| Year |
Citation |
Score |
| 2023 |
Kimishima A, Sakai K, Honsho M, Wasuwanich P, Matsui H, Watanabe Y, Iwatsuki M, Sunazuka T, Arima N, Abe K, Hanaki H, Asami Y. An efflux pump deletion mutant enabling the discovery of a macrolide as an overlooked anti-P. aeruginosa active compound. The Journal of Antibiotics. PMID 36964398 DOI: 10.1038/s41429-023-00607-0 |
0.754 |
|
| 2022 |
Kimishima A, Ando H, Sennari G, Noguchi Y, Sekikawa S, Kojima T, Ohara M, Watanabe Y, Inahashi Y, Takada H, Sugawara A, Matsumaru T, Iwatsuki M, Hirose T, Sunazuka T. Chemical Degradation-Inspired Total Synthesis of the Antibiotic Macrodiolide, Luminamicin. Journal of the American Chemical Society. PMID 36487183 DOI: 10.1021/jacs.2c10856 |
0.774 |
|
| 2022 |
Horikoshi R, Goto K, Mitomi M, Oyama K, Hirose T, Sunazuka T, Ōmura S. Afidopyropen, a novel insecticide originating from microbial secondary extracts. Scientific Reports. 12: 2827. PMID 35181691 DOI: 10.1038/s41598-022-06729-z |
0.403 |
|
| 2021 |
Sakai K, Iwatsuki M, Kaneta T, Kimishima A, Asami Y, Sunazuka T, Masuma R, Nonaka K. Sesquicillin F, a new insecticidal meroterpenoid produced by Mariannaea macrochlamydospora FKI-4735. The Journal of Antibiotics. PMID 34334788 DOI: 10.1038/s41429-021-00456-9 |
0.74 |
|
| 2021 |
Saito R, Sennari G, Nakajima A, Kimishima A, Iwatsuki M, Ishiyama A, Hokari R, Hirose T, Sunazuka T. Discoveries and Syntheses of Highly Potent Antimalarial Troponoids. Chemical & Pharmaceutical Bulletin. 69: 564-572. PMID 34078803 DOI: 10.1248/cpb.c21-00132 |
0.772 |
|
| 2021 |
Kanaida M, Kimishima A, Eguchi S, Iwatsuki M, Watanabe Y, Honsho M, Hirose T, Noguchi Y, Nonaka K, Sennari G, Matsui H, Kaito C, Hanaki H, Asami Y, Sunazuka T. Total Syntheses and Chemical Biology Studies of Hymeglusin and Fusarilactone A, Novel Circumventors of β-Lactam Drug Resistance in Methicillin-Resistant Staphylococcus aureus. Chemmedchem. PMID 33783142 DOI: 10.1002/cmdc.202100219 |
0.758 |
|
| 2021 |
Sugawara A, Takada H, Hirose T, Kimishima A, Yamada T, Toda M, Kojima T, Matsumaru T, Sunazuka T. Pd-catalyzed Regio- and Stereoselective Hydrostannylation of an Alkyl Ethynyl Ether/One-Pot Stille Coupling Enables the Synthesis of 14-Membered Macrolactone of Luminamicin. Organic Letters. PMID 33591766 DOI: 10.1021/acs.orglett.1c00183 |
0.752 |
|
| 2020 |
Sadamatsu H, Takahashi K, Tashiro H, Kurihara Y, Kato G, Uchida M, Noguchi Y, Kurata K, Ōmura S, Sunazuka T, Kimura S, Sueoka-Aragane N. The Nonantibiotic Macrolide EM900 Attenuates House Dust Mite-Induced Airway Inflammation in a Mouse Model of Obesity-Associated Asthma. International Archives of Allergy and Immunology. 1-10. PMID 32599580 DOI: 10.1159/000508709 |
0.42 |
|
| 2020 |
Matsuo H, Noguchi Y, Miyano R, Higo M, Nonaka K, Sunazuka T, Takahashi Y, Ōmura S, Nakashima T. Thioporidiols A and B: Two New Sulfur Compounds Discovered by Molybdenum-Catalyzed Oxidation Screening from FKI-7382. Antibiotics (Basel, Switzerland). 9. PMID 32392762 DOI: 10.3390/Antibiotics9050236 |
0.551 |
|
| 2020 |
Sunazuka T, Hirose T, Ikeda A, Tsutsui A, Ōmura S. Rapid Exploration of Novel Anthelmintic Agents from Alkyne-Bearing Avermectin Derivatives via Click Chemistry Heterocycles. 101: 116. DOI: 10.3987/Com-19-S(F)18 |
0.322 |
|
| 2020 |
Watanabe A, Noguchi Y, Hirose T, Monma S, Satake Y, Arai T, Masuda K, Murashima N, Shiomi K, Ōmura S, Sunazuka T. Efficient synthesis of a ryanodine binding inhibitor verticilide using two practical approaches Tetrahedron Letters. 61: 151699. DOI: 10.1016/J.Tetlet.2020.151699 |
0.35 |
|
| 2019 |
Miyano R, Matsuo H, Mokudai T, Noguchi Y, Higo M, Nonaka K, Niwano Y, Sunazuka T, Shiomi K, Takahashi Y, Ōmura S, Nakashima T. Trichothioneic acid, a new antioxidant compound produced by the fungal strain Trichoderma virens FKI-7573. Journal of Bioscience and Bioengineering. PMID 31837993 DOI: 10.1016/J.Jbiosc.2019.11.007 |
0.492 |
|
| 2019 |
Sadamatsu H, Takahashi K, Tashiro H, Kato G, Noguchi Y, Kurata K, Ōmura S, Kimura S, Sunazuka T, Sueoka-Aragane N. The non-antibiotic macrolide EM900 attenuates HDM and poly(I:C)-induced airway inflammation with inhibition of macrophages in a mouse model. Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]. PMID 31820024 DOI: 10.1007/S00011-019-01302-3 |
0.467 |
|
| 2019 |
Goto K, Horikoshi R, Nakamura S, Mitomi M, Oyama K, Hirose T, Sunazuka T, Ōmura S. Synthesis of pyripyropene derivatives and their pest-control efficacy. Journal of Pesticide Science. 44: 255-263. PMID 31777444 DOI: 10.1584/Jpestics.D19-032 |
0.547 |
|
| 2019 |
Matsuo H, Hirose T, Mokudai T, Nonaka K, Niwano Y, Sunazuka T, Takahashi Y, Ōmura S, Nakashima T. Absolute structure and anti-oxidative activity of chaetochiversin C isolated from fungal strain Neocosmospora sp. FKI-7792 by physicochemical screening. The Journal of General and Applied Microbiology. PMID 31735764 DOI: 10.2323/Jgam.2019.06.001 |
0.512 |
|
| 2019 |
Matsuo H, Nakanishi J, Noguchi Y, Kitagawa K, Shigemura K, Sunazuka T, Takahashi Y, Ōmura S, Nakashima T. Nanaomycin K, a new epithelial-mesenchymal transition inhibitor produced by the actinomycete "Streptomyces rosa subsp. notoensis" OS-3966. Journal of Bioscience and Bioengineering. PMID 31582334 DOI: 10.1016/J.Jbiosc.2019.09.007 |
0.465 |
|
| 2019 |
Tran DH, Sugamata R, Hirose T, Suzuki S, Noguchi Y, Sugawara A, Ito F, Yamamoto T, Kawachi S, Akagawa KS, Ōmura S, Sunazuka T, Ito N, Mimaki M, Suzuki K. Azithromycin, a 15-membered macrolide antibiotic, inhibits influenza A(H1N1)pdm09 virus infection by interfering with virus internalization process. The Journal of Antibiotics. PMID 31300721 DOI: 10.1038/S41429-019-0204-X |
0.452 |
|
| 2019 |
Watanabe M, Sugawara A, Noguchi Y, Hirose T, Ōmura S, Sunazuka T, Horie R. Jietacins, azoxy natural products, as novel NF-κB inhibitors: Discovery, synthesis, biological activity, and mode of action. European Journal of Medicinal Chemistry. 178: 636-647. PMID 31226655 DOI: 10.1016/J.Ejmech.2019.05.079 |
0.5 |
|
| 2019 |
Goto K, Horikoshi R, Mitomi M, Oyama K, Hirose T, Sunazuka T, Ōmura S. Synthesis and insecticidal efficacy of pyripyropene derivatives. Part II-Invention of afidopyropen. The Journal of Antibiotics. PMID 31222131 DOI: 10.1038/S41429-019-0193-9 |
0.517 |
|
| 2019 |
Sakai K, Unten Y, Iwatsuki M, Matsuo H, Fukasawa W, Hirose T, Chinen T, Nonaka K, Nakashima T, Sunazuka T, Usui T, Murai M, Miyoshi H, Asami Y, Ōmura S, et al. Fusaramin, an antimitochondrial compound produced by Fusarium sp., discovered using multidrug-sensitive Saccharomyces cerevisiae. The Journal of Antibiotics. PMID 31204387 DOI: 10.1038/S41429-019-0197-5 |
0.534 |
|
| 2019 |
