| Year |
Citation |
Score |
| 2023 |
Lončarić M, Stojanović N, Rac-Justament A, Coopmans K, Majhen D, Humphries JD, Humphries MJ, Ambriović-Ristov A. Talin2 and KANK2 functionally interact to regulate microtubule dynamics, paclitaxel sensitivity and cell migration in the MDA-MB-435S melanoma cell line. Cellular & Molecular Biology Letters. 28: 56. PMID 37460977 DOI: 10.1186/s11658-023-00473-6 |
0.366 |
|
| 2022 |
Humphries JD, Zha J, Burns J, Askari JA, Below CR, Chastney MR, Jones MC, Mironov A, Knight D, O'Reilly DA, Dunne MJ, Garrod DR, Jorgensen C, Humphries MJ. Pancreatic ductal adenocarcinoma cells employ integrin α6β4 to form hemidesmosomes and regulate cell proliferation. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 35405272 DOI: 10.1016/j.matbio.2022.03.010 |
0.311 |
|
| 2021 |
Hamalian S, Güth R, Runa F, Sanchez F, Vickers E, Agajanian M, Molnar J, Nguyen T, Gamez J, Humphries JD, Nayak A, Humphries MJ, Tchou J, Zervantonakis IK, Kelber JA. A SNAI2-PEAK1-INHBA stromal axis drives progression and lapatinib resistance in HER2-positive breast cancer by supporting subpopulations of tumor cells positive for antiapoptotic and stress signaling markers. Oncogene. PMID 34239043 DOI: 10.1038/s41388-021-01906-2 |
0.509 |
|
| 2021 |
Gough RE, Jones MC, Zacharchenko T, Le S, Yu M, Jacquemet G, Muench SP, Yan J, Humphries JD, Jørgensen C, Humphries MJ, Goult BT. Talin mechanosensitivity is modulated by a direct interaction with cyclin-dependent kinase-1. The Journal of Biological Chemistry. 100837. PMID 34118235 DOI: 10.1016/j.jbc.2021.100837 |
0.364 |
|
| 2020 |
Chastney MR, Lawless C, Humphries MJ. Multiplexed Proximity Biotinylation Coupled to Mass Spectrometry for Defining Integrin Adhesion Complexes. Current Protocols in Cell Biology. 88: e113. PMID 32833344 DOI: 10.1002/Cpcb.113 |
0.335 |
|
| 2020 |
Samaržija I, Dekanić A, Humphries JD, Paradžik M, Stojanović N, Humphries MJ, Ambriović-Ristov A. Integrin Crosstalk Contributes to the Complexity of Signalling and Unpredictable Cancer Cell Fates. Cancers. 12. PMID 32679769 DOI: 10.3390/Cancers12071910 |
0.468 |
|
| 2020 |
Chastney MR, Lawless C, Humphries JD, Warwood S, Jones MC, Knight D, Jorgensen C, Humphries MJ. Topological features of integrin adhesion complexes revealed by multiplexed proximity biotinylation. The Journal of Cell Biology. 219. PMID 32585685 DOI: 10.1083/Jcb.202003038 |
0.371 |
|
| 2020 |
Paradžik M, Humphries JD, Stojanović N, Nestić D, Majhen D, Dekanić A, Samaržija I, Sedda D, Weber I, Humphries MJ, Ambriović-Ristov A. KANK2 Links αVβ5 Focal Adhesions to Microtubules and Regulates Sensitivity to Microtubule Poisons and Cell Migration. Frontiers in Cell and Developmental Biology. 8: 125. PMID 32195252 DOI: 10.3389/Fcell.2020.00125 |
0.451 |
|
| 2020 |
Randles MJ, Lausecker F, Humphries JD, Byron A, Clark SJ, Miner JH, Zent R, Humphries MJ, Lennon R. Basement membrane ligands initiate distinct signalling networks to direct cell shape. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 32147508 DOI: 10.1016/J.Matbio.2020.02.005 |
0.465 |
|
| 2020 |
Chen Y, Kong F, Li Z, Ju L, Park S, Garcia AJ, Mould P, Humphries MJ, Zhu C. Distinctive Mechano-sensitivity of Focal Adhesion Integrins α5β1 and αVβ3 in Conformational Changes Biophysical Journal. 118. DOI: 10.1016/J.Bpj.2019.11.999 |
0.345 |
|
| 2019 |
Jones MC, Zha J, Humphries MJ. Connections between the cell cycle, cell adhesion and the cytoskeleton. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 374: 20180227. PMID 31431178 DOI: 10.1098/Rstb.2018.0227 |
0.404 |
|
| 2019 |
Lock JG, Baschieri F, Jones MC, Humphries JD, Montagnac G, Strömblad S, Humphries MJ. Clathrin-containing adhesion complexes. The Journal of Cell Biology. PMID 31208994 DOI: 10.1083/Jcb.201811160 |
0.395 |
|
| 2018 |
Lock JG, Jones MC, Askari JA, Gong X, Oddone A, Olofsson H, Göransson S, Lakadamyali M, Humphries MJ, Strömblad S. Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis. Nature Cell Biology. 20: 1290-1302. PMID 30361699 DOI: 10.1038/S41556-018-0220-2 |
0.455 |
|
| 2018 |
Humphries JD, Chastney MR, Askari JA, Humphries MJ. Signal transduction via integrin adhesion complexes. Current Opinion in Cell Biology. 56: 14-21. PMID 30195153 DOI: 10.1016/J.Ceb.2018.08.004 |
0.451 |
|
| 2018 |
Jones MC, Askari JA, Humphries JD, Humphries MJ. Cell adhesion is regulated by CDK1 during the cell cycle. The Journal of Cell Biology. PMID 29930204 DOI: 10.1083/Jcb.201802088 |
0.403 |
|
| 2017 |
Khan MH, Salomaa SI, Jacquemet G, Butt U, Miihkinen M, Deguchi T, Kremneva E, Lappalainen P, Humphries MJ, Pouwels J. The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex. Journal of Cell Science. PMID 28775156 DOI: 10.1242/Jcs.200329 |
0.405 |
|
| 2017 |
Robertson J, Humphries JD, Paul NR, Warwood S, Knight D, Byron A, Humphries MJ. Characterization of the Phospho-Adhesome by Mass Spectrometry-Based Proteomics. Methods in Molecular Biology (Clifton, N.J.). 1636: 235-251. PMID 28730483 DOI: 10.1007/978-1-4939-7154-1_15 |
0.418 |
|
| 2017 |
Li J, Su Y, Xia W, Qin Y, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA. Conformational equilibria and intrinsic affinities define integrin activation. The Embo Journal. PMID 28122868 DOI: 10.15252/Embj.201695803 |
0.407 |
|
| 2016 |
Mana G, Clapero F, Panieri E, Panero V, Böttcher RT, Tseng HY, Saltarin F, Astanina E, Wolanska KI, Morgan MR, Humphries MJ, Santoro MM, Serini G, Valdembri D. PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis. Nature Communications. 7: 13546. PMID 27876801 DOI: 10.1038/Ncomms13546 |
0.391 |
|
| 2016 |
Horton ER, Humphries JD, James J, Jones MC, Askari JA, Humphries MJ. The integrin adhesome network at a glance. Journal of Cell Science. PMID 27799358 DOI: 10.1242/Jcs.192054 |
0.385 |
|
| 2016 |
Randles M, Humphries MJ, Lennon R. Proteomic definitions of basement membrane composition in health and disease. Matrix Biology : Journal of the International Society For Matrix Biology. PMID 27553508 DOI: 10.1016/J.Matbio.2016.08.006 |
0.315 |
|
| 2016 |
Mould AP, Askari JA, Byron A, Takada Y, Jowitt TA, Humphries MJ. Ligand-induced epitope masking. Dissociation of integrin α5β1-fibronectin complexes only by monoclonal antibodies with an allosteric mode of action. The Journal of Biological Chemistry. PMID 27484800 DOI: 10.1074/Jbc.M116.736942 |
0.416 |
|
| 2016 |
Liang X, Garcia BL, Visai L, Prabhakaran S, Meenan NA, Potts JR, Humphries MJ, Höök M. Allosteric Regulation of Fibronectin/α5β1 Interaction by Fibronectin-Binding MSCRAMMs. Plos One. 11: e0159118. PMID 27434228 DOI: 10.1371/Journal.Pone.0159118 |
0.441 |
|
| 2016 |
Su Y, Xia W, Li J, Walz T, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA. Relating conformation to function in integrin α5β1. Proceedings of the National Academy of Sciences of the United States of America. PMID 27317747 DOI: 10.1073/Pnas.1605074113 |
0.385 |
|
| 2016 |
Horton ER, Humphries JD, Stutchbury B, Jacquemet G, Ballestrem C, Barry ST, Humphries MJ. Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition. The Journal of Cell Biology. 212: 349-64. PMID 26833789 DOI: 10.1083/Jcb.201508080 |
0.36 |
|
| 2015 |
Horton ER, Astudillo P, Humphries MJ, Humphries JD. Mechanosensitivity of integrin adhesion complexes: Role of the consensus adhesome. Experimental Cell Research. PMID 26515553 DOI: 10.1016/J.Yexcr.2015.10.025 |
0.409 |
|
| 2015 |
Horton ER, Byron A, Askari JA, Ng DH, Millon-Frémillon A, Robertson J, Koper EJ, Paul NR, Warwood S, Knight D, Humphries JD, Humphries MJ. Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly. Nature Cell Biology. PMID 26479319 DOI: 10.1038/Ncb3257 |
0.415 |
|
| 2015 |
Ajeian JN, Horton ER, Astudillo P, Byron A, Askari JA, Millon-Frémillon A, Knight D, Kimber SJ, Humphries MJ, Humphries JD. Proteomic analysis of integrin-associated complexes from mesenchymal stem cells. Proteomics. Clinical Applications. PMID 26147903 DOI: 10.1002/Prca.201500033 |
0.365 |
|
| 2015 |
