| Year |
Citation |
Score |
| 2020 |
Kickinger S, Al-Khawaja A, Haugaard AS, Lie MEK, Bavo F, Löffler R, Damgaard M, Ecker GF, Frølund B, Wellendorph P. Exploring the molecular determinants for subtype-selectivity of 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylic acid analogs as betaine/GABA transporter 1 (BGT1) substrate-inhibitors. Scientific Reports. 10: 12992. PMID 32747622 DOI: 10.1038/S41598-020-69908-W |
0.372 |
|
| 2020 |
Colas C, Banci G, Martini R, Ecker GF. Studies of structural determinants of substrate binding in the Creatine Transporter (CreaT, SLC6A8) using molecular models. Scientific Reports. 10: 6241. PMID 32277128 DOI: 10.1038/S41598-020-63189-Z |
0.364 |
|
| 2020 |
Superti-Furga G, Lackner D, Wiedmer T, Ingles-Prieto A, Barbosa B, Girardi E, Goldmann U, Gürtl B, Klavins K, Klimek C, Lindinger S, Liñeiro-Retes E, Müller AC, Onstein S, Redinger G, ... ... Ecker G, et al. The RESOLUTE consortium: unlocking SLC transporters for drug discovery. Nature Reviews. Drug Discovery. PMID 32265506 DOI: 10.1038/D41573-020-00056-6 |
0.331 |
|
| 2020 |
Lie MEK, Kickinger S, Skovgaard-Petersen J, Ecker GF, Clausen RP, Schousboe A, White HS, Wellendorph P. Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects. Neurochemical Research. PMID 32248400 DOI: 10.1007/S11064-020-03017-Y |
0.315 |
|
| 2020 |
Girardi E, César-Razquin A, Lindinger S, Papakostas K, Konecka J, Hemmerich J, Kickinger S, Kartnig F, Gürtl B, Klavins K, Sedlyarov V, Ingles-Prieto A, Fiume G, Koren A, Lardeau CH, ... ... Ecker GF, et al. A widespread role for SLC transmembrane transporters in resistance to cytotoxic drugs. Nature Chemical Biology. PMID 32152546 DOI: 10.1038/S41589-020-0483-3 |
0.371 |
|
| 2020 |
Cseke A, Schwarz T, Jain S, Decker S, Vogl K, Urban E, Ecker GF. Propafenone analogue with additional H-bond acceptor group shows increased inhibitory activity on P-glycoprotein. Archiv Der Pharmazie. e1900269. PMID 31917466 DOI: 10.1002/Ardp.201900269 |
0.337 |
|
| 2020 |
Troger F, Delp J, Funke M, van der Stel W, Colas C, Leist M, van de Water B, Ecker GF. Identification of mitochondrial toxicants by combined in silico and in vitro studies – A structure-based view on the adverse outcome pathway Computational Toxicology. 14: 100123. DOI: 10.1016/J.Comtox.2020.100123 |
0.306 |
|
| 2019 |
Montanari F, Knasmüller B, Kohlbacher S, Hillisch C, Baierová C, Grandits M, Ecker GF. Vienna LiverTox Workspace-A Set of Machine Learning Models for Prediction of Interactions Profiles of Small Molecules With Transporters Relevant for Regulatory Agencies. Frontiers in Chemistry. 7: 899. PMID 31998690 DOI: 10.3389/Fchem.2019.00899 |
0.368 |
|
| 2019 |
Singh N, Villoutreix BO, Ecker GF. Rigorous sampling of docking poses unveils binding hypothesis for the halogenated ligands of L-type Amino acid Transporter 1 (LAT1). Scientific Reports. 9: 15061. PMID 31636293 DOI: 10.1038/S41598-019-51455-8 |
0.351 |
|
| 2019 |
Hellsberg E, Ecker GF, Stary-Weinzinger A, Forrest LR. A structural model of the human serotonin transporter in an outward-occluded state. Plos One. 14: e0217377. PMID 31251747 DOI: 10.1371/Journal.Pone.0217377 |
0.371 |
|
| 2019 |
Kickinger S, Hellsberg E, BenteFrølund, Schousboe A, Ecker GF, Wellendorph P. Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function. Neuropharmacology. PMID 31108110 DOI: 10.1016/J.Neuropharm.2019.05.021 |
0.305 |
|
| 2019 |
Niello M, Cintulova D, Hellsberg E, Jäntsch K, Holy M, Ayatollahi LH, Cozzi NV, Freissmuth M, Sandtner W, Ecker GF, Mihovilovic MD, Sitte HH. para-Trifluoromethyl-methcathinone is an allosteric modulator of the serotonin transporter. Neuropharmacology. PMID 31028773 DOI: 10.1016/J.Neuropharm.2019.04.021 |
0.351 |
|
| 2019 |
Jain S, Ecker GF. In Silico Approaches to Predict Drug-Transporter Interaction Profiles: Data Mining, Model Generation, and Link to Cholestasis. Methods in Molecular Biology (Clifton, N.J.). 1981: 383-396. PMID 31016669 DOI: 10.1007/978-1-4939-9420-5_26 |
0.376 |
|
| 2018 |
Singh N, Scalise M, Galluccio M, Wieder M, Seidel T, Langer T, Indiveri C, Ecker GF. Discovery of Potent Inhibitors for the Large Neutral Amino Acid Transporter 1 (LAT1) by Structure-Based Methods. International Journal of Molecular Sciences. 20. PMID 30577601 DOI: 10.3390/Ijms20010027 |
0.359 |
|
| 2018 |
Schuetz DA, Bernetti M, Bertazzo M, Musil D, Eggenweiler HM, Recanatini M, Masetti M, Ecker GF, Cavalli A. Predicting Residence Time And Drug Unbinding Pathway Through Scaled Molecular Dynamics. Journal of Chemical Information and Modeling. PMID 30500211 DOI: 10.1021/Acs.Jcim.8B00614 |
0.324 |
|
| 2018 |
Schuetz DA, Seidel T, Garon A, Martini R, Körbel M, Ecker GF, Langer T. GRAIL: GRids of phArmacophore Interaction fieLds. Journal of Chemical Theory and Computation. PMID 30075621 DOI: 10.1021/Acs.Jctc.8B00495 |
0.317 |
|
| 2018 |
Siebert DCB, Wieder M, Schlener L, Scholze P, Boresch S, Langer T, Schnürch M, Mihovilovic MD, Richter L, Ernst M, Ecker GF. SAR-Guided Scoring Function and Mutational Validation Reveal Binding Mode of CGS-8216 at the α1+/γ2- Benzodiazepine Site. Journal of Chemical Information and Modeling. PMID 30028134 DOI: 10.1021/Acs.Jcim.8B00199 |
