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Aimin Xu, Ph.D. - Publications

Affiliations: 
2004 Louisiana State University, Baton Rouge, LA, United States 
Area:
Chemical Engineering, System Science Engineering
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Year Citation  Score
2005 Xu A, Indala S, Hertwig TA, Pike RW, Knopf FC, Yaws CL, Hopper JR. Development and integration of new processes consuming carbon dioxide in multi-plant chemical production complexes Clean Technologies and Environmental Policy. 7: 97-115. DOI: 10.1007/S10098-004-0270-Y  0.582
2002 Hertwig TA, Xu A, Nagy AB, Pike RW, Hopper JR, Yaws CL. A prototype system for economic, environmental and sustainable optimization of a chemical complex Clean Technologies and Environmental Policy. 3: 363-370. DOI: 10.1007/S10098-001-0132-9  0.582
Low-probability matches (unlikely to be authored by this person)
2006 Wang Y, Lam KS, Chan L, Chan KW, Lam JB, Lam MC, Hoo RC, Mak WW, Cooper GJ, Xu A. Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex. The Journal of Biological Chemistry. 281: 16391-400. PMID 16621799 DOI: 10.1074/jbc.M513907200  0.205
2009 Xu A, Wang H, Hoo RL, Sweeney G, Vanhoutte PM, Wang Y, Wu D, Chu W, Qin G, Lam KS. Selective elevation of adiponectin production by the natural compounds derived from a medicinal herb alleviates insulin resistance and glucose intolerance in obese mice. Endocrinology. 150: 625-33. PMID 18927219 DOI: 10.1210/En.2008-0999  0.201
2009 Hui X, Zhu W, Wang Y, Lam KS, Zhang J, Wu D, Kraegen EW, Li Y, Xu A. Major urinary protein-1 increases energy expenditure and improves glucose intolerance through enhancing mitochondrial function in skeletal muscle of diabetic mice. The Journal of Biological Chemistry. 284: 14050-7. PMID 19336396 DOI: 10.1074/Jbc.M109.001107  0.194
2021 Hallenborg P, Jensen BAH, Fjære E, Petersen RK, Belmaâti MS, Rasmussen SS, Gunnarsson JP, Lauritzen P, Cheng KKY, Hermansson M, Sonne SB, Ejsing CS, Xu A, Kratchmarova I, Krüger M, et al. Adipose MDM2 regulates systemic insulin sensitivity. Scientific Reports. 11: 21839. PMID 34750429 DOI: 10.1038/s41598-021-01240-3  0.192
2017 Nie B, Nie T, Hui X, Gu P, Mao L, Li K, Yuan R, Zheng J, Wang H, Li K, Tang S, Zhang Y, Xu T, Xu A, Wu D, et al. Brown Adipogenic Reprogramming Induced by a Small Molecule. Cell Reports. 18: 624-635. PMID 28099842 DOI: 10.1016/J.Celrep.2016.12.062  0.191
2015 Liu Y, Sen S, Wannaiampikul S, Palanivel R, Hoo RL, Isserlin R, Bader GD, Tungtrongchitr R, Deshaies Y, Xu A, Sweeney G. Metabolomic profiling in liver of adiponectin knockout mice uncovers lysophospholipid metabolism as an important target of adiponectin action. The Biochemical Journal. PMID 25915851 DOI: 10.1042/Bj20141455  0.19
2008 Hoo RL, Yeung DC, Lam KS, Xu A. Inflammatory biomarkers associated with obesity and insulin resistance: a focus on lipocalin-2 and adipocyte fatty acid-binding protein. Expert Review of Endocrinology & Metabolism. 3: 29-41. PMID 30743783 DOI: 10.1586/17446651.3.1.29  0.188
2021 Zhang Y, Cao H, Chen J, Li Y, Xu A, Wang Y. Adiponectin-expressing Treg facilitate T lymphocyte development in thymic nurse cell complexes. Communications Biology. 4: 344. PMID 33727658 DOI: 10.1038/s42003-021-01877-w  0.187
2009 Wang Y, Zhou M, Lam KS, Xu A. Protective roles of adiponectin in obesity-related fatty liver diseases: mechanisms and therapeutic implications. Arquivos Brasileiros De Endocrinologia E Metabologia. 53: 201-12. PMID 19466213 DOI: 10.1590/S0004-27302009000200012  0.186
2008 Wang Y, Lam KS, Yau MH, Xu A. Post-translational modifications of adiponectin: mechanisms and functional implications. The Biochemical Journal. 409: 623-33. PMID 18177270 DOI: 10.1042/BJ20071492  0.184
2013 Woo YC, Xu A, Wang Y, Lam KS. Fibroblast growth factor 21 as an emerging metabolic regulator: clinical perspectives. Clinical Endocrinology. 78: 489-96. PMID 23134073 DOI: 10.1111/cen.12095  0.181
2004 Wang Y, Lu G, Wong WP, Vliegenthart JF, Gerwig GJ, Lam KS, Cooper GJ, Xu A. Proteomic and functional characterization of endogenous adiponectin purified from fetal bovine serum. Proteomics. 4: 3933-42. PMID 15378692 DOI: 10.1002/pmic.200400826  0.179
2010 Hoo RL, Wong JY, Qiao C, Xu A, Xu H, Lam KS. The effective fraction isolated from Radix Astragali alleviates glucose intolerance, insulin resistance and hypertriglyceridemia in db/db diabetic mice through its anti-inflammatory activity. Nutrition & Metabolism. 7: 67. PMID 20735814 DOI: 10.1186/1743-7075-7-67  0.178
2022 Cao X, Shi T, Zhang C, Jin W, Song L, Zhang Y, Liu J, Yang F, Rotimi CN, Xu A, Yang J. ACE2 pathway regulates thermogenesis and energy metabolism. Elife. 11. PMID 35014608 DOI: 10.7554/eLife.72266  0.178
2016 Nie T, Hui X, Mao L, Nie B, Li K, Sun W, Gao X, Tang X, Xu Y, Jiang B, Tu Z, Li P, Ding K, Han W, Zhang S, ... Xu A, et al. Harmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis. Scientific Reports. 6: 36382. PMID 27805061 DOI: 10.1038/Srep36382  0.178
2003 Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. The Journal of Clinical Investigation. 112: 91-100. PMID 12840063 DOI: 10.1172/JCI17797  0.178
2015 Lee JT, Huang Z, Pan K, Zhang HJ, Woo CW, Xu A, Wong CM. Adipose-derived lipocalin 14 alleviates hyperglycaemia by suppressing both adipocyte glycerol efflux and hepatic gluconeogenesis in mice. Diabetologia. PMID 26592241 DOI: 10.1007/s00125-015-3813-3  0.177
2018 Cheang WS, Wong WT, Wang L, Cheng CK, Lau CW, Ma RCW, Xu A, Wang N, Huang Y, Tian XY. Resveratrol ameliorates endothelial dysfunction in diabetic and obese mice through sirtuin 1 and peroxisome proliferator-activated receptor δ. Pharmacological Research. 139: 384-394. PMID 30503839 DOI: 10.1016/j.phrs.2018.11.041  0.177
2006 Wang Y, Xu LY, Lam KS, Lu G, Cooper GJ, Xu A. Proteomic characterization of human serum proteins associated with the fat-derived hormone adiponectin. Proteomics. 6: 3862-70. PMID 16767790 DOI: 10.1002/pmic.200500840  0.177
2011 Gao X, Li K, Hui X, Kong X, Sweeney G, Wang Y, Xu A, Teng M, Liu P, Wu D. Carnitine palmitoyltransferase 1A prevents fatty acid-induced adipocyte dysfunction through suppression of c-Jun N-terminal kinase. The Biochemical Journal. 435: 723-32. PMID 21348853 DOI: 10.1042/Bj20101680  0.176
2022 Feng T, Zhao X, Gu P, Yang W, Wang C, Guo Q, Long Q, Liu Q, Cheng Y, Li J, Cheung CKY, Wu D, Kong X, Xu Y, Ye D, ... ... Xu A, et al. Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2. Nature Communications. 13: 5208. PMID 36064857 DOI: 10.1038/s41467-022-32871-3  0.176
2013 Hui E, Xu A, Bo Yang H, Lam KS. Obesity as the common soil of non-alcoholic fatty liver disease and diabetes: Role of adipokines. Journal of Diabetes Investigation. 4: 413-25. PMID 24843689 DOI: 10.1111/jdi.12093  0.176
2016 Jin L, Lin Z, Xu A. Fibroblast Growth Factor 21 Protects against Atherosclerosis via Fine-Tuning the Multiorgan Crosstalk. Diabetes & Metabolism Journal. 40: 22-31. PMID 26912152 DOI: 10.4093/dmj.2016.40.1.22  0.175
2007 Tso AW, Xu A, Sham PC, Wat NM, Wang Y, Fong CH, Cheung BM, Janus ED, Lam KS. Serum adipocyte fatty acid binding protein as a new biomarker predicting the development of type 2 diabetes: a 10-year prospective study in a Chinese cohort. Diabetes Care. 30: 2667-72. PMID 17620449 DOI: 10.2337/dc07-0413  0.174
2010 Richards AA, Colgrave ML, Zhang J, Webster J, Simpson F, Preston E, Wilks D, Hoehn KL, Stephenson M, Macdonald GA, Prins JB, Cooney GJ, Xu A, Whitehead JP. Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation. Molecular Endocrinology (Baltimore, Md.). 24: 229-39. PMID 19855092 DOI: 10.1210/me.2009-0133  0.173
2016 Wang Y, Cheng KK, Lam KS, Wu D, Wang Y, Huang Y, Vanhoutte PM, Sweeney G, Li Y, Xu A. Erratum. APPL1 Counteracts Obesity-Induced Vascular Insulin Resistance and Endothelial Dysfunction by Modulating the Endothelial Production of Nitric Oxide and Endothelin-1 in Mice. Diabetes 2011;60:3044-3054. Diabetes. 65: 3219. PMID 27659231 DOI: 10.2337/Db16-Er10C  0.171
2012 Ji Y, Sun S, Xu A, Bhargava P, Yang L, Lam KS, Gao B, Lee CH, Kersten S, Qi L. Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity. The Journal of Biological Chemistry. 287: 13561-71. PMID 22396530 DOI: 10.1074/Jbc.M112.350066  0.171
2013 Xu C, Bai B, Fan P, Cai Y, Huang B, Law IK, Liu L, Xu A, Tung C, Li X, Siu FM, Che CM, Vanhoutte PM, Wang Y. Selective overexpression of human SIRT1 in adipose tissue enhances energy homeostasis and prevents the deterioration of insulin sensitivity with ageing in mice. American Journal of Translational Research. 5: 412-26. PMID 23724165  0.17
2010 Chang J, Li Y, Huang Y, Lam KS, Hoo RL, Wong WT, Cheng KK, Wang Y, Vanhoutte PM, Xu A. Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway. Diabetes. 59: 2949-59. PMID 20802255 DOI: 10.2337/db10-0582  0.17
2016 Kwok KH, Lam KS, Xu A. Heterogeneity of white adipose tissue: molecular basis and clinical implications. Experimental & Molecular Medicine. 48: e215. PMID 26964831 DOI: 10.1038/emm.2016.5  0.169
2020 Geng L, Lam KSL, Xu A. The therapeutic potential of FGF21 in metabolic diseases: from bench to clinic. Nature Reviews. Endocrinology. PMID 32764725 DOI: 10.1038/s41574-020-0386-0  0.169
2021 Cheong LY, Xu A. Intercellular and inter-organ crosstalk in browning of white adipose tissue: molecular mechanism and therapeutic complications. Journal of Molecular Cell Biology. PMID 34185049 DOI: 10.1093/jmcb/mjab038  0.169
2009 Liu Y, Chewchuk S, Lavigne C, Brûlé S, Pilon G, Houde V, Xu A, Marette A, Sweeney G. Functional significance of skeletal muscle adiponectin production, changes in animal models of obesity and diabetes, and regulation by rosiglitazone treatment. American Journal of Physiology. Endocrinology and Metabolism. 297: E657-64. PMID 19531641 DOI: 10.1152/ajpendo.00186.2009  0.169
2011 Wong WT, Tian XY, Xu A, Yu J, Lau CW, Hoo RL, Wang Y, Lee VW, Lam KS, Vanhoutte PM, Huang Y. Adiponectin is required for PPARγ-mediated improvement of endothelial function in diabetic mice. Cell Metabolism. 14: 104-15. PMID 21723508 DOI: 10.1016/J.Cmet.2011.05.009  0.169
2018 Nie T, Zhao S, Mao L, Yang Y, Sun W, Lin X, Liu S, Li K, Sun Y, Li P, Zhou Z, Lin S, Hui X, Xu A, Ma CW, et al. A Natural Compound Formononetin Derived From Astragalus Membranaceus Increase Adipocyte Thermogenesis by Modulating PPARγ Activity. British Journal of Pharmacology. PMID 29315511 DOI: 10.1111/bph.14139  0.167
2008 Zhu W, Cheng KK, Vanhoutte PM, Lam KS, Xu A. Vascular effects of adiponectin: molecular mechanisms and potential therapeutic intervention. Clinical Science (London, England : 1979). 114: 361-74. PMID 18230060 DOI: 10.1042/CS20070347  0.167
2006 Chen B, Lam KS, Wang Y, Wu D, Lam MC, Shen J, Wong L, Hoo RL, Zhang J, Xu A. Hypoxia dysregulates the production of adiponectin and plasminogen activator inhibitor-1 independent of reactive oxygen species in adipocytes. Biochemical and Biophysical Research Communications. 341: 549-56. PMID 16427606 DOI: 10.1016/J.Bbrc.2006.01.004  0.166
2012 Hui X, Lam KS, Vanhoutte PM, Xu A. Adiponectin and cardiovascular health: an update. British Journal of Pharmacology. 165: 574-90. PMID 21457225 DOI: 10.1111/j.1476-5381.2011.01395.x  0.166