Randles MJ, Woolf AS, Huang JL, Byron A, Humphries JD, Price KL, Kolatsi-Joannou M, Collinson S, Denny T, Knight D, Mironov A, Starborg T, Korstanje R, Humphries MJ, Long DA, et al. Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization. Journal of the American Society of Nephrology : Jasn. PMID 25896609 DOI: 10.1681/Asn.2014040419 |
0.338 |
|
| 2015 |
Humphries JD, Paul NR, Humphries MJ, Morgan MR. Emerging properties of adhesion complexes: what are they and what do they do? Trends in Cell Biology. 25: 388-97. PMID 25824971 DOI: 10.1016/J.Tcb.2015.02.008 |
0.372 |
|
| 2015 |
Jones MC, Humphries JD, Byron A, Millon-Frémillon A, Robertson J, Paul NR, Ng DH, Askari JA, Humphries MJ. Isolation of integrin-based adhesion complexes. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. 66: 9.8.1-9.8.15. PMID 25727331 DOI: 10.1002/0471143030.Cb0908S66 |
0.453 |
|
| 2015 |
Robertson J, Jacquemet G, Byron A, Jones MC, Warwood S, Selley JN, Knight D, Humphries JD, Humphries MJ. Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling. Nature Communications. 6: 6265. PMID 25677187 DOI: 10.1038/Ncomms7265 |
0.414 |
|
| 2015 |
Byron A, Askari JA, Humphries JD, Jacquemet G, Koper EJ, Warwood S, Choi CK, Stroud MJ, Chen CS, Knight D, Humphries MJ. A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting. Nature Communications. 6: 6135. PMID 25609142 DOI: 10.1038/Ncomms7135 |
0.42 |
|
| 2014 |
Ng DH, Humphries JD, Byron A, Millon-Frémillon A, Humphries MJ. Microtubule-dependent modulation of adhesion complex composition. Plos One. 9: e115213. PMID 25526367 DOI: 10.1371/Journal.Pone.0115213 |
0.42 |
|
| 2014 |
Lennon R, Randles MJ, Humphries MJ. The importance of podocyte adhesion for a healthy glomerulus. Frontiers in Endocrinology. 5: 160. PMID 25352829 DOI: 10.3389/Fendo.2014.00160 |
0.442 |
|
| 2014 |
Mould AP, Craig SE, Byron SK, Humphries MJ, Jowitt TA. Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors. The Biochemical Journal. 464: 301-13. PMID 25333419 DOI: 10.1042/Bj20141047 |
0.394 |
|
| 2014 |
Pritchett J, Athwal VS, Harvey E, Martin K, Llewellyn J, Ireland P, Nicolaides A, Humphries MJ, Bobola N, Hanley NA, Piper Hanley K. Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells. Plos One. 9: e100091. PMID 24971829 DOI: 10.1371/Journal.Pone.0100091 |
0.348 |
|
| 2014 |
Byron A, Randles MJ, Humphries JD, Mironov A, Hamidi H, Harris S, Mathieson PW, Saleem MA, Satchell SC, Zent R, Humphries MJ, Lennon R. Glomerular cell cross-talk influences composition and assembly of extracellular matrix. Journal of the American Society of Nephrology : Jasn. 25: 953-66. PMID 24436469 DOI: 10.1681/Asn.2013070795 |
0.395 |
|
| 2014 |
Lennon R, Byron A, Humphries JD, Randles MJ, Carisey A, Murphy S, Knight D, Brenchley PE, Zent R, Humphries MJ. Global analysis reveals the complexity of the human glomerular extracellular matrix. Journal of the American Society of Nephrology : Jasn. 25: 939-51. PMID 24436468 DOI: 10.1681/Asn.2013030233 |
0.327 |
|
| 2013 |
Ernst N, Yay A, BÃró T, Tiede S, Humphries M, Paus R, Kloepper JE. β1 integrin signaling maintains human epithelial progenitor cell survival in situ and controls proliferation, apoptosis and migration of their progeny. Plos One. 8: e84356. PMID 24386370 DOI: 10.1371/Journal.Pone.0084356 |
0.391 |
|
| 2013 |
Jacquemet G, Humphries MJ. IQGAP1 is a key node within the small GTPase network. Small Gtpases. 4: 199-207. PMID 24355937 DOI: 10.4161/Sgtp.27451 |
0.356 |
|
| 2013 |
Seong J, Tajik A, Sun J, Guan JL, Humphries MJ, Craig SE, Shekaran A, GarcÃa AJ, Lu S, Lin MZ, Wang N, Wang Y. Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins. Proceedings of the National Academy of Sciences of the United States of America. 110: 19372-7. PMID 24222685 DOI: 10.1073/Pnas.1307405110 |
0.478 |
|
| 2013 |
Jacquemet G, Green DM, Bridgewater RE, von Kriegsheim A, Humphries MJ, Norman JC, Caswell PT. RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex. The Journal of Cell Biology. 202: 917-35. PMID 24019536 DOI: 10.1083/Jcb.201302041 |
0.379 |
|
| 2013 |
Jacquemet G, Morgan MR, Byron A, Humphries JD, Choi CK, Chen CS, Caswell PT, Humphries MJ. Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway. Journal of Cell Science. 126: 4121-35. PMID 23843620 DOI: 10.1242/Jcs.121988 |
0.444 |
|
| 2013 |
Jacquemet G, Humphries MJ, Caswell PT. Role of adhesion receptor trafficking in 3D cell migration. Current Opinion in Cell Biology. 25: 627-32. PMID 23797030 DOI: 10.1016/J.Ceb.2013.05.008 |
0.414 |
|
| 2013 |
Soteriou D, Iskender B, Byron A, Humphries JD, Borg-Bartolo S, Haddock MC, Baxter MA, Knight D, Humphries MJ, Kimber SJ. Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance. The Journal of Biological Chemistry. 288: 18716-31. PMID 23658023 DOI: 10.1074/Jbc.M113.463372 |
0.338 |
|
| 2013 |
Morgan MR, Hamidi H, Bass MD, Warwood S, Ballestrem C, Humphries MJ. Syndecan-4 phosphorylation is a control point for integrin recycling. Developmental Cell. 24: 472-85. PMID 23453597 DOI: 10.1016/J.Devcel.2013.01.027 |
0.363 |
|
| 2013 |
Byron A, Humphries JD, Humphries MJ. Defining the extracellular matrix using proteomics. International Journal of Experimental Pathology. 94: 75-92. PMID 23419153 DOI: 10.1111/Iep.12011 |
0.421 |
|
| 2013 |
Kong F, Li Z, Parks WM, Dumbauld DW, GarcÃa AJ, Mould AP, Humphries MJ, Zhu C. Cyclic mechanical reinforcement of integrin-ligand interactions. Molecular Cell. 49: 1060-8. PMID 23416109 DOI: 10.1016/J.Molcel.2013.01.015 |
0.416 |
|
| 2013 |
Lin GL, Cohen DM, Desai RA, Breckenridge MT, Gao L, Humphries MJ, Chen CS. Activation of beta 1 but not beta 3 integrin increases cell traction forces. Febs Letters. 587: 763-9. PMID 23395612 DOI: 10.1016/J.Febslet.2013.01.068 |
0.411 |
|
| 2013 |
Kong F, Li Z, Parks WM, Dumbauld DW, García AJ, Mould AP, Humphries MJ, Zhu C. Errata to Cyclic mechanical reinforcement of integrin-ligand interactions [Molecular Cell 49, (2013) 1060-1068] Molecular Cell. 49: 1176. DOI: 10.1016/J.Molcel.2013.03.008 |
0.401 |
|
| 2012 |
Rashid ST, Humphries JD, Byron A, Dhar A, Askari JA, Selley JN, Knight D, Goldin RD, Thursz M, Humphries MJ. Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver. Journal of Proteome Research. 11: 4052-64. PMID 22694338 DOI: 10.1021/Pr3000927 |
0.329 |
|
| 2012 |
Le Goff MM, Sutton MJ, Slevin M, Latif A, Humphries MJ, Bishop PN. Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness. The Journal of Biological Chemistry. 287: 28027-36. PMID 22669977 DOI: 10.1074/Jbc.M111.331157 |
0.407 |
|
| 2012 |
Byron A, Humphries JD, Craig SE, Knight D, Humphries MJ. Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment. Proteomics. 12: 2107-14. PMID 22623428 DOI: 10.1002/Pmic.201100487 |
0.501 |
|
| 2012 |
Byron A, Humphries JD, Humphries MJ. Alternative cellular roles for proteins identified using proteomics. Journal of Proteomics. 75: 4184-5. PMID 22579753 DOI: 10.1016/J.Jprot.2012.04.049 |
0.411 |
|
| 2011 |
Bass MD, Williamson RC, Nunan RD, Humphries JD, Byron A, Morgan MR, Martin P, Humphries MJ. A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis. Developmental Cell. 21: 681-93. PMID 21982645 DOI: 10.1016/J.Devcel.2011.08.007 |
0.451 |
|
| 2011 |
Rantala JK, Pouwels J, Pellinen T, Veltel S, Laasola P, Mattila E, Potter CS, Duffy T, Sundberg JP, Kallioniemi O, Askari JA, Humphries MJ, Parsons M, Salmi M, Ivaska J. SHARPIN is an endogenous inhibitor of β1-integrin activation. Nature Cell Biology. 13: 1315-24. PMID 21947080 DOI: 10.1038/Ncb2340 |
0.372 |
|
| 2011 |
Tiwari S, Askari JA, Humphries MJ, Bulleid NJ. Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking. Journal of Cell Science. 124: 1672-80. PMID 21511727 DOI: 10.1242/Jcs.084483 |
0.473 |
|
| 2011 |
Byron A, Humphries JD, Bass MD, Knight D, Humphries MJ. Proteomic analysis of integrin adhesion complexes. Science Signaling. 4: pt2. PMID 21467297 DOI: 10.1126/Scisignal.2001827 |
0.434 |
|
| 2011 |
Campbell ID, Humphries MJ. Integrin structure, activation, and interactions. Cold Spring Harbor Perspectives in Biology. 3. PMID 21421922 DOI: 10.1101/Cshperspect.A004994 |
0.464 |
|
| 2010 |