0.347 |
|
| 2018 |
Jain S, Grandits M, Ecker GF. Interspecies comparison of putative ligand binding sites of human, rat and mouse P-glycoprotein. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. PMID 29936088 DOI: 10.1016/J.Ejps.2018.06.022 |
0.374 |
|
| 2018 |
Estrada-Tejedor R, Ecker GF. Predicting drug resistance related to ABC transporters using unsupervised Consensus Self-Organizing Maps. Scientific Reports. 8: 6803. PMID 29717183 DOI: 10.1038/S41598-018-25235-9 |
0.349 |
|
| 2018 |
Singh N, Ecker GF. Insights into the Structure, Function, and Ligand Discovery of the Large Neutral Amino Acid Transporter 1, LAT1. International Journal of Molecular Sciences. 19. PMID 29695141 DOI: 10.3390/Ijms19051278 |
0.374 |
|
| 2018 |
Jain S, Kotsampasakou E, Ecker GF. Comparing the performance of meta-classifiers-a case study on selected imbalanced data sets relevant for prediction of liver toxicity. Journal of Computer-Aided Molecular Design. PMID 29626291 DOI: 10.1007/S10822-018-0116-Z |
0.304 |
|
| 2017 |
Jørgensen L, Al-Khawaja A, Kickinger S, Vogensen SB, Skovgaard-Petersen J, Jensen ER, Borkar N, Löffler R, Madsen KK, Bräuner-Osborne H, Schousboe A, Ecker GF, Wellendorph P, Clausen RP. Structure-activity relationship, pharmacological characterization and molecular modeling of non-competitive inhibitors of the betaine/γ-aminobutyric acid transporter 1 (BGT1). Journal of Medicinal Chemistry. PMID 28991462 DOI: 10.1021/Acs.Jmedchem.7B00924 |
0.369 |
|
| 2017 |
Damgaard M, Haugaard AS, Kickinger S, Al-Khawaja A, Lie MEK, Ecker GF, Clausen RP, Frølund B. Development of Non-GAT1-Selective Inhibitors: Challenges and Achievements. Advances in Neurobiology. 16: 315-332. PMID 28828618 DOI: 10.1007/978-3-319-55769-4_16 |
0.317 |
|
| 2017 |
Kotsampasakou E, Montanari F, Ecker GF. Predicting drug-induced liver injury: the importance of data curation. Toxicology. PMID 28652195 DOI: 10.1016/J.Tox.2017.06.003 |
0.364 |
|
| 2017 |
Spork M, Sohail MI, Schmid D, Ecker GF, Freissmuth M, Chiba P, Stockner T. Folding correction of ABC-transporter ABCB1 by pharmacological chaperones: a mechanistic concept. Pharmacology Research & Perspectives. 5: e00325. PMID 28603639 DOI: 10.1002/Prp2.325 |
0.367 |
|
| 2017 |
Jain S, Grandits M, Richter L, Ecker GF. Structure based classification for bile salt export pump (BSEP) inhibitors using comparative structural modeling of human BSEP. Journal of Computer-Aided Molecular Design. PMID 28527154 DOI: 10.1007/S10822-017-0021-X |
0.389 |
|
| 2017 |
Schuetz DA, de Witte WEA, Wong YC, Knasmueller B, Richter L, Kokh DB, Sadiq SK, Bosma R, Nederpelt I, Segala E, Amaral M, Guo D, Andres D, Georgi V, Stoddart LA, ... ... Ecker GF, et al. Kinetics for Drug Discovery: an industry-driven effort to target drug residence time. Drug Discovery Today. PMID 28412474 DOI: 10.1016/J.Drudis.2017.02.002 |
0.337 |
|
| 2017 |
Kotsampasakou E, Escher SE, Ecker GF. Curated human hyperbilirubinemia data and the respective OATP1B1 and 1B3 inhibition predictions. Data in Brief. 11: 204-207. PMID 28243614 DOI: 10.1016/J.Dib.2017.02.009 |
0.312 |
|
| 2017 |
Kotsampasakou E, Ecker GF. Predicting Drug-Induced Cholestasis with the Help of Hepatic Transporters-An in Silico Modeling Approach. Journal of Chemical Information and Modeling. 57: 608-615. PMID 28166633 DOI: 10.1021/Acs.Jcim.6B00518 |
0.364 |
|
| 2017 |
Kotsampasakou E, Escher SE, Ecker GF. Linking organic anion transporting polypeptide 1B1 and 1B3 (OATP1B1 and OATP1B3) interaction profiles to hepatotoxicity - The hyperbilirubinemia use case. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 100: 9-16. PMID 28063966 DOI: 10.1016/J.Ejps.2017.01.002 |
0.304 |
|
| 2017 |
Goldmann D, Zdrazil B, Digles D, Ecker GF. Empowering pharmacoinformatics by linked life science data. Journal of Computer-Aided Molecular Design. 31: 319-328. PMID 27830428 DOI: 10.1007/S10822-016-9990-4 |
0.301 |
|
| 2016 |
Zdrazil B, Hellsberg E, Viereck M, Ecker GF. From linked open data to molecular interaction: studying selectivity trends for ligands of the human serotonin and dopamine transporter. Medchemcomm. 7: 1819-1831. PMID 27891211 DOI: 10.1039/C6Md00207B |
0.34 |
|
| 2016 |
Seddik A, Geerke DP, Stockner T, Holy M, Kudlacek O, Cozzi NV, Ruoho AE, Sitte HH, Ecker GF. Combined Simulation and Mutation Studies to Elucidate Selectivity of Unsubstituted Amphetamine-like Cathinones at the Dopamine Transporter. Molecular Informatics. PMID 27860344 DOI: 10.1002/Minf.201600094 |
0.342 |
|
| 2016 |
Montanari F, Cseke A, Wlcek K, Ecker GF. Virtual Screening of DrugBank Reveals Two Drugs as New BCRP Inhibitors. Journal of Biomolecular Screening. PMID 27401583 DOI: 10.1177/1087057116657513 |
0.37 |
|
| 2016 |
Puthenkalam R, Hieckel M, Simeone X, Suwattanasophon C, Feldbauer RV, Ecker GF, Ernst M. Structural Studies of GABAA Receptor Binding Sites: Which Experimental Structure Tells us What? Frontiers in Molecular Neuroscience. 9: 44. PMID 27378845 DOI: 10.3389/Fnmol.2016.00044 |
0.305 |
|
| 2016 |