2021 Zhang J, Ni Y, Qian L, Fang Q, Zheng T, Zhang M, Gao Q, Zhang Y, Ni J, Hou X, Bao Y, Kovatcheva-Datchary P, Xu A, Li H, Panagiotou G, et al. Decreased Abundance of Akkermansia muciniphila Leads to the Impairment of Insulin Secretion and Glucose Homeostasis in Lean Type 2 Diabetes. Advanced Science (Weinheim, Baden-Wurttemberg, Germany). e2100536. PMID 34085773 DOI: 10.1002/advs.202100536  0.166
2024 Cui A, Xue Y, Su W, Lin J, Liu Y, Cai G, Wan Q, Jiang Y, Ding D, Zheng Z, Wei S, Li W, Shen J, Wen J, Huang M, ... ... Xu A, et al. Glucose regulation of adipose tissue browning by CBP/p300- and HDAC3-mediated reversible acetylation of CREBZF. Proceedings of the National Academy of Sciences of the United States of America. 121: e2318935121. PMID 38588421 DOI: 10.1073/pnas.2318935121  0.166
2016 Hui X, Feng T, Liu Q, Gao Y, Xu A. The FGF21-adiponectin axis in controlling energy and vascular homeostasis. Journal of Molecular Cell Biology. PMID 26993043 DOI: 10.1093/jmcb/mjw013  0.166
2013 Lin Z, Tian H, Lam KS, Lin S, Hoo RC, Konishi M, Itoh N, Wang Y, Bornstein SR, Xu A, Li X. Adiponectin mediates the metabolic effects of FGF21 on glucose homeostasis and insulin sensitivity in mice. Cell Metabolism. 17: 779-89. PMID 23663741 DOI: 10.1016/j.cmet.2013.04.005  0.165
2012 Tian XY, Wong WT, Xu A, Lu Y, Zhang Y, Wang L, Cheang WS, Wang Y, Yao X, Huang Y. Uncoupling protein-2 protects endothelial function in diet-induced obese mice. Circulation Research. 110: 1211-6. PMID 22461387 DOI: 10.1161/Circresaha.111.262170  0.165
2008 Liu L, Wang Y, Lam KS, Xu A. Moderate wine consumption in the prevention of metabolic syndrome and its related medical complications. Endocrine, Metabolic & Immune Disorders Drug Targets. 8: 89-98. PMID 18537695 DOI: 10.2174/187153008784534385  0.165
2023 Su X, Yy Cheung C, Zhong J, Ru Y, Hy Fong C, Lee CH, Liu Y, Ky Cheung C, Sl Lam K, Xu A, Cai Z. Ten metabolites-based algorithm predicts the future development of type 2 diabetes in Chinese. Journal of Advanced Research. PMID 38030128 DOI: 10.1016/j.jare.2023.11.026  0.164
2011 Xu A, Wang Y, Lam KS, Vanhoutte PM. Vascular actions of adipokines molecular mechanisms and therapeutic implications. Advances in Pharmacology (San Diego, Calif.). 60: 229-55. PMID 21081220 DOI: 10.1016/B978-0-12-385061-4.00008-8  0.164
2021 Huang Z, Xu A. Adipose Extracellular Vesicles in Intercellular and Inter-Organ Crosstalk in Metabolic Health and Diseases. Frontiers in Immunology. 12: 608680. PMID 33717092 DOI: 10.3389/fimmu.2021.608680  0.164
2006 Xu A, Wang Y, Xu JY, Stejskal D, Tam S, Zhang J, Wat NM, Wong WK, Lam KS. Adipocyte fatty acid-binding protein is a plasma biomarker closely associated with obesity and metabolic syndrome. Clinical Chemistry. 52: 405-13. PMID 16423904 DOI: 10.1373/clinchem.2005.062463  0.163
2008 Yeung DC, Wang Y, Xu A, Cheung SC, Wat NM, Fong DY, Fong CH, Chau MT, Sham PC, Lam KS. Epidermal fatty-acid-binding protein: a new circulating biomarker associated with cardio-metabolic risk factors and carotid atherosclerosis. European Heart Journal. 29: 2156-63. PMID 18603624 DOI: 10.1093/eurheartj/ehn295  0.162
2015 Nie T, Hui X, Gao X, Nie B, Mao L, Tang X, Yuan R, Li K, Li P, Xu A, Liu P, Ding S, Han W, Cooper GJ, Wu D. Conversion of non-adipogenic fibroblasts into adipocytes by a defined hormone mixture. The Biochemical Journal. 467: 487-94. PMID 25730278 DOI: 10.1042/Bj20140727  0.162
2010 Zhang X, Lam KS, Ye H, Chung SK, Zhou M, Wang Y, Xu A. Adipose tissue-specific inhibition of hypoxia-inducible factor 1{alpha} induces obesity and glucose intolerance by impeding energy expenditure in mice. The Journal of Biological Chemistry. 285: 32869-77. PMID 20716529 DOI: 10.1074/jbc.M110.135509  0.161
2022 Jin L, Yang R, Geng L, Xu A. Fibroblast Growth Factor-Based Pharmacotherapies for the Treatment of Obesity-Related Metabolic Complications. Annual Review of Pharmacology and Toxicology. PMID 36100222 DOI: 10.1146/annurev-pharmtox-032322-093904  0.161
2006 Lam KS, Xu A. Adiponectin: protection of the endothelium. Current Diabetes Reports. 5: 254-9. PMID 16033674 DOI: 10.1007/S11892-005-0019-Y  0.161
2017 Hui X, Zhang M, Gu P, Li K, Gao Y, Wu D, Wang Y, Xu A. Adipocyte SIRT1 controls systemic insulin sensitivity by modulating macrophages in adipose tissue. Embo Reports. PMID 28270525 DOI: 10.15252/embr.201643184  0.161
2021 Yang R, Hu Y, Lee CH, Liu Y, Diaz-Canestro C, Fong CHY, Lin H, Cheng KKY, Pravelil AP, Song E, Lam KS, Xu A. PM20D1 Is a Circulating Biomarker Closely Associated with Obesity, Insulin resistance and Metabolic Syndrome. European Journal of Endocrinology. PMID 34757919 DOI: 10.1530/EJE-21-0847  0.161
2010 Zhou M, Xu A, Lam KS, Tam PK, Che CM, Chan L, Lee IK, Wu D, Wang Y. Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin. Journal of Hepatology. 53: 1108-16. PMID 20828853 DOI: 10.1016/J.Jhep.2010.05.034  0.16
2015 Kim AY, Park YJ, Pan X, Shin KC, Kwak SH, Bassas AF, Sallam RM, Park KS, Alfadda AA, Xu A, Kim JB. Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance. Nature Communications. 6: 7585. PMID 26139044 DOI: 10.1038/Ncomms8585  0.16
2015 Lin Z, Pan X, Wu F, Ye D, Zhang Y, Wang Y, Jin L, Lian Q, Huang Y, Ding H, Triggle C, Wang K, Li X, Xu A. Fibroblast growth factor 21 prevents atherosclerosis by suppression of hepatic sterol regulatory element-binding protein-2 and induction of adiponectin in mice. Circulation. 131: 1861-71. PMID 25794851 DOI: 10.1161/Circulationaha.115.015308  0.159
2018 Xiao Y, Xiao X, Xu A, Chen X, Tang W, Zhou Z. Circulating adipocyte fatty acid-binding protein levels predict the development of subclinical atherosclerosis in type 2 diabetes. Journal of Diabetes and Its Complications. PMID 30314766 DOI: 10.1016/j.jdiacomp.2018.09.001  0.159
2007 Wang Y, Lam KS, Lam JB, Lam MC, Leung PT, Zhou M, Xu A. Overexpression of angiopoietin-like protein 4 alters mitochondria activities and modulates methionine metabolic cycle in the liver tissues of db/db diabetic mice. Molecular Endocrinology (Baltimore, Md.). 21: 972-86. PMID 17213385 DOI: 10.1210/me.2006-0249  0.159
2020 Liu Z, Wu KKL, Jiang X, Xu A, Cheng KKY. The role of adipose tissue senescence in obesity- and ageing-related metabolic disorders. Clinical Science (London, England : 1979). 134: 315-330. PMID 31998947 DOI: 10.1042/CS20190966  0.159
2011 Xu A, Vanhoutte PM. Adiponectin and adipocyte fatty acid binding protein in the pathogenesis of cardiovascular disease. American Journal of Physiology. Heart and Circulatory Physiology. 302: H1231-40. PMID 22210749 DOI: 10.1152/ajpheart.00765.2011  0.159
2017 Huang Z, Xu A, Cheung BM. The Potential Role of Fibroblast Growth Factor 21 in Lipid Metabolism and Hypertension. Current Hypertension Reports. 19: 28. PMID 28337713 DOI: 10.1007/s11906-017-0730-5  0.158
2005 Xu A, Lam MC, Chan KW, Wang Y, Zhang J, Hoo RL, Xu JY, Chen B, Chow WS, Tso AW, Lam KS. Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice. Proceedings of the National Academy of Sciences of the United States of America. 102: 6086-91. PMID 15837923 DOI: 10.1073/pnas.0408452102  0.157
2011 Zhang X, Xu A, Chung SK, Cresser JH, Sweeney G, Wong RL, Lin A, Lam KS. Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice. Diabetes. 60: 486-95. PMID 21270260 DOI: 10.2337/db10-0650  0.157
2017 Ye DW, Rong XL, Xu AM, Guo J. Liver-adipose tissue crosstalk: A key player in the pathogenesis of glucolipid metabolic disease. Chinese Journal of Integrative Medicine. 23: 410-414. PMID 28795382 DOI: 10.1007/s11655-017-2810-4  0.157
2013 Chow WS, Tso AW, Xu A, Yuen MM, Fong CH, Lam TH, Lo SV, Tse HF, Woo YC, Yeung CY, Cheung BM, Lam KS. Elevated circulating adipocyte-fatty acid binding protein levels predict incident cardiovascular events in a community-based cohort: a 12-year prospective study. Journal of the American Heart Association. 2: e004176. PMID 23525430 DOI: 10.1161/JAHA.112.004176  0.157
2009 Cheng KK, Iglesias MA, Lam KS, Wang Y, Sweeney G, Zhu W, Vanhoutte PM, Kraegen EW, Xu A. APPL1 potentiates insulin-mediated inhibition of hepatic glucose production and alleviates diabetes via Akt activation in mice. Cell Metabolism. 9: 417-27. PMID 19416712 DOI: 10.1016/j.cmet.2009.03.013  0.157
2018 Li H, Wu G, Fang Q, Zhang M, Hui X, Sheng B, Wu L, Bao Y, Li P, Xu A, Jia W. Fibroblast growth factor 21 increases insulin sensitivity through specific expansion of subcutaneous fat. Nature Communications. 9: 272. PMID 29348470 DOI: 10.1038/S41467-017-02677-9  0.156
2021 Xiao Y, Shu L, Wu X, Liu Y, Cheong LY, Liao B, Xiao X, Hoo RL, Zhou Z, Xu A. Fatty acid binding protein-4 promotes autoimmune diabetes by recruitment and activation of pancreatic islet macrophages. Jci Insight. PMID 33690220 DOI: 10.1172/jci.insight.141814  0.155
2016 Kwok KH, Cheng K, Hoo RL, Ye D, Xu A, Lam KS. Adipose-Specific Inactivation of JNK Alleviates Atherosclerosis in ApoE-deficient Mice. Clinical Science (London, England : 1979). PMID 27512097 DOI: 10.1042/CS20160465  0.155
2019 Wang F, Sun F, Luo J, Yue T, Chen L, Zhou H, Zhang J, Yang C, Luo X, Zhou Q, Zhu H, Li J, Yang P, Xiong F, Yu Q, ... ... Xu A, et al. Loss of ubiquitin-conjugating enzyme E2 (Ubc9) in macrophages exacerbates multiple low-dose streptozotocin-induced diabetes by attenuating M2 macrophage polarization. Cell Death & Disease. 10: 892. PMID 31767832 DOI: 10.1038/s41419-019-2130-z  0.155
2016 Jang H, Lee GY, Selby CP, Lee G, Jeon YG, Lee JH, Cheng KK, Titchenell P, Birnbaum MJ, Xu A, Sancar A, Kim JB. SREBP1c-CRY1 signalling represses hepatic glucose production by promoting FOXO1 degradation during refeeding. Nature Communications. 7: 12180. PMID 27412556 DOI: 10.1038/Ncomms12180  0.155
2012 Woo YC, Tso AW, Xu A, Law LS, Fong CH, Lam TH, Lo SV, Wat NM, Cheung BM, Lam KS. Combined use of serum adiponectin and tumor necrosis factor-alpha receptor 2 levels was comparable to 2-hour post-load glucose in diabetes prediction. Plos One. 7: e36868. PMID 22615828 DOI: 10.1371/journal.pone.0036868  0.154
2007 Xu A, Tso AW, Cheung BM, Wang Y, Wat NM, Fong CH, Yeung DC, Janus ED, Sham PC, Lam KS. Circulating adipocyte-fatty acid binding protein levels predict the development of the metabolic syndrome: a 5-year prospective study. Circulation. 115: 1537-43. PMID 17389279 DOI: 10.1161/CIRCULATIONAHA.106.647503  0.154
2012 Li FY, Lam KS, Tse HF, Chen C, Wang Y, Vanhoutte PM, Xu A. Endothelium-selective activation of AMP-activated protein kinase prevents diabetes mellitus-induced impairment in vascular function and reendothelialization via induction of heme oxygenase-1 in mice. Circulation. 126: 1267-77. PMID 22851545 DOI: 10.1161/CIRCULATIONAHA.112.108159  0.153
2016 Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Eugene Chin Y, Wang Y, Xiao H, ... ... Xu A, et al. Fibroblast Growth Factor 21 Improves Hepatic Insulin Sensitivity by Inhibiting Mammalian Target of Rapamycin Complex 1. Hepatology (Baltimore, Md.). PMID 26926384 DOI: 10.1002/hep.28523  0.153
2020 Shu L, Zhong L, Xiao Y, Wu X, Liu Y, Jiang X, Tang T, Hoo R, Zhou Z, Xu A. Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice. Clinical Science (London, England : 1979). 134: 1679-1696. PMID 32633320 DOI: 10.1042/CS20200021  0.153
2015 Liu Y, Palanivel R, Rai E, Park M, Gabor TV, Scheid MP, Xu A, Sweeney G. Adiponectin stimulates autophagy and reduces oxidative stress to enhance insulin sensitivity during high-fat diet feeding in mice. Diabetes. 64: 36-48. PMID 25071026 DOI: 10.2337/db14-0267  0.153