Siebert HC, Burg-Roderfeld M, Eckert T, Stötzel S, Kirch U, Diercks T, Humphries MJ, Frank M, Wechselberger R, Tajkhorshid E, Oesser S. Interaction of the α2A domain of integrin with small collagen fragments. Protein & Cell. 1: 393-405. PMID 21203951 DOI: 10.1007/S13238-010-0038-6 |
0.396 |
|
| 2010 |
Byron A, Morgan MR, Humphries MJ. Adhesion signalling complexes. Current Biology : Cb. 20: R1063-7. PMID 21172621 DOI: 10.1016/J.Cub.2010.10.059 |
0.42 |
|
| 2010 |
Worth DC, Hodivala-Dilke K, Robinson SD, King SJ, Morton PE, Gertler FB, Humphries MJ, Parsons M. Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. The Journal of Cell Biology. 189: 369-83. PMID 20404115 DOI: 10.1083/Jcb.200912014 |
0.472 |
|
| 2010 |
Askari JA, Tynan CJ, Webb SE, Martin-Fernandez ML, Ballestrem C, Humphries MJ. Focal adhesions are sites of integrin extension. The Journal of Cell Biology. 188: 891-903. PMID 20231384 DOI: 10.1083/Jcb.200907174 |
0.484 |
|
| 2009 |
Byron A, Humphries JD, Askari JA, Craig SE, Mould AP, Humphries MJ. Anti-integrin monoclonal antibodies. Journal of Cell Science. 122: 4009-11. PMID 19910492 DOI: 10.1242/Jcs.056770 |
0.436 |
|
| 2009 |
Humphries MJ, Reynolds A. Cell-to-cell contact and extracellular matrix. Current Opinion in Cell Biology. 21: 613-5. PMID 19773151 DOI: 10.1016/J.Ceb.2009.09.001 |
0.372 |
|
| 2009 |
Mould AP, Koper EJ, Byron A, Zahn G, Humphries MJ. Mapping the ligand-binding pocket of integrin alpha5beta1 using a gain-of-function approach. The Biochemical Journal. 424: 179-89. PMID 19747169 DOI: 10.1042/Bj20090992 |
0.474 |
|
| 2009 |
Humphries JD, Byron A, Bass MD, Craig SE, Pinney JW, Knight D, Humphries MJ. Proteomic analysis of integrin-associated complexes identifies RCC2 as a dual regulator of Rac1 and Arf6. Science Signaling. 2: ra51. PMID 19738201 DOI: 10.1126/Scisignal.2000396 |
0.509 |
|
| 2009 |
Kong F, GarcÃa AJ, Mould AP, Humphries MJ, Zhu C. Demonstration of catch bonds between an integrin and its ligand. The Journal of Cell Biology. 185: 1275-84. PMID 19564406 DOI: 10.1083/Jcb.200810002 |
0.4 |
|
| 2009 |
Morgan MR, Byron A, Humphries MJ, Bass MD. Giving off mixed signals--distinct functions of alpha5beta1 and alphavbeta3 integrins in regulating cell behaviour. Iubmb Life. 61: 731-8. PMID 19514020 DOI: 10.1002/Iub.200 |
0.504 |
|
| 2009 |
Faye C, Moreau C, Chautard E, Jetne R, Fukai N, Ruggiero F, Humphries MJ, Olsen BR, Ricard-Blum S. Molecular interplay between endostatin, integrins, and heparan sulfate. The Journal of Biological Chemistry. 284: 22029-40. PMID 19502598 DOI: 10.1074/Jbc.M109.002840 |
0.475 |
|
| 2009 |
Deakin NO, Bass MD, Warwood S, Schoelermann J, Mostafavi-Pour Z, Knight D, Ballestrem C, Humphries MJ. An integrin-alpha4-14-3-3zeta-paxillin ternary complex mediates localised Cdc42 activity and accelerates cell migration. Journal of Cell Science. 122: 1654-64. PMID 19401330 DOI: 10.1242/Jcs.049130 |
0.446 |
|
| 2009 |
Bass MD, Morgan MR, Humphries MJ. Syndecans shed their reputation as inert molecules. Science Signaling. 2: pe18. PMID 19336838 DOI: 10.1126/Scisignal.264Pe18 |
0.411 |
|
| 2009 |
Humphries MJ. Cell adhesion assays. Methods in Molecular Biology (Clifton, N.J.). 522: 203-10. PMID 19247616 DOI: 10.1007/978-1-59745-413-1_14 |
0.445 |
|
| 2009 |
Valdembri D, Caswell PT, Anderson KI, Schwarz JP, König I, Astanina E, Caccavari F, Norman JC, Humphries MJ, Bussolino F, Serini G. Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. Plos Biology. 7: e25. PMID 19175293 DOI: 10.1371/Journal.Pbio.1000025 |
0.329 |
|
| 2009 |
Mahoney CM, Morgan MR, Harrison A, Humphries MJ, Bass MD. Therapeutic ultrasound bypasses canonical syndecan-4 signaling to activate rac1. The Journal of Biological Chemistry. 284: 8898-909. PMID 19147498 DOI: 10.1074/Jbc.M804281200 |
0.406 |
|
| 2009 |
Askari JA, Buckley PA, Mould AP, Humphries MJ. Linking integrin conformation to function. Journal of Cell Science. 122: 165-70. PMID 19118208 DOI: 10.1242/Jcs.018556 |
0.414 |
|
| 2008 |
Valdramidou D, Humphries MJ, Mould AP. Distinct roles of beta1 metal ion-dependent adhesion site (MIDAS), adjacent to MIDAS (ADMIDAS), and ligand-associated metal-binding site (LIMBS) cation-binding sites in ligand recognition by integrin alpha2beta1. The Journal of Biological Chemistry. 283: 32704-14. PMID 18820259 DOI: 10.1074/Jbc.M802066200 |
0.431 |
|
| 2008 |
Bass MD, Morgan MR, Roach KA, Settleman J, Goryachev AB, Humphries MJ. p190RhoGAP is the convergence point of adhesion signals from alpha 5 beta 1 integrin and syndecan-4. The Journal of Cell Biology. 181: 1013-26. PMID 18541700 DOI: 10.1083/Jcb.200711129 |
0.482 |
|
| 2008 |
Telci D, Wang Z, Li X, Verderio EA, Humphries MJ, Baccarini M, Basaga H, Griffin M. Fibronectin-tissue transglutaminase matrix rescues RGD-impaired cell adhesion through syndecan-4 and beta1 integrin co-signaling. The Journal of Biological Chemistry. 283: 20937-47. PMID 18499669 DOI: 10.1074/Jbc.M801763200 |
0.498 |
|
| 2008 |
Parsons M, Messent AJ, Humphries JD, Deakin NO, Humphries MJ. Quantification of integrin receptor agonism by fluorescence lifetime imaging. Journal of Cell Science. 121: 265-71. PMID 18216331 DOI: 10.1242/Jcs.018440 |
0.416 |
|
| 2008 |
Kloepper JE, Hendrix S, Bodó E, Tiede S, Humphries MJ, Philpott MP, Fässler R, Paus R. Functional role of beta 1 integrin-mediated signalling in the human hair follicle. Experimental Cell Research. 314: 498-508. PMID 18155697 DOI: 10.1016/J.Yexcr.2007.10.030 |
0.343 |
|
| 2007 |
Bass MD, Morgan MR, Humphries MJ. Integrins and syndecan-4 make distinct, but critical, contributions to adhesion contact formation. Soft Matter. 3: 372-376. PMID 19458789 DOI: 10.1039/B614610D |
0.463 |
|
| 2007 |
Humphries JD, Wang P, Streuli C, Geiger B, Humphries MJ, Ballestrem C. Vinculin controls focal adhesion formation by direct interactions with talin and actin. The Journal of Cell Biology. 179: 1043-57. PMID 18056416 DOI: 10.1083/Jcb.200703036 |
0.436 |
|
| 2007 |
Morgan MR, Humphries MJ, Bass MD. Synergistic control of cell adhesion by integrins and syndecans. Nature Reviews. Molecular Cell Biology. 8: 957-69. PMID 17971838 DOI: 10.1038/Nrm2289 |
0.448 |
|
| 2007 |
Caswell PT, Spence HJ, Parsons M, White DP, Clark K, Cheng KW, Mills GB, Humphries MJ, Messent AJ, Anderson KI, McCaffrey MW, Ozanne BW, Norman JC. Rab25 associates with alpha5beta1 integrin to promote invasive migration in 3D microenvironments. Developmental Cell. 13: 496-510. PMID 17925226 DOI: 10.1016/J.Devcel.2007.08.012 |
0.392 |
|
| 2007 |
Askari JA, Thornton DJ, Humphries JD, Buckley PA, Humphries MJ. The alternatively spliced type III connecting segment of fibronectin is a zinc-binding module. Matrix Biology : Journal of the International Society For Matrix Biology. 26: 485-93. PMID 17490871 DOI: 10.1016/J.Matbio.2007.04.001 |
0.37 |
|
| 2007 |
Bass MD, Roach KA, Morgan MR, Mostafavi-Pour Z, Schoen T, Muramatsu T, Mayer U, Ballestrem C, Spatz JP, Humphries MJ. Syndecan-4-dependent Rac1 regulation determines directional migration in response to the extracellular matrix. The Journal of Cell Biology. 177: 527-38. PMID 17485492 DOI: 10.1083/Jcb.200610076 |
0.422 |
|
| 2007 |
Bax DV, Mahalingam Y, Cain S, Mellody K, Freeman L, Younger K, Shuttleworth CA, Humphries MJ, Couchman JR, Kielty CM. Cell adhesion to fibrillin-1: identification of an Arg-Gly-Asp-dependent synergy region and a heparin-binding site that regulates focal adhesion formation. Journal of Cell Science. 120: 1383-92. PMID 17374638 DOI: 10.1242/Jcs.003954 |
0.482 |
|
| 2007 |
Humphries JD, Humphries MJ. CD14 is a ligand for the integrin alpha4beta1. Febs Letters. 581: 757-63. PMID 17274987 DOI: 10.1016/J.Febslet.2007.01.038 |
0.411 |
|
| 2007 |
Watson PM, Humphries MJ, Relton J, Rothwell NJ, Verkhratsky A, Gibson RM. Integrin-binding RGD peptides induce rapid intracellular calcium increases and MAPK signaling in cortical neurons. Molecular and Cellular Neurosciences. 34: 147-54. PMID 17150373 DOI: 10.1016/J.Mcn.2006.10.007 |
0.375 |
|
| 2006 |
