Year |
Citation |
Score |
2024 |
Rochon K, Bauer BL, Roethler NA, Buckley Y, Su CC, Huang W, Ramachandran R, Stoll MSK, Yu EW, Taylor DJ, Mears JA. Structural basis for regulated assembly of the mitochondrial fission GTPase Drp1. Nature Communications. 15: 1328. PMID 38351080 DOI: 10.1038/s41467-024-45524-4 |
0.482 |
|
2024 |
Pérez-Jover I, Rochon K, Hu D, Mahajan M, Madan Mohan P, Santos-Pérez I, Ormaetxea Gisasola J, Martinez Galvez JM, Agirre J, Qi X, Mears JA, Shnyrova AV, Ramachandran R. Allosteric control of dynamin-related protein 1 through a disordered C-terminal Short Linear Motif. Nature Communications. 15: 52. PMID 38168038 DOI: 10.1038/s41467-023-44413-6 |
0.376 |
|
2023 |
Pérez-Jover I, Rochon K, Hu D, Mohan PM, Santos-Perez I, Gisasola JO, Galvez JMM, Agirre J, Qi X, Mears JA, Shnyrova AV, Ramachandran R. Allosteric control of dynamin-related protein 1-catalyzed mitochondrial fission through a conserved disordered C-terminal Short Linear Motif. Research Square. PMID 37503116 DOI: 10.21203/rs.3.rs-3161608/v1 |
0.391 |
|
2023 |
Bauer BL, Rochon K, Liu JC, Ramachandran R, Mears JA. Disease-associated mutations in Drp1 have fundamentally different effects on the mitochondrial fission machinery. Human Molecular Genetics. PMID 36795043 DOI: 10.1093/hmg/ddad029 |
0.327 |
|
2023 |
Robertson GL, Riffle S, Patel M, Bodnya C, Marshall A, Beasley HK, Garza-Lopez E, Shao J, Vue Z, Hinton A, Stoll MS, de Wet S, Theart RP, Chakrabarty RP, Loos B, ... ... Mears JA, et al. DRP1 mutations associated with EMPF1 encephalopathy alter mitochondrial membrane potential and metabolic programs. Journal of Cell Science. 136. PMID 36763487 DOI: 10.1242/jcs.260370 |
0.351 |
|
2022 |
Mears JA, Ramachandran R. Drp1 and the cytoskeleton: mechanistic nexus in mitochondrial division. Current Opinion in Physiology. 29. PMID 36406887 DOI: 10.1016/j.cophys.2022.100574 |
0.316 |
|
2021 |
Akinbiyi EO, Abramowitz LK, Bauer BL, Stoll MSK, Hoppel CL, Hsiao CP, Hanover JA, Mears JA. Blocked O-GlcNAc cycling alters mitochondrial morphology, function, and mass. Scientific Reports. 11: 22106. PMID 34764359 DOI: 10.1038/s41598-021-01512-y |
0.325 |
|
2020 |
Montecinos-Franjola F, Bauer BL, Mears JA, Ramachandran R. GFP fluorescence tagging alters dynamin-related protein 1 oligomerization dynamics and creates disassembly-refractory puncta to mediate mitochondrial fission. Scientific Reports. 10: 14777. PMID 32901052 DOI: 10.1038/S41598-020-71655-X |
0.482 |
|
2020 |
Clinton RW, Bauer BL, Mears JA. Affinity Purification and Functional Characterization of Dynamin-Related Protein 1. Methods in Molecular Biology (Clifton, N.J.). 2159: 41-53. PMID 32529362 DOI: 10.1007/978-1-0716-0676-6_4 |
0.444 |
|
2020 |
Hoppins S, Lackner LL, Lee JE, Mears JA. In vitro and in vivo assays for mitochondrial fission and fusion. Methods in Cell Biology. 155: 491-518. PMID 32183974 DOI: 10.1016/Bs.Mcb.2019.11.010 |
0.447 |
|
2020 |
Whiddon K, Clinton R, Mears J. Investigating Interactions in the Drp1-Mff Copolymer That Contributes to Mitochondrial Fission Microscopy and Microanalysis. 1-3. DOI: 10.1017/S1431927620017663 |
0.43 |
|
2020 |
Rochon K, Blanco AT, Mears J. Conformational Changes in Solution Multimers of Dynamin-related Protein 1 (Drp1) Facilitate Functional Assembly Microscopy and Microanalysis. 1-2. DOI: 10.1017/S1431927620015895 |
