Patrick C. Bradshaw, PhD

2015- Department of Biomedical Sciences East Tennessee State University - Quillen School of Medicine 
mitochondrial function, aging, neurodegeneration
"Patrick Bradshaw"

Dr. Bradshaw grew up in East Peoria, IL, attended the University of Illinois for his B.S. degree, majoring in bioengineering and chemistry. He went on to earn a PhD in biochemistry at Ohio State University followed by postdoctoral research at the University of Missouri-Columbia, Virginia Tech, and the University of Wisconsin Madison. He was a faculty member at the University of South Florida from 2008-2015.

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Delic V, Noble K, Zivkovic S, et al. (2018) The effects of AICAR and rapamycin on mitochondrial function in immortalized mitochondrial DNA mutator murine embryonic fibroblasts. Biology Open
Delic V, Griffin JWD, Zivkovic S, et al. (2017) Individual Amino Acid Supplementation Can Improve Energy Metabolism and Decrease ROS Production in Neuronal Cells Overexpressing Alpha-Synuclein. Neuromolecular Medicine
Sawmiller D, Li S, Mori T, et al. (2017) Beneficial effects of a pyrroloquinolinequinone-containing dietary formulation on motor deficiency, cognitive decline and mitochondrial dysfunction in a mouse model of Alzheimer's disease. Heliyon. 3: e00279
Griffin JW, Bradshaw PC. (2017) Amino Acid Catabolism in Alzheimer's Disease Brain: Friend or Foe? Oxidative Medicine and Cellular Longevity. 2017: 5472792
Copes N, Edwards C, Chaput D, et al. (2015) Metabolome and proteome changes with aging in Caenorhabditis elegans. Experimental Gerontology. 72: 67-84
O'Neal-Moffitt G, Delic V, Bradshaw PC, et al. (2015) Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in AβPP(swe)/PS1 mice. Molecular Neurodegeneration. 10: 27
Delic V, Brownlow M, Joly-Amado A, et al. (2015) Calorie restriction does not restore brain mitochondrial function in P301L tau mice, but it does decrease mitochondrial F0F1-ATPase activity. Molecular and Cellular Neurosciences. 67: 46-54
Edwards C, Copes N, Bradshaw PC. (2015) D-ß-hydroxybutyrate: an anti-aging ketone body. Oncotarget. 6: 3477-8
Edwards C, Canfield J, Copes N, et al. (2015) Mechanisms of amino acid-mediated lifespan extension in Caenorhabditis elegans. Bmc Genetics. 16: 8
Edwards C, Canfield J, Copes N, et al. (2014) D-beta-hydroxybutyrate extends lifespan in C. elegans. Aging. 6: 621-44
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