Wijelath ES, Rahman S, Namekata M, Murray J, Nishimura T, Mostafavi-Pour Z, Patel Y, Suda Y, Humphries MJ, Sobel M. Heparin-II domain of fibronectin is a vascular endothelial growth factor-binding domain: enhancement of VEGF biological activity by a singular growth factor/matrix protein synergism. Circulation Research. 99: 853-60. PMID 17008606 DOI: 10.1161/01.Res.0000246849.17887.66 |
0.388 |
|
| 2006 |
Humphries JD, Byron A, Humphries MJ. Integrin ligands at a glance. Journal of Cell Science. 119: 3901-3. PMID 16988024 DOI: 10.1242/Jcs.03098 |
0.431 |
|
| 2006 |
Sumathipala R, Xu C, Seago J, Mould AP, Humphries MJ, Craig SE, Patel Y, Wijelath ES, Sobel M, Rahman S. The "linker" region (amino acids 38-47) of the disintegrin elegantin is a novel inhibitory domain of integrin alpha5beta1-dependent cell adhesion on fibronectin: evidence for the negative regulation of fibronectin synergy site biological activity. The Journal of Biological Chemistry. 281: 37686-96. PMID 16982624 DOI: 10.1074/Jbc.M603943200 |
0.485 |
|
| 2006 |
Turner NJ, Murphy MO, Kielty CM, Shuttleworth CA, Black RA, Humphries MJ, Walker MG, Canfield AE. Alpha2(VIII) collagen substrata enhance endothelial cell retention under acute shear stress flow via an alpha2beta1 integrin-dependent mechanism: an in vitro and in vivo study. Circulation. 114: 820-9. PMID 16908762 DOI: 10.1161/Circulationaha.106.635292 |
0.376 |
|
| 2006 |
Mould AP, McLeish JA, Huxley-Jones J, Goonesinghe AC, Hurlstone AF, Boot-Handford RP, Humphries MJ. Identification of multiple integrin beta1 homologs in zebrafish (Danio rerio). Bmc Cell Biology. 7: 24. PMID 16787535 DOI: 10.1186/1471-2121-7-24 |
0.351 |
|
| 2006 |
Bauer R, Humphries M, Fässler R, Winklmeier A, Craig SE, Bosserhoff AK. Regulation of integrin activity by MIA. The Journal of Biological Chemistry. 281: 11669-77. PMID 16517605 DOI: 10.1074/Jbc.M511367200 |
0.413 |
|
| 2005 |
Humphries MJ, Mostafavi-Pour Z, Morgan MR, Deakin NO, Messent AJ, Bass MD. Integrin-syndecan cooperation governs the assembly of signalling complexes during cell spreading. Novartis Foundation Symposium. 269: 178-88; discussion 1. PMID 16355540 DOI: 10.1002/047001766X.Ch14 |
0.488 |
|
| 2005 |
Gläsner J, Blum H, Wehner V, Stilz HU, Humphries JD, Curley GP, Mould AP, Humphries MJ, Hallmann R, Röllinghoff M, Gessner A. A small molecule alpha 4 beta 1 antagonist prevents development of murine Lyme arthritis without affecting protective immunity. Journal of Immunology (Baltimore, Md. : 1950). 175: 4724-34. PMID 16177120 DOI: 10.4049/Jimmunol.175.7.4724 |
0.348 |
|
| 2005 |
Meng X, Cheng K, Krohkin O, Mould AP, Humphries MJ, Ens W, Standing K, Wilkins JA. Evidence for the presence of a low-mass beta1 integrin on the cell surface. Journal of Cell Science. 118: 4009-16. PMID 16105875 DOI: 10.1242/Jcs.02520 |
0.393 |
|
| 2005 |
Ewan R, Huxley-Jones J, Mould AP, Humphries MJ, Robertson DL, Boot-Handford RP. The integrins of the urochordate Ciona intestinalis provide novel insights into the molecular evolution of the vertebrate integrin family. Bmc Evolutionary Biology. 5: 31. PMID 15892888 DOI: 10.1186/1471-2148-5-31 |
0.406 |
|
| 2005 |
Gibson RM, Craig SE, Heenan L, Tournier C, Humphries MJ. Activation of integrin alpha5beta1 delays apoptosis of Ntera2 neuronal cells. Molecular and Cellular Neurosciences. 28: 588-98. PMID 15737747 DOI: 10.1016/J.Mcn.2004.11.004 |
0.432 |
|
| 2005 |
Bella J, Humphries MJ. Calpha-H...O = C hydrogen bonds contribute to the specificity of RGD cell-adhesion interactions. Bmc Structural Biology. 5: 4. PMID 15710040 DOI: 10.1186/1472-6807-5-4 |
0.399 |
|
| 2005 |
Wei Y, Czekay RP, Robillard L, Kugler MC, Zhang F, Kim KK, Xiong JP, Humphries MJ, Chapman HA. Regulation of alpha5beta1 integrin conformation and function by urokinase receptor binding. The Journal of Cell Biology. 168: 501-11. PMID 15684035 DOI: 10.1083/Jcb.200404112 |
0.425 |
|
| 2005 |
Dallas SL, Sivakumar P, Jones CJ, Chen Q, Peters DM, Mosher DF, Humphries MJ, Kielty CM. Fibronectin regulates latent transforming growth factor-beta (TGF beta) by controlling matrix assembly of latent TGF beta-binding protein-1. The Journal of Biological Chemistry. 280: 18871-80. PMID 15677465 DOI: 10.1074/Jbc.M410762200 |
0.4 |
|
| 2005 |
Humphries JD, Schofield NR, Mostafavi-Pour Z, Green LJ, Garratt AN, Mould AP, Humphries MJ. Dual functionality of the anti-beta1 integrin antibody, 12G10, exemplifies agonistic signalling from the ligand binding pocket of integrin adhesion receptors. The Journal of Biological Chemistry. 280: 10234-43. PMID 15632175 DOI: 10.1074/Jbc.M411102200 |
0.765 |
|
| 2005 |
Clark K, Pankov R, Travis MA, Askari JA, Mould AP, Craig SE, Newham P, Yamada KM, Humphries MJ. A specific alpha5beta1-integrin conformation promotes directional integrin translocation and fibronectin matrix formation. Journal of Cell Science. 118: 291-300. PMID 15615773 DOI: 10.1242/Jcs.01623 |
0.487 |
|
| 2005 |
Mould AP, Travis MA, Barton SJ, Hamilton JA, Askari JA, Craig SE, Macdonald PR, Kammerer RA, Buckley PA, Humphries MJ. Evidence that monoclonal antibodies directed against the integrin beta subunit plexin/semaphorin/integrin domain stimulate function by inducing receptor extension. The Journal of Biological Chemistry. 280: 4238-46. PMID 15557320 DOI: 10.1074/Jbc.M412240200 |
0.453 |
|
| 2004 |
Mould AP, Humphries MJ. Cell biology: adhesion articulated. Nature. 432: 27-8. PMID 15525967 DOI: 10.1038/432027A |
0.396 |
|
| 2004 |
Humphries MJ, Travis MA, Clark K, Mould AP. Mechanisms of integration of cells and extracellular matrices by integrins. Biochemical Society Transactions. 32: 822-5. PMID 15494024 DOI: 10.1042/Bst0320822 |
0.433 |
|
| 2004 |
Mould AP, Humphries MJ. Regulation of integrin function through conformational complexity: not simply a knee-jerk reaction? Current Opinion in Cell Biology. 16: 544-51. PMID 15363805 DOI: 10.1016/J.Ceb.2004.07.003 |
0.435 |
|
| 2004 |
Zhang X, Craig SE, Kirby H, Humphries MJ, Moy VT. Molecular basis for the dynamic strength of the integrin alpha4beta1/VCAM-1 interaction. Biophysical Journal. 87: 3470-8. PMID 15347595 DOI: 10.1529/Biophysj.104.045690 |
0.392 |
|
| 2004 |
Travis MA, van der Flier A, Kammerer RA, Mould AP, Sonnenberg A, Humphries MJ. Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation. Febs Letters. 569: 185-90. PMID 15225631 DOI: 10.1016/J.Febslet.2004.04.099 |
0.431 |
|
| 2004 |
Humphries MJ. Monoclonal antibodies as probes of integrin priming and activation. Biochemical Society Transactions. 32: 407-11. PMID 15157148 DOI: 10.1042/Bst0320407 |
0.467 |
|
| 2004 |
Bax DV, Messent AJ, Tart J, van Hoang M, Kott J, Maciewicz RA, Humphries MJ. Integrin alpha5beta1 and ADAM-17 interact in vitro and co-localize in migrating HeLa cells. The Journal of Biological Chemistry. 279: 22377-86. PMID 14970227 DOI: 10.1074/Jbc.M400180200 |
0.496 |
|
| 2004 |
Barton SJ, Travis MA, Askari JA, Buckley PA, Craig SE, Humphries MJ, Mould AP. Novel activating and inactivating mutations in the integrin beta1 subunit A domain. The Biochemical Journal. 380: 401-7. PMID 14967067 DOI: 10.1042/Bj20031973 |
0.434 |
|
| 2003 |
Mould AP, Barton SJ, Askari JA, Craig SE, Humphries MJ. Role of ADMIDAS cation-binding site in ligand recognition by integrin alpha 5 beta 1. The Journal of Biological Chemistry. 278: 51622-9. PMID 14532288 DOI: 10.1074/Jbc.M306655200 |
0.473 |
|
| 2003 |
Mould AP, Symonds EJ, Buckley PA, Grossmann JG, McEwan PA, Barton SJ, Askari JA, Craig SE, Bella J, Humphries MJ. Structure of an integrin-ligand complex deduced from solution x-ray scattering and site-directed mutagenesis. The Journal of Biological Chemistry. 278: 39993-9. PMID 12871973 DOI: 10.1074/Jbc.M304627200 |
0.43 |
|
| 2003 |
Humphries MJ, McEwan PA, Barton SJ, Buckley PA, Bella J, Mould AP. Integrin structure: heady advances in ligand binding, but activation still makes the knees wobble. Trends in Biochemical Sciences. 28: 313-20. PMID 12826403 DOI: 10.1016/S0968-0004(03)00112-9 |
0.439 |
|
| 2003 |
Bax DV, Bernard SE, Lomas A, Morgan A, Humphries J, Shuttleworth CA, Humphries MJ, Kielty CM. Cell adhesion to fibrillin-1 molecules and microfibrils is mediated by alpha 5 beta 1 and alpha v beta 3 integrins. The Journal of Biological Chemistry. 278: 34605-16. PMID 12807887 DOI: 10.1074/Jbc.M303159200 |