Schwarz T, Montanari F, Cseke A, Wlcek K, Visvader L, Palme S, Chiba P, Kuchler K, Urban E, Ecker GF. Subtle Structural Differences Trigger Inhibitory Activity of Propafenone Analogues at the Two Polyspecific ABC Transporters: P-Glycoprotein (P-gp) and Breast Cancer Resistance Protein (BCRP). Chemmedchem. PMID 26970257 DOI: 10.1002/Cmdc.201500592 |
0.386 |
|
| 2016 |
Montanari F, Zdrazil B, Digles D, Ecker GF. Selectivity profiling of BCRP versus P-gp inhibition: from automated collection of polypharmacology data to multi-label learning. Journal of Cheminformatics. 8: 7. PMID 26855674 DOI: 10.1186/S13321-016-0121-Y |
0.352 |
|
| 2015 |
Sanz F, Carrió P, López O, Capoferri L, Kooi DP, Vermeulen NP, Geerke DP, Montanari F, Ecker GF, Schwab CH, Kleinöder T, Magdziarz T, Pastor M. Integrative Modeling Strategies for Predicting Drug Toxicities at the eTOX Project. Molecular Informatics. 34: 477-84. PMID 27490391 DOI: 10.1002/Minf.201400193 |
0.309 |
|
| 2015 |
Montanari F, Pinto M, Khunweeraphong N, Wlcek K, Sohail MI, Noeske T, Boyer S, Chiba P, Stieger B, Kuchler K, Ecker GF. Flagging drugs that inhibit the bile salt export pump. Molecular Pharmaceutics. PMID 26642869 DOI: 10.1021/Acs.Molpharmaceut.5B00594 |
0.37 |
|
| 2015 |
Sandtner W, Stockner T, Hasenhuetl PS, Partilla JS, Seddik A, Zhang Y, Cao J, Holy M, Steinkellner T, Rudnick G, Baumann MH, Ecker GF, Newman AH, Sitte HH. Binding Mode Selection Determines the Action of Ecstasy Homologs at Monoamine Transporters. Molecular Pharmacology. PMID 26519222 DOI: 10.1124/Mol.115.101394 |
0.347 |
|
| 2015 |
Venkatesan S, Saha K, Sohail A, Sandtner W, Freissmuth M, Ecker GF, Sitte HH, Stockner T. Refinement of the Central Steps of Substrate Transport by the Aspartate Transporter GltPh: Elucidating the Role of the Na2 Sodium Binding Site. Plos Computational Biology. 11: e1004551. PMID 26485255 DOI: 10.1371/Journal.Pcbi.1004551 |
0.326 |
|
| 2015 |
Kotsampasakou E, Brenner S, Jäger W, Ecker GF. Identification of Novel Inhibitors of Organic Anion Transporting Polypeptides 1B1 and 1B3 (OATP1B1 and OATP1B3) Using a Consensus Vote of Six Classification Models. Molecular Pharmaceutics. PMID 26469880 DOI: 10.1021/Acs.Molpharmaceut.5B00583 |
0.364 |
|
| 2015 |
Damgaard M, Al-Khawaja A, Vogensen SB, Jurik A, Sijm M, Lie ME, Bæk MI, Rosenthal E, Jensen AA, Ecker GF, Frølund B, Wellendorph P, Clausen RP. Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3. Acs Chemical Neuroscience. PMID 26154082 DOI: 10.1021/Acschemneuro.5B00150 |
0.334 |
|
| 2015 |
Hellsberg E, Montanari F, Ecker GF. The ABC of Phytohormone Translocation. Planta Medica. 81: 474-87. PMID 25905596 DOI: 10.1055/S-0035-1545880 |
0.339 |
|
| 2015 |
Vogensen SB, Jørgensen L, Madsen KK, Jurik A, Borkar N, Rosatelli E, Nielsen B, Ecker GF, Schousboe A, Clausen RP. Structure activity relationship of selective GABA uptake inhibitors. Bioorganic & Medicinal Chemistry. 23: 2480-8. PMID 25882526 DOI: 10.1016/J.Bmc.2015.03.060 |
0.338 |
|
| 2015 |
Montanari F, Ecker GF. Prediction of drug-ABC-transporter interaction - Recent advances and future challenges. Advanced Drug Delivery Reviews. 86: 17-26. PMID 25769815 DOI: 10.1016/J.Addr.2015.03.001 |
0.388 |
|
| 2015 |
Jurik A, Zdrazil B, Holy M, Stockner T, Sitte HH, Ecker GF. A binding mode hypothesis of tiagabine confirms liothyronine effect on γ-aminobutyric acid transporter 1 (GAT1). Journal of Medicinal Chemistry. 58: 2149-58. PMID 25679268 DOI: 10.1021/Jm5015428 |
0.392 |
|
| 2015 |
Neudorfer C, Seddik A, Shanab K, Jurik A, Rami-Mark C, Holzer W, Ecker G, Mitterhauser M, Wadsak W, Spreitzer H. Synthesis and in silico evaluation of novel compounds for PET-based investigations of the norepinephrine transporter. Molecules (Basel, Switzerland). 20: 1712-30. PMID 25608857 DOI: 10.3390/Molecules20011712 |
0.334 |
|
| 2015 |
Saha K, Partilla JS, Lehner KR, Seddik A, Stockner T, Holy M, Sandtner W, Ecker GF, Sitte HH, Baumann MH. 'Second-generation' mephedrone analogs, 4-MEC and 4-MePPP, differentially affect monoamine transporter function. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 40: 1321-31. PMID 25502630 DOI: 10.1038/Npp.2014.325 |
0.351 |
|
| 2015 |
Sitte HH, Venkatesan S, Sohail A, Saha K, Jayaraman K, Ecker GF, Freissmuth M, Sandtner W, Stockner T. Transporters in Motion: Combining Computational Approaches and LRET-Measurements Biophysical Journal. 108: 199a. DOI: 10.1016/J.Bpj.2014.11.1101 |
0.33 |
|
| 2014 |
Montanari F, Ecker GF. BCRP Inhibition: from Data Collection to Ligand-Based Modeling. Molecular Informatics. 33: 322-31. PMID 27485889 DOI: 10.1002/Minf.201400012 |
0.385 |
|
| 2014 |
Ratnam J, Zdrazil B, Digles D, Cuadrado-Rodriguez E, Neefs JM, Tipney H, Siebes R, Waagmeester A, Bradley G, Chau CH, Richter L, Brea J, Evelo CT, Jacoby E, Senger S, ... ... Ecker GF, et al. The application of the open pharmacological concepts triple store (open PHACTS) to support drug discovery research. Plos One. 9: e115460. PMID 25522365 DOI: 10.1371/Journal.Pone.0115460 |
0.316 |
|
| 2014 |
Michl J, Scharinger C, Zauner M, Kasper S, Freissmuth M, Sitte HH, Ecker GF, Pezawas L. A multivariate approach linking reported side effects of clinical antidepressant and antipsychotic trials to in vitro binding affinities. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. 24: 1463-74. PMID 25044049 DOI: 10.1016/J.Euroneuro.2014.06.013 |