Uchimura T, Nakamura DS, Link EM, Noguchi Y, Ōmura S, Sunazuka T, Greenblatt DJ, Zeng L. Erythromycin acts through the ghrelin receptor to attenuate inflammatory responses in chondrocytes and maintain joint integrity. Biochemical Pharmacology. PMID 30862504 DOI: 10.1016/J.Bcp.2019.03.014 |
0.481 |
|
| 2019 |
Hayashi Y, Fukasawa W, Hirose T, Iwatsuki M, Hokari R, Ishiyama A, Kanaida M, Nonaka K, Také A, Otoguro K, O Mura S, Shiomi K, Sunazuka T. Kozupeptins, Antimalarial Agents Produced by Paracamarosporium Species: Isolation, Structural Elucidation, Total Synthesis, and Bioactivity. Organic Letters. PMID 30859827 DOI: 10.1021/Acs.Orglett.9B00483 |
0.416 |
|
| 2018 |
Matsuo H, Noguchi Y, Také A, Nakanishi J, Shigemura K, Sunazuka T, Takahashi Y, Ōmura S, Nakashima T. Nanaomycin I and J: New nanaomycins generated by mycothiol-mediated compounds from "Streptomyces rosa subsp. notoensis" OS-3966. Journal of Bioscience and Bioengineering. PMID 30503170 DOI: 10.1016/J.Jbiosc.2018.10.013 |
0.494 |
|
| 2018 |
Horikoshi R, Goto K, Mitomi M, Oyama K, Sunazuka T, Ōmura S. Insecticidal properties of pyripyropene A, a microbial secondary metabolite, against agricultural pests. Journal of Pesticide Science. 43: 266-271. PMID 30479548 DOI: 10.1584/Jpestics.D18-030 |
0.507 |
|
| 2018 |
Wakayama N, Matsune S, Takahara E, Sekine K, Yoshioka Y, Ishida M, Yamaguchi S, Okubo K, Sunazuka T, Ōmura S. Anti-Inflammatory Effects of EM900 on Cultured Human Nasal Epithelial Cells. Journal of Nippon Medical School = Nippon Ika Daigaku Zasshi. 85: 265-270. PMID 30464143 DOI: 10.1272/Jnms.Jnms.2018_85-42 |
0.496 |
|
| 2018 |
Sakai K, Hirose T, Iwatsuki M, Chinen T, Kimura T, Suga T, Nonaka K, Nakashima T, Sunazuka T, Usui T, Asami Y, O Mura S, Shiomi K. Pestynol, an Antifungal Compound Discovered Using a Saccharomyces cerevisiae 12geneΔ0HSR-iERG6-Based Assay. Journal of Natural Products. PMID 29975062 DOI: 10.1021/Acs.Jnatprod.8B00200 |
0.329 |
|
| 2018 |
Goto K, Horikoshi R, Mitomi M, Oyama K, Hirose T, Sunazuka T, Ōmura S. Synthesis and insecticidal efficacy of pyripyropene derivatives focusing on the C-1, C-7, and C-11 positions' substituent groups. The Journal of Antibiotics. PMID 29789612 DOI: 10.1038/S41429-018-0064-9 |
0.477 |
|
| 2018 |
Yamada T, Yagita M, Kobayashi Y, Sennari G, Shimamura H, Matsui H, Horimatsu Y, Hanaki H, Hirose T, Omura S, Sunazuka T. Synthesis and Evaluation of Antibacterial Activity of Bottromycins. The Journal of Organic Chemistry. PMID 29560726 DOI: 10.1021/Acs.Joc.8B00045 |
0.619 |
|
| 2017 |
Sugawara A, Kubo M, Hirose T, Yahagi K, Tsunoda N, Noguchi Y, Nakashima T, Takahashi Y, Welz C, Mueller D, Mertens C, Koebberling J, Ōmura S, Sunazuka T. Jietacins, azoxy antibiotics with potent nematocidal activity: Design, synthesis, and biological evaluation against parasitic nematodes. European Journal of Medicinal Chemistry. 145: 524-538. PMID 29335213 DOI: 10.1016/J.Ejmech.2017.12.031 |
0.546 |
|
| 2017 |
Sennari G, Saito R, Hirose T, Iwatsuki M, Ishiyama A, Hokari R, Otoguro K, Ōmura S, Sunazuka T. Antimalarial troponoids, puberulic acid and viticolins; divergent synthesis and structure-activity relationship studies. Scientific Reports. 7: 7259. PMID 28775291 DOI: 10.1038/S41598-017-07718-3 |
0.588 |
|
| 2017 |
Ando H, Kimishima A, Ohara M, Hirose T, Matsumaru T, Takada H, Morodome K, Miyamoto T, Sugawara A, Ōmura S, Sunazuka T. Toward the total synthesis of luminamicin; an anaerobic antibiotic: construction of highly functionalized cis-decalin containing a bridged ether moiety. The Journal of Antibiotics. PMID 28676718 DOI: 10.1038/Ja.2017.77 |
0.773 |
|
| 2017 |
Sugawara A, Maruyama H, Shibusawa S, Matsui H, Hirose T, Tsutsui A, Froyman R, Ludwig C, Koebberling J, Hanaki H, Kleefeld G, Ōmura S, Sunazuka T. 5-O-Mycaminosyltylonolide antibacterial derivatives: design, synthesis and bioactivity. The Journal of Antibiotics. PMID 28559578 DOI: 10.1038/Ja.2017.61 |
0.505 |
|
| 2017 |
Fukumoto A, Kim YP, Iwatsuki M, Hirose T, Sunazuka T, Hanaki H, Ōmura S, Shiomi K. Naphthacemycins, novel circumventors of β-lactam resistance in MRSA, produced by Streptomyces sp. KB-3346-5. II. Structure elucidation. The Journal of Antibiotics. PMID 28293036 DOI: 10.1038/Ja.2017.29 |
0.529 |
|
| 2017 |
Katz N, Araújo N, Coelho PM, Morel CM, Linde-Arias AR, Yamada T, Horimatsu Y, Suzuki K, Sunazuka T, Ōmura S. Ivermectin efficacy against Biomphalaria, intermediate host snail vectors of Schistosomiasis. The Journal of Antibiotics. PMID 28293033 DOI: 10.1038/Ja.2017.31 |
0.453 |
|
| 2017 |
Horikoshi R, Goto K, Mitomi M, Oyama K, Sunazuka T, Omacr Mura S. Identification of pyripyropene A as a promising insecticidal compound in a microbial metabolite screening. The Journal of Antibiotics. PMID 28074053 DOI: 10.1038/Ja.2016.155 |
0.33 |
|
| 2017 |
Yamada T, Horimatsu Y, Hirose T, Sugawara A, Ōmura S, Sunazuka T. Stereo- and substituent-enabled divergent synthesis of 5,6-spiroketal analogs of avermectin containing a triazole function Tetrahedron Letters. 58: 3119-3124. DOI: 10.1016/J.Tetlet.2017.06.072 |
0.394 |
|
| 2016 |
Takada H, Yamada T, Hirose T, Ishihara T, Nakashima T, Takahashi YK, O Mura S, Sunazuka T. Total Synthesis and Determination of the Absolute Configuration of Naturally Occurring Mangromicin A, with Potent Antitrypanosomal Activity. Organic Letters. PMID 27936806 DOI: 10.1021/Acs.Orglett.6B03512 |
0.399 |
|
| 2016 |
Hirose T, Kojima Y, Matsui H, Hanaki H, Iwatsuki M, Shiomi K, Ōmura S, Sunazuka T. Total synthesis of (±)-naphthacemycin A9, possessing both antibacterial activity against methicillin-resistant Staphylococcus aureus and circumventing effect of β-lactam resistance. The Journal of Antibiotics. PMID 27924114 DOI: 10.1038/Ja.2016.141 |
0.55 |
|
| 2016 |
Fuse S, Matsumura K, Johmoto K, Uekusa H, Tanaka H, Hirose T, Sunazuka T, Ōmura S, Takahashi T. The Design, Synthesis, and Evaluation of 1,5,7-Trisubstituted-3-Pyridyl-Xanthones for Use as Insecticides Starting from Pyripyropene A. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 27862416 DOI: 10.1002/Chem.201603980 |
0.546 |
|
| 2016 |
Yamamoto T, Matsui H, Yamaji K, Takahashi T, Øverby A, Nakamura M, Matsumoto A, Nonaka K, Sunazuka T, Ōmura S, Nakano H. Narrow-spectrum inhibitors targeting an alternative menaquinone biosynthetic pathway of Helicobacter pylori. Journal of Infection and Chemotherapy : Official Journal of the Japan Society of Chemotherapy. PMID 27346378 DOI: 10.1016/J.Jiac.2016.05.012 |
0.509 |
|
| 2016 |
Noguchi Y, Hirose T, Ishiyama A, Iwatsuki M, Otoguro K, Sunazuka T, Ōmura S. Synthesis and stereochemical determination of an antiparasitic pseudo-aminal type monoterpene indole alkaloid. Journal of Natural Medicines. PMID 27324906 DOI: 10.1007/S11418-016-1012-2 |
0.587 |
|
| 2016 |