2011 Chen W, Hoo RL, Konishi M, Itoh N, Lee PC, Ye HY, Lam KS, Xu A. Growth hormone induces hepatic production of fibroblast growth factor 21 through a mechanism dependent on lipolysis in adipocytes. The Journal of Biological Chemistry. 286: 34559-66. PMID 21849508 DOI: 10.1074/jbc.M111.285965  0.153
2019 Zhao S, Chu Y, Zhang Y, Zhou Y, Jiang Z, Wang Z, Mao L, Li K, Sun W, Li P, Jia S, Wang C, Xu A, Loomes K, Tang S, et al. Linifanib exerts dual anti-obesity effect by regulating adipocyte browning and formation. Life Sciences. PMID 30708100 DOI: 10.1016/j.lfs.2019.01.047  0.152
2014 Wu G, Li H, Zhou M, Fang Q, Bao Y, Xu A, Jia W. Mechanism and clinical evidence of lipocalin-2 and adipocyte fatty acid-binding protein linking obesity and atherosclerosis. Diabetes/Metabolism Research and Reviews. 30: 447-56. PMID 24214285 DOI: 10.1002/dmrr.2493  0.152
2019 Geng L, Liao B, Jin L, Huang Z, Triggle CR, Ding H, Zhang J, Huang Y, Lin Z, Xu A. Exercise Alleviates Obesity-Induced Metabolic Dysfunction via Enhancing FGF21 Sensitivity in Adipose Tissues. Cell Reports. 26: 2738-2752.e4. PMID 30840894 DOI: 10.1016/J.Celrep.2019.02.014  0.15
2022 Xia W, Li X, Wu Q, Xu A, Zhang L, Xia Z. The importance of caveolin as a target in the prevention and treatment of diabetic cardiomyopathy. Frontiers in Immunology. 13: 951381. PMID 36405687 DOI: 10.3389/fimmu.2022.951381  0.15
2015 Xu C, Cai Y, Fan P, Bai B, Chen J, Deng HB, Che CM, Xu A, Vanhoutte PM, Wang Y. Calorie Restriction Prevents Metabolic Aging Caused by Abnormal SIRT1 Function in Adipose Tissues. Diabetes. 64: 1576-90. PMID 25475438 DOI: 10.2337/Db14-1180  0.15
2018 Zhang C, Chiu KY, Man Chan BP, Li T, Wen C, Xu A, Yan CH. Knocking out or Pharmaceutical Inhibition of Fatty Acid Binding Protein 4 (FABP4) Alleviates Osteoarthritis Induced by High-Fat Diet in Mice. Osteoarthritis and Cartilage. PMID 29549054 DOI: 10.1016/J.Joca.2018.03.002  0.15
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2009 Milner KL, van der Poorten D, Xu A, Bugianesi E, Kench JG, Lam KS, Chisholm DJ, George J. Adipocyte fatty acid binding protein levels relate to inflammation and fibrosis in nonalcoholic fatty liver disease. Hepatology (Baltimore, Md.). 49: 1926-34. PMID 19475694 DOI: 10.1002/hep.22896  0.149
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2022 Chen K, Cheong LY, Gao Y, Zhang Y, Feng T, Wang Q, Jin L, Honoré E, Lam KSL, Wang W, Hui X, Xu A. Adipose-targeted triiodothyronine therapy counteracts obesity-related metabolic complications and atherosclerosis with negligible side effects. Nature Communications. 13: 7838. PMID 36539421 DOI: 10.1038/s41467-022-35470-4  0.149
2023 Luo JY, Cheng CK, Gou L, He L, Zhao L, Zhang Y, Wang L, Lau CW, Xu A, Chen AF, Huang Y. Induction of KLF2 by exercise activates eNOS to improve vasodilatation in diabetic mice. Diabetes. PMID 37347764 DOI: 10.2337/db23-0070  0.149
2017 Chen DL, Brown R, Liess C, Poljak A, Xu A, Zhang J, Trenell M, Jenkins A, Chisholm D, Samocha-Bonet D, Macefield VG, Greenfield JR. Muscle Sympathetic Nerve Activity Is Associated with Liver Insulin Sensitivity in Obese Non-Diabetic Men. Frontiers in Physiology. 8: 101. PMID 28293196 DOI: 10.3389/fphys.2017.00101  0.149
2013 Ye H, Zhang HJ, Xu A, Hoo RL. Resistin production from adipose tissue is decreased in db/db obese mice, and is reversed by rosiglitazone. Plos One. 8: e65543. PMID 23776497 DOI: 10.1371/journal.pone.0065543  0.149
2014 Mao L, Lin W, Nie T, Hui X, Gao X, Li K, Ding M, Tang X, Li P, Wang Y, Xu A, Liu P, Wu D. Absence of Appl2 sensitizes endotoxin shock through activation of PI3K/Akt pathway. Cell & Bioscience. 4: 60. PMID 25328665 DOI: 10.1186/2045-3701-4-60  0.149
2007 Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A. Adiponectin-induced endothelial nitric oxide synthase activation and nitric oxide production are mediated by APPL1 in endothelial cells. Diabetes. 56: 1387-94. PMID 17287464 DOI: 10.2337/Db06-1580  0.149
2012 Nie T, Hui X, Gao X, Li K, Lin W, Xiang X, Ding M, Kuang Y, Xu A, Fei J, Wang Z, Wu D. Adipose tissue deletion of Gpr116 impairs insulin sensitivity through modulation of adipose function. Febs Letters. 586: 3618-25. PMID 22971422 DOI: 10.1016/J.Febslet.2012.08.006  0.148
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2012 Cheng KK, Lam KS, Wu D, Wang Y, Sweeney G, Hoo RL, Zhang J, Xu A. APPL1 potentiates insulin secretion in pancreatic β cells by enhancing protein kinase Akt-dependent expression of SNARE proteins in mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 8919-24. PMID 22566644 DOI: 10.1073/Pnas.1202435109  0.147
2005 Xu A, Chan KW, Hoo RL, Wang Y, Tan KC, Zhang J, Chen B, Lam MC, Tse C, Cooper GJ, Lam KS. Testosterone selectively reduces the high molecular weight form of adiponectin by inhibiting its secretion from adipocytes. The Journal of Biological Chemistry. 280: 18073-80. PMID 15760892 DOI: 10.1074/jbc.M414231200  0.147
2018 Zhang F, Hu Z, Li G, Huo S, Ma F, Cui A, Xue Y, Han Y, Gong Q, Gao J, Bian H, Meng Z, Wu H, Long G, Tan Y, ... ... Xu A, et al. Hepatic CREBZF Couples Insulin to Lipogenesis by Inhibiting Insig activity and Contributes to Hepatic Steatosis in Diet-Induced Insulin-Resistant Mice. Hepatology (Baltimore, Md.). PMID 29637572 DOI: 10.1002/hep.29926  0.147
2016 Li J, Lin S, Vanhoutte PM, Woo CW, Xu A. Akkermansia Muciniphila Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in Apoe-/- Mice. Circulation. PMID 27143680 DOI: 10.1161/CIRCULATIONAHA.115.019645  0.147
2016 Zhao Y, Gao P, Sun F, Li Q, Chen J, Yu H, Li L, Wei X, He H, Lu Z, Wei X, Wang B, Cui Y, Xiong S, Shang Q, ... Xu A, et al. Sodium Intake Regulates Glucose Homeostasis through the PPARδ/Adiponectin-Mediated SGLT2 Pathway. Cell Metabolism. PMID 27053360 DOI: 10.1016/j.cmet.2016.02.019  0.147
2008 Zhou M, Xu A, Tam PK, Lam KS, Chan L, Hoo RL, Liu J, Chow KH, Wang Y. Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury. Hepatology (Baltimore, Md.). 48: 1087-96. PMID 18698578 DOI: 10.1002/hep.22444  0.147
2011 Dehwah MA, Xu A, Huang Q. MicroRNAs and type 2 diabetes/obesity. Journal of Genetics and Genomics = Yi Chuan Xue Bao. 39: 11-8. PMID 22293113 DOI: 10.1016/j.jgg.2011.11.007  0.147
2020 Yan D, Cai Y, Luo J, Liu J, Li X, Ying F, Xie X, Xu A, Ma X, Xia Z. FOXO1 contributes to diabetic cardiomyopathy via inducing imbalanced oxidative metabolism in type 1 diabetes. Journal of Cellular and Molecular Medicine. PMID 32450616 DOI: 10.1111/Jcmm.15418  0.146
2015 Tang EH, Cai Y, Wong CK, Rocha VZ, Sukhova GK, Shimizu K, Xuan G, Vanhoutte PM, Libby P, Xu A. Activation of prostaglandin E2-EP4 signaling reduces chemokine production in adipose tissue. Journal of Lipid Research. 56: 358-68. PMID 25510249 DOI: 10.1194/jlr.M054817  0.146
2012 Tso AW, Xu A, Chow WS, Lam KS. Adipose tissue and the metabolic syndrome: focusing on adiponectin and several novel adipokines. Biomarkers in Medicine. 2: 239-52. PMID 20477413 DOI: 10.2217/17520363.2.3.239  0.146
2013 Cheng KK, Lam KS, Wang Y, Wu D, Zhang M, Wang B, Li X, Hoo RL, Huang Z, Sweeney G, Xu A. TRAF6-mediated ubiquitination of APPL1 enhances hepatic actions of insulin by promoting the membrane translocation of Akt. The Biochemical Journal. 455: 207-16. PMID 23909487 DOI: 10.1042/Bj20130760  0.146
2016 Vanhoutte PM, Zhao Y, Xu A, Leung SW. Thirty Years of Saying NO: Sources, Fate, Actions, and Misfortunes of the Endothelium-Derived Vasodilator Mediator. Circulation Research. 119: 375-96. PMID 27390338 DOI: 10.1161/CIRCRESAHA.116.306531  0.145
2018 Liu Z, Jin L, Yang JK, Wang B, Wu KK, Hallenborg P, Xu A, Cheng KK. The Dysfunctional MDM2-p53 Axis in Adipocytes Contributes to Ageing Related Metabolic Complications by Induction of Lipodystrophy. Diabetes. PMID 30131393 DOI: 10.2337/db18-0684  0.145
2004 Xu A, Wong LC, Wang Y, Xu JY, Cooper GJ, Lam KS. Chronic treatment with growth hormone stimulates adiponectin gene expression in 3T3-L1 adipocytes. Febs Letters. 572: 129-34. PMID 15304336 DOI: 10.1016/j.febslet.2004.07.020  0.145
2021 Li HL, Wu X, Xu A, Hoo RL. A-FABP in Metabolic Diseases and the Therapeutic Implications: An Update. International Journal of Molecular Sciences. 22. PMID 34502295 DOI: 10.3390/ijms22179386  0.144
2015 Chan SM, Zeng XY, Sun RQ, Jo E, Zhou X, Wang H, Li S, Xu A, Watt MJ, Ye JM. Fenofibrate insulates diacylglycerol in lipid droplet/ER and preserves insulin signaling transduction in the liver of high fat fed mice. Biochimica Et Biophysica Acta. 1852: 1511-9. PMID 25906681 DOI: 10.1016/j.bbadis.2015.04.005  0.144
2010 Chen C, Tso AWK, Law LSC, Cheung BMY, Ong KL, Wat NMS, Janus ED, Xu A, Lam KSL. Plasma level of pigment epithelium-derived factor is independently associated with the development of the metabolic syndrome in chinese men: A 10-year prospective study Journal of Clinical Endocrinology and Metabolism. 95: 5074-5081. PMID 20685859 DOI: 10.1210/jc.2010-0727  0.144
2014 Cheng KK, Lam KS, Wang B, Xu A. Signaling mechanisms underlying the insulin-sensitizing effects of adiponectin. Best Practice & Research. Clinical Endocrinology & Metabolism. 28: 3-13. PMID 24417941 DOI: 10.1016/j.beem.2013.06.006  0.144
2011 Ge X, Chen C, Hui X, Wang Y, Lam KS, Xu A. Fibroblast growth factor 21 induces glucose transporter-1 expression through activation of the serum response factor/Ets-like protein-1 in adipocytes. The Journal of Biological Chemistry. 286: 34533-41. PMID 21846717 DOI: 10.1074/jbc.M111.248591  0.143
2013 Cao M, Mao Z, Kam C, Xiao N, Cao X, Shen C, Cheng KK, Xu A, Lee KM, Jiang L, Xia J. PICK1 and ICA69 control insulin granule trafficking and their deficiencies lead to impaired glucose tolerance. Plos Biology. 11: e1001541. PMID 23630453 DOI: 10.1371/Journal.Pbio.1001541  0.143
2023 Lee CH, Lui DT, Li RH, Yuen MM, Fong CH, Leung AP, Chu JC, Mak LL, Lam TH, Woo J, Woo YC, Xu A, Tse HF, Tan KC, Cheung BM, et al. Sequential algorithm to stratify liver fibrosis risk in overweight/obese metabolic dysfunction-associated fatty liver disease. Frontiers in Endocrinology. 13: 1056562. PMID 36686469 DOI: 10.3389/fendo.2022.1056562  0.143
2019 Li D, Sun WY, Fu B, Xu A, Wang Y. Lipocalin-2 - the myth of its expression and function. Basic & Clinical Pharmacology & Toxicology. PMID 31597008 DOI: 10.1111/bcpt.13332  0.143
2018 Baretella O, Xu A, Vanhoutte PM. No Protective Effect of Constitutive Activation of AMPK in Endothelial Cells on Vascular Function in Aged Obese Mice but Augmented α1-Adrenergic Contractions in Renal Arteries Reversible by Weight Loss. Journal of Vascular Research. 55: 189-202. PMID 29996143 DOI: 10.1159/000489959  0.143
2022 Zhong J, Cheung CYY, Su X, Lee CH, Ru Y, Fong CHY, Liu Y, Cheung CKY, Lam KSL, Cai Z, Xu A. Specific triacylglycerol, diacylglycerol, and lyso-phosphatidylcholine species for the prediction of type 2 diabetes: a ~ 16-year prospective study in Chinese. Cardiovascular Diabetology. 21: 234. PMID 36335348 DOI: 10.1186/s12933-022-01677-4  0.142
2020 Liu J, Xie X, Yan D, Wang Y, Yuan H, Cai Y, Luo J, Xu A, Huang Y, Cheung CW, Irwin MG, Xia Z. Up-regulation of FoxO1 contributes to adverse vascular remodelling in type 1 diabetic rats. Journal of Cellular and Molecular Medicine. PMID 33108705 DOI: 10.1111/jcmm.15935  0.142