0.319 |
|
| 2014 |
Pinto M, Digles D, Ecker GF. Computational models for predicting the interaction with ABC transporters. Drug Discovery Today. Technologies. 12: e69-77. PMID 25027377 DOI: 10.1016/J.Ddtec.2014.03.007 |
0.371 |
|
| 2014 |
Viereck M, Gaulton A, Digles D, Ecker GF. Transporter taxonomy - a comparison of different transport protein classification schemes. Drug Discovery Today. Technologies. 12: e37-46. PMID 25027374 DOI: 10.1016/J.Ddtec.2014.03.004 |
0.326 |
|
| 2014 |
Ecker GF. Transmembrane drug transporter - taxonomy, assays, and their role in drug discovery. Drug Discovery Today. Technologies. 12: e35-6. PMID 25027373 DOI: 10.1016/J.Ddtec.2014.04.002 |
0.321 |
|
| 2014 |
Carrió P, Pinto M, Ecker G, Sanz F, Pastor M. Applicability Domain ANalysis (ADAN): a robust method for assessing the reliability of drug property predictions. Journal of Chemical Information and Modeling. 54: 1500-11. PMID 24821140 DOI: 10.1021/Ci500172Z |
0.331 |
|
| 2014 |
Smith D, Artursson P, Avdeef A, Di L, Ecker GF, Faller B, Houston JB, Kansy M, Kerns EH, Krämer SD, Lennernäs H, van de Waterbeemd H, Sugano K, Testa B. Passive lipoidal diffusion and carrier-mediated cell uptake are both important mechanisms of membrane permeation in drug disposition. Molecular Pharmaceutics. 11: 1727-38. PMID 24724562 DOI: 10.1021/Mp400713V |
0.301 |
|
| 2014 |
Parveen Z, Brunhofer G, Jabeen I, Erker T, Chiba P, Ecker GF. Synthesis, biological evaluation and 3D-QSAR studies of new chalcone derivatives as inhibitors of human P-glycoprotein. Bioorganic & Medicinal Chemistry. 22: 2311-9. PMID 24613626 DOI: 10.1016/J.Bmc.2014.02.005 |
0.357 |
|
| 2014 |
Cakil YD, Khunweeraphong N, Parveen Z, Schmid D, Artaker M, Ecker GF, Sitte HH, Pusch O, Stockner T, Chiba P. Pore-exposed tyrosine residues of p-glycoprotein are important hydrogen-bonding partners for drugs Molecular Pharmacology. 85: 420-428. PMID 24366667 DOI: 10.1124/Mol.113.088526 |
0.356 |
|
| 2014 |
Klepsch F, Vasanthanathan P, Ecker GF. Ligand and structure-based classification models for prediction of P-glycoprotein inhibitors. Journal of Chemical Information and Modeling. 54: 218-29. PMID 24050383 DOI: 10.1021/Ci400289J |
0.383 |
|
| 2014 |
Venkatesan S, Sohail A, Saha K, Ecker G, Stockner T, Sandtner W, Sitte H. The Aspartate Transporter in Motion - Combining Steered Molecular Dynamics with Lanthanide Resonance Energy Transfer based Distance Measurements Biophysical Journal. 106: 366a. DOI: 10.1016/J.Bpj.2013.11.2077 |
0.324 |
|
| 2014 |
Sohail A, Kudlacek O, Daerr M, Stolt-Bergner P, Ecker G, Freissmuth M, Wanner K, Stockner T, Sandtner W, Sitte H. Unfolding the Structure of LeuT Employing Luminescence Resonance Energy Transfer Biophysical Journal. 106: 258a. DOI: 10.1016/J.Bpj.2013.11.1515 |
0.332 |
|
| 2013 |
Tsareva DA, Ecker GF. How Far Could We Go with Open Data - A Case Study for TRPV1 Antagonists. Molecular Informatics. 32: 555-562. PMID 23956804 DOI: 10.1002/Minf.201300019 |
0.334 |
|
| 2013 |
Jurik A, Reicherstorfer R, Zdrazil B, Ecker GF. Classification of High-Activity Tiagabine Analogs by Binary QSAR Modeling. Molecular Informatics. 32: 415-419. PMID 23956803 DOI: 10.1002/Minf.201300020 |
0.362 |
|
| 2013 |
Seddik A, Holy M, Weissensteiner R, Zdrazil B, Sitte HH, Ecker GF. Probing the Selectivity of Monoamine Transporter Substrates by Means of Molecular Modeling. Molecular Informatics. 32: 409-413. PMID 23956802 DOI: 10.1002/Minf.201300013 |
0.399 |
|
| 2013 |
Buchmayer F, Schicker K, Steinkellner T, Geier P, Stübiger G, Hamilton PJ, Jurik A, Stockner T, Yang JW, Montgomery T, Holy M, Hofmaier T, Kudlacek O, Matthies HJ, Ecker GF, et al. Amphetamine actions at the serotonin transporter rely on the availability of phosphatidylinositol-4,5-bisphosphate. Proceedings of the National Academy of Sciences of the United States of America. 110: 11642-7. PMID 23798435 DOI: 10.1073/Pnas.1220552110 |
0.334 |
|
| 2013 |
Varagic Z, Wimmer L, Schnürch M, Mihovilovic MD, Huang S, Rallapalli S, Cook JM, Mirheydari P, Ecker GF, Sieghart W, Ernst M. Identification of novel positive allosteric modulators and null modulators at the GABAA receptor α+β- interface. British Journal of Pharmacology. 169: 371-83. PMID 23472852 DOI: 10.1111/Bph.12151 |
0.317 |
|
| 2013 |
Stockner T, Montgomery TR, Kudlacek O, Weissensteiner R, Ecker GF, Freissmuth M, Sitte HH. Mutational analysis of the high-affinity zinc binding site validates a refined human dopamine transporter homology model. Plos Computational Biology. 9: e1002909. PMID 23436987 DOI: 10.1371/Journal.Pcbi.1002909 |
0.354 |
|
| 2013 |
Jabeen I, Wetwitayaklung P, Chiba P, Pastor M, Ecker GF. 2D- and 3D-QSAR studies of a series of benzopyranes and benzopyrano[3,4b][1,4]-oxazines as inhibitors of the multidrug transporter P-glycoprotein. Journal of Computer-Aided Molecular Design. 27: 161-71. PMID 23400406 DOI: 10.1007/S10822-013-9635-9 |
0.394 |
|
| 2013 |
Zdrazil B, Jurik A, Sitte HH, Ecker GF. Pairwise structural comparison of tiagabine analogs gives new insights into their protein binding modes Journal of Cheminformatics. 5. DOI: 10.1186/1758-2946-5-S1-P32 |