0.527 |
|
| 2003 |
Humphries MJ, Symonds EJ, Mould AP. Mapping functional residues onto integrin crystal structures. Current Opinion in Structural Biology. 13: 236-43. PMID 12727518 DOI: 10.1016/S0959-440X(03)00035-6 |
0.374 |
|
| 2003 |
Travis MA, Humphries JD, Humphries MJ. An unraveling tale of how integrins are activated from within. Trends in Pharmacological Sciences. 24: 192-7. PMID 12707006 DOI: 10.1016/S0165-6147(03)00069-5 |
0.417 |
|
| 2003 |
Mostafavi-Pour Z, Askari JA, Parkinson SJ, Parker PJ, Ng TT, Humphries MJ. Integrin-specific signaling pathways controlling focal adhesion formation and cell migration. The Journal of Cell Biology. 161: 155-67. PMID 12695503 DOI: 10.1083/Jcb.200210176 |
0.504 |
|
| 2003 |
Mould AP, Barton SJ, Askari JA, McEwan PA, Buckley PA, Craig SE, Humphries MJ. Conformational changes in the integrin beta A domain provide a mechanism for signal transduction via hybrid domain movement. The Journal of Biological Chemistry. 278: 17028-35. PMID 12615914 DOI: 10.1074/Jbc.M213139200 |
0.46 |
|
| 2002 |
Whittard JD, Craig SE, Mould AP, Koch A, Pertz O, Engel J, Humphries MJ. E-cadherin is a ligand for integrin alpha2beta1. Matrix Biology : Journal of the International Society For Matrix Biology. 21: 525-32. PMID 12392763 DOI: 10.1016/S0945-053X(02)00037-9 |
0.444 |
|
| 2002 |
Bass MD, Humphries MJ. Cytoplasmic interactions of syndecan-4 orchestrate adhesion receptor and growth factor receptor signalling. The Biochemical Journal. 368: 1-15. PMID 12241528 DOI: 10.1042/Bj20021228 |
0.491 |
|
| 2002 |
Parsons M, Keppler MD, Kline A, Messent A, Humphries MJ, Gilchrist R, Hart IR, Quittau-Prevostel C, Hughes WE, Parker PJ, Ng T. Site-directed perturbation of protein kinase C- integrin interaction blocks carcinoma cell chemotaxis. Molecular and Cellular Biology. 22: 5897-911. PMID 12138200 DOI: 10.1128/Mcb.22.16.5897-5911.2002 |
0.456 |
|
| 2002 |
Humphries MJ. Insights into integrin-ligand binding and activation from the first crystal structure. Arthritis Research. 4: S69-78. PMID 12110125 DOI: 10.1186/Ar563 |
0.397 |
|
| 2002 |
Mould AP, Askari JA, Barton S, Kline AD, McEwan PA, Craig SE, Humphries MJ. Integrin activation involves a conformational change in the alpha 1 helix of the beta subunit A-domain. The Journal of Biological Chemistry. 277: 19800-5. PMID 11893752 DOI: 10.1074/Jbc.M201571200 |
0.459 |
|
| 2002 |
Aquilina A, Korda M, Bergelson JM, Humphries MJ, Farndale RW, Tuckwell D. A novel gain-of-function mutation of the integrin alpha2 VWFA domain. European Journal of Biochemistry / Febs. 269: 1136-44. PMID 11856343 DOI: 10.1046/J.0014-2956.2001.02740.X |
0.449 |
|
| 2002 |
Santas AJ, Peterson JA, Halbleib JL, Craig SE, Humphries MJ, Peters DM. Alternative splicing of the IIICS domain in fibronectin governs the role of the heparin II domain in fibrillogenesis and cell spreading. The Journal of Biological Chemistry. 277: 13650-8. PMID 11832485 DOI: 10.1074/Jbc.M111361200 |
0.33 |
|
| 2001 |
Humphries MJ. Cell-substrate adhesion assays. Current Protocols in Cell Biology / Editorial Board, Juan S. Bonifacino ... [Et Al.]. Unit 9.1. PMID 18228391 DOI: 10.1002/0471143030.Cb0901S00 |
0.361 |
|
| 2001 |
Humphries MJ, Mould AP. Structure. An anthropomorphic integrin. Science (New York, N.Y.). 294: 316-7. PMID 11598288 DOI: 10.1126/Science.1066240 |
0.343 |
|
| 2001 |
Hicks MS, O'Leary V, Wilkin M, Bee SE, Humphries MJ, Baron M. DrhoGEF3 encodes a new Drosophila DH domain protein that exhibits a highly dynamic embryonic expression pattern. Development Genes and Evolution. 211: 263-7. PMID 11455443 DOI: 10.1007/S004270100146 |
0.34 |
|
| 2001 |
Humphries MJ. Cell adhesion assays. Molecular Biotechnology. 18: 57-61. PMID 11439699 DOI: 10.1385/Mb:18:1:57 |
0.403 |
|
| 2001 |
Coe AP, Askari JA, Kline AD, Robinson MK, Kirby H, Stephens PE, Humphries MJ. Generation of a minimal alpha5beta1 integrin-Fc fragment. The Journal of Biological Chemistry. 276: 35854-66. PMID 11389148 DOI: 10.1074/Jbc.M103639200 |
0.478 |
|
| 2001 |
Stallmach A, Giese T, Pfister K, Wittig BM, Künne S, Humphries M, Zeitz M, Meuer SC. Activation of beta(1) integrins mediates proliferation and inhibits apoptosis of intestinal CD4-positive lymphocytes. European Journal of Immunology. 31: 1228-38. PMID 11298349 DOI: 10.1002/1521-4141(200104)31:4<1228::Aid-Immu1228>3.0.Co;2-K |
0.304 |
|
| 2001 |
Mostafavi-Pour Z, Askari JA, Whittard JD, Humphries MJ. Identification of a novel heparin-binding site in the alternatively spliced IIICS region of fibronectin: roles of integrins and proteoglycans in cell adhesion to fibronectin splice variants. Matrix Biology : Journal of the International Society For Matrix Biology. 20: 63-73. PMID 11246004 DOI: 10.1016/S0945-053X(00)00131-1 |
0.471 |
|
| 2000 |
Tuckwell DS, Smith L, Korda M, Askari JA, Santoso S, Barnes MJ, Farndale RW, Humphries MJ. Monoclonal antibodies identify residues 199-216 of the integrin alpha2 vWFA domain as a functionally important region within alpha2beta1. The Biochemical Journal. 350: 485-93. PMID 10947963 DOI: 10.1042/0264-6021:3500485 |
0.437 |
|
| 2000 |
Jackson T, Blakemore W, Newman JW, Knowles NJ, Mould AP, Humphries MJ, King AM. Foot-and-mouth disease virus is a ligand for the high-affinity binding conformation of integrin alpha5beta1: influence of the leucine residue within the RGDL motif on selectivity of integrin binding. The Journal of General Virology. 81: 1383-91. PMID 10769082 DOI: 10.1099/0022-1317-81-5-1383 |
0.316 |
|
| 2000 |
Clark K, Newham P, Burrows L, Askari JA, Humphries MJ. Production of recombinant soluble human integrin alpha4beta1. Febs Letters. 471: 182-6. PMID 10767419 DOI: 10.1016/S0014-5793(00)01391-0 |
0.453 |
|
| 2000 |
Mould AP, Askari JA, Humphries MJ. Molecular basis of ligand recognition by integrin alpha 5beta 1. I. Specificity of ligand binding is determined by amino acid sequences in the second and third NH2-terminal repeats of the alpha subunit. The Journal of Biological Chemistry. 275: 20324-36. PMID 10764748 DOI: 10.1074/Jbc.M000572200 |
0.419 |
|
| 2000 |
Humphries JD, Askari JA, Zhang XP, Takada Y, Humphries MJ, Mould AP. Molecular basis of ligand recognition by integrin alpha5beta 1. II. Specificity of arg-gly-Asp binding is determined by Trp157 OF THE alpha subunit. The Journal of Biological Chemistry. 275: 20337-45. PMID 10764747 DOI: 10.1074/Jbc.M000568200 |
0.43 |
|
| 2000 |
Lyon M, Rushton G, Askari JA, Humphries MJ, Gallagher JT. Elucidation of the structural features of heparan sulfate important for interaction with the Hep-2 domain of fibronectin. The Journal of Biological Chemistry. 275: 4599-606. PMID 10671486 DOI: 10.1074/Jbc.275.7.4599 |
0.377 |
|
| 2000 |
Humphries MJ. Integrin cell adhesion receptors and the concept of agonism. Trends in Pharmacological Sciences. 21: 29-32. PMID 10637653 DOI: 10.1016/S0165-6147(99)01410-8 |
0.441 |
|
| 2000 |
Tuckwell DS, Smith L, Korda M, Askari JA, Santoso S, Barnes MJ, Farndale RW, Humphries MJ. Monoclonal antibodies identify residues 199–216 of the integrin α2 vWFA domain as a functionally important region within α2β1 Biochemical Journal. 350: 485-493. DOI: 10.1042/Bj3500485 |
0.409 |
|
| 1999 |
Burrows L, Clark K, Mould AP, Humphries MJ. Fine mapping of inhibitory anti-alpha5 monoclonal antibody epitopes that differentially affect integrin-ligand binding. The Biochemical Journal. 344: 527-33. PMID 10567237 DOI: 10.1042/Bj3440527 |
0.49 |
|
| 1999 |
Ng T, Shima D, Squire A, Bastiaens PI, Gschmeissner S, Humphries MJ, Parker PJ. PKCalpha regulates beta1 integrin-dependent cell motility through association and control of integrin traffic. The Embo Journal. 18: 3909-23. PMID 10406796 DOI: 10.1093/Emboj/18.14.3909 |
0.435 |
|
| 1999 |
Vallés S, Tsoi C, Huang WY, Wyllie D, Carlotti F, Askari JA, Humphries MJ, Dower SK, Qwarnström EE. Recruitment of a heparan sulfate subunit to the interleukin-1 receptor complex. Regulation by fibronectin attachment. The Journal of Biological Chemistry. 274: 20103-9. PMID 10400621 DOI: 10.1074/Jbc.274.29.20103 |