Yamada T, Suzuki K, Hirose T, Furuta T, Ueda Y, Kawabata T, Ōmura S, Sunazuka T. Organocatalytic Site-Selective Acylation of Avermectin B2a, a Unique Endectocidal Drug. Chemical & Pharmaceutical Bulletin. PMID 27075247 DOI: 10.1248/Cpb.C16-00205 |
0.463 |
|
| 2016 |
Mukai S, Moriya S, Hiramoto M, Kazama H, Kokuba H, Che XF, Yokoyama T, Sakamoto S, Sugawara A, Sunazuka T, Ōmura S, Handa H, Itoi T, Miyazawa K. Macrolides sensitize EGFR-TKI-induced non-apoptotic cell death via blocking autophagy flux in pancreatic cancer cell lines. International Journal of Oncology. 48: 45-54. PMID 26718641 DOI: 10.3892/Ijo.2015.3237 |
0.462 |
|
| 2016 |
Hirose T, Sunazuka T, Ōmura S. Rapid Identification via In Situ Click Chemistry of a Novel Chitinase Inhibitor Journal of Synthetic Organic Chemistry, Japan. 74: 1090-1097. DOI: 10.5059/Yukigoseikyokaishi.74.1090 |
0.302 |
|
| 2016 |
Oshita J, Noguchi Y, Watanabe A, Sennari G, Sato S, Hirose T, Oikawa D, Inahashi Y, Iwatsuki M, Ishiyama A, Omura S, Sunazuka T. Towards the total synthesis of the anti-trypanosomal macrolide, Actinoallolides: Construction of a key linear intermediate Tetrahedron Letters. 57: 357-360. DOI: 10.1016/J.Tetlet.2015.12.022 |
0.35 |
|
| 2015 |
Toguchi S, Hirose T, Yorita K, Fukui K, Sharpless KB, Ōmura S, Sunazuka T. In situ Click Chemistry for the Identification of a Potent D-Amino Acid Oxidase Inhibitor. Chemical & Pharmaceutical Bulletin. PMID 26686243 DOI: 10.1248/Cpb.C15-00867 |
0.533 |
|
| 2015 |
Lusamba Kalonji N, Nomura K, Kawase T, Ota C, Kubo H, Sato T, Yanagisawa T, Sunazuka T, Ōmura S, Yamaya M. The non-antibiotic macrolide EM900 inhibits rhinovirus infection and cytokine production in human airway epithelial cells. Physiological Reports. 3. PMID 26462747 DOI: 10.14814/Phy2.12557 |
0.469 |
|
| 2015 |
Sugawara A, Shima H, Sueki A, Hirose T, Matsui H, Nakano H, Hanaki H, Akagawa KS, Ōmura S, Sunazuka T. Non-antibiotic 12-membered macrolides: design, synthesis and biological evaluation in a cigarette-smoking model. The Journal of Antibiotics. PMID 26419414 DOI: 10.1038/Ja.2015.91 |
0.526 |
|
| 2015 |
Yamada T, Ideguchi-Matsushita T, Hirose T, Shirahata T, Hokari R, Ishiyama A, Iwatsuki M, Sugawara A, Kobayashi Y, Otoguro K, ?mura S, Sunazuka T. Asymmetric Total Synthesis of Indole Alkaloids Containing an Indoline Spiroaminal Framework. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 26147398 DOI: 10.1002/Chem.201501150 |
0.362 |
|
| 2015 |
Sugawara A, Maita N, Gouda H, Yamamoto T, Hirose T, Kimura S, Saito Y, Nakano H, Kasai T, Nakano H, Shiomi K, Hirono S, Watanabe T, Taniguchi H, O?mura S, ... Sunazuka T, et al. Creation of Customized Bioactivity within a 14-Membered Macrolide Scaffold: Design, Synthesis, and Biological Evaluation Using a Family-18 Chitinase. Journal of Medicinal Chemistry. 58: 4984-4997. PMID 26030312 DOI: 10.1021/Acs.Jmedchem.5B00175 |
0.522 |
|
| 2015 |
Ishii T, Nonaka K, Sugawara A, Iwatsuki M, Masuma R, Hirose T, Sunazuka T, ?mura S, Shiomi K. Cinatrins D and E, and virgaricin B, three novel compounds produced by a fungus, Virgaria boninensis FKI-4958. The Journal of Antibiotics. PMID 25899122 DOI: 10.1038/Ja.2015.45 |
0.353 |
|
| 2015 |
Tojima I, Shimizu S, Ogawa T, Kouzaki H, Omura S, Sunazuka T, Shimizu T. Anti-inflammatory effects of a novel non-antibiotic macrolide, EM900, on mucus secretion of airway epithelium. Auris, Nasus, Larynx. 42: 332-6. PMID 25769240 DOI: 10.1016/J.Anl.2015.02.003 |
0.499 |
|
| 2015 |
Iwanaga N, Nakamura S, Oshima K, Kajihara T, Takazono T, Miyazaki T, Izumikawa K, Yanagihara K, Sugawara A, Sunazuka T, Omura S, Kohno S. Macrolides Promote CCL2-Mediated Macrophage Recruitment and Clearance of Nasopharyngeal Pneumococcal Colonization in Mice. The Journal of Infectious Diseases. PMID 25767216 DOI: 10.1093/Infdis/Jiv157 |
0.456 |
|
| 2015 |
Inahashi Y, Iwatsuki M, Ishiyama A, Matsumoto A, Hirose T, Oshita J, Sunazuka T, Panbangred W, Takahashi Y, Kaiser M, Otoguro K, ?mura S. Actinoallolides A-E, new anti-trypanosomal macrolides, produced by an endophytic actinomycete, Actinoallomurus fulvus MK10-036. Organic Letters. 17: 864-7. PMID 25635351 DOI: 10.1021/Ol5037216 |
0.347 |
|
| 2015 |
Sugawara A, Kubo M, Nakashima T, Hirose T, Tsunoda N, Yahagi K, Asami Y, Yamada T, Shiomi K, Takahashi Y, Omura S, Sunazuka T. Jietacins with potent nematocidal activity; Efficient isolation of novel analogs and divergent total synthesis of jietacin A, B, C, and D the paper is dedicated to Professor Iwao Ojima on the occasion of his 70th birthday Tetrahedron. 71: 2149-2157. DOI: 10.1016/J.Tet.2015.02.038 |
0.404 |
|
| 2014 |
Sennari G, Hirose T, Iwatsuki M, ?mura S, Sunazuka T. A concise total synthesis of puberulic acid, a potent antimalarial agent. Chemical Communications (Cambridge, England). 50: 8715-8. PMID 24964220 DOI: 10.1039/C4Cc03134B |
0.336 |
|
| 2014 |
Sugamata R, Sugawara A, Nagao T, Suzuki K, Hirose T, Yamamoto K, Oshima M, Kobayashi K, Sunazuka T, Akagawa KS, ?mura S, Nakayama T, Suzuki K. Leucomycin A3, a 16-membered macrolide antibiotic, inhibits influenza A virus infection and disease progression. The Journal of Antibiotics. 67: 213-22. PMID 24496145 DOI: 10.1038/Ja.2013.132 |
0.309 |
|
| 2014 |
Nakano H, Sugawara A, Hirose T, Gouda H, Hirono S, Omura S, Sunazuka T. An architectonic macrolide library based on a C2-symmetric macrodiolide toward pharmaceutical compositions Tetrahedron. 71: 6569-6579. DOI: 10.1016/J.Tet.2015.01.030 |
0.354 |
|
| 2013 |
Hirose T, Maita N, Gouda H, Koseki J, Yamamoto T, Sugawara A, Nakano H, Hirono S, Shiomi K, Watanabe T, Taniguchi H, Sharpless KB, Omura S, Sunazuka T. Observation of the controlled assembly of preclick components in the in situ click chemistry generation of a chitinase inhibitor. Proceedings of the National Academy of Sciences of the United States of America. 110: 15892-7. PMID 24043811 DOI: 10.1073/Pnas.1315049110 |
0.5 |
|
| 2013 |
Ideguchi T, Yamada T, Shirahata T, Hirose T, Sugawara A, Kobayashi Y, ?mura S, Sunazuka T. Asymmetric total synthesis of neoxaline. Journal of the American Chemical Society. 135: 12568-71. PMID 23957424 DOI: 10.1021/Ja406657V |
0.346 |
|
| 2013 |
Hirose T, Noguchi Y, Furuya Y, Ishiyama A, Iwatsuki M, Otoguro K, Omura S, Sunazuka T. Structure determination and total synthesis of (+)-16-hydroxy-16,22-dihydroapparicine. Chemistry (Weinheim An Der Bergstrasse, Germany). 19: 10741-50. PMID 23788004 DOI: 10.1002/Chem.201300292 |
0.555 |
|
| 2013 |
Wakasugi M, Gouda H, Hirose T, Sugawara A, Yamamoto T, Shiomi K, Sunazuka T, ?mura S, Hirono S. Human acidic mammalian chitinase as a novel target for anti-asthma drug design using in silico screening. Bioorganic & Medicinal Chemistry. 21: 3214-20. PMID 23623259 DOI: 10.1016/J.Bmc.2013.03.047 |
0.357 |
|
| 2013 |
