| Year |
Citation |
Score |
| 2024 |
Romero-Molina C, Neuner SM, Ryszawiec M, Pébay A, Marcora E, Goate A. Autosomal Dominant Alzheimer's Disease Mutations in Human Microglia Are Not Sufficient to Trigger Amyloid Pathology in WT Mice but Might Affect Pathology in 5XFAD Mice. International Journal of Molecular Sciences. 25. PMID 38473822 DOI: 10.3390/ijms25052565 |
0.714 |
|
| 2024 |
Telpoukhovskaia MA, Murdy TJ, Marola OJ, Charland K, MacLean M, Luquez T, Lish AM, Neuner S, Dunn A, Onos KD, Wiley J, Archer D, Huentelman MJ, Arnold M, Menon V, ... Goate A, et al. New directions for Alzheimer's disease research from the Jackson Laboratory Center for Alzheimer's and Dementia Research 2022 workshop. Alzheimer's & Dementia (New York, N. Y.). 10: e12458. PMID 38469553 DOI: 10.1002/trc2.12458 |
0.714 |
|
| 2024 |
Wang H, Chang TS, Dombroski BA, Cheng PL, Si YQ, Tucci A, Patil V, Valiente-Banuet L, Farrell K, Mclean C, Molina-Porcel L, Alex R, Paul De Deyn P, Le Bastard N, Gearing M, ... ... Goate AM, et al. Association of Structural Forms of 17q21.31 with the Risk of Progressive Supranuclear Palsy and Sub-haplotypes. Medrxiv : the Preprint Server For Health Sciences. PMID 38464214 DOI: 10.1101/2024.02.26.24303379 |
0.625 |
|
| 2024 |
Shen Y, Ali M, Timsina J, Wang C, Do A, Western D, Liu M, Gorijala P, Budde J, Liu H, Gordon B, McDade E, Morris JC, Llibre-Guerra JJ, Bateman RJ, ... ... Goate A, et al. Systematic proteomics in Autosomal dominant Alzheimer's disease reveals decades-early changes of CSF proteins in neuronal death, and immune pathways. Medrxiv : the Preprint Server For Health Sciences. PMID 38260583 DOI: 10.1101/2024.01.12.24301242 |
0.827 |
|
| 2024 |
Vance JM, Farrer LA, Huang Y, Cruchaga C, Hyman BT, Pericak-Vance MA, Goate AM, Greicius MD, Griswold AJ, Haines JL, Tcw J, Schellenberg GD, Tsai LH, Herz J, Holtzman DM. Report of the APOE4 National Institute on Aging/Alzheimer Disease Sequencing Project Consortium Working Group: Reducing APOE4 in Carriers is a Therapeutic Goal for Alzheimer's Disease. Annals of Neurology. PMID 38180638 DOI: 10.1002/ana.26864 |
0.702 |
|
| 2024 |
Wang L, Nykänen NP, Western D, Gorijala P, Timsina J, Li F, Wang Z, Ali M, Yang C, Liu M, Brock W, Marquié M, Boada M, Alvarez I, Aguilar M, ... ... Goate A, et al. Proteo-genomics of soluble TREM2 in cerebrospinal fluid provides novel insights and identifies novel modulators for Alzheimer's disease. Molecular Neurodegeneration. 19: 1. PMID 38172904 DOI: 10.1186/s13024-023-00687-4 |
0.851 |
|
| 2024 |
Sexton CE, Bitan G, Bowles KR, Brys M, Buée L, Maina MB, Clelland CD, Cohen AD, Crary JF, Dage JL, Diaz K, Frost B, Gan L, Goate AM, Golbe LI, et al. Novel avenues of tau research. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 38170841 DOI: 10.1002/alz.13533 |
0.501 |
|
| 2023 |
Wang H, Chang TS, Dombroski BA, Cheng PL, Patil V, Valiente-Banuet L, Farrell K, Mclean C, Molina-Porcel L, Rajput A, Paul De Deyn P, Le Bastard N, Gearing M, Donker Kaat L, Van Swieten JC, ... ... Goate AM, et al. Whole-Genome Sequencing Analysis Reveals New Susceptibility Loci and Structural Variants Associated with Progressive Supranuclear Palsy. Medrxiv : the Preprint Server For Health Sciences. PMID 38234807 DOI: 10.1101/2023.12.28.23300612 |
0.749 |
|
| 2023 |
Gunasekaran TI, Reyes-Dumeyer D, Faber KM, Goate A, Boeve B, Cruchaga C, Pericak-Vance M, Haines JL, Rosenberg R, Tsuang D, Mejia DR, Medrano M, Lantigua RA, Sweet RA, Bennett DA, et al. Identification of Rare Damaging Missense and Loss of Function Variants in GWAS Loci Using Genome Sequencing Data from Two Cohorts of Familial Late-Onset Alzheimer's Disease. Medrxiv : the Preprint Server For Health Sciences. PMID 38196599 DOI: 10.1101/2023.12.18.23300145 |
0.712 |
|
| 2023 |
Humphrey J, Brophy E, Kosoy R, Zeng B, Coccia E, Mattei D, Ravi A, Efthymiou AG, Navarro E, Muller BZ, Snijders GJ, Allan A, Münch A, Kitata RB, Kleopoulos SP, ... ... Goate AM, et al. Long-read RNA-seq atlas of novel microglia isoforms elucidates disease-associated genetic regulation of splicing. Medrxiv : the Preprint Server For Health Sciences. PMID 38076956 DOI: 10.1101/2023.12.01.23299073 |
0.324 |
|
| 2023 |
Wang D, Scalici A, Wang Y, Lin H, Pitsillides A, Heard-Costa N, Cruchaga C, Ziegemeier E, Bis JC, Fornage M, Boerwinkle E, De Jager PL, Wijsman E, Dupuis J, Renton AE, ... ... Goate A, et al. Frequency of Variants in Mendelian Alzheimer's Disease Genes within the Alzheimer's Disease Sequencing Project (ADSP). Medrxiv : the Preprint Server For Health Sciences. PMID 37961373 DOI: 10.1101/2023.10.24.23297227 |
0.697 |
|
| 2023 |
Shirzadi Z, Schultz SA, Yau WW, Joseph-Mathurin N, Fitzpatrick CD, Levin R, Kantarci K, Preboske GM, Jack CR, Farlow MR, Hassenstab J, Jucker M, Morris JC, Xiong C, Karch CM, ... ... Goate A, et al. Etiology of White Matter Hyperintensities in Autosomal Dominant and Sporadic Alzheimer Disease. Jama Neurology. PMID 37843849 DOI: 10.1001/jamaneurol.2023.3618 |
0.764 |
|
| 2023 |
Ralvenius WT, Mungenast AE, Woolf H, Huston MM, Gillingham TZ, Godin SK, Penney J, Cam HP, Gao F, Fernandez CG, Czako B, Lightfoot Y, Ray WJ, Beckmann A, Goate AM, et al. A novel molecular class that recruits HDAC/MECP2 complexes to PU.1 motifs reduces neuroinflammation. The Journal of Experimental Medicine. 220. PMID 37642942 DOI: 10.1084/jem.20222105 |
0.326 |
|
| 2023 |
Bertucci T, Bowles KR, Lotz S, Qi L, Stevens K, Goderie SK, Borden S, Oja LM, Lane K, Lotz R, Lotz H, Chowdhury R, Joy S, Arduini BL, Butler DC, ... ... Goate AM, et al. Improved Protocol for Reproducible Human Cortical Organoids Reveals Early Alterations in Metabolism with Mutations. Biorxiv : the Preprint Server For Biology. PMID 37503195 DOI: 10.1101/2023.07.11.548571 |
0.528 |
|
| 2023 |
Rajabli F, Benchek P, Tosto G, Kushch N, Sha J, Bazemore K, Zhu C, Lee WP, Haut J, Hamilton-Nelson KL, Wheeler NR, Zhao Y, Farrell JJ, Grunin MA, Leung YY, ... ... Goate AM, et al. Multi-ancestry genome-wide meta-analysis of 56,241 individuals identifies and nominates ancestry-specific loci , , and as novel risk loci for Alzheimer's disease: the Alzheimer's Disease Genetics Consortium. Medrxiv : the Preprint Server For Health Sciences. PMID 37461624 DOI: 10.1101/2023.07.06.23292311 |
0.843 |
|
| 2023 |
Guo L, Cao J, Hou J, Li Y, Huang M, Zhu L, Zhang L, Lee Y, Duarte ML, Zhou X, Wang M, Liu CC, Martens Y, Chao M, Goate A, et al. Sex specific molecular networks and key drivers of Alzheimer's disease. Molecular Neurodegeneration. 18: 39. PMID 37340466 DOI: 10.1186/s13024-023-00624-5 |
0.351 |
|
| 2023 |
Schultz SA, Shirzadi Z, Schultz AP, Liu L, Fitzpatrick CD, McDade E, Barthelemy NR, Renton A, Esposito B, Joseph-Mathurin N, Cruchaga C, Chen CD, Goate A, Allegri RF, Benzinger TLS, et al. Location of pathogenic variants in PSEN1 impacts progression of cognitive, clinical, and neurodegenerative measures in autosomal-dominant Alzheimer's disease. Aging Cell. e13871. PMID 37291760 DOI: 10.1111/acel.13871 |
0.755 |
|
| 2023 |
Ali M, Archer DB, Gorijala P, Western D, Timsina J, Fernández MV, Wang TC, Satizabal CL, Yang Q, Beiser AS, Wang R, Chen G, Gordon B, Benzinger TLS, Xiong C, ... ... Goate A, et al. Large multi-ethnic genetic analyses of amyloid imaging identify new genes for Alzheimer disease. Acta Neuropathologica Communications. 11: 68. PMID 37101235 DOI: 10.1186/s40478-023-01563-4 |
0.807 |
|
| 2023 |
Brase L, You SF, D'Oliveira Albanus R, Del-Aguila JL, Dai Y, Novotny BC, Soriano-Tarraga C, Dykstra T, Fernandez MV, Budde JP, Bergmann K, Morris JC, Bateman RJ, Perrin RJ, McDade E, ... ... Goate AM, et al. Single-nucleus RNA-sequencing of autosomal dominant Alzheimer disease and risk variant carriers. Nature Communications. 14: 2314. PMID 37085492 DOI: 10.1038/s41467-023-37437-5 |
0.837 |
|
| 2023 |
Chen CD, McCullough A, Gordon B, Joseph-Mathurin N, Flores S, McKay NS, Hobbs DA, Hornbeck R, Fagan AM, Cruchaga C, Goate AM, Perrin RJ, Wang G, Li Y, Shi X, et al. Longitudinal head-to-head comparison of C-PiB and F-florbetapir PET in a Phase 2/3 clinical trial of anti-amyloid-β monoclonal antibodies in dominantly inherited Alzheimer's disease. European Journal of Nuclear Medicine and Molecular Imaging. PMID 37017737 DOI: 10.1007/s00259-023-06209-0 |
0.604 |
|
| 2023 |
Kloske CM, Barnum CJ, Batista AF, Bradshaw EM, Brickman AM, Bu G, Dennison J, Gearon MD, Goate AM, Haass C, Heneka MT, Hu WT, Huggins LKL, Jones NS, Koldamova R, et al. APOE and immunity: Research highlights. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36975090 DOI: 10.1002/alz.13020 |
0.317 |
|
| 2023 |
Cochran JN, Acosta-Uribe J, Esposito BT, Madrigal L, Aguillón D, Giraldo MM, Taylor JW, Bradley J, Fulton-Howard B, Andrews SJ, Acosta-Baena N, Alzate D, Garcia GP, Piedrahita F, Lopez HE, ... ... Goate AM, et al. Genetic associations with age at dementia onset in the PSEN1 E280A Colombian kindred. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36951251 DOI: 10.1002/alz.13021 |
0.759 |
|
| 2023 |
Qiao M, Lee AJ, Reyes-Dumeyer D, Tosto G, Faber K, Goate A, Renton A, Chao M, Boeve B, Cruchaga C, Pericak-Vance M, Haines JL, Rosenberg R, Tsuang D, Sweet RA, et al. Polygenic risk score penetrance & recurrence risk in familial Alzheimer disease. Annals of Clinical and Translational Neurology. PMID 36946865 DOI: 10.1002/acn3.51757 |
0.666 |
|
| 2023 |
Andrews SJ, Renton AE, Fulton-Howard B, Podlesny-Drabiniok A, Marcora E, Goate AM. The complex genetic architecture of Alzheimer's disease: novel insights and future directions. Ebiomedicine. 90: 104511. PMID 36907103 DOI: 10.1016/j.ebiom.2023.104511 |
0.433 |
|
| 2023 |
Podlesny-Drabiniok A, Novikova G, Liu Y, Dunst J, Temizer R, Giannarelli C, Marro S, Kreslavsky T, Marcora E, Goate AM. BHLHE40/41 regulate macrophage/microglia responses associated with Alzheimer’s disease and other disorders of lipid-rich tissues. Biorxiv : the Preprint Server For Biology. PMID 36824752 DOI: 10.1101/2023.02.13.528372 |
0.311 |
|
| 2022 |
Chatterjee P, Vermunt L, Gordon BA, Pedrini S, Boonkamp L, Armstrong NJ, Xiong C, Singh AK, Li Y, Sohrabi HR, Taddei K, Molloy M, Benzinger TLS, Morris JC, Karch C, ... ... Goate A, et al. Plasma glial fibrillary acidic protein in autosomal dominant Alzheimer's disease: Associations with Aβ-PET, neurodegeneration, and cognition. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36576155 DOI: 10.1002/alz.12879 |
0.768 |
|
| 2022 |
O'Connor A, Rice H, Barnes J, Ryan NS, Liu KY, Allegri RF, Berman S, Ringman JM, Cruchaga C, Farlow MR, Hassenstab J, Lee JH, Perrin RJ, Xiong C, Gordon B, ... ... Goate A, et al. First presentation with neuropsychiatric symptoms in autosomal dominant Alzheimer's disease: the Dominantly Inherited Alzheimer's Network Study. Journal of Neurology, Neurosurgery, and Psychiatry. PMID 36522155 DOI: 10.1136/jnnp-2022-329843 |
0.658 |
|
| 2022 |
Harerimana NV, Goate AM, Bowles KR. The influence of 17q21.31 and genetic ancestry on neurodegenerative disease risk. Frontiers in Aging Neuroscience. 14: 1021918. PMID 36337698 DOI: 10.3389/fnagi.2022.1021918 |
0.309 |
|
| 2022 |
Romero-Molina C, Garretti F, Andrews SJ, Marcora E, Goate AM. Microglial efferocytosis: Diving into the Alzheimer's disease gene pool. Neuron. 110: 3513-3533. PMID 36327897 DOI: 10.1016/j.neuron.2022.10.015 |
0.423 |
|
| 2022 |
Novotny BC, Fernandez MV, Wang C, Budde JP, Bergmann K, Eteleeb AM, Bradley J, Webster C, Ebl C, Norton J, Gentsch J, Dube U, Wang F, Morris JC, Bateman RJ, ... ... Goate A, et al. Metabolomic and lipidomic signatures in autosomal dominant and late-onset Alzheimer's disease brains. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 36251323 DOI: 10.1002/alz.12800 |
0.842 |
|
| 2022 |
Whitson HE, Colton C, El Khoury J, Gate D, Goate A, Heneka MT, Kaddurah-Daouk R, Klein RS, Shinohara ML, Sisodia S, Spudich SS, Stevens B, Tanzi R, Ting JP, Garden G. Infection and inflammation: New perspectives on Alzheimer's disease. Brain, Behavior, & Immunity - Health. 22: 100462. PMID 36118272 DOI: 10.1016/j.bbih.2022.100462 |
0.337 |
|
| 2022 |
Saroja SR, Gorbachev K, Julia T, Goate AM, Pereira AC. Astrocyte-secreted glypican-4 drives APOE4-dependent tau hyperphosphorylation. Proceedings of the National Academy of Sciences of the United States of America. 119: e2108870119. PMID 35969759 DOI: 10.1073/pnas.2108870119 |
0.316 |
|
| 2022 |
Takada LT, Aláez-Verson C, Burgute BD, Nitrini R, Sosa AL, Castilhos RM, Chaves MF, Longoria EM, Carrillo-Sánchez K, Brucki SMD, Flores-Lagunes LL, Molina C, Olivares MJ, Ziegemeier E, Petranek J, ... Goate AM, et al. Discovery and validation of dominantly inherited Alzheimer's disease mutations in populations from Latin America. Alzheimer's Research & Therapy. 14: 108. PMID 35932032 DOI: 10.1186/s13195-022-01052-1 |
0.816 |
|
| 2022 |
Tcw J, Qian L, Pipalia NH, Chao MJ, Liang SA, Shi Y, Jain BR, Bertelsen SE, Kapoor M, Marcora E, Sikora E, Andrews EJ, Martini AC, Karch CM, Head E, ... ... Goate AM, et al. Cholesterol and matrisome pathways dysregulated in astrocytes and microglia. Cell. 185: 2213-2233.e25. PMID 35750033 DOI: 10.1016/j.cell.2022.05.017 |
0.58 |
|
| 2022 |
Vöglein J, Franzmeier N, Morris JC, Dieterich M, McDade E, Simons M, Preische O, Hofmann A, Hassenstab J, Benzinger TL, Fagan A, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, ... ... Goate A, et al. Patterns and implications of neurological examination findings in autosomal dominant Alzheimer disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 35609137 DOI: 10.1002/alz.12684 |
0.618 |
|
| 2022 |
Morris JC, Weiner M, Xiong C, Beckett L, Coble D, Saito N, Aisen PS, Allegri R, Benzinger TLS, Berman SB, Cairns NJ, Carrillo MC, Chui HC, Chhatwal JP, Cruchaga C, ... ... Goate AM, et al. Autosomal dominant and sporadic late onset Alzheimer disease share a common in vivo pathophysiology. Brain : a Journal of Neurology. PMID 35580594 DOI: 10.1093/brain/awac181 |
0.701 |
|
| 2022 |
Bellenguez C, Küçükali F, Jansen IE, Kleineidam L, Moreno-Grau S, Amin N, Naj AC, Campos-Martin R, Grenier-Boley B, Andrade V, Holmans PA, Boland A, Damotte V, van der Lee SJ, Costa MR, ... ... Goate AM, et al. New insights into the genetic etiology of Alzheimer's disease and related dementias. Nature Genetics. PMID 35379992 DOI: 10.1038/s41588-022-01024-z |
0.854 |
|
| 2022 |
Martens YA, Zhao N, Liu CC, Kanekiyo T, Yang AJ, Goate AM, Holtzman DM, Bu G. ApoE Cascade Hypothesis in the pathogenesis of Alzheimer's disease and related dementias. Neuron. PMID 35298921 DOI: 10.1016/j.neuron.2022.03.004 |
0.365 |
|
| 2022 |
Chen HH, Eteleeb A, Wang C, Fernandez MV, Budde JP, Bergmann K, Norton J, Wang F, Ebl C, Morris JC, Perrin RJ, Bateman RJ, McDade E, Xiong C, Goate A, et al. Circular RNA detection identifies circPSEN1 alterations in brain specific to autosomal dominant Alzheimer's disease. Acta Neuropathologica Communications. 10: 29. PMID 35246267 DOI: 10.1186/s40478-022-01328-5 |
0.823 |
|
| 2022 |
Lim YY, Maruff P, Barthélemy NR, Goate A, Hassenstab J, Sato C, Fagan AM, Benzinger TLS, Xiong C, Cruchaga C, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, et al. Association of BDNF Val66Met With Tau Hyperphosphorylation and Cognition in Dominantly Inherited Alzheimer Disease. Jama Neurology. PMID 35099506 DOI: 10.1001/jamaneurol.2021.5181 |
0.647 |
|
| 2022 |
Chhatwal JP, Schultz SA, McDade E, Schultz AP, Liu L, Hanseeuw BJ, Joseph-Mathurin N, Feldman R, Fitzpatrick CD, Sparks KP, Levin J, Berman SB, Renton AE, Esposito BT, Fernandez MV, ... ... Goate AM, et al. Variant-dependent heterogeneity in amyloid β burden in autosomal dominant Alzheimer's disease: cross-sectional and longitudinal analyses of an observational study. The Lancet. Neurology. 21: 140-152. PMID 35065037 DOI: 10.1016/S1474-4422(21)00375-6 |
0.826 |
|
| 2022 |
Machlovi SI, Neuner SM, Hemmer BM, Khan R, Liu Y, Huang M, Zhu JD, Castellano JM, Cai D, Marcora E, Goate AM. APOE4 genotype confers transcriptomic and functional alterations to primary mouse microglia. Neurobiology of Disease. 105615. PMID 35031484 DOI: 10.1016/j.nbd.2022.105615 |
0.709 |
|
| 2022 |
Reyes-Dumeyer D, Faber K, Vardarajan B, Goate A, Renton A, Chao M, Boeve B, Cruchaga C, Pericak-Vance M, Haines JL, Rosenberg R, Tsuang D, Sweet RA, Bennett DA, Wilson RS, et al. The National Institute on Aging Late-Onset Alzheimer's Disease Family Based Study: A resource for genetic discovery. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34978149 DOI: 10.1002/alz.12514 |
0.7 |
|
| 2021 |
Xue D, Bush WS, Renton AE, Marcora EA, Bis JC, Kunkle BW, Boerwinkle E, DeStefano AL, Farrer L, Goate A, Mayeux R, Pericak-Vance M, Schellenberg G, Seshadri S, et al. Large-scale sequencing studies expand the known genetic architecture of Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12255. PMID 35005195 DOI: 10.1002/dad2.12255 |
0.422 |
|
| 2021 |
Rosene MJ, Hsu S, Martinez R, Norton J, Yan P, Cirrito JR, Lee JM, Cuervo AM, Goate AM, Cruchaga C, Karch CM. Defining the role of PLD3 in Alzheimer's disease pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 17: e058730. PMID 34971168 DOI: 10.1002/alz.058730 |
0.68 |
|
| 2021 |
Bowles KR, Pugh DA, Oja LM, Jadow BM, Farrell K, Whitney K, Sharma A, Cherry JD, Raj T, Pereira AC, Crary JF, Goate AM. Dysregulated coordination of MAPT exon 2 and exon 10 splicing underlies different tau pathologies in PSP and AD. Acta Neuropathologica. PMID 34874463 DOI: 10.1007/s00401-021-02392-2 |
0.301 |
|
| 2021 |
Horgusluoglu E, Neff R, Song WM, Wang M, Wang Q, Arnold M, Krumsiek J, Galindo-Prieto B, Ming C, Nho K, Kastenmüller G, Han X, Baillie R, Zeng Q, Andrews S, ... ... Goate A, et al. Integrative metabolomics-genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34757660 DOI: 10.1002/alz.12468 |
0.391 |
|
| 2021 |
Farrell K, Kim S, Han N, Iida MA, Gonzalez EM, Otero-Garcia M, Walker JM, Richardson TE, Renton AE, Andrews SJ, Fulton-Howard B, Humphrey J, Vialle RA, Bowles KR, de Paiva Lopes K, ... ... Goate A, et al. Genome-wide association study and functional validation implicates JADE1 in tauopathy. Acta Neuropathologica. PMID 34719765 DOI: 10.1007/s00401-021-02379-z |
0.39 |
|
| 2021 |
Sexton C, Snyder H, Beher D, Boxer AL, Brannelly P, Brion JP, Buée L, Cacace AM, Chételat G, Citron M, DeVos SL, Diaz K, Feldman HH, Frost B, Goate AM, et al. Current directions in tau research: Highlights from Tau 2020. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 34581500 DOI: 10.1002/alz.12452 |
0.552 |
|
| 2021 |
Huq AJ, Fulton-Howard B, Riaz M, Laws S, Sebra R, Ryan J, Renton AE, Goate AM, Masters CL, Storey E, Shah RC, Murray A, McNeil J, Winship I, et al. Polygenic score modifies risk for Alzheimer's disease in ε4 homozygotes at phenotypic extremes. Alzheimer's & Dementia (Amsterdam, Netherlands). 13: e12226. PMID 34386572 DOI: 10.1002/dad2.12226 |
0.393 |
|
| 2021 |
Chen CD, Joseph-Mathurin N, Sinha N, Zhou A, Li Y, Friedrichsen K, McCullough A, Franklin EE, Hornbeck R, Gordon B, Sharma V, Cruchaga C, Goate A, Karch C, McDade E, et al. Comparing amyloid-β plaque burden with antemortem PiB PET in autosomal dominant and late-onset Alzheimer disease. Acta Neuropathologica. PMID 34319442 DOI: 10.1007/s00401-021-02342-y |
0.711 |
|
| 2021 |
Bowles KR, Silva MC, Whitney K, Bertucci T, Berlind JE, Lai JD, Garza JC, Boles NC, Mahali S, Strang KH, Marsh JA, Chen C, Pugh DA, Liu Y, Gordon RE, ... ... Goate AM, et al. ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids. Cell. PMID 34314701 DOI: 10.1016/j.cell.2021.07.003 |
0.556 |
|
| 2021 |
Fagan AM, Henson RL, Li Y, Boerwinkle AH, Xiong C, Bateman RJ, Goate A, Ances BM, Doran E, Christian BT, Lai F, Rosas HD, Schupf N, Krinsky-McHale S, Silverman W, et al. Comparison of CSF biomarkers in Down syndrome and autosomal dominant Alzheimer's disease: a cross-sectional study. The Lancet. Neurology. 20: 615-626. PMID 34302786 DOI: 10.1016/S1474-4422(21)00139-3 |
0.385 |
|
| 2021 |
Wu HM, Goate AM, O'Reilly PF. Heterogeneous effects of genetic risk for Alzheimer's disease on the phenome. Translational Psychiatry. 11: 406. PMID 34301914 DOI: 10.1038/s41398-021-01518-0 |
0.398 |
|
| 2021 |
Hernández D, Morgan Schlicht S, Daniszewski M, Karch CM, Goate AM, Pébay A. Generation of a gene-corrected human isogenic iPSC line from an Alzheimer's disease iPSC line carrying the London mutation in APP (V717I). Stem Cell Research. 53: 102373. PMID 34088002 DOI: 10.1016/j.scr.2021.102373 |
0.544 |
|
| 2021 |
Caballero B, Bourdenx M, Luengo E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegmann S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, ... ... Goate AM, et al. Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nature Communications. 12: 2238. PMID 33854069 DOI: 10.1038/s41467-021-22501-9 |
0.57 |
|
| 2021 |
Ewers M, Luan Y, Frontzkowski L, Neitzel J, Rubinski A, Dichgans M, Hassenstab J, Gordon BA, Chhatwal JP, Levin J, Schofield P, Benzinger TLS, Morris JC, Goate A, Karch CM, et al. Segregation of functional networks is associated with cognitive resilience in Alzheimer's disease. Brain : a Journal of Neurology. PMID 33725114 DOI: 10.1093/brain/awab112 |
0.755 |
|
| 2021 |
Novikova G, Kapoor M, Tcw J, Abud EM, Efthymiou AG, Chen SX, Cheng H, Fullard JF, Bendl J, Liu Y, Roussos P, Björkegren JL, Liu Y, Poon WW, Hao K, ... ... Goate AM, et al. Integration of Alzheimer's disease genetics and myeloid genomics identifies disease risk regulatory elements and genes. Nature Communications. 12: 1610. PMID 33712570 DOI: 10.1038/s41467-021-21823-y |
0.427 |
|
| 2021 |
Chia R, Sabir MS, Bandres-Ciga S, Saez-Atienzar S, Reynolds RH, Gustavsson E, Walton RL, Ahmed S, Viollet C, Ding J, Makarious MB, Diez-Fairen M, Portley MK, Shah Z, Abramzon Y, ... ... Goate A, et al. Genome sequencing analysis identifies new loci associated with Lewy body dementia and provides insights into its genetic architecture. Nature Genetics. PMID 33589841 DOI: 10.1038/s41588-021-00785-3 |
0.838 |
|
| 2021 |
Neff RA, Wang M, Vatansever S, Guo L, Ming C, Wang Q, Wang E, Horgusluoglu-Moloch E, Song WM, Li A, Castranio EL, Tcw J, Ho L, Goate A, Fossati V, et al. Molecular subtyping of Alzheimer's disease using RNA sequencing data reveals novel mechanisms and targets. Science Advances. 7. PMID 33523961 DOI: 10.1126/sciadv.abb5398 |
0.383 |
|
| 2020 |
Pimenova AA, Herbinet M, Gupta I, Machlovi SI, Bowles KR, Marcora E, Goate AM. Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response. Neurobiology of Disease. 105217. PMID 33301878 DOI: 10.1016/j.nbd.2020.105217 |
0.341 |
|
| 2020 |
Fulton-Howard B, Goate AM, Adelson RP, Koppel J, Gordon ML, Barzilai N, Atzmon G, Davies P, Freudenberg-Hua Y. Greater effect of polygenic risk score for Alzheimer's disease among younger cases who are apolipoprotein E-ε4 carriers. Neurobiology of Aging. PMID 33164815 DOI: 10.1016/j.neurobiolaging.2020.09.014 |
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| 2020 |
