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Robert F. Spurney - Publications

Affiliations: 
Duke University, Durham, NC 
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46 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Wang L, Chang JH, Buckley AF, Spurney RF. Knockout of TRPC6 promotes insulin resistance and exacerbates glomerular injury in Akita mice. Kidney International. 95: 321-332. PMID 30665571 DOI: 10.1016/J.Kint.2018.09.026  0.329
2018 Wang L, Buckley AF, Spurney RF. Regulation of cofilin phosphorylation in glomerular podocytes by testis specific kinase 1 (TESK1). Scientific Reports. 8: 12286. PMID 30115939 DOI: 10.1038/S41598-018-30115-3  0.465
2018 Hall G, Lane BM, Khan K, Pediaditakis I, Xiao J, Wu G, Wang L, Kovalik ME, Chryst-Stangl M, Davis EE, Spurney RF, Gbadegesin RA. The Human FSGS-Causing R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes. Journal of the American Society of Nephrology : Jasn. PMID 30002222 DOI: 10.1681/Asn.2017121338  0.336
2017 Hall G, Spurney RF. Losing their footing: Rac1 signaling causes podocyte detachment and FSGS. Kidney International. 92: 283-285. PMID 28709595 DOI: 10.1016/J.Kint.2017.03.045  0.314
2015 Wang L, Jirka G, Rosenberg PB, Buckley AF, Gomez JA, Fields TA, Winn MP, Spurney RF. Gq signaling causes glomerular injury by activating TRPC6. The Journal of Clinical Investigation. 125: 1913-26. PMID 25844902 DOI: 10.1172/Jci76767  0.389
2014 Hall G, Rowell J, Farinelli F, Gbadegesin RA, Lavin P, Wu G, Homstad A, Malone A, Lindsey T, Jiang R, Spurney R, Tomaselli GF, Kass DA, Winn MP. Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity. American Journal of Physiology. Renal Physiology. 306: F1442-50. PMID 24740790 DOI: 10.1152/Ajprenal.00212.2013  0.445
2012 Wang X, Liao S, Nelson ER, Schmalzigaug R, Spurney RF, Guilak F, Premont RT, Gesty-Palmer D. The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis. Biochemical and Biophysical Research Communications. 425: 407-12. PMID 22846567 DOI: 10.1016/J.Bbrc.2012.07.111  0.578
2012 Zhang JD, Patel MB, Song YS, Griffiths R, Burchette J, Ruiz P, Sparks MA, Yan M, Howell DN, Gomez JA, Spurney RF, Coffman TM, Crowley SD. A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension. Circulation Research. 110: 1604-17. PMID 22534490 DOI: 10.1161/Circresaha.111.261768  0.335
2012 Wang L, Ellis MJ, Gomez JA, Eisner W, Fennell W, Howell DN, Ruiz P, Fields TA, Spurney RF. Mechanisms of the proteinuria induced by Rho GTPases. Kidney International. 81: 1075-85. PMID 22278020 DOI: 10.1038/Ki.2011.472  0.36
2011 Wang L, Chang JH, Paik SY, Tang Y, Eisner W, Spurney RF. Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo. Molecular Endocrinology (Baltimore, Md.). 25: 1376-86. PMID 21622531 DOI: 10.1210/Me.2011-0029  0.347
2011 Koh J, Dar M, Untch BR, Dixit D, Shi Y, Yang Z, Adam MA, Dressman H, Wang X, Gesty-Palmer D, Marks JR, Spurney R, Druey KM, Olson JA. Regulator of G protein signaling 5 is highly expressed in parathyroid tumors and inhibits signaling by the calcium-sensing receptor. Molecular Endocrinology (Baltimore, Md.). 25: 867-76. PMID 21393447 DOI: 10.1210/Me.2010-0277  0.371
2009 Gesty-Palmer D, Flannery P, Yuan L, Corsino L, Spurney R, Lefkowitz RJ, Luttrell LM. A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. Science Translational Medicine. 1: 1ra1. PMID 20368153 DOI: 10.1126/Scitranslmed.3000071  0.67
2009 Wang L, Gesty-Palmer D, Fields TA, Spurney RF. Inhibition of WNT signaling by G protein-coupled receptor (GPCR) kinase 2 (GRK2). Molecular Endocrinology (Baltimore, Md.). 23: 1455-65. PMID 19556343 DOI: 10.1210/Me.2009-0084  0.416