0.377 |
|
| 2012 |
Zdrazil B, Pinto M, Vasanthanathan P, Williams AJ, Balderud LZ, Engkvist O, Chichester C, Hersey A, Overington JP, Ecker GF. Annotating Human P-Glycoprotein Bioassay Data. Molecular Informatics. 31: 599-609. PMID 23293680 DOI: 10.1002/Minf.201200059 |
0.327 |
|
| 2012 |
Pinto M, Trauner M, Ecker GF. An In Silico Classification Model for Putative ABCC2 Substrates. Molecular Informatics. 31: 547-553. PMID 23198001 DOI: 10.1002/Minf.201200049 |
0.346 |
|
| 2012 |
Poongavanam V, Haider N, Ecker GF. Fingerprint-based in silico models for the prediction of P-glycoprotein substrates and inhibitors. Bioorganic & Medicinal Chemistry. 20: 5388-95. PMID 22595422 DOI: 10.1016/J.Bmc.2012.03.045 |
0.349 |
|
| 2012 |
Di L, Artursson P, Avdeef A, Ecker GF, Faller B, Fischer H, Houston JB, Kansy M, Kerns EH, Krämer SD, Lennernäs H, Sugano K. Evidence-based approach to assess passive diffusion and carrier-mediated drug transport. Drug Discovery Today. 17: 905-12. PMID 22507594 DOI: 10.1016/J.Drudis.2012.03.015 |
0.325 |
|
| 2012 |
Jabeen I, Pleban K, Rinner U, Chiba P, Ecker GF. Structure-activity relationships, ligand efficiency, and lipophilic efficiency profiles of benzophenone-type inhibitors of the multidrug transporter P-glycoprotein Journal of Medicinal Chemistry. 55: 3261-3273. PMID 22452412 DOI: 10.1021/Jm201705F |
0.373 |
|
| 2012 |
Richter L, de Graaf C, Sieghart W, Varagic Z, Mörzinger M, de Esch IJ, Ecker GF, Ernst M. Diazepam-bound GABAA receptor models identify new benzodiazepine binding-site ligands. Nature Chemical Biology. 8: 455-64. PMID 22446838 DOI: 10.1038/Nchembio.917 |
0.335 |
|
| 2012 |
Venkatesan S, Sohail A, Sandtner W, Stockner T, Ecker GF, Sitte HH. Deciphering structural rearrangements during transport process in the bacterial transporter GltPh, homolog to mammalian glutamate transporter Bmc Pharmacology and Toxicology. 13: A57. DOI: 10.1186/2050-6511-13-S1-A57 |
0.318 |
|
| 2012 |
Sohail A, Bulling S, Stolt-Bergner P, Kudlacek O, Ecker GF, Freissmuth M, Stockner T, Sitte HH, Sandtner W. Decrypting structural and functional changes in LeuTAa at atomic level employing LRET Bmc Pharmacology and Toxicology. 13: A53. DOI: 10.1186/2050-6511-13-S1-A53 |
0.311 |
|
| 2012 |
Zdrazil B, Jurik A, Reicherstorfer R, Stockner T, Sitte HH, Ecker GF. Insights into binding events of GABA- and Tiagabine- analogues in the Gamma-Aminobutyric Acid Transporter 1 by means of Molecular Modelling Journal of Cheminformatics. 4. DOI: 10.1186/1758-2946-4-S1-P54 |
0.346 |
|
| 2012 |
Pinto M, Ecker GF. A computational model for predicting the transport of compounds by ABCC2 Journal of Cheminformatics. 4. DOI: 10.1186/1758-2946-4-S1-P53 |
0.383 |
|
| 2011 |
Schwaha R, Ecker GF. Use of shape similarities for the classification of P-glycoprotein substrates and nonsubstrates. Future Medicinal Chemistry. 3: 1117-28. PMID 21806376 DOI: 10.4155/Fmc.11.58 |
0.344 |
|
| 2011 |
Klepsch F, Chiba P, Ecker GF. Exhaustive sampling of docking poses reveals binding hypotheses for propafenone type inhibitors of P-glycoprotein. Plos Computational Biology. 7: e1002036. PMID 21589945 DOI: 10.1371/Journal.Pcbi.1002036 |
0.371 |
|
| 2011 |
Parveen Z, Stockner T, Bentele C, Pferschy S, Kraupp M, Freissmuth M, Ecker GF, Chiba P. Molecular dissection of dual pseudosymmetric solute translocation pathways in human P-glycoprotein. Molecular Pharmacology. 79: 443-52. PMID 21177413 DOI: 10.1124/Mol.110.067611 |
0.367 |
|
| 2011 |
Jabeen I, Wetwitayaklung P, Klepsch F, Parveen Z, Chiba P, Ecker GF. Probing the stereoselectivity of P-glycoprotein-synthesis, biological activity and ligand docking studies of a set of enantiopure benzopyrano[3,4-b][1,4]oxazines. Chemical Communications (Cambridge, England). 47: 2586-8. PMID 21173990 DOI: 10.1039/C0Cc03075A |
0.348 |
|
| 2011 |
Brunhofer G, Studenik C, Ecker GF, Erker T. Synthesis, spasmolytic activity and structure-activity relationship study of a series of polypharmacological thiobenzanilides. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 42: 37-44. PMID 20969955 DOI: 10.1016/J.Ejps.2010.10.005 |
0.324 |
|
| 2011 |
Sohail A, Stolt-Bergner P, Ecker GF, Freissmuth M, Stockner T, Sitte HH, Sandtner W. LRET-based intramolecular distance measurements in LeuTAa Bmc Pharmacology. 11: A21. DOI: 10.1186/1471-2210-11-S2-A21 |
0.336 |
|
| 2010 |
Klepsch F, Ecker GF. Impact of the Recent Mouse P-Glycoprotein Structure for Structure-Based Ligand Design. Molecular Informatics. 29: 276-86. PMID 27463054 DOI: 10.1002/Minf.201000017 |
0.36 |
|
| 2010 |
Demel MA, Kraemer O, Ettmayer P, Haaksma E, Ecker GF. Ensemble Rule-Based Classification of Substrates of the Human ABC-Transporter ABCB1 Using Simple Physicochemical Descriptors. Molecular Informatics. 29: 233-42. PMID 27462766 DOI: 10.1002/Minf.200900079 |
0.388 |
|
| 2010 |
Sarker S, Weissensteiner R, Steiner I, Sitte HH, Ecker GF, Freissmuth M, Sucic S. The high-affinity binding site for tricyclic antidepressants resides in the outer vestibule of the serotonin transporter. Molecular Pharmacology. 78: 1026-35. PMID 20829432 DOI: 10.1124/Mol.110.067538 |