Sugawara A, Tanaka T, Hirose T, Ishiyama A, Iwatsuki M, Takahashi Y, Otoguro K, ?mura S, Sunazuka T. Borrelidin analogues with antimalarial activity: design, synthesis and biological evaluation against Plasmodium falciparum parasites. Bioorganic & Medicinal Chemistry Letters. 23: 2302-5. PMID 23499502 DOI: 10.1016/J.Bmcl.2013.02.075 |
0.352 |
|
| 2013 |
Li YJ, Shimizu T, Hirata Y, Inagaki H, Takizawa H, Azuma A, Kawada T, Sugawara I, Kudoh S, Sunazuka T, Omura S. EM, EM703 inhibit NF-kB activation induced by oxidative stress from diesel exhaust particle in human bronchial epithelial cells: importance in IL-8 transcription. Pulmonary Pharmacology & Therapeutics. 26: 318-24. PMID 23291319 DOI: 10.1016/J.Pupt.2012.12.010 |
0.474 |
|
| 2013 |
Tsutsui A, Hirose T, Ishiyama A, Iwatsuki M, Yokota A, Maruyama H, Matsui H, Otoguro K, Hanaki H, Omura S, Sunazuka T. Antimalarial C-9 oxime derivatives from desmycosin, produced by click chemistry. The Journal of Antibiotics. 66: 191-4. PMID 23232930 DOI: 10.1038/Ja.2012.113 |
0.49 |
|
| 2013 |
Sugawara A, Kimishima A, Takada H, Hirose T, Matsumaru T, Ōmura S, Sunazuka T. Toward the Total Synthesis of Luminamicin, a Specific Anti-Anaerobic Bacteriacide Planta Medica. 79. DOI: 10.1055/S-0033-1348544 |
0.35 |
|
| 2012 |
Sugawara A, Sueki A, Hirose T, Shima H, Akagawa KS, Omura S, Sunazuka T. Novel 12-membered non-antibiotic macrolides, EM900 series with anti-inflammatory and/or immunomodulatory activity; synthesis, structure-activity relationships and in vivo study. The Journal of Antibiotics. 65: 487-90. PMID 22760298 DOI: 10.1038/Ja.2012.51 |
0.556 |
|
| 2012 |
Suzuki T, Choi JH, Kawaguchi T, Yamashita K, Morita A, Hirai H, Nagai K, Hirose T, Omura S, Sunazuka T, Kawagishi H. Makomotindoline from Makomotake, Zizania latifolia infected with Ustilago esculenta. Bioorganic & Medicinal Chemistry Letters. 22: 4246-8. PMID 22672800 DOI: 10.1016/J.Bmcl.2012.05.021 |
0.484 |
|
| 2012 |
Gouda H, Kobayashi Y, Yamada T, Ideguchi T, Sugawara A, Hirose T, Omura S, Sunazuka T, Hirono S. Three-dimensional solution structure of bottromycin A2: a potent antibiotic active against methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococci. Chemical & Pharmaceutical Bulletin. 60: 169-71. PMID 22293474 DOI: 10.1248/Cpb.60.169 |
0.639 |
|
| 2012 |
Kimishima A, Hirose T, Sugawara A, Matsumaru T, Nakamura K, Katsuyama K, Toda M, Takada H, Masuma R, Omura S, Sunazuka T. Toward the total synthesis of Luminamicin: Construction of 14-membered lactone framework possessing versatile enol ether moiety Tetrahedron Letters. 53: 2813-2816. DOI: 10.1016/J.Tetlet.2012.03.098 |
0.394 |
|
| 2012 |
Noguchi Y, Hirose T, Furuya Y, Ishiyama A, Otoguro K, Omura S, Sunazuka T. The first total synthesis and reassignment of the relative stereochemistry of 16-hydroxy-16,22-dihydroapparicine Tetrahedron Letters. 53: 1802-1807. DOI: 10.1016/J.Tetlet.2012.01.110 |
0.384 |
|
| 2011 |
Otsu K, Ishinaga H, Suzuki S, Sugawara A, Sunazuka T, Omura S, Jono H, Takeuchi K. Effects of a novel nonantibiotic macrolide, EM900, on cytokine and mucin gene expression in a human airway epithelial cell line. Pharmacology. 88: 327-32. PMID 22116077 DOI: 10.1159/000334339 |
0.481 |
|
| 2011 |
Sugawara A, Sueki A, Hirose T, Nagai K, Gouda H, Hirono S, Shima H, Akagawa KS, Omura S, Sunazuka T. Novel 12-membered non-antibiotic macrolides from erythromycin A; EM900 series as novel leads for anti-inflammatory and/or immunomodulatory agents. Bioorganic & Medicinal Chemistry Letters. 21: 3373-6. PMID 21524580 DOI: 10.1016/J.Bmcl.2011.04.004 |
0.533 |
|
| 2011 |
Inahashi Y, Iwatsuki M, Ishiyama A, Namatame M, Nishihara-Tsukashima A, Matsumoto A, Hirose T, Sunazuka T, Yamada H, Otoguro K, Takahashi Y, Omura S, Shiomi K. Spoxazomicins A-C, novel antitrypanosomal alkaloids produced by an endophytic actinomycete, Streptosporangium oxazolinicum K07-0460(T). The Journal of Antibiotics. 64: 303-7. PMID 21386848 DOI: 10.1038/Ja.2011.16 |
0.49 |
|
| 2011 |
Hirose T, Iwatsuki M, Satoshimura O, Sunazuka T. Isolation, total synthesis and determination of the absolute configuration of guadinomines; potent inhibitors of a bacterial type III secretion system Yuki Gosei Kagaku Kyokaishi/Journal of Synthetic Organic Chemistry. 69: 775-788. DOI: 10.5059/Yukigoseikyokaishi.69.775 |
0.416 |
|
| 2011 |
Hirose T, Kasai T, Akimoto T, Endo A, Sugawara A, Nagasawa K, Shiomi K, Omura S, Sunazuka T. Solution-phase total synthesis of the hydrophilic natural product argifin using 3,4,5-tris(octadecyloxy)benzyl tag Tetrahedron. 67: 6633-6643. DOI: 10.1016/J.Tet.2011.05.073 |
0.331 |
|
| 2010 |
Kobayashi Y, Ichioka M, Hirose T, Nagai K, Matsumoto A, Matsui H, Hanaki H, Masuma R, Takahashi Y, Omura S, Sunazuka T. Bottromycin derivatives: efficient chemical modifications of the ester moiety and evaluation of anti-MRSA and anti-VRE activities. Bioorganic & Medicinal Chemistry Letters. 20: 6116-20. PMID 20833545 DOI: 10.1016/J.Bmcl.2010.08.037 |
0.675 |
|
| 2010 |
Gouda H, Sunazuka T, Hirose T, Iguchi K, Yamaotsu N, Sugawara A, Noguchi Y, Saito Y, Yamamoto T, Watanabe T, Shiomi K, Omura S, Hirono S. NMR spectroscopy and computational analysis of interaction between Serratia marcescens chitinase B and a dipeptide derived from natural-product cyclopentapeptide chitinase inhibitor argifin. Bioorganic & Medicinal Chemistry. 18: 5835-44. PMID 20667742 DOI: 10.1016/J.Bmc.2010.06.093 |
0.471 |
|
| 2010 |
Nagai T, Shimizu Y, Shirahata T, Sunazuka T, Kiyohara H, Omura S, Yamada H. Oral adjuvant activity for nasal influenza vaccines caused by combination of two trihydroxy fatty acid stereoisomers from the tuber of Pinellia ternata. International Immunopharmacology. 10: 655-61. PMID 20230917 DOI: 10.1016/J.Intimp.2010.03.004 |
0.468 |
|
| 2010 |
Shirahata T, Matsuo J, Teruya S, Hirata N, Kurimoto T, Akimoto N, Sunazuka T, Kaji E, Omura S. Improved catalytic and stereoselective glycosylation with glycosyl N-trichloroacetylcarbamate: application to various 1-hydroxy sugars. Carbohydrate Research. 345: 740-9. PMID 20207348 DOI: 10.1016/J.Carres.2010.01.011 |
0.508 |
|
| 2010 |
Hirose T, Sunazuka T, Omura S. Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms. Proceedings of the Japan Academy. Series B, Physical and Biological Sciences. 86: 85-102. PMID 20154467 DOI: JST.JSTAGE/pjab/86.85 |
0.501 |
|
| 2010 |
Namikawa H, Sunazuka T, Kitamura Y, Suzuki T, Hamasaki Y, Yamazaki S, Omura S, Hatamochi A. Effect of erythromycin A and its new derivative EM201 on type I collagen production by cultured dermal fibroblasts. Archives of Dermatological Research. 302: 341-8. PMID 19578864 DOI: 10.1007/S00403-009-0977-Z |
0.475 |
|
| 2010 |