2009 Hartle JE, Prpic V, Siddhanti SR, Spurney RF, Quarles LD. Differential regulation of receptor‐stimulated cyclic adenosine monophosphate production by polyvalent cations in MC3T3‐E1 osteoblasts Journal of Bone and Mineral Research. 11: 789-799. PMID 8725176 DOI: 10.1002/Jbmr.5650110610  0.442
2008 Wang L, Flannery PJ, Rosenberg PB, Fields TA, Spurney RF. Gq-dependent signaling upregulates COX2 in glomerular podocytes. Journal of the American Society of Nephrology : Jasn. 19: 2108-18. PMID 18667730 DOI: 10.1681/Asn.2008010113  0.389
2008 Wang L, Ellis MJ, Fields TA, Howell DN, Spurney RF. Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis. Kidney & Blood Pressure Research. 31: 111-21. PMID 18367845 DOI: 10.1159/000121531  0.382
2006 Wang L, Flannery PJ, Athirakul K, Dunn SR, Kourany WM, Spurney RF. Galphaq-dependent signaling cascades stimulate water-seeking behavior. American Journal of Physiology. Renal Physiology. 291: F781-9. PMID 16609148 DOI: 10.1152/Ajprenal.00401.2005  0.322
2006 Flannery PJ, Spurney RF. Transactivation of the epidermal growth factor receptor by angiotensin II in glomerular podocytes. Nephron. Experimental Nephrology. 103: e109-18. PMID 16554661 DOI: 10.1159/000092196  0.397
2006 Gesty-Palmer D, Chen M, Reiter E, Ahn S, Nelson CD, Wang S, Eckhardt AE, Cowan CL, Spurney RF, Luttrell LM, Lefkowitz RJ. Distinct beta-arrestin- and G protein-dependent pathways for parathyroid hormone receptor-stimulated ERK1/2 activation. The Journal of Biological Chemistry. 281: 10856-64. PMID 16492667 DOI: 10.1074/Jbc.M513380200  0.712
2005 Wang L, Fields TA, Pazmino K, Dai Q, Burchette JL, Howell DN, Coffman TM, Spurney RF. Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury. Journal of the American Society of Nephrology : Jasn. 16: 3611-22. PMID 16267159 DOI: 10.1681/Asn.2005020167  0.392
2005 Crowley SD, Gurley SB, Oliverio MI, Pazmino AK, Griffiths R, Flannery PJ, Spurney RF, Kim HS, Smithies O, Le TH, Coffman TM. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. The Journal of Clinical Investigation. 115: 1092-9. PMID 15841186 DOI: 10.1172/Jci23378  0.357
2005 Pi M, Oakley RH, Gesty-Palmer D, Cruickshank RD, Spurney RF, Luttrell LM, Quarles LD. Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. Molecular Endocrinology (Baltimore, Md.). 19: 1078-87. PMID 15637145 DOI: 10.1210/Me.2004-0450  0.66
2005 Wang L, Liu S, Quarles LD, Spurney RF. Targeted overexpression of G protein-coupled receptor kinase-2 in osteoblasts promotes bone loss. American Journal of Physiology. Endocrinology and Metabolism. 288: E826-34. PMID 15585587 DOI: 10.1152/Ajpendo.00422.2004  0.361
2004 Wang L, Quarles LD, Spurney RF. Unmasking the osteoinductive effects of a G-protein-coupled receptor (GPCR) kinase (GRK) inhibitor by treatment with PTH(1-34). Journal of Bone and Mineral Research : the Official Journal of the American Society For Bone and Mineral Research. 19: 1661-70. PMID 15355561 DOI: 10.1359/Jbmr.040708  0.391
2003 Thomas DW, Rocha PN, Nataraj C, Robinson LA, Spurney RF, Koller BH, Coffman TM. Proinflammatory actions of thromboxane receptors to enhance cellular immune responses. Journal of Immunology (Baltimore, Md. : 1950). 171: 6389-95. PMID 14662837 DOI: 10.4049/Jimmunol.171.12.6389  0.337
2003 Wang L, Flannery PJ, Spurney RF. Characterization of angiotensin II-receptor subtypes in podocytes. The Journal of Laboratory and Clinical Medicine. 142: 313-21. PMID 14647035 DOI: 10.1016/S0022-2143(03)00139-2  0.359
2003 Le TH, Kim HS, Allen AM, Spurney RF, Smithies O, Coffman TM. Physiological impact of increased expression of the AT1 angiotensin receptor. Hypertension. 42: 507-14. PMID 12963678 DOI: 10.1161/01.Hyp.0000092000.07559.57  0.315