0.701 |
|
| 2010 |
Sugano K, Kansy M, Artursson P, Avdeef A, Bendels S, Di L, Ecker GF, Faller B, Fischer H, Gerebtzoff G, Lennernaes H, Senner F. Coexistence of passive and carrier-mediated processes in drug transport. Nature Reviews. Drug Discovery. 9: 597-614. PMID 20671764 DOI: 10.1038/Nrd3187 |
0.32 |
|
| 2010 |
Klepsch F, Stockner T, Erker T, Müller M, Chiba P, Ecker GF. Using structural and mechanistic information to design novel inhibitors/substrates of P-glycoprotein. Current Topics in Medicinal Chemistry. 10: 1769-74. PMID 20645918 DOI: 10.2174/156802610792928004 |
0.311 |
|
| 2010 |
Klepsch F, Jabeen I, Chiba P, Ecker GF. Pharmacoinformatic approaches to design natural product type ligands of ABC-transporters. Current Pharmaceutical Design. 16: 1742-52. PMID 20222855 DOI: 10.2174/138161210791163992 |
0.351 |
|
| 2010 |
Thai KM, Windisch A, Stork D, Weinzinger A, Schiesaro A, Guy RH, Timin EN, Hering S, Ecker GF. The hERG potassium channel and drug trapping: Insight from docking studies with propafenone derivatives Chemmedchem. 5: 436-442. PMID 20146282 DOI: 10.1002/Cmdc.200900374 |
0.303 |
|
| 2010 |
Sucic S, Dallinger S, Zdrazil B, Weissensteiner R, Jørgensen TN, Holy M, Kudlacek O, Seidel S, Cha JH, Gether U, Newman AH, Ecker GF, Freissmuth M, Sitte HH. The N terminus of monoamine transporters is a lever required for the action of amphetamines. The Journal of Biological Chemistry. 285: 10924-38. PMID 20118234 DOI: 10.1074/Jbc.M109.083154 |
0.322 |
|
| 2010 |
Sohail A, Stolt-Bergner P, Ecker GF, Freissmuth M, Sitte H, Sandtner W. Luminescence resonance energy transfer-based intramolecular distance measurements in leucine transporter from Aquifex aeolicus Bmc Pharmacology. 10. DOI: 10.1186/1471-2210-10-S1-A31 |
0.326 |
|
| 2010 |
Zdrazil B, Ecker GF. Cancer Drug Resistance: Targets and Therapies Burger's Medicinal Chemistry and Drug Discovery. 361-382. DOI: 10.1002/0471266949.Bmc215 |
0.301 |
|
| 2009 |
Demel MA, Krämer O, Ettmayer P, Haaksma EE, Ecker GF. Predicting ligand interactions with ABC transporters in ADME. Chemistry & Biodiversity. 6: 1960-9. PMID 19937827 DOI: 10.1002/Cbdv.200900138 |
0.401 |
|
| 2009 |
Thai KM, Ecker GF. Similarity-based SIBAR descriptors for classification of chemically diverse hERG blockers Molecular Diversity. 13: 321-336. PMID 19219559 DOI: 10.1007/S11030-009-9117-0 |
0.309 |
|
| 2009 |
Stockner T, de Vries SJ, Bonvin AM, Ecker GF, Chiba P. Data-driven homology modelling of P-glycoprotein in the ATP-bound state indicates flexibility of the transmembrane domains. The Febs Journal. 276: 964-72. PMID 19215299 DOI: 10.1111/J.1742-4658.2008.06832.X |
0.359 |
|
| 2009 |
Demel MA, Krämer O, Ettmayer P, Haaksma EEJ, Ecker GF. Identification of Privileged Atom-Types in Substrates of the ABC-Transporter ABCB1 (P-gp) by Random Forest Classification Scientia Pharmaceutica. 77: 187-187. DOI: 10.3797/Scipharm.Oephg.21.Sl-20 |
0.351 |
|
| 2009 |
Weissensteiner R, Sitte HH, Freissmuth M, Ecker GF. Docking of Multiple Ligands into a New Homology Model of the Serotonin Transporter Scientia Pharmaceutica. 77: 205-205. DOI: 10.3797/Scipharm.Oephg.21.Po-06 |
0.338 |
|
| 2009 |
Klepsch F, Chiba P, Stockner T, Ecker GF. Ligand Docking of Propafenones into a Homology Model of ABCB1 Scientia Pharmaceutica. 77: 204-204. DOI: 10.3797/Scipharm.Oephg.21.Po-05 |
0.347 |
|
| 2009 |
Jurik A, Weissensteiner R, Sarker S, Sitte HH, Freissmuth M, Ecker GF. Induced Fit Docking into a SERT Homology Model Scientia Pharmaceutica. 77: 203-203. DOI: 10.3797/Scipharm.Oephg.21.Po-04 |
0.347 |
|
| 2009 |
Jabeen I, Plagens B, Holzer W, Ecker GF. QSAR, HQSAR and GRIND Studies on a Set of Heterocyclic Propafenone-Type Inhibitors of P-Glycoprotein Scientia Pharmaceutica. 77: 201-201. DOI: 10.3797/Scipharm.Oephg.21.Po-02 |
0.355 |
|
| 2009 |
Schwaha R, Ecker G. Similarity Based Descriptors - Useful for Classification of Substrates of the Human Multidrug Transporter P-Glycoprotein? Qsar & Combinatorial Science. 28: 834-839. DOI: 10.1002/Qsar.200960051 |
0.377 |
|
| 2009 |
Demel M, Janecek A, Gansterer W, Ecker G. Comparison of Contemporary Feature Selection Algorithms: Application to the Classification of ABC-Transporter Substrates Qsar & Combinatorial Science. 28: 1087-1091. DOI: 10.1002/Qsar.200860191 |
0.333 |
|
| 2008 |
Thai KM, Ecker GF. Classification models for hERG inhibitors by counter-propagation neural networks Chemical Biology and Drug Design. 72: 279-289. PMID 18844674 DOI: 10.1111/J.1747-0285.2008.00705.X |
0.304 |
|
| 2008 |
Demel MA, Schwaha R, Krämer O, Ettmayer P, Haaksma EE, Ecker GF. In silico prediction of substrate properties for ABC-multidrug transporters. Expert Opinion On Drug Metabolism & Toxicology. 4: 1167-80. PMID 18721111 DOI: 10.1517/17425255.4.9.1167 |
0.388 |
|
| 2008 |
Ecker GF, Stockner T, Chiba P. Computational models for prediction of interactions with ABC-transporters. Drug Discovery Today. 13: 311-7. PMID 18405843 DOI: 10.1016/J.Drudis.2007.12.012 |
0.374 |
|
| 2008 |
Thai KM, Ecker GF. A binary QSAR model for classification of hERG potassium channel blockers Bioorganic and Medicinal Chemistry. 16: 4107-4119. PMID 18243713 DOI: 10.1016/J.Bmc.2008.01.017 |