Podleśny-Drabiniok A, Marcora E, Goate AM. Microglial Phagocytosis: A Disease-Associated Process Emerging from Alzheimer's Disease Genetics. Trends in Neurosciences. PMID 33127097 DOI: 10.1016/j.tins.2020.10.002 |
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| 2020 |
Kunkle BW, Schmidt M, Klein HU, Naj AC, Hamilton-Nelson KL, Larson EB, Evans DA, De Jager PL, Crane PK, Buxbaum JD, Ertekin-Taner N, Barnes LL, Fallin MD, Manly JJ, Go RCP, ... ... Goate AM, et al. Novel Alzheimer Disease Risk Loci and Pathways in African American Individuals Using the African Genome Resources Panel: A Meta-analysis. Jama Neurology. PMID 33074286 DOI: 10.1001/jamaneurol.2020.3536 |
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| 2020 |
Andrews SJ, Fulton-Howard B, O'Reilly P, Marcora E, Goate AM. Causal Associations Between Modifiable Risk Factors and the Alzheimer's Phenome. Annals of Neurology. PMID 32996171 DOI: 10.1002/ana.25918 |
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| 2020 |
Hur JY, Frost GR, Wu X, Crump C, Pan SJ, Wong E, Barros M, Li T, Nie P, Zhai Y, Wang JC, Tcw J, Guo L, McKenzie A, Ming C, ... ... Goate A, et al. The innate immunity protein IFITM3 modulates γ-secretase in Alzheimer's disease. Nature. PMID 32879487 DOI: 10.1038/S41586-020-2681-2 |
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| 2020 |
Zhao L, Zhang Z, Rodriguez SMB, Vardarajan BN, Renton AE, Goate AM, Mayeux R, Wang GT, Leal SM. A quantitative trait rare variant nonparametric linkage method with application to age-at-onset of Alzheimer's disease. European Journal of Human Genetics : Ejhg. PMID 32740652 DOI: 10.1038/S41431-020-0703-Z |
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| 2020 |
Cao J, Huang M, Guo L, Zhu L, Hou J, Zhang L, Pero A, Ng S, El Gaamouch F, Elder G, Sano M, Goate A, Tcw J, Haroutunian V, Zhang B, et al. MicroRNA-195 rescues ApoE4-induced cognitive deficits and lysosomal defects in Alzheimer's disease pathogenesis. Molecular Psychiatry. PMID 32632205 DOI: 10.1038/S41380-020-0824-3 |
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| 2020 |
Aschenbrenner AJ, Petros J, McDade E, Wang G, Balota DA, Benzinger TL, Cruchaga C, Goate A, Xiong C, Perrin R, Fagan AM, Graff-Radford N, Ghetti B, Levin J, Weidinger E, et al. Relationships between big-five personality factors and Alzheimer's disease pathology in autosomal dominant Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 12: e12038. PMID 32587883 DOI: 10.1002/Dad2.12038 |
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| 2020 |
Neuner SM, Tcw J, Goate AM. Genetic architecture of Alzheimer's disease. Neurobiology of Disease. 104976. PMID 32565066 DOI: 10.1016/J.Nbd.2020.104976 |
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| 2020 |
Schultz SA, Strain JF, Adedokun A, Wang Q, Preische O, Kuhle J, Flores S, Keefe S, Dincer A, Ances BM, Berman SB, Brickman AM, Cash DM, Chhatwal J, Cruchaga C, ... ... Goate A, et al. Serum neurofilament light chain levels are associated with white matter integrity in autosomal dominant Alzheimer's disease. Neurobiology of Disease. 104960. PMID 32522711 DOI: 10.1016/J.Nbd.2020.104960 |
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| 2020 |
Gregory JA, Hoelzli E, Abdelaal R, Braine C, Cuevas M, Halpern M, Barretto N, Schrode N, Akbalik G, Kang K, Cheng E, Bowles K, Lotz S, Goderie S, Karch CM, ... ... Goate A, et al. Cell Type-Specific In Vitro Gene Expression Profiling of Stem Cell-Derived Neural Models. Cells. 9. PMID 32516938 DOI: 10.3390/Cells9061406 |
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| 2020 |
Meyers JL, Zhang J, Chorlian DB, Pandey AK, Kamarajan C, Wang JC, Wetherill L, Lai D, Chao M, Chan G, Kinreich S, Kapoor M, Bertelsen S, McClintick J, Bauer L, ... ... Goate A, et al. A genome-wide association study of interhemispheric theta EEG coherence: implications for neural connectivity and alcohol use behavior. Molecular Psychiatry. PMID 32433515 DOI: 10.1038/S41380-020-0777-6 |
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| 2020 |
Barthélemy NR, Li Y, Joseph-Mathurin N, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Perrin RJ, Goate AM, Morris JC, Karch CM, Xiong C, Allegri R, Mendez PC, et al. A soluble phosphorylated tau signature links tau, amyloid and the evolution of stages of dominantly inherited Alzheimer's disease. Nature Medicine. 26: 398-407. PMID 32161412 DOI: 10.1038/S41591-020-0781-Z |
0.669 |
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| 2020 |
Polimanti R, Walters RK, Johnson EC, McClintick JN, Adkins AE, Adkins DE, Bacanu SA, Bierut LJ, Bigdeli TB, Brown S, Bucholz KK, Copeland WE, Costello EJ, Degenhardt L, Farrer LA, ... ... Goate AM, et al. Leveraging genome-wide data to investigate differences between opioid use vs. opioid dependence in 41,176 individuals from the Psychiatric Genomics Consortium. Molecular Psychiatry. PMID 32099098 DOI: 10.1038/S41380-020-0677-9 |
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| 2020 |
Hsu S, Pimenova AA, Hayes K, Villa JA, Rosene MJ, Jere M, Goate AM, Karch CM. Systematic validation of variants of unknown significance in APP, PSEN1 and PSEN2. Neurobiology of Disease. 104817. PMID 32087291 DOI: 10.1016/J.Nbd.2020.104817 |
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| 2020 |
Franzmeier N, Koutsouleris N, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, Duering M, Dichgans M, Levin J, Gordon BA, Lim YY, Masters CL, Rossor M, Fox NC, et al. Predicting sporadic Alzheimer's disease progression via inherited Alzheimer's disease-informed machine-learning. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 32043733 DOI: 10.1002/Alz.12032 |
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| 2020 |
Pimenova AA, Goate AM. Novel presenilin 1 and 2 double knock-out cell line for in vitro validation of PSEN1 and PSEN2 mutations. Neurobiology of Disease. 138: 104785. PMID 32032730 DOI: 10.1016/J.Nbd.2020.104785 |
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| 2020 |
Ramdhani S, Navarro E, Udine E, Efthymiou AG, Schilder BM, Parks M, Goate A, Raj T. Tensor decomposition of stimulated monocyte and macrophage gene expression profiles identifies neurodegenerative disease-specific trans-eQTLs. Plos Genetics. 16: e1008549. PMID 32012164 DOI: 10.1371/Journal.Pgen.1008549 |
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| 2020 |
Andrews SJ, Fulton-Howard B, Goate A. Interpretation of risk loci from genome-wide association studies of Alzheimer's disease. The Lancet. Neurology. 19: 326-335. PMID 31986256 DOI: 10.1016/S1474-4422(19)30435-1 |
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| 2020 |
Aschenbrenner AJ, James BD, McDade E, Wang G, Lim YY, Benzinger TLS, Cruchaga C, Goate A, Xiong C, Perrin R, Buckles V, Allegri R, Berman SB, Chhatwal JP, Fagan A, et al. Awareness of genetic risk in the Dominantly Inherited Alzheimer Network (DIAN). Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 16: 219-228. PMID 31914221 DOI: 10.1002/Alz.12010 |
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Andrews SJ, Fulton-Howard B, Goate A. Protective Variants in Alzheimer’s Disease Current Genetic Medicine Reports. 7: 1-12. PMID 33117616 DOI: 10.1007/S40142-019-0156-2 |
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Andrews SJ, Goate A, Anstey KJ. Association between alcohol consumption and Alzheimer's disease: A Mendelian randomization study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 31786126 DOI: 10.1016/J.Jalz.2019.09.086 |
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Andrews SJ, Fulton-Howard B, Patterson C, McFall GP, Gross A, Michaelis EK, Goate A, Swerdlow RH, Pa J. Mitonuclear interactions influence Alzheimer's disease risk. Neurobiology of Aging. PMID 31784277 DOI: 10.1016/J.Neurobiolaging.2019.09.007 |
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Adelson RP, Renton AE, Li W, Barzilai N, Atzmon G, Goate AM, Davies P, Freudenberg-Hua Y. Empirical design of a variant quality control pipeline for whole genome sequencing data using replicate discordance. Scientific Reports. 9: 16156. PMID 31695094 DOI: 10.1038/S41598-019-52614-7 |
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Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, Marcora E, Farrell JJ, Zhao Y, Qu L, Ahmad S, ... ... Goate A, et al. Correction: Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Molecular Psychiatry. PMID 31636380 DOI: 10.1038/s41380-019-0529-7 |
0.62 |
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Karch CM, Kao AW, Karydas A, Onanuga K, Martinez R, Argouarch A, Wang C, Huang C, Sohn PD, Bowles KR, Spina S, Silva MC, Marsh JA, Hsu S, Pugh DA, ... ... Goate AM, et al. A Comprehensive Resource for Induced Pluripotent Stem Cells from Patients with Primary Tauopathies. Stem Cell Reports. PMID 31631020 DOI: 10.1016/J.Stemcr.2019.09.006 |
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Meyers JL, Chorlian DB, Johnson EC, Pandey AK, Kamarajan C, Salvatore JE, Aliev F, Subbie-Saenz de Viteri S, Zhang J, Chao M, Kapoor M, Hesselbrock V, Kramer J, Kuperman S, Nurnberger J, ... ... Goate A, et al. Association of Polygenic Liability for Alcohol Dependence and EEG Connectivity in Adolescence and Young Adulthood. Brain Sciences. 9. PMID 31627376 DOI: 10.3390/Brainsci9100280 |
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Andrews SJ, Goate A. Mendelian randomization indicates that TNF is not causally associated with Alzheimer's disease. Neurobiology of Aging. 84. PMID 31587925 DOI: 10.1016/J.Neurobiolaging.2019.09.003 |
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Zhao L, He Z, Zhang D, Wang GT, Renton AE, Vardarajan BN, Nothnagel M, Goate AM, Mayeux R, Leal SM. A Rare Variant Nonparametric Linkage Method for Nuclear and Extended Pedigrees with Application to Late-Onset Alzheimer Disease via WGS Data. American Journal of Human Genetics. 105: 822-835. PMID 31585107 DOI: 10.1016/J.Ajhg.2019.09.006 |
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Dumitrescu L, Barnes LL, Thambisetty M, Beecham G, Kunkle B, Bush WS, Gifford KA, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Crane PK, Resnick SM, Keene CD, Montine TJ, ... ... Goate AM, et al. Sex differences in the genetic predictors of Alzheimer's pathology. Brain : a Journal of Neurology. 142: 2581-2589. PMID 31497858 DOI: 10.1093/Brain/Awz206 |
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Rao X, Thapa KS, Chen AB, Lin H, Gao H, Reiter JL, Hargreaves KA, Ipe J, Lai D, Xuei X, Wang Y, Gu H, Kapoor M, Farris SP, Tischfield J, ... ... Goate AM, et al. Allele-specific expression and high-throughput reporter assay reveal functional genetic variants associated with alcohol use disorders. Molecular Psychiatry. PMID 31477794 DOI: 10.1038/S41380-019-0508-Z |
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Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Goate AM, et al. Author Correction: Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. PMID 31417202 DOI: 10.1038/s41588-019-0495-7 |
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Liu Y, Wang M, Marcora EM, Zhang B, Goate AM. Promoter DNA Hypermethylation-Implications for Alzheimer's Disease. Neuroscience Letters. 134403. PMID 31351091 DOI: 10.1016/J.Neulet.2019.134403 |
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Baker E, Sims R, Leonenko G, Frizzati A, Harwood JC, Grozeva D, Morgan K, Passmore P, Holmes C, Powell J, ... ... Goate AM, et al. Gene-based analysis in HRC imputed genome wide association data identifies three novel genes for Alzheimer's disease. Plos One. 14: e0218111. PMID 31283791 DOI: 10.1371/Journal.Pone.0218111 |
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Lai D, Wetherill L, Kapoor M, Johnson EC, Schwandt M, Ramchandani VA, Goldman D, Joslyn G, Rao X, Liu Y, Farris S, Mayfield RD, Dick D, Hesselbrock V, Kramer J, ... ... Goate A, et al. Genome-wide association studies of the self-rating of effects of ethanol (SRE). Addiction Biology. e12800. PMID 31270906 DOI: 10.1111/Adb.12800 |
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Marioni RE, Harris SE, Zhang Q, McRae AF, Hagenaars SP, Hill WD, Davies G, Ritchie CW, Gale CR, Starr JM, Goate AM, Porteous DJ, Yang J, Evans KL, Deary IJ, et al. Correction: GWAS on family history of Alzheimer's disease. Translational Psychiatry. 9: 161. PMID 31171767 DOI: 10.1038/S41398-019-0498-2 |
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Wetherill L, Lai D, Johnson EC, Anokhin A, Bauer L, Bucholz KK, Dick DM, Hariri AR, Hesselbrock V, Kamarajan C, Kramer J, Kuperman S, Meyers JL, Nurnberger JI, Schuckit M, ... ... Goate AM, et al. Genome-wide association study identifies loci associated with liability to alcohol and drug dependence that is associated with variability in reward-related ventral striatum activity in African- and European-Americans. Genes, Brain, and Behavior. e12580. PMID 31099175 DOI: 10.1111/Gbb.12580 |
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Lai D, Wetherill L, Bertelsen S, Carey CE, Kamarajan C, Kapoor M, Meyers JL, Anokhin AP, Bennett DA, Bucholz KK, Chang KK, De Jager PL, Dick DM, Hesselbrock V, Kramer J, ... ... Goate AM, et al. Genome-wide association studies of alcohol dependence, DSM-IV criterion count, and individual criteria. Genes, Brain, and Behavior. PMID 31090166 DOI: 10.1111/Gbb.12579 |
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Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, ... ... Goate AM, et al. A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy. Science Translational Medicine. 11. PMID 30918111 DOI: 10.1126/Scitranslmed.Aat3005 |
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Franzmeier N, Ren J, Damm A, Monté-Rubio G, Boada M, Ruiz A, Ramirez A, Jessen F, Düzel E, Rodríguez Gómez O, Benzinger T, Goate A, Karch CM, Fagan AM, McDade E, et al. The BDNF SNP modulates the association between beta-amyloid and hippocampal disconnection in Alzheimer's disease. Molecular Psychiatry. PMID 30899092 DOI: 10.1038/S41380-019-0404-6 |
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Vöglein J, Paumier K, Jucker M, Preische O, McDade E, Hassenstab J, Benzinger TL, Noble JM, Berman SB, Graff-Radford NR, Ghetti B, Farlow MR, Chhatwal J, Salloway S, Xiong C, ... ... Goate A, et al. Clinical, pathophysiological and genetic features of motor symptoms in autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 30897203 DOI: 10.1093/Brain/Awz050 |
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Kunkle BW, Grenier-Boley B, Sims R, Bis JC, Damotte V, Naj AC, Boland A, Vronskaya M, van der Lee SJ, Amlie-Wolf A, Bellenguez C, Frizatti A, Chouraki V, Martin ER, Sleegers K, ... ... Goate AM, et al. Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. Nature Genetics. 51: 414-430. PMID 30820047 DOI: 10.1038/s41588-019-0358-2 |
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Kapoor M, Wang JC, Farris SP, Liu Y, McClintick J, Gupta I, Meyers JL, Bertelsen S, Chao M, Nurnberger J, Tischfield J, Harari O, Zeran L, Hesselbrock V, Bauer L, ... ... Goate A, et al. Analysis of whole genome-transcriptomic organization in brain to identify genes associated with alcoholism. Translational Psychiatry. 9: 89. PMID 30765688 DOI: 10.1038/S41398-019-0384-Y |
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Preische O, Schultz SA, Apel A, Kuhle J, Kaeser SA, Barro C, Gräber S, Kuder-Buletta E, LaFougere C, Laske C, Vöglein J, Levin J, Masters CL, Martins R, Schofield PR, ... ... Goate AM, et al. Serum neurofilament dynamics predicts neurodegeneration and clinical progression in presymptomatic Alzheimer's disease. Nature Medicine. PMID 30664784 DOI: 10.1038/S41591-018-0304-3 |
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Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C, Surendran P, Jiang T, Adnan SD, Afaq S, Agrawal A, Altmaier E, Antoniou AC, ... ... Goate A, et al. Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci. Molecular Psychiatry. PMID 30617275 DOI: 10.1038/S41380-018-0313-0 |
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Marcora E, Kapoor M, Novikova G, Renton AE, Hao K, Goate A. P4-492: GENOME-WIDE INTEGRATION OF ALZHEIMER'S DISEASE GENETICS AND MYELOID CELL GENOMICS IDENTIFIES NOVEL RISK GENES EXPRESSED IN MICROGLIA Alzheimer's & Dementia. 15: P1502-P1502. DOI: 10.1016/J.Jalz.2019.08.038 |
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Renton AE, Charney AW, Liu Y, Wang M, Fernandez MV, Cruchaga C, Crary JF, Zhang B, Goate AM. P4-487: BRAIN SOMATIC MOSAICISM IN 17Q21.31 MAPT
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| 2019 |
Han N, Farrell KW, Renton AE, Casella A, Bowles K, Iida MA, Cortes EP, Goate AM, Crary JF. P1-144: GENOME-WIDE ASSOCIATION STUDY IN AN AUTOPSY COHORT OF PROGRESSIVE SUPRANUCLEAR PALSY Alzheimer's & Dementia. 15: P292-P292. DOI: 10.1016/J.Jalz.2019.06.699 |
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Jaworski J, Kunkle BW, Rajabli F, Adams LD, Starks TD, Goate AM, Cuccaro ML, Vance JM, Martin ER, Foroud TM, Mayeux R, Reitz C, Byrd GS, Beecham GW, Pericak-Vance MA. O3-13-02: Genome-Wide Linkage Analysis Of African-American Alzheimer Disease Families Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4697 |
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Fernandez V, Huey D, Budde JP, Farias FHG, Harari O, Norton J, Gentsch J, Morris JC, Goate A, Rademakers R, Graff-Radford NR, Boeve BF, Kauwe J, Cruchaga C, Nia-Load. O2-10-02: Whole Exome Sequencing Analysis In Early Onset Alzheimer Reveals Novel Candidate Genes Alzheimers & Dementia. 15. DOI: 10.1016/J.Jalz.2019.06.4506 |
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Edenberg H, Goate A, Liu Y, Kapoor M, Chan G, Wetherill L, Lai D, McClintick J, Hesselbrock V, Kramer J, Kuperman S, Porjesz B, Tischfield J, Foroud T. Exome Sequencing and Genomic Studies To Better Understand Alcohol Dependence European Neuropsychopharmacology. 29: S731. DOI: 10.1016/J.Euroneuro.2017.06.054 |
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Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD, Liu M, Barnes DR, Bertelsen S, Chou YL, Erzurumluoglu AM, ... ... Goate A, et al. Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use. Biological Psychiatry. PMID 30679032 DOI: 10.1016/J.Biopsych.2018.11.024 |
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| 2018 |
Walters RK, Polimanti R, Johnson EC, McClintick JN, Adams MJ, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Chou YL, ... ... Goate AM, et al. Transancestral GWAS of alcohol dependence reveals common genetic underpinnings with psychiatric disorders. Nature Neuroscience. 21: 1656-1669. PMID 30482948 DOI: 10.1038/S41593-018-0275-1 |
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| 2018 |
Joseph-Mathurin N, Su Y, Blazey TM, Jasielec M, Vlassenko A, Friedrichsen K, Gordon BA, Hornbeck RC, Cash L, Ances BM, Veale T, Cash DM, Brickman AM, Buckles V, Cairns NJ, ... ... Goate A, et al. Utility of perfusion PET measures to assess neuronal injury in Alzheimer's disease. Alzheimer's & Dementia (Amsterdam, Netherlands). 10: 669-677. PMID 30417072 DOI: 10.1016/J.Dadm.2018.08.012 |
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Rathore N, Ramani SR, Pantua H, Payandeh J, Bhangale T, Wuster A, Kapoor M, Sun Y, Kapadia SB, Gonzalez L, Zarrin AA, Goate A, Hansen DV, Behrens TW, Graham RR. Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease. Plos Genetics. 14: e1007427. PMID 30388101 DOI: 10.1371/Journal.Pgen.1007427 |
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Araque Caballero MÁ, Suárez-Calvet M, Duering M, Franzmeier N, Benzinger T, Fagan AM, Bateman RJ, Jack CR, Levin J, Dichgans M, Jucker M, Karch C, Masters CL, Morris JC, Weiner M, ... ... Goate A, et al. White matter diffusion alterations precede symptom onset in autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 30239611 DOI: 10.1093/Brain/Awy229 |
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McDade E, Wang G, Gordon BA, Hassenstab J, Benzinger TLS, Buckles V, Fagan AM, Holtzman DM, Cairns NJ, Goate AM, Marcus DS, Morris JC, Paumier K, Xiong C, Allegri R, et al. Longitudinal cognitive and biomarker changes in dominantly inherited Alzheimer disease. Neurology. PMID 30217935 DOI: 10.1212/Wnl.0000000000006277 |
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Maxwell TJ, Corcoran C, Del-Aguila JL, Budde JP, Deming Y, Cruchaga C, Goate AM, Kauwe JSK. Genome-wide association study for variants that modulate relationships between cerebrospinal fluid amyloid-beta 42, tau, and p-tau levels. Alzheimer's Research & Therapy. 10: 86. PMID 30153862 DOI: 10.1186/S13195-018-0410-Y |
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Bis JC, Jian X, Kunkle BW, Chen Y, Hamilton-Nelson KL, Bush WS, Salerno WJ, Lancour D, Ma Y, Renton AE, Marcora E, Farrell JJ, Zhao Y, Qu L, Ahmad S, ... ... Goate A, et al. Whole exome sequencing study identifies novel rare and common Alzheimer's-Associated variants involved in immune response and transcriptional regulation. Molecular Psychiatry. PMID 30108311 DOI: 10.1038/S41380-018-0112-7 |
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| 2018 |
Karch CM, Hernández D, Wang JC, Marsh J, Hewitt AW, Hsu S, Norton J, Levitch D, Donahue T, Sigurdson W, Ghetti B, Farlow M, Chhatwal J, Berman S, Cruchaga C, ... ... Goate AM, et al. Human fibroblast and stem cell resource from the Dominantly Inherited Alzheimer Network. Alzheimer's Research & Therapy. 10: 69. PMID 30045758 DOI: 10.1186/S13195-018-0400-0 |
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Hsu S, Gordon BA, Hornbeck R, Norton JB, Levitch D, Louden A, Ziegemeier E, Laforce R, Chhatwal J, Day GS, McDade E, Morris JC, Fagan AM, Benzinger TLS, Goate AM, et al. Discovery and validation of autosomal dominant Alzheimer's disease mutations. Alzheimer's Research & Therapy. 10: 67. PMID 30021643 DOI: 10.1186/S13195-018-0392-9 |
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Lim YY, Hassenstab J, Goate A, Fagan AM, Benzinger TLS, Cruchaga C, McDade E, Chhatwal J, Levin J, Farlow MR, Graff-Radford NR, Laske C, Masters CL, Salloway S, Schofield P, et al. Effect of BDNFVal66Met on disease markers in dominantly inherited AD. Annals of Neurology. PMID 30014553 DOI: 10.1002/Ana.25299 |
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Deming Y, Dumitrescu L, Barnes LL, Thambisetty M, Kunkle B, Gifford KA, Bush WS, Chibnik LB, Mukherjee S, De Jager PL, Kukull W, Huentelman M, Crane PK, Resnick SM, Keene CD, ... ... Goate AM, et al. Sex-specific genetic predictors of Alzheimer's disease biomarkers. Acta Neuropathologica. PMID 29967939 DOI: 10.1007/s00401-018-1881-4 |
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Anttila V, Bulik-Sullivan B, Finucane HK, Walters RK, Bras J, Duncan L, Escott-Price V, Falcone GJ, Gormley P, Malik R, Patsopoulos NA, Ripke S, Wei Z, Yu D, ... ... Goate AM, et al. Analysis of shared heritability in common disorders of the brain. Science (New York, N.Y.). 360. PMID 29930110 DOI: 10.1126/Science.Aap8757 |
