Year |
Citation |
Score |
2018 |
Priya R, Paredes MF, Karayannis T, Yusuf N, Liu X, Jaglin X, Graef I, Alvarez-Buylla A, Fishell G. Activity Regulates Cell Death within Cortical Interneurons through a Calcineurin-Dependent Mechanism. Cell Reports. 22: 1695-1709. PMID 29444424 DOI: 10.1016/J.Celrep.2018.01.007 |
0.31 |
|
2016 |
Perez-Branguli F, Zagar Y, Shanley DK, Graef IA, Chédotal A, Mitchell KJ. Reverse Signaling by Semaphorin-6A Regulates Cellular Aggregation and Neuronal Morphology. Plos One. 11: e0158686. PMID 27392094 DOI: 10.1371/Journal.Pone.0158686 |
0.367 |
|
2014 |
Cho A, Tang Y, Davila J, Deng S, Chen L, Miller E, Wernig M, Graef IA. Calcineurin signaling regulates neural induction through antagonizing the BMP pathway. Neuron. 82: 109-24. PMID 24698271 DOI: 10.1016/J.Neuron.2014.02.015 |
0.379 |
|
2009 |
Kao SC, Wu H, Xie J, Chang CP, Ranish JA, Graef IA, Crabtree GR. Calcineurin/NFAT signaling is required for neuregulin-regulated Schwann cell differentiation. Science (New York, N.Y.). 323: 651-4. PMID 19179536 DOI: 10.1126/Science.1166562 |
0.378 |
|
2007 |
Wu JI, Lessard J, Olave IA, Qiu Z, Ghosh A, Graef IA, Crabtree GR. Regulation of dendritic development by neuron-specific chromatin remodeling complexes. Neuron. 56: 94-108. PMID 17920018 DOI: 10.1016/J.Neuron.2007.08.021 |
0.343 |
|
2007 |
Wu H, Peisley A, Graef IA, Crabtree GR. NFAT signaling and the invention of vertebrates. Trends in Cell Biology. 17: 251-60. PMID 17493814 DOI: 10.1016/J.Tcb.2007.04.006 |
0.354 |
|
2007 |
Zhou X, Babu JR, da Silva S, Shu Q, Graef IA, Oliver T, Tomoda T, Tani T, Wooten MW, Wang F. Unc-51-like kinase 1/2-mediated endocytic processes regulate filopodia extension and branching of sensory axons. Proceedings of the National Academy of Sciences of the United States of America. 104: 5842-7. PMID 17389358 DOI: 10.1073/Pnas.0701402104 |
0.306 |
|
2006 |
Arron JR, Winslow MM, Polleri A, Chang CP, Wu H, Gao X, Neilson JR, Chen L, Heit JJ, Kim SK, Yamasaki N, Miyakawa T, Francke U, Graef IA, Crabtree GR. NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 441: 595-600. PMID 16554754 DOI: 10.1038/Nature04678 |
0.302 |
|
2005 |
Bose M, Gestwicki JE, Devasthali V, Crabtree GR, Graef IA. 'Nature-inspired' drug-protein complexes as inhibitors of Abeta aggregation. Biochemical Society Transactions. 33: 543-7. PMID 16042540 DOI: 10.1042/Bst0330543 |
0.323 |
|
2005 |
Yang TT, Xiong Q, Graef IA, Crabtree GR, Chow CW. Recruitment of the extracellular signal-regulated kinase/ribosomal S6 kinase signaling pathway to the NFATc4 transcription activation complex. Molecular and Cellular Biology. 25: 907-20. PMID 15657420 DOI: 10.1128/Mcb.25.3.907-920.2005 |
0.377 |
|
2003 |
Graef IA, Wang F, Charron F, Chen L, Neilson J, Tessier-Lavigne M, Crabtree GR. Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. Cell. 113: 657-70. PMID 12787506 DOI: 10.1016/S0092-8674(03)00390-8 |
0.314 |
|
2001 |
Graef IA, Chen F, Crabtree GR. NFAT signaling in vertebrate development. Current Opinion in Genetics & Development. 11: 505-12. PMID 11532391 DOI: 10.1016/S0959-437X(00)00225-2 |
0.378 |
|
2001 |
Graef IA, Chen F, Chen L, Kuo A, Crabtree GR. Signals transduced by Ca(2+)/calcineurin and NFATc3/c4 pattern the developing vasculature. Cell. 105: 863-75. PMID 11439183 DOI: 10.1016/S0092-8674(01)00396-8 |
0.331 |
|
2001 |
Graef IA, Gastier JM, Francke U, Crabtree GR. Evolutionary relationships among Rel domains indicate functional diversification by recombination. Proceedings of the National Academy of Sciences of the United States of America. 98: 5740-5. PMID 11344309 DOI: 10.1073/Pnas.101602398 |
0.302 |
|
2001 |
Behrens A, Sabapathy K, Graef I, Cleary M, Crabtree GR, Wagner EF. Jun N-terminal kinase 2 modulates thymocyte apoptosis and T cell activation through c-Jun and nuclear factor of activated T cell (NF-AT). Proceedings of the National Academy of Sciences of the United States of America. 98: 1769-74. PMID 11172026 DOI: 10.1073/Pnas.98.4.1769 |