2003 Tharaux PL, Bukoski RC, Rocha PN, Crowley SD, Ruiz P, Nataraj C, Howell DN, Kaibuchi K, Spurney RF, Coffman TM. Rho kinase promotes alloimmune responses by regulating the proliferation and structure of T cells. Journal of Immunology (Baltimore, Md. : 1950). 171: 96-105. PMID 12816987 DOI: 10.4049/Jimmunol.171.1.96  0.436
2002 Flannery PJ, Spurney RF. Desensitization of the mouse thromboxane A2 receptor (TP) by G protein-coupled receptor kinases (Grks). Prostaglandins & Other Lipid Mediators. 70: 79-90. PMID 12428680 DOI: 10.1016/S0090-6980(02)00013-8  0.462
2002 Pi M, Spurney RF, Tu Q, Hinson T, Quarles LD. Calcium-sensing receptor activation of rho involves filamin and rho-guanine nucleotide exchange factor. Endocrinology. 143: 3830-8. PMID 12239094 DOI: 10.1210/En.2002-220240  0.434
2002 Spurney RF, Flannery PJ, Garner SC, Athirakul K, Liu S, Guilak F, Quarles LD. Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts. The Journal of Clinical Investigation. 109: 1361-71. PMID 12021252 DOI: 10.1172/Jci14663  0.472
2001 Flannery PJ, Spurney RF. Domains of the parathyroid hormone (PTH) receptor required for regulation by G protein-coupled receptor kinases (GRKs) Biochemical Pharmacology. 62: 1047-1058. PMID 11597573 DOI: 10.1016/S0006-2952(01)00749-3  0.464
2000 Pi M, Garner SC, Flannery P, Spurney RF, Quarles L. Sensing of extracellular cations in CasR-deficient osteoblasts. Evidence for a novel cation-sensing mechanism. Journal of Biological Chemistry. 275: 3256-3263. PMID 10652312 DOI: 10.1074/Jbc.275.5.3256  0.333
1999 Hall RA, Spurney RF, Premont RT, Rahman N, Blitzer JT, Pitcher JA, Lefkowitz RJ. G protein-coupled receptor kinase 6A phosphorylates the Na(+)/H(+) exchanger regulatory factor via a PDZ domain-mediated interaction. The Journal of Biological Chemistry. 274: 24328-34. PMID 10446210 DOI: 10.1074/Jbc.274.34.24328  0.64
1999 Spurney RF, Pi M, Flannery P, Quarles LD. Aluminum is a weak agonist for the calcium-sensing receptor. Kidney International. 55: 1750-1758. PMID 10231437 DOI: 10.1046/J.1523-1755.1999.00432.X  0.305
1998 Spurney RF. Role Of C-Terminal Serines In Desensitization And Phosphorylation Of The Mouse Thromboxane Receptor Journal of Biological Chemistry. 273: 28496-28503. PMID 9774479 DOI: 10.1074/Jbc.273.43.28496  0.429
1998 Spurney RF. Effect of Receptor Number on Desensitization of the Mouse Thromboxane Receptor Biochemical Pharmacology. 55: 1271-1281. PMID 9719483 DOI: 10.1016/S0006-2952(97)00633-3  0.415
1998 Coffman TM, Spurney RF, Mannon RB, Levenson R. Thromboxane A2 modulates the fibrinolytic system in glomerular mesangial cells. The American Journal of Physiology. 275: F262-9. PMID 9691017 DOI: 10.1152/Ajprenal.1998.275.2.F262  0.42
1998 Weinman EJ, Steplock D, Tate K, Hall RA, Spurney RF, Shenolikar S. Structure-function of recombinant Na/H exchanger regulatory factor (NHE-RF). The Journal of Clinical Investigation. 101: 2199-206. PMID 9593775 DOI: 10.1172/Jci204  0.549
1995 Nebigil CG, Garnovskaya MN, Spurney RF, Raymond JR. Identification of a rat glomerular mesangial cell mitogenic 5-HT2A receptor American Journal of Physiology-Renal Physiology. 268. PMID 7840237 DOI: 10.1152/Ajprenal.1995.268.1.F122  0.612
1994 Spurney RF, Middleton JP, Raymond JR, Coffman TM. Modulation of thromboxane receptor activation in rat glomerular mesangial cells. The American Journal of Physiology. 267: F467-78. PMID 8092261 DOI: 10.1152/Ajprenal.1994.267.3.F467  0.411
1993 Spurney RF, Onorato JJ, Albers FJ, Coffman TM. Thromboxane binding and