2016 Kopprasch S, Dheban S, Schuhmann K, Xu A, Schulte KM, Simeonovic CJ, Schwarz PE, Bornstein SR, Shevchenko A, Graessler J. Detection of Independent Associations of Plasma Lipidomic Parameters with Insulin Sensitivity Indices Using Data Mining Methodology. Plos One. 11: e0164173. PMID 27736893 DOI: 10.1371/journal.pone.0164173  0.142
2017 Yang K, Deng HB, Man AWC, Song E, Zhang J, Luo C, Cheung BMY, Yuen KY, Jensen PS, Irmukhamedov A, Elie AGIM, Vanhoutte PM, Xu A, De Mey JGR, Wang Y. Measuring non-polyaminated lipocalin-2 for cardiometabolic risk assessment. Esc Heart Failure. 4: 563-575. PMID 29154418 DOI: 10.1002/ehf2.12183  0.141
2017 Shu L, Hoo RL, Wu X, Pan Y, Lee IP, Cheong LY, Bornstein SR, Rong X, Guo J, Xu A. A-FABP mediates adaptive thermogenesis by promoting intracellular activation of thyroid hormones in brown adipocytes. Nature Communications. 8: 14147. PMID 28128199 DOI: 10.1038/ncomms14147  0.141
2002 Xu A, Choi KL, Wang Y, Permana PA, Xu LY, Bogardus C, Cooper GJ. Identification of novel putative membrane proteins selectively expressed during adipose conversion of 3T3-L1 cells. Biochemical and Biophysical Research Communications. 293: 1161-7. PMID 12054497 DOI: 10.1016/S0006-291X(02)00354-6  0.141
2021 Wu KKL, Long K, Lin H, Siu PMF, Hoo RLC, Ye D, Xu A, Cheng KKY. The APPL1-Rab5 axis restricts NLRP3 inflammasome activation through early endosomal-dependent mitophagy in macrophages. Nature Communications. 12: 6637. PMID 34789781 DOI: 10.1038/s41467-021-26987-1  0.141
2010 Law IK, Xu A, Lam KS, Berger T, Mak TW, Vanhoutte PM, Liu JT, Sweeney G, Zhou M, Yang B, Wang Y. Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity. Diabetes. 59: 872-82. PMID 20068130 DOI: 10.2337/db09-1541  0.141
2013 Li H, Hui X, Yang S, Hu X, Tang X, Li P, Li S, Yang L, Jin S, Wang Y, Xu A, Wu D. High level expression, efficient purification and bioactivity assay of recombinant human platelet-derived growth factor AA dimer (PDGF-AA) from methylotrophic yeast Pichia pastoris. Protein Expression and Purification. 91: 221-7. PMID 23978536 DOI: 10.1016/J.Pep.2013.08.008  0.141
2022 Zhang P, Konja D, Zhang Y, Xu A, Lee IK, Jeon JH, Bashiri G, Mitra A, Wang Y. Clusterin is involved in mediating the metabolic function of adipose SIRT1. Iscience. 25: 103709. PMID 35072003 DOI: 10.1016/j.isci.2021.103709  0.141
2014 Lamounier-Zepter V, Look C, Schunck WH, Schlottmann I, Woischwill C, Bornstein SR, Xu A, Morano I. Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility. International Journal of Obesity (2005). 39: 755-61. PMID 25370574 DOI: 10.1038/ijo.2014.193  0.141
2013 Kai AK, Lam AK, Chen Y, Tai AC, Zhang X, Lai AK, Yeung PK, Tam S, Wang J, Lam KS, Vanhoutte PM, Bos JL, Chung SS, Xu A, Chung SK. Exchange protein activated by cAMP 1 (Epac1)-deficient mice develop β-cell dysfunction and metabolic syndrome. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 4122-35. PMID 23825225 DOI: 10.1096/fj.13-230433  0.14
2023 Gan J, Shi Y, Zhao R, Li D, Jin H, Wu M, Liu Z, Li X, Xu A, Li Y, Lin Z, Wu F. Adipose c-Jun NH2-terminal kinase promotes angiotensin II-induced and deoxycorticosterone acetate salt-induced hypertension and vascular dysfunction by inhibition of adiponectin production and activation of SGK1 in mice. Journal of Hypertension. PMID 38164960 DOI: 10.1097/HJH.0000000000003649  0.14
2007 Wang Y, Lam KS, Kraegen EW, Sweeney G, Zhang J, Tso AW, Chow WS, Wat NM, Xu JY, Hoo RL, Xu A. Lipocalin-2 is an inflammatory marker closely associated with obesity, insulin resistance, and hyperglycemia in humans. Clinical Chemistry. 53: 34-41. PMID 17040956 DOI: 10.1373/clinchem.2006.075614  0.14
2011 Ong KL, Tso AWK, Xu A, Law LSC, Li M, Wat NMS, Rye KA, Lam TH, Cheung BMY, Lam KSL. Evaluation of the combined use of adiponectin and C-reactive protein levels as biomarkers for predicting the deterioration in glycaemia after a median of 5.4 years Diabetologia. 54: 2552-2560. PMID 21727999 DOI: 10.1007/s00125-011-2227-0  0.14
2011 Chen C, Cheung BM, Tso AW, Wang Y, Law LS, Ong KL, Wat NM, Xu A, Lam KS. High plasma level of fibroblast growth factor 21 is an Independent predictor of type 2 diabetes: a 5.4-year population-based prospective study in Chinese subjects. Diabetes Care. 34: 2113-5. PMID 21750278 DOI: 10.2337/dc11-0294  0.14
2017 Chen J, Li J, Yiu JHC, Lam JKW, Wong CM, Dorweiler B, Xu A, Woo CW. TRIF-dependent Toll-like receptor signaling suppresses Scd1 transcription in hepatocytes and prevents diet-induced hepatic steatosis. Science Signaling. 10. PMID 28790196 DOI: 10.1126/scisignal.aal3336  0.14
2020 Ong KL, Wu L, Januszewski AS, O'Connell RL, Xu A, Rye KA, Ma RCW, Li H, Jenkins AJ, Jia W, Keech AC. Relationships of adipocyte-fatty acid binding protein and lipocalin 2 with risk factors and chronic complications in type 2 diabetes and effects of fenofibrate: a Fenofibrate Intervention and Event Lowering in Diabetes Sub-study. Diabetes Research and Clinical Practice. 108450. PMID 32949655 DOI: 10.1016/j.diabres.2020.108450  0.14
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2011 Wang Y, Cheng KK, Lam KS, Wu D, Wang Y, Huang Y, Vanhoutte PM, Sweeney G, Li Y, Xu A. APPL1 counteracts obesity-induced vascular insulin resistance and endothelial dysfunction by modulating the endothelial production of nitric oxide and endothelin-1 in mice. Diabetes. 60: 3044-54. PMID 21926268 DOI: 10.2337/Db11-0666  0.139
2015 So WY, Cheng Q, Xu A, Lam KS, Leung PS. Loss of fibroblast growth factor 21 action induces insulin resistance, pancreatic islet hyperplasia and dysfunction in mice. Cell Death & Disease. 6: e1707. PMID 25811804 DOI: 10.1038/Cddis.2015.80  0.139
2013 Gu P, Xu A. Interplay between adipose tissue and blood vessels in obesity and vascular dysfunction. Reviews in Endocrine & Metabolic Disorders. 14: 49-58. PMID 23283583 DOI: 10.1007/s11154-012-9230-8  0.139
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2003 Xu A, Yin S, Wong L, Chan KW, Lam KS. Adiponectin ameliorates dyslipidemia induced by the human immunodeficiency virus protease inhibitor ritonavir in mice. Endocrinology. 145: 487-94. PMID 14592951 DOI: 10.1210/EN.2003-1140  0.139
2010 Wong WT, Tian XY, Xu A, Ng CF, Lee HK, Chen ZY, Au CL, Yao X, Huang Y. Angiotensin II type 1 receptor-dependent oxidative stress mediates endothelial dysfunction in type 2 diabetic mice. Antioxidants & Redox Signaling. 13: 757-68. PMID 20136508 DOI: 10.1089/Ars.2009.2831  0.138
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2009 Wang Y, Huang Y, Lam KS, Li Y, Wong WT, Ye H, Lau CW, Vanhoutte PM, Xu A. Berberine prevents hyperglycemia-induced endothelial injury and enhances vasodilatation via adenosine monophosphate-activated protein kinase and endothelial nitric oxide synthase. Cardiovascular Research. 82: 484-92. PMID 19251722 DOI: 10.1093/cvr/cvp078  0.138
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2013 Liu Y, Turdi S, Park T, Morris NJ, Deshaies Y, Xu A, Sweeney G. Adiponectin corrects high-fat diet-induced disturbances in muscle metabolomic profile and whole-body glucose homeostasis. Diabetes. 62: 743-52. PMID 23238294 DOI: 10.2337/Db12-0687  0.137
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2008 Zhang X, Yeung DC, Karpisek M, Stejskal D, Zhou ZG, Liu F, Wong RL, Chow WS, Tso AW, Lam KS, Xu A. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes. 57: 1246-53. PMID 18252893 DOI: 10.2337/db07-1476  0.136
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2010 Fang X, Palanivel R, Cresser J, Schram K, Ganguly R, Thong FS, Tuinei J, Xu A, Abel ED, Sweeney G. An APPL1-AMPK signaling axis mediates beneficial metabolic effects of adiponectin in the heart. American Journal of Physiology. Endocrinology and Metabolism. 299: E721-9. PMID 20739511 DOI: 10.1152/ajpendo.00086.2010  0.136
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2013 Yang S, Kuang Y, Li H, Liu Y, Hui X, Li P, Jiang Z, Zhou Y, Wang Y, Xu A, Li S, Liu P, Wu D. Enhanced production of recombinant secretory proteins in Pichia pastoris by optimizing Kex2 P1' site. Plos One. 8: e75347. PMID 24069404 DOI: 10.1371/Journal.Pone.0075347  0.136
2015 Zhou M, Bao Y, Li H, Pan Y, Shu L, Xia Z, Wu D, Lam KS, Vanhoutte PM, Xu A, Jia W, Hoo RL. Deficiency of adipocyte fatty-acid-binding protein alleviates myocardial ischaemia/reperfusion injury and diabetes-induced cardiac dysfunction. Clinical Science (London, England : 1979). 129: 547-59. PMID 26186740 DOI: 10.1042/Cs20150073  0.136
2017 Zhu C, Zhang W, Mu B, Zhang F, Lai N, Zhou J, Xu A, Liu J, Li Y. Effects of marine collagen peptides on glucose metabolism and insulin resistance in type 2 diabetic rats. Journal of Food Science and Technology. 54: 2260-2269. PMID 28740282 DOI: 10.1007/s13197-017-2663-z  0.135
2017 Hoo RL, Shu L, Cheng KK, Wu X, Liao B, Wu D, Zhou Z, Xu A. Adipocyte Fatty Acid Binding Protein Potentiates Toxic Lipids-Induced Endoplasmic Reticulum Stress in Macrophages via Inhibition of Janus Kinase 2-dependent Autophagy. Scientific Reports. 7: 40657. PMID 28094778 DOI: 10.1038/Srep40657  0.135
2023 Lee CH, Lui DT, Cheung CY, Fong CH, Yuen MM, Woo YC, Chow WS, Wong IY, Xu A, Lam KS. Circulating AFABP, FGF21 and PEDF levels as prognostic biomarkers of sight-threatening diabetic retinopathy. The Journal of Clinical Endocrinology and Metabolism. PMID 36856742 DOI: 10.1210/clinem/dgad112  0.135
2015 Ramezani-Moghadam M, Wang J, Ho V, Iseli TJ, Alzahrani B, Xu A, Van der Poorten D, Qiao L, George J, Hebbard L. Adiponectin reduces hepatic stellate cell migration by promoting tissue inhibitor of metalloproteinase-1 (TIMP-1) secretion. The Journal of Biological Chemistry. 290: 5533-42. PMID 25575598 DOI: 10.1074/jbc.M114.598011  0.135
2014 Xiao J, Xing F, Huo J, Fung ML, Liong EC, Ching YP, Xu A, Chang RC, So KF, Tipoe GL. Lycium barbarum polysaccharides therapeutically improve hepatic functions in non-alcoholic steatohepatitis rats and cellular steatosis model. Scientific Reports. 4: 5587. PMID 24998389 DOI: 10.1038/srep05587  0.135
2012 Li H, Gao Z, Zhang J, Ye X, Xu A, Ye J, Jia W. Sodium butyrate stimulates expression of fibroblast growth factor 21 in liver by inhibition of histone deacetylase 3. Diabetes. 61: 797-806. PMID 22338096 DOI: 10.2337/db11-0846  0.135
2011 Yu H, Xia F, Lam KS, Wang Y, Bao Y, Zhang J, Gu Y, Zhou P, Lu J, Jia W, Xu A. Circadian rhythm of circulating fibroblast growth factor 21 is related to diurnal changes in fatty acids in humans. Clinical Chemistry. 57: 691-700. PMID 21325103 DOI: 10.1373/clinchem.2010.155184  0.135
2013 So WY, Cheng Q, Chen L, Evans-Molina C, Xu A, Lam KS, Leung PS. High glucose represses β-klotho expression and impairs fibroblast growth factor 21 action in mouse pancreatic islets: involvement of peroxisome proliferator-activated receptor γ signaling. Diabetes. 62: 3751-9. PMID 23897951 DOI: 10.2337/Db13-0645  0.135
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2009 Lam JB, Chow KH, Xu A, Lam KS, Liu J, Wong NS, Moon RT, Shepherd PR, Cooper GJ, Wang Y. Adiponectin haploinsufficiency promotes mammary tumor development in MMTV-PyVT mice by modulation of phosphatase and tensin homolog activities. Plos One. 4: e4968. PMID 19319191 DOI: 10.1371/journal.pone.0004968  0.13
2015 Hui X, Gu P, Zhang J, Nie T, Pan Y, Wu D, Feng T, Zhong C, Wang Y, Lam KS, Xu A. Adiponectin Enhances Cold-Induced Browning of Subcutaneous Adipose Tissue via Promoting M2 Macrophage Proliferation. Cell Metabolism. PMID 26166748 DOI: 10.1016/J.Cmet.2015.06.004  0.13