0.35 |
|
| 1999 |
McCormick CJ, Tuckwell DS, Crisanti A, Humphries MJ, Hollingdale MR. Identification of heparin as a ligand for the A-domain of Plasmodium falciparum thrombospondin-related adhesion protein. Molecular and Biochemical Parasitology. 100: 111-24. PMID 10376999 DOI: 10.1016/S0166-6851(99)00052-3 |
0.408 |
|
| 1999 |
Sharma A, Askari JA, Humphries MJ, Jones EY, Stuart DI. Crystal structure of a heparin- and integrin-binding segment of human fibronectin. The Embo Journal. 18: 1468-79. PMID 10075919 DOI: 10.1093/Emboj/18.6.1468 |
0.382 |
|
| 1999 |
Ng TT, Collins IE, Kanner SB, Humphries MJ, Amft N, Wickremasinghe RG, D'Cruz D, Nye KE, Morrow WJ. Integrin signalling defects in T-lymphocytes in systemic lupus erythematosus. Lupus. 8: 39-51. PMID 10025598 DOI: 10.1191/096120399678847371 |
0.331 |
|
| 1999 |
Schofield KP, Humphries MJ. Identification of fibronectin IIICS variants in human bone marrow stroma. Blood. 93: 410-1. PMID 9935303 DOI: 10.1182/Blood.V93.1.410 |
0.378 |
|
| 1999 |
Mastrangelo AM, Homan SM, Humphries MJ, LaFlamme SE. Amino acid motifs required for isolated beta cytoplasmic domains to regulate 'in trans' beta1 integrin conformation and function in cell attachment. Journal of Cell Science. 112: 217-29. PMID 9858475 |
0.35 |
|
| 1999 |
Green LJ, Humphries MJ. The Molecular Anatomy of Integrins Advances in Molecular and Cell Biology. 28: 3-26. DOI: 10.1016/S1569-2558(08)60042-9 |
0.499 |
|
| 1998 |
McCutcheon JC, Hart SP, Canning M, Ross K, Humphries MJ, Dransfield I. Regulation of macrophage phagocytosis of apoptotic neutrophils by adhesion to fibronectin. Journal of Leukocyte Biology. 64: 600-7. PMID 9823764 DOI: 10.1002/Jlb.64.5.600 |
0.379 |
|
| 1998 |
Mould AP, Burrows L, Humphries MJ. Identification of amino acid residues that form part of the ligand-binding pocket of integrin alpha5 beta1. The Journal of Biological Chemistry. 273: 25664-72. PMID 9748233 DOI: 10.1074/Jbc.273.40.25664 |
0.442 |
|
| 1998 |
Fernandez C, Clark K, Burrows L, Schofield NR, Humphries MJ. Regulation of the extracellular ligand binding activity of integrins. Frontiers in Bioscience : a Journal and Virtual Library. 3: d684-700. PMID 9637803 DOI: 10.2741/A313 |
0.478 |
|
| 1998 |
Green LJ, Mould AP, Humphries MJ. The integrin beta subunit. The International Journal of Biochemistry & Cell Biology. 30: 179-84. PMID 9608671 DOI: 10.1016/S1357-2725(97)00107-6 |
0.5 |
|
| 1998 |
Newham P, Craig SE, Clark K, Mould AP, Humphries MJ. Analysis of ligand-induced and ligand-attenuated epitopes on the leukocyte integrin alpha4beta1: VCAM-1, mucosal addressin cell adhesion molecule-1, and fibronectin induce distinct conformational changes. Journal of Immunology (Baltimore, Md. : 1950). 160: 4508-17. PMID 9574557 |
0.393 |
|
| 1998 |
Mould AP, Garratt AN, Puzon-McLaughlin W, Takada Y, Humphries MJ. Regulation of integrin function: evidence that bivalent-cation-induced conformational changes lead to the unmasking of ligand-binding sites within integrin alpha5 beta1. The Biochemical Journal. 331: 821-8. PMID 9560310 DOI: 10.1042/Bj3310821 |
0.733 |
|
| 1998 |
Retta SF, Balzac F, Ferraris P, Belkin AM, Fässler R, Humphries MJ, De Leo G, Silengo L, Tarone G. beta1-integrin cytoplasmic subdomains involved in dominant negative function. Molecular Biology of the Cell. 9: 715-31. PMID 9529373 DOI: 10.1091/Mbc.9.4.715 |
0.403 |
|
| 1998 |
Messent AJ, Tuckwell DS, Knäuper V, Humphries MJ, Murphy G, Gavrilovic J. Effects of collagenase-cleavage of type I collagen on alpha2beta1 integrin-mediated cell adhesion. Journal of Cell Science. 111: 1127-35. PMID 9512508 |
0.351 |
|
| 1998 |
Schofield KP, Humphries MJ, Wynter Ed, Testa N, Gallagher JT. The Effect of α4β1-Integrin Binding Sequences of Fibronectin on Growth of Cells From Human Hematopoietic Progenitors Blood. 91: 3230-3238. DOI: 10.1182/Blood.V91.9.3230.3230_3230_3238 |
0.355 |
|
| 1997 |
Tselepis VH, Green LJ, Humphries MJ. An RGD to LDV motif conversion within the disintegrin kistrin generates an integrin antagonist that retains potency but exhibits altered receptor specificity. Evidence for a functional equivalence of acidic integrin-binding motifs. The Journal of Biological Chemistry. 272: 21341-8. PMID 9261147 DOI: 10.1074/Jbc.272.34.21341 |
0.435 |
|
| 1997 |
Newham P, Craig SE, Seddon GN, Schofield NR, Rees A, Edwards RM, Jones EY, Humphries MJ. Alpha4 integrin binding interfaces on VCAM-1 and MAdCAM-1. Integrin binding footprints identify accessory binding sites that play a role in integrin specificity. The Journal of Biological Chemistry. 272: 19429-40. PMID 9235944 DOI: 10.1074/Jbc.272.31.19429 |
0.526 |
|
| 1997 |
Mould AP, Askari JA, Aota Si, Yamada KM, Irie A, Takada Y, Mardon HJ, Humphries MJ. Defining the topology of integrin alpha5beta1-fibronectin interactions using inhibitory anti-alpha5 and anti-beta1 monoclonal antibodies. Evidence that the synergy sequence of fibronectin is recognized by the amino-terminal repeats of the alpha5 subunit. The Journal of Biological Chemistry. 272: 17283-92. PMID 9211865 DOI: 10.1074/Jbc.272.28.17283 |
0.442 |
|
| 1997 |
Lalor PF, Clements JM, Pigott R, Humphries MJ, Spragg JH, Nash GB. Association between receptor density, cellular activation, and transformation of adhesive behavior of flowing lymphocytes binding to VCAM-1. European Journal of Immunology. 27: 1422-6. PMID 9209494 DOI: 10.1002/Eji.1830270619 |
0.486 |
|
| 1997 |
Davies D, Tuckwell DS, Calderwood DA, Weston SA, Takigawa M, Humphries MJ. Molecular characterisation of integrin-procollagen C-propeptide interactions. European Journal of Biochemistry / Febs. 246: 274-82. PMID 9208915 DOI: 10.1111/J.1432-1033.1997.T01-1-00274.X |
0.49 |
|
| 1997 |
Tuckwell DS, Xu Y, Newham P, Humphries MJ, Volanakis JE. Surface loops adjacent to the cation-binding site of the complement factor B von Willebrand factor type A module determine C3b binding specificity. Biochemistry. 36: 6605-13. PMID 9184140 DOI: 10.1021/Bi963155L |
0.366 |
|
| 1997 |
Beauvais-Jouneau A, Delouvée A, Craig SE, Humphries MJ, Thiery JP, Dufour S. Direct role of the carboxy-terminal cell-binding domain of fibronectin in neural crest cell motility. Experimental Cell Research. 233: 1-10. PMID 9184069 DOI: 10.1006/Excr.1997.3554 |
0.481 |
|
| 1997 |
Barry ST, Flinn HM, Humphries MJ, Critchley DR, Ridley AJ. Requirement for Rho in integrin signalling. Cell Adhesion and Communication. 4: 387-98. PMID 9177901 DOI: 10.3109/15419069709004456 |
0.443 |
|
| 1997 |
Calderwood DA, Tuckwell DS, Eble J, Kühn K, Humphries MJ. The integrin alpha1 A-domain is a ligand binding site for collagens and laminin. The Journal of Biological Chemistry. 272: 12311-7. PMID 9139675 DOI: 10.1074/Jbc.272.19.12311 |
0.448 |
|
| 1997 |
Tuckwell DS, Humphries MJ. A structure prediction for the ligand-binding region of the integrin beta subunit: evidence for the presence of a von Willebrand factor A domain. Febs Letters. 400: 297-303. PMID 9009218 DOI: 10.1016/S0014-5793(96)01368-3 |
0.457 |
|
| 1997 |
Schofield KP, Rushton G, Humphries MJ, Dexter TM, Gallagher JT. Influence of Interleukin-3 and Other Growth Factors on α4β1 Integrin-Mediated Adhesion and Migration of Human Hematopoietic Progenitor Cells Blood. 90: 1858-1866. DOI: 10.1182/Blood.V90.5.1858 |
0.401 |
|
| 1996 |
Tuckwell DS, Reid KB, Barnes MJ, Humphries MJ. The A-domain of integrin alpha 2 binds specifically to a range of collagens but is not a general receptor for the collagenous motif. European Journal of Biochemistry / Febs. 241: 732-9. PMID 8944759 DOI: 10.1111/J.1432-1033.1996.00732.X |
0.46 |
|
| 1996 |
Humphries MJ. Integrin activation: the link between ligand binding and signal transduction. Current Opinion in Cell Biology. 8: 632-40. PMID 8939662 DOI: 10.1016/S0955-0674(96)80104-9 |
0.472 |
|
| 1996 |
Schor SL, Ellis I, Dolman C, Banyard J, Humphries MJ, Mosher DF, Grey AM, Mould AP, Sottile J, Schor AM. Substratum-dependent stimulation of fibroblast migration by the gelatin-binding domain of fibronectin. Journal of Cell Science. 109: 2581-90. PMID 8923219 |