0.334 |
|
2001 |
Sabapathy K, Kallunki T, David JP, Graef I, Karin M, Wagner EF. c-Jun NH2-terminal kinase (JNK)1 and JNK2 have similar and stage-dependent roles in regulating T cell apoptosis and proliferation. The Journal of Experimental Medicine. 193: 317-28. PMID 11157052 DOI: 10.1084/Jem.193.3.317 |
0.307 |
|
1999 |
Stankunas K, Graef IA, Neilson JR, Park SH, Crabtree GR. Signaling through calcium, calcineurin, and NF-AT in lymphocyte activation and development. Cold Spring Harbor Symposia On Quantitative Biology. 64: 505-16. PMID 11232327 DOI: 10.1101/Sqb.1999.64.505 |
0.305 |
|
1999 |
Graef IA, Mermelstein PG, Stankunas K, Neilson JR, Deisseroth K, Tsien RW, Crabtree GR. L-type calcium channels and GSK-3 regulate the activity of NF-ATc4 in hippocampal neurons. Nature. 401: 703-8. PMID 10537109 DOI: 10.1038/44378 |
0.326 |
|
1998 |
Holsinger LJ, Graef IA, Swat W, Chi T, Bautista DM, Davidson L, Lewis RS, Alt FW, Crabtree GR. Defects in actin-cap formation in Vav-deficient mice implicate an actin requirement for lymphocyte signal transduction. Current Biology : Cb. 8: 563-72. PMID 9601640 DOI: 10.1016/S0960-9822(98)70225-8 |
0.395 |
|
1997 |
Graef IA, Holsinger LJ, Diver S, Schreiber SL, Crabtree GR. Proximity and orientation underlie signaling by the non-receptor tyrosine kinase ZAP70. The Embo Journal. 16: 5618-28. PMID 9312021 DOI: 10.1093/Emboj/16.18.5618 |
0.349 |
|
1996 |
Ho S, Clipstone N, Timmermann L, Northrop J, Graef I, Fiorentino D, Nourse J, Crabtree GR. The mechanism of action of cyclosporin A and FK506. Clinical Immunology and Immunopathology. 80: S40-5. PMID 8811062 DOI: 10.1006/Clin.1996.0140 |
0.357 |
|
1995 |
Spencer DM, Graef I, Austin DJ, Schreiber SL, Crabtree GR. A general strategy for producing conditional alleles of Src-like tyrosine kinases. Proceedings of the National Academy of Sciences of the United States of America. 92: 9805-9. PMID 7568222 DOI: 10.1073/Pnas.92.21.9805 |
0.348 |
|
Low-probability matches (unlikely to be authored by this person) |
2011 |
Alhamadsheh MM, Connelly S, Cho A, Reixach N, Powers ET, Pan DW, Wilson IA, Kelly JW, Graef IA. Potent kinetic stabilizers that prevent transthyretin-mediated cardiomyocyte proteotoxicity. Science Translational Medicine. 3: 97ra81. PMID 21865539 DOI: 10.1126/Scitranslmed.3002473 |
0.3 |
|
2004 |
Gestwicki JE, Crabtree GR, Graef IA. Harnessing chaperones to generate small-molecule inhibitors of amyloid beta aggregation. Science (New York, N.Y.). 306: 865-9. PMID 15514157 DOI: 10.1126/Science.1101262 |
0.288 |
|
2008 |
Crabtree GR, Graef IA. Bursting into the nucleus. Science Signaling. 1: pe54. PMID 19109237 DOI: 10.1126/Scisignal.151Pe54 |
0.287 |
|
2007 |
Lessard J, Wu JI, Ranish JA, Wan M, Winslow MM, Staahl BT, Wu H, Aebersold R, Graef IA, Crabtree GR. An essential switch in subunit composition of a chromatin remodeling complex during neural development. Neuron. 55: 201-15. PMID 17640523 DOI: 10.1016/J.Neuron.2007.06.019 |
0.285 |
|
2013 |
Penchala SC, Connelly S, Wang Y, Park MS, Zhao L, Baranczak A, Rappley I, Vogel H, Liedtke M, Witteles RM, Powers ET, Reixach N, Chan WK, Wilson IA, Kelly JW, ... Graef IA, et al. AG10 inhibits amyloidogenesis and cellular toxicity of the familial amyloid cardiomyopathy-associated V122I transthyretin. Proceedings of the National Academy of Sciences of the United States of America. 110: 9992-7. PMID 23716704 DOI: 10.1073/Pnas.1300761110 |
0.284 |
|
1997 |
Graef IA, Crabtree GR. The transcriptional paradox: octamer factors and B and T cells. Science (New York, N.Y.). 277: 193-4. PMID 9235633 DOI: 10.1126/Science.277.5323.193 |
0.281 |
|
2009 |
