 10.1016/J.Biopsych.2018.11.002  0.325
2018 Wang D, Liu S, Warrell J, Won H, Shi X, Navarro FCP, Clarke D, Gu M, Emani P, Yang YT, Xu M, Gandal MJ, Lou S, Zhang J, Park JJ, ... ... Jaffe AE, et al. Comprehensive functional genomic resource and integrative model for the human brain. Science (New York, N.Y.). 362. PMID 30545857 DOI: 10.1126/Science.Aat8464  0.411
2018 Gandal MJ, Zhang P, Hadjimichael E, Walker RL, Chen C, Liu S, Won H, van Bakel H, Varghese M, Wang Y, Shieh AW, Haney J, Parhami S, Belmont J, Kim M, ... ... Jaffe AE, et al. Transcriptome-wide isoform-level dysregulation in ASD, schizophrenia, and bipolar disorder. Science (New York, N.Y.). 362. PMID 30545856 DOI: 10.1126/Science.Aat8127  0.415
2018 Kuri-Magaña H, Collado-Torres L, Jaffe AE, Valdovinos-Torres H, Ovilla-Muñoz M, Téllez-Sosa J, Bonifaz LC, Martínez-Barnetche J. Non-coding Class Switch Recombination-Related Transcription in Human Normal and Pathological Immune Responses. Frontiers in Immunology. 9: 2679. PMID 30519242 DOI: 10.3389/Fimmu.2018.02679  0.356
2018 Radulescu E, Jaffe AE, Straub RE, Chen Q, Shin JH, Hyde TM, Kleinman JE, Weinberger DR. Identification and prioritization of gene sets associated with schizophrenia risk by co-expression network analysis in human brain. Molecular Psychiatry. PMID 30478419 DOI: 10.1038/S41380-018-0304-1  0.409
2018 Maynard KR, Hobbs JW, Phan BN, Gupta A, Rajpurohit S, Williams C, Rajpurohit N, Shin JH, Jaffe AE, Martinowich K. BDNF-TrkB signaling in oxytocin neurons contributes to maternal behavior. Elife. 7. PMID 30192229 DOI: 10.7554/Elife.33676  0.734
2018 Semick SA, Collado-Torres L, Markunas CA, Shin JH, Deep-Soboslay A, Tao R, Huestis MA, Bierut LJ, Maher BS, Johnson EO, Hyde TM, Weinberger DR, Hancock DB, Kleinman JE, Jaffe AE. Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome. Molecular Psychiatry. PMID 30131587 DOI: 10.1038/S41380-018-0223-1  0.337
2018 Boks MP, Houtepen LC, Xu Z, He Y, Ursini G, Maihofer AX, Rajarajan P, Yu Q, Xu H, Wu Y, Wang S, Shi JP, Hulshoff Pol HE, Strengman E, Rutten BPF, ... Jaffe AE, et al. Genetic vulnerability to DUSP22 promoter hypermethylation is involved in the relation between in utero famine exposure and schizophrenia. Npj Schizophrenia. 4: 16. PMID 30131491 DOI: 10.1038/S41537-018-0058-4  0.383
2018 Jaffe AE, Straub RE, Shin JH, Tao R, Gao Y, Collado-Torres L, Kam-Thong T, Xi HS, Quan J, Chen Q, Colantuoni C, Ulrich WS, Maher BJ, Deep-Soboslay A, et al. Developmental and genetic regulation of the human cortex transcriptome illuminate schizophrenia pathogenesis. Nature Neuroscience. 21: 1117-1125. PMID 30050107 DOI: 10.1038/S41593-018-0197-Y  0.432
2018 Ursini G, Punzi G, Chen Q, Marenco S, Robinson JF, Porcelli A, Hamilton EG, Mitjans M, Maddalena G, Begemann M, Seidel J, Yanamori H, Jaffe AE, Berman KF, Egan MF, et al. Convergence of placenta biology and genetic risk for schizophrenia. Nature Medicine. PMID 29808008 DOI: 10.1038/S41591-018-0021-Y  0.388