0.376 |
|
2019 |
Tiosano D, Mears JA, Buchner DA. Mitochondrial Dysfunction in Primary Ovarian Insufficiency. Endocrinology. PMID 31393557 DOI: 10.1210/En.2019-00441 |
0.391 |
|
2019 |
Rochon K, Mears JA. Determining the Solution Structure of the Drp1 and its Role in the Assembly of the Mitochondrial Fission Machinery Microscopy and Microanalysis. 25: 1322-1323. DOI: 10.1017/S1431927619007347 |
0.462 |
|
2019 |
Whiddon KT, Clinton RW, Mears JA. Elucidating Molecular Mechanisms of Mitochondrial Fission Machinery via Helical Studies of Drp1 and its Partner Proteins Microscopy and Microanalysis. 25: 1320-1321. DOI: 10.1017/S1431927619007335 |
0.469 |
|
2018 |
Lu B, Kennedy B, Clinton RW, Wang EJ, McHugh D, Stepanyants N, Macdonald PJ, Mears JA, Qi X, Ramachandran R. Steric interference from intrinsically disordered regions controls dynamin-related protein 1 self-assembly during mitochondrial fission. Scientific Reports. 8: 10879. PMID 30022112 DOI: 10.1038/S41598-018-29001-9 |
0.547 |
|
2018 |
Tandler B, Hoppel CL, Mears JA. Morphological Pathways of Mitochondrial Division. Antioxidants (Basel, Switzerland). 7. PMID 29462856 DOI: 10.3390/Antiox7020030 |
0.511 |
|
2018 |
Mears JA, Francy CA, Clinton RW, Lee S. Structural Studies that Define Regulatory Interactions Within the Mitochondrial Fission Machinery Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.2066 |
0.477 |
|
2017 |
Francy CA, Clinton RW, Fröhlich C, Murphy C, Mears JA. Cryo-EM Studies of Drp1 Reveal Cardiolipin Interactions that Activate the Helical Oligomer. Scientific Reports. 7: 10744. PMID 28878368 DOI: 10.1038/S41598-017-11008-3 |
0.542 |
|
2017 |
Clinton RW, Mears JA. Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro. Journal of Visualized Experiments : Jove. PMID 28117823 DOI: 10.3791/54971 |
0.474 |
|
2017 |
Clinton RW, Francy CA, Mears JA. Structural Studies that Define Regulatory Interactions within the Mitochondrial Fission Machinery Microscopy and Microanalysis. 23: 1244-1245. DOI: 10.1017/S1431927617006882 |
0.477 |
|
2016 |
Francy CA, Frohlich C, Daumke O, Mears JA. Defining Membrane Interactions that Drive Dynamin Related Protein 1 (Drp1) Oligomerization using cryo-EM Biophysical Journal. 110. DOI: 10.1016/J.Bpj.2015.11.882 |
0.567 |
|
2016 |
Clinton RW, Ramachandran R, Mears JA. Mitochondrial Recruitment of Drp1 by Mff is Opposed by the Variable Domain Biophysical Journal. 110: 216. DOI: 10.1016/J.Bpj.2015.11.1201 |
0.558 |
|
2015 |
Clinton RW, Francy CA, Ramachandran R, Qi X, Mears JA. Dynamin-Related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-Anchored Mitochondrial Fission Factor. The Journal of Biological Chemistry. PMID 26578514 DOI: 10.1074/Jbc.M115.680025 |
0.562 |
|
2015 |
Macdonald PJ, Francy CA, Stepanyants N, Lehman L, Baglio A, Mears JA, Qi X, Ramachandran R. Distinct Splice Variants of Dynamin-related Protein 1 Differentially Utilize Mitochondrial Fission Factor as an Effector of Cooperative GTPase Activity. The Journal of Biological Chemistry. PMID 26578513 DOI: 10.1074/Jbc.M115.680181 |
0.51 |
|
2015 |
Stepanyants N, Macdonald PJ, Francy CA, Mears JA, Qi X, Ramachandran R. Cardiolipin's propensity for phase transition and its reorganization by dynamin-related protein 1 form a basis for mitochondrial membrane fission. Molecular Biology of the Cell. PMID 26157169 DOI: 10.1091/Mbc.E15-06-0330 |
