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Angela M. Lam, Ph.D. - Publications

Affiliations: 
2001 University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Biochemistry, Molecular Biology
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41 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Lam AM, Dugyala RR, Sheraz M, Liu F, Thi EP, Graves IE, Cuconati A, Steuer HM, Ardzinski A, Overholt N, Mason JD, Gotchev D, Cole AG, Harasym TO, Sofia MJ. Preclinical Antiviral and Safety Profiling of the HBV RNA Destabilizer AB-161. Viruses. 16. PMID 38543689 DOI: 10.3390/v16030323  0.303
2022 Zhao Q, Chang J, Rijnbrand R, Lam AM, Sofia MJ, Cuconati A, Guo JT. Pregenomic RNA Launch Hepatitis B Virus Replication System Facilitates the Mechanistic Study of Antiviral Agents and Drug-Resistant Variants on Covalently Closed Circular DNA Synthesis. Journal of Virology. e0115022. PMID 36448800 DOI: 10.1128/jvi.01150-22  0.301
2020 Hartman GD, Kuduk SD, Espiritu C, Lam AM. 450s nder striction (PURE) Screen Using HepaRG and Primary Human Hepatocytes for Discovery of Novel HBV Antivirals. Acs Medicinal Chemistry Letters. 11: 1919-1927. PMID 33062174 DOI: 10.1021/Acsmedchemlett.9B00630  0.351
2019 Kuduk SD, Lam AM, Espiritu C, Vogel R, Lau V, Klumpp K, Flores OA, Hartman GD. SAR studies in the sulfonyl carboxamide class of HBV capsid assembly modulators. Bioorganic & Medicinal Chemistry Letters. PMID 31227344 DOI: 10.1016/J.Bmcl.2019.05.029  0.331
2018 Lam AM, Espiritu C, Vogel R, Ren S, Lau V, Kelly M, Kuduk SD, Hartman GD, Flores OA, Klumpp K. Preclinical Characterization of NVR 3-778, a First-in-Class Capsid Assembly Modulator Against the Hepatitis B Virus. Antimicrobial Agents and Chemotherapy. PMID 30373799 DOI: 10.1128/Aac.01734-18  0.445
2017 Klumpp K, Shimada T, Allweiss L, Volz T, Lütgehetmann M, Hartman G, Flores OA, Lam AM, Dandri M. Efficacy of NVR 3-778, Alone and in Combination With Pegylated Interferon, vs Entecavir in uPA/SCID Mice With Humanized Livers and HBV Infection. Gastroenterology. PMID 29079518 DOI: 10.1053/J.Gastro.2017.10.017  0.326
2017 Lam AM, Ren S, Espiritu C, Kelly M, Lau V, Zheng L, Hartman GD, Flores OA, Klumpp K. HBV Capsid Assembly Modulators, but not Nucleoside Analogs, Inhibit the Production of Extracellular Pregenomic RNA and Spliced RNA Variants. Antimicrobial Agents and Chemotherapy. PMID 28559265 DOI: 10.1128/Aac.00680-17  0.395
2015 Klumpp K, Lam AM, Lukacs C, Vogel R, Ren S, Espiritu C, Baydo R, Atkins K, Abendroth J, Liao G, Efimov A, Hartman G, Flores OA. High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein. Proceedings of the National Academy of Sciences of the United States of America. PMID 26598693 DOI: 10.1073/Pnas.1513803112  0.366
2015 Lam A, Espiritu C, Flores O, Hartman G, Klumpp K. P0640 : Effect of the combination of the HBV core inhibitor NVR 3-778 with nucleoside analogs or other HBV core inhibitors on the inhibition of HBV DNA replication in HepG2.2.15 cells Journal of Hepatology. 62. DOI: 10.1016/S0168-8278(15)30845-X  0.378
2015 Klumpp K, Shimada T, Allweiss L, Volz T, Luetgehetman M, Flores O, Hartman G, Lam A, Dandri M. O115 : High antiviral activity of the HBV core inhibitor NVR 3-778 in the humanized uPA/SCID mouse model Journal of Hepatology. 62: S250. DOI: 10.1016/S0168-8278(15)30134-3  0.32