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Prytkova I, Goate A, Hart RP, Slesinger PA. Genetics of Alcohol Use Disorder: A Role for Induced Pluripotent Stem Cells? Alcoholism, Clinical and Experimental Research. PMID 29897633 DOI: 10.1111/Acer.13811 |
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| 2018 |
Marioni RE, Harris SE, Zhang Q, McRae AF, Hagenaars SP, Hill WD, Davies G, Ritchie CW, Gale CR, Starr JM, Goate AM, Porteous DJ, Yang J, Evans KL, Deary IJ, et al. GWAS on family history of Alzheimer's disease. Translational Psychiatry. 8: 99. PMID 29777097 DOI: 10.1038/S41398-018-0150-6 |
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| 2018 |
Fernández MV, Budde J, Del-Aguila JL, Ibañez L, Deming Y, Harari O, Norton J, Morris JC, Goate AM, Cruchaga C. Evaluation of Gene-Based Family-Based Methods to Detect Novel Genes Associated With Familial Late Onset Alzheimer Disease. Frontiers in Neuroscience. 12: 209. PMID 29670507 DOI: 10.3389/fnins.2018.00209 |
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| 2018 |
Sassi C, Nalls MA, Ridge PG, Gibbs JR, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Bras J, Blumenau S, ... ... Goate AM, et al. Mendelian adult-onset leukodystrophy genes in Alzheimer's disease: critical influence of CSF1R and NOTCH3. Neurobiology of Aging. PMID 29544907 DOI: 10.1016/j.neurobiolaging.2018.01.015 |
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| 2018 |
Blue EE, Bis JC, Dorschner MO, Tsuang DW, Barral SM, Beecham G, Below JE, Bush WS, Butkiewicz M, Cruchaga C, DeStefano A, Farrer LA, Goate A, Haines J, Jaworski J, et al. Genetic Variation in Genes Underlying Diverse Dementias May Explain a Small Proportion of Cases in the Alzheimer's Disease Sequencing Project. Dementia and Geriatric Cognitive Disorders. 45: 1-17. PMID 29486463 DOI: 10.1159/000485503 |
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| 2018 |
Del-Aguila JL, Fernández MV, Schindler S, Ibanez L, Deming Y, Ma S, Saef B, Black K, Budde J, Norton J, Chasse R, Harari O, Goate A, Xiong C, et al. Assessment of the Genetic Architecture of Alzheimer's Disease Risk in Rate of Memory Decline. Journal of Alzheimer's Disease : Jad. 62: 745-756. PMID 29480181 DOI: 10.3233/Jad-170834 |
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| 2018 |
Franzmeier N, Düzel E, Jessen F, Buerger K, Levin J, Duering M, Dichgans M, Haass C, Suárez-Calvet M, Fagan AM, Paumier K, Benzinger T, Masters CL, Morris JC, Perneczky R, ... ... Goate A, et al. Left frontal hub connectivity delays cognitive impairment in autosomal-dominant and sporadic Alzheimer's disease. Brain : a Journal of Neurology. PMID 29462334 DOI: 10.1093/Brain/Awy008 |
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| 2018 |
Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Murcia JDG, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Goate AM, et al. Correction to: Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 10: 4. PMID 29329552 DOI: 10.1186/S13073-018-0516-7 |
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| 2018 |
Wang J, Alinaghi S, Tafakhori A, Sikora E, Azcona LJ, Karkheiran S, Goate A, Paisán-Ruiz C, Darvish H. Genetic screening in two Iranian families with early-onset Alzheimer's disease identified a novel PSEN1 mutation Neurobiology of Aging. 62. PMID 29175279 DOI: 10.1016/J.Neurobiolaging.2017.10.011 |
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| 2018 |
Fernandez MV, Budde JP, Del-Aguila JL, Ibanez L, Deming Y, Harari O, Li Z, Dube U, Norton J, Morris JC, Goate AM, Cruchaga C, Nia-Load, Ncrad. P2-105: Nomination Of Novel Candidate Genes For Familial Late Onset Alzheimer Disease After Evaluation Of Gene-Based Family-Based Methods Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.791 |
0.811 |
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| 2018 |
Mahali S, Hsu S, Benitez B, Martinez R, Goate AM, Karch C, Dian. O2-12-01: Lysosomal Dysfunction And Altered Tau Metabolism In Stem Cell Models Of Autosomal Dominant Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2706 |
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| 2018 |
Hassenstab J, Aschenbrenner AJ, Balota DA, McDade E, Lim Y, Fagan AM, Benzinger TLS, Cruchaga C, Goate A, Morris JC, Bateman RJ. O1-04-03: Comparing Smartphone-Administered Cognitive Assessments With Conventional Tests And Biomarkers In Sporadic And Dominantly Inherited Alzheimer Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.2350 |
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| 2018 |
Vardarajan BN, Barral S, Jaworski J, Beecham GW, Blue E, Tosto G, Reyes-Dumeyer D, Medrano M, Lantigua R, Naj AC, Thornton TA, Destefano AL, Martin ER, Wang L, Brown L, ... ... Goate AM, et al. P1-156: Gene-Based Analyses In Whole Genome Sequencing Of Familial Late-Onset Alzheimer'S Disease Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.160 |
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| 2018 |
Kunkle BW, Jaworski J, Rajabli F, Adams LD, Cuccaro ML, Vance JM, Goate AM, Martin ER, Foroud TM, Reitz C, Beecham GW, Mayeux R, Pericak-Vance MA. P1-154: Genome-Wide Linkage Analyses Of African American Families Supports Evidence Of Linkage To Chromosome 12 Alzheimers & Dementia. 14: 336. DOI: 10.1016/J.Jalz.2018.06.158 |
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| 2018 |
Dumitrescu L, Deming Y, Lu Q, Beecham GW, Kunkle BW, Del-Aguila JL, Fernandez MV, Budde JP, Fagan AM, Jager PLD, Albert MS, Moghekar A, Riemenschneider M, Petersen RC, Barnes LL, ... ... Goate AM, et al. P1-139: The Contribution Of Sex-Specific Associations In Genetic Studies Of Alzheimer'S Disease Pathology Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.142 |
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| 2018 |
Barthélemy NR, Li Y, Wang G, Fagan AM, Morris JC, Benzinger TLS, Goate A, Hassenstab J, Xiong C, Sato C, Bateman RJ, McDade E. P1-023: Mass Spectrometry-Based Measurement Of Longitudinal Csf Tau Identifies Different Phosphorylated Sites That Track Distinct Stages Of Presymptomatic Dominantly Inherited Ad Alzheimers & Dementia. 14. DOI: 10.1016/J.Jalz.2018.06.024 |
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| 2017 |
Beecham GW, Bis JC, Martin ER, Choi SH, DeStefano AL, van Duijn CM, Fornage M, Gabriel SB, Koboldt DC, Larson DE, Naj AC, Psaty BM, Salerno W, Bush WS, Foroud TM, ... ... Goate A, et al. The Alzheimer's Disease Sequencing Project: Study design and sample selection. Neurology. Genetics. 3: e194. PMID 29184913 DOI: 10.1212/Nxg.0000000000000194 |
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| 2017 |
Ridge PG, Karch CM, Hsu S, Arano I, Teerlink CC, Ebbert MTW, Gonzalez Murcia JD, Farnham JM, Damato AR, Allen M, Wang X, Harari O, Fernandez VM, Guerreiro R, Bras J, ... ... Goate AM, et al. Linkage, whole genome sequence, and biological data implicate variants in RAB10 in Alzheimer's disease resilience. Genome Medicine. 9: 100. PMID 29183403 DOI: 10.1186/S13073-017-0486-1 |
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| 2017 |
Agrawal A, Chou YL, Carey CE, Baranger DAA, Zhang B, Sherva R, Wetherill L, Kapoor M, Wang JC, Bertelsen S, Anokhin AP, Hesselbrock V, Kramer J, Lynskey MT, Meyers JL, ... ... Goate AM, et al. Genome-wide association study identifies a novel locus for cannabis dependence. Molecular Psychiatry. PMID 29112194 DOI: 10.1038/Mp.2017.200 |
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| 2017 |
Fernández MV, Kim JH, Budde JP, Black K, Medvedeva A, Saef B, Deming Y, Del-Aguila J, Ibañez L, Dube U, Harari O, Norton J, Chasse R, Morris JC, Goate A, et al. Analysis of neurodegenerative Mendelian genes in clinically diagnosed Alzheimer Disease. Plos Genetics. 13: e1007045. PMID 29091718 DOI: 10.1371/Journal.Pgen.1007045 |
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| 2017 |
Cruchaga C, Del-Aguila JL, Saef B, Black K, Fernandez MV, Budde J, Ibanez L, Kapoor M, Tosto G, Mayeux RP, Holtzman DM, Fagan AM, Morris JC, Bateman RJ, Goate AM, et al. Polygenic risk score of sporadic late-onset Alzheimer's disease reveals a shared architecture with the familial and early-onset forms. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28943286 DOI: 10.1016/J.Jalz.2017.08.013 |
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| 2017 |
Pimenova AA, Marcora E, Goate AM. A Tale of Two Genes: Microglial Apoe and Trem2. Immunity. 47: 398-400. PMID 28930654 DOI: 10.1016/J.Immuni.2017.08.015 |
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| 2017 |
Andersen AM, Pietrzak RH, Kranzler HR, Ma L, Zhou H, Liu X, Kramer J, Kuperman S, Edenberg HJ, Nurnberger JI, Rice JP, Tischfield JA, Goate A, Foroud TM, Meyers JL, et al. Polygenic Scores for Major Depressive Disorder and Risk of Alcohol Dependence. Jama Psychiatry. PMID 28813562 DOI: 10.1001/Jamapsychiatry.2017.2269 |
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| 2017 |
Tcw J, Wang M, Pimenova AA, Bowles KR, Hartley BJ, Lacin E, Machlovi SI, Abdelaal R, Karch CM, Phatnani H, Slesinger PA, Zhang B, Goate AM, Brennand KJ. An Efficient Platform for Astrocyte Differentiation from Human Induced Pluripotent Stem Cells. Stem Cell Reports. PMID 28757165 DOI: 10.1016/J.Stemcr.2017.06.018 |
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| 2017 |
Kinnunen KM, Cash DM, Poole T, Frost C, Benzinger TLS, Ahsan RL, Leung KK, Cardoso MJ, Modat M, Malone IB, Morris JC, Bateman RJ, Marcus DS, Goate A, Salloway S, et al. Presymptomatic atrophy in autosomal dominant Alzheimer's disease: A serial MRI study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28738187 DOI: 10.1016/J.Jalz.2017.06.2268 |
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| 2017 |
Sims R, van der Lee SJ, Naj AC, Bellenguez C, Badarinarayan N, Jakobsdottir J, Kunkle BW, Boland A, Raybould R, Bis JC, Martin ER, Grenier-Boley B, Heilmann-Heimbach S, Chouraki V, Kuzma AB, ... ... Goate AM, et al. Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. Nature Genetics. PMID 28714976 DOI: 10.1038/Ng.3916 |
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| 2017 |
Pimenova AA, Raj T, Goate AM. Untangling Genetic Risk for Alzheimer's Disease. Biological Psychiatry. PMID 28666525 DOI: 10.1016/J.Biopsych.2017.05.014 |
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| 2017 |
Huang KL, Marcora E, Pimenova AA, Di Narzo AF, Kapoor M, Jin SC, Harari O, Bertelsen S, Fairfax BP, Czajkowski J, Chouraki V, Grenier-Boley B, Bellenguez C, Deming Y, McKenzie A, ... ... Goate AM, et al. A common haplotype lowers PU.1 expression in myeloid cells and delays onset of Alzheimer's disease. Nature Neuroscience. PMID 28628103 DOI: 10.1038/Nn.4587 |
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| 2017 |
Efthymiou AG, Goate AM. Late onset Alzheimer's disease genetics implicates microglial pathways in disease risk. Molecular Neurodegeneration. 12: 43. PMID 28549481 DOI: 10.1186/S13024-017-0184-X |
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| 2017 |
Desikan RS, Fan CC, Wang Y, Schork AJ, Cabral HJ, Cupples LA, Thompson WK, Besser L, Kukull WA, Holland D, Chen CH, Brewer JB, Karow DS, Kauppi K, Witoelar A, ... ... Goate AM, et al. Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score. Plos Medicine. 14: e1002258. PMID 28323831 DOI: 10.1371/Journal.Pmed.1002258 |
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| 2017 |
Deming Y, Li Z, Kapoor M, Harari O, Del-Aguila JL, Black K, Carrell D, Cai Y, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Huang KL, Bertelsen S, ... ... Goate AM, et al. Genome-wide association study identifies four novel loci associated with Alzheimer's endophenotypes and disease modifiers. Acta Neuropathologica. PMID 28247064 DOI: 10.1007/s00401-017-1685-y |
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| 2017 |
Day GS, Lim TS, Hassenstab J, Goate AM, Grant EA, Roe CM, Cairns NJ, Morris JC. Differentiating cognitive impairment due to corticobasal degeneration and Alzheimer disease. Neurology. PMID 28235814 DOI: 10.1212/Wnl.0000000000003770 |
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| 2017 |
Tosto G, Bird TD, Tsuang D, Bennett DA, Boeve BF, Cruchaga C, Faber K, Foroud TM, Farlow M, Goate AM, Bertlesen S, Graff-Radford NR, Medrano M, Lantigua R, Manly J, et al. Polygenic risk scores in familial Alzheimer disease. Neurology. PMID 28213371 DOI: 10.1212/Wnl.0000000000003734 |
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Jun GR, Chung J, Mez J, Barber R, Beecham GW, Bennett DA, Buxbaum JD, Byrd GS, Carrasquillo MM, Crane PK, Cruchaga C, De Jager P, Ertekin-Taner N, Evans D, Fallin MD, ... ... Goate AM, et al. Transethnic genome-wide scan identifies novel Alzheimer's disease loci. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 28183528 DOI: 10.1016/J.Jalz.2016.12.012 |
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He Z, Zhang D, Renton AE, Li B, Zhao L, Wang GT, Goate AM, Mayeux R, Leal SM. The Rare-Variant Generalized Disequilibrium Test for Association Analysis of Nuclear and Extended Pedigrees with Application to Alzheimer Disease WGS Data. American Journal of Human Genetics. 100: 371. PMID 28157542 DOI: 10.1016/J.Ajhg.2017.01.029 |
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| 2017 |
Haddick PC, Larson JL, Rathore N, Bhangale TR, Phung QT, Srinivasan K, Hansen DV, Lill JR, Pericak-Vance MA, Haines J, Farrer LA, Kauwe JS, Schellenberg GD, Cruchaga C, ... Goate AM, et al. A Common Variant of IL-6R is Associated with Elevated IL-6 Pathway Activity in Alzheimer's Disease Brains. Journal of Alzheimer's Disease : Jad. PMID 28106546 DOI: 10.3233/Jad-160524 |
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Meyers JL, Zhang J, Wang JC, Su J, Kuo SI, Kapoor M, Wetherill L, Bertelsen S, Lai D, Salvatore JE, Kamarajan C, Chorlian D, Agrawal A, Almasy L, Bauer L, ... ... Goate A, et al. An endophenotype approach to the genetics of alcohol dependence: a genome wide association study of fast beta EEG in families of African ancestry. Molecular Psychiatry. PMID 28070124 DOI: 10.1038/Mp.2016.239 |
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McDade E, Wang G, Benzinger TL, Buckles VD, Fagan AM, Gordon BA, Hassenstab J, Holtzman DM, Cairns NJ, Goate AM, Marcus DS, Morris JC, Paumier KL, Xiong C, Ricardo A, et al. LONGITUDINAL BIOMARKER CHANGES IN AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE FROM THE DIAN STUDY Alzheimer's & Dementia. 13: P879-P880. DOI: 10.1016/J.Jalz.2017.07.265 |
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| 2017 |
Karch C, Hsu S, Martinez R, Norton J, Cirrito JR, Lee J, Cuervo M, Cruchaga C, Goate A. [O2-18-02]: PHOSPHOLIPASE D3 CONTRIBUTES TO ALZHEIMER's DISEASE RISK VIA DISRUPTION OF Aβ CLEARANCE THROUGH THE LYSOSOME Alzheimer's & Dementia. 13: P602-P603. DOI: 10.1016/J.Jalz.2017.07.248 |
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| 2017 |
Fernandez V, Budde JP, Saef B, Del-Aguila JL, Norton J, Chasse R, Morris JC, Goate A, Cruchaga C. Novel Candidate Variants In Load Detected By The Familial Alzheimer Sequencing (Fase) Project Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.07.190 |
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| 2017 |
Deming Y, Kapoor M, Li Z, Harari O, Black K, Del-Aguila JL, Carrell D, Cai Y, Fernandez MV, Budde JP, Ma S, Saef B, Howells B, Huang K, Bertelsen S, ... ... Goate AM, et al. CEREBROSPINAL FLUID ENDOPHENOTYPES PROVIDE INSIGHT INTO BIOLOGY UNDERLYING ALZHEIMER'S DISEASE Alzheimer's & Dementia. 13: P218-P219. DOI: 10.1016/J.Jalz.2017.07.096 |
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| 2017 |
Hanseeuw BJ, McDade E, Schultz AP, Martins RN, Schofield PR, Masters CL, Graff-Radford NR, Salloway S, Danek A, Levin J, Buckles V, Goate AM, Benzinger TL, Morris JC, Bateman RJ, et al. GENOTYPIC VARIANCE MAY EXPLAIN THE BALANCE OF EARLY CORTICAL VERSUS STRIATAL AMYLOID DEPOSITION IN AUTOSOMAL DOMINANT AD Alzheimer's & Dementia. 13: P187-P188. DOI: 10.1016/J.Jalz.2017.07.043 |
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| 2017 |
Lim YY, Hassenstab J, Cruchaga C, Goate AM, Fagan AM, Benzinger TLS, Maruff P, Masters CL, McDade E, Morris JC, Bateman RJ. Bdnf Val66Met Increases Rate Of Memory Decline, Hippocampal Volume Loss And Tau Accumulation In Autosomal Dominant Alzheimer’S Disease Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.283 |
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| 2017 |
Joseph-Mathurin N, Kantarci K, Jack CR, Ringman JM, Salloway S, McDade E, Clifford D, Blazey T, Friedrichsen KA, Su Y, Gordon BA, Hornbeck RC, Mills S, Ances BM, Raichle ME, ... ... Goate A, et al. Clinical Risk Related To Cerebral Microhemorrhages In Autosomal Dominant Alzheimer’S Disease: Longitudinal Results From The Dian Study Alzheimers & Dementia. 13: 47. DOI: 10.1016/J.Jalz.2017.06.2330 |
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| 2017 |
Joseph-Mathurin N, Su Y, Blazey T, Jasielec MS, Vlassenko AG, Friedrichsen KA, Gordon BA, Hornbeck RC, Cash L, Ances BM, Raichle ME, Brickman AM, Buckles V, Cairns NJ, Cruchaga C, ... ... Goate A, et al. Utility Of Perfusion Pet Models As Measures Of Neurodegeneration In An Autosomal Dominant Alzheimer’S Disease Population: Report From The Dian Study Alzheimers & Dementia. 13. DOI: 10.1016/J.Jalz.2017.06.1027 |
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| 2016 |
Deming Y, Xia J, Cai Y, Lord J, Del-Aguila JL, Fernandez MV, Carrell D, Black K, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Bailey M, Ridge PG, ... ... Goate A, et al. Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits. Scientific Reports. 6: 18092. PMID 36647296 DOI: 10.1038/srep18092 |
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| 2016 |
Meyers JL, Zhang J, Manz N, Rangaswamy M, Kamarajan C, Wetherill L, Chorlian DB, Kang SJ, Bauer L, Hesselbrock V, Kramer J, Kuperman S, Nurnberger JI, Tischfield J, Wang JC, ... ... Goate A, et al. A Genome Wide Association Study of Fast Beta EEG in Families of European Ancestry. International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology. PMID 28040410 DOI: 10.1016/J.Ijpsycho.2016.12.008 |
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| 2016 |
Olfson E, Bloom J, Bertelsen S, Budde JP, Breslau N, Brooks A, Culverhouse R, Chan G, Chen LS, Chorlian D, Dick DM, Edenberg HJ, Hartz S, Hatsukami D, Hesselbrock VM, ... ... Goate A, et al. CYP2A6 metabolism in the development of smoking behaviors in young adults. Addiction Biology. PMID 28032407 DOI: 10.1111/Adb.12477 |
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Tcw J, Goate AM. Genetics of β-Amyloid Precursor Protein in Alzheimer's Disease. Cold Spring Harbor Perspectives in Medicine. PMID 28003277 DOI: 10.1101/Cshperspect.A024539 |
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| 2016 |
Chapuis J, Flaig A, Grenier-Boley B, Eysert F, Pottiez V, Deloison G, Vandeputte A, Ayral AM, Mendes T, Desai S, Goate AM, Kauwe JS, Leroux F, Herledan A, Demiautte F, et al. Genome-wide, high-content siRNA screening identifies the Alzheimer's genetic risk factor FERMT2 as a major modulator of APP metabolism. Acta Neuropathologica. PMID 27933404 DOI: 10.1007/S00401-016-1652-Z |
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| 2016 |
Monsell SE, Mock C, Fardo DW, Bertelsen S, Cairns NJ, Roe CM, Ellingson SR, Morris JC, Goate AM, Kukull WA. Genetic Comparison of Symptomatic and Asymptomatic Persons With Alzheimer Disease Neuropathology. Alzheimer Disease and Associated Disorders. PMID 27849641 DOI: 10.1097/Wad.0000000000000179 |
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| 2016 |
Deming Y, Black K, Carrell D, Cai Y, Del-Aguila JL, Fernandez MV, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Huang KL, Sutphen CL, Tarawneh R, Fagan AM, ... ... Goate AM, et al. Chitinase-3-like 1 protein (CHI3L1) locus influences cerebrospinal fluid levels of YKL-40. Bmc Neurology. 16: 217. PMID 27832767 DOI: 10.1186/S12883-016-0742-9 |
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| 2016 |
Wang M, Roussos P, McKenzie A, Zhou X, Kajiwara Y, Brennand KJ, De Luca GC, Crary JF, Casaccia P, Buxbaum JD, Ehrlich M, Gandy S, Goate A, Katsel P, Schadt E, et al. Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer's disease. Genome Medicine. 8: 104. PMID 27799057 DOI: 10.1186/S13073-016-0355-3 |
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Tang M, Ryman DC, McDade E, Jasielec MS, Buckles VD, Cairns NJ, Fagan AM, Goate A, Marcus DS, Xiong C, Allegri RF, Chhatwal JP, Danek A, Farlow MR, Fox NC, et al. Neurological manifestations of autosomal dominant familial Alzheimer's disease: a comparison of the published literature with the Dominantly Inherited Alzheimer Network observational study (DIAN-OBS). The Lancet. Neurology. PMID 27777020 DOI: 10.1016/S1474-4422(16)30229-0 |
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Mez J, Chung J, Jun G, Kriegel J, Bourlas AP, Sherva R, Logue MW, Barnes LL, Bennett DA, Buxbaum JD, Byrd GS, Crane PK, Ertekin-Taner N, Evans D, Fallin MD, ... ... Goate A, et al. Two novel loci, COBL and SLC10A2, for Alzheimer's disease in African Americans. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 27770636 DOI: 10.1016/J.Jalz.2016.09.002 |
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| 2016 |
Fernández MV, Black K, Carrell D, Saef B, Budde J, Deming Y, Howells B, Del-Aguila JL, Ma S, Bi C, Norton J, Chasse R, Morris J, Goate A, Cruchaga C, et al. SORL1 variants across Alzheimer's disease European American cohorts. European Journal of Human Genetics : Ejhg. PMID 27650968 DOI: 10.1038/Ejhg.2016.122 |
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Tosto G, Bird TD, Bennett DA, Boeve BF, Brickman AM, Cruchaga C, Faber K, Foroud TM, Farlow M, Goate AM, Graff-Radford NR, Lantigua R, Manly J, Ottman R, Rosenberg R, et al. The Role of Cardiovascular Risk Factors and Stroke in Familial Alzheimer Disease. Jama Neurology. PMID 27533593 DOI: 10.1001/Jamaneurol.2016.2539 |
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Lim YY, Hassenstab J, Cruchaga C, Goate A, Fagan AM, Benzinger TL, Maruff P, Snyder PJ, Masters CL, Allegri R, Chhatwal J, Farlow MR, Graff-Radford NR, Laske C, Levin J, et al. BDNF Val66Met moderates memory impairment, hippocampal function and tau in preclinical autosomal dominant Alzheimer's disease. Brain : a Journal of Neurology. PMID 27521573 DOI: 10.1093/Brain/Aww200 |
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Day GS, Musiek ES, Roe CM, Norton J, Goate AM, Cruchaga C, Cairns NJ, Morris JC. Phenotypic Similarities Between Late-Onset Autosomal Dominant and Sporadic Alzheimer Disease: A Single-Family Case-Control Study. Jama Neurology. PMID 27454811 DOI: 10.1016/J.Jalz.2016.06.1371 |
