Brendan D. Manning, Ph.D.
Affiliations: | 2000 | Yale University, New Haven, CT |
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"Brendan Manning"Parents
Sign in to add mentor| Michael Snyder | grad student | 2000 | Yale | |
| (The genetic, cytological, and biochemical analyses of Cik1p and Vik1p, two regulators of a multifunctional kinesin.) | ||||
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Publications
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| Cormerais Y, Lapp SC, Kalafut KC, et al. (2024) AKT-mediated phosphorylation of TSC2 controls stimulus- and tissue-specific mTORC1 signaling and organ growth. Biorxiv : the Preprint Server For Biology |
| Manning BD, Dibble CC. (2024) Growth Signaling Networks Orchestrate Cancer Metabolic Networks. Cold Spring Harbor Perspectives in Medicine |
| Hosios AM, Wilkinson ME, McNamara MC, et al. (2022) mTORC1 regulates a lysosome-dependent adaptive shift in intracellular lipid species. Nature Metabolism. 4: 1792-1811 |
| Soflaee MH, Kesavan R, Sahu U, et al. (2022) Purine nucleotide depletion prompts cell migration by stimulating the serine synthesis pathway. Nature Communications. 13: 2698 |
| Hosios AM, Manning BD. (2021) Cancer Signaling Drives Cancer Metabolism: AKT and the Warburg Effect. Cancer Research. 81: 4896-4898 |
| Byles V, Cormerais Y, Kalafut K, et al. (2021) Hepatic mTORC1 signaling activates ATF4 as part of its metabolic response to feeding and insulin. Molecular Metabolism. 101309 |
| Torrence ME, MacArthur MR, Hosios AM, et al. (2021) The mTORC1-mediated activation of ATF4 promotes protein and glutathione synthesis downstream of growth signals. Elife. 10 |
| Valvezan AJ, McNamara MC, Miller SK, et al. (2020) IMPDH inhibitors for antitumor therapy in tuberous sclerosis complex. Jci Insight. 5 |
| Valvezan AJ, Manning BD. (2019) Molecular logic of mTORC1 signalling as a metabolic rheostat. Nature Metabolism. 1: 321-333 |
| Hoxhaj G, Manning BD. (2019) The PI3K-AKT network at the interface of oncogenic signalling and cancer metabolism. Nature Reviews. Cancer |