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2018 Li H, Xiao Y, Tang L, Zhong F, Huang G, Xu JM, Xu AM, Dai RP, Zhou ZG. Adipocyte Fatty Acid-Binding Protein Promotes Palmitate-Induced Mitochondrial Dysfunction and Apoptosis in Macrophages. Frontiers in Immunology. 9: 81. PMID 29441065 DOI: 10.3389/fimmu.2018.00081  0.129
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2014 Wang Y, Xiao Y, Zhong L, Ye D, Zhang J, Tu Y, Bornstein SR, Zhou Z, Lam KS, Xu A. Increased neutrophil elastase and proteinase 3 and augmented NETosis are closely associated with β-cell autoimmunity in patients with type 1 diabetes. Diabetes. 63: 4239-48. PMID 25092677 DOI: 10.2337/db14-0480  0.129
2016 Ng RC, Cheng OY, Jian M, Kwan JS, Ho PW, Cheng KK, Yeung PK, Zhou LL, Hoo RL, Chung SK, Xu A, Lam KS, Chan KH. Chronic adiponectin deficiency leads to Alzheimer's disease-like cognitive impairments and pathologies through AMPK inactivation and cerebral insulin resistance in aged mice. Molecular Neurodegeneration. 11: 71. PMID 27884163 DOI: 10.1186/s13024-016-0136-x  0.129
2013 Hoo RL, Lee IP, Zhou M, Wong JY, Hui X, Xu A, Lam KS. Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice. Journal of Hepatology. 58: 358-64. PMID 23108115 DOI: 10.1016/j.jhep.2012.10.022  0.129
2013 Heilbronn LK, Campbell LV, Xu A, Samocha-Bonet D. Metabolically protective cytokines adiponectin and fibroblast growth factor-21 are increased by acute overfeeding in healthy humans. Plos One. 8: e78864. PMID 24205333 DOI: 10.1371/journal.pone.0078864  0.128
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2013 Xiao Y, Xu A, Hui X, Zhou P, Li X, Zhong H, Tang W, Huang G, Zhou Z. Circulating lipocalin-2 and retinol-binding protein 4 are associated with intima-media thickness and subclinical atherosclerosis in patients with type 2 diabetes. Plos One. 8: e66607. PMID 23799122 DOI: 10.1371/journal.pone.0066607  0.128
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2014 Li H, Hui X, Li K, Tang X, Hu X, Xu A, Wu D. High-level expression, purification and characterization of active human C1q and tumour necrosis factor-related protein-1 in Escherichia coli. Letters in Applied Microbiology. 59: 334-341. PMID 24814641 DOI: 10.1111/Lam.12280  0.127
2017 Zhu C, Zhang W, Liu J, Mu B, Zhang F, Lai N, Zhou J, Xu A, Li Y. Marine collagen peptides reduce endothelial cell injury in diabetic rats by inhibiting apoptosis and the expression of coupling factor 6 and microparticles. Molecular Medicine Reports. PMID 28731155 DOI: 10.3892/mmr.2017.7061  0.127
2013 Xiao J, Liong EC, Ching YP, Chang RC, Fung ML, Xu AM, So KF, Tipoe GL. Lycium barbarum polysaccharides protect rat liver from non-alcoholic steatohepatitis-induced injury. Nutrition & Diabetes. 3: e81. PMID 23877747 DOI: 10.1038/nutd.2013.22  0.127
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2014 Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, van den Berg S, van den Berg S, Soehnlein O, Winkels H, Beckers L, Lievens D, Driessen A, Kusters P, Biessen E, Garcia-Martin R, ... ... Xu A, et al. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance. Proceedings of the National Academy of Sciences of the United States of America. 111: 2686-91. PMID 24492375 DOI: 10.1073/Pnas.1400419111  0.127
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2015 Li S, Zeng XY, Zhou X, Wang H, Jo E, Robinson SR, Xu A, Ye JM. Dietary cholesterol induces hepatic inflammation and blunts mitochondrial function in the liver of high-fat-fed mice. The Journal of Nutritional Biochemistry. PMID 26391864 DOI: 10.1016/J.Jnutbio.2015.08.021  0.125
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2010 Hui X, Li H, Zhou Z, Lam KS, Xiao Y, Wu D, Ding K, Wang Y, Vanhoutte PM, Xu A. Adipocyte fatty acid-binding protein modulates inflammatory responses in macrophages through a positive feedback loop involving c-Jun NH2-terminal kinases and activator protein-1. The Journal of Biological Chemistry. 285: 10273-80. PMID 20145251 DOI: 10.1074/Jbc.M109.097907  0.125
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2012 Xiao Y, Xu A, Law LS, Chen C, Li H, Li X, Yang L, Liu S, Zhou Z, Lam KS. Distinct changes in serum fibroblast growth factor 21 levels in different subtypes of diabetes. The Journal of Clinical Endocrinology and Metabolism. 97: E54-8. PMID 22013098 DOI: 10.1210/jc.2011-1930  0.125
2014 Song E, Fan P, Huang B, Deng HB, Cheung BM, Félétou M, Vilaine JP, Villeneuve N, Xu A, Vanhoutte PM, Wang Y. Deamidated lipocalin-2 induces endothelial dysfunction and hypertension in dietary obese mice. Journal of the American Heart Association. 3: e000837. PMID 24721803 DOI: 10.1161/JAHA.114.000837  0.124
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2016 Li X, Cheng KK, Liu Z, Yang JK, Wang B, Jiang X, Zhou Y, Hallenborg P, Hoo RL, Lam KS, Ikeda Y, Gao X, Xu A. The MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells. Nature Communications. 7: 11740. PMID 27265727 DOI: 10.1038/ncomms11740  0.124
2016 Cheng KK, Lam KS, Wang Y, Huang Y, Carling D, Wu D, Wong C, Xu A. Erratum. Adiponectin-Induced Endothelial Nitric Oxide Synthase Activation and Nitric Oxide Production Are Mediated by APPL1 in Endothelial Cells. Diabetes 2007;56:1387-1394. Diabetes. 65: 3218. PMID 27659229 DOI: 10.2337/Db16-Er10A  0.123
2019 Bai B, Yang W, Fu Y, Foon HL, Tay WT, Yang K, Luo C, Gunaratne J, Lee P, Zile MR, Xu A, Chin CWL, Lam CSP, Han W, Wang Y. Seipin Knockout Mice Develop Heart Failure With Preserved Ejection Fraction. Jacc. Basic to Translational Science. 4: 924-937. PMID 31909301 DOI: 10.1016/J.Jacbts.2019.07.008  0.123
2016 San Cheang W, Wong WT, Zhao L, Xu J, Wang L, Lau CW, Chen ZY, Wan Ma RC, Xu A, Wang N, Tian XY, Huang Y. PPARδ Is Required for Exercise to Attenuate Endoplasmic Reticulum Stress and Endothelial Dysfunction in Diabetic Mice. Diabetes. PMID 27856609 DOI: 10.2337/db15-1657  0.123
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2011 Wang T, Qiao S, Lei S, Liu Y, Ng KF, Xu A, Lam KS, Irwin MG, Xia Z. N-acetylcysteine and allopurinol synergistically enhance cardiac adiponectin content and reduce myocardial reperfusion injury in diabetic rats. Plos One. 6: e23967. PMID 21912612 DOI: 10.1371/Journal.Pone.0023967  0.123
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2013 Yeung CY, Tso AW, Xu A, Wang Y, Woo YC, Lam TH, Lo SV, Fong CH, Wat NM, Woo J, Cheung BM, Lam KS. Pro-inflammatory adipokines as predictors of incident cancers in a Chinese cohort of low obesity prevalence in Hong Kong. Plos One. 8: e78594. PMID 24205276 DOI: 10.1371/Journal.Pone.0078594  0.121
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2014 Palanivel R, Ganguly R, Turdi S, Xu A, Sweeney G. Adiponectin stimulates Rho-mediated actin cytoskeleton remodeling and glucose uptake via APPL1 in primary cardiomyocytes. Metabolism: Clinical and Experimental. 63: 1363-73. PMID 25108566 DOI: 10.1016/j.metabol.2014.07.005  0.121
2009 Zhou Y, Wang D, Zhu Q, Gao X, Yang S, Xu A, Wu D. Inhibitory effects of A-769662, a novel activator of AMP-activated protein kinase, on 3T3-L1 adipogenesis. Biological & Pharmaceutical Bulletin. 32: 993-8. PMID 19483304 DOI: 10.1248/Bpb.32.993  0.121
2013 Chow WS, Xu A, Woo YC, Tso AW, Cheung SC, Fong CH, Tse HF, Chau MT, Cheung BM, Lam KS. Serum fibroblast growth factor-21 levels are associated with carotid atherosclerosis independent of established cardiovascular risk factors. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 2454-9. PMID 23887638 DOI: 10.1161/ATVBAHA.113.301599  0.12
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2019 Liu Y, Wang Y, Ni Y, Cheung CKY, Lam KSL, Wang Y, Xia Z, Ye D, Guo J, Tse MA, Panagiotou G, Xu A. Gut Microbiome Fermentation Determines the Efficacy of Exercise for Diabetes Prevention. Cell Metabolism. PMID 31786155 DOI: 10.1016/J.Cmet.2019.11.001  0.12
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2018 Li H, Luo HY, Liu Q, Xiao Y, Tang L, Zhong F, Huang G, Xu JM, Xu AM, Zhou ZG, Dai RP. Intermittent High Glucose Exacerbates A-FABP Activation and Inflammatory Response through TLR4-JNK Signaling in THP-1 Cells. Journal of Immunology Research. 2018: 1319272. PMID 29850615 DOI: 10.1155/2018/1319272  0.12
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2014 Ye D, Wang Y, Li H, Jia W, Man K, Lo CM, Wang Y, Lam KS, Xu A. Fibroblast growth factor 21 protects against acetaminophen-induced hepatotoxicity by potentiating peroxisome proliferator-activated receptor coactivator protein-1α-mediated antioxidant capacity in mice. Hepatology (Baltimore, Md.). 60: 977-89. PMID 24590984 DOI: 10.1002/hep.27060  0.119
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2014 Wong CM, Wang Y, Lee JT, Huang Z, Wu D, Xu A, Lam KS. Adropin is a brain membrane-bound protein regulating physical activity via the NB-3/Notch signaling pathway in mice. The Journal of Biological Chemistry. 289: 25976-86. PMID 25074942 DOI: 10.1074/Jbc.M114.576058  0.119
2019 Konja D, Luo C, Sun WY, Yang K, Man AWC, Xu A, Vanhoutte PM, Wang Y. Assessment of Vascular Tone Responsiveness using Isolated Mesenteric Arteries with a Focus on Modulation by Perivascular Adipose Tissues. Journal of Visualized Experiments : Jove. PMID 31205306 DOI: 10.3791/59688  0.119
2015 Li H, Yao W, Liu Z, Xu A, Huang Y, Ma XL, Irwin MG, Xia Z. Hyperglycemia Abrogates Ischemic Postconditioning Cardioprotection by Impairing AdipoR1/Caveolin-3/STAT3 Signaling in Diabetic Rats. Diabetes. PMID 26718505 DOI: 10.2337/Db15-0782  0.119
2024 Zhong S, Guo Q, Chen X, Luo X, Long Y, Chong T, Ye M, He H, Lu A, Ao K, Yin M, Xu A, Li X, Hao Y, Guo X. The inhibition of YTHDF3/mA/LRP6 reprograms fatty acid metabolism and suppresses lymph node metastasis in cervical cancer. International Journal of Biological Sciences. 20: 916-936. PMID 38250152 DOI: 10.7150/ijbs.87203  0.119
2024 Chui ZSW, Shen Q, Xu A. Current status and future perspectives of FGF21 analogues in clinical trials. Trends in Endocrinology and Metabolism: Tem. PMID 38423900 DOI: 10.1016/j.tem.2024.02.001  0.119
2017 Song E, Jahng JW, Chong LP, Sung HK, Han M, Luo C, Wu D, Boo S, Hinz B, Cooper MA, Robertson AA, Berger T, Mak TW, George I, Schulze PC, ... ... Xu A, et al. Lipocalin-2 induces NLRP3 inflammasome activation via HMGB1 induced TLR4 signaling in heart tissue of mice under pressure overload challenge. American Journal of Translational Research. 9: 2723-2735. PMID 28670364  0.119
2021 Cai Y, Liu H, Song E, Wang L, Xu J, He Y, Zhang D, Zhang L, Cheng KK, Jin L, Wu M, Liu S, Qi D, Zhang L, Lopaschuk GD, ... ... Xu A, et al. Deficiency of telomere-associated repressor activator protein 1 precipitates cardiac aging in mice p53/PPARα signaling. Theranostics. 11: 4710-4727. PMID 33754023 DOI: 10.7150/thno.51739  0.119
2024 Xia W, Zhang M, Liu C, Wang S, Xu A, Xia Z, Pang L, Cai Y. Exploring the therapeutic potential of tetrahydrobiopterin for heart failure with preserved ejection fraction: A path forward. Life Sciences. 122594. PMID 38537900 DOI: 10.1016/j.lfs.2024.122594  0.118
2014 Hui E, Xu A, Chow WS, Lee PC, Fong CH, Cheung SC, Tse HF, Chau MT, Cheung BM, Lam KS. Hypoadiponectinemia as an independent predictor for the progression of carotid atherosclerosis: a 5-year prospective study. Metabolic Syndrome and Related Disorders. 12: 517-22. PMID 25211296 DOI: 10.1089/met.2014.0024  0.118