2018 Giambartolomei C, Zhenli Liu J, Zhang W, Hauberg M, Shi H, Boocock J, Pickrell J, Jaffe AE, Pasaniuc B, Roussos P. A Bayesian Framework for Multiple Trait Colo-calization from Summary Association Statistics. Bioinformatics (Oxford, England). PMID 29579179 DOI: 10.1093/Bioinformatics/Bty147  0.388
2018 Ellis SE, Collado-Torres L, Jaffe A, Leek JT. Improving the value of public RNA-seq expression data by phenotype prediction. Nucleic Acids Research. PMID 29514223 DOI: 10.1093/Nar/Gky102  0.348
2018 Maynard KR, Hobbs JW, Phan BN, Gupta A, Rajpurohit S, Williams C, Rajpurohit A, Shin JH, Jaffe AE, Martinowich K. Author response: BDNF-TrkB signaling in oxytocin neurons contributes to maternal behavior Elife. DOI: 10.7554/Elife.33676.023  0.708
2018 Luidy-Imada E, Matam T, Collado-Torres L, Dinalankara W, Stupnikov A, Wilks C, Jaffe AE, Langmead B, Leek JT, Favorov A, Marchionni L. Abstract 2297: Differential analysis of gene expression across the human genome using recount2 and FANTOM-CAT Cancer Research. 78: 2297-2297. DOI: 10.1158/1538-7445.Am2018-2297  0.39
2018 Ursini G, Punzi G, Chen Q, Marenco S, Robinson JF, Porcelli A, Hamilton E, Mitjans M, Maddalena G, Begemann M, Seidel J, Yanamori H, Jaffe AE, Berman KF, Egan MF, et al. O4.7. PLACENTAL GENE EXPRESSION, OBSTETRICAL HISTORY AND POLYGENIC RISK FOR SCHIZOPHRENIA Schizophrenia Bulletin. 44: S85-S86. DOI: 10.1093/Schbul/Sby015.213  0.324
2018 Boks M, Houtepen L, Xu Z, He Y, Ursini G, Maihofer A, Rajarajan P, Hulshoff Pol H, Rutten B, Jaffe AE, Kleinmann JE, Baker D, Hol E, Akbarian S, Nievergelt C, et al. O4.1. GENETIC VULNERABILITY TO DUSP22 PROMOTOR HYPERMETHYLATION IS INVOLVED IN THE RELATION BETWEEN IN UTERO FAMINE EXPOSURE AND SCHIZOPHRENIA Schizophrenia Bulletin. 44: S82-S82. DOI: 10.1093/Schbul/Sby015.207  0.404
2018 Hoeppner D, Jaffe A, Ukaigwe J, Blanpain L, Tao R, McKay R, Matsumoto M, Kleinman J, Weinberger D, Hyde T. 262. Human Dg-Seq Reveals Cell-Type-Specific Effectors of Schizophrenia Risk Biological Psychiatry. 83. DOI: 10.1016/J.Biopsych.2018.02.281  0.302
2017 Collado-Torres L, Nellore A, Jaffe AE. recount workflow: Accessing over 70,000 human RNA-seq samples with Bioconductor. F1000research. 6: 1558. PMID 29043067 DOI: 10.12688/F1000Research.12223.1  0.347
2017 Jaffe AE, Tao R, Norris AL, Kealhofer M, Nellore A, Shin JH, Kim D, Jia Y, Hyde TM, Kleinman JE, Straub RE, Leek JT, Weinberger DR. qSVA framework for RNA quality correction in differential expression analysis. Proceedings of the National Academy of Sciences of the United States of America. PMID 28634288 DOI: 10.1073/Pnas.1617384114  0.345
2017 Rutten BPF, Vermetten E, Vinkers CH, Ursini G, Daskalakis NP, Pishva E, de Nijs L, Houtepen LC, Eijssen L, Jaffe AE, Kenis G, Viechtbauer W, van den Hove D, Schraut KG, Lesch KP, et al. Longitudinal analyses of the DNA methylome in deployed military servicemen identify susceptibility loci for post-traumatic stress disorder. Molecular Psychiatry. PMID 28630453 DOI: 10.1038/Mp.2017.120  0.325
2017 Kozlenkov A, Jaffe AE, Timashpolsky A, Apontes P, Rudchenko S, Barbu M, Byne W, Hurd YL, Horvath S, Dracheva S. DNA Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age. Genes. 8. PMID 28556790 DOI: 10.3390/Genes8060152  0.4