2014 Lam AM, Edwards TE, Mosley RT, Murakami E, Bansal S, Lugo C, Bao H, Otto MJ, Sofia MJ, Furman PA. Molecular and structural basis for the roles of hepatitis C virus polymerase NS5B amino acids 15, 223, and 321 in viral replication and drug resistance. Antimicrobial Agents and Chemotherapy. 58: 6861-9. PMID 25182647 DOI: 10.1128/Aac.03847-14  0.429
2014 Kakarla R, Liu J, Naduthambi D, Chang W, Mosley RT, Bao D, Steuer HM, Keilman M, Bansal S, Lam AM, Seibel W, Neilson S, Furman PA, Sofia MJ. Discovery of a novel class of potent HCV NS4B inhibitors: SAR studies on piperazinone derivatives. Journal of Medicinal Chemistry. 57: 2136-60. PMID 24476391 DOI: 10.1021/Jm4012643  0.44
2014 Du J, Chun BK, Mosley RT, Bansal S, Bao H, Espiritu C, Lam AM, Murakami E, Niu C, Micolochick Steuer HM, Furman PA, Sofia MJ. Use of 2'-spirocyclic ethers in HCV nucleoside design. Journal of Medicinal Chemistry. 57: 1826-35. PMID 24079820 DOI: 10.1021/Jm401224Y  0.448
2012 Du J, Bao D, Chun BK, Jiang Y, Reddy PG, Zhang HR, Ross BS, Bansal S, Bao H, Espiritu C, Lam AM, Murakami E, Niu C, Micolochick Steuer HM, Furman PA, et al. β-D-2'-α-F-2'-β-C-Methyl-6-O-substituted 3',5'-cyclic phosphate nucleotide prodrugs as inhibitors of hepatitis C virus replication: a structure-activity relationship study. Bioorganic & Medicinal Chemistry Letters. 22: 5924-9. PMID 22892115 DOI: 10.1016/J.Bmcl.2012.07.066  0.471
2012 Niu C, Tolstykh T, Bao H, Park Y, Babusis D, Lam AM, Bansal S, Du J, Chang W, Reddy PG, Zhang HR, Woolley J, Wang LQ, Chao PB, Ray AS, et al. Metabolic activation of the anti-hepatitis C virus nucleotide prodrug PSI-352938. Antimicrobial Agents and Chemotherapy. 56: 3767-75. PMID 22526308 DOI: 10.1128/Aac.00530-12  0.438
2012 Mosley RT, Edwards TE, Murakami E, Lam AM, Grice RL, Du J, Sofia MJ, Furman PA, Otto MJ. Structure of hepatitis C virus polymerase in complex with primer-template RNA. Journal of Virology. 86: 6503-11. PMID 22496223 DOI: 10.1128/Jvi.00386-12  0.434
2012 Lam AM, Espiritu C, Bansal S, Micolochick Steuer HM, Niu C, Zennou V, Keilman M, Zhu Y, Lan S, Otto MJ, Furman PA. Genotype and subtype profiling of PSI-7977 as a nucleotide inhibitor of hepatitis C virus. Antimicrobial Agents and Chemotherapy. 56: 3359-68. PMID 22430955 DOI: 10.1128/Aac.00054-12  0.352
2012 Chang W, Mosley RT, Bansal S, Keilman M, Lam AM, Furman PA, Otto MJ, Sofia MJ. Inhibition of hepatitis C virus NS5A by fluoro-olefin based γ-turn mimetics. Bioorganic & Medicinal Chemistry Letters. 22: 2938-42. PMID 22425564 DOI: 10.1016/J.Bmcl.2012.02.051  0.452
2011 Chang W, Bao D, Chun BK, Naduthambi D, Nagarathnam D, Rachakonda S, Reddy PG, Ross BS, Zhang HR, Bansal S, Espiritu CL, Keilman M, Lam AM, Niu C, Steuer HM, et al. Discovery of PSI-353661, a Novel Purine Nucleotide Prodrug for the Treatment of HCV Infection. Acs Medicinal Chemistry Letters. 2: 130-5. PMID 24900291 DOI: 10.1021/Ml100209F  0.477
2011 Lam AM, Espiritu C, Bansal S, Micolochick Steuer HM, Zennou V, Otto MJ, Furman PA. Hepatitis C virus nucleotide inhibitors PSI-352938 and PSI-353661 exhibit a novel mechanism of resistance requiring multiple mutations within replicon RNA. Journal of Virology. 85: 12334-42. PMID 21957306 DOI: 10.1128/Jvi.05639-11  0.449
