Isabella A. Graef - Publications

Affiliations: 
Stanford University, Palo Alto, CA 
Area:
Developmental Neuroscience

22/42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2018 Priya R, Paredes MF, Karayannis T, Yusuf N, Liu X, Jaglin X, Graef I, Alvarez-Buylla A, Fishell G. Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism. Cell Reports. 22: 1695-1709. PMID 29444424 DOI: 10.1016/J.Celrep.2018.01.007  0.31
2016 Perez-Branguli F, Zagar Y, Shanley DK, Graef IA, Chédotal A, Mitchell KJ. Reverse Signaling by Semaphorin-6A Regulates Cellular Aggregation and Neuronal Morphology. Plos One. 11: e0158686. PMID 27392094 DOI: 10.1371/Journal.Pone.0158686  0.367
2014 Cho A, Tang Y, Davila J, Deng S, Chen L, Miller E, Wernig M, Graef IA. Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. Neuron. 82: 109-24. PMID 24698271 DOI: 10.1016/J.Neuron.2014.02.015  0.379
2009 Kao SC, Wu H, Xie J, Chang CP, Ranish JA, Graef IA, Crabtree GR. Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science (New York, N.Y.). 323: 651-4. PMID 19179536 DOI: 10.1126/Science.1166562  0.378
2007 Wu JI, Lessard J, Olave IA, Qiu Z, Ghosh A, Graef IA, Crabtree GR. Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron. 56: 94-108. PMID 17920018 DOI: 10.1016/J.Neuron.2007.08.021  0.343
2007 Wu H, Peisley A, Graef IA, Crabtree GR. NFAT signaling and the invention of vertebrates. Trends in Cell Biology. 17: 251-60. PMID 17493814 DOI: 10.1016/J.Tcb.2007.04.006  0.354
2007 Zhou X, Babu JR, da Silva S, Shu Q, Graef IA, Oliver T, Tomoda T, Tani T, Wooten MW, Wang F. Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. Proceedings of the National Academy of Sciences of the United States of America. 104: 5842-7. PMID 17389358 DOI: 10.1073/Pnas.0701402104  0.306
2006 Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 441: 595-600. PMID 16554754 DOI: 10.1038/Nature04678  0.302
2005 Bose M, Gestwicki JE, Devasthali V, Crabtree GR, Graef IA. 'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation. Biochemical Society Transactions. 33: 543-7. PMID 16042540 DOI: 10.1042/Bst0330543  0.323
2005 Yang TT, Xiong Q, Graef IA, Crabtree GR, Chow CW. Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complex. Molecular and Cellular Biology. 25: 907-20. PMID 15657420 DOI: 10.1128/Mcb.25.3.907-920.2005  0.377
2003 Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 113: 657-70. PMID 12787506 DOI: 10.1016/S0092-8674(03)00390-8  0.314
2001 Graef IA, Chen F, Crabtree GR. NFAT signaling in vertebrate development. Current Opinion in Genetics & Development. 11: 505-12. PMID 11532391 DOI: 10.1016/S0959-437X(00)00225-2  0.378
2001 Graef IA, Chen F, Chen L, Kuo A, Crabtree GR. Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 105: 863-75. PMID 11439183 DOI: 10.1016/S0092-8674(01)00396-8  0.331
2001 Graef IA, Gastier JM, Francke U, Crabtree GR. Evolutionary relationships among Rel domains indicate functional diversification by recombination. Proceedings of the National Academy of Sciences of the United States of America. 98: 5740-5. PMID 11344309 DOI: 10.1073/Pnas.101602398  0.302
2001 Behrens A, Sabapathy K, Graef I, Cleary M, Crabtree GR, Wagner EF. Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT). Proceedings of the National Academy of Sciences of the United States of America. 98: 1769-74. PMID 11172026 DOI: 10.1073/Pnas.98.4.1769  0.334
2001 Sabapathy K, Kallunki T, David JP, Graef I, Karin M, Wagner EF. c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation. The Journal of Experimental Medicine. 193: 317-28. PMID 11157052 DOI: 10.1084/Jem.193.3.317  0.307
1999 Stankunas K, Graef IA, Neilson JR, Park SH, Crabtree GR. Signaling through calcium, calcineurin, and NF-AT in lymphocyte activation and development. Cold Spring Harbor Symposia On Quantitative Biology. 64: 505-16. PMID 11232327 DOI: 10.1101/Sqb.1999.64.505  0.305
1999 Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW, Crabtree GR. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature. 401: 703-8. PMID 10537109 DOI: 10.1038/44378  0.326
1998 Holsinger LJ, Graef IA, Swat W, Chi T, Bautista DM, Davidson L, Lewis RS, Alt FW, Crabtree GR. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Current Biology : Cb. 8: 563-72. PMID 9601640 DOI: 10.1016/S0960-9822(98)70225-8  0.395
1997 Graef IA, Holsinger LJ, Diver S, Schreiber SL, Crabtree GR. Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. The Embo Journal. 16: 5618-28. PMID 9312021 DOI: 10.1093/Emboj/16.18.5618  0.349
1996 Ho S, Clipstone N, Timmermann L, Northrop J, Graef I, Fiorentino D, Nourse J, Crabtree GR. The mechanism of action of cyclosporin A and FK506. Clinical Immunology and Immunopathology. 80: S40-5. PMID 8811062 DOI: 10.1006/Clin.1996.0140  0.357
1995 Spencer DM, Graef I, Austin DJ, Schreiber SL, Crabtree GR. A general strategy for producing conditional alleles of Src-like tyrosine kinases. Proceedings of the National Academy of Sciences of the United States of America. 92: 9805-9. PMID 7568222 DOI: 10.1073/Pnas.92.21.9805  0.348