2017 Wright C, Shin JH, Rajpurohit A, Deep-Soboslay A, Collado-Torres L, Brandon NJ, Hyde TM, Kleinman JE, Jaffe AE, Cross AJ, Weinberger DR. Altered expression of histamine signaling genes in autism spectrum disorder. Translational Psychiatry. 7: e1126. PMID 28485729 DOI: 10.1038/Tp.2017.87  0.41
2017 Birnbaum R, Jaffe AE, Chen Q, Shin JH, Kleinman JE, Hyde TM, Weinberger DR. Investigating the neuroimmunogenic architecture of schizophrenia. Molecular Psychiatry. PMID 28485405 DOI: 10.1038/Mp.2017.89  0.381
2017 Tao R, Davis KN, Li C, Shin JH, Gao Y, Jaffe AE, Gondré-Lewis MC, Weinberger DR, Kleinman JE, Hyde TM. GAD1 alternative transcripts and DNA methylation in human prefrontal cortex and hippocampus in brain development, schizophrenia. Molecular Psychiatry. PMID 28485403 DOI: 10.1038/Mp.2017.105  0.398
2017 McConnell MJ, Moran JV, Abyzov A, Akbarian S, Bae T, Cortes-Ciriano I, Erwin JA, Fasching L, Flasch DA, Freed D, Ganz J, Jaffe AE, Kwan KY, Kwon M, Lodato MA, et al. Intersection of diverse neuronal genomes and neuropsychiatric disease: The Brain Somatic Mosaicism Network. Science (New York, N.Y.). 356. PMID 28450582 DOI: 10.1126/Science.Aal1641  0.378
2017 Page SC, Hamersky GR, Gallo RA, Rannals MD, Calcaterra NE, Campbell MN, Mayfield B, Briley A, Phan BN, Jaffe AE, Maher BJ. The schizophrenia- and autism-associated gene, transcription factor 4 regulates the columnar distribution of layer 2/3 prefrontal pyramidal neurons in an activity-dependent manner. Molecular Psychiatry. PMID 28289282 DOI: 10.1038/Mp.2017.37  0.751
2017 Ursini G, Punzi G, Chen Q, Marenco S, Jaffe A, Straub R, Berman K, Hashimoto R, Colantuoni C, Blasi G, Annamaria P, Giancarlo M, Joshua R, Emily H, Allessandro B, et al. 115.1 Placental Gene Expression Mediates the Interaction Between Obstetrical History and Genetic Risk for Schizophrenia Schizophrenia Bulletin. 43: S60-S60. DOI: 10.1093/Schbul/Sbx021.158  0.391
2017 Hibar D, Jaffe A, Shin JH, Hyde T, Kleinman J, Weinberger D, Drevets W, Saad Z, Furey M, Kolb H. 555. Gene Expression Differences Associated with Major Psychiatric Disorders in the Human Prefrontal Cortex and Hippocampus Biological Psychiatry. 81. DOI: 10.1016/J.Biopsych.2017.02.1163  0.354
2016 Nellore A, Jaffe AE, Fortin JP, Alquicira-Hernández J, Collado-Torres L, Wang S, Phillips Iii RA, Karbhari N, Hansen KD, Langmead B, Leek JT. Human splicing diversity and the extent of unannotated splice junctions across human RNA-seq samples on the Sequence Read Archive. Genome Biology. 17: 266. PMID 28038678 DOI: 10.1186/S13059-016-1118-6  0.305
2016 Bharadwaj RA, Jaffe AE, Chen Q, Deep-Soboslay A, Goldman AL, Mighdoll MI, Cotoia JA, Brandtjen AC, Shin J, Hyde TM, Mattay VS, Weinberger DR, Kleinman JE. Genetic risk mechanisms of posttraumatic stress disorder in the human brain. Journal of Neuroscience Research. PMID 27775175 DOI: 10.1002/Jnr.23957  0.396
2016 Collado-Torres L, Nellore A, Frazee AC, Wilks C, Love MI, Langmead B, Irizarry RA, Leek JT, Jaffe AE. Flexible expressed region analysis for RNA-seq with derfinder. Nucleic Acids Research. PMID 27694310 DOI: 10.1093/Nar/Gkw852  0.384