2011 Furman PA, Murakami E, Niu C, Lam AM, Espiritu C, Bansal S, Bao H, Tolstykh T, Micolochick Steuer H, Keilman M, Zennou V, Bourne N, Veselenak RL, Chang W, Ross BS, et al. Activity and the metabolic activation pathway of the potent and selective hepatitis C virus pronucleotide inhibitor PSI-353661. Antiviral Research. 91: 120-32. PMID 21600932 DOI: 10.1016/J.Antiviral.2011.05.003  0.453
2011 Lam AM, Espiritu C, Murakami E, Zennou V, Bansal S, Micolochick Steuer HM, Niu C, Keilman M, Bao H, Bourne N, Veselenak RL, Reddy PG, Chang W, Du J, Nagarathnam D, et al. Inhibition of hepatitis C virus replicon RNA synthesis by PSI-352938, a cyclic phosphate prodrug of β-D-2'-deoxy-2'-α-fluoro-2'-β-C-methylguanosine. Antimicrobial Agents and Chemotherapy. 55: 2566-75. PMID 21444700 DOI: 10.1128/Aac.00032-11  0.523
2011 Lam AM, Espíritu C, Bansal S, Steuer HMM, Zennou V, Otto MJ, Furman PA. 1217 MECHANISM OF HCV REPLICÓN RESISTANCE TO PSI-352938, A CYCLIC MONOPHOSPHATE PRODRUG OF 2'-α-F-2'-β-C-METHYLGUANOSINE Journal of Hepatology. 54. DOI: 10.1016/S0168-8278(11)61219-1  0.383
2011 Murakami E, Bao H, Lam AM, Espiritu C, Bansal S, Furman PA. A Comparison of the ability of wild-type and S282T mutant HCV NS5B to incorporate 2′-α-F-2′-β-C-methylguanosine-5′-monophosphate and 2′-α-OH-2′-β-C-methylguanosine-5′-monophosphate Antiviral Research. 90. DOI: 10.1016/J.Antiviral.2011.03.157  0.366
2011 Lam AM, Espiritu C, Bansal S, Steuer HMM, Zennou V, Otto MJ, Furman PA. In vitro Selection of HCV Replicons with Reduced Sensitivity to PSI-352938, A Cyclicphosphate Prodrug of β-d-2′-α-F-2′-β-C-Methylguanosine Antiviral Research. 90. DOI: 10.1016/J.Antiviral.2011.03.004  0.373
2010 Reddy PG, Bao D, Chang W, Chun BK, Du J, Nagarathnam D, Rachakonda S, Ross BS, Zhang HR, Bansal S, Espiritu CL, Keilman M, Lam AM, Niu C, Steuer HM, et al. 2'-deoxy-2'-α-fluoro-2'-β-C-methyl 3',5'-cyclic phosphate nucleotide prodrug analogs as inhibitors of HCV NS5B polymerase: discovery of PSI-352938. Bioorganic & Medicinal Chemistry Letters. 20: 7376-80. PMID 21050754 DOI: 10.1016/J.Bmcl.2010.10.035  0.452
2010 Sofia MJ, Bao D, Chang W, Du J, Nagarathnam D, Rachakonda S, Reddy PG, Ross BS, Wang P, Zhang HR, Bansal S, Espiritu C, Keilman M, Lam AM, Steuer HM, et al. Discovery of a β-d-2'-deoxy-2'-α-fluoro-2'-β-C-methyluridine nucleotide prodrug (PSI-7977) for the treatment of hepatitis C virus. Journal of Medicinal Chemistry. 53: 7202-18. PMID 20845908 DOI: 10.1021/Jm100863X  0.474
2010 Murakami E, Tolstykh T, Bao H, Niu C, Steuer HM, Bao D, Chang W, Espiritu C, Bansal S, Lam AM, Otto MJ, Sofia MJ, Furman PA. Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977. The Journal of Biological Chemistry. 285: 34337-47. PMID 20801890 DOI: 10.1074/Jbc.M110.161802  0.478
2010 Lam AM, Murakami E, Espiritu C, Steuer HM, Niu C, Keilman M, Bao H, Zennou V, Bourne N, Julander JG, Morrey JD, Smee DF, Frick DN, Heck JA, Wang P, et al. PSI-7851, a pronucleotide of beta-D-2'-deoxy-2'-fluoro-2'-C-methyluridine monophosphate, is a potent and pan-genotype inhibitor of hepatitis C virus replication. Antimicrobial Agents and Chemotherapy. 54: 3187-96. PMID 20516278 DOI: 10.1128/Aac.00399-10  0.495