Tsutsui A, Furuya Y, Hirose T, Kim R, Masuma R, Matsumoto A, Takahashi Y, Ishiyama A, Namatame M, Otoguro K, Omura S, Sunazuka T. Boromycin derivatives: Synthesis and antimalarial activity in vitro and in vivo Heterocycles. 82: 289-295. DOI: 10.3987/Com-10-S(E)55 |
0.383 |
|
| 2009 |
Inoue K, Watanabe S, Ideue R, Sunazuka T, Omura S, Kumazawa Y. [Suppression of endotoxic shock by macrolide derivative, EM900, and the mechanism involved in the process]. The Japanese Journal of Antibiotics. 62: 23-6. PMID 22452050 |
0.371 |
|
| 2009 |
Yamauchi Y, Kouyama T, Itakura S, Kamiya S, Nagase T, Sunazuka T, Omura S, Takizawa H. [The effects of macrolides (EM900, clarithromycin and azithromycin) on IL-17-induced IL-8 production by airway epithelial cells]. The Japanese Journal of Antibiotics. 62: 17-21. PMID 22452048 |
0.36 |
|
| 2009 |
Shimizu S, Shimizu T, Sunazuka T, Omura S. [Action of EM900 on mucus secretion by the respiratory epithelial cells]. The Japanese Journal of Antibiotics. 62: 13-6. PMID 22452047 |
0.349 |
|
| 2009 |
Ri E, Shimizuq T, Hirata Y, Inagaki H, Takizawa H, Azuma A, Kawada T, Sugawara I, Kudo S, Sunazuka T, Omura S. [EM and EM703 suppress inflammatory cytokines formation by human respiratory epithelial cells provoked by diesel exhaust particles]. The Japanese Journal of Antibiotics. 62: 9-12. PMID 22452046 |
0.365 |
|
| 2009 |
Kojima Y, Sunazuka T, Nagai K, Hirose T, Namatame M, Ishiyama A, Otoguro K, Omura S. Solid-phase synthesis and biological activity of malformin C and its derivatives. The Journal of Antibiotics. 62: 681-6. PMID 19876076 DOI: 10.1038/Ja.2009.100 |
0.542 |
|
| 2009 |
Gouda H, Terashima S, Iguchi K, Sugawara A, Saito Y, Yamamoto T, Hirose T, Shiomi K, Sunazuka T, Omura S, Hirono S. Molecular modeling of human acidic mammalian chitinase in complex with the natural-product cyclopentapeptide chitinase inhibitor argifin. Bioorganic & Medicinal Chemistry. 17: 6270-8. PMID 19666229 DOI: 10.1016/J.Bmc.2009.07.045 |
0.485 |
|
| 2009 |
Hirose T, Sunazuka T, Sugawara A, Noguchi Y, Tanaka T, Iguchi K, Yamamoto T, Gouda H, Shiomi K, Omura S. Solid-phase total synthesis of the chitinase inhibitor Argadin using a supported acetal resin. The Journal of Antibiotics. 62: 495-500. PMID 19575041 DOI: 10.1038/Ja.2009.57 |
0.537 |
|
| 2009 |
Gouda H, Sunazuka T, Iguchi K, Sugawara A, Hirose T, Noguchi Y, Saito Y, Yanai Y, Yamamoto T, Watanabe T, Shiomi K, Omura S, Hirono S. Computer-aided rational molecular design of argifin-derivatives with increased inhibitory activity against chitinase B from Serratia marcescens. Bioorganic & Medicinal Chemistry Letters. 19: 2630-3. PMID 19395258 DOI: 10.1016/J.Bmcl.2009.04.013 |
0.53 |
|
| 2009 |
Ohshiro T, Matsuda D, Nagai K, Doi T, Sunazuka T, Takahashi T, Rudel LL, Omura S, Tomoda H. The selectivity of beauveriolide derivatives in inhibition toward the two isozymes of acyl-CoA: cholesterol acyltransferase. Chemical & Pharmaceutical Bulletin. 57: 377-81. PMID 19336931 DOI: 10.1248/Cpb.57.377 |
0.513 |
|
| 2009 |
Hirose T, Sunazuka T, Sugawara A, Endo A, Iguchi K, Yamamoto T, Ui H, Shiomi K, Watanabe T, Sharpless KB, Omura S. Chitinase inhibitors: extraction of the active framework from natural argifin and use of in situ click chemistry. The Journal of Antibiotics. 62: 277-82. PMID 19329983 DOI: 10.1038/ja.2009.28 |
0.502 |
|
| 2009 |
Sunazuka T, Sugawara A, Iguchi K, Hirose T, Nagai K, Noguchi Y, Saito Y, Yamamoto T, Ui H, Gouda H, Shiomi K, Watanabe T, Omura S. Argifin; efficient solid phase total synthesis and evaluation of analogues of acyclic peptide. Bioorganic & Medicinal Chemistry. 17: 2751-8. PMID 19297173 DOI: 10.1016/J.Bmc.2009.02.047 |
0.534 |
|
| 2009 |
Teramoto T, Matsunaga T, Toba M, Sunazuka T, Omura S, Ohmori S. Role of dexamethasone and oncostatin M on the formation of vacuoles in human fetal liver cells. Biological & Pharmaceutical Bulletin. 32: 209-12. PMID 19182377 DOI: 10.1248/Bpb.32.209 |
0.439 |
|
| 2009 |
Shimamura H, Gouda H, Nagai K, Hirose T, Ichioka M, Furuya Y, Kobayashi Y, Hirono S, Sunazuka T, Omura S. Structure determination and total synthesis of bottromycin A2: a potent antibiotic against MRSA and VRE. Angewandte Chemie (International Ed. in English). 48: 914-7. PMID 19115340 DOI: 10.1002/Anie.200804138 |
0.64 |
|
| 2008 |
Ohshiro T, Ohte S, Matsuda D, Ohtawa M, Nagamitsu T, Sunazuka T, Harigaya Y, Rudel LL, Omura S, Tomoda H. Selectivity of pyripyropene derivatives in inhibition toward acyl-CoA:cholesterol acyltransferase 2 isozyme. The Journal of Antibiotics. 61: 503-8. PMID 18997389 DOI: 10.1038/Ja.2008.67 |
0.497 |
|
| 2008 |
Komuro I, Sunazuka T, Akagawa KS, Yokota Y, Iwamoto A, Omura S. Erythromycin derivatives inhibit HIV-1 replication in macrophages through modulation of MAPK activity to induce small isoforms of C/EBPbeta. Proceedings of the National Academy of Sciences of the United States of America. 105: 12509-14. PMID 18719105 DOI: 10.1073/Pnas.0805504105 |
0.462 |
|
| 2008 |
Hirose T, Sunazuka T, Tsuchiya S, Tanaka T, Kojima Y, Mori R, Iwatsuki M, Omura S. Total synthesis and determination of the absolute configuration of guadinomines B and C2. Chemistry (Weinheim An Der Bergstrasse, Germany). 14: 8220-38. PMID 18655091 DOI: 10.1002/Chem.200801024 |
0.583 |
|
| 2008 |
Kojima Y, Sunazuka T, Nagai K, Julfakyan K, Fukuda T, Tomoda H, Omura S. Total synthesis of malformin C, an inhibitor of bleomycin-induced G2 arrest. The Journal of Antibiotics. 61: 297-302. PMID 18653995 DOI: 10.1038/ja.2008.42 |
0.453 |
|
| 2008 |
Nagai K, Doi T, Ohshiro T, Sunazuka T, Tomoda H, Takahashi T, Omura S. Synthesis and biological evaluation of a focused library of beauveriolides. Bioorganic & Medicinal Chemistry Letters. 18: 4397-400. PMID 18620856 DOI: 10.1016/J.Bmcl.2008.06.054 |
0.507 |
|
| 2008 |
Yu C, Azuma A, Li Y, Wang C, Abe S, Usuki J, Matsuda K, Kudoh S, Sunazuka T, Omura S. EM703, a new derivative of erythromycin, inhibits transforming growth factor-beta signaling in human lung fibroblasts. Experimental Lung Research. 34: 343-54. PMID 18600500 DOI: 10.1080/01902140802093238 |
0.449 |
|
| 2008 |
Iwatsuki M, Uchida R, Yoshijima H, Ui H, Shiomi K, Kim YP, Hirose T, Sunazuka T, Abe A, Tomoda H, Omura S. Guadinomines, Type III secretion system inhibitors, produced by Streptomyces sp. K01-0509. II: physico-chemical properties and structure elucidation. The Journal of Antibiotics. 61: 230-6. PMID 18503202 DOI: 10.1038/Ja.2008.33 |
0.514 |
|
| 2008 |
Sunazuka T, Shudo H, Nagai K, Yoshida K, Yamaguchi Y, Hanaki H, Omura S. 4'''-N-demethylspiramycin derivatives: synthesis and evaluation of effectiveness against drug-resistant bacteria. The Journal of Antibiotics. 61: 175-84. PMID 18503196 DOI: 10.1038/ja.2008.127 |
0.466 |
|
| 2008 |