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Ebbert MT, Staley LA, Parker J, Parker S, Bailey M, Ridge PG, Goate AM, Kauwe JS. Variants in CCL16 are associated with blood plasma and cerebrospinal fluid CCL16 protein levels. Bmc Genomics. 17: 437. PMID 27357396 DOI: 10.1186/S12864-016-2788-X |
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Staley LA, Ebbert MT, Bunker D, Bailey M, Ridge PG, Goate AM, Kauwe JS. Variants in ACPP are associated with cerebrospinal fluid Prostatic Acid Phosphatase levels. Bmc Genomics. 17: 439. PMID 27357282 DOI: 10.1186/S12864-016-2787-Y |
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Staley LA, Ebbert MT, Parker S, Bailey M, Ridge PG, Goate AM, Kauwe JS. Genome-wide association study of prolactin levels in blood plasma and cerebrospinal fluid. Bmc Genomics. 17: 436. PMID 27357110 DOI: 10.1186/S12864-016-2785-0 |
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Kauwe JS, Goate A. Genes for a 'Wellderly' Life. Trends in Molecular Medicine. PMID 27312143 DOI: 10.1016/J.Molmed.2016.05.011 |
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Sassi C, Nalls MA, Ridge PG, Gibbs JR, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Clement N, Lord J, Turton J, Bras J, ... ... Goate AM, et al. ABCA7 p.G215S as potential protective factor for Alzheimer's disease. Neurobiology of Aging. PMID 27289440 DOI: 10.1016/J.Neurobiolaging.2016.04.004 |
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Sassi C, Ridge PG, Nalls MA, Gibbs R, Ding J, Lupton MK, Troakes C, Lunnon K, Al-Sarraj S, Brown KS, Medway C, Lord J, Turton J, Morgan K, ... ... Goate AM, et al. Influence of Coding Variability in APP-Aβ Metabolism Genes in Sporadic Alzheimer's Disease. Plos One. 11: e0150079. PMID 27249223 DOI: 10.1371/Journal.Pone.0150079 |
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| 2016 |
Lee S, Viqar F, Zimmerman ME, Narkhede A, Tosto G, Benzinger TL, Marcus DS, Fagan AM, Goate A, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, et al. White matter hyperintensities are a core feature of Alzheimer's disease: Evidence from the Dominantly Inherited Alzheimer Network. Annals of Neurology. PMID 27016429 DOI: 10.1002/ana.24647 |
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Kapoor M, Chou YL, Edenberg HJ, Foroud T, Martin NG, Madden PA, Wang JC, Bertelsen S, Wetherill L, Brooks A, Chan G, Hesselbrock V, Kuperman S, Medland SE, Montgomery G, ... ... Goate AM, et al. Genome-wide polygenic scores for age at onset of alcohol dependence and association with alcohol-related measures. Translational Psychiatry. 6: e761. PMID 27003187 DOI: 10.1038/Tp.2016.27 |
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Karch CM, Ezerskiy LA, Bertelsen S, Goate AM. Alzheimer's Disease Risk Polymorphisms Regulate Gene Expression in the ZCWPW1 and the CELF1 Loci. Plos One. 11: e0148717. PMID 26919393 DOI: 10.1371/Journal.Pone.0148717 |
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Deming Y, Xia J, Cai Y, Lord J, Del-Aguila JL, Fernandez MV, Carrell D, Black K, Budde J, Ma S, Saef B, Howells B, Bertelsen S, Bailey M, Ridge PG, ... ... Goate A, et al. Genetic studies of plasma analytes identify novel potential biomarkers for several complex traits Scientific Reports. 6. DOI: 10.1038/Srep18092 |
0.8 |
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| 2016 |
Petros J, Hassenstab J, Snitz BE, Zhou Y, Ringman JM, McDade E, Wang G, Balota DA, Aschenbrenner AJ, Benzinger TL, Cruchaga C, Fagan AM, Goate AM, Holtzman DM, Buckles V, et al. Dynamic Relationships Between “Big Five” Personality Traits, Alzheimer’S Disease Biomarkers, And Cognition In Autosomal Dominant Alzheimer’S Disease Alzheimers & Dementia. 12. DOI: 10.1016/J.Jalz.2016.06.970 |
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| 2016 |
McDade E, Weng H, Wang G, Xiong C, Fagan AM, Hassenstab J, Marcus DS, Morris JC, Benzinger TL, Cairns NJ, Goate AM, Buckles V, Holtzman DM, Berman S, Ghetti B, et al. O5-02-01: Longitudinal Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease: The Dominantly Inherited Alzheimer Network Alzheimer's & Dementia. 12: P378-P379. DOI: 10.1016/J.Jalz.2016.06.710 |
0.423 |
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| 2016 |
Lim YY, Hassenstab J, Cruchaga C, Goate AM, Fagan AM, Lee Smith Benzinger T, Maruff P, Snyder PJ, Masters CL, Ricardo A, Chhatwal JP, Farlow MR, Graff-Radford NR, Laske C, Levin J, et al. F5-02-03: BDNF VAL66MET Moderates Cognitive Impairment, Neuronal Dysfunction and TAU in Preclinical Autosomal Dominant Alzheimer's Disease Alzheimer's & Dementia. 12: P369-P369. DOI: 10.1016/J.Jalz.2016.06.689 |
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| 2016 |
Huang K, Jin SC, Harari O, Kapoor M, Bertelsen S, Czajkowski J, Lambert j, Chouraki V, Bellenguez C, Grenier-Boley B, Deming Y, McKenzie A, Renton AE, Budde J, Del-Aguila JL, ... ... Goate AM, et al. A Common Allele In Spi1 Lowers Risk And Delays Age At Onset For Alzheimer'S Disease Alzheimers & Dementia. 12: 253. DOI: 10.1016/J.Jalz.2016.06.453 |
0.833 |
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| 2016 |
Deming Y, Harari O, Black K, Carrell D, Cai Y, Del-Aguila JL, Fernandez V, Budde J, Ma S, Saef B, Bertelsen S, Kauwe J, Fagan AM, Holtzman DM, Morris JC, ... ... Goate AM, et al. Cerebrospinal Fluid Levels Of Amyloid Beta And Tau As Endophenotypes Reveal Novel Variants Potentially Informative For Alzheimer'S Disease Alzheimers & Dementia. 12: 252. DOI: 10.1016/J.Jalz.2016.06.452 |
0.828 |
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| 2016 |
Lee S, Zimmerman ME, Viqar F, Narkhede A, Tosto G, Lee Smith Benzinger T, Marcus DS, Goate AM, Fox NC, Cairns NJ, Holtzman DM, Buckles V, Ghetti B, McDade E, Martins RN, et al. O2-03-02: are White Matter Hyperintensities a Core Feature of Alzheimer’s Disease or Just a Reflection of Amyloid Angiopathy? Evidence From the Dominantly Inherited Alzheimer Network (DIAN) Alzheimer's & Dementia. 12: P226-P226. DOI: 10.1016/J.Jalz.2016.06.406 |
0.372 |
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| 2016 |
Fernández MV, Budde J, Saef B, Carrell D, Howells B, Del-Aguila JL, Ma S, Norton J, Chasse R, Morris JC, Goate A, Cruchaga C. Novel Rare Variants In Known Genes, A Look Into The Familial Alzheimer Sequencing (Fase) Project Alzheimers & Dementia. 12: 198. DOI: 10.1016/J.Jalz.2016.06.345 |
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| 2016 |
Marcora E, Renton AE, Beecham GW, Boerwinkle E, Cantwell L, Cruchaga C, Cweibel R, Felsenfeld A, Fornage M, Kapoor M, Kauwe K, Khaladkar M, Kobolt D, Ma Y, Mayeux R, ... ... Goate AM, et al. F1-01-02: Alzheimer's Disease Sequencing Project: Search for Alzheimer's Disease Resilience Genes That May Modify Disease Susceptibility in Specific Apoe Genotype Backgrounds Alzheimer's & Dementia. 12: P162-P163. DOI: 10.1016/J.Jalz.2016.06.272 |
0.714 |
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| 2016 |
Fernández MV, Black K, Carrell D, Saef B, Budde J, Deming Y, Howells B, Del-Aguila JL, Ma S, Norton J, Chasse R, Morris JC, Goate A, Cruchaga C. Sorl1 Variants Across Alzheimer’S Disease Cohorts In European Americans Alzheimers & Dementia. 12: 857. DOI: 10.1016/J.Jalz.2016.06.1756 |
0.814 |
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| 2016 |
Kauwe K, Arano I, Bras JT, Cannon-Albright L, Cruchaga C, Goate AM, Murcia JDG, Guerreiro R, Hardy J, Hsu S, Karch C, Munger RG, Norton MC, Ridge PG, Sassi C, et al. Linkage And Whole Genome Sequence Analysis Of Alzheimer'S Disease Resilience And Risk Alzheimers & Dementia. 12: 675. DOI: 10.1016/J.Jalz.2016.06.1325 |
0.83 |
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| 2016 |
Marcora E, Renton AE, Beecham GW, Boerwinkle E, Cantwell L, Cruchaga C, Cweibel R, Felsenfeld A, Fornage M, Kapoor M, Kauwe K, Khaladkar M, Kobolt D, Ma Y, Mayeux R, ... ... Goate AM, et al. P2-077: Alzheimer's Disease Sequencing Project: Search for Alzheimer's Disease Resilience Genes That May Modify Disease Susceptibility in Specific Apoe
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Haller G, Alvarado D, McCall K, Yang P, Cruchaga C, Harms M, Goate A, Willing M, Morcuende JA, Baschal E, Miller NH, Wise C, Dobbs MB, Gurnett CA. A polygenic burden of rare variants across extracellular matrix genes among individuals with adolescent idiopathic scoliosis. Human Molecular Genetics. PMID 26566670 DOI: 10.1093/Hmg/Ddv463 |
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Barral S, Cheng R, Reitz C, Vardarajan B, Lee J, Kunkle B, Beecham G, Cantwell LS, Pericak-Vance MA, Farrer LA, Haines JL, Goate AM, Foroud T, Boerwinkle E, Schellenberg GD, et al. Linkage analyses in Caribbean Hispanic families identify novel loci associated with familial late-onset Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26433351 DOI: 10.1016/J.Jalz.2015.07.487 |
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Ghani M, Reitz C, Cheng R, Vardarajan BN, Jun G, Sato C, Naj A, Rajbhandary R, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, ... ... Goate AM, et al. Association of Long Runs of Homozygosity With Alzheimer Disease Among African American Individuals. Jama Neurology. PMID 26366463 DOI: 10.1001/Jamaneurol.2015.1700 |
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Kunkle BW, Jaworski J, Barral S, Vardarajan B, Beecham GW, Martin ER, Cantwell LS, Partch A, Bird TD, Raskind WH, DeStefano AL, Carney RM, Cuccaro M, Vance JM, Farrer LA, ... Goate AM, et al. Genome-wide linkage analyses of non-Hispanic white families identify novel loci for familial late-onset Alzheimer's disease. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26365416 DOI: 10.1016/J.Jalz.2015.05.020 |
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Barral S, Vardarajan BN, Reyes-Dumeyer D, Faber KM, Bird TD, Tsuang D, Bennett DA, Rosenberg R, Boeve BF, Graff-Radford NR, Goate AM, Farlow M, Lantigua R, Medrano MZ, Wang X, et al. Genetic variants associated with susceptibility to psychosis in late-onset Alzheimer's disease families. Neurobiology of Aging. 36: 3116.e9-3116.e16. PMID 26359528 DOI: 10.1016/J.Neurobiolaging.2015.08.006 |
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Sadler B, Haller G, Edenberg H, Tischfield J, Brooks A, Kramer J, Schuckit M, Nurnberger J, Goate A. Positive Selection on Loci Associated with Drug and Alcohol Dependence. Plos One. 10: e0134393. PMID 26270548 DOI: 10.1371/Journal.Pone.0134393 |
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Olfson E, Saccone NL, Johnson EO, Chen LS, Culverhouse R, Doheny K, Foltz SM, Fox L, Gogarten SM, Hartz S, Hetrick K, Laurie CC, Marosy B, Amin N, Arnett D, ... ... Goate A, et al. Rare, low frequency and common coding variants in CHRNA5 and their contribution to nicotine dependence in European and African Americans. Molecular Psychiatry. PMID 26239294 DOI: 10.1038/Mp.2015.105 |
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Nelson EC, Agrawal A, Heath AC, Bogdan R, Sherva R, Zhang B, Al-Hasani R, Bruchas MR, Chou YL, Demers CH, Carey CE, Conley ED, Fakira AK, Farrer LA, Goate A, et al. Evidence of CNIH3 involvement in opioid dependence. Molecular Psychiatry. PMID 26239289 DOI: 10.1038/Mp.2015.102 |
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Hancock DB, Wang JC, Gaddis NC, Levy JL, Saccone NL, Stitzel JA, Goate A, Bierut LJ, Johnson EO. A multiancestry study identifies novel genetic associations with CHRNA5 methylation in human brain and risk of nicotine dependence. Human Molecular Genetics. PMID 26220977 DOI: 10.1093/Hmg/Ddv303 |
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Hohman TJ, Cooke-Bailey JN, Reitz C, Jun G, Naj A, Beecham GW, Liu Z, Carney RM, Vance JM, Cuccaro ML, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, ... ... Goate AM, et al. Global and local ancestry in African-Americans: Implications for Alzheimer's disease risk. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 26092349 DOI: 10.1016/J.Jalz.2015.02.012 |
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Patterson BW, Elbert DL, Mawuenyega KG, Kasten T, Ovod V, Ma S, Xiong C, Chott R, Yarasheski K, Sigurdson W, Zhang L, Goate A, Benzinger T, Morris JC, Holtzman D, et al. Age and amyloid effects on human CNS amyloid-beta kinetics. Annals of Neurology. PMID 26040676 DOI: 10.1002/Ana.24454 |
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Jin SC, Carrasquillo MM, Benitez BA, Skorupa T, Carrell D, Patel D, Lincoln S, Krishnan S, Kachadoorian M, Reitz C, Mayeux R, Wingo TS, Lah JJ, Levey AI, Murrell J, ... ... Goate AM, et al. TREM2 is associated with increased risk for Alzheimer's disease in African Americans. Molecular Neurodegeneration. 10: 19. PMID 25886450 DOI: 10.1186/S13024-015-0016-9 |
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Cruchaga C, Goate AM. Cruchaga & Goate reply. Nature. 520: E5-6. PMID 25832412 DOI: 10.1038/Nature14037 |
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Cruchaga C, Goate AM. Cruchaga & Goate reply. Nature. 520: E10. PMID 25832409 DOI: 10.1038/nature14041 |
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Kim A, Fagan AM, Goate AM, Benzinger TL, Morris JC, Head D. Lack of an association of BDNF Val66Met polymorphism and plasma BDNF with hippocampal volume and memory. Cognitive, Affective & Behavioral Neuroscience. PMID 25784293 DOI: 10.3758/S13415-015-0343-X |
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Jun G, Ibrahim-Verbaas CA, Vronskaya M, Lambert JC, Chung J, Naj AC, Kunkle BW, Wang LS, Bis JC, Bellenguez C, Harold D, Lunetta KL, Destefano AL, Grenier-Boley B, Sims R, ... ... Goate AM, et al. A novel Alzheimer disease locus located near the gene encoding tau protein. Molecular Psychiatry. PMID 25778476 DOI: 10.1038/Mp.2015.23 |
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Bailey HR, Sargent JQ, Flores S, Nowotny P, Goate A, Zacks JM. APOE ε4 genotype predicts memory for everyday activities. Neuropsychology, Development, and Cognition. Section B, Aging, Neuropsychology and Cognition. 1-28. PMID 25754878 DOI: 10.1080/13825585.2015.1020916 |
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Ringman JM, Liang LJ, Zhou Y, Vangala S, Teng E, Kremen S, Wharton D, Goate A, Marcus DS, Farlow M, Ghetti B, McDade E, Masters CL, Mayeux RP, Rossor M, et al. Early behavioural changes in familial Alzheimer's disease in the Dominantly Inherited Alzheimer Network. Brain : a Journal of Neurology. 138: 1036-45. PMID 25688083 DOI: 10.1093/Brain/Awv004 |
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Wang LS, Naj AC, Graham RR, Crane PK, Kunkle BW, Cruchaga C, Murcia JD, Cannon-Albright L, Baldwin CT, Zetterberg H, Blennow K, Kukull WA, Faber KM, Schupf N, Norton MC, ... ... Goate AM, et al. Rarity of the Alzheimer disease-protective APP A673T variant in the United States. Jama Neurology. 72: 209-16. PMID 25531812 DOI: 10.1001/Jamaneurol.2014.2157 |
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Karch CM, Goate AM. Alzheimer's disease risk genes and mechanisms of disease pathogenesis. Biological Psychiatry. 77: 43-51. PMID 24951455 DOI: 10.1016/J.Biopsych.2014.05.006 |
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Wetherill L, Agrawal A, Kapoor M, Bertelsen S, Bierut LJ, Brooks A, Dick D, Hesselbrock M, Hesselbrock V, Koller DL, Le N, Nurnberger JI, Salvatore JE, Schuckit M, Tischfield JA, ... ... Goate AM, et al. Association of substance dependence phenotypes in the COGA sample. Addiction Biology. 20: 617-27. PMID 24832863 DOI: 10.1111/Adb.12153 |
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Karch C, Hsu S, Ezerskiy L, Martinez R, Norton J, Cruchaga C, Goate AM. S2-02-04: Phospholipase D3 contributes to Alzheimer's disease risk via disruption in app trafficking and Aβ generation Alzheimer's & Dementia. 11: P163-P163. DOI: 10.1016/J.Jalz.2015.07.106 |
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Karch C, Martinez R, Hsu S, Ezerskiy L, Norton J, Goate A. O1-06-01: Modeling tauopathies in human pluripotent stem cells Alzheimer's & Dementia. 11: P138-P138. DOI: 10.1016/J.Jalz.2015.07.057 |
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Day GS, Lim TS, Hassenstab J, Grant EA, Goate A, Morris JC, Cairns NJ. Differentiating corticobasal degeneration and Alzheimer disease by longitudinal clinical and cognitive features Alzheimers & Dementia. 11: 525. DOI: 10.1016/J.Jalz.2015.06.646 |
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Del-Aguila JL, Gross AL, Sutti S, Sherva R, Mukherjee S, Crane PK, Goate A, Morris JC, Green RC, Cruchaga C. Identification of genetic variants associated with Alzheimer's disease: Progression rate Alzheimers & Dementia. 11: 487. DOI: 10.1016/J.Jalz.2015.06.552 |
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Tsuang D, Vardarajan BN, Bird TD, Boeve B, Schaid D, Taner N, Allen M, Barral S, Bennett DA, Cruchaga C, Goate A, Graff-Radford N, Faber K, Farlow MR, Foroud TM, et al. MAPT haplotypes modify the association between head injury and risk of Alzheimer’s disease Alzheimers & Dementia. 11: 361. DOI: 10.1016/J.Jalz.2015.06.256 |
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Kobolt D, Lord J, Fernandez V, del-Aguila J, Kang CJ, Saef B, Wilson R, Goate A, Cruchaga C. P1-055: Exome-sequencing in a large dataset of late-onset families with Alzheimer's disease Alzheimer's & Dementia. 11: P359-P359. DOI: 10.1016/J.Jalz.2015.06.252 |
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Monsell SE, Mock C, Fardo DW, Bertelsen S, Cairns NJ, Roe CM, Morris JC, Goate A, Kukull W. Genetic differences between symptomatic and asymptomatic persons with Alzheimer's disease neuropathologic change Alzheimers & Dementia. 11: 767. DOI: 10.1016/J.Jalz.2015.06.1711 |
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Olfson E, Bloom J, Bertelsen S, Budde J, Hesselbrock V, Kramer J, Goate A, Bierut L. CYP2A6 metabolism in the development of nicotine dependence in adolescents and young adults Drug and Alcohol Dependence. 146. DOI: 10.1016/J.Drugalcdep.2014.09.524 |
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Ghani M, Reitz C, Cheng R, Vardarajan BN, Jun G, Sato C, Naj A, Rajbhandary R, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, ... ... Goate AM, et al. Association of long runs of homozygosity with Alzheimer disease among African American individuals Jama Neurology. 72: 1313-1323. DOI: 10.1001/jamaneurol.2015.1700z |
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Wetzel-Smith MK, Hunkapiller J, Bhangale TR, Srinivasan K, Maloney JA, Atwal JK, Sa SM, Yaylaoglu MB, Foreman O, Ortmann W, Rathore N, Hansen DV, Tessier-Lavigne M, Mayeux R, ... ... Goate A, et al. A rare mutation in UNC5C predisposes to late-onset Alzheimer's disease and increases neuronal cell death. Nature Medicine. 20: 1452-7. PMID 25419706 DOI: 10.1038/Nm.3736 |
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Izzo NJ, Xu J, Zeng C, Kirk MJ, Mozzoni K, Silky C, Rehak C, Yurko R, Look G, Rishton G, Safferstein H, Cruchaga C, Goate A, Cahill MA, Arancio O, et al. Alzheimer's therapeutics targeting amyloid beta 1-42 oligomers II: Sigma-2/PGRMC1 receptors mediate Abeta 42 oligomer binding and synaptotoxicity. Plos One. 9: e111899. PMID 25390692 DOI: 10.1371/Journal.Pone.0111899 |
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Kauwe JS, Bailey MH, Ridge PG, Perry R, Wadsworth ME, Hoyt KL, Staley LA, Karch CM, Harari O, Cruchaga C, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, ... ... Goate AM, et al. Genome-wide association study of CSF levels of 59 alzheimer's disease candidate proteins: significant associations with proteins involved in amyloid processing and inflammation. Plos Genetics. 10: e1004758. PMID 25340798 DOI: 10.1371/Journal.Pgen.1004758 |
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Ringman JM, Goate A, Masters CL, Cairns NJ, Danek A, Graff-Radford N, Ghetti B, Morris JC. Genetic heterogeneity in Alzheimer disease and implications for treatment strategies. Current Neurology and Neuroscience Reports. 14: 499. PMID 25217249 DOI: 10.1007/S11910-014-0499-8 |
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Naj AC, Jun G, Reitz C, Kunkle BW, Perry W, Park YS, Beecham GW, Rajbhandary RA, Hamilton-Nelson KL, Wang LS, Kauwe JS, Huentelman MJ, Myers AJ, Bird TD, Boeve BF, ... ... Goate AM, et al. Effects of multiple genetic loci on age at onset in late-onset Alzheimer disease: a genome-wide association study. Jama Neurology. 71: 1394-404. PMID 25199842 DOI: 10.1001/Jamaneurol.2014.1491 |
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Logue MW, Schu M, Vardarajan BN, Farrell J, Bennett DA, Buxbaum JD, Byrd GS, Ertekin-Taner N, Evans D, Foroud T, Goate A, Graff-Radford NR, Kamboh MI, Kukull WA, Manly JJ, et al. Two rare AKAP9 variants are associated with Alzheimer's disease in African Americans. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 609-618.e11. PMID 25172201 DOI: 10.1016/J.Jalz.2014.06.010 |
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Thomas JB, Brier MR, Bateman RJ, Snyder AZ, Benzinger TL, Xiong C, Raichle M, Holtzman DM, Sperling RA, Mayeux R, Ghetti B, Ringman JM, Salloway S, McDade E, Rossor MN, ... ... Goate AM, et al. Functional connectivity in autosomal dominant and late-onset Alzheimer disease. Jama Neurology. 71: 1111-22. PMID 25069482 DOI: 10.1001/Jamaneurol.2014.1654 |
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Nalls MA, Pankratz N, Lill CM, Do CB, Hernandez DG, Saad M, DeStefano AL, Kara E, Bras J, Sharma M, Schulte C, Keller MF, Arepalli S, Letson C, Edsall C, ... ... Goate A, et al. Large-scale meta-analysis of genome-wide association data identifies six new risk loci for Parkinson's disease. Nature Genetics. 46: 989-93. PMID 25064009 DOI: 10.1038/Ng.3043 |
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Ramirez A, van der Flier WM, Herold C, Ramonet D, Heilmann S, Lewczuk P, Popp J, Lacour A, Drichel D, Louwersheimer E, Kummer MP, Cruchaga C, Hoffmann P, Teunissen C, Holstege H, ... ... Goate A, et al. SUCLG2 identified as both a determinator of CSF Aβ1-42 levels and an attenuator of cognitive decline in Alzheimer's disease. Human Molecular Genetics. 23: 6644-58. PMID 25027320 DOI: 10.1093/Hmg/Ddu372 |
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Karch CM, Cruchaga C, Goate AM. Alzheimer's disease genetics: from the bench to the clinic. Neuron. 83: 11-26. PMID 24991952 DOI: 10.1016/J.Neuron.2014.05.041 |
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Kapoor M, Wang JC, Wetherill L, Le N, Bertelsen S, Hinrichs AL, Budde J, Agrawal A, Almasy L, Bucholz K, Dick DM, Harari O, Xiaoling X, Hesselbrock V, Kramer J, ... ... Goate A, et al. Genome-wide survival analysis of age at onset of alcohol dependence in extended high-risk COGA families. Drug and Alcohol Dependence. 142: 56-62. PMID 24962325 DOI: 10.1016/J.Drugalcdep.2014.05.023 |