0.328 |
|
| 2008 |
Ekins S, Ecker GF, Chiba P, Swaan PW. Future directions for drug transporter modelling. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 37: 1152-70. PMID 17968741 DOI: 10.1080/00498250701646341 |
0.402 |
|
| 2008 |
Demel MA, Janecek AGK, Thai KM, Ecker GF, Gansterer WN. Predictive QSAR models for polyspecific drug targets: The importance of feature selection Current Computer-Aided Drug Design. 4: 91-110. DOI: 10.2174/157340908784533256 |
0.343 |
|
| 2008 |
König G, Chiba P, Ecker GF. Hydrophobic moments as physicochemical descriptors in structure-activity relationship studies of P-glycoprotein inhibitors Monatshefte FüR Chemie - Chemical Monthly. 139: 401-405. DOI: 10.1007/S00706-007-0819-7 |
0.33 |
|
| 2007 |
Thai KM, Ecker GF. Predictive models for hERG channel blockers: Ligand-based and structure-based approaches Current Medicinal Chemistry. 14: 3003-3026. PMID 18220737 DOI: 10.2174/092986707782794087 |
0.322 |
|
| 2007 |
Clayton T, Chen JL, Ernst M, Richter L, Cromer BA, Morton CJ, Ng H, Kaczorowski CC, Helmstetter FJ, Furtmüller R, Ecker G, Parker MW, Sieghart W, Cook JM. An updated unified pharmacophore model of the benzodiazepine binding site on gamma-aminobutyric acid(a) receptors: correlation with comparative models. Current Medicinal Chemistry. 14: 2755-75. PMID 18045122 DOI: 10.2174/092986707782360097 |
0.323 |
|
| 2007 |
Cramer J, Kopp S, Bates SE, Chiba P, Ecker GF. Multispecificity of drug transporters: probing inhibitor selectivity for the human drug efflux transporters ABCB1 and ABCG2. Chemmedchem. 2: 1783-8. PMID 17994597 DOI: 10.1002/Cmdc.200700160 |
0.399 |
|
| 2007 |
Tasanor O, Ernst M, Thriemer K, Ecker GF, Noedl H, Chiba P. Characterization of a novel class of antimalarials and its applicability to plasmodial target identification. Wiener Klinische Wochenschrift. 119: 83-7. PMID 17987364 DOI: 10.1007/S00508-007-0864-6 |
0.348 |
|
| 2007 |
Zdrazil B, Kaiser D, Kopp S, Chiba P, Ecker G. Similarity-Based Descriptors (SIBAR) as Tool for QSAR Studies on P-Glycoprotein Inhibitors: Influence of the Reference Set Qsar & Combinatorial Science. 26: 669-678. DOI: 10.1002/Qsar.200610149 |
0.37 |
|
| 2006 |
Kaiser D, Smiesko M, Kopp S, Chiba P, Ecker GF. Interaction field based and hologram based QSAR analysis of propafenone-type modulators of multidrug resistance. Medicinal Chemistry (Shariqah (United Arab Emirates)). 1: 431-44. PMID 16787327 DOI: 10.2174/1573406054864061 |
0.359 |
|
| 2006 |
Chiba P, Mihalek I, Ecker GF, Kopp S, Lichtarge O. Role of transmembrane domain/transmembrane domain interfaces of P-glycoprotein (ABCB1) in solute transport. Convergent information from photoaffinity labeling, site directed mutagenesis and in silico importance prediction. Current Medicinal Chemistry. 13: 793-805. PMID 16611068 DOI: 10.2174/092986706776055607 |
0.386 |
|
| 2005 |
Kaiser D, Zdrazil B, Ecker GF. Similarity-based descriptors (SIBAR)--a tool for safe exchange of chemical information? Journal of Computer-Aided Molecular Design. 19: 687-92. PMID 16249834 DOI: 10.1007/S10822-005-9000-8 |
0.31 |
|
| 2005 |
Pleban K, Kaiser D, Kopp S, Peer M, Chiba P, Ecker GF. Targeting drug-efflux pumps -- a pharmacoinformatic approach. Acta Biochimica Polonica. 52: 737-40. PMID 16082413 DOI: 10.18388/Abp.2005_3439 |
0.336 |
|
| 2005 |
Pleban K, Ecker GF. Inhibitors of p-glycoprotein--lead identification and optimisation. Mini Reviews in Medicinal Chemistry. 5: 153-63. PMID 15720285 DOI: 10.2174/1389557053402729 |
0.333 |
|
| 2005 |
Pleban K, Kopp S, Csaszar E, Peer M, Hrebicek T, Rizzi A, Ecker GF, Chiba P. P-glycoprotein substrate binding domains are located at the transmembrane domain/transmembrane domain interfaces: a combined photoaffinity labeling-protein homology modeling approach. Molecular Pharmacology. 67: 365-74. PMID 15509712 DOI: 10.1124/Mol.104.006973 |
0.342 |
|
| 2004 |
Pleban K, Macchiarulo A, Costantino G, Pellicciari R, Chiba P, Ecker GF. Homology model of the multidrug transporter LmrA from Lactococcus lactis. Bioorganic & Medicinal Chemistry Letters. 14: 5823-6. PMID 15501048 DOI: 10.1016/J.Bmcl.2004.09.040 |
0.334 |
|
| 2004 |
Macchiarulo A, Costantino G, Meniconi M, Pleban K, Ecker G, Bellocchi D, Pellicciari R. Insights into phenylalanine derivatives recognition of VLA-4 integrin: from a pharmacophoric study to 3D-QSAR and molecular docking analyses. Journal of Chemical Information and Computer Sciences. 44: 1829-39. PMID 15446843 DOI: 10.1021/Ci049914L |
0.34 |
|
| 2004 |
Ecker GF, Pleban K, Kopp S, Csaszar E, Poelarends GJ, Putman M, Kaiser D, Konings WN, Chiba P. A three-dimensional model for the substrate binding domain of the multidrug ATP binding cassette transporter LmrA. Molecular Pharmacology. 66: 1169-79. PMID 15304548 DOI: 10.1124/Mol.104.001420 |
0.325 |
|
| 2004 |
Pleban K, Hoffer C, Kopp S, Peer M, Chiba P, Ecker GF. Intramolecular distribution of hydrophobicity influences pharmacological activity of propafenone-type MDR modulators Archiv Der Pharmazie. 337: 328-334. PMID 15188222 DOI: 10.1002/Ardp.200300862 |
0.305 |
|
| 2004 |