Gouda H, Yanai Y, Sugawara A, Sunazuka T, Omura S, Hirono S. Computational analysis of the binding affinities of the natural-product cyclopentapeptides argifin and argadin to chitinase B from Serratia marcescens. Bioorganic & Medicinal Chemistry. 16: 3565-79. PMID 18313305 DOI: 10.1016/J.Bmc.2008.02.017 |
0.454 |
|
| 2008 |
Sunazuka T, Hirose T, Omura S. Efficient total synthesis of novel bioactive microbial metabolites. Accounts of Chemical Research. 41: 302-14. PMID 18217720 DOI: 10.1021/Ar6000044 |
0.59 |
|
| 2008 |
Ikeda H, Sunazuka T, Suzuki H, Hamasaki Y, Yamazaki S, Omura S, Hatamochi A. EM703, the new derivative of erythromycin, inhibits transcription of type I collagen in normal and scleroderma fibroblasts. Journal of Dermatological Science. 49: 195-205. PMID 18036782 DOI: 10.1016/J.Jdermsci.2007.10.006 |
0.473 |
|
| 2008 |
Matsumaru T, Sunazuka T, Hirose T, Ishiyama A, Namatame M, Fukuda T, Tomoda H, Otoguro K, Omura S. Synthesis and biological properties of tensyuic acids B, C, and E, and investigation of the optical purity of natural tensyuic acid B Tetrahedron. 64: 7369-7377. DOI: 10.1016/J.Tet.2008.05.035 |
0.341 |
|
| 2008 |
Sunazuka T, Sugawara A, Nagai K, Hirose T, Yamaguchi Y, Hanaki H, Sharpless K, Omura S. ‘Click Chemistry’ Synthesis of Macrolide Derivatives with Anti-MRSA and Anti-VRE Activity International Journal of Infectious Diseases. 12: e256-e257. DOI: 10.1016/J.Ijid.2008.05.694 |
0.371 |
|
| 2007 |
Sugawara A, Sunazuka T, Hirose T, Nagai K, Yamaguchi Y, Hanaki H, Sharpless KB, Omura S. Design and synthesis via click chemistry of 8,9-anhydroerythromycin A 6,9-hemiketal analogues with anti-MRSA and -VRE activity. Bioorganic & Medicinal Chemistry Letters. 17: 6340-4. PMID 17869508 DOI: 10.1016/J.Bmcl.2007.08.068 |
0.541 |
|
| 2007 |
Shimamura H, Sunazuka T, Izuhara T, Hirose T, Shiomi K, Omura S. Total synthesis and biological evaluation of verticipyrone and analogues. Organic Letters. 9: 65-7. PMID 17192086 DOI: 10.1021/Ol0626140 |
0.569 |
|
| 2007 |
Tsuchiya S, Sunazuka T, Shirahata T, Hirose T, Kaji E, Omura S. A new method for efficient coupling of indole and epoxide catalyzed with YB(OTF)3, and application to the total synthesis of kurasoin B Heterocycles. 72: 91-94. DOI: 10.3987/Com-06-S(K)7 |
0.367 |
|
| 2007 |
Sunazuka T, Handa M, Hirose T, Matsumaru T, Togashi Y, Nakamura K, Iwai Y, Omura S. Synthesis of the oxa-bridged octalin system of two anti-anaerobe antibiotics, luminamicin and lustromycin Tetrahedron Letters. 48: 5297-5300. DOI: 10.1016/J.Tetlet.2007.05.104 |
0.376 |
|
| 2007 |
Hirose T, Sunazuka T, Yamamoto D, Mouri M, Hagiwara Y, Matsumaru T, Kaji E, Omura S. Studies toward the total synthesis of irumamycin: stereoselective preparation of the C(15)-C(27) segment via two-directional chain synthesis Tetrahedron Letters. 48: 413-416. DOI: 10.1016/J.Tetlet.2006.11.079 |
0.326 |
|
| 2006 |
Ui H, Shiomi K, Suzuki H, Hatano H, Morimoto H, Yamaguchi Y, Masuma R, Sunazuka T, Shimamura H, Sakamoto K, Kita K, Miyoshi H, Tomoda H, Omura S. Verticipyrone, a new NADH-fumarate reductase inhibitor, produced by Verticillium sp. FKI-1083. The Journal of Antibiotics. 59: 785-90. PMID 17323645 DOI: 10.1038/Ja.2006.103 |
0.506 |
|
| 2006 |
Monma S, Sunazuka T, Nagai K, Arai T, Shiomi K, Matsui R, Omura S. Verticilide: elucidation of absolute configuration and total synthesis. Organic Letters. 8: 5601-4. PMID 17107082 DOI: 10.1021/Ol0623365 |
0.552 |
|
| 2006 |
Tsuchiya S, Sunazuka T, Hirose T, Mori R, Tanaka T, Iwatsuki M, Omura S. Asymmetric total synthesis of (+)-K01-0509 B: determination of absolute configuration. Organic Letters. 8: 5577-80. PMID 17107076 DOI: 10.1021/Ol062282Z |
0.515 |
|
| 2006 |
Yamamoto D, Sunazuka T, Hirose T, Kojima N, Kaji E, Omura S. Design, synthesis, and biological activities of madindoline analogues. Bioorganic & Medicinal Chemistry Letters. 16: 2807-11. PMID 16481161 DOI: 10.1016/J.Bmcl.2006.01.107 |
0.558 |
|
| 2006 |
Gouda H, Sunazuka T, Yoshida K, Sugawara A, Sakoh Y, Omura S, Hirono S. Three-dimensional solution structure of EM703 with potent promoting activity of monocyte-to-macrophage differentiation. Bioorganic & Medicinal Chemistry Letters. 16: 2496-9. PMID 16480872 DOI: 10.1016/J.Bmcl.2006.01.079 |
0.497 |
|
| 2006 |
Li YJ, Azuma A, Usuki J, Abe S, Matsuda K, Sunazuka T, Shimizu T, Hirata Y, Inagaki H, Kawada T, Takahashi S, Kudoh S, Omura S. EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-beta signaling in lung fibroblasts. Respiratory Research. 7: 16. PMID 16438734 DOI: 10.1186/1465-9921-7-16 |
0.453 |
|
| 2006 |
Nagai K, Doi T, Sekiguchi T, Namatame I, Sunazuka T, Tomoda H, Omura S, Takahashi T. Synthesis and biological evaluation of a beauveriolide analogue library. Journal of Combinatorial Chemistry. 8: 103-9. PMID 16398560 DOI: 10.1021/Cc050084D |
0.543 |
|
| 2006 |
Hirose T, Sunazuka T, Yamamoto D, Kaji E, Omura S. Synthetic applications of a three-component Mannich reaction. Total synthesis of IL-6 inhibitor (+)-madindoline A and B Tetrahedron Letters. 47: 6761-6764. DOI: 10.1016/J.Tetlet.2006.07.083 |
0.323 |
|
| 2006 |
Shirahata T, Sunazuka T, Yoshida K, Yamamoto D, Harigaya Y, Kuwajima I, Nagai T, Kiyohara H, Yamada H, Omura S. Total synthesis, elucidation of absolute stereochemistry, and adjuvant activity of trihydroxy fatty acids Tetrahedron. 62: 9483-9496. DOI: 10.1016/J.Tet.2006.06.088 |
0.37 |
|
| 2005 |
Sunazuka T, Omura S. Total synthesis of alpha-pyrone meroterpenoids, novel bioactive microbial metabolites. Chemical Reviews. 105: 4559-80. PMID 16351054 DOI: 10.1021/cr040628i |
0.411 |
|
| 2005 |
Gouda H, Sunazuka T, Ui H, Handa M, Sakoh Y, Iwai Y, Hirono S, Omura S. Stereostructure of luminamicin, an anaerobic antibiotic, via molecular dynamics, NMR spectroscopy, and the modified Mosher method. Proceedings of the National Academy of Sciences of the United States of America. 102: 18286-91. PMID 16344486 DOI: 10.1073/Pnas.0508425102 |
0.475 |
|
| 2005 |
Matsui H, Eguchi M, Ohsumi K, Nakamura A, Isshiki Y, Sekiya K, Kikuchi Y, Nagamitsu T, Masuma R, Sunazuka T, Omura S. Azithromycin inhibits the formation of flagellar filaments without suppressing flagellin synthesis in Salmonella enterica serovar typhimurium. Antimicrobial Agents and Chemotherapy. 49: 3396-403. PMID 16048953 DOI: 10.1128/Aac.49.8.3396-3403.2005 |
0.482 |
|
| 2005 |
Yoshida K, Sunazuka T, Nagai K, Sugawara A, Cho A, Nagamitsu T, Harigaya Y, Otoguro K, Akagawa KS, Omura S. Macrolides with promotive activity of monocyte to macrophage differentiation. The Journal of Antibiotics. 58: 79-81. PMID 15813186 DOI: 10.1038/ja.2005.11 |
0.39 |
|
| 2005 |
Sunazuka T, Shirahata T, Tsuchiya S, Hirose T, Mori R, Harigaya Y, Kuwajima I, Omura S. A concise stereoselective route to the indoline spiroaminal framework of neoxaline and oxaline. Organic Letters. 7: 941-3. PMID 15727480 DOI: 10.1021/Ol050077Y |