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Ryman DC, Acosta-Baena N, Aisen PS, Bird T, Danek A, Fox NC, Goate A, Frommelt P, Ghetti B, Langbaum JB, Lopera F, Martins R, Masters CL, Mayeux RP, McDade E, et al. Symptom onset in autosomal dominant Alzheimer disease: a systematic review and meta-analysis. Neurology. 83: 253-60. PMID 24928124 DOI: 10.1212/Wnl.0000000000000596 |
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Escott-Price V, Bellenguez C, Wang LS, Choi SH, Harold D, Jones L, Holmans P, Gerrish A, Vedernikov A, Richards A, DeStefano AL, Lambert JC, Ibrahim-Verbaas CA, Naj AC, Sims R, ... ... Goate AM, et al. Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease. Plos One. 9: e94661. PMID 24922517 DOI: 10.1371/Journal.Pone.0094661 |
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Jin SC, Benitez BA, Karch CM, Cooper B, Skorupa T, Carrell D, Norton JB, Hsu S, Harari O, Cai Y, Bertelsen S, Goate AM, Cruchaga C. Coding variants in TREM2 increase risk for Alzheimer's disease. Human Molecular Genetics. 23: 5838-46. PMID 24899047 DOI: 10.1093/Hmg/Ddu277 |
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Haller G, Li P, Esch C, Hsu S, Goate AM, Steinbach JH. Functional characterization improves associations between rare non-synonymous variants in CHRNB4 and smoking behavior. Plos One. 9: e96753. PMID 24804708 DOI: 10.1371/Journal.Pone.0096753 |
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Fagan AM, Xiong C, Jasielec MS, Bateman RJ, Goate AM, Benzinger TL, Ghetti B, Martins RN, Masters CL, Mayeux R, Ringman JM, Rossor MN, Salloway S, Schofield PR, Sperling RA, et al. Longitudinal change in CSF biomarkers in autosomal-dominant Alzheimer's disease. Science Translational Medicine. 6: 226ra30. PMID 24598588 DOI: 10.1126/Scitranslmed.3007901 |
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Harari O, Cruchaga C, Kauwe JS, Ainscough BJ, Bales K, Pickering EH, Bertelsen S, Fagan AM, Holtzman DM, Morris JC, Goate AM. Phosphorylated tau-Aβ42 ratio as a continuous trait for biomarker discovery for early-stage Alzheimer's disease in multiplex immunoassay panels of cerebrospinal fluid. Biological Psychiatry. 75: 723-31. PMID 24548642 DOI: 10.1016/J.Biopsych.2013.11.032 |
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Cady J, Koval ED, Benitez BA, Zaidman C, Jockel-Balsarotti J, Allred P, Baloh RH, Ravits J, Simpson E, Appel SH, Pestronk A, Goate AM, Miller TM, Cruchaga C, Harms MB. TREM2 variant p.R47H as a risk factor for sporadic amyotrophic lateral sclerosis. Jama Neurology. 71: 449-53. PMID 24535663 DOI: 10.1001/Jamaneurol.2013.6237 |
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Benitez BA, Jin SC, Guerreiro R, Graham R, Lord J, Harold D, Sims R, Lambert JC, Gibbs JR, Bras J, Sassi C, Harari O, Bertelsen S, Lupton MK, Powell J, ... ... Goate AM, et al. Missense variant in TREML2 protects against Alzheimer's disease. Neurobiology of Aging. 35: 1510.e19-26. PMID 24439484 DOI: 10.1016/J.Neurobiolaging.2013.12.010 |
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| 2014 |
Vardarajan BN, Faber KM, Bird TD, Bennett DA, Rosenberg R, Boeve BF, Graff-Radford NR, Goate AM, Farlow M, Sweet RA, Lantigua R, Medrano MZ, Ottman R, Schaid DJ, Foroud TM, et al. Age-specific incidence rates for dementia and Alzheimer disease in NIA-LOAD/NCRAD and EFIGA families: National Institute on Aging Genetics Initiative for Late-Onset Alzheimer Disease/National Cell Repository for Alzheimer Disease (NIA-LOAD/NCRAD) and Estudio Familiar de Influencia Genetica en Alzheimer (EFIGA). Jama Neurology. 71: 315-23. PMID 24425039 DOI: 10.1001/Jamaneurol.2013.5570 |
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Ting SK, Benzinger T, Kepe V, Fagan A, Coppola G, Porter V, Hecimovic S, Chakraverty S, Alvarez-Retuerto AI, Goate A, Ringman JM. A novel PSEN1 mutation (I238M) associated with early-onset Alzheimer's disease in an African-American woman. Journal of Alzheimer's Disease : Jad. 40: 271-5. PMID 24413619 DOI: 10.3233/Jad-131844 |
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Cruchaga C, Karch CM, Jin SC, Benitez BA, Cai Y, Guerreiro R, Harari O, Norton J, Budde J, Bertelsen S, Jeng AT, Cooper B, Skorupa T, Carrell D, Levitch D, ... ... Goate AM, et al. Rare coding variants in the phospholipase D3 gene confer risk for Alzheimer's disease. Nature. 505: 550-4. PMID 24336208 DOI: 10.1038/Nature12825 |
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Bloom AJ, Baker TB, Chen LS, Breslau N, Hatsukami D, Bierut LJ, Goate A. Variants in two adjacent genes, EGLN2 and CYP2A6, influence smoking behavior related to disease risk via different mechanisms. Human Molecular Genetics. 23: 555-61. PMID 24045616 DOI: 10.1093/Hmg/Ddt432 |
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Wetherill L, Kapoor M, Agrawal A, Bucholz K, Koller D, Bertelsen SE, Le N, Wang JC, Almasy L, Hesselbrock V, Kramer J, Nurnberger JI, Schuckit M, Tischfield JA, Xuei X, ... ... Goate AM, et al. Family-based association analysis of alcohol dependence criteria and severity. Alcoholism, Clinical and Experimental Research. 38: 354-66. PMID 24015780 DOI: 10.1111/Acer.12251 |
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| 2014 |
Peterson D, Munger C, Crowley J, Corcoran C, Cruchaga C, Goate AM, Norton MC, Green RC, Munger RG, Breitner JC, Welsh-Bohmer KA, Lyketsos C, Tschanz J, Kauwe JS. Variants in PPP3R1 and MAPT are associated with more rapid functional decline in Alzheimer's disease: the Cache County Dementia Progression Study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 366-71. PMID 23727081 DOI: 10.1016/J.Jalz.2013.02.010 |
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Dick DM, Cho SB, Latendresse SJ, Aliev F, Nurnberger JI, Edenberg HJ, Schuckit M, Hesselbrock VM, Porjesz B, Bucholz K, Wang JC, Goate A, Kramer JR, Kuperman S. Genetic influences on alcohol use across stages of development: GABRA2 and longitudinal trajectories of drunkenness from adolescence to young adulthood. Addiction Biology. 19: 1055-64. PMID 23692184 DOI: 10.1111/Adb.12066 |
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| 2014 |
Yan J, Aliev F, Webb BT, Kendler KS, Williamson VS, Edenberg HJ, Agrawal A, Kos MZ, Almasy L, Nurnberger JI, Schuckit MA, Kramer JR, Rice JP, Kuperman S, Goate AM, et al. Using genetic information from candidate gene and genome-wide association studies in risk prediction for alcohol dependence. Addiction Biology. 19: 708-21. PMID 23362995 DOI: 10.1111/Adb.12035 |
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Goate AM, Karch C, Hsu S, Jeng AT, Sears R, Cruchaga C. O2-12-04: ALZHEIMER'S DISEASE RISK VARIANTS IN PHOSPHOLIPASE D3 ALTER APP METABOLISM BY GAMMA-DEPENDENT AND GAMMA-INDEPENDENT MECHANISMS Alzheimer's & Dementia. 10: P192-P192. DOI: 10.1016/J.Jalz.2014.04.225 |
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| 2014 |
Cruchaga C, Jin SC, Benitez BA, Karch C, Goate A. O1-04-05: NOVEL CODING VARIANTS IN TREM2 INCREASE RISK FOR ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P136-P136. DOI: 10.1016/J.Jalz.2014.04.078 |
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| 2014 |
Cruchaga C, Brkanac Z, Jin SC, Benitez BA, Rehker J, Ridge P, Kauwe J, Hardy J, Bras J, Guerreiro R, Singleton A, Goate A. O1-04-02: EXOME-SEQUENCING IN LATE-ONSET FAMILIES IDENTIFIED ADDITIONAL CANDIDATES GENES FOR ALZHEIMER'S DISEASE Alzheimer's & Dementia. 10: P135-P135. DOI: 10.1016/J.Jalz.2014.04.075 |
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Wang JC, Spiegel N, Bertelsen S, Le N, McKenna N, Budde JP, Harari O, Kapoor M, Brooks A, Hancock D, Tischfield J, Foroud T, Bierut LJ, Steinbach JH, Edenberg HJ, ... ... Goate AM, et al. Cis-regulatory variants affect CHRNA5 mRNA expression in populations of African and European ancestry. Plos One. 8: e80204. PMID 24303001 DOI: 10.1371/Journal.Pone.0080204 |
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Benzinger TL, Blazey T, Jack CR, Koeppe RA, Su Y, Xiong C, Raichle ME, Snyder AZ, Ances BM, Bateman RJ, Cairns NJ, Fagan AM, Goate A, Marcus DS, Aisen PS, et al. Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 110: E4502-9. PMID 24194552 DOI: 10.1073/Pnas.1317918110 |
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Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B, Russo G, Thorton-Wells TA, Jones N, Smith AV, Chouraki V, ... ... Goate AM, et al. Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease. Nature Genetics. 45: 1452-8. PMID 24162737 DOI: 10.1038/Ng.2802 |
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Honea RA, Cruchaga C, Perea RD, Saykin AJ, Burns JM, Weinberger DR, Goate AM. Characterizing the role of brain derived neurotrophic factor genetic variation in Alzheimer's disease neurodegeneration. Plos One. 8: e76001. PMID 24086677 DOI: 10.1371/Journal.Pone.0076001 |
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Mills SM, Mallmann J, Santacruz AM, Fuqua A, Carril M, Aisen PS, Althage MC, Belyew S, Benzinger TL, Brooks WS, Buckles VD, Cairns NJ, Clifford D, Danek A, Fagan AM, ... ... Goate AM, et al. Preclinical trials in autosomal dominant AD: implementation of the DIAN-TU trial. Revue Neurologique. 169: 737-43. PMID 24016464 DOI: 10.1016/J.Neurol.2013.07.017 |
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Benitez BA, Karch CM, Cai Y, Jin SC, Cooper B, Carrell D, Bertelsen S, Chibnik L, Schneider JA, Bennett DA, Fagan AM, Holtzman D, Morris JC, ... Goate AM, et al. The PSEN1, p.E318G variant increases the risk of Alzheimer's disease in APOE-ε4 carriers. Plos Genetics. 9: e1003685. PMID 23990795 DOI: 10.1371/Journal.Pgen.1003685 |
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Frost SM, Kanagasingam Y, Sohrabi HR, Taddei K, Bateman R, Morris J, Benzinger T, Goate A, Masters CL, Martins RN. Pupil response biomarkers distinguish amyloid precursor protein mutation carriers from non-carriers. Current Alzheimer Research. 10: 790-6. PMID 23919771 DOI: 10.2174/15672050113109990154 |
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Campbell MC, Markham J, Flores H, Hartlein JM, Goate AM, Cairns NJ, Videen TO, Perlmutter JS. Principal component analysis of PiB distribution in Parkinson and Alzheimer diseases. Neurology. 81: 520-7. PMID 23825179 DOI: 10.1212/Wnl.0B013E31829E6F94 |
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Potter R, Patterson BW, Elbert DL, Ovod V, Kasten T, Sigurdson W, Mawuenyega K, Blazey T, Goate A, Chott R, Yarasheski KE, Holtzman DM, Morris JC, Benzinger TL, Bateman RJ. Increased in vivo amyloid-β42 production, exchange, and loss in presenilin mutation carriers. Science Translational Medicine. 5: 189ra77. PMID 23761040 DOI: 10.1126/Scitranslmed.3005615 |
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Karch CM, Jeng AT, Skorupa T, Cruchaga C, Goate AM. Novel progranulin variants do not disrupt progranulin secretion and cleavage. Neurobiology of Aging. 34: 2538-40. PMID 23759146 DOI: 10.1016/J.Neurobiolaging.2013.05.004 |
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Kapoor M, Wang JC, Wetherill L, Le N, Bertelsen S, Hinrichs AL, Budde J, Agrawal A, Bucholz K, Dick D, Harari O, Hesselbrock V, Kramer J, Nurnberger JI, Rice J, ... ... Goate A, et al. A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks. Human Genetics. 132: 1141-51. PMID 23743675 DOI: 10.1007/S00439-013-1318-Z |
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Zhang Z, Wang JC, Howells W, Lin P, Agrawal A, Edenberg HJ, Tischfield JA, Schuckit MA, Bierut LJ, Goate A, Rice JP. Dosage transmission disequilibrium test (dTDT) for linkage and association detection. Plos One. 8: e63526. PMID 23691058 DOI: 10.1371/Journal.Pone.0063526 |
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Kos MZ, Yan J, Dick DM, Agrawal A, Bucholz KK, Rice JP, Johnson EO, Schuckit M, Kuperman S, Kramer J, Goate AM, Tischfield JA, Foroud T, Nurnberger J, Hesselbrock V, et al. Common biological networks underlie genetic risk for alcoholism in African- and European-American populations. Genes, Brain, and Behavior. 12: 532-42. PMID 23607416 DOI: 10.1111/Gbb.12043 |
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Harms MB, Cady J, Zaidman C, Cooper P, Bali T, Allred P, Cruchaga C, Baughn M, Libby RT, Pestronk A, Goate A, Ravits J, Baloh RH. Lack of C9ORF72 coding mutations supports a gain of function for repeat expansions in amyotrophic lateral sclerosis. Neurobiology of Aging. 34: 2234.e13-9. PMID 23597494 DOI: 10.1016/J.Neurobiolaging.2013.03.006 |
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Harms M, Benitez BA, Cairns N, Cooper B, Cooper P, Mayo K, Carrell D, Faber K, Williamson J, Bird T, Diaz-Arrastia R, Foroud TM, Boeve BF, Graff-Radford NR, Mayeux R, ... ... Goate AM, et al. C9orf72 hexanucleotide repeat expansions in clinical Alzheimer disease. Jama Neurology. 70: 736-41. PMID 23588422 DOI: 10.1001/2013.Jamaneurol.537 |
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Reitz C, Jun G, Naj A, Rajbhandary R, Vardarajan BN, Wang LS, Valladares O, Lin CF, Larson EB, Graff-Radford NR, Evans D, De Jager PL, Crane PK, Buxbaum JD, Murrell JR, ... ... Goate AM, et al. Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E ϵ4,and the risk of late-onset Alzheimer disease in African Americans. Jama. 309: 1483-92. PMID 23571587 DOI: 10.1001/Jama.2013.2973 |
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Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, ... ... Goate AM, et al. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 78: 256-68. PMID 23562540 DOI: 10.1016/J.Neuron.2013.02.026 |
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Bloom AJ, Harari O, Martinez M, Zhang X, McDonald SA, Murphy SE, Goate A. A compensatory effect upon splicing results in normal function of the CYP2A6*14 allele. Pharmacogenetics and Genomics. 23: 107-16. PMID 23292114 DOI: 10.1097/Fpc.0B013E32835Caf7D |
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Guerreiro R, Wojtas A, Bras J, Carrasquillo M, Rogaeva E, Majounie E, Cruchaga C, Sassi C, Kauwe JS, Younkin S, Hazrati L, Collinge J, Pocock J, Lashley T, Williams J, ... ... Goate A, et al. TREM2 variants in Alzheimer's disease. The New England Journal of Medicine. 368: 117-27. PMID 23150934 DOI: 10.1056/Nejmoa1211851 |
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Harms MB, Neumann D, Benitez BA, Cooper B, Carrell D, Racette BA, Perlmutter JS, Goate A, Cruchaga C. Parkinson disease is not associated with C9ORF72 repeat expansions. Neurobiology of Aging. 34: 1519.e1-2. PMID 23116878 DOI: 10.1016/J.Neurobiolaging.2012.10.001 |
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Wang JC, Foroud T, Hinrichs AL, Le NX, Bertelsen S, Budde JP, Harari O, Koller DL, Wetherill L, Agrawal A, Almasy L, Brooks AI, Bucholz K, Dick D, Hesselbrock V, ... ... Goate AM, et al. A genome-wide association study of alcohol-dependence symptom counts in extended pedigrees identifies C15orf53. Molecular Psychiatry. 18: 1218-24. PMID 23089632 DOI: 10.1038/Mp.2012.143 |
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Karch CM, Jeng AT, Goate AM. Calcium phosphatase calcineurin influences tau metabolism. Neurobiology of Aging. 34: 374-86. PMID 22676853 DOI: 10.1016/J.Neurobiolaging.2012.05.003 |
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Harari O, Wang J, Bucholz K, Edenberg HJ, Heath A, Martin NG, Pergadia ML, Montgomery G, Schrage A, Bierut LJ, Madden PF, Goate AM. Correction: Pathway Analysis of Smoking Quantity in Multiple GWAS Identifies Cholinergic and Sensory Pathways Plos One. 8. DOI: 10.1371/Annotation/21033005-E120-4364-8024-C6534B4108F6 |
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Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Goate AM, et al. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Nature Genetics. 45: 712-712. DOI: 10.1038/Ng0613-712A |
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Honea R, Cruchaga C, Perea R, Swerdlow R, Weinberger D, Saykin A, Goate A. P1-281: Role of genetic variation on longitudinal imaging measures of Alzheimer's disease in the ADNI Cohort Alzheimer's & Dementia. 9: P257-P257. DOI: 10.1016/J.Jalz.2013.05.506 |
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Thomas J, Brier M, Bateman R, Snyder A, Benzinger T, Xiong C, Raichle M, Sperling R, Mayeux R, Ghetti B, Ringman J, Salloway S, McDade E, Rossor M, Schofield P, ... ... Goate A, et al. IC-P-184: Resting state functional connectivity in autosomal dominant and sporadic Alzheimer's disease Alzheimer's & Dementia. 9: P105-P105. DOI: 10.1016/J.Jalz.2013.05.181 |
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Cruchaga C, Harari O, Kauwe J, Bales K, Pickering EH, Bertelsen S, Fagan A, Holtzman D, Morris J, Goate A. P4-002: Cerebrospinal heart fatty-acid-binding protein as a biomarker for Alzheimer's disease Alzheimer's & Dementia. 9: P705-P705. DOI: 10.1016/J.Jalz.2013.05.1390 |
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Vardarajan B, Bennett D, Bird T, Boeve B, Farlow M, Foroud T, Goate A, Graff-Radford N, Ottman R, Rosenberg RN, Schaid D, Sweet R, Tsuang D, Bennett J, Davis B, et al. Age-specific incidence rates of Alzheimer's disease in family members participating in the NIA-LOAD genetics study Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.1266 |
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Blazey T, Jack C, Kantarci K, Preboske G, Ringman J, Brickman A, Raichle M, Hornbeck R, Saykin A, Salloway S, McDade E, Rossor M, Fox N, Thompson P, Correia S, ... ... Goate A, et al. Prevalence and growth of cerebral microhemorrhages in autosomal dominant Alzheimer's disease Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.05.100 |
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Chhatwal J, Schultz A, Johnson K, Benzinger T, Jack C, Ances B, Sullivan C, Salloway S, Ringman J, Koeppe R, Marcus D, Thompson P, Saykin A, Correia S, Schofield P, ... ... Goate A, et al. IC-P-082: Disrupted functional connectivity in autosomal dominant Alzheimer's disease demonstrates network specificity and precedes brain volume loss: Findings from DIAN Alzheimer's & Dementia. 9: P49-P50. DOI: 10.1016/J.Jalz.2013.05.079 |
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Cash D, Ridgway G, Modat M, Ryan N, Kinnunen K, Cardoso J, Benzinger T, Jack CR, Raichle M, Marcus D, Ringman J, Thompson P, Ghetti B, Salloway S, Sperling R, ... ... Goate A, et al. Dissociating volume and intensity differences in familial Alzheimer's disease Alzheimers & Dementia. 9: 603. DOI: 10.1016/J.Jalz.2013.05.075 |
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Chhatwal J, Schultz A, Johnson K, Benzinger T, Jack C, Ances B, Sullivan C, Salloway S, Ringman J, Koeppe R, Marcus D, Thompson P, Saykin A, Correia S, Schofield P, ... ... Goate A, et al. O4-03-03: Disrupted functional connectivity in autosomal dominant Alzheimer's disease demonstrates network specificity and precedes brain volume loss: Findings from the Dominantly Inherited Alzheimer Network Alzheimer's & Dementia. 9: P684-P685. DOI: 10.1016/J.Jalz.2013.04.348 |
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Benitez B, Karch C, Jin SC, Carrel D, Cooper B, Bertelsen S, Morris J, Holtzman D, Goate A, Cruchaga C. Rare variants in APP and PSEN1 genes associated with extreme levels of beta-amyloid 42 and tau protein in cerebrospinal fluid Alzheimers & Dementia. 9: 680. DOI: 10.1016/J.Jalz.2013.04.338 |
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Kauwe J, Bailey M, Ridge P, Cruchaga C, Foutz S, Perry R, Harari O, Bertelsen S, Ainscough B, Bales K, Pickering EH, Fagan A, Holtzman D, Morris J, Goate A. O4-01-01: Association of genetic variants with cerebrospinal fluid protein levels of ACE, MMP3 and other proteins and risk for Alzheimer's disease Alzheimer's & Dementia. 9: P677-P678. DOI: 10.1016/J.Jalz.2013.04.334 |
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Hunkapiller J, Wetzel M, Bhangale T, Maloney J, Atwal J, Ortmann W, Tessier-Lavigne M, Goate A, Behrens T, Cruchaga C, Watts R, Graham R. A rare coding variant alters UNC5C function and predisposes to Alzheimer's disease Alzheimers & Dementia. 9: 311. DOI: 10.1016/J.Jalz.2013.04.125 |
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Kinnunen K, Ryan N, Cash D, Leite AB, Finnegan S, Cardoso M, Leung K, Modat M, Benzinger T, Jack C, Marcus D, Raichle M, Thompson P, Ringman J, Ghetti B, ... ... Goate A, et al. Are early atrophy patterns in autosomal dominant familial Alzheimer's disease gene-dependent? Alzheimers & Dementia. 9. DOI: 10.1016/J.Jalz.2013.04.017 |
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Harari O, Wang JC, Bucholz K, Edenberg HJ, Heath A, Martin NG, Pergadia ML, Montgomery G, Schrage A, Bierut LJ, Madden PF, Goate AM. Pathway analysis of smoking quantity in multiple GWAS identifies cholinergic and sensory pathways. Plos One. 7: e50913. PMID 23227220 DOI: 10.1371/Journal.Pone.0050913 |
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Karch CM, Jeng AT, Nowotny P, Cady J, Cruchaga C, Goate AM. Expression of novel Alzheimer's disease risk genes in control and Alzheimer's disease brains. Plos One. 7: e50976. PMID 23226438 DOI: 10.1371/Journal.Pone.0050976 |
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Morris JC, Aisen PS, Bateman RJ, Benzinger TL, Cairns NJ, Fagan AM, Ghetti B, Goate AM, Holtzman DM, Klunk WE, McDade E, Marcus DS, Martins RN, Masters CL, Mayeux R, et al. Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network. Clinical Investigation. 2: 975-984. PMID 23139856 DOI: 10.4155/Cli.12.93 |
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Karch CM, Jeng AT, Goate AM. Extracellular Tau levels are influenced by variability in Tau that is associated with tauopathies. The Journal of Biological Chemistry. 287: 42751-62. PMID 23105105 DOI: 10.1074/Jbc.M112.380642 |
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Jin SC, Pastor P, Cooper B, Cervantes S, Benitez BA, Razquin C, Goate A, Cruchaga C. Pooled-DNA sequencing identifies novel causative variants in PSEN1, GRN and MAPT in a clinical early-onset and familial Alzheimer's disease Ibero-American cohort. Alzheimer's Research & Therapy. 4: 34. PMID 22906081 DOI: 10.1186/Alzrt137 |
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Cruchaga C, Kauwe JS, Nowotny P, Bales K, Pickering EH, Mayo K, Bertelsen S, Hinrichs A, Fagan AM, Holtzman DM, Morris JC, Goate AM. Cerebrospinal fluid APOE levels: an endophenotype for genetic studies for Alzheimer's disease. Human Molecular Genetics. 21: 4558-71. PMID 22821396 DOI: 10.1093/Hmg/Dds296 |
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Bateman RJ, Xiong C, Benzinger TL, Fagan AM, Goate A, Fox NC, Marcus DS, Cairns NJ, Xie X, Blazey TM, Holtzman DM, Santacruz A, Buckles V, Oliver A, Moulder K, et al. Clinical and biomarker changes in dominantly inherited Alzheimer's disease. The New England Journal of Medicine. 367: 795-804. PMID 22784036 DOI: 10.1056/Nejmoa1202753 |