0.331 |
|
| 1996 |
Newham P, Humphries MJ. Integrin adhesion receptors: structure, function and implications for biomedicine. Molecular Medicine Today. 2: 304-13. PMID 8796911 DOI: 10.1016/1357-4310(96)10021-6 |
0.459 |
|
| 1996 |
Mould AP, Akiyama SK, Humphries MJ. The inhibitory anti-beta1 integrin monoclonal antibody 13 recognizes an epitope that is attenuated by ligand occupancy. Evidence for allosteric inhibition of integrin function. The Journal of Biological Chemistry. 271: 20365-74. PMID 8702772 DOI: 10.1074/Jbc.271.34.20365 |
0.418 |
|
| 1996 |
Frankel G, Lider O, Hershkoviz R, Mould AP, Kachalsky SG, Candy DC, Cahalon L, Humphries MJ, Dougan G. The cell-binding domain of intimin from enteropathogenic Escherichia coli binds to beta1 integrins. The Journal of Biological Chemistry. 271: 20359-64. PMID 8702771 DOI: 10.1074/Jbc.271.34.20359 |
0.497 |
|
| 1996 |
Chambers MA, Dougan G, Newman J, Brown F, Crowther J, Mould AP, Humphries MJ, Francis MJ, Clarke B, Brown AL, Rowlands D. Chimeric hepatitis B virus core particles as probes for studying peptide-integrin interactions. Journal of Virology. 70: 4045-52. PMID 8648742 DOI: 10.1128/Jvi.70.6.4045-4052.1996 |
0.342 |
|
| 1996 |
Hukins DWL, Weston SA, Humphries MJ, Freemont AJ. Chapter 8 Extracellular matrix Principles of Medical Biology. 3: 181-232. DOI: 10.1016/S1569-2582(05)80039-X |
0.417 |
|
| 1996 |
Tuckwell D, Humphries MJ. Integrin–collagen binding Seminars in Cell & Developmental Biology. 7: 649-657. DOI: 10.1006/Scdb.1996.0079 |
0.437 |
|
| 1995 |
Garratt AN, Humphries MJ. Recent insights into ligand binding, activation and signalling by integrin adhesion receptors. Acta Anatomica. 154: 34-45. PMID 8714288 DOI: 10.1159/000147750 |
0.752 |
|
| 1995 |
Davies D, Tuckwell DS, Watson RB, Weston SA, Humphries MJ. Regulation of extracellular matrix deposition by the C-propeptide domain of fibrillar collagens. Biochemical Society Transactions. 23: 516S. PMID 8654701 DOI: 10.1042/Bst023516S |
0.313 |
|
| 1995 |
Green LJ, Brierley VH, Humphries MJ. Inhibition of integrin-ligand binding by recombinant kistrins. Biochemical Society Transactions. 23: 505S. PMID 8654690 DOI: 10.1042/Bst023505S |
0.39 |
|
| 1995 |
Calderwood DA, Tuckwell DS, Humphries MJ. Specificity of integrin I-domain-ligand binding. Biochemical Society Transactions. 23: 504S. PMID 8654689 DOI: 10.1042/Bst023504S |
0.396 |
|
| 1995 |
Mould AP, Garratt AN, Askari JA, Akiyama SK, Humphries MJ. Regulation of integrin alpha 5 beta 1 function by anti-integrin antibodies and divalent cations. Biochemical Society Transactions. 23: 395S. PMID 8566283 DOI: 10.1042/Bst023395S |
0.686 |
|
| 1995 |
Altevogt P, Hubbe M, Ruppert M, Lohr J, von Hoegen P, Sammar M, Andrew DP, McEvoy L, Humphries MJ, Butcher EC. The alpha 4 integrin chain is a ligand for alpha 4 beta 7 and alpha 4 beta 1. The Journal of Experimental Medicine. 182: 345-55. PMID 7629498 DOI: 10.1084/Jem.182.2.345 |
0.443 |
|
| 1995 |
Tuckwell D, Calderwood DA, Green LJ, Humphries MJ. Integrin alpha 2 I-domain is a binding site for collagens. Journal of Cell Science. 108: 1629-37. PMID 7615681 |
0.312 |
|
| 1995 |
Mould AP, Akiyama SK, Humphries MJ. Regulation of integrin alpha 5 beta 1-fibronectin interactions by divalent cations. Evidence for distinct classes of binding sites for Mn2+, Mg2+, and Ca2+. The Journal of Biological Chemistry. 270: 26270-7. PMID 7592835 DOI: 10.1074/Jbc.270.44.26270 |
0.399 |
|
| 1995 |
Humphries MJ, Sheridan J, Mould AP, Newham P. Mechanisms of VCAM-1 and fibronectin binding to integrin alpha 4 beta 1: implications for integrin function and rational drug design. Ciba Foundation Symposium. 189: 177-91; discussion 1. PMID 7587632 |
0.417 |
|
| 1995 |
Huhtala P, Humphries MJ, McCarthy JB, Tremble PM, Werb Z, Damsky CH. Cooperative signaling by alpha 5 beta 1 and alpha 4 beta 1 integrins regulates metalloproteinase gene expression in fibroblasts adhering to fibronectin. The Journal of Cell Biology. 129: 867-79. PMID 7537277 DOI: 10.1083/Jcb.129.3.867 |
0.472 |
|
| 1995 |
Mould AP, Garratt AN, Askari JA, Akiyama SK, Humphries MJ. Identification of a novel anti-integrin monoclonal antibody that recognises a ligand-induced binding site epitope on the beta 1 subunit. Febs Letters. 363: 118-22. PMID 7537221 DOI: 10.1016/0014-5793(95)00301-O |
0.74 |
|
| 1995 |
Beauvais A, Erickson CA, Goins T, Craig SE, Humphries MJ, Thiery JP, Dufour S. Changes in the fibronectin-specific integrin expression pattern modify the migratory behavior of sarcoma S180 cells in vitro and in the embryonic environment. The Journal of Cell Biology. 128: 699-713. PMID 7532177 DOI: 10.1083/Jcb.128.4.699 |
0.472 |
|
| 1994 |
Humphries MJ. Mechanisms of ligand binding by integrins. Biochemical Society Transactions. 22: 275-82. PMID 7958306 DOI: 10.1042/Bst0220275 |
0.388 |
|
| 1994 |
Tuckwell DS, Humphries MJ, Brass A. A secondary structure model of the integrin alpha subunit N-terminal domain based on analysis of multiple alignments. Cell Adhesion and Communication. 2: 385-402. PMID 7842254 DOI: 10.3109/15419069409004450 |
0.407 |
|
| 1994 |
Dudgeon TJ, Bottomley MJ, Driscoll PC, Humphries MJ, Mould AP, Wingfield GI, Clements JM. Expression and characterisation of a very-late antigen-4 (alpha 4 beta 1) integrin-binding fragment of vascular cell-adhesion molecule-1. European Journal of Biochemistry / Febs. 226: 517-23. PMID 7528140 DOI: 10.1111/J.1432-1033.1994.Tb20076.X |
0.451 |
|
| 1994 |
Clements JM, Newham P, Shepherd M, Gilbert R, Dudgeon TJ, Needham LA, Edwards RM, Berry L, Brass A, Humphries MJ. Identification of a key integrin-binding sequence in VCAM-1 homologous to the LDV active site in fibronectin. Journal of Cell Science. 107: 2127-35. PMID 7527054 |
0.388 |
|
| 1994 |
Mould AP, Askari JA, Craig SE, Garratt AN, Clements J, Humphries MJ. Integrin alpha 4 beta 1-mediated melanoma cell adhesion and migration on vascular cell adhesion molecule-1 (VCAM-1) and the alternatively spliced IIICS region of fibronectin. The Journal of Biological Chemistry. 269: 27224-30. PMID 7525548 |
0.756 |
|
| 1994 |
Weston SA, Hulmes DJ, Mould AP, Watson RB, Humphries MJ. Identification of integrin alpha 2 beta 1 as cell surface receptor for the carboxyl-terminal propeptide of type I procollagen. The Journal of Biological Chemistry. 269: 20982-6. PMID 7520435 |
0.387 |
|
| 1994 |
Tuckwell DS, Ayad S, Grant ME, Takigawa M, Humphries MJ. Conformation dependence of integrin-type II collagen binding. Inability of collagen peptides to support alpha 2 beta 1 binding, and mediation of adhesion to denatured collagen by a novel alpha 5 beta 1-fibronectin bridge. Journal of Cell Science. 107: 993-1005. PMID 7520045 |
0.388 |
|
| 1994 |
Morton LF, Peachey AR, Zijenah LS, Goodall AH, Humphries MJ, Barnes MJ. Conformation-dependent platelet adhesion to collagen involving integrin alpha 2 beta 1-mediated and other mechanisms: multiple alpha 2 beta 1-recognition sites in collagen type I. The Biochemical Journal. 299: 791-7. PMID 7514871 DOI: 10.1042/Bj2990791 |
0.412 |
|
| 1994 |
Makarem R, Newham P, Askari JA, Green LJ, Clements J, Edwards M, Humphries MJ, Mould AP. Competitive binding of vascular cell adhesion molecule-1 and the HepII/IIICS domain of fibronectin to the integrin alpha 4 beta 1. The Journal of Biological Chemistry. 269: 4005-11. PMID 7508437 |
0.441 |
|
| 1994 |
Humphries MJ, Doyle PM, Harris CJ. Overview biologicals and immunologicals: Integrin antagonists as modulators of adhesion Expert Opinion On Therapeutic Patents. 4: 227-235. DOI: 10.1517/13543776.4.3.227 |
0.357 |
|
| 1994 |
Humphries MJ, Mould AP, Weston SA. Conjugation of synthetic peptides to carrier proteins for cell adhesion studies Journal of Tissue Culture Methods. 16: 239-242. DOI: 10.1007/Bf01540659 |
0.316 |
|
| 1993 |
Humphries MJ, Mould AP, Tuckwell DS. Dynamic aspects of adhesion receptor function--integrins both twist and shout. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 15: 391-7. PMID 8357341 DOI: 10.1002/Bies.950150605 |