0.541 |
|
| 2005 |
Sunazuka T, Yoshida K, Kojima N, Shirahata T, Hirose T, Handa M, Yamamoto D, Harigaya Y, Kuwajima I, Omura S. Total synthesis of (-)-physovenine from (-)-3a-hydroxyfuroindoline Tetrahedron Letters. 46: 1459-1461. DOI: 10.1016/J.Tetlet.2005.01.016 |
0.317 |
|
| 2005 |
Hirose T, Sunazuka T, Yamamoto D, Kojima N, Shirahata T, Harigaya Y, Kuwajima I, Omura S. Determination of the absolute stereochemistry and asymmetric total synthesis of madindolines A and B: A practical improvement to a second-generation approach from the first-generation Tetrahedron. 61: 6015-6039. DOI: 10.1016/J.Tet.2005.04.056 |
0.403 |
|
| 2005 |
Sunazuka T, Hirose T, Chikaraishi N, Harigaya Y, Hayashi M, Komiyama K, Sprengeler PA, Smith AB, Omura S. Absolute stereochemistries and total synthesis of (+)/(-)-macrosphelides, potent, orally bioavailable inhibitors of cell-cell adhesion Tetrahedron. 61: 3789-3803. DOI: 10.1016/J.Tet.2005.02.022 |
0.347 |
|
| 2004 |
Otoguro K, Ishiyama A, Kobayashi M, Sekiguchi H, Izuhara T, Sunazuka T, Tomoda H, Yamada H, Omura S. In vitro and in vivo antimalarial activities of a carbohydrate antibiotic, prumycin, against drug-resistant strains of Plasmodia. The Journal of Antibiotics. 57: 400-2. PMID 15323130 DOI: 10.7164/Antibiotics.57.400 |
0.493 |
|
| 2004 |
Nagai K, Shiomi K, Sunazuka T, Harder A, Turberg A, Omura S. Synthesis and biological evaluation of novel 4"-alkoxy avermectin derivatives. Bioorganic & Medicinal Chemistry Letters. 14: 4135-9. PMID 15261257 DOI: 10.1016/j.bmcl.2004.06.027 |
0.475 |
|
| 2004 |
Desaki M, Okazaki H, Sunazuka T, Omura S, Yamamoto K, Takizawa H. Molecular mechanisms of anti-inflammatory action of erythromycin in human bronchial epithelial cells: possible role in the signaling pathway that regulates nuclear factor-kappaB activation. Antimicrobial Agents and Chemotherapy. 48: 1581-5. PMID 15105108 DOI: 10.1128/Aac.48.5.1581-1585.2004 |
0.478 |
|
| 2004 |
Nagai K, Sunazuka T, Omura S. Synthesis of 4″-alkoxy avermectin derivatives using rhodium carbenoid-mediated O-H insertion reaction Tetrahedron Letters. 45: 2507-2509. DOI: 10.1016/J.Tetlet.2004.02.007 |
0.316 |
|
| 2004 |
Sunazuka T, Handa M, Nagai K, Shirahata T, Harigaya Y, Otoguro K, Kuwajima I, Omura S. Absolute stereochemistries and total synthesis of (+)-arisugacins a and B, potent, orally bioactive and selective inhibitors of acetylcholinesterase Tetrahedron. 60: 7845-7859. DOI: 10.1016/J.Tet.2004.06.059 |
0.355 |
|
| 2003 |
Takahashi T, Kusaka S, Doi T, Sunazuka T, Omura S. A combinatorial synthesis of a macrosphelide library utilizing a palladium-catalyzed carbonylation on a polymer support. Angewandte Chemie (International Ed. in English). 42: 5230-4. PMID 14601180 DOI: 10.1002/Anie.200352229 |
0.476 |
|
| 2003 |
Nagai K, Sunazuka T, Shiomi K, Harder A, Turberg A, Omura S. Synthesis and biological activities of novel 4"-alkylidene avermectin derivatives. Bioorganic & Medicinal Chemistry Letters. 13: 3943-6. PMID 14592480 DOI: 10.1016/J.Bmcl.2003.09.003 |
0.561 |
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| 2003 |
Handa M, Sunazuka T, Sugawara A, Harigaya Y, Otoguro K, Omura S. Total syntheses of the AChE inhibitors (-)-arisugacins F and G. The Journal of Antibiotics. 56: 730-3. PMID 14563166 DOI: 10.1002/chin.200403185 |
0.383 |
|
| 2003 |
Sunazuka T, Yoshida K, Oohori M, Otoguro K, Harigaya Y, Iwai Y, Akagawa KS, Omura S. Effect of 14-membered macrolide compounds on monocyte to macrophage differentiation. The Journal of Antibiotics. 56: 721-4. PMID 14563163 DOI: 10.7164/Antibiotics.56.721 |
0.489 |
|
| 2003 |
Shirahata T, Sunazuka T, Yoshida K, Yamamoto D, Harigaya Y, Nagai T, Kiyohara H, Yamada H, Kuwajima I, Omura S. Total synthesis and adjuvant activity of all stereoisomers of pinellic acid. Bioorganic & Medicinal Chemistry Letters. 13: 937-41. PMID 12617925 DOI: 10.1016/S0960-894X(02)01069-7 |
0.533 |
|
| 2003 |
Handa M, Ui H, Yamamoto D, Monma S, Iwai Y, Sunazuka T, Omura S. Structure determination of lustromycin, an antibiotic against anaerobic bacteria Heterocycles. 59: 497-500. DOI: 10.3987/Com-02-S74 |
0.347 |
|
| 2002 |
Hayashi M, Rho MC, Enomoto A, Fukami A, Kim YP, Kikuchi Y, Sunazuka T, Hirose T, Komiyama K, Omura S. Suppression of bone resorption by madindoline A, a novel nonpeptide antagonist to gp130. Proceedings of the National Academy of Sciences of the United States of America. 99: 14728-33. PMID 12417753 DOI: 10.1073/Pnas.232562799 |
0.467 |
|
| 2002 |
Tsuchihashi Y, Oishi K, Yoshimine H, Suzuki S, Kumatori A, Sunazuka T, Omura S, Matsushima K, Nagatake T. Fourteen-member macrolides suppress interleukin-8 production but do not promote apoptosis of activated neutrophils. Antimicrobial Agents and Chemotherapy. 46: 1101-4. PMID 11897597 DOI: 10.1128/Aac.46.4.1101-1104.2002 |
0.495 |
|
| 2002 |
Hirose T, Sunazuka T, Shirahata T, Yamamoto D, Harigaya Y, Kuwajima I, Omura S. Short total synthesis of (+)-madindolines A and B. Organic Letters. 4: 501-3. PMID 11843576 DOI: 10.1021/Ol017058I |
0.536 |
|
| 2002 |
Sunazuka T, Handa M, Nagai K, Shirahata T, Harigaya Y, Otoguro K, Kuwajima I, Omura S. The first total synthesis of (+/-)-arisugacin A, a potent, orally bioavailable inhibitor of acetylcholinesterase. Organic Letters. 4: 367-9. PMID 11820881 DOI: 10.1021/Ol017046X |
0.52 |
|
| 2002 |
Sunazuka T, Shirahata T, Yoshida K, Yamamoto D, Harigaya Y, Nagai T, Kiyohara H, Yamada H, Kuwajima I, Omura S. Total synthesis of pinellic acid, a potent oral adjuvant for nasal influenza vaccine. Determination of the relative and absolute configuration Tetrahedron Letters. 43: 1265-1268. DOI: 10.1016/S0040-4039(01)02348-6 |
0.344 |
|
| 2001 |
Omura S, Miyadera H, Ui H, Shiomi K, Yamaguchi Y, Masuma R, Nagamitsu T, Takano D, Sunazuka T, Harder A, Kölbl H, Namikoshi M, Miyoshi H, Sakamoto K, Kita K. An anthelmintic compound, nafuredin, shows selective inhibition of complex I in helminth mitochondria. Proceedings of the National Academy of Sciences of the United States of America. 98: 60-2. PMID 11120889 DOI: 10.1073/Pnas.98.1.60 |
0.321 |
|
| 2000 |
Oohori M, Otoguro K, Sunazuka T, Kunihiko S, Iwai Y, Omura S. Effect of 14-membered ring macrolide compounds on rat leucocyte chemotaxis and the structure-activity relationships. The Journal of Antibiotics. 53: 1219-22. PMID 11132971 DOI: 10.7164/Antibiotics.53.1219 |
0.324 |
|
| 2000 |
Obata R, Sunazuka T, Otoguro K, Tomoda H, Harigaya Y, Omura S. Synthetic conversion of ACAT inhibitor to acetylcholinesterase inhibitor. Bioorganic & Medicinal Chemistry Letters. 10: 1315-6. PMID 10890154 DOI: 10.1016/S0960-894X(00)00218-3 |
0.335 |
|
| 2000 |