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Allen M, Zou F, Chai HS, Younkin CS, Crook J, Pankratz VS, Carrasquillo MM, Rowley CN, Nair AA, Middha S, Maharjan S, Nguyen T, Ma L, Malphrus KG, Palusak R, ... ... Goate AM, et al. Novel late-onset Alzheimer disease loci variants associate with brain gene expression. Neurology. 79: 221-8. PMID 22722634 DOI: 10.1212/Wnl.0B013E3182605801 |
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Wang JC, Kapoor M, Goate AM. The genetics of substance dependence. Annual Review of Genomics and Human Genetics. 13: 241-61. PMID 22703173 DOI: 10.1146/Annurev-Genom-090711-163844 |
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Wildsmith KR, Basak JM, Patterson BW, Pyatkivskyy Y, Kim J, Yarasheski KE, Wang JX, Mawuenyega KG, Jiang H, Parsadanian M, Yoon H, Kasten T, Sigurdson WC, Xiong C, Goate A, et al. In vivo human apolipoprotein E isoform fractional turnover rates in the CNS. Plos One. 7: e38013. PMID 22675504 DOI: 10.1371/Journal.Pone.0038013 |
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Kang SJ, Rangaswamy M, Manz N, Wang JC, Wetherill L, Hinrichs T, Almasy L, Brooks A, Chorlian DB, Dick D, Hesselbrock V, Kramer J, Kuperman S, Nurnberger J, Rice J, ... ... Goate A, et al. Family-based genome-wide association study of frontal θ oscillations identifies potassium channel gene KCNJ6. Genes, Brain, and Behavior. 11: 712-9. PMID 22554406 DOI: 10.1111/J.1601-183X.2012.00803.X |
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Barral S, Bird T, Goate A, Farlow MR, Diaz-Arrastia R, Bennett DA, Graff-Radford N, Boeve BF, Sweet RA, Stern Y, Wilson RS, Foroud T, Ott J, Mayeux R. Genotype patterns at PICALM, CR1, BIN1, CLU, and APOE genes are associated with episodic memory. Neurology. 78: 1464-71. PMID 22539578 DOI: 10.1212/Wnl.0B013E3182553C48 |
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Chen LS, Saccone NL, Culverhouse RC, Bracci PM, Chen CH, Dueker N, Han Y, Huang H, Jin G, Kohno T, Ma JZ, Przybeck TR, Sanders AR, Smith JA, Sung YJ, ... ... Goate AM, et al. Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25. Genetic Epidemiology. 36: 340-51. PMID 22539395 DOI: 10.1002/Gepi.21627 |
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Rice JP, Hartz SM, Agrawal A, Almasy L, Bennett S, Breslau N, Bucholz KK, Doheny KF, Edenberg HJ, Goate AM, Hesselbrock V, Howells WB, Johnson EO, Kramer J, Krueger RF, et al. CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results. Addiction (Abingdon, England). 107: 2019-28. PMID 22524403 DOI: 10.1111/J.1360-0443.2012.03922.X |
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Bloom AJ, Harari O, Martinez M, Madden PA, Martin NG, Montgomery GW, Rice JP, Murphy SE, Bierut LJ, Goate A. Use of a predictive model derived from in vivo endophenotype measurements to demonstrate associations with a complex locus, CYP2A6. Human Molecular Genetics. 21: 3050-62. PMID 22451501 DOI: 10.1093/Hmg/Dds114 |
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Shi H, Belbin O, Medway C, Brown K, Kalsheker N, Carrasquillo M, Proitsi P, Powell J, Lovestone S, Goate A, Younkin S, Passmore P, Morgan K. Genetic variants influencing human aging from late-onset Alzheimer's disease (LOAD) genome-wide association studies (GWAS). Neurobiology of Aging. 33: 1849.e5-18. PMID 22445811 DOI: 10.1016/J.Neurobiolaging.2012.02.014 |
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Kapoor M, Wang JC, Bertelsen S, Bucholz K, Budde JP, Hinrichs A, Agrawal A, Brooks A, Chorlian D, Dick D, Hesselbrock V, Foroud T, Kramer J, Kuperman S, Manz N, ... ... Goate AM, et al. Variants located upstream of CHRNB4 on chromosome 15q25.1 are associated with age at onset of daily smoking and habitual smoking. Plos One. 7: e33513. PMID 22438940 DOI: 10.1371/Journal.Pone.0033513 |
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Derringer J, Krueger RF, Dick DM, Aliev F, Grucza RA, Saccone S, Agrawal A, Edenberg HJ, Goate AM, Hesselbrock VM, Kramer JR, Lin P, Neuman RJ, Nurnberger JI, Rice JP, et al. The aggregate effect of dopamine genes on dependence symptoms among cocaine users: cross-validation of a candidate system scoring approach. Behavior Genetics. 42: 626-35. PMID 22358648 DOI: 10.1007/S10519-012-9531-4 |
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Cruchaga C, Haller G, Chakraverty S, Mayo K, Vallania FL, Mitra RD, Faber K, Williamson J, Bird T, Diaz-Arrastia R, Foroud TM, Boeve BF, Graff-Radford NR, St Jean P, Lawson M, ... ... Goate AM, et al. Rare variants in APP, PSEN1 and PSEN2 increase risk for AD in late-onset Alzheimer's disease families. Plos One. 7: e31039. PMID 22312439 DOI: 10.1371/Journal.Pone.0031039 |
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Head D, Bugg JM, Goate AM, Fagan AM, Mintun MA, Benzinger T, Holtzman DM, Morris JC. Exercise Engagement as a Moderator of the Effects of APOE Genotype on Amyloid Deposition. Archives of Neurology. 69: 636-43. PMID 22232206 DOI: 10.1001/Archneurol.2011.845 |
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Goate A, Hardy J. Twenty years of Alzheimer's disease-causing mutations. Journal of Neurochemistry. 120: 3-8. PMID 22122678 DOI: 10.1111/J.1471-4159.2011.07575.X |
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Chen LS, Baker TB, Grucza R, Wang JC, Johnson EO, Breslau N, Hatsukami D, Smith SS, Saccone N, Saccone S, Rice JP, Goate AM, Bierut LJ. Dissection of the phenotypic and genotypic associations with nicotinic dependence. Nicotine & Tobacco Research : Official Journal of the Society For Research On Nicotine and Tobacco. 14: 425-33. PMID 22102629 DOI: 10.1093/Ntr/Ntr231 |
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Haller G, Druley T, Vallania FL, Mitra RD, Li P, Akk G, Steinbach JH, Breslau N, Johnson E, Hatsukami D, Stitzel J, Bierut LJ, Goate AM. Rare missense variants in CHRNB4 are associated with reduced risk of nicotine dependence. Human Molecular Genetics. 21: 647-55. PMID 22042774 DOI: 10.1093/Hmg/Ddr498 |
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Gerrish A, Russo G, Richards A, Moskvina V, Ivanov D, Harold D, Sims R, Abraham R, Hollingworth P, Chapman J, Hamshere M, Pahwa JS, Dowzell K, Williams A, Jones N, ... ... Goate AM, et al. The role of variation at AβPP, PSEN1, PSEN2, and MAPT in late onset Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 28: 377-87. PMID 22027014 DOI: 10.3233/Jad-2011-110824 |
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Bailey M, Maxwell T, Cruchaga C, Goate A, Kauwe J. P4-258: Genome-wide screen for variants that modify the known relationship between cerebrospinal fluid Beta-Amyloid 42 and ptau levels Alzheimer's & Dementia. 8: S749-S749. DOI: 10.1016/J.Jalz.2013.08.039 |
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| 2012 |
Becker J, Koeppe R, Benzinger T, Jack C, Marcus D, Raichle M, Thompson P, Saykin A, Correia S, Schofield P, Rowe C, Fox N, Brickman A, Ghetti B, Masters C, ... ... Goate A, et al. FDG metabolism in the DIAN study of autosomal dominant Alzheimer's disease Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.655 |
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| 2012 |
Chhatwal J, Schultz A, Johnson K, Benzinger T, Jack C, Salloway S, Ringman J, Koeppe R, Marcus D, Thompson P, Saykin A, Correia S, Schofield P, Rowe C, Fox N, ... ... Goate A, et al. O2-06-01: Disrupted functional connectivity in autosomal dominant Alzheimer's disease: Preliminary findings from the DIAN study Alzheimer's & Dementia. 8: P244-P245. DOI: 10.1016/J.Jalz.2012.05.654 |
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| 2012 |
Cruchaga C, Goate A, Thompson P, Kauwe J, Mayo K, Bertelsen S, Hinrichs T, Fagan A, Holtzman D. F2-02-04: Genome-wide association studies using cerebrospinal fluid biomarkers as an endophenotype for Alzheimer's disease Alzheimer's & Dementia. 8: P232-P233. DOI: 10.1016/J.Jalz.2012.05.615 |
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| 2012 |
Reitz C, Manly J, Hall KS, Evans D, Bennett D, Buxbaum J, Ertekin-Taner N, Fallin D, Kamboh I, Foroud T, Goate A, Farrer L, Pericak-Vance M, Haines J, Mayeux R, et al. CTNNA3, CAPRIN2 and SPG20 are significantly associated with Alzheimer's disease in preliminary analyses of a genome-wide association study in African-Americans Alzheimers & Dementia. 8: 100. DOI: 10.1016/J.Jalz.2012.05.251 |
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| 2012 |
Jin SC, Cooper B, Mayo K, Benitez B, Goate A, Cruchaga C. O5-03-02: Deep resequencing of GWAS loci associated with Alzheimer's disease Alzheimer's & Dementia. 8: P735-P735. DOI: 10.1016/J.Jalz.2012.05.1982 |
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| 2012 |
Benzinger T, Blazey T, Ances B, Raichle M, Ances B, Snyder A, Su Y, Marcus D, Ringman J, Thompson P, Ghetti B, Saykin A, Salloway S, Correia S, Johnson K, ... ... Goate A, et al. IC-P-128: Progressive white matter abnormalities in autosomal dominant Alzheimer's disease: Results of the DIAN study Alzheimer's & Dementia. 8: P68-P69. DOI: 10.1016/j.jalz.2012.05.1858 |
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| 2012 |
Jeng A, Karch C, Nowotny P, Cruchaga C, Goate A. P4-085: ABCA7 and MS4A6A expression are upregulated in Alzheimer's disease brains Alzheimer's & Dementia. 8: P663-P663. DOI: 10.1016/J.Jalz.2012.05.1787 |
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| 2012 |
Kinnunen K, Cash D, Leung K, Liang Y, Cardoso M, Modat M, Malone I, Benzinger T, Koeppe R, Jack C, Raichle M, Marcus D, Ringman J, Thompson P, Saykin A, ... ... Goate A, et al. Brain and hippocampal rates of atrophy in familial Alzheimer's disease mutation carriers: Preliminary findings from the DIAN study Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.172 |
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| 2012 |
Benzinger T, Blazey T, Koeppe R, Jack C, Raichle M, Su Y, Snyder A, Marcus D, Ringman J, Thompson P, Ghetti B, Saykin A, Salloway S, Correia S, Johnson K, ... ... Goate A, et al. Elevated PiB precedes dementia in autosomal dominant Alzheimer's disease: PiB, FDG and atrophy in the DIAN cohort Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.132 |
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| 2012 |
Kinnunen K, Cash D, Liang Y, Leung K, Cardoso M, Modat M, Malone I, Yeatman T, Nicholas J, Benzinger T, Koeppe R, Jack C, Raichle M, Marcus D, Ringman J, ... ... Goate A, et al. Cross-sectional cerebral volumetric differences and associations with estimated time to age-at-onset in familial Alzheimer's disease: Findings from the DIAN study Alzheimers & Dementia. 8: 23. DOI: 10.1016/J.Jalz.2012.05.064 |
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| 2012 |
Cash D, Ridgway G, Ryan N, Kinnunen K, Yeatman T, Malone I, Benzinger T, Koeppe R, Jack C, Raichle M, Marcus D, Ringman J, Thompson P, Saykin A, Salloway S, ... ... Goate A, et al. A voxel-based morphometry study of volumetric MRI in familial Alzheimer’s disease Alzheimers & Dementia. 8. DOI: 10.1016/J.Jalz.2012.05.052 |
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| 2012 |
Bateman R, Benzinger T, Cairns N, Fagan A, Goate A, Marcus D, Storandt M, Xiong C, Buckles V, Holtzman D, Moulder K, Oliver A, Santacruz A, Fox N, Ghetti B, et al. Presymptomatic Alzheimer's disease in the Dominantly Inherited Alzheimer's Network (DIAN) Alzheimers & Dementia. 8: 4. DOI: 10.1016/J.Jalz.2012.05.015 |
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| 2011 |
Holtzman DM, Goate A, Kelly J, Sperling R. Mapping the road forward in Alzheimer's disease. Science Translational Medicine. 3: 114ps48. PMID 22190237 DOI: 10.1126/Scitranslmed.3003529 |
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Vlassenko AG, Mintun MA, Xiong C, Sheline YI, Goate AM, Benzinger TL, Morris JC. Amyloid-beta plaque growth in cognitively normal adults: longitudinal [11C]Pittsburgh compound B data. Annals of Neurology. 70: 857-61. PMID 22162065 DOI: 10.1002/Ana.22608 |
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Benitez BA, Alvarado D, Cai Y, Mayo K, Chakraverty S, Norton J, Morris JC, Sands MS, Goate A, Cruchaga C. Exome-sequencing confirms DNAJC5 mutations as cause of adult neuronal ceroid-lipofuscinosis. Plos One. 6: e26741. PMID 22073189 DOI: 10.1371/Journal.Pone.0026741 |
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Cruchaga C, Nowotny P, Kauwe JS, Ridge PG, Mayo K, Bertelsen S, Hinrichs A, Fagan AM, Holtzman DM, Morris JC, Goate AM. Association and expression analyses with single-nucleotide polymorphisms in TOMM40 in Alzheimer disease. Archives of Neurology. 68: 1013-9. PMID 21825236 DOI: 10.1001/Archneurol.2011.155 |
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Lin P, Hartz SM, Wang JC, Krueger RF, Foroud TM, Edenberg HJ, Nurnberger JI, Brooks AI, Tischfield JA, Almasy L, Webb BT, Hesselbrock VM, Porjesz B, Goate AM, Bierut LJ, et al. Copy number variation accuracy in genome-wide association studies. Human Heredity. 71: 141-7. PMID 21778733 DOI: 10.1159/000324683 |
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Castellano JM, Kim J, Stewart FR, Jiang H, DeMattos RB, Patterson BW, Fagan AM, Morris JC, Mawuenyega KG, Cruchaga C, Goate AM, Bales KR, Paul SM, Bateman RJ, Holtzman DM. Human apoE isoforms differentially regulate brain amyloid-β peptide clearance. Science Translational Medicine. 3: 89ra57. PMID 21715678 DOI: 10.1126/Scitranslmed.3002156 |
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Hata S, Fujishige S, Araki Y, Taniguchi M, Urakami K, Peskind E, Akatsu H, Araseki M, Yamamoto K, Martins RN, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, ... ... Goate A, et al. Alternative processing of γ-secretase substrates in common forms of mild cognitive impairment and Alzheimer's disease: evidence for γ-secretase dysfunction. Annals of Neurology. 69: 1026-31. PMID 21681798 DOI: 10.1002/Ana.22343 |
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Agrawal A, Lynskey MT, Hinrichs A, Grucza R, Saccone SF, Krueger R, Neuman R, Howells W, Fisher S, Fox L, Cloninger R, Dick DM, Doheny KF, Edenberg HJ, Goate AM, et al. A genome-wide association study of DSM-IV cannabis dependence. Addiction Biology. 16: 514-8. PMID 21668797 DOI: 10.1111/J.1369-1600.2010.00255.X |
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Bloom J, Hinrichs AL, Wang JC, von Weymarn LB, Kharasch ED, Bierut LJ, Goate A, Murphy SE. The contribution of common CYP2A6 alleles to variation in nicotine metabolism among European-Americans. Pharmacogenetics and Genomics. 21: 403-16. PMID 21597399 DOI: 10.1097/Fpc.0B013E328346E8C0 |
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Heath AC, Whitfield JB, Martin NG, Pergadia ML, Goate AM, Lind PA, McEvoy BP, Schrage AJ, Grant JD, Chou YL, Zhu R, Henders AK, Medland SE, Gordon SD, Nelson EC, et al. A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications. Biological Psychiatry. 70: 513-8. PMID 21529783 DOI: 10.1016/J.Biopsych.2011.02.028 |
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| 2011 |
Holtzman DM, Morris JC, Goate AM. Alzheimer's disease: the challenge of the second century. Science Translational Medicine. 3: 77sr1. PMID 21471435 DOI: 10.1126/Scitranslmed.3002369 |
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Naj AC, Jun G, Beecham GW, Wang LS, Vardarajan BN, Buros J, Gallins PJ, Buxbaum JD, Jarvik GP, Crane PK, Larson EB, Bird TD, Boeve BF, Graff-Radford NR, De Jager PL, ... ... Goate AM, et al. Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease. Nature Genetics. 43: 436-41. PMID 21460841 DOI: 10.1038/Ng.801 |
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Hollingworth P, Harold D, Sims R, Gerrish A, Lambert JC, Carrasquillo MM, Abraham R, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Jones N, Stretton A, Thomas C, Richards A, ... ... Goate AM, et al. Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease. Nature Genetics. 43: 429-35. PMID 21460840 DOI: 10.1038/Ng.803 |
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Wijsman EM, Pankratz ND, Choi Y, Rothstein JH, Faber KM, Cheng R, Lee JH, Bird TD, Bennett DA, Diaz-Arrastia R, Goate AM, Farlow M, Ghetti B, Sweet RA, Foroud TM, et al. Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE. Plos Genetics. 7: e1001308. PMID 21379329 DOI: 10.1371/Journal.Pgen.1001308 |
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Kauwe JS, Cruchaga C, Karch CM, Sadler B, Lee M, Mayo K, Latu W, Su'a M, Fagan AM, Holtzman DM, Morris JC, Goate AM. Fine mapping of genetic variants in BIN1, CLU, CR1 and PICALM for association with cerebrospinal fluid biomarkers for Alzheimer's disease. Plos One. 6: e15918. PMID 21347408 DOI: 10.1371/Journal.Pone.0015918 |
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Cruchaga C, Graff C, Chiang HH, Wang J, Hinrichs AL, Spiegel N, Bertelsen S, Mayo K, Norton JB, Morris JC, Goate A. Association of TMEM106B gene polymorphism with age at onset in granulin mutation carriers and plasma granulin protein levels. Archives of Neurology. 68: 581-6. PMID 21220649 DOI: 10.1001/Archneurol.2010.350 |
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Zlojutro M, Manz N, Rangaswamy M, Xuei X, Flury-Wetherill L, Koller D, Bierut LJ, Goate A, Hesselbrock V, Kuperman S, Nurnberger J, Rice JP, Schuckit MA, Foroud T, Edenberg HJ, et al. Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 156: 44-58. PMID 21184583 DOI: 10.1002/Ajmg.B.31136 |
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Ringman JM, Gylys KH, Medina LD, Fox M, Kepe V, Flores DL, Apostolova LG, Barrio JR, Small G, Silverman DH, Siu E, Cederbaum S, Hecimovic S, Malnar M, Chakraverty S, ... Goate AM, et al. Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation. Neuroscience Letters. 487: 287-92. PMID 21094210 DOI: 10.1016/J.Neulet.2010.10.039 |
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Culverhouse RC, Saccone NL, Stitzel JA, Wang JC, Steinbach JH, Goate AM, Schwantes-An TH, Grucza RA, Stevens VL, Bierut LJ. Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence. Human Genetics. 129: 177-88. PMID 21079997 DOI: 10.1007/S00439-010-0911-7 |
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Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, ... ... Goate AM, et al. Correction: Genetic Evidence Implicates the Immune System and Cholesterol Metabolism in the Aetiology of Alzheimer's Disease Plos One. 6. DOI: 10.1371/annotation/a0bb886d-d345-4a20-a82e-adce9b047798 |
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Ringman JM, Gylys KH, Medina LD, Fox M, Kepe V, Flores DL, Apostolova LG, Barrio JR, Small G, Silverman DH, Siu E, Cederbaum S, Hecimovic S, Malnar M, Chakraverty S, ... Goate AM, et al. Corrigendum to " Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation" [Neurosci. Lett. 487 (2011) 287-292] Neuroscience Letters. 491: 163. DOI: 10.1016/J.Neulet.2011.01.021 |
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Kauwe J, Cruchaga C, McKean D, Bailey M, Patty D, Mayo K, Bertelsen S, Hinrichs A, Disease Genetics Consortium TA, Disease Neuroimaging Initiative TA, Fagan A, Holtzman D, Goate A. P4-453: Genome-wide association analysis using cerebrospinal fluid Abeta42 levels as an endophenotype for Alzheimer's disease Alzheimer's & Dementia. 7: e69-e70. DOI: 10.1016/J.Jalz.2011.09.148 |
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| 2011 |
Bailey M, Kauwe J, Cruchaga C, McKean D, Mayo K, Bertelsen S, Hinrichs T, Fagan A, Holtzman D, Goate A. P2-018: Association study of recently reported AD risk variants with cerebrospinal fluid AD biomarker levels Alzheimer's & Dementia. 7: S313-S313. DOI: 10.1016/J.Jalz.2011.05.908 |
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Taylor-Reinwald L, Grant E, Goate A, Morris J, Cairns N. Neuropathology of preclinical and incipient Alzheimer's dementia Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.881 |
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Head D, Bugg J, Goate A, Fagan A, Mintun M, Benzinger T, Holtzman D, Morris J. P1-377: Interactive effects of a sedentary lifestyle and the APOE e4 allele on amyloid deposition Alzheimer's & Dementia. 7: S233-S233. DOI: 10.1016/J.Jalz.2011.05.658 |
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Shi H, Medway C, Brown K, Kalsheker N, Goate A, Proitsi P, Powell J, Lovestone S, Carrasquillo M, Younkin S. Genetic Variants Influencing Human Longevity from Late-Onset Alzheimer’s Disease (LOAD) Genome-Wide Association Studies (GWAS) Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.542 |
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Peterson D, Kauwe J, Crowley J, Corcoran C, Cruchaga C, Goate A, Norton M, Green R, Munger R, Breitner J, Welsh-Bohmer K, Lyketsos K, Tschanz J. Support for Genetic Association Between Variants in PPP3R1 and MAPT and Rate of Progression of Alzheimer’s Disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.533 |
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| 2011 |
Cruchaga C, Nowotny P, Kauwe J, Mayo K, Bertelsen S, Hinrichs T, Fagan A, Holtzman D, Morris J, Goate A. P1-224: APOE Genotype is Associated with Cerebrospinal Fluid and Plasma APOE Levels But Not with APOE Expression Levels Alzheimer's & Dementia. 7: S182-S183. DOI: 10.1016/J.Jalz.2011.05.504 |
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| 2011 |
Cruchaga C, Kauwe J, Mayo K, Bertelsen S, Hinrichs T, Peskind E, Li G, Leverenz J, Galasko D, Fagan A, Holtzman D, Goate A. Genome-Wide Association Analyses Using Cerebrospinal Fluid Tau and Phospho-Tau Levels As An Endophenotype for Alzheimer’s Disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.503 |
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Benitez B, Cruchaga C, Kauwe J, Mayo K, Bertelsen S, Hinrichs A, Fagan A, Holtzman D, Goate A. Rare Genetic Variants in APP, PSEN1, PSEN2, GRN, APOE and MAPT Associated with CSF Aß and tau/ptau181 Levels in Patients with Late-Onset Alzheimer’s Disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.492 |
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Goate A, Holtzman D, Morris J, Cruchaga C, Nowotny P, Kauwe J, Fagan A, Mayo K, Bertelsen S, Hinrichs T. Association and expression analyses with SNPs in TOMM40 in Alzheimer's disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.227 |
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Kauwe J, Cruchaga C, McKean D, Bailey M, Patty D, Mayo K, Bertelsen S, Hinrichs A, Fagan A, Holtzman D, Goate A. Genome-wide association studies of CSF biomarkers Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.202 |
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| 2011 |
Karch C, Jeng A, Goate A. O4-04-07: Extracellular tau levels in cultured cells are influenced by genetic variants associated with dementia Alzheimer's & Dementia. 7: S690-S691. DOI: 10.1016/J.Jalz.2011.05.1995 |