2019 Harari A, Coster AC, Jenkins A, Xu A, Greenfield JR, Harats D, Shaish A, Samocha-Bonet D. Obesity and Insulin Resistance Are Inversely Associated with Serum and Adipose Tissue Carotenoid Concentrations in Adults. The Journal of Nutrition. PMID 31504714 DOI: 10.1093/jn/nxz184  0.118
2022 Luo JY, Cheng CK, He L, Pu Y, Zhang Y, Lin X, Xu A, Lau CW, Tian XY, Ma RCW, Jo H, Huang Y. Endothelial UCP2 Is a Mechanosensitive Suppressor of Atherosclerosis. Circulation Research. 101161CIRCRESAHA1223. PMID 35899624 DOI: 10.1161/CIRCRESAHA.122.321187  0.117
2016 Tonks KT, Coster AC, Christopher MJ, Chaudhuri R, Xu A, Gagnon-Bartsch J, Chisholm DJ, James DE, Meikle PJ, Greenfield JR, Samocha-Bonet D. Skeletal muscle and plasma lipidomic signatures of insulin resistance and overweight/obesity in humans. Obesity (Silver Spring, Md.). PMID 26916476 DOI: 10.1002/oby.21448  0.117
2011 Xiang Y, Zhou P, Li X, Huang G, Liu Z, Xu A, Leslie RD, Zhou Z. Heterogeneity of altered cytokine levels across the clinical spectrum of diabetes in China. Diabetes Care. 34: 1639-41. PMID 21617097 DOI: 10.2337/dc11-0039  0.117
2014 Lin Z, Wu F, Lin S, Pan X, Jin L, Lu T, Shi L, Wang Y, Xu A, Li X. Adiponectin protects against acetaminophen-induced mitochondrial dysfunction and acute liver injury by promoting autophagy in mice. Journal of Hepatology. 61: 825-31. PMID 24882054 DOI: 10.1016/j.jhep.2014.05.033  0.116
2012 Ong KL, Rye KA, O'Connell R, Jenkins AJ, Brown C, Xu A, Sullivan DR, Barter PJ, Keech AC. Long-term fenofibrate therapy increases fibroblast growth factor 21 and retinol-binding protein 4 in subjects with type 2 diabetes. The Journal of Clinical Endocrinology and Metabolism. 97: 4701-8. PMID 23144467 DOI: 10.1210/jc.2012-2267  0.116
2019 WU KK, XU A, CHENG KK. 248-LB: Deficiency of APPL1 in Macrophages Triggers Adipose Tissue Inflammation and Insulin Resistance by Potentiating NLRP3 Inflammasome Activation Diabetes. 68: 248-LB. DOI: 10.2337/DB19-248-LB  0.116
2022 Leung H, Long X, Ni Y, Qian L, Nychas E, Siliceo SL, Pohl D, Hanhineva K, Liu Y, Xu A, Nielsen HB, Belda E, Clément K, Loomba R, Li H, et al. Risk assessment with gut microbiome and metabolite markers in NAFLD development. Science Translational Medicine. 14: eabk0855. PMID 35675435 DOI: 10.1126/scitranslmed.abk0855  0.115
2015 Dong Z, Su L, Esmaili S, Iseli TJ, Ramezani-Moghadam M, Hu L, Xu A, George J, Wang J. Adiponectin attenuates liver fibrosis by inducing nitric oxide production of hepatic stellate cells. Journal of Molecular Medicine (Berlin, Germany). PMID 26153548 DOI: 10.1007/s00109-015-1313-z  0.115
2014 Liang Q, Zhong L, Zhang J, Wang Y, Bornstein SR, Triggle CR, Ding H, Lam KS, Xu A. FGF21 maintains glucose homeostasis by mediating the cross talk between liver and brain during prolonged fasting. Diabetes. 63: 4064-75. PMID 25024372 DOI: 10.2337/Db14-0541  0.115
2004 Lam KS, Xu A, Tan KC, Wong LC, Tiu SC, Tam S. Serum adiponectin is reduced in acromegaly and normalized after correction of growth hormone excess. The Journal of Clinical Endocrinology and Metabolism. 89: 5448-53. PMID 15531496 DOI: 10.1210/jc.2003-032023  0.115
2019 Pan Y, Feng T, Chan Y, Xu A, Lam K. OR01-3 MicroRNA-34a-Mediated FGF21 Resistance in the Adipose Tissue Contributes to Insulin Resistance and Hypoadiponectinemia in Diet-Induced Obesity Journal of the Endocrine Society. 3. DOI: 10.1210/JS.2019-OR01-3  0.115
2011 Li M, Ho JC, Lai KW, Au KK, Xu A, Cheung BM, Lam KS, Tse HF. The decrement in circulating endothelial progenitor cells (EPCs) in type 2 diabetes is independent of the severity of the hypoadiponectemia. Diabetes/Metabolism Research and Reviews. 27: 185-94. PMID 21294240 DOI: 10.1002/dmrr.1159  0.115
2021 Lee TH, Ahadullah, Christie BR, Lin K, Siu PM, Zhang L, Yuan TF, Komal P, Xu A, So KF, Yau SY. Chronic AdipoRon Treatment Mimics the Effects of Physical Exercise on Restoring Hippocampal Neuroplasticity in Diabetic Mice. Molecular Neurobiology. PMID 34164760 DOI: 10.1007/s12035-021-02441-7  0.115
2007 Yeung DC, Xu A, Cheung CW, Wat NM, Yau MH, Fong CH, Chau MT, Lam KS. Serum adipocyte fatty acid-binding protein levels were independently associated with carotid atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 1796-802. PMID 17510463 DOI: 10.1161/ATVBAHA.107.146274  0.114
2018 Wong YK, Cheung CYY, Tang CS, Au KW, Hai JSH, Lee CH, Lau KK, Cheung BMY, Sham PC, Xu A, Lam KSL, Tse HF. Age-Biomarkers-Clinical Risk Factors for Prediction of Cardiovascular Events in Patients With Coronary Artery Disease. Arteriosclerosis, Thrombosis, and Vascular Biology. 38: 2519-2527. PMID 30354221 DOI: 10.1161/ATVBAHA.118.311726  0.114
2005 Wang Y, Lam KS, Xu JY, Lu G, Xu LY, Cooper GJ, Xu A. Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. The Journal of Biological Chemistry. 280: 18341-7. PMID 15734737 DOI: 10.1074/jbc.M501149200  0.114
2010 Milner KL, van der Poorten D, Trenell M, Jenkins AB, Xu A, Smythe G, Dore GJ, Zekry A, Weltman M, Fragomeli V, George J, Chisholm DJ. Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance. Gastroenterology. 138: 932-41.e1-3. PMID 19962985 DOI: 10.1053/j.gastro.2009.11.050  0.114
2013 Liu M, Zhou M, Bao Y, Xu Z, Li H, Zhang H, Zhu W, Zhang J, Xu A, Wei M, Jia W. Circulating adipocyte fatty acid-binding protein levels are independently associated with heart failure. Clinical Science (London, England : 1979). 124: 115-22. PMID 23013043 DOI: 10.1042/CS20120004  0.113
2023 Mak JHC, Lui DT, Fong CH, Cheung CY, Wong Y, Lee AC, Hoo RL, Xu A, Tan KC, Lam KS, Lee CH. Serum thrombospondin-2 level changes with liver stiffness improvement in patients with type 2 diabetes. Clinical Endocrinology. PMID 38127469 DOI: 10.1111/cen.15010  0.113
2008 Liu J, Lam JB, Chow KH, Xu A, Lam KS, Moon RT, Wang Y. Adiponectin stimulates Wnt inhibitory factor-1 expression through epigenetic regulations involving the transcription factor specificity protein 1. Carcinogenesis. 29: 2195-202. PMID 18701434 DOI: 10.1093/carcin/bgn194  0.113
2010 Li H, Fang Q, Gao F, Fan J, Zhou J, Wang X, Zhang H, Pan X, Bao Y, Xiang K, Xu A, Jia W. Fibroblast growth factor 21 levels are increased in nonalcoholic fatty liver disease patients and are correlated with hepatic triglyceride. Journal of Hepatology. 53: 934-40. PMID 20675007 DOI: 10.1016/J.Jhep.2010.05.018  0.113
2010 Wong WT, Tian XY, Chen Y, Leung FP, Liu L, Lee HK, Ng CF, Xu A, Yao X, Vanhoutte PM, Tipoe GL, Huang Y. Bone morphogenic protein-4 impairs endothelial function through oxidative stress-dependent cyclooxygenase-2 upregulation: implications on hypertension. Circulation Research. 107: 984-91. PMID 20724703 DOI: 10.1161/Circresaha.110.222794  0.113
2015 Xu A, Sweeney G. Emerging role of autophagy in mediating widespread actions of ADIPOQ/adiponectin. Autophagy. 11: 723-4. PMID 25905437 DOI: 10.1080/15548627.2015.1034418  0.113
2007 Palanivel R, Fang X, Park M, Eguchi M, Pallan S, De Girolamo S, Liu Y, Wang Y, Xu A, Sweeney G. Globular and full-length forms of adiponectin mediate specific changes in glucose and fatty acid uptake and metabolism in cardiomyocytes. Cardiovascular Research. 75: 148-57. PMID 17499232 DOI: 10.1016/j.cardiores.2007.04.011  0.112
2012 Liu L, Liu J, Wong WT, Tian XY, Lau CW, Wang YX, Xu G, Pu Y, Zhu Z, Xu A, Lam KS, Chen ZY, Ng CF, Yao X, Huang Y. Dipeptidyl peptidase 4 inhibitor sitagliptin protects endothelial function in hypertension through a glucagon-like peptide 1-dependent mechanism. Hypertension. 60: 833-41. PMID 22868389 DOI: 10.1161/Hypertensionaha.112.195115  0.112
2013 Vu V, Liu Y, Sen S, Xu A, Sweeney G. Delivery of adiponectin gene to skeletal muscle using ultrasound targeted microbubbles improves insulin sensitivity and whole body glucose homeostasis. American Journal of Physiology. Endocrinology and Metabolism. 304: E168-75. PMID 23132298 DOI: 10.1152/ajpendo.00493.2012  0.112
2015 Peng J, Tsang JY, Ho DH, Zhang R, Xiao H, Li D, Zhu J, Wang F, Bian Z, Lui VC, Xu A, Tam PK, Lamb JR, Xia H, Chen Y. Modulatory effects of adiponectin on the polarization of tumor-associated macrophages. International Journal of Cancer. Journal International Du Cancer. 137: 848-58. PMID 25694398 DOI: 10.1002/Ijc.29485  0.112
2015 Liu Y, Wu G, Han L, Zhao K, Qu Y, Xu A, Huang Q. Association of the FABP2 Ala54Thr polymorphism with type 2 diabetes, obesity, and metabolic syndrome: a population-based case-control study and a systematic meta-analysis. Genetics and Molecular Research : Gmr. 14: 1155-68. PMID 25730055 DOI: 10.4238/2015.February.6.19  0.112
2017 von Loeffelholz C, Pfeiffer AF, Lock JF, Lieske S, Döcke S, Murahovschi V, Kriebel J, de Las Heras Gala T, Grallert H, Rudovich N, Stockmann M, Spranger J, Jahreis G, Bornstein SR, Lau G, ... Xu A, et al. ANGPTL8 (Betatrophin) is Expressed in Visceral Adipose Tissue and Relates to Human Hepatic Steatosis in Two Independent Clinical Collectives. Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Metabolisme. PMID 28351093 DOI: 10.1055/s-0043-102950  0.112
2024 Ng RC, Jian M, Ma OK, Xiang AW, Bunting M, Kwan JS, Wong CW, Yick LW, Chung SK, Lam KS, Alexander IE, Xu A, Chan KH. Liver-specific adiponectin gene therapy suppresses microglial NLRP3-inflammasome activation for treating Alzheimer's disease. Journal of Neuroinflammation. 21: 77. PMID 38539253 DOI: 10.1186/s12974-024-03066-y  0.112
2022 Zheng R, Xu A, Huang J, Zhang Z, Yin X, Zhang T, Hu W, Qian Y. A Rh(II)-catalyzed highly stereoselective [3 + 2] annulation of vinyl diazoacetates with indole-2-carbaldehyde for the synthesis of indolyl dihydrofurans. Molecular Diversity. PMID 35050450 DOI: 10.1007/s11030-022-10381-0  0.111
2017 Huang Z, Zhong L, Lee JTH, Zhang J, Wu D, Geng L, Wang Y, Wong CM, Xu A. The FGF21-CCL11 Axis Mediates Beiging of White Adipose Tissues by Coupling Sympathetic Nervous System to Type 2 Immunity. Cell Metabolism. PMID 28844880 DOI: 10.1016/J.Cmet.2017.08.003  0.111
2017 Lee CH, Woo YC, Chow WS, Cheung CYY, Fong CHY, Yuen MMA, Xu A, Tse HF, Lam KSL. Role of Circulating Fibroblast Growth Factor 21 Measurement in Primary Prevention of Coronary Heart Disease Among Chinese Patients With Type 2 Diabetes Mellitus. Journal of the American Heart Association. 6. PMID 28588089 DOI: 10.1161/JAHA.116.005344  0.111
2009 Law IK, Liu L, Xu A, Lam KS, Vanhoutte PM, Che CM, Leung PT, Wang Y. Identification and characterization of proteins interacting with SIRT1 and SIRT3: implications in the anti-aging and metabolic effects of sirtuins. Proteomics. 9: 2444-56. PMID 19343720 DOI: 10.1002/Pmic.200800738  0.111
2023 Wu M, Lo TH, Li L, Sun J, Deng C, Chan KY, Li X, Yeh ST, Lee JTH, Lui PPY, Xu A, Wong CM. Amelioration of non-alcoholic fatty liver disease by targeting adhesion G protein-coupled receptor F1 (). Elife. 12. PMID 37580962 DOI: 10.7554/eLife.85131  0.111
2020 Lee CH, Lui DTW, Cheung CYY, Fong CHY, Yuen MMA, Chow WS, Woo YC, Xu A, Lam KSL. Higher Circulating Adiponectin Concentrations Predict Incident Cancer in Type 2 Diabetes - The Adiponectin Paradox. The Journal of Clinical Endocrinology and Metabolism. PMID 32072163 DOI: 10.1210/clinem/dgaa075  0.111
2015 Ong KL, Januszewski AS, O'Connell R, Buizen L, Jenkins AJ, Xu A, Sullivan DR, Barter PJ, Scott RS, Taskinen MR, Rye KA, Keech AC. Relationship of fibroblast growth factor 21 with baseline and new on-study microvascular disease in the Fenofibrate Intervention and Event Lowering in Diabetes study. Diabetologia. PMID 26055067 DOI: 10.1007/s00125-015-3652-2  0.11
