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Nick A. Paras - Publications

Affiliations: 
University of California, San Francisco, San Francisco, CA 
Area:
Medicinal Chemistry
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17/25 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Conrad J, Paras NA, Vaz RJ. Model of P-Glycoprotein Ligand Binding and Validation with Efflux Substrate Matched Pairs. Journal of Medicinal Chemistry. 67: 5854-5865. PMID 38544305 DOI: 10.1021/acs.jmedchem.4c00139  0.412
2022 Wong DR, Conrad J, Johnson N, Ayers J, Laeremans A, Lee JC, Lee J, Prusiner SB, Bandyopadhyay S, Butte AJ, Paras NA, Keiser MJ. Trans-channel fluorescence learning improves high-content screening for Alzheimer's disease therapeutics. Nature Machine Intelligence. 4: 583-595. PMID 36276634 DOI: 10.1038/s42256-022-00490-8  0.421
2021 Nguyen TH, O'Brien CJ, Tran MLN, Olson SH, Settineri NS, Prusiner SB, Paras NA, Conrad J. Water-Soluble Iridium Photoredox Catalyst for the Trifluoromethylation of Biomolecule Substrates in Phosphate Buffered Saline Solvent. Organic Letters. PMID 33929208 DOI: 10.1021/acs.orglett.1c00871  0.48
2021 Lozano C, Ramirez C, Sin N, Viart HM, Prusiner SB, Paras NA, Conrad J. Silver Benzoate Facilitates the Copper-Catalyzed C-N Coupling of Iodoazoles with Aromatic Nitrogen Heterocycles. Acs Omega. 6: 9804-9812. PMID 33869960 DOI: 10.1021/acsomega.1c00458  0.52
2020 Li Y, Vaz RJ, Olson SH, Munson M, Paras NA, Conrad J. Selectivity in the Addition of Electron Deficient Radicals to the 2 Position of Indoles. European Journal of Organic Chemistry. 2020: 5828-5832. PMID 33692651 DOI: 10.1002/Ejoc.201901784  0.476
2020 Grandjean JM, Jiu AY, West JW, Aoyagi A, Droege DG, Elepano M, Hirasawa M, Hirouchi M, Murakami R, Lee J, Sasaki K, Hirano S, Ohyama T, Tang BC, Vaz RJ, ... ... Paras NA, et al. Discovery of 4-Piperazine Isoquinoline Derivatives as Potent and Brain-Permeable Tau Prion Inhibitors with CDK8 Activity. Acs Medicinal Chemistry Letters. 11: 127-132. PMID 32071678 DOI: 10.1021/Acsmedchemlett.9B00480  0.476
2018 Caenepeel S, Brown SP, Belmontes B, Moody G, Keegan KS, Chui D, Whittington DA, Huang X, Poppe L, Cheng AC, Cardozo M, Houze J, Li Y, Lucas B, Paras NA, et al. AMG 176, a Selective MCL1 Inhibitor, is Effective in Hematological Cancer Models Alone and in Combination with Established Therapies. Cancer Discovery. PMID 30254093 DOI: 10.1158/2159-8290.Cd-18-0387  0.48
2018 O'Brien CJ, Droege DG, Jiu AY, Gandhi SS, Paras NA, Olson SH, Conrad J. Photoredox Cyanomethylation of Indoles: Catalyst Modification and Mechanism. The Journal of Organic Chemistry. PMID 29940725 DOI: 10.1021/Acs.Joc.8B01146  0.599
2014 Johnson MG, Gribble MW, Houze JB, Paras NA. Convenient route to secondary sulfinates: application to the stereospecific synthesis of α-C-chiral sulfonamides. Organic Letters. 16: 6248-51. PMID 25415837 DOI: 10.1021/Ol503208Z  0.386
2010 EVANS DA, BURGEY CS, PARAS NA, VOJKOVSKY T, TREGAY SW. ChemInform Abstract: C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Enantioselective Catalysis of the Glyoxylate-Ene Reaction. Cheminform. 29: no-no. DOI: 10.1002/chin.199844036  0.526
2009 Paras NA, Simmons B, MacMillan DWC. A process for the rapid removal of dialkylamino-substituents from aromatic rings. Application to the expedient synthesis of (R)-tolterodine Tetrahedron. 65: 3232-3238. DOI: 10.1016/J.Tet.2008.12.054  0.59
2004 Bunin BA, Dener JM, Kelly DE, Paras NA, Tario JD, Tushup SP. Solid-phase synthesis of 1-substituted tetrahydroisoquinoline derivatives employing BOC-protected tetrahydroisoquinoline carboxylic acids. Journal of Combinatorial Chemistry. 6: 487-96. PMID 15244409 DOI: 10.1021/Cc0340776  0.398