0.514 |
|
2015 |
Francy CA, Alvarez FJ, Zhou L, Ramachandran R, Mears JA. The mechanoenzymatic core of dynamin-related protein 1 comprises the minimal machinery required for membrane constriction. The Journal of Biological Chemistry. 290: 11692-703. PMID 25770210 DOI: 10.1074/Jbc.M114.610881 |
0.53 |
|
2015 |
Francy CA, Alvarez FJD, Zhou L, Mears JA. The Mechanoenzymatic Properties of Drp1 in Nucleotide Induced Constriction of Lipid Bilayers Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.2039 |
0.545 |
|
2014 |
Macdonald PJ, Stepanyants N, Mehrotra N, Mears JA, Qi X, Sesaki H, Ramachandran R. A dimeric equilibrium intermediate nucleates Drp1 reassembly on mitochondrial membranes for fission. Molecular Biology of the Cell. 25: 1905-15. PMID 24790094 DOI: 10.1091/Mbc.E14-02-0728 |
0.514 |
|
2014 |
Francy CA, Frölich C, Daumke O, Mears JA. Examining Drp1 Conformational Changes and Domain Interactions in the Mitochondrial Fission Complex using Cryo-Em Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.3328 |
0.537 |
|
2014 |
Alvarez FJD, Francy CA, Mears JA. Cryo-Em Studies of DRP1 Self-Assembly Provide Insights into the Mechanism of Mitochondrial Fission Biophysical Journal. 106: 5-8. DOI: 10.1016/J.Bpj.2013.11.3312 |
0.551 |
|
2013 |
Fröhlich C, Grabiger S, Schwefel D, Faelber K, Rosenbaum E, Mears J, Rocks O, Daumke O. Structural insights into oligomerization and mitochondrial remodelling of dynamin 1-like protein. The Embo Journal. 32: 1280-92. PMID 23584531 DOI: 10.1038/Emboj.2013.74 |
0.548 |
|
2013 |
Alvarez F, Zhou L, Mears JA. Structural Studies of Dynamin-Related Protein 1 (DRP1) Provide Mechanistic Insight into Mitochondrial Fission. Biophysical Journal. 104. DOI: 10.1016/J.Bpj.2012.11.1948 |
0.586 |
|
2012 |
Mears JA, Alvarez F, Zhou L, Fang S, Hinshaw J. Cryo-EM studies of dynamin-related proteins that regulate mitochondrial fission Microscopy and Microanalysis. 18: 60-61. DOI: 10.1017/S1431927612002152 |
0.472 |
|
2012 |
Alvarez FJD, Zhou L, Mears JA. Structural studies of Dnm1/Drp1 provide mechanistic insight into mitochondrial fission Mitochondrion. 12: 573-574. DOI: 10.1016/J.Mito.2012.07.060 |
0.474 |
|
2012 |
Hinshaw JE, Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Dyda F. Structural Analysis of Dynamin Reveals Power Stroke Biophysical Journal. 102: 321a. DOI: 10.1016/J.Bpj.2011.11.1764 |
0.469 |
|
2011 |
Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F. A pseudoatomic model of the dynamin polymer identifies a hydrolysis-dependent powerstroke. Cell. 147: 209-22. PMID 21962517 DOI: 10.1016/J.Cell.2011.09.003 |
0.708 |
|
2011 |
Jomaa A, Stewart G, Mears JA, Kireeva I, Brown ED, Ortega J. Cryo-electron microscopy structure of the 30S subunit in complex with the YjeQ biogenesis factor. Rna (New York, N.Y.). 17: 2026-38. PMID 21960487 DOI: 10.1261/rna.2922311 |
0.374 |
|
2011 |
Mears JA, Lackner LL, Fang S, Ingerman E, Nunnari J, Hinshaw JE. Conformational changes in Dnm1 support a contractile mechanism for mitochondrial fission. Nature Structural & Molecular Biology. 18: 20-6. PMID 21170049 DOI: 10.1038/Nsmb.1949 |
0.74 |
|
2011 |