2013 Liang CF, Liu JT, Wang Y, Xu A, Vanhoutte PM. Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 777-84. PMID 23413427 DOI: 10.1161/ATVBAHA.112.301087  0.11
2023 Diaz-Canestro C, Chen J, Liu Y, Han H, Wang Y, Honoré E, Lee CH, Lam KSL, Tse MA, Xu A. A machine-learning algorithm integrating baseline serum proteomic signatures predicts exercise responsiveness in overweight males with prediabetes. Cell Reports. Medicine. 100944. PMID 36787735 DOI: 10.1016/j.xcrm.2023.100944  0.11
2014 Chatzigeorgiou A, Seijkens T, Zarzycka B, Engel D, Poggi M, Van Den Berg S, Soehnlein O, Winkels H, Beckers L, Lievens D, Driessen A, Kusters P, Biessen E, Garcia-Martin R, Ameln AKV, ... ... Xu A, et al. Blocking CD40-TRAF6 signaling is a therapeutic target in obesity-associated insulin resistance (Proceedings of the National Academy of Sciences of the United States of America (2014) 111, 7 (2686-2691) DOI: 10.1073/pnas.1400419111) Proceedings of the National Academy of Sciences of the United States of America. 111: 4644. DOI: 10.1073/Pnas.1403231111  0.11
2017 Zhang J, Li H, Zhou H, Fang L, Xu J, Yan H, Chen S, Song Q, Zhang Y, Xu A, Fang Q, Ye Y, Jia W. Lowered fasting chenodeoxycholic acid correlated with the decrease of fibroblast growth factor 19 in Chinese subjects with impaired fasting glucose. Scientific Reports. 7: 6042. PMID 28729691 DOI: 10.1038/s41598-017-06252-6  0.11
2013 Park M, Wu D, Park T, Choi CS, Li RK, Cheng KK, Xu A, Sweeney G. APPL1 transgenic mice are protected from high-fat diet-induced cardiac dysfunction. American Journal of Physiology. Endocrinology and Metabolism. 305: E795-804. PMID 23921137 DOI: 10.1152/Ajpendo.00257.2013  0.11
2022 Wu X, Cheung CKY, Ye D, Chakrabarti S, Mahajan H, Yan S, Song E, Yang W, Lee CH, Lam KSL, Wang C, Xu A. Serum Thrombospondin-2 Levels Are Closely Associated with the Severity of Metabolic Syndrome and Metabolic Associated Fatty Liver Disease. The Journal of Clinical Endocrinology and Metabolism. PMID 35532410 DOI: 10.1210/clinem/dgac292  0.11
2018 Wang B, Li A, Li X, Ho PW, Wu D, Wang X, Liu Z, Wu KK, Yau SS, Xu A, Cheng KK. Activation of hypothalamic RIP-Cre neurons promotes beiging of WAT via sympathetic nervous system. Embo Reports. PMID 29467283 DOI: 10.15252/Embr.201744977  0.11
2024 Li H, Zhang L, Li J, Wu Q, Qian L, He J, Ni Y, Kovatcheva-Datchary P, Yuan R, Liu S, Shen L, Zhang M, Sheng B, Li P, Kang K, ... ... Xu A, et al. Resistant starch intake facilitates weight loss in humans by reshaping the gut microbiota. Nature Metabolism. PMID 38409604 DOI: 10.1038/s42255-024-00988-y  0.109
2016 Chang J, Li Y, Huang Y, Lam KS, Hoo RL, Wong WT, Cheng KK, Wang Y, Vanhoutte PM, Xu A. Erratum. Adiponectin Prevents Diabetic Premature Senescence of Endothelial Progenitor Cells and Promotes Endothelial Repair by Suppressing the p38 MAP Kinase/p16INK4A Signaling Pathway. Diabetes 2010;59:2949-2959. Diabetes. 65: 3219. PMID 27659230 DOI: 10.2337/db16-er10b  0.109
2015 Tsai VW, Macia L, Feinle-Bisset C, Manandhar R, Astrup A, Raben A, Lorenzen JK, Schmidt PT, Wiklund F, Pedersen NL, Campbell L, Kriketos A, Xu A, Pengcheng Z, Jia W, et al. Serum Levels of Human MIC-1/GDF15 Vary in a Diurnal Pattern, Do Not Display a Profile Suggestive of a Satiety Factor and Are Related to BMI. Plos One. 10: e0133362. PMID 26207898 DOI: 10.1371/Journal.Pone.0133362  0.109
2014 Liu L, Liu J, Tian XY, Wong WT, Lau CW, Xu A, Xu G, Ng CF, Yao X, Gao Y, Huang Y. Uncoupling protein-2 mediates DPP-4 inhibitor-induced restoration of endothelial function in hypertension through reducing oxidative stress. Antioxidants & Redox Signaling. 21: 1571-81. PMID 24328731 DOI: 10.1089/Ars.2013.5519  0.109
2015 Li H, Hui X, Li P, Xu A, Li S, Jin S, Wu D. Expression and efficient purification of tag-cleaved active recombinant human insulin-like growth factor-II from Escherichia coli Biotechnology and Bioprocess Engineering. 20: 234-241. DOI: 10.1007/S12257-014-0562-Y  0.109
2013 Li H, Dong K, Fang Q, Hou X, Zhou M, Bao Y, Xiang K, Xu A, Jia W. High serum level of fibroblast growth factor 21 is an independent predictor of non-alcoholic fatty liver disease: a 3-year prospective study in China. Journal of Hepatology. 58: 557-63. PMID 23142063 DOI: 10.1016/j.jhep.2012.10.029  0.109
2016 Elie AG, Jensen PS, Nissen KD, Geraets IM, Xu A, Song E, Hansen ML, Irmukhamedov A, Rasmussen LM, Wang Y, De Mey JG. Adipokine Imbalance in the Pericardial Cavity of Cardiac and Vascular Disease Patients. Plos One. 11: e0154693. PMID 27139713 DOI: 10.1371/journal.pone.0154693  0.109
2023 Lee CH, Lui DT, Cheung CY, Fong CH, Yuen MM, Chow WS, Xu A, Lam KS. Circulating thrombospondin-2 level for identifying individuals with rapidly declining kidney function trajectory in type 2 diabetes: a prospective study of the Hong Kong West Diabetes Registry. Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association. PMID 36857285 DOI: 10.1093/ndt/gfad034  0.109
2024 Bai J, Liu D, Tian X, Wang Y, Cui B, Yang Y, Dai S, Lin W, Zhu J, Wang J, Xu A, Gu Z, Zhang S. Coin-sized, fully integrated, and minimally invasive continuous glucose monitoring system based on organic electrochemical transistors. Science Advances. 10: eadl1856. PMID 38640241 DOI: 10.1126/sciadv.adl1856  0.109
2016 Wang H, Zhang H, Zhang Z, Huang B, Cheng X, Wang D, la Gahu Z, Xue Z, Da Y, Li D, Yao Z, Gao F, Xu A, Zhang R. Adiponectin-derived active peptide ADP355 exerts anti-inflammatory and anti-fibrotic activities in thioacetamide-induced liver injury. Scientific Reports. 6: 19445. PMID 26777428 DOI: 10.1038/srep19445  0.109
2014 Cheng KK, Zhu W, Chen B, Wang Y, Wu D, Sweeney G, Wang B, Lam KS, Xu A. The adaptor protein APPL2 inhibits insulin-stimulated glucose uptake by interacting with TBC1D1 in skeletal muscle. Diabetes. 63: 3748-58. PMID 24879834 DOI: 10.2337/Db14-0337  0.109
2015 Lee CH, Hui EY, Woo YC, Yeung CY, Chow WS, Yuen MM, Fong CH, Xu A, Lam KS. Circulating fibroblast growth factor 21 levels predict progressive kidney disease in subjects with type 2 diabetes and normoalbuminuria. The Journal of Clinical Endocrinology and Metabolism. 100: 1368-75. PMID 25625802 DOI: 10.1210/jc.2014-3465  0.109
2023 Wang H, Hu L, Li H, Lai YT, Wei X, Xu X, Cao Z, Cao H, Wan Q, Chang YY, Xu A, Zhou Q, Jiang G, He ML, Sun H. Mitochondrial ATP synthase as a direct molecular target of chromium(III) to ameliorate hyperglycaemia stress. Nature Communications. 14: 1738. PMID 36977671 DOI: 10.1038/s41467-023-37351-w  0.108
2013 Baretella O, Chung SK, Xu A, Vanhoutte PM. Heterozygous overexpression of preproendothelin-1 in endothelial cells enhances thromboxane–/INS;prostanoid receptor-induced contractions in the renal artery of obese mice Life Sciences. 93: e5. DOI: 10.1016/J.LFS.2013.12.203  0.108
2007 Chen J, Sun M, Liang B, Xu A, Zhang S, Wu D. Cloning and expression of PDK4, FOXO1A and DYRK1A from the hibernating greater horseshoe bat (Rhinolophus ferrumequinum). Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology. 146: 166-71. PMID 17140834 DOI: 10.1016/j.cbpb.2006.10.095  0.108
2011 Lee MY, Li H, Xiao Y, Zhou Z, Xu A, Vanhoutte PM. Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells. British Journal of Pharmacology. 162: 1564-76. PMID 21175571 DOI: 10.1111/j.1476-5381.2010.01158.x  0.108
2017 Gao C, Chen X, Xu A, Cheng K, Shen J. Adaptor Protein APPL2 Affects Adult Antidepressant Behaviors and Hippocampal Neurogenesis via Regulating the Sensitivity of Glucocorticoid Receptor. Molecular Neurobiology. PMID 28965332 DOI: 10.1007/s12035-017-0785-y  0.108
2012 Zhou M, Xu A, Tam PK, Lam KS, Huang B, Liang Y, Lee IK, Wu D, Wang Y. Upregulation of UCP2 by adiponectin: the involvement of mitochondrial superoxide and hnRNP K. Plos One. 7: e32349. PMID 22359684 DOI: 10.1371/Journal.Pone.0032349  0.107
2013 Liu J, Xu A, Lam KS, Wong NS, Chen J, Shepherd PR, Wang Y. Cholesterol-induced mammary tumorigenesis is enhanced by adiponectin deficiency: role of LDL receptor upregulation. Oncotarget. 4: 1804-18. PMID 24113220 DOI: 10.18632/oncotarget.1364  0.107
2021 Ong KL, Wu L, Januszewski AS, O'Connell R, Xu A, Scott RS, Sullivan DR, Rye KA, Li H, Ma RC, Li L, Gebski V, Jenkins AJ, Jia W, Keech AC. The relationship of neutrophil elastase and proteinase 3 with risk factors, and chronic complications in type 2 diabetes: A Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) sub-study. Diabetes & Vascular Disease Research. 18: 14791641211032547. PMID 34275349 DOI: 10.1177/14791641211032547  0.107
2016 Jiang X, Zhou Y, Wu KK, Chen Z, Xu A, Cheng KK. APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes. Diabetologia. PMID 28011992 DOI: 10.1007/s00125-016-4185-z  0.107
2014 Li H, Wei S, Cheng K, Gounko NV, Ericksen RE, Xu A, Hong W, Han W. BIG3 inhibits insulin granule biogenesis and insulin secretion. Embo Reports. 15: 714-22. PMID 24711543 DOI: 10.1002/Embr.201338181  0.107
2023 Shi Y, Wang CC, Wu L, Zhang Y, Xu A, Wang Y. Pathophysiological Insight into Fatty Acid-Binding Protein-4: Multifaced Roles in Reproduction, Pregnancy, and Offspring Health. International Journal of Molecular Sciences. 24. PMID 37628833 DOI: 10.3390/ijms241612655  0.107
2012 Alkharfy KM, Al-Daghri NM, Vanhoutte PM, Krishnaswamy S, Xu A. Serum retinol-binding protein 4 as a marker for cardiovascular disease in women. Plos One. 7: e48612. PMID 23119072 DOI: 10.1371/journal.pone.0048612  0.107
2023 Ni Y, Qian L, Siliceo SL, Long X, Nychas E, Liu Y, Ismaiah MJ, Leung H, Zhang L, Gao Q, Wu Q, Zhang Y, Jia X, Liu S, Yuan R, ... ... Xu A, et al. Resistant starch decreases intrahepatic triglycerides in patients with NAFLD via gut microbiome alterations. Cell Metabolism. 35: 1530-1547.e8. PMID 37673036 DOI: 10.1016/j.cmet.2023.08.002  0.107
2015 Xiao Y, Liu L, Xu A, Zhou P, Long Z, Tu Y, Chen X, Tang W, Huang G, Zhou Z. Serum fibroblast growth factor 21 levels are related to subclinical atherosclerosis in patients with type 2 diabetes. Cardiovascular Diabetology. 14: 72. PMID 26047614 DOI: 10.1186/s12933-015-0229-9  0.106
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2019 Zhang J, Li H, Bai N, Xu Y, Song Q, Zhang L, Wu G, Chen S, Hou X, Wang C, Wei L, Xu A, Fang Q, Jia W. Decrease of FGF19 contributes to the increase of fasting glucose in human in an insulin-independent manner. Journal of Endocrinological Investigation. PMID 30852757 DOI: 10.1007/s40618-019-01018-5  0.106
2022 Zhao P, Xu A, Leung WK. Obesity, Bone Loss, and Periodontitis: The Interlink. Biomolecules. 12. PMID 35883424 DOI: 10.3390/biom12070865  0.105
2014 Huang B, Cheng X, Wang D, Peng M, Xue Z, Da Y, Zhang N, Yao Z, Li M, Xu A, Zhang R. Adiponectin promotes pancreatic cancer progression by inhibiting apoptosis via the activation of AMPK/Sirt1/PGC-1α signaling. Oncotarget. 5: 4732-45. PMID 25051362 DOI: 10.18632/oncotarget.1963  0.105
2018 Liu JJ, Liu S, Choo RW, Wee SL, Xu A, Lim SC. Sex modulates the association of fibroblast growth factor 21 with end-stage renal disease in Asian people with Type 2 diabetes: a 6.3-year prospective cohort study. Diabetic Medicine : a Journal of the British Diabetic Association. PMID 29653030 DOI: 10.1111/dme.13641  0.105