2016 Jaffe AE, Kleinman JE. Genetic and epigenetic analysis of schizophrenia in blood-a no-brainer? Genome Medicine. 8: 96. PMID 27655387 DOI: 10.1186/S13073-016-0354-4  0.317
2016 McFadden WC, Jaffe AE, Ye T, Paltán-Ortiz JD, Hyde TM, Kleinman JE. Assessment of genetic risk for distribution of total interstitial white matter neurons in dorsolateral prefrontal cortex: role in schizophrenia. Schizophrenia Research. PMID 27237599 DOI: 10.1016/J.Schres.2016.04.007  0.308
2016 Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth JG, Hoeppner DJ, et al. A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus. Nature Medicine. PMID 27158905 DOI: 10.1038/Nm.4096  0.429
2016 Montano C, Taub MA, Jaffe A, Briem E, Feinberg JI, Trygvadottir R, Idrizi A, Runarsson A, Berndsen B, Gur RC, Moore TM, Perry RT, Fugman D, Sabunciyan S, Yolken RH, et al. Association of DNA Methylation Differences With Schizophrenia in an Epigenome-Wide Association Study. Jama Psychiatry. PMID 27074206 DOI: 10.1001/Jamapsychiatry.2016.0144  0.56
2016 Rannals MD, Hamersky GR, Page SC, Campbell MN, Briley A, Gallo RA, Phan BN, Hyde TM, Kleinman JE, Shin JH, Jaffe AE, Weinberger DR, Maher BJ. Psychiatric Risk Gene Transcription Factor 4 Regulates Intrinsic Excitability of Prefrontal Neurons via Repression of SCN10a and KCNQ1. Neuron. PMID 26971948 DOI: 10.1016/j.neuron.2016.02.021  0.735
2016 Ivanov NA, Tao R, Chenoweth JG, Brandtjen A, Mighdoll MI, Genova JD, McKay RD, Jia Y, Weinberger DR, Kleinman JE, Hyde TM, Jaffe AE. Strong Components of Epigenetic Memory in Cultured Human Fibroblasts Related to Site of Origin and Donor Age. Plos Genetics. 12: e1005819. PMID 26913521 DOI: 10.1371/Journal.Pgen.1005819  0.336
2016 Calcaterra NE, Hoeppner DJ, Wei H, Jaffe AE, Maher BJ, Barrow JC. Schizophrenia-Associated hERG channel Kv11.1-3.1 Exhibits a Unique Trafficking Deficit that is Rescued Through Proteasome Inhibition for High Throughput Screening. Scientific Reports. 6: 19976. PMID 26879421 DOI: 10.1038/Srep19976  0.309
2016 Jaffe AE. Postmortem human brain genomics in neuropsychiatric disorders-how far can we go? Current Opinion in Neurobiology. 36: 107-11. PMID 26685806 DOI: 10.1016/J.Conb.2015.11.002  0.36
2015 Collado-Torres L, Jaffe AE, Leek JT. regionReport: Interactive reports for region-level and feature-level genomic analyses. F1000research. 4: 105. PMID 27429738 DOI: 10.12688/F1000Research.6379.2  0.305
2015 Jaffe AE, Gao Y, Deep-Soboslay A, Tao R, Hyde TM, Weinberger DR, Kleinman JE. Mapping DNA methylation across development, genotype and schizophrenia in the human frontal cortex. Nature Neuroscience. PMID 26619358 DOI: 10.1038/Nn.4181  0.381
2015 Akbarian S, Liu C, Knowles JA, Vaccarino FM, Farnham PJ, Crawford GE, Jaffe AE, Pinto D, Dracheva S, Geschwind DH, Mill J, Nairn AC, Abyzov A, Pochareddy S, Prabhakar S, et al. The PsychENCODE project. Nature Neuroscience. 18: 1707-1712. PMID 26605881 DOI: 10.1038/Nn.4156  0.387
2015 Jaffe AE, Hyde T, Kleinman J, Weinbergern DR, Chenoweth JG, McKay RD, Leek JT, Colantuoni C. Practical impacts of genomic data "cleaning" on biological discovery using surrogate variable analysis. Bmc Bioinformatics. 16: 372. PMID 26545828 DOI: 10.1186/S12859-015-0808-5  0.357