0.495 |
|
| 1993 |
Tuckwell DS, Weston SA, Humphries MJ. Integrins: a review of their structure and mechanisms of ligand binding. Symposia of the Society For Experimental Biology. 47: 107-36. PMID 8165561 |
0.408 |
|
| 1993 |
Newham P, Tuckwell DS, Brass A, Humphries MJ. Mechanism of integrin alpha 4 beta 1-VCAM-1 interaction. Biochemical Society Transactions. 21: 339S. PMID 7510643 DOI: 10.1042/Bst021339S |
0.38 |
|
| 1992 |
Humphries MJ. Peptide recognition motifs involved in the binding of integrins to their ligands. Kidney International. 41: 645-9. PMID 1573842 DOI: 10.1038/Ki.1992.99 |
0.503 |
|
| 1992 |
Yoshihara T, Esumi N, Humphries MJ, Imashuku S. Unique expression of integrin fibronectin receptors in human neuroblastoma cell lines. International Journal of Cancer. Journal International Du Cancer. 51: 620-6. PMID 1534785 DOI: 10.1002/Ijc.2910510419 |
0.419 |
|
| 1992 |
Szekanecz Z, Humphries MJ, Ager A. Lymphocyte adhesion to high endothelium is mediated by two beta 1 integrin receptors for fibronectin, alpha 4 beta 1 and alpha 5 beta 1. Journal of Cell Science. 101: 885-94. PMID 1388178 |
0.382 |
|
| 1992 |
Rodriguez RM, Pitzalis C, Kingsley GH, Henderson E, Humphries MJ, Panayi GS. T lymphocyte adhesion to fibronectin (FN): a possible mechanism for T cell accumulation in the rheumatoid joint. Clinical and Experimental Immunology. 89: 439-45. PMID 1387596 DOI: 10.1111/J.1365-2249.1992.Tb06977.X |
0.419 |
|
| 1992 |
Tuckwell DS, Brass A, Humphries MJ. Homology modelling of integrin EF-hands. Evidence for widespread use of a conserved cation-binding site. The Biochemical Journal. 285: 325-31. PMID 1322124 DOI: 10.1042/Bj2850325 |
0.389 |
|
| 1991 |
Yoshihara T, Ikushima S, Shimizu Y, Esumi N, Todo S, Humphries MJ, Imashuku S. Distinct mechanism of human neuroblastoma cell adhesion to fibronectin. Clinical & Experimental Metastasis. 9: 363-75. PMID 1831074 DOI: 10.1007/Bf01769356 |
0.44 |
|
| 1991 |
Morton LF, Zijenah LS, McCulloch IY, Knight CG, Humphries MJ, Barnes MJ. Integrin-dependent platelet recognition sites in collagen: identification of a short platelet-reactive sequence in the type III-derived fragment alpha 1(III) CB3. Biochemical Society Transactions. 19: 439S. PMID 1794556 DOI: 10.1042/Bst019439S |
0.318 |
|
| 1991 |
Tuckwell DS, Allen MD, Takigawa M, Humphries MJ. Novel methods for the study of cell-collagen interactions. Biochemical Society Transactions. 19: 370S. PMID 1794504 DOI: 10.1042/Bst019370S |
0.337 |
|
| 1991 |
Ager A, Humphries MJ. Integrin alpha 4 beta 1: its structure, ligand-binding specificity and role in lymphocyte-endothelial cell interactions. Chemical Immunology. 50: 55-74. PMID 1786107 DOI: 10.1159/000319056 |
0.486 |
|
| 1991 |
Mould AP, Humphries MJ. Identification of a novel recognition sequence for the integrin alpha 4 beta 1 in the COOH-terminal heparin-binding domain of fibronectin. The Embo Journal. 10: 4089-95. PMID 1756719 DOI: 10.1002/J.1460-2075.1991.Tb04985.X |
0.466 |
|
| 1991 |
Mould AP, Komoriya A, Yamada KM, Humphries MJ. The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues. The Journal of Biological Chemistry. 266: 3579-85. PMID 1750929 |
0.34 |
|
| 1991 |
Makarem R, Humphries MJ. LDV: a novel cell adhesion motif recognized by the integrin alpha 4 beta 1. Biochemical Society Transactions. 19: 380S. PMID 1724433 DOI: 10.1042/Bst019380S |
0.447 |
|
| 1990 |
Mould AP, Wheldon LA, Komoriya A, Wayner EA, Yamada KM, Humphries MJ. Affinity chromatographic isolation of the melanoma adhesion receptor for the IIICS region of fibronectin and its identification as the integrin alpha 4 beta 1. The Journal of Biological Chemistry. 265: 4020-4. PMID 2137460 |
0.402 |
|
| 1990 |
Ager A, Humphries MJ. Use of synthetic peptides to probe lymphocyte--high endothelial cell interactions. Lymphocytes recognize a ligand on the endothelial surface which contains the CS1 adhesion motif. International Immunology. 2: 921-8. PMID 2078520 DOI: 10.1093/Intimm/2.10.921 |
0.427 |
|
| 1990 |
Nojima Y, Humphries MJ, Mould AP, Komoriya A, Yamada KM, Schlossman SF, Morimoto C. VLA-4 mediates CD3-dependent CD4+ T cell activation via the CS1 alternatively spliced domain of fibronectin. The Journal of Experimental Medicine. 172: 1185-92. PMID 1976737 DOI: 10.1084/Jem.172.4.1185 |
0.301 |
|
| 1989 |
Humphries MJ, Obara M, Olden K, Yamada KM. Role of fibronectin in adhesion, migration, and metastasis. Cancer Investigation. 7: 373-93. PMID 2531625 DOI: 10.3109/07357908909039866 |
0.418 |
|
| 1989 |
Wayner EA, Garcia-Pardo A, Humphries MJ, McDonald JA, Carter WG. Identification and characterization of the T lymphocyte adhesion receptor for an alternative cell attachment domain (CS-1) in plasma fibronectin. The Journal of Cell Biology. 109: 1321-30. PMID 2527858 DOI: 10.1083/Jcb.109.3.1321 |
0.463 |
|
| 1988 |
Humphries MJ, Akiyama SK, Komoriya A, Olden K, Yamada KM. Neurite extension of chicken peripheral nervous system neurons on fibronectin: relative importance of specific adhesion sites in the central cell-binding domain and the alternatively spliced type III connecting segment. The Journal of Cell Biology. 106: 1289-97. PMID 3360854 DOI: 10.1083/Jcb.106.4.1289 |
0.461 |
|
| 1988 |
Humphries MJ, Yamada KM, Olden K. Investigation of the biological effects of anti-cell adhesive synthetic peptides that inhibit experimental metastasis of B16-F10 murine melanoma cells. The Journal of Clinical Investigation. 81: 782-90. PMID 3343338 DOI: 10.1172/Jci113384 |
0.368 |
|
| 1988 |
Dufour S, Duband JL, Humphries MJ, Obara M, Yamada KM, Thiery JP. Attachment, spreading and locomotion of avian neural crest cells are mediated by multiple adhesion sites on fibronectin molecules. The Embo Journal. 7: 2661-71. PMID 3181137 DOI: 10.1002/J.1460-2075.1988.Tb03119.X |
0.452 |
|
| 1988 |
White SL, Schweitzer K, Humphries MJ, Olden K. Stimulation of DNA synthesis in murine lymphocytes by the drug swainsonine: immunomodulatory properties. Biochemical and Biophysical Research Communications. 150: 615-25. PMID 3124836 DOI: 10.1016/0006-291X(88)90437-8 |
0.316 |
|
| 1988 |
Humphries MJ, Yasuda Y, Olden K, Yamada KM. The cell interaction sites of fibronectin in tumour metastasis. Ciba Foundation Symposium. 141: 75-93. PMID 2855415 DOI: 10.1002/9780470513736.ch5 |
0.309 |
|
| 1986 |
Humphries MJ, Olden K, Yamada KM. A synthetic peptide from fibronectin inhibits experimental metastasis of murine melanoma cells. Science (New York, N.Y.). 233: 467-70. PMID 3726541 DOI: 10.1126/Science.3726541 |
0.386 |
|
| 1986 |
Humphries MJ, Matsumoto K, White SL, Olden K. Oligosaccharide modification by swainsonine treatment inhibits pulmonary colonization by B16-F10 murine melanoma cells. Proceedings of the National Academy of Sciences of the United States of America. 83: 1752-6. PMID 3081900 DOI: 10.1073/Pnas.83.6.1752 |
0.331 |
|
| 1986 |
Humphries MJ, Akiyama SK, Komoriya A, Olden K, Yamada KM. Identification of an alternatively spliced site in human plasma fibronectin that mediates cell type-specific adhesion. The Journal of Cell Biology. 103: 2637-47. PMID 3025221 DOI: 10.1083/Jcb.103.6.2637 |
0.455 |
|
| 1985 |
Nagata K, Humphries MJ, Olden K, Yamada KM. Collagen can modulate cell interactions with fibronectin. The Journal of Cell Biology. 101: 386-94. PMID 3160713 DOI: 10.1083/Jcb.101.2.386 |
0.45 |
|
| 1985 |
Yamada KM, Akiyama SK, Hasegawa T, Hasegawa E, Humphries MJ, Kennedy DW, Nagata K, Urushihara H, Olden K, Chen WT. Recent advances in research on fibronectin and other cell attachment proteins. Journal of Cellular Biochemistry. 28: 79-97. PMID 3001108 DOI: 10.1002/Jcb.240280202 |
0.364 |
|
| 1985 |
Olden K, Bernard BA, Humphries MJ, Yeo T, Yeo K, White SL, Newton SA, Bauer HC, Parent JB. Function of glycoprotein glycans. Trends in Biochemical Sciences. 10: 78-82. DOI: 10.1016/0968-0004(85)90238-5 |
0.332 |
|
| 1983 |
Humphries MJ, Ayad SR. Stimulation of DNA synthesis by cathepsin D digests of fibronectin. Nature. 305: 811-3. PMID 6633653 DOI: 10.1038/305811A0 |
0.349 |
|
| Show low-probability matches. |