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Fagan A, Xiong C, Bateman R, Goate A, Holtzman D, Ghetti B, Martins R, Masters C, Mayeux R, Ringman J, Rossor M, Salloway S, Schofield P, Sperling R, Morris J. Plasma and Cerebrospinal Fluid Markers in the DIAN Study of Autosomal-Dominant Alzheimer’s Disease Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1960 |
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| 2010 |
Sheline YI, Morris JC, Snyder AZ, Price JL, Yan Z, D'Angelo G, Liu C, Dixit S, Benzinger T, Fagan A, Goate A, Mintun MA. APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 17035-40. PMID 21159973 DOI: 10.1523/Jneurosci.3987-10.2010 |
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| 2010 |
Jones L, Holmans PA, Hamshere ML, Harold D, Moskvina V, Ivanov D, Pocklington A, Abraham R, Hollingworth P, Sims R, Gerrish A, Pahwa JS, Jones N, Stretton A, Morgan AR, ... ... Goate AM, et al. Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease. Plos One. 5: e13950. PMID 21085570 DOI: 10.1371/Journal.Pone.0013950 |
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| 2010 |
Cruchaga C, Kauwe JS, Mayo K, Spiegel N, Bertelsen S, Nowotny P, Shah AR, Abraham R, Hollingworth P, Harold D, Owen MM, Williams J, Lovestone S, Peskind ER, Li G, ... ... Goate AM, et al. SNPs associated with cerebrospinal fluid phospho-tau levels influence rate of decline in Alzheimer's disease. Plos Genetics. 6: e1001101. PMID 20862329 DOI: 10.1371/Journal.Pgen.1001101 |
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| 2010 |
Liang KY, Mintun MA, Fagan AM, Goate AM, Bugg JM, Holtzman DM, Morris JC, Head D. Exercise and Alzheimer's disease biomarkers in cognitively normal older adults. Annals of Neurology. 68: 311-8. PMID 20818789 DOI: 10.1002/Ana.22096 |
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| 2010 |
Jun G, Naj AC, Beecham GW, Wang LS, Buros J, Gallins PJ, Buxbaum JD, Ertekin-Taner N, Fallin MD, Friedland R, Inzelberg R, Kramer P, Rogaeva E, St George-Hyslop P, ... ... Goate AM, et al. Meta-analysis confirms CR1, CLU, and PICALM as alzheimer disease risk loci and reveals interactions with APOE genotypes. Archives of Neurology. 67: 1473-84. PMID 20697030 DOI: 10.1001/Archneurol.2010.201 |
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| 2010 |
Kauwe JS, Cruchaga C, Bertelsen S, Mayo K, Latu W, Nowotny P, Hinrichs AL, Fagan AM, Holtzman DM, Goate AM. Validating predicted biological effects of Alzheimer's disease associated SNPs using CSF biomarker levels. Journal of Alzheimer's Disease : Jad. 21: 833-42. PMID 20634593 DOI: 10.3233/Jad-2010-091711 |
0.798 |
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| 2010 |
Saccone NL, Schwantes-An TH, Wang JC, Grucza RA, Breslau N, Hatsukami D, Johnson EO, Rice JP, Goate AM, Bierut LJ. Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans. Genes, Brain, and Behavior. 9: 741-50. PMID 20584212 DOI: 10.1111/J.1601-183X.2010.00608.X |
0.322 |
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| 2010 |
Malnar M, Kosicek M, Mitterreiter S, Omerbasic D, Lichtenthaler SF, Goate A, Hecimovic S. Niemann-Pick type C cells show cholesterol dependent decrease of APP expression at the cell surface and its increased processing through the beta-secretase pathway. Biochimica Et Biophysica Acta. 1802: 682-91. PMID 20493254 DOI: 10.1016/J.Bbadis.2010.05.006 |
0.305 |
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| 2010 |
Dick DM, Meyers J, Aliev F, Nurnberger J, Kramer J, Kuperman S, Porjesz B, Tischfield J, Edenberg HJ, Foroud T, Schuckit M, Goate A, Hesselbrock V, Bierut L. Evidence for genes on chromosome 2 contributing to alcohol dependence with conduct disorder and suicide attempts American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 153: 1179-1188. PMID 20468071 DOI: 10.1002/Ajmg.B.31089 |
0.339 |
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| 2010 |
Goate A, Holtzman DM. Biomarkers will revolutionize the way we diagnose and treat Alzheimer's disease. Biomarkers in Medicine. 4: 1-2. PMID 20387300 DOI: 10.2217/Bmm.10.3 |
0.453 |
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| 2010 |
Chen AC, Manz N, Tang Y, Rangaswamy M, Almasy L, Kuperman S, Nurnberger J, O'Connor SJ, Edenberg HJ, Schuckit MA, Tischfield J, Foroud T, Bierut LJ, Rohrbaugh J, Rice JP, ... Goate A, et al. Single-nucleotide polymorphisms in corticotropin releasing hormone receptor 1 gene (CRHR1) are associated with quantitative trait of event-related potential and alcohol dependence. Alcoholism, Clinical and Experimental Research. 34: 988-96. PMID 20374216 DOI: 10.1111/J.1530-0277.2010.01173.X |
0.334 |
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| 2010 |
Edenberg HJ, Koller DL, Xuei X, Wetherill L, McClintick JN, Almasy L, Bierut LJ, Bucholz KK, Goate A, Aliev F, Dick D, Hesselbrock V, Hinrichs A, Kramer J, Kuperman S, et al. Genome-wide association study of alcohol dependence implicates a region on chromosome 11. Alcoholism, Clinical and Experimental Research. 34: 840-52. PMID 20201924 DOI: 10.1111/J.1530-0277.2010.01156.X |
0.354 |
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| 2010 |
Morris JC, Roe CM, Xiong C, Fagan AM, Goate AM, Holtzman DM, Mintun MA. APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging. Annals of Neurology. 67: 122-31. PMID 20186853 DOI: 10.1002/Ana.21843 |
0.401 |
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| 2010 |
Kosicek M, Malnar M, Goate A, Hecimovic S. Cholesterol accumulation in Niemann Pick type C (NPC) model cells causes a shift in APP localization to lipid rafts Biochemical and Biophysical Research Communications. 393: 404-409. PMID 20138836 DOI: 10.1016/J.Bbrc.2010.02.007 |
0.33 |
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| 2010 |
Kauwe JS, Bertelsen S, Mayo K, Cruchaga C, Abraham R, Hollingworth P, Harold D, Owen MJ, Williams J, Lovestone S, Morris JC, Goate AM. Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 153: 955-9. PMID 20029940 DOI: 10.1002/Ajmg.B.31053 |
0.812 |
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| 2010 |
Wang J, Van Damme P, Cruchaga C, Gitcho MA, Vidal JM, Seijo-Martínez M, Wang L, Wu JY, Robberecht W, Goate A. Pathogenic cysteine mutations affect progranulin function and production of mature granulins Journal of Neurochemistry. 112: 1305-1315. PMID 20028451 DOI: 10.1111/J.1471-4159.2009.06546.X |
0.644 |
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| 2010 |
Hinrichs AL, Mintun MA, Head D, Fagan AM, Holtzman DM, Morris JC, Goate AM. Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease. Biological Psychiatry. 67: 581-3. PMID 19892322 DOI: 10.1016/J.Biopsych.2009.09.012 |
0.451 |
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| 2010 |
Xuei X, Flury-Wetherill L, Dick D, Goate A, Tischfield J, Nurnberger J, Schuckit M, Kramer J, Kuperman S, Hesselbrock V, Porjesz B, Foroud T, Edenberg HJ. GABRR1 and GABRR2, encoding the GABA-A receptor subunits ρ1 and ρ2, are associated with alcohol dependence American Journal of Medical Genetics, Part B: Neuropsychiatric Genetics. 153: 418-427. PMID 19536785 DOI: 10.1002/Ajmg.B.30995 |
0.317 |
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| 2010 |
Cruchaga C, Graff C, Chiang H, Wang J, Hinrichs AL, Mayo K, Norton J, Morris JC, Goate AM. P1-091: TMEM106B gene polymorphism is associated with age at onset in granulin mutation carriers and plasma granulin protein levels in healthy individuals Alzheimer's & Dementia. 6: S200-S200. DOI: 10.1016/J.Jalz.2010.05.639 |
0.642 |
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| 2010 |
Karch CM, Jeng A, Cruchaga C, Kauwe JS, Renaud N, Fagan AM, Holtzman DM, Morris JC, Goate AM. P1-090: The effects of Alzheimer's disease associated transferrin variants on APP metabolism Alzheimer's & Dementia. 6: S200-S200. DOI: 10.1016/J.Jalz.2010.05.638 |
0.831 |
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| 2010 |
Cruchaga C, Chakraverty S, Haller G, Kevin M, Vallania FL, Robi MD, Bird TD, Diaz-Arrestia R, Boeve B, Bradley B, Graff-Radford NR, Mayeux R, Goate A. Implications and frequency of APP, PSEN1, PSEN2, GRN and MAPT mutation in a well-characterized series of late-onset Alzheimer families Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.615 |
0.655 |
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| 2010 |
Cruchaga C, Kauwe JS, Mayo K, Bertelsen S, Nowotny P, Shah AR, Abraham R, Hollingworth P, Harold D, Owen MJ, Williams J, Lovestone S, Morris JC, Fagan AM, Holtzman DM, ... Goate AM, et al. SNPs associated with CSF tau levels modify rate of progression in Alzheimer's disease Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.612 |
0.8 |
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| 2010 |
Kauwe JSK, Cruchaga C, Bertelsen S, Mayo K, Latu W, Nowotny P, Hinrichs AL, Fagan AM, Holtzman DM, Goate AM. Validating predicted biological effects of Alzheimer's disease associated SNPs using cerebrospinal fluid biomarker levels Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.348 |
0.69 |
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| 2010 |
Hata S, Urakami K, Fagan A, Peskind E, Akatsu H, Maeda M, Levey A, Chung KA, Montine T, Leverenz J, Goate A, Bateman R, Holtzman DM, Gandy S, Suzuki T. P3-171: Gamma-secretase dysfunction in sporadic Alzhemer's disease suggested by p3-Alc peptide, metabolic product of Alcadein Alzheimer's & Dementia. 6: S499-S500. DOI: 10.1016/J.Jalz.2010.05.1669 |
0.333 |
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| 2009 |
Chen LS, Johnson EO, Breslau N, Hatsukami D, Saccone NL, Grucza RA, Wang JC, Hinrichs AL, Fox L, Goate AM, Rice JP, Bierut LJ. Interplay of Genetic Risk Factors and Parent Monitoring in Risk for Nicotine Dependence. Addiction (Abingdon, England). 104: 1731-1740. PMID 20871796 DOI: 10.1111/J.1360-0443.2009.02697.X |
0.339 |
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| 2009 |
Morris JC, Roe CM, Grant EA, Head D, Storandt M, Goate AM, Fagan AM, Holtzman DM, Mintun MA. Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease. Archives of Neurology. 66: 1469-75. PMID 20008650 DOI: 10.1001/Archneurol.2009.269 |
0.412 |
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| 2009 |
Blom ES, Giedraitis V, Arepalli S, Hamshere ML, Adighibe O, Goate A, Williams J, Lannfelt L, Hardy J, Vrièze FW, Glaser A. Further analysis of previously implicated linkage regions for Alzheimer's disease in affected relative pairs. Bmc Medical Genetics. 10: 122. PMID 19951422 DOI: 10.1186/1471-2350-10-122 |
0.585 |
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| 2009 |
Simón-Sánchez J, Schulte C, Bras JM, Sharma M, Gibbs JR, Berg D, Paisan-Ruiz C, Lichtner P, Scholz SW, Hernandez DG, Krüger R, Federoff M, Klein C, Goate A, Perlmutter J, et al. Genome-wide association study reveals genetic risk underlying Parkinson's disease. Nature Genetics. 41: 1308-12. PMID 19915575 DOI: 10.1038/Ng.487 |
0.692 |
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| 2009 |
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Goate AM, et al. Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease. Nature Genetics. 41: 1088-93. PMID 19734902 DOI: 10.1038/Ng.440 |
0.838 |
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| 2009 |
Wang JC, Bierut LJ, Goate AM. Variants weakly correlated with CHRNA5 D398N polymorphism should be considered in transcriptional deregulation at the 15q25 locus associated with lung cancer risk. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. 15: 5599; author reply 5. PMID 19706810 DOI: 10.1158/1078-0432.Ccr-09-1108 |
0.304 |
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| 2009 |
Saccone NL, Wang JC, Breslau N, Johnson EO, Hatsukami D, Saccone SF, Grucza RA, Sun L, Duan W, Budde J, Culverhouse RC, Fox L, Hinrichs AL, Steinbach JH, Wu M, ... ... Goate AM, et al. The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans. Cancer Research. 69: 6848-56. PMID 19706762 DOI: 10.1158/0008-5472.Can-09-0786 |
0.322 |
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| 2009 |
Norton JB, Cairns NJ, Chakraverty S, Wang J, Levitch D, Galvin JE, Goate A. Presenilin1 G217R mutation linked to Alzheimer disease with cotton wool plaques. Neurology. 73: 480-2. PMID 19667325 DOI: 10.1212/Wnl.0B013E3181B163Ba |
0.39 |
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| 2009 |
Fenoglio C, Galimberti D, Cortini F, Kauwe JS, Cruchaga C, Venturelli E, Villa C, Serpente M, Scalabrini D, Mayo K, Piccio LM, Clerici F, Albani D, Mariani C, Forloni G, ... ... Goate AM, et al. Rs5848 variant influences GRN mRNA levels in brain and peripheral mononuclear cells in patients with Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 18: 603-12. PMID 19625741 DOI: 10.3233/Jad-2009-1170 |
0.788 |
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| 2009 |
Gitcho MA, Bigio EH, Mishra M, Johnson N, Weintraub S, Mesulam M, Rademakers R, Chakraverty S, Cruchaga C, Morris JC, Goate AM, Cairns NJ. TARDBP 3'-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy. Acta Neuropathologica. 118: 633-45. PMID 19618195 DOI: 10.1007/S00401-009-0571-7 |
0.671 |
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| 2009 |
Wang JC, Cruchaga C, Saccone NL, Bertelsen S, Liu P, Budde JP, Duan W, Fox L, Grucza RA, Kern J, Mayo K, Reyes O, Rice J, Saccone SF, Spiegel N, ... ... Goate AM, et al. Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5. Human Molecular Genetics. 18: 3125-35. PMID 19443489 DOI: 10.1093/Hmg/Ddp231 |
0.627 |
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| 2009 |
Saccone NL, Saccone SF, Hinrichs AL, Stitzel JA, Duan W, Pergadia ML, Agrawal A, Breslau N, Grucza RA, Hatsukami D, Johnson EO, Madden PA, Swan GE, Wang JC, Goate AM, et al. Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 453-66. PMID 19259974 DOI: 10.1002/Ajmg.B.30828 |
0.325 |
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| 2009 |
Gitcho MA, Strider J, Carter D, Taylor-Reinwald L, Forman MS, Goate AM, Cairns NJ. VCP mutations causing frontotemporal lobar degeneration disrupt localization of TDP-43 and induce cell death. The Journal of Biological Chemistry. 284: 12384-98. PMID 19237541 DOI: 10.1074/Jbc.M900992200 |
0.359 |
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| 2009 |
Agrawal A, Pergadia ML, Balasubramanian S, Saccone SF, Hinrichs AL, Saccone NL, Breslau N, Johnson EO, Hatsukami D, Martin NG, Montgomery GW, Goate AM, Rice JP, Bierut LJ, Madden PA. Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence. Addiction (Abingdon, England). 104: 471-7. PMID 19207358 DOI: 10.1111/J.1360-0443.2008.02445.X |
0.349 |
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| 2009 |
Pergadia ML, Agrawal A, Loukola A, Montgomery GW, Broms U, Saccone SF, Wang JC, Todorov AA, Heikkilä K, Statham DJ, Henders AK, Campbell MJ, Rice JP, Todd RD, Heath AC, ... Goate AM, et al. Genetic linkage findings for DSM-IV nicotine withdrawal in two populations. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 950-9. PMID 19180564 DOI: 10.1002/Ajmg.B.30924 |
0.322 |
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| 2009 |
Kauwe JS, Wang J, Mayo K, Morris JC, Fagan AM, Holtzman DM, Goate AM. Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta. Neurogenetics. 10: 13-7. PMID 18813964 DOI: 10.1007/S10048-008-0150-4 |
0.7 |
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| 2009 |
Chen AC, Tang Y, Rangaswamy M, Wang JC, Almasy L, Foroud T, Edenberg HJ, Hesselbrock V, Nurnberger J, Kuperman S, O'Connor SJ, Schuckit MA, Bauer LO, Tischfield J, Rice JP, ... ... Goate A, et al. Association of single nucleotide polymorphisms in a glutamate receptor gene (GRM8) with theta power of event-related oscillations and alcohol dependence. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 150: 359-68. PMID 18618593 DOI: 10.1002/Ajmg.B.30818 |
0.333 |
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| 2009 |
Wang JC, Grucza R, Cruchaga C, Hinrichs AL, Bertelsen S, Budde JP, Fox L, Goldstein E, Reyes O, Saccone N, Saccone S, Xuei X, Bucholz K, Kuperman S, Nurnberger J, ... ... Goate AM, et al. Genetic variation in the CHRNA5 gene affects mRNA levels and is associated with risk for alcohol dependence. Molecular Psychiatry. 14: 501-10. PMID 18414406 DOI: 10.1038/Mp.2008.42 |
0.646 |
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| 2009 |
Harold D, Abraham R, Hollingworth P, Sims R, Gerrish A, Hamshere ML, Pahwa JS, Moskvina V, Dowzell K, Williams A, Jones N, Thomas C, Stretton A, Morgan AR, Lovestone S, ... ... Goate AM, et al. Erratum: Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease Nature Genetics. 41: 1156-1156. DOI: 10.1038/Ng1009-1156D |
0.84 |
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| 2009 |
Cruchaga C, Kauwe JS, Mayo K, Bertelsen S, Nowotny P, Shah AR, Fagan AM, Holtzman DM, Morris JC, Goate AM. P4-136: SNPs in catalytic and regulatory subunits of calcineurin are associated with CSF tau levels and mRNA levels Alzheimer's & Dementia. 5: P471-P472. DOI: 10.1016/J.Jalz.2009.04.804 |
0.726 |
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| 2009 |
Harold D, Hollingworth P, Hamshere M, Holmans P, Abraham R, Sims R, Gerrish A, Lovestone S, Brayne C, Gill M, Lawlor B, Passmore P, Nothen M, Maier W, Livingston G, ... ... Goate A, et al. P4-133: Genome-wide association study of age at onset of Alzheimer's disease Alzheimer's & Dementia. 5: P471-P471. DOI: 10.1016/J.Jalz.2009.04.801 |
0.566 |
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| 2009 |
Gerrish A, Harold D, Sims R, Abraham R, Hollingworth P, Hamshere M, Lovestone S, Brayne C, Gill M, Lawlor B, Passmore P, Nothen M, Mayer W, Livingston G, Bass N, ... Goate A, et al. P4-124: An examination of previously reported Alzheimer candidate genes within a large genome-wide association dataset Alzheimer's & Dementia. 5: P468-P468. DOI: 10.1016/J.Jalz.2009.04.792 |
0.531 |
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| 2009 |
Hollingworth P, Sims R, Abraham R, Harold D, Gerrish A, Hamshere M, Lovestone S, Brayne C, Gill M, Lawlor B, Passmore P, Nothen M, Mayer W, Livingston G, Bass N, ... Goate A, et al. P4-121: Genome-wide association study of Alzheimer's with psychotic symptoms Alzheimer's & Dementia. 5: P467-P467. DOI: 10.1016/J.Jalz.2009.04.789 |
0.502 |
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| 2009 |
Sims R, Hollingworth P, Abraham R, Harold D, Holmans P, Lovestone S, Powell J, Brayne C, Rubinsztein DC, Gill M, Lawlor B, Craig D, Passmore P, Nöthen M, Mayer W, ... ... Goate A, et al. P4-120: Investigating psychosis candidate genes in Alzheimer's disease with psychosis using genome-wide association studies Alzheimer's & Dementia. 5: P466-P467. DOI: 10.1016/J.Jalz.2009.04.788 |
0.65 |
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| 2009 |
Hata S, Maeda M, Nishimura M, Levey A, Chung KA, Montine T, Fagan A, Goate A, Bateman R, Holtzman DM, Nakaya T, Gandy S, Suzuki T. P2-190: p3-Alc peptides produced by covariant processing of Alcadein and APP implicate γ-secretase dysfunction in sporadic Alzheimer's disease Alzheimer's & Dementia. 5: P316-P317. DOI: 10.1016/J.Jalz.2009.04.502 |
0.4 |
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| 2008 |
Goate A. Interview with Alison Goate. Biomarkers in Medicine. 2: 541. PMID 20477443 DOI: 10.2217/17520363.2.6.541 |
0.463 |
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| 2008 |
Saccone NL, Saccone SF, Goate AM, Grucza RA, Hinrichs AL, Rice JP, Bierut LJ. In search of causal variants: refining disease association signals using cross-population contrasts. Bmc Genetics. 9: 58. PMID 18759969 DOI: 10.1186/1471-2156-9-58 |
0.359 |
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| 2008 |
Saccone SF, Saccone NL, Swan GE, Madden PA, Goate AM, Rice JP, Bierut LJ. Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence. Bioinformatics (Oxford, England). 24: 1805-11. PMID 18565990 DOI: 10.1093/Bioinformatics/Btn315 |
0.372 |
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| 2008 |
Kauwe JS, Cruchaga C, Mayo K, Fenoglio C, Bertelsen S, Nowotny P, Galimberti D, Scarpini E, Morris JC, Fagan AM, Holtzman DM, Goate AM. Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition. Proceedings of the National Academy of Sciences of the United States of America. 105: 8050-4. PMID 18541914 DOI: 10.1073/Pnas.0801227105 |
0.787 |
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| 2008 |
Agrawal A, Pergadia ML, Saccone SF, Lynskey MT, Wang JC, Martin NG, Statham D, Henders A, Campbell M, Garcia R, Broms U, Todd RD, Goate AM, Rice J, Kaprio J, et al. An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project. Archives of General Psychiatry. 65: 713-21. PMID 18519829 DOI: 10.1001/Archpsyc.65.6.713 |
0.329 |
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| 2008 |
Bierut LJ, Stitzel JA, Wang JC, Hinrichs AL, Grucza RA, Xuei X, Saccone NL, Saccone SF, Bertelsen S, Fox L, Horton WJ, Breslau N, Budde J, Cloninger CR, Dick DM, ... ... Goate AM, et al. Variants in nicotinic receptors and risk for nicotine dependence. The American Journal of Psychiatry. 165: 1163-71. PMID 18519524 DOI: 10.1176/Appi.Ajp.2008.07111711 |
0.336 |
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| 2008 |
Agrawal A, Pergadia ML, Saccone SF, Hinrichs AL, Lessov-Schlaggar CN, Saccone NL, Neuman RJ, Breslau N, Johnson E, Hatsukami D, Montgomery GW, Heath AC, Martin NG, Goate AM, Rice JP, et al. Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study. Addiction (Abingdon, England). 103: 1027-38. PMID 18482426 DOI: 10.1111/J.1360-0443.2008.02236.X |
0.326 |
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| 2008 |
Kauwe JS, Wang J, Chakraverty S, Goate AM, Henao-Martinez AF. Novel presenilin 1 variant (P117A) causing Alzheimer's disease in the fourth decade of life. Neuroscience Letters. 438: 257-9. PMID 18479822 DOI: 10.1016/J.Neulet.2008.04.029 |
0.707 |
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| 2008 |
Gitcho MA, Baloh RH, Chakraverty S, Mayo K, Norton JB, Levitch D, Hatanpaa KJ, White CL, Bigio EH, Caselli R, Baker M, Al-Lozi MT, Morris JC, Pestronk A, Rademakers R, ... Goate AM, et al. TDP-43 A315T mutation in familial motor neuron disease. Annals of Neurology. 63: 535-8. PMID 18288693 DOI: 10.1002/Ana.21344 |
0.356 |
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| 2008 |
Mukherjee O, Wang J, Gitcho M, Chakraverty S, Taylor-Reinwald L, Shears S, Kauwe JS, Norton J, Levitch D, Bigio EH, Hatanpaa KJ, White CL, Morris JC, Cairns NJ, Goate A. Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia. Human Mutation. 29: 512-21. PMID 18183624 DOI: 10.1002/Humu.20681 |
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Dick DM, Aliev F, Wang JC, Saccone S, Hinrichs A, Bertelsen S, Budde J, Saccone N, Foroud T, Nurnberger J, Xuei X, Conneally PM, Schuckit M, Almasy L, Crowe R, ... ... Goate A, et al. A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9. Biological Psychiatry. 63: 1047-53. PMID 18163977 DOI: 10.1016/J.Biopsych.2007.11.005 |
0.345 |