2015 Oliver V, Jaffe AE, Song J, Wang G, Zhang P, Branham KE, Swaroop A, Eberhart CG, Zack DJ, Qian J, Merbs SL. Differential DNA Methylation Identified in the Blood and Retina of AMD Patients. Epigenetics : Official Journal of the Dna Methylation Society. 0. PMID 26067391 DOI: 10.1080/15592294.2015.1060388  0.389
2015 Frazee AC, Jaffe AE, Langmead B, Leek JT. Polyester: simulating RNA-seq datasets with differential transcript expression. Bioinformatics (Oxford, England). PMID 25926345 DOI: 10.1093/Bioinformatics/Btv272  0.329
2015 Bakulski KM, Lee H, Feinberg JI, Wells EM, Brown S, Herbstman JB, Witter FR, Halden RU, Caldwell K, Mortensen ME, Jaffe AE, Moye J, Caulfield LE, Pan Y, Goldman LR, et al. Prenatal mercury concentration is associated with changes in DNA methylation at TCEANC2 in newborns. International Journal of Epidemiology. PMID 25906783 DOI: 10.1093/Ije/Dyv032  0.685
2015 Feinberg JI, Bakulski KM, Jaffe AE, Tryggvadottir R, Brown SC, Goldman LR, Croen LA, Hertz-Picciotto I, Newschaffer CJ, Daniele Fallin M, Feinberg AP. Paternal sperm DNA methylation associated with early signs of autism risk in an autism-enriched cohort. International Journal of Epidemiology. 44: 1199-210. PMID 25878217 DOI: 10.1093/Ije/Dyv028  0.615
2015 Marioni RE, Shah S, McRae AF, Chen BH, Colicino E, Harris SE, Gibson J, Henders AK, Redmond P, Cox SR, Pattie A, Corley J, Murphy L, Martin NG, Montgomery GW, ... ... Jaffe AE, et al. DNA methylation age of blood predicts all-cause mortality in later life. Genome Biology. 16: 25. PMID 25633388 DOI: 10.1186/S13059-015-0584-6  0.522
2015 Birnbaum R, Jaffe AE, Chen Q, Hyde TM, Kleinman JE, Weinberger DR. Investigation of the prenatal expression patterns of 108 schizophrenia-associated genetic loci. Biological Psychiatry. 77: e43-51. PMID 25592863 DOI: 10.1016/J.Biopsych.2014.10.008  0.326
2015 Multhaup ML, Seldin MM, Jaffe AE, Lei X, Kirchner H, Mondal P, Li Y, Rodriguez V, Drong A, Hussain M, Lindgren C, McCarthy M, Näslund E, Zierath JR, Wong GW, et al. Mouse-human experimental epigenetic analysis unmasks dietary targets and genetic liability for diabetic phenotypes. Cell Metabolism. 21: 138-49. PMID 25565211 DOI: 10.1016/J.Cmet.2014.12.014  0.354
2015 Jaffe AE, Shin J, Collado-Torres L, Leek JT, Tao R, Li C, Gao Y, Jia Y, Maher BJ, Hyde TM, Kleinman JE, Weinberger DR. Developmental regulation of human cortex transcription and its clinical relevance at single base resolution. Nature Neuroscience. 18: 154-61. PMID 25501035 DOI: 10.1038/Nn.3898  0.418
2015 Collado-Torres L, Jaffe AE, Leek JT. regionReport: Interactive reports for region-based analyses F1000research. 4: 105. DOI: 10.12688/F1000Research.6379.1  0.308
2015 Schubert CR, O'Donnell P, Quan J, Wendland JR, Xi HS, Winslow AR, Domenici E, Essioux L, Kam-Thong T, Airey DC, Calley JN, Collier DA, Wang H, Eastwood B, Ebert P, ... ... Jaffe AE, et al. BrainSeq: Neurogenomics to Drive Novel Target Discovery for Neuropsychiatric Disorders Neuron. 88: 1078-1083. DOI: 10.1016/J.Neuron.2015.10.047  0.361