Low-probability matches (unlikely to be authored by this person)
2011 Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA. Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Science Translational Medicine. 3: 97ra81. PMID 21865539 DOI: 10.1126/Scitranslmed.3002473  0.3
2004 Gestwicki JE, Crabtree GR, Graef IA. Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation. Science (New York, N.Y.). 306: 865-9. PMID 15514157 DOI: 10.1126/Science.1101262  0.288
2008 Crabtree GR, Graef IA. Bursting into the nucleus. Science Signaling. 1: pe54. PMID 19109237 DOI: 10.1126/Scisignal.151Pe54  0.287
2007 Lessard J, Wu JI, Ranish JA, Wan M, Winslow MM, Staahl BT, Wu H, Aebersold R, Graef IA, Crabtree GR. An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron. 55: 201-15. PMID 17640523 DOI: 10.1016/J.Neuron.2007.06.019  0.285
2013 Penchala SC, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, ... Graef IA, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proceedings of the National Academy of Sciences of the United States of America. 110: 9992-7. PMID 23716704 DOI: 10.1073/Pnas.1300761110  0.284
1997 Graef IA, Crabtree GR. The transcriptional paradox: octamer factors and B and T cells. Science (New York, N.Y.). 277: 193-4. PMID 9235633 DOI: 10.1126/Science.277.5323.193  0.281
2009 Graef I, Alhamadsheh MM, Esteras-Chopo A, Branson K, Bose M, Pande V. Breaking protein-protein interactions: A combined chemical and computational approach to develop a new class of protein aggregation inhibitors Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.04.966  0.279
2004 Chang CP, Neilson JR, Bayle JH, Gestwicki JE, Kuo A, Stankunas K, Graef IA, Crabtree GR. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell. 118: 649-63. PMID 15339668 DOI: 10.1016/J.Cell.2004.08.010  0.279
2012 Novick PA, Lopes DH, Branson KM, Esteras-Chopo A, Graef IA, Bitan G, Pande VS. Design of β-amyloid aggregation inhibitors from a predicted structural motif. Journal of Medicinal Chemistry. 55: 3002-10. PMID 22420626 DOI: 10.1021/Jm201332P  0.271
2015 Arendt KL, Zhang Z, Ganesan S, Hintze M, Shin MM, Tang Y, Cho A, Graef IA, Chen L. Calcineurin mediates homeostatic synaptic plasticity by regulating retinoic acid synthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26443861 DOI: 10.1073/Pnas.1510239112  0.269
2006 Yang TT, Suk HY, Yang X, Olabisi O, Yu RY, Durand J, Jelicks LA, Kim JY, Scherer PE, Wang Y, Feng Y, Rossetti L, Graef IA, Crabtree GR, Chow CW. Role of transcription factor NFAT in glucose and insulin homeostasis. Molecular and Cellular Biology. 26: 7372-87. PMID 16908540 DOI: 10.1128/Mcb.00580-06  0.267
2018 Miller M, Pal A, Albusairi W, Joo H, Pappas B, Haque Tuhin MT, Liang D, Jampala R, Liu F, Khan J, Faaij M, Park M, Chan W, Graef I, Zamboni R, et al. Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. Journal of Medicinal Chemistry. PMID 30133284 DOI: 10.1021/Acs.Jmedchem.8B00817  0.255
2011 Esteras-Chopo A, Deng S, Graef I. A quantitative cellular sensor of protein aggregation Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1332  0.239
2004 Gestwicki JE, Crabtree GR, Graef IA. O2-03-02 A strategy for using bifunctional drugs to inhibit amyloid aggregation Neurobiology of Aging. 25: S36. DOI: 10.1016/S0197-4580(04)80120-9  0.235
2017 Alhamadsheh M, Miller M, Pal A, Albusairi W, Graef I, Sinha U, Fox J, Zamboni R, Kumar N. P5846AG10, an orally available, novel transthyretin (TTR) stabilizer: integrated preclinical evaluation predicts a highly effective treatment for TTR amyloid cardiomyopathy European Heart Journal. 38. DOI: 10.1093/Eurheartj/Ehx493.P5846  0.231
2006 Polleri A, Graef IA, Arron JR, Winslow MM, Kim SK, Miyakawa T, Francke U, Crabtree GR. Increased dosage of DSCR1 and DYRK1A on chromosome 21 destabilizes NFAT regulation and accounts for Down syndrome phenotypes Developmental Biology. 295: 324. DOI: 10.1016/J.Ydbio.2006.04.007  0.222
2022 Hagihara H, Shoji H, Kuroiwa M, Graef IA, Crabtree GR, Nishi A, Miyakawa T. Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice. Molecular Brain. 15: 94. PMID 36414974 DOI: 10.1186/s13041-022-00981-0  0.206
2017 Hagihara H, Catts VS, Katayama Y, Shoji H, Takagi T, Huang FL, Nakao A, Mori Y, Huang KP, Ishii S, Graef IA, Nakayama KI, Shannon Weickert C, Miyakawa T. Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28776581 DOI: 10.1038/Npp.2017.167  0.189
2006 Graef IA, Crabtree GR, Wang F. Calcineurin/NFAT Signaling in Development and Function of the Nervous System Transcription Factors in the Nervous System: Development, Brain Function, and Diseases. 353-378. DOI: 10.1002/3527608036.ch17  0.179
2024 Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, ... ... Graef IA, et al. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. Elife. 12. PMID 38529532 DOI: 10.7554/eLife.89376  0.078
Hide low-probability matches.