Reid M. McCarty, Ph.D.

Affiliations: 
2011 Biochemistry University of Arizona, Tucson, AZ 
Area:
Biochemistry
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"Reid McCarty"
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Vahe Bandarian grad student 2011 University of Arizona
 (Elucidation of the biosynthetic pathway for 7-deazapurines.)
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Publications

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Kim HJ, Liu YN, McCarty RM, et al. (2017) Reaction Catalyzed by GenK, a Cobalamin-Dependent Radical SAM Methyltransferase in the Biosynthetic Pathway of Gentamicin, Proceeds with Retention of Configuration. Journal of the American Chemical Society
Bruender NA, Grell TA, Dowling DP, et al. (2017) 7-Carboxy-7-deazaguanine synthase - A radical S-adenosyl-L-methionine enzyme with polar tendencies. Journal of the American Chemical Society
Miles ZD, Roberts SA, McCarty RM, et al. (2014) Biochemical and structural studies of 6-carboxy-5,6,7,8-tetrahydropterin synthase reveal the molecular basis of catalytic promiscuity within the tunnel-fold superfamily. The Journal of Biological Chemistry. 289: 23641-52
Nelp MT, Astashkin AV, Breci LA, et al. (2014) The alpha subunit of nitrile hydratase is sufficient for catalytic activity and post-translational modification. Biochemistry. 53: 3990-4
Dowling DP, Bruender NA, Young AP, et al. (2014) Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism. Nature Chemical Biology. 10: 106-12
Kim HJ, McCarty RM, Ogasawara Y, et al. (2013) GenK-catalyzed C-6' methylation in the biosynthesis of gentamicin: isolation and characterization of a cobalamin-dependent radical SAM enzyme. Journal of the American Chemical Society. 135: 8093-6
McCarty RM, Krebs C, Bandarian V. (2013) Spectroscopic, steady-state kinetic, and mechanistic characterization of the radical SAM enzyme QueE, which catalyzes a complex cyclization reaction in the biosynthesis of 7-deazapurines. Biochemistry. 52: 188-98
McCarty RM, Bandarian V. (2012) Biosynthesis of pyrrolopyrimidines. Bioorganic Chemistry. 43: 15-25
Jenkins JL, Krucinska J, McCarty RM, et al. (2011) Comparison of a preQ1 riboswitch aptamer in metabolite-bound and free states with implications for gene regulation. The Journal of Biological Chemistry. 286: 24626-37
Miles ZD, McCarty RM, Molnar G, et al. (2011) Discovery of epoxyqueuosine (oQ) reductase reveals parallels between halorespiration and tRNA modification. Proceedings of the National Academy of Sciences of the United States of America. 108: 7368-72
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