2010 Frick DN, Ginzburg O, Lam AM. A method to simultaneously monitor hepatitis C virus NS3 helicase and protease activities. Methods in Molecular Biology (Clifton, N.J.). 587: 223-33. PMID 20225153 DOI: 10.1007/978-1-60327-355-8_16  0.353
2010 Zennou V, Lam A, Keilman M, Steuer HM, Espiritu C, Sofia M, Reddy P, Chang W, Rachakonda S, Otto M, Furman P. 1034 COMBINATION OF TWO COMPLEMENTARY NUCLEOTIDE ANALOGUES PSI-7977 AND PSI-938 EFFECTIVELY CLEARS WILD TYPE AND NS5B:S282T HCV REPLICONS – COMPARISON WITH COMBINATIONS OF OTHER ANTIVIRAL COMPOUNDS Journal of Hepatology. 52: S400-S401. DOI: 10.1016/S0168-8278(10)61035-5  0.43
2009 Furman PA, Lam AM, Murakami E. Nucleoside analog inhibitors of hepatitis C viral replication: recent advances, challenges and trends. Future Medicinal Chemistry. 1: 1429-52. PMID 21426058 DOI: 10.4155/Fmc.09.88  0.471
2008 Heck JA, Lam AM, Narayanan N, Frick DN. Effects of mutagenic and chain-terminating nucleotide analogs on enzymes isolated from hepatitis C virus strains of various genotypes. Antimicrobial Agents and Chemotherapy. 52: 1901-11. PMID 18391043 DOI: 10.1128/Aac.01496-07  0.387
2006 Lam AM, Frick DN. Hepatitis C virus subgenomic replicon requires an active NS3 RNA helicase. Journal of Virology. 80: 404-11. PMID 16352565 DOI: 10.1128/Jvi.80.1.404-411.2006  0.373
2005 Sandhu AP, Lam AM, Fenske DB, Palmer LR, Johnston M, Cullis PR. Calcium enhances the transfection potency of stabilized plasmid-lipid particles. Analytical Biochemistry. 341: 156-64. PMID 15866540 DOI: 10.1016/J.Ab.2005.02.033  0.447
2004 Chen T, Palmer LR, Fenske DB, Lam AM, Wong KF, Cullis PR. Distal cationic poly(ethylene glycol) lipid conjugates in large unilamellar vesicles prepared by extrusion enhance liposomal cellular uptake. Journal of Liposome Research. 14: 155-73. PMID 15676124 DOI: 10.1081/Lpr-200033437  0.428
2003 Lam AM, Keeney D, Frick DN. Two novel conserved motifs in the hepatitis C virus NS3 protein critical for helicase action. The Journal of Biological Chemistry. 278: 44514-24. PMID 12944414 DOI: 10.1074/Jbc.M306444200  0.301
2003 Palmer LR, Chen T, Lam AM, Fenske DB, Wong KF, MacLachlan I, Cullis PR. Transfection properties of stabilized plasmid-lipid particles containing cationic PEG lipids. Biochimica Et Biophysica Acta. 1611: 204-16. PMID 12659962 DOI: 10.1016/S0005-2736(03)00058-0  0.452
2003 Lam AM, Keeney D, Eckert PQ, Frick DN. Hepatitis C virus NS3 ATPases/helicases from different genotypes exhibit variations in enzymatic properties. Journal of Virology. 77: 3950-61. PMID 12634355 DOI: 10.1128/Jvi.77.7.3950-3961.2003  0.311
2000 Lam AM, Cullis PR. Calcium enhances the transfection potency of plasmid DNA-cationic liposome complexes. Biochimica Et Biophysica Acta. 1463: 279-90. PMID 10675506 DOI: 10.1016/S0005-2736(99)00219-9  0.437
1999 Mok KW, Lam AM, Cullis PR. Stabilized plasmid-lipid particles: factors influencing plasmid entrapment and transfection properties. Biochimica Et Biophysica Acta. 1419: 137-50. PMID 10407066 DOI: 10.1016/S0005-2736(99)00059-0  0.408
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