2021 Cheung CYY, Lee CH, Fong CHY, Chow W, Woo YC, Yuen M, Tan KCB, Xu A, Sham PC, Lam KSL. Identification of ANXA2 as a Potential Susceptibility Gene for Diabetic Retinopathy in a Genome-Wide Association Analysis in Chinese Patients With Type 2 Diabetes Mellitus Journal of the Endocrine Society. 5: A414-A415. DOI: 10.1210/jendso/bvab048.846  0.105
2017 Ong KL, O'Connell R, Januszewski AS, Jenkins AJ, Xu A, Sullivan DR, Barter PJ, Scott RS, Taskinen MR, Waldman B, Colman PG, Best JD, Simes JR, Rye KA, Keech AC, et al. Baseline Circulating FGF21 Concentrations and Increase after Fenofibrate Treatment Predict More Rapid Glycemic Progression in Type 2 Diabetes: Results from the FIELD Study. Clinical Chemistry. PMID 28606915 DOI: 10.1373/clinchem.2016.270876  0.105
2018 Yau SY, Lee TH, Li A, Xu A, So KF. Adiponectin Mediates Running-Restored Hippocampal Neurogenesis in Streptozotocin-Induced Type 1 Diabetes in Mice. Frontiers in Neuroscience. 12: 679. PMID 30333718 DOI: 10.3389/fnins.2018.00679  0.105
2012 Chen C, Tso AWK, Cheung BMY, Law LSC, Ong KL, Wat NMS, Janus ED, Xu A, Lam KSL. Plasma concentration of pigment epithelium-derived factor is closely associated with blood pressure and predicts incident hypertension in Chinese: A 10-year prospective study Clinical Endocrinology. 76: 506-513. PMID 21777264 DOI: 10.1111/j.1365-2265.2011.04178.x  0.105
2014 Liu T, Li H, Gounko NV, Zhou Z, Xu A, Hong W, Han W. Detection of insulin granule exocytosis by an electrophysiology method with high temporal resolution reveals enlarged insulin granule pool in BIG3-knockout mice. American Journal of Physiology. Endocrinology and Metabolism. 307: E611-8. PMID 25139048 DOI: 10.1152/Ajpendo.00208.2014  0.104
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2009 Yau MH, Wang Y, Lam KS, Zhang J, Wu D, Xu A. A highly conserved motif within the NH2-terminal coiled-coil domain of angiopoietin-like protein 4 confers its inhibitory effects on lipoprotein lipase by disrupting the enzyme dimerization. The Journal of Biological Chemistry. 284: 11942-52. PMID 19246456 DOI: 10.1074/Jbc.M809802200  0.104
2005 Ding X, Saxena NK, Lin S, Xu A, Xu A, Srinivasan S, Anania FA. The roles of leptin and adiponectin: a novel paradigm in adipocytokine regulation of liver fibrosis and stellate cell biology. The American Journal of Pathology. 166: 1655-69. PMID 15920151 DOI: 10.1016/S0002-9440(10)62476-5  0.104
2013 Wang T, Mao X, Li H, Qiao S, Xu A, Wang J, Lei S, Liu Z, Ng KF, Wong GT, Vanhoutte PM, Irwin MG, Xia Z. N-Acetylcysteine and allopurinol up-regulated the Jak/STAT3 and PI3K/Akt pathways via adiponectin and attenuated myocardial postischemic injury in diabetes. Free Radical Biology & Medicine. 63: 291-303. PMID 23747931 DOI: 10.1016/J.Freeradbiomed.2013.05.043  0.104
2006 Wang Y, Lam JB, Lam KS, Liu J, Lam MC, Hoo RL, Wu D, Cooper GJ, Xu A. Adiponectin modulates the glycogen synthase kinase-3beta/beta-catenin signaling pathway and attenuates mammary tumorigenesis of MDA-MB-231 cells in nude mice. Cancer Research. 66: 11462-70. PMID 17145894 DOI: 10.1158/0008-5472.Can-06-1969  0.104
2009 Yeung DC, Lam KS, Wang Y, Tso AW, Xu A. Serum zinc-alpha2-glycoprotein correlates with adiposity, triglycerides, and the key components of the metabolic syndrome in Chinese subjects. The Journal of Clinical Endocrinology and Metabolism. 94: 2531-6. PMID 19351730 DOI: 10.1210/jc.2009-0058  0.104
2015 Cai Y, Manio MM, Leung GP, Xu A, Tang EH, Vanhoutte PM. Thyroid hormone affects both endothelial and vascular smooth muscle cells in rat arteries. European Journal of Pharmacology. 747: 18-28. PMID 25489922 DOI: 10.1016/j.ejphar.2014.11.036  0.104
2016 Wang XQ, Lo CM, Chen L, Ngan ES, Xu A, Poon RY. CDK1-PDK1-PI3K/Akt signaling pathway regulates embryonic and induced pluripotency. Cell Death and Differentiation. PMID 27636107 DOI: 10.1038/Cdd.2016.84  0.104
2011 Chow KH, Liu J, Sun RW, Vanhoutte PM, Xu A, Chen J, Che CM, Wang Y. The gold (III) porphyrin complex, gold-2a, suppresses WNT1 expression in breast cancer cells by enhancing the promoter association of YY1. American Journal of Translational Research. 3: 479-91. PMID 22046489  0.104
2016 Yang JK, Wang YY, Liu C, Shi TT, Lu J, Cao X, Yang FY, Feng JP, Chen C, Ji LN, Xu A. Urine Proteome Specific for Eye Damage Can Predict Kidney Damage in Patients With Type 2 Diabetes: A Case-Control and a 5.3-Year Prospective Cohort Study. Diabetes Care. PMID 27903615 DOI: 10.2337/dc16-1529  0.104
2020 Liao B, Geng L, Zhang F, Shu L, Wei L, Yeung PKK, Lam KSL, Chung SK, Chang J, Vanhoutte PM, Xu A, Wang K, Hoo RLC. Adipocyte fatty acid-binding protein exacerbates cerebral ischaemia injury by disrupting the blood-brain barrier. European Heart Journal. PMID 32350521 DOI: 10.1093/eurheartj/ehaa207  0.103
2012 Bai B, Liang Y, Xu C, Lee MY, Xu A, Wu D, Vanhoutte PM, Wang Y. Cyclin-dependent kinase 5-mediated hyperphosphorylation of sirtuin-1 contributes to the development of endothelial senescence and atherosclerosis. Circulation. 126: 729-40. PMID 22753194 DOI: 10.1161/Circulationaha.112.118778  0.103
2018 Huang J, Xiao Y, Zheng P, Zhou W, Wang Y, Huang G, Xu A, Zhou Z. Distinct neutrophil counts and functions in patients with newly diagnosed type 1 diabetes, latent autoimmune diabetes in adults, and type 2 diabetes. Diabetes/Metabolism Research and Reviews. e3064. PMID 30123986 DOI: 10.1002/dmrr.3064  0.103
2021 Xiang Y, Liu B, Yun C, Zhou P, Li X, Luo S, Xie Z, Che Z, Lin J, Yang L, Li X, Huang G, Xu A, Zhou Z. Frequency, clinical features, inflammatory cytokines and genetic background of latent autoimmune diabetes in youth in youth-onset type 2 diabetes (LADA China study): a nationwide, multicenter, clinic-based cross-sectional study. Diabetes, Obesity & Metabolism. PMID 33528883 DOI: 10.1111/dom.14336  0.103
2011 Cheung CYY, Tso AWK, Cheung BMY, Xu A, Ong KL, Law LSC, Wat NMS, Janus ED, Sham PC, Lam KSL. Genetic variants associated with persistent central obesity and the metabolic syndrome in a 12-year longitudinal study European Journal of Endocrinology. 164: 381-388. PMID 21147891 DOI: 10.1530/EJE-10-0902  0.102
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2009 Leung KC, Xu A, Craig ME, Martin A, Lam KS, O'Sullivan AJ. Adiponectin isoform distribution in women--relationship to female sex steroids and insulin sensitivity. Metabolism: Clinical and Experimental. 58: 239-45. PMID 19154958 DOI: 10.1016/j.metabol.2008.09.020  0.102
2020 Ng KKK, Cheung CYY, Lee CH, Fong CHY, Kwok KHM, Li KKW, Gangwani RA, Wong IYH, Woo YC, Chow WS, Yuen MMA, Wong RLC, Xu A, Wong DSH, Sham PC, et al. Possible Modifying Effect of Hemoglobin A1c on Genetic Susceptibility to Severe Diabetic Retinopathy in Patients With Type 2 Diabetes. Investigative Ophthalmology & Visual Science. 61: 7. PMID 32756921 DOI: 10.1167/iovs.61.10.7  0.102
2008 Yang YH, Wang Y, Lam KS, Yau MH, Cheng KK, Zhang J, Zhu W, Wu D, Xu A. Suppression of the Raf/MEK/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 835-40. PMID 18340008 DOI: 10.1161/Atvbaha.107.157776  0.102
2016 Cheung CY, Tang CS, Xu A, Lee CH, Au KW, Xu L, Fong CH, Kwok KH, Chow WS, Woo YC, Yuen MM, Hai JS, Jin YL, Cheung BM, Tan KC, et al. Exome-chip association analysis reveals an Asian-specific missense variant in PAX4 associated with type 2 diabetes in Chinese individuals. Diabetologia. PMID 27744525 DOI: 10.1007/S00125-016-4132-Z  0.101
2016 Ye D, Yang K, Zang S, Lin Z, Chau HT, Wang Y, Zhang J, Shi J, Xu A, Lin S, Wang Y. Lipocalin-2 Mediates Nonalcoholic Steatohepatitis by Promoting Neutrophil-Macrophage Crosstalk via The Induction of CXCR2. Journal of Hepatology. PMID 27266617 DOI: 10.1016/j.jhep.2016.05.041  0.101
2012 Ye D, Li FY, Lam KS, Li H, Jia W, Wang Y, Man K, Lo CM, Li X, Xu A. Toll-like receptor-4 mediates obesity-induced non-alcoholic steatohepatitis through activation of X-box binding protein-1 in mice. Gut. 61: 1058-67. PMID 22253482 DOI: 10.1136/gutjnl-2011-300269  0.101
2019 Wong YK, Cheung CYY, Tang CS, Hai JSH, Lee CH, Lau KK, Au KW, Cheung BMY, Sham PC, Xu A, Lam KSL, Tse HF. High-sensitivity troponin I and B-type natriuretic peptide biomarkers for prediction of cardiovascular events in patients with coronary artery disease with and without diabetes mellitus. Cardiovascular Diabetology. 18: 171. PMID 31847896 DOI: 10.1186/s12933-019-0974-2  0.101
2012 Yuen CY, Wong SL, Lau CW, Tsang SY, Xu A, Zhu Z, Ng CF, Yao X, Kong SK, Lee HK, Huang Y. From skeleton to cytoskeleton: osteocalcin transforms vascular fibroblasts to myofibroblasts via angiotensin II and Toll-like receptor 4. Circulation Research. 111: e55-66. PMID 22679141 DOI: 10.1161/Circresaha.112.271361  0.1
2014 Yau SY, Li A, Hoo RL, Ching YP, Christie BR, Lee TM, Xu A, So KF. Physical exercise-induced hippocampal neurogenesis and antidepressant effects are mediated by the adipocyte hormone adiponectin. Proceedings of the National Academy of Sciences of the United States of America. 111: 15810-5. PMID 25331877 DOI: 10.1073/Pnas.1415219111  0.1
2014 Jüllig M, Yip S, Xu A, Smith G, Middleditch M, Booth M, Babor R, Beban G, Murphy R. Lower fetuin-A, retinol binding protein 4 and several metabolites after gastric bypass compared to sleeve gastrectomy in patients with type 2 diabetes. Plos One. 9: e96489. PMID 24800810 DOI: 10.1371/journal.pone.0096489  0.1
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2018 Lee CH, Cheung CYY, Woo YC, Lui DTW, Yuen MMA, Fong CHY, Chow WS, Xu A, Lam KSL. Circulating Adipocyte Fatty Acid-Binding Protein Concentrations Predict Multiple Mortality Outcomes among Men and Women with Diabetes. Clinical Chemistry. PMID 30021923 DOI: 10.1373/clinchem.2018.289157  0.099
2010 Chow KH, Sun RW, Lam JB, Li CK, Xu A, Ma DL, Abagyan R, Wang Y, Che CM. A gold(III) porphyrin complex with antitumor properties targets the Wnt/beta-catenin pathway. Cancer Research. 70: 329-37. PMID 19996284 DOI: 10.1158/0008-5472.Can-09-3324  0.098
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2006 Man K, Zhao Y, Xu A, Lo CM, Lam KS, Ng KT, Ho JW, Sun CK, Lee TK, Li XL, Fan ST. Fat-derived hormone adiponectin combined with FTY720 significantly improves small-for-size fatty liver graft survival. American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons. 6: 467-76. PMID 16468955 DOI: 10.1111/j.1600-6143.2005.01201.x  0.098
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2010 Li H, Lam A, Xu AM, Lam KS, Chung SK. High dosage of Exendin-4 increased early insulin secretion in differentiated beta cells from mouse embryonic stem cells. Acta Pharmacologica Sinica. 31: 570-7. PMID 20418895 DOI: 10.1038/aps.2010.38  0.097
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2010 Cheung CYY, Tso AWK, Cheung BMY, Xu A, Ong KL, Fong CHY, Wat NMS, Janus ED, Sham PC, Lam KSL. Obesity susceptibility genetic variants identified from recent genome-wide association studies: Implications in a Chinese population Journal of Clinical Endocrinology and Metabolism. 95: 1395-1403. PMID 20061430 DOI: 10.1210/jc.2009-1465  0.095
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2008 Stöckli J, Davey JR, Hohnen-Behrens C, Xu A, James DE, Ramm G. Regulation of glucose transporter 4 translocation by the Rab guanosine triphosphatase-activating protein AS160/TBC1D4: role of phosphorylation and membrane association. Molecular Endocrinology (Baltimore, Md.). 22: 2703-15. PMID 18801932 DOI: 10.1210/me.2008-0111  0.093
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