Chappie JS, Mears JA, Fang S, Leonard M, Schmid SL, Milligan RA, Hinshaw JE, Dyda F. An Improved Model for Dynamin Assembly Revealed by Cryo-EM Biophysical Journal. 100: 324a. DOI: 10.1016/J.Bpj.2010.12.1969 |
0.498 |
|
2010 |
Mears J, Ray P, Fang S, Heymann J, Hinshaw J. Dynamin Family Members and Their Role in Membrane Remodeling Microscopy and Microanalysis. 16: 1072-1073. DOI: 10.1017/S1431927610055480 |
0.305 |
|
2009 |
Schulz TA, Choi MG, Raychaudhuri S, Mears JA, Ghirlando R, Hinshaw JE, Prinz WA. Lipid-regulated sterol transfer between closely apposed membranes by oxysterol-binding protein homologues. The Journal of Cell Biology. 187: 889-903. PMID 20008566 DOI: 10.1083/Jcb.200905007 |
0.685 |
|
2009 |
Ray P, Fang S, Mears JA, Hinshaw JE. The Role of the Proline Rich Domain in the Structural Organization of Dynamin Biophysical Journal. 96. DOI: 10.1016/J.Bpj.2008.12.295 |
0.44 |
|
2009 |
Mears JA, Lackner LL, Fang S, Nunnari JM, Hinshaw JE. Mitochondrial Fission is Mediated by Conformational Changes in the Dynamin-related Protein, Dnm1 Biophysical Journal. 96: 413a. DOI: 10.1016/J.Bpj.2008.12.2105 |
0.531 |
|
2008 |
Mears JA, Hinshaw JE. Visualization of dynamins. Methods in Cell Biology. 88: 237-56. PMID 18617037 DOI: 10.1016/S0091-679X(08)00413-5 |
0.737 |
|
2008 |
Hinshaw JE, Mears JA, Ray P, Fang S. Structural analysis of dynamin family members provide insight into membrane fission Microscopy and Microanalysis. 14: 1566-1567. DOI: 10.1017/S1431927608082846 |
0.368 |
|
2008 |
Ray P, Fang S, Mears JA, Hinshaw JE. The role of dynamin domains in membrane constriction Microscopy and Microanalysis. 14: 1318-1319. DOI: 10.1017/S1431927608081993 |
0.396 |
|
2008 |
Mears JA, Stagg SM, Harvey SC. Modeling Large RNA Assemblies using a Reduced Representation Handbook of Rna Biochemistry. 546-559. DOI: 10.1002/9783527619504.ch33 |
0.63 |
|
2007 |
Mears JA, Ray P, Hinshaw JE. A corkscrew model for dynamin constriction. Structure (London, England : 1993). 15: 1190-202. PMID 17937909 DOI: 10.1016/J.Str.2007.08.012 |
0.699 |
|
2006 |
Mears JA, Sharma MR, Gutell RR, McCook AS, Richardson PE, Caulfield TR, Agrawal RK, Harvey SC. A structural model for the large subunit of the mammalian mitochondrial ribosome. Journal of Molecular Biology. 358: 193-212. PMID 16510155 DOI: 10.1016/J.Jmb.2006.01.094 |
0.756 |
|
2005 |
Ingerman E, Perkins EM, Marino M, Mears JA, McCaffery JM, Hinshaw JE, Nunnari J. Dnm1 forms spirals that are structurally tailored to fit mitochondria. The Journal of Cell Biology. 170: 1021-7. PMID 16186251 DOI: 10.1083/Jcb.200506078 |
0.727 |
|
2004 |
Ivanov VI, Mears JA. Using Cross-links to Study Ribosomal Dynamics. Journal of Biomolecular Structure & Dynamics. 21: 691-698. PMID 22650307 DOI: 10.1080/07391102.2004.10506962 |
0.32 |
|
2003 |
Stagg SM, Mears JA, Harvey SC. A structural model for the assembly of the 30S subunit of the ribosome. Journal of Molecular Biology. 328: 49-61. PMID 12683996 DOI: 10.1016/S0022-2836(03)00174-8 |
0.697 |
|
2002 |
Mears JA, Cannone JJ, Stagg SM, Gutell RR, Agrawal RK, Harvey SC. Modeling a minimal ribosome based on comparative sequence analysis. Journal of Molecular Biology. 321: 215-34. PMID 12144780 DOI: 10.1016/S0022-2836(02)00568-5 |
0.732 |
|
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