2014 Jaffe AE, Deep-Soboslay A, Tao R, Hauptman DT, Kaye WH, Arango V, Weinberger DR, Hyde TM, Kleinman JE. Genetic neuropathology of obsessive psychiatric syndromes. Translational Psychiatry. 4: e432. PMID 25180571 DOI: 10.1038/Tp.2014.68  0.396
2014 Tao R, Cousijn H, Jaffe AE, Burnet PW, Edwards F, Eastwood SL, Shin JH, Lane TA, Walker MA, Maher BJ, Weinberger DR, Harrison PJ, Hyde TM, Kleinman JE. Expression of ZNF804A in human brain and alterations in schizophrenia, bipolar disorder, and major depressive disorder: a novel transcript fetally regulated by the psychosis risk variant rs1344706. Jama Psychiatry. 71: 1112-20. PMID 25162540 DOI: 10.1001/Jamapsychiatry.2014.1079  0.358
2014 Birnbaum R, Jaffe AE, Hyde TM, Kleinman JE, Weinberger DR. Prenatal expression patterns of genes associated with neuropsychiatric disorders. The American Journal of Psychiatry. 171: 758-67. PMID 24874100 DOI: 10.1176/Appi.Ajp.2014.13111452  0.366
2014 Michailidi C, Soudry E, Brait M, Maldonado L, Jaffe A, Ili-Gangas C, Brebi-Mieville P, Perez J, Kim MS, Zhong X, Yang Q, Valle B, Meltzer SJ, Torbenson M, Esteller M, et al. Genome-wide and gene-specific epigenomic platforms for hepatocellular carcinoma biomarker development trials. Gastroenterology Research and Practice. 2014: 597164. PMID 24829571 DOI: 10.1155/2014/597164  0.31
2014 Jaffe AE, Irizarry RA. Accounting for cellular heterogeneity is critical in epigenome-wide association studies. Genome Biology. 15: R31. PMID 24495553 DOI: 10.1186/Gb-2014-15-2-R31  0.347
2014 Aryee MJ, Jaffe AE, Corrada-Bravo H, Ladd-Acosta C, Feinberg AP, Hansen KD, Irizarry RA. Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays. Bioinformatics (Oxford, England). 30: 1363-9. PMID 24478339 DOI: 10.1093/Bioinformatics/Btu049  0.315
2014 Fertig EJ, Stein-O'Brien G, Jaffe A, Colantuoni C. Pattern identification in time-course gene expression data with the CoGAPS matrix factorization. Methods in Molecular Biology (Clifton, N.J.). 1101: 87-112. PMID 24233779 DOI: 10.1007/978-1-62703-721-1_6  0.318
2014 Jaffe AE, Eaton WW, Straub RE, Marenco S, Weinberger DR. Paternal age, de novo mutations and schizophrenia. Molecular Psychiatry. 19: 274-5. PMID 23752248 DOI: 10.1038/Mp.2013.76  0.305
2013 Oliver VF, Franchina M, Jaffe AE, Branham KE, Othman M, Heckenlively JR, Swaroop A, Campochiaro B, Vote BJ, Craig JE, Saffery R, Mackey DA, Qian J, Zack DJ, Hewitt AW, et al. Hypomethylation of the IL17RC promoter in peripheral blood leukocytes is not a hallmark of age-related macular degeneration. Cell Reports. 5: 1527-35. PMID 24373284 DOI: 10.1016/J.Celrep.2013.11.042  0.347
2013 Jaffe AE, Storey JD, Ji H, Leek JT. Gene set bagging for estimating the probability a statistically significant result will replicate. Bmc Bioinformatics. 14: 360. PMID 24330332 DOI: 10.1186/1471-2105-14-360  0.349
2013 Gnanakkan VP, Jaffe AE, Dai L, Fu J, Wheelan SJ, Levitsky HI, Boeke JD, Burns KH. TE-array--a high throughput tool to study transposon transcription. Bmc Genomics. 14: 869. PMID 24325565 DOI: 10.1186/1471-2164-14-869  0.392