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| 2008 |
Blom ES, Holmans P, Arepalli S, Adighibe O, Hamshere ML, Gatz M, Pedersen NL, Bergem AL, Owen MJ, Hollingworth P, Goate A, Williams J, Lannfelt L, Hardy J, Wavrant-De Vrièze F, et al. Does APOE explain the linkage of Alzheimer's disease to chromosome 19q13? American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 147: 778-83. PMID 18161859 DOI: 10.1002/Ajmg.B.30681 |
0.562 |
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| 2008 |
Li Y, Grupe A, Rowland C, Holmans P, Segurado R, Abraham R, Jones L, Catanese J, Ross D, Mayo K, Martinez M, Hollingworth P, Goate A, Cairns NJ, Racette BA, et al. Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease. Human Molecular Genetics. 17: 759-67. PMID 18063669 DOI: 10.1093/Hmg/Ddm348 |
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| 2008 |
Li Y, Rowland C, Catanese J, Morris J, Lovestone S, O'Donovan MC, Goate A, Owen M, Williams J, Grupe A. SORL1 variants and risk of late-onset Alzheimer's disease. Neurobiology of Disease. 29: 293-6. PMID 17949987 DOI: 10.1016/J.Nbd.2007.09.001 |
0.543 |
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| 2008 |
Kauwe JS, Cruchaga C, Mayo K, Fenoglio C, Bertelsen S, Nowotny P, Galimberti D, Scarpini E, Shah AR, Morris JC, Fagan AM, Holtzman DM, Goate AM. O2-06-06: SNPS in MAPT are associated with cerebrospinal fluid Tau levels, MAPT mRNA levels, and age at onset of late-onset Alzheimer's disease Alzheimer's & Dementia. 4: T145-T145. DOI: 10.1016/J.Jalz.2008.05.354 |
0.687 |
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| 2008 |
Goate AM, Kauwe JS, Mayo K, Bertelsen S, Shah AR, Morris JC, Fagan AM, Holtzman DM. O2-06-03: Late-onset Alzheimer's Disease-associated SNPS in TOMM40 and APOE have different effects on cerebrospinal fluid amyloid-beta levels Alzheimer's & Dementia. 4: T144-T144. DOI: 10.1016/J.Jalz.2008.05.351 |
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| 2008 |
Hinrichs AL, Mintun M, Head D, Fagan AM, Holtzman DM, Morris JC, Goate A. IC-01-01: Cortical binding of Pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease Alzheimer's & Dementia. 4: T2-T2. DOI: 10.1016/J.Jalz.2008.05.2487 |
0.365 |
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| 2008 |
Gitcho MA, Baloh RH, Chakraverty S, Mayo K, Norton JB, Levitch D, Hatanpaa KJ, White CH, Bigio EH, Caselli R, Baker M, Al-Lozi MT, Morris JC, Pestronk A, Rademakers R, ... Goate AM, et al. P3-287: TDP-43 A315T mutation in familial motor neuron disease Alzheimer's & Dementia. 4: T606-T607. DOI: 10.1016/J.Jalz.2008.05.1855 |
0.319 |
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| 2008 |
Kauwe JS, Mayo K, Bertelsen S, Shah AR, Morris JC, Fagan AM, Holtzman DM, Goate AM. P3-232: SNPs in SOAT1, TFAM, and CNDP1 are associated with cerebrospinal fluid amyloid-beta levels Alzheimer's & Dementia. 4: T588-T589. DOI: 10.1016/J.Jalz.2008.05.1799 |
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| 2008 |
Fenoglio C, Cortini F, Venturelli E, Guidi I, Scalabrini D, Villa C, Kauwe JSK, Mayo K, Valle ED, Lovati C, Mariani C, Scarpini E, Bresolin N, Goate AM, Galimberti D. P3-217: Genetic and functional analysis of progranulin gene variants in patients with Alzheimer's disease Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1784 |
0.486 |
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| 2008 |
Cruchaga C, Kauwe J, Mayo K, Bertelsen S, Nowotny P, Shah AR, Fagan AM, Holtzman DM, Morris JC, Goate A. P3-214: Cerebrospinal fluid tau levels, an endophenotype for genetic studies of Alzheimer's disease Alzheimer's & Dementia. 4: T583-T583. DOI: 10.1016/J.Jalz.2008.05.1781 |
0.789 |
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| 2008 |
Malnar M, Kosicek M, Goate A, Hecimovic S. P1-443: Increased Aβ formation in CHO NPC1-null cells is not directly related to cholesterol levels Alzheimers & Dementia. 4. DOI: 10.1016/J.Jalz.2008.05.1025 |
0.317 |
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| 2007 |
Hu Y, Hosseini A, Kauwe JS, Gross J, Cairns NJ, Goate AM, Fagan AM, Townsend RR, Holtzman DM. Identification and validation of novel CSF biomarkers for early stages of Alzheimer's disease. Proteomics. Clinical Applications. 1: 1373-84. PMID 21136637 DOI: 10.1002/Prca.200600999 |
0.666 |
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| 2007 |
Dick DM, Wang JC, Plunkett J, Aliev F, Hinrichs A, Bertelsen S, Budde JP, Goldstein EL, Kaplan D, Edenberg HJ, Nurnberger J, Hesselbrock V, Schuckit M, Kuperman S, Tischfield J, ... ... Goate A, et al. Family-based association analyses of alcohol dependence phenotypes across DRD2 and neighboring gene ANKK1. Alcoholism, Clinical and Experimental Research. 31: 1645-53. PMID 17850642 DOI: 10.1111/J.1530-0277.2007.00470.X |
0.31 |
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| 2007 |
Hamshere ML, Holmans PA, Avramopoulos D, Bassett SS, Blacker D, Bertram L, Wiener H, Rochberg N, Tanzi RE, Myers A, Wavrant-De Vrièze F, Go R, Fallin D, Lovestone S, Hardy J, ... Goate A, et al. Genome-wide linkage analysis of 723 affected relative pairs with late-onset Alzheimer's disease. Human Molecular Genetics. 16: 2703-12. PMID 17725986 DOI: 10.1093/Hmg/Ddm224 |
0.713 |
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| 2007 |
Sagare A, Deane R, Bell RD, Johnson B, Hamm K, Pendu R, Marky A, Lenting PJ, Wu Z, Zarcone T, Goate A, Mayo K, Perlmutter D, Coma M, Zhong Z, et al. Clearance of amyloid-beta by circulating lipoprotein receptors. Nature Medicine. 13: 1029-31. PMID 17694066 DOI: 10.1038/Nm1635 |
0.375 |
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| 2007 |
Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, ... Goate AM, et al. TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. The American Journal of Pathology. 171: 227-40. PMID 17591968 DOI: 10.2353/Ajpath.2007.070182 |
0.386 |
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| 2007 |
Hollingworth P, Hamshere ML, Holmans PA, O'Donovan MC, Sims R, Powell J, Lovestone S, Myers A, DeVrieze FW, Hardy J, Goate A, Owen M, Williams J. Increased familial risk and genomewide significant linkage for Alzheimer's disease with psychosis. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 841-8. PMID 17492769 DOI: 10.1002/Ajmg.B.30515 |
0.76 |
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| 2007 |
Nowotny P, Bertelsen S, Hinrichs AL, Kauwe JS, Mayo K, Jacquart S, Morris JC, Goate A. Association studies between common variants in prolyl isomerase Pin1 and the risk for late-onset Alzheimer's disease. Neuroscience Letters. 419: 15-7. PMID 17482359 DOI: 10.1016/J.Neulet.2007.03.071 |
0.717 |
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| 2007 |
Wahrle SE, Shah AR, Fagan AM, Smemo S, Kauwe JS, Grupe A, Hinrichs A, Mayo K, Jiang H, Thal LJ, Goate AM, Holtzman DM. Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1 polymorphisms. Molecular Neurodegeneration. 2: 7. PMID 17430597 DOI: 10.1186/1750-1326-2-7 |
0.661 |
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| 2007 |
Nowotny P, Simcock X, Bertelsen S, Hinrichs AL, Kauwe JS, Mayo K, Smemo S, Morris JC, Goate A. Association studies testing for risk for late-onset Alzheimer's disease with common variants in the beta-amyloid precursor protein (APP). American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 144: 469-74. PMID 17427190 DOI: 10.1002/Ajmg.B.30485 |
0.715 |
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| 2007 |
Schymick JC, Yang Y, Andersen PM, Vonsattel JP, Greenway M, Momeni P, Elder J, Chiò A, Restagno G, Robberecht W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli RJ, et al. Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes. Journal of Neurology, Neurosurgery, and Psychiatry. 78: 754-6. PMID 17371905 DOI: 10.1136/Jnnp.2006.109553 |
0.64 |
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| 2007 |
Kauwe JS, Jacquart S, Chakraverty S, Wang J, Mayo K, Fagan AM, Holtzman DM, Morris JC, Goate AM. Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation. Annals of Neurology. 61: 446-53. PMID 17366635 DOI: 10.1002/Ana.21099 |
0.693 |
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| 2007 |
Behrens MI, Mukherjee O, Tu PH, Liscic RM, Grinberg LT, Carter D, Paulsmeyer K, Taylor-Reinwald L, Gitcho M, Norton JB, Chakraverty S, Goate AM, Morris JC, Cairns NJ. Neuropathologic heterogeneity in HDDD1: a familial frontotemporal lobar degeneration with ubiquitin-positive inclusions and progranulin mutation. Alzheimer Disease and Associated Disorders. 21: 1-7. PMID 17334266 DOI: 10.1097/Wad.0B013E31803083F2 |
0.413 |
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| 2007 |
Grupe A, Abraham R, Li Y, Rowland C, Hollingworth P, Morgan A, Jehu L, Segurado R, Stone D, Schadt E, Karnoub M, Nowotny P, Tacey K, Catanese J, Sninsky J, ... ... Goate A, et al. Evidence for novel susceptibility genes for late-onset Alzheimer's disease from a genome-wide association study of putative functional variants. Human Molecular Genetics. 16: 865-73. PMID 17317784 DOI: 10.1093/Hmg/Ddm031 |
0.548 |
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| 2007 |
Mukherjee O, Kauwe JS, Mayo K, Morris JC, Goate AM. Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease. Bmc Genetics. 8: 3. PMID 17266761 DOI: 10.1186/1471-2156-8-3 |
0.696 |
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| 2007 |
Wang JC, Hinrichs AL, Bertelsen S, Stock H, Budde JP, Dick DM, Bucholz KK, Rice J, Saccone N, Edenberg HJ, Hesselbrock V, Kuperman S, Schuckit MA, Bierut LJ, Goate AM. Functional variants in TAS2R38 and TAS2R16 influence alcohol consumption in high-risk families of African-American origin. Alcoholism, Clinical and Experimental Research. 31: 209-15. PMID 17250611 DOI: 10.1111/J.1530-0277.2006.00297.X |
0.322 |
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| 2007 |
Dick DM, Aliev F, Kramer J, Wang JC, Hinrichs A, Bertelsen S, Kuperman S, Schuckit M, Nurnberger J, Edenberg HJ, Porjesz B, Begleiter H, Hesselbrock V, Goate A, Bierut L. Association of CHRM2 with IQ: converging evidence for a gene influencing intelligence. Behavior Genetics. 37: 265-72. PMID 17160701 DOI: 10.1007/S10519-006-9131-2 |
0.342 |
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| 2007 |
Bierut LJ, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau OF, Swan GE, Rutter J, Bertelsen S, Fox L, Fugman D, Goate AM, Hinrichs AL, Konvicka K, Martin NG, et al. Novel genes identified in a high-density genome wide association study for nicotine dependence. Human Molecular Genetics. 16: 24-35. PMID 17158188 DOI: 10.1093/Hmg/Ddl441 |
0.367 |
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| 2007 |
Saccone SF, Hinrichs AL, Saccone NL, Chase GA, Konvicka K, Madden PA, Breslau N, Johnson EO, Hatsukami D, Pomerleau O, Swan GE, Goate AM, Rutter J, Bertelsen S, Fox L, et al. Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Human Molecular Genetics. 16: 36-49. PMID 17135278 DOI: 10.1093/Hmg/Ddl438 |
0.32 |
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| 2006 |
Mukherjee O, Pastor P, Cairns NJ, Chakraverty S, Kauwe JS, Shears S, Behrens MI, Budde J, Hinrichs AL, Norton J, Levitch D, Taylor-Reinwald L, Gitcho M, Tu PH, Tenenholz Grinberg L, ... ... Goate AM, et al. HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin. Annals of Neurology. 60: 314-22. PMID 16983685 DOI: 10.1002/Ana.20963 |
0.78 |
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| 2006 |
Goate A. Segregation of a missense mutation in the amyloid beta-protein precursor gene with familial Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 9: 341-7. PMID 16914872 DOI: 10.3233/Jad-2006-9S338 |
0.467 |
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| 2006 |
Li Y, Grupe A, Rowland C, Nowotny P, Kauwe JS, Smemo S, Hinrichs A, Tacey K, Toombs TA, Kwok S, Catanese J, White TJ, Maxwell TJ, Hollingworth P, Abraham R, ... ... Goate A, et al. DAPK1 variants are associated with Alzheimer's disease and allele-specific expression. Human Molecular Genetics. 15: 2560-8. PMID 16847012 DOI: 10.1093/Hmg/Ddl178 |
0.718 |
|
| 2006 |
Jones KA, Porjesz B, Almasy L, Bierut L, Dick D, Goate A, Hinrichs A, Rice JP, Wang JC, Bauer LO, Crowe R, Foroud T, Hesselbrock V, Kuperman S, Nurnberger J, et al. A cholinergic receptor gene (CHRM2) affects event-related oscillations. Behavior Genetics. 36: 627-39. PMID 16823639 DOI: 10.1007/S10519-006-9075-6 |
0.312 |
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| 2006 |
Walker ES, Martinez M, Wang J, Goate A. Conserved residues in juxtamembrane region of the extracellular domain of nicastrin are essential for gamma-secretase complex formation. Journal of Neurochemistry. 98: 300-9. PMID 16805816 DOI: 10.1111/J.1471-4159.2006.03881.X |
0.621 |
|
| 2006 |
Edenberg HJ, Xuei X, Chen HJ, Tian H, Wetherill LF, Dick DM, Almasy L, Bierut L, Bucholz KK, Goate A, Hesselbrock V, Kuperman S, Nurnberger J, Porjesz B, Rice J, et al. Association of alcohol dehydrogenase genes with alcohol dependence: a comprehensive analysis. Human Molecular Genetics. 15: 1539-49. PMID 16571603 DOI: 10.1093/Hmg/Ddl073 |
0.326 |
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| 2006 |
Hinrichs AL, Wang JC, Bufe B, Kwon JM, Budde J, Allen R, Bertelsen S, Evans W, Dick D, Rice J, Foroud T, Nurnberger J, Tischfield JA, Kuperman S, Crowe R, ... ... Goate AM, et al. Functional variant in a bitter-taste receptor (hTAS2R16) influences risk of alcohol dependence. American Journal of Human Genetics. 78: 103-11. PMID 16385453 DOI: 10.1086/499253 |
0.335 |
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| 2006 |
Grupe A, Li Y, Rowland C, Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell TJ, Cherny S, Doil L, Tacey K, van Luchene R, Myers A, Wavrant-De Vrièze F, Kaleem M, ... ... Goate A, et al. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. American Journal of Human Genetics. 78: 78-88. PMID 16385451 DOI: 10.1086/498851 |
0.787 |
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| 2006 |
Dick DM, Jones K, Saccone N, Hinrichs A, Wang JC, Goate A, Bierut L, Almasy L, Schuckit M, Hesselbrock V, Tischfield J, Foroud T, Edenberg H, Porjesz B, Begleiter H. Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholism. Behavior Genetics. 36: 112-26. PMID 16341909 DOI: 10.1007/S10519-005-9001-3 |
0.319 |
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| 2006 |
Dick DM, Aliev F, Bierut L, Goate A, Rice J, Hinrichs A, Bertelsen S, Wang JC, Dunn G, Kuperman S, Schuckit M, Nurnberger J, Porjesz B, Beglieter H, Kramer J, et al. Linkage analyses of IQ in the collaborative study on the genetics of alcoholism (COGA) sample. Behavior Genetics. 36: 77-86. PMID 16341907 DOI: 10.1007/S10519-005-9009-8 |
0.355 |
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| 2006 |
Wang J, Beher D, Nyborg AC, Shearman MS, Golde TE, Goate A. C-terminal PAL motif of presenilin and presenilin homologues required for normal active site conformation. Journal of Neurochemistry. 96: 218-27. PMID 16305624 DOI: 10.1111/J.1471-4159.2005.03548.X |
0.316 |
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| 2006 |
Smemo S, Nowotny P, Hinrichs AL, Kauwe JS, Cherny S, Erickson K, Myers AJ, Kaleem M, Marlowe L, Gibson AM, Hollingworth P, O'Donovan MC, Morris CM, Holmans P, Lovestone S, ... ... Goate A, et al. Ubiquilin 1 polymorphisms are not associated with late-onset Alzheimer's disease. Annals of Neurology. 59: 21-6. PMID 16278862 DOI: 10.1002/Ana.20673 |
0.793 |
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| 2006 |
Grupe A, Li Y, Rowland C, Hinrichs T, Holmans P, Hardy J, O'Donovan M, Owen MJ, Williams J, Goate A. Reply to Bertram et al. [2] American Journal of Human Genetics. 79: 183-184. DOI: 10.1086/505033 |
0.582 |
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| 2006 |
Meimaridou E, Afzal S, Nowotny P, Goate A, Killick R, Lovestone S. P1-413: SORBS1, c-ABL and c-CBL; insulin signalling proteins in Alzheimer's disease Alzheimer's & Dementia. 2: S218-S219. DOI: 10.1016/J.Jalz.2006.05.792 |
0.341 |
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| 2006 |
Hollingworth P, Hamshere M, Holmans P, Jones L, O'Donavan M, Myers A, Hardy J, Goate A, Lovestone S, Owen M, Williams J. P1-331: Familiality and linkage analysis of behavioral symptoms and age at disease onset in late-onset Alzheimer's disease Alzheimer's & Dementia. 2: S194-S194. DOI: 10.1016/J.Jalz.2006.05.709 |
0.733 |
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| 2006 |
Wang J, Grupe A, Li Y, Nowotny P, Goate A. P1-299: Sorbs 1, a candidate gene for the chromosome 10 late onset Alzheimer’s disease locus Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.676 |
0.382 |
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| 2006 |
Cairns NJ, Tu P, Pastor P, Norton J, Chakraverty S, Mukherjee O, Carter D, Behrens MI, Morris JC, Goate A. P4-108: Hereditary dysphasic disinhibition dementia 2 is a chromosome 17q21-linked frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions Alzheimer's & Dementia. 2: S546-S546. DOI: 10.1016/J.Jalz.2006.05.1847 |
0.67 |
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| 2006 |
Li Y, Grupe A, Rowland C, Nowotny P, Kauwe JSK, Smemo S, Hinrichs A, Tacey K, Kwok S, Catanese J, Sninsky J, White TJ, Hollingworth P, Harris SL, Levine A, ... ... Goate A, et al. O2-02-07 Alzheimers & Dementia. 2. DOI: 10.1016/J.Jalz.2006.05.117 |
0.454 |
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| 2006 |
Grupe A, Li Y, Rowland C, Abraham R, Hollingworth P, Morgan A, Jehu L, Stone D, Schadt E, Karnoub M, Nowotny P, Tacey K, Catanese J, Sninsky J, Rubinsztein D, ... ... Goate A, et al. O2-02-05: Novel candidate genes for late-onset Alzheimer's disease from a large scale association study of 20K functional variants Alzheimer's & Dementia. 2: S33-S33. DOI: 10.1016/J.Jalz.2006.05.115 |
0.531 |
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| 2006 |
Goate AM. S2-01-03: Systematic screens identify novel genes for load susceptibility on chromosomes 9 and 10 Alzheimer's & Dementia. 2: S23-S24. DOI: 10.1016/J.Jalz.2006.05.076 |
0.302 |
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| 2006 |
Goate A. Segregation of a missense mutation in the amyloid β-protein precursor gene with familial Alzheimer’s disease Journal of Alzheimer's Disease. 9: 157-161. DOI: 10.1007/978-3-540-37652-1_16 |
0.432 |
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| 2005 |
Snider BJ, Norton J, Coats MA, Chakraverty S, Hou CE, Jervis R, Lendon CL, Goate AM, McKeel DW, Morris JC. Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life. Archives of Neurology. 62: 1821-30. PMID 16344340 DOI: 10.1001/Archneur.62.12.1821 |
0.473 |
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| 2005 |
Brunkan AL, Martinez M, Wang J, Walker ES, Beher D, Shearman MS, Goate AM. Two domains within the first putative transmembrane domain of presenilin 1 differentially influence presenilinase and gamma-secretase activity. Journal of Neurochemistry. 94: 1315-28. PMID 16001967 DOI: 10.1111/J.1471-4159.2005.03278.X |
0.794 |
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| 2005 |
Li Y, Rowland C, Tacey K, Catanese J, Sninsky J, Hardy J, Powell J, Lovestone S, Morris JC, Thal L, Goate A, Owen M, Williams J, Grupe A. The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples. Molecular Psychiatry. 10: 809-10. PMID 15970929 DOI: 10.1038/Sj.Mp.4001702 |
0.636 |
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| 2005 |
Brunkan AL, Martinez M, Walker ES, Goate AM. Presenilin endoproteolysis is an intramolecular cleavage. Molecular and Cellular Neurosciences. 29: 65-73. PMID 15866047 DOI: 10.1016/J.Mcn.2004.12.012 |
0.804 |
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| 2005 |
Nowotny P, Hinrichs AL, Smemo S, Kauwe JS, Maxwell T, Holmans P, Hamshere M, Turic D, Jehu L, Hollingworth P, Moore P, Bryden L, Myers A, Doil LM, Tacey KM, ... ... Goate A, et al. Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 136: 62-8. PMID 15858813 DOI: 10.1002/Ajmg.B.30186 |
0.802 |
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| 2005 |
Brunkan AL, Goate AM. Presenilin function and gamma-secretase activity. Journal of Neurochemistry. 93: 769-92. PMID 15857382 DOI: 10.1111/J.1471-4159.2005.03099.X |
0.827 |
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| 2005 |
Holmans P, Hamshere M, Hollingworth P, Rice F, Tunstall N, Jones S, Moore P, Wavrant DeVrieze F, Myers A, Crook R, Compton D, Marshall H, Meyer D, Shears S, Booth J, ... ... Goate A, et al. Genome screen for loci influencing age at onset and rate of decline in late onset Alzheimer's disease. American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics. 135: 24-32. PMID 15729734 DOI: 10.1002/Ajmg.B.30114 |
0.693 |
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| 2005 |
Brunkan AL, Martinez M, Wang J, Walker ES, Goate AM. A domain at the C-terminus of PS1 is required for presenilinase and gamma-secretase activities. Journal of Neurochemistry. 92: 1158-69. PMID 15715666 DOI: 10.1111/J.1471-4159.2004.02945.X |
0.77 |
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| 2005 |
Li Y, Hollingworth P, Moore P, Foy C, Archer N, Powell J, Nowotny P, Holmans P, O'Donovan M, Tacey K, Doil L, van Luchene R, Garcia V, Rowland C, Lau K, ... ... Goate A, et al. Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease. Human Mutation. 25: 270-7. PMID 15714520 DOI: 10.1002/Humu.20138 |
0.667 |
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| 2005 |
Walker ES, Martinez M, Brunkan AL, Goate A. Presenilin 2 familial Alzheimer's disease mutations result in partial loss of function and dramatic changes in Abeta 42/40 ratios. Journal of Neurochemistry. 92: 294-301. PMID 15663477 DOI: 10.1111/J.1471-4159.2004.02858.X |
0.814 |
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| 2004 |
Li Y, Nowotny P, Holmans P, Smemo S, Kauwe JS, Hinrichs AL, Tacey K, Doil L, van Luchene R, Garcia V, Rowland C, Schrodi S, Leong D, Gogic G, Chan J, ... ... Goate A, et al. Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family. Proceedings of the National Academy of Sciences of the United States of America. 101: 15688-93. PMID 15507493 DOI: 10.1073/Pnas.0403535101 |
0.776 |
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| 2004 |
Hecimovic S, Wang J, Dolios G, Martinez M, Wang R, Goate AM. Mutations in APP have independent effects on Abeta and CTFgamma generation. Neurobiology of Disease. 17: 205-18. PMID 15474359 DOI: 10.1016/J.Nbd.2004.04.018 |
0.365 |
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| 2004 |
Pastor P, Ezquerra M, Perez JC, Chakraverty S, Norton J, Racette BA, McKeel D, Perlmutter JS, Tolosa E, Goate AM. Novel haplotypes in 17q21 are associated with progressive supranuclear palsy. Annals of Neurology. 56: 249-58. PMID 15293277 DOI: 10.1002/Ana.20178 |
0.729 |
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