Graef I, Alhamadsheh MM, Esteras-Chopo A, Branson K, Bose M, Pande V. Breaking protein-protein interactions: A combined chemical and computational approach to develop a new class of protein aggregation inhibitors Alzheimers & Dementia. 5. DOI: 10.1016/J.Jalz.2009.04.966 |
0.279 |
|
2004 |
Chang CP, Neilson JR, Bayle JH, Gestwicki JE, Kuo A, Stankunas K, Graef IA, Crabtree GR. A field of myocardial-endocardial NFAT signaling underlies heart valve morphogenesis. Cell. 118: 649-63. PMID 15339668 DOI: 10.1016/J.Cell.2004.08.010 |
0.279 |
|
2012 |
Novick PA, Lopes DH, Branson KM, Esteras-Chopo A, Graef IA, Bitan G, Pande VS. Design of β-amyloid aggregation inhibitors from a predicted structural motif. Journal of Medicinal Chemistry. 55: 3002-10. PMID 22420626 DOI: 10.1021/Jm201332P |
0.271 |
|
2015 |
Arendt KL, Zhang Z, Ganesan S, Hintze M, Shin MM, Tang Y, Cho A, Graef IA, Chen L. Calcineurin mediates homeostatic synaptic plasticity by regulating retinoic acid synthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 26443861 DOI: 10.1073/Pnas.1510239112 |
0.269 |
|
2006 |
Yang TT, Suk HY, Yang X, Olabisi O, Yu RY, Durand J, Jelicks LA, Kim JY, Scherer PE, Wang Y, Feng Y, Rossetti L, Graef IA, Crabtree GR, Chow CW. Role of transcription factor NFAT in glucose and insulin homeostasis. Molecular and Cellular Biology. 26: 7372-87. PMID 16908540 DOI: 10.1128/Mcb.00580-06 |
0.267 |
|
2018 |
Miller M, Pal A, Albusairi W, Joo H, Pappas B, Haque Tuhin MT, Liang D, Jampala R, Liu F, Khan J, Faaij M, Park M, Chan W, Graef I, Zamboni R, et al. Enthalpy-Driven Stabilization of Transthyretin by AG10 Mimics a Naturally Occurring Genetic Variant That Protects from Transthyretin Amyloidosis. Journal of Medicinal Chemistry. PMID 30133284 DOI: 10.1021/Acs.Jmedchem.8B00817 |
0.255 |
|
2011 |
Esteras-Chopo A, Deng S, Graef I. A quantitative cellular sensor of protein aggregation Alzheimers & Dementia. 7. DOI: 10.1016/J.Jalz.2011.05.1332 |
0.239 |
|
2004 |
Gestwicki JE, Crabtree GR, Graef IA. O2-03-02 A strategy for using bifunctional drugs to inhibit amyloid aggregation Neurobiology of Aging. 25: S36. DOI: 10.1016/S0197-4580(04)80120-9 |
0.235 |
|
2017 |
Alhamadsheh M, Miller M, Pal A, Albusairi W, Graef I, Sinha U, Fox J, Zamboni R, Kumar N. P5846AG10, an orally available, novel transthyretin (TTR) stabilizer: integrated preclinical evaluation predicts a highly effective treatment for TTR amyloid cardiomyopathy European Heart Journal. 38. DOI: 10.1093/Eurheartj/Ehx493.P5846 |
0.231 |
|
2006 |
Polleri A, Graef IA, Arron JR, Winslow MM, Kim SK, Miyakawa T, Francke U, Crabtree GR. Increased dosage of DSCR1 and DYRK1A on chromosome 21 destabilizes NFAT regulation and accounts for Down syndrome phenotypes Developmental Biology. 295: 324. DOI: 10.1016/J.Ydbio.2006.04.007 |
0.222 |
|
2022 |
Hagihara H, Shoji H, Kuroiwa M, Graef IA, Crabtree GR, Nishi A, Miyakawa T. Forebrain-specific conditional calcineurin deficiency induces dentate gyrus immaturity and hyper-dopaminergic signaling in mice. Molecular Brain. 15: 94. PMID 36414974 DOI: 10.1186/s13041-022-00981-0 |
0.206 |
|
2017 |
Hagihara H, Catts VS, Katayama Y, Shoji H, Takagi T, Huang FL, Nakao A, Mori Y, Huang KP, Ishii S, Graef IA, Nakayama KI, Shannon Weickert C, Miyakawa T. Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28776581 DOI: 10.1038/Npp.2017.167 |
0.189 |
|
2006 |
Graef IA, Crabtree GR, Wang F. Calcineurin/NFAT Signaling in Development and Function of the Nervous System Transcription Factors in the Nervous System: Development, Brain Function, and Diseases. 353-378. DOI: 10.1002/3527608036.ch17 |
0.179 |
|
2024 |
Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, ... ... Graef IA, et al. Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. Elife. 12. PMID 38529532 DOI: 10.7554/eLife.89376 |
0.078 |
|
Hide low-probability matches. |