Langer T, Eder M, Hoffmann RD, Chiba P, Ecker GF. Lead identification for modulators of multidrug resistance based on in silico screening with a pharmacophoric feature model. Archiv Der Pharmazie. 337: 317-27. PMID 15188221 DOI: 10.1002/Ardp.200300817 |
0.361 |
|
| 2004 |
Ecker GF, Noe CR. In silico prediction models for blood-brain barrier permeation. Current Medicinal Chemistry. 11: 1617-28. PMID 15180567 DOI: 10.2174/0929867043365071 |
0.363 |
|
| 2004 |
Klein C, Kaiser D, Kopp S, Chiba P, Ecker GF. Similarity based SAR (SIBAR) as tool for early ADME profiling. Journal of Computer-Aided Molecular Design. 16: 785-93. PMID 12825790 DOI: 10.1023/A:1023828527638 |
0.383 |
|
| 2004 |
Chiba P, Ecker GF. Inhibitors of ABC-type drug efflux pumps: an overview of the current patent situation Expert Opinion On Therapeutic Patents. 14: 499-508. DOI: 10.1517/13543776.14.4.499 |
0.315 |
|
| 2004 |
Ecker GF, Chiba P. Development of modulators of multidrug resistance: A pharmacoinformatic approach Pure and Applied Chemistry. 76: 997-1005. DOI: 10.1351/Pac200476050997 |
0.321 |
|
| 2003 |
Schuetzer-Muehlbauer M, Willinger B, Egner R, Ecker G, Kuchler K. Reversal of antifungal resistance mediated by ABC efflux pumps from Candida albicans functionally expressed in yeast. International Journal of Antimicrobial Agents. 22: 291-300. PMID 13678837 DOI: 10.1016/S0924-8579(03)00213-9 |
0.321 |
|
| 2003 |
Rebitzer S, Annibali D, Kopp S, Eder M, Langer T, Chiba P, Ecker GF, Noe CR. In silico screening with benzofurane- and benzopyrane-type MDR-modulators. Farmaco (Società Chimica Italiana : 1989). 58: 185-91. PMID 12620414 DOI: 10.1016/S0014-827X(03)00021-1 |
0.351 |
|
| 2002 |
Chiba P, Erker T, Galanski M, Hitzler M, Ecker GF. Synthesis and multidrug-resistance modulating activity of a series of thienothiazines. Archiv Der Pharmazie. 335: 223-8. PMID 12210779 DOI: 10.1002/1521-4184(200205)335:5<223::Aid-Ardp223>3.0.Co;2-D |
0.321 |
|
| 2002 |
Ecker GF, Csaszar E, Kopp S, Plagens B, Holzer W, Ernst W, Chiba P. Identification of ligand-binding regions of P-glycoprotein by activated-pharmacophore photoaffinity labeling and matrix-assisted laser desorption/ionization-time-of-flight mass spectrometry. Molecular Pharmacology. 61: 637-48. PMID 11854445 DOI: 10.1124/Mol.61.3.637 |
0.363 |
|
| 2000 |
Buchstaller HP, Siebert CD, Lyssy RH, Ecker G, Krug M, Berger ML, Gottschlich R, Noe CR. Thieno[2,3-b]pyridinones as antagonists on the glycine site of the N- methyl-D-aspartate receptor - Binding studies, molecular modeling and structure-activity-relationships Scientia Pharmaceutica. 68: 3-14. DOI: 10.3797/Scipharm.Aut-00-01 |
0.316 |
|
| 1999 |
Schmid D, Ecker G, Kopp S, Hitzler M, Chiba P. Structure-activity relationship studies of propafenone analogs based on P-glycoprotein ATPase activity measurements. Biochemical Pharmacology. 58: 1447-56. PMID 10513988 DOI: 10.1016/S0006-2952(99)00229-4 |
0.322 |
|
| 1999 |
Hiessböck R, Wolf C, Richter E, Hitzler M, Chiba P, Kratzel M, Ecker G. Synthesis and in vitro multidrug resistance modulating activity of a series of dihydrobenzopyrans and tetrahydroquinolines. Journal of Medicinal Chemistry. 42: 1921-6. PMID 10354400 DOI: 10.1021/Jm980517+ |
0.322 |
|
| 1998 |
Tmej C, Chiba P, Huber M, Richter E, Hitzler M, Schaper KJ, Ecker G. A combined Hansch/Free-Wilson approach as predictive tool in QSAR studies on propafenone-type modulators of multidrug resistance. Archiv Der Pharmazie. 331: 233-40. PMID 9747179 DOI: 10.1002/(Sici)1521-4184(199807)331:7/8<233::Aid-Ardp233>3.0.Co;2-2 |
0.326 |
|
| 1998 |
Chiba P, Tell B, Jäger W, Richter E, Hitzler M, Ecker G. Studies on propafenone-type modulators of multidrug-resistance IV1): synthesis and pharmacological activity of 5-hydroxy and 5-benzyloxy derivatives. Archiv Der Pharmazie. 330: 343-7. PMID 9431026 DOI: 10.1002/Ardp.19973301105 |
0.303 |
|
| 1998 |
Chiba P, Annibali D, Hitzler M, Richter E, Ecker G. Studies on propafenone-type modulators of multidrug resistance VI. Synthesis and pharmacological activity of compounds with varied spacer length between the central aromatic ring and the nitrogen atom Il Farmaco. 53: 357-364. DOI: 10.1016/S0014-827X(98)00035-4 |
0.307 |
|
| 1997 |
Ecker G, Chiba P, Schaper KJ. Estimation of the chemosensitizing activity of modulators of multi-drug resistance via combined simultaneous analysis of sigmoidal dose-response curves. The Journal of Pharmacy and Pharmacology. 49: 305-9. PMID 9231351 DOI: 10.1111/J.2042-7158.1997.Tb06801.X |
0.307 |
|
| 1997 |
Chiba P, Hitzler M, Richter E, Huber M, Tmej C, Giovagnoni E, Ecker G. Studies on Propafenone-type Modulators of Multidrug Resistance III: Variations on the Nitrogen Quantitative Structure-Activity Relationships. 16: 361-366. DOI: 10.1002/Qsar.19970160502 |
0.322 |
|
| 1996 |
Ecker G, Chiba P, Hitzler M, Schmid D, Visser K, Cordes HP, Csöllei J, Seydel JK, Schaper KJ. Structure-activity relationship studies on benzofuran analogs of propafenone-type modulators of tumor cell multidrug resistance. Journal of Medicinal Chemistry. 39: 4767-74. PMID 8941391 DOI: 10.1021/Jm960384X |
0.313 |
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