2013 Horiuchi Y, Kano S, Ishizuka K, Cascella NG, Ishii S, Talbot CC, Jaffe AE, Okano H, Pevsner J, Colantuoni C, Sawa A. Olfactory cells via nasal biopsy reflect the developing brain in gene expression profiles: utility and limitation of the surrogate tissues in research for brain disorders. Neuroscience Research. 77: 247-50. PMID 24120685 DOI: 10.1016/J.Neures.2013.09.010  0.317
2012 Jaffe AE, Murakami P, Lee H, Leek JT, Fallin MD, Feinberg AP, Irizarry RA. Bump hunting to identify differentially methylated regions in epigenetic epidemiology studies. International Journal of Epidemiology. 41: 200-9. PMID 22422453 DOI: 10.1093/Ije/Dyr238  0.549
2012 Lee H, Jaffe AE, Feinberg JI, Tryggvadottir R, Brown S, Montano C, Aryee MJ, Irizarry RA, Herbstman J, Witter FR, Goldman LR, Feinberg AP, Fallin MD. DNA methylation shows genome-wide association of NFIX, RAPGEF2 and MSRB3 with gestational age at birth. International Journal of Epidemiology. 41: 188-99. PMID 22422452 DOI: 10.1093/Ije/Dyr237  0.591
2012 Jaffe AE, Feinberg AP, Irizarry RA, Leek JT. Significance analysis and statistical dissection of variably methylated regions. Biostatistics (Oxford, England). 13: 166-78. PMID 21685414 DOI: 10.1093/Biostatistics/Kxr013  0.366
2011 Vincent A, Omura N, Hong SM, Jaffe A, Eshleman J, Goggins M. Genome-wide analysis of promoter methylation associated with gene expression profile in pancreatic adenocarcinoma. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 17: 4341-54. PMID 21610144 DOI: 10.1158/1078-0432.Ccr-10-3431  0.39
2011 Guerrero-Preston R, Soudry E, Acero J, Orera M, Moreno-López L, Macía-Colón G, Jaffe A, Berdasco M, Ili-Gangas C, Brebi-Mieville P, Fu Y, Engstrom C, Irizarry RA, Esteller M, Westra W, et al. NID2 and HOXA9 promoter hypermethylation as biomarkers for prevention and early detection in oral cavity squamous cell carcinoma tissues and saliva Cancer Prevention Research. 4: 1061-1072. PMID 21558411 DOI: 10.1158/1940-6207.Capr-11-0006  0.326
2011 Guerrero-Preston R, Soudry E, Jaffe A, Ili-Gangas C, Brebi-Mieville P, Pérez J, Zhong X, Yang Q, Meltzer SJ, Esteller M, Sidransky D. Abstract 3172: Methylation portraits discriminate between hepatocellular carcinoma cases and controls Cancer Research. 71: 3172-3172. DOI: 10.1158/1538-7445.Am2011-3172  0.351
2010 Guerrero-Preston RE, Soudry E, Ili-Gangas C, Brebi-Mieville P, Jaffe A, Barr C, Irizarry R, Berdasco M, Fu Y, Orera M, Acero J, Blanco A, Yang Q, Baez A, Esteller M, et al. Abstract 2924: Genome-wide microarray platforms uncover novel hypermethylated genes in an oral squamous cell carcinoma case-control study: A phase I preclinical biomarker development study Cancer Research. 70: 2924-2924. DOI: 10.1158/1538-7445.Am10-2924  0.381
2009 Ganesh SK, Zakai NA, van Rooij FJ, Soranzo N, Smith AV, Nalls MA, Chen MH, Kottgen A, Glazer NL, Dehghan A, Kuhnel B, Aspelund T, Yang Q, Tanaka T, Jaffe A, et al. Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium. Nature Genetics. 41: 1191-8. PMID 19862010 DOI: 10.1038/Ng.466  0.306
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