2002 Paras NA, MacMillan DW. The enantioselective organocatalytic 1,4-addition of electron-rich benzenes to alpha,beta-unsaturated aldehydes. Journal of the American Chemical Society. 124: 7894-5. PMID 12095321 DOI: 10.1021/Ja025981P  0.621
2001 Paras NA, MacMillan DW. New strategies in organic catalysis: the first enantioselective organocatalytic Friedel-Crafts alkylation. Journal of the American Chemical Society. 123: 4370-1. PMID 11457218 DOI: 10.1021/Ja015717G  0.617
2000 Evans DA, Tregay SW, Burgey CS, Paras NA, Vojkovsky T. C2-symmetric copper(II) complexes as chiral lewis acids. Catalytic enantioselective carbonyl - Ene reactions with glyoxylate and pyruvate esters Journal of the American Chemical Society. 122: 7936-7943. DOI: 10.1021/Ja000913T  0.553
2000 Evans DA, Tregay SW, Burgey CS, Paras NA, Vojkovsky T. ChemInform Abstract: C2-Symmetric Copper(II) Complexes as Chiral Lewis Acids. Catalytic Enantioselective Carbonyl-Ene Reactions with Glyoxylate and Pyruvate Esters. Cheminform. 31: no-no. DOI: 10.1002/chin.200049032  0.547
1998 Evans DA, Burgey CS, Paras NA, Vojkovsky T, Tregay SW. C2-symmetric copper(II) complexes as chiral Lewis acids. Enantioselective catalysis of the glyoxylate - Ene reaction [10] Journal of the American Chemical Society. 120: 5824-5825. DOI: 10.1021/Ja980549M  0.602
Low-probability matches (unlikely to be authored by this person)
2009 Smith AL, DeMorin FF, Paras NA, Huang Q, Petkus JK, Doherty EM, Nixey T, Kim JL, Whittington DA, Epstein LF, Lee MR, Rose MJ, Babij C, Fernando M, Hess K, et al. Selective inhibitors of the mutant B-Raf pathway: discovery of a potent and orally bioavailable aminoisoquinoline. Journal of Medicinal Chemistry. 52: 6189-92. PMID 19764794 DOI: 10.1021/Jm901081G  0.256
2010 Kim JL, Smith AL, Carnahan J, Beltran PJ, Whittington DA, Rose MJ, DeMorin F, Doherty E, Huang Q, Ncube M, Paras NA, Petkus JK, Tasker AS, Lee MR, Babij C, et al. Abstract 2681A: Structure-guided design of potent and selective inhibitors of B-Raf kinase displaying on-mechanismin vivoactivity Cancer Research. 70. DOI: 10.1158/1538-7445.Am10-2681A  0.227
2016 Geschwind MD, Paras N. Deutetrabenazine for Treatment of Chorea in Huntington Disease. Jama. 316: 33-5. PMID 27380339 DOI: 10.1001/Jama.2016.8011  0.183
2010 Paras NA, MacMillan DWC. ChemInform Abstract: The Enantioselective Organocatalytic 1,4-Addition of Electron-Rich Benzenes to α,β-Unsaturated Aldehydes. Cheminform. 33: no-no. DOI: 10.1002/chin.200244032  0.179
2020 Ayers JI, Paras NA, Prusiner SB. Expanding spectrum of prion diseases. Emerging Topics in Life Sciences. 4: 155-167. PMID 32803268 DOI: 10.1042/ETLS20200037  0.126
2023 Merz GE, Chalkley MJ, Tan SK, Tse E, Lee J, Prusiner SB, Paras NA, DeGrado WF, Southworth DR. Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments. Nature Communications. 14: 3048. PMID 37236970 DOI: 10.1038/s41467-023-38537-y  0.118
2022 Ayers JI, Lee J, Monteiro O, Woerman AL, Lazar AA, Condello C, Paras NA, Prusiner SB. Different α-synuclein prion strains cause dementia with Lewy bodies and multiple system atrophy. Proceedings of the National Academy of Sciences of the United States of America. 119. PMID 35115402 DOI: 10.1073/pnas.2113489119  0.08
2021 Kim GJ, Mo H, Liu H, Wu Z, Chen S, Zheng J, Zhao X, Nucum D, Shortland J, Peng L, Elepano M, Tang B, Olson S, Paras N, Li H, et al. A zebrafish screen reveals Renin-angiotensin system inhibitors as neuroprotective via mitochondrial restoration in dopamine neurons. Elife. 10. PMID 34550070 DOI: 10.7554/eLife.69795  0.072
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