Sunazuka T, Hirose T, Shirahata T, Harigaya Y, Hayashi M, Komiyama K, Omura S, Smith AB. Total synthesis of (+)-madindoline A and (-)-madindoline B, potent, selective inhibitors of interleukin 6. Determination of the relative and absolute configurations Journal of the American Chemical Society. 122: 2122-2123. DOI: 10.1021/Ja9938074 |
0.354 |
|
| 1997 |
Tomoda H, Kumagai H, Ogawa Y, Sunazuka T, Hashizume H, Nagashima H, Omura S. Synthesis of Four Chiral Isomers of beta-Lactone DU-6622 and Inhibition of HMG-CoA Synthase by the Specific (2R,3R)-Isomer. The Journal of Organic Chemistry. 62: 2161-2165. PMID 11671524 DOI: 10.1021/Jo9621433 |
0.511 |
|
| 1997 |
Matsuzaki K, Ogino T, Sunazuka T, Tanaka H, Omura S. Chloropeptins, new Anti-HIV antibiotics inhibiting gp120-CD4 binding from Streptomyces sp. II. Structure elucidation of chloropeptin I Journal of Antibiotics. 50: 66-69. PMID 9066768 DOI: 10.7164/Antibiotics.50.66 |
0.306 |
|
| 1997 |
Sunazuka T, Hirose T, Harigaya Y, Takamatsu S, Hayashi M, Komiyama K, Omura S, Sprengeler PA, Smith AB. Relative and absolute stereochemistries and total synthesis of (+)-macrosphelides A and B, potent, orally bioavailable inhibitors of cell-cell adhesion Journal of the American Chemical Society. 119: 10247-10248. DOI: 10.1021/Ja971657W |
0.323 |
|
| 1996 |
Obata R, Sunazuka T, Li Z, Tian Z, Harigaya Y, Tabata N, Tomoda H, Omura S. Chemical modification and structure-activity relationships of pyripyropenes. 1. Modification at the four hydroxyl groups Journal of Antibiotics. 49: 1133-1148. PMID 8982343 DOI: 10.7164/Antibiotics.49.1133 |
0.32 |
|
| 1996 |
Uchida R, Shiomi K, Sunazuka T, Inokoshi J, Nishizawa AI, Hirose T, Tanaka H, Iwai Y, Omura S. Kurasoins a and b, new protein farnesyltransferase inhibitors produced by Paecilomyces sp. FO-3684. II. Structure elucidation and total synthesis Journal of Antibiotics. 49: 886-889. PMID 8931722 DOI: 10.7164/Antibiotics.49.886 |
0.37 |
|
| 1996 |
Takamatsu S, Kim YP, Komiya T, Sunazuka T, Hayashi M, Tanaka H, Komiyama K, Omura S. Chlovalicin, a new cytocidal antibiotic produced by Sporothrix sp. FO-4649. II. Physicochemical properties and structural elucidation Journal of Antibiotics. 49: 635-638. PMID 8784422 DOI: 10.7164/Antibiotics.49.635 |
0.341 |
|
| 1996 |
Uchida R, Shiomi K, Inokoshi J, Sunazuka T, Tanaka H, Iwai Y, Takayanagi H, Omura S. Andrastins A∼C, new protein farnesyltransferase inhibitors produced by Penicillium sp. FO-3929: II. Structure elucidation and biosynthesis Journal of Antibiotics. 49: 418-424. PMID 8682717 DOI: 10.7164/Antibiotics.49.418 |
0.316 |
|
| 1996 |
Nagamitsu T, Sunazuka T, Tanaka H, Omura S, Sprengeler PA, Smith AB. Total synthesis of (+)-lactacystin Journal of the American Chemical Society. 118: 3584-3590. DOI: 10.1021/Ja9541544 |
0.365 |
|
| 1996 |
Yamada R, Fukuda K, Kawanishi M, Ohmori Y, Nasu M, Seto M, Sasaki Y, Sunazuka T, Zhuorong L, Funato N, Iguchi M, Harigaya Y, Iwai Y, Omura S. Synthesis and activity of staurosporine analogs with a lactone functionality Bioorganic and Medicinal Chemistry Letters. 6: 1893-1896. DOI: 10.1016/0960-894X(96)00343-5 |
0.368 |
|
| 1994 |
Kim YK, Tomoda H, Nishida H, Sunazuka T, Obata R, Omura S. Pyripyropenes, novel inhibitors of acyl-CoA: Cholesterol acyltransferase produced by Aspergillus fumigatus. II. Structure elucidation of pyripyropenes A, B, C and D Journal of Antibiotics. 47: 154-162. PMID 8150710 DOI: 10.7164/Antibiotics.47.154 |
0.305 |
|
| 1994 |
Hashizume H, Ito H, Morikawa T, Kanaya N, Nagashima H, Usui H, Tomoda H, Sunazuka T, Kumagai H, Omura S. Synthesis and biological activity of new 3-hydroxy-3-methylglutaryl-CoA synthase inhibitors: 3-Oxetanones with a side chain mimicking the extended structure of 1233A Chemical and Pharmaceutical Bulletin. 42: 2097-2107. PMID 7805135 DOI: 10.1248/Cpb.42.2097 |
0.382 |
|
| 1993 |
Sunazuka T, Tabata N, Nagamitsu T, Tomoda H, Omura S. Synthesis of diolmycin analogs and their anticoccidial activities [5] Journal of Antibiotics. 46: 1178-1180. PMID 8360116 DOI: 10.7164/Antibiotics.46.1178 |
0.388 |
|
| 1993 |
Sunazuka T, Tabata N, Nagamitsu T, Tomoda H, Omura S, Smith AB. Asymmetric synthesis of the anticoccidial antibiotic diolmycin A1. Determination of absolute stereochemistry Tetrahedron Letters. 34: 6659-6660. DOI: 10.1016/S0040-4039(00)61668-4 |
0.329 |
|
| 1993 |
Sunazuka T, Nagamitsu T, Tanaka H, Omura S, Sprengeler PA, Smith AB. An efficient asymmetric synthesis of the four stereoisomers of 3-hydroxyleucine Tetrahedron Letters. 34: 4447-4448. DOI: 10.1016/0040-4039(93)88055-N |
0.357 |
|
| 1992 |
Sunazuka T, Tsuzuki K, Kumagai H, Tomoda H, Tanaka H, Nagashima H, Hashizume H, Omura S. Synthesis of 1233A analogs and their inhibitory activity against hydroxymethylglutaryl coenzyme a synthase Journal of Antibiotics. 45: 1139-1147. PMID 1355474 DOI: 10.7164/Antibiotics.45.1139 |
0.359 |
|
| 1992 |
Smith AB, Kingery-Wood J, Leenay TL, Nolen EG, Sunazuka T. Indole diterpene synthetic studies. 8. The total synthesis of (+)-paspalicine and (+)-paspalinine Journal of the American Chemical Society. 114: 1438-1449. DOI: 10.1021/Ja00030A046 |
0.36 |
|
| 1990 |
Smith AB, Sunazuka T, Leenay TL, Kingery-Wood J. Total synthesis of (+)-paspalicine and (+)-paspalinine Journal of the American Chemical Society. 112: 8197-8198. DOI: 10.1021/Ja00178A071 |
0.334 |
|
| 1989 |
Sunazuka T, Tsuzuki K, Marui S, Toyoda H, Omura S, Inatomi N, Itoh Z. Motilides, macrolides with gastrointestinal motor stimulating activity. II. Quaternary N-substituted derivatives of 8,9-anhydroerythromycin a 6,9-hemiacetal and 9,9-dihydroerythromycin A 6,9-epoxide Chemical and Pharmaceutical Bulletin. 37: 2701-2709. PMID 2611929 DOI: 10.1248/Cpb.37.2701 |
0.34 |
|
| 1989 |
Tsuzuki K, Sunazuka T, Marui S, Toyoda H, Omura S, Inatomi N, Itoh Z. Motilides, macrolides with gastrointestinal motor stimulating activity. I. O-substituted and tertiary N-substituted derivatives of 8,9-anhydroerythromycin A 6,9-hemiacetal Chemical and Pharmaceutical Bulletin. 37: 2687-2700. PMID 2611928 DOI: 10.1248/Cpb.37.2687 |
0.332 |
|
| 1984 |
Sano H, Sunazuka T, Tanaka H, Yamashita K, Okachi R, Omura S. Chemical modification of spiramycins. IV. Synthesis and in vitro and in vivo activities of 3'',4''-diacylates and 3,3''-4''-triacylates of spiramycin I Journal of Antibiotics. 37: 760-772. PMID 6469870 DOI: 10.7164/Antibiotics.37.760 |
0.3 |
|
| 1984 |
Sano H, Sunazuka T, Tanaka H, Yamashita K, Okachi R, Omura S. Chemical modification of spiramycins. III. Synthesis and antibacterial activities of 4'-sulfonates and 4'-alkylethers of spiramycin I Journal of Antibiotics. 37: 750-759. PMID 6469869 DOI: 10.7164/Antibiotics.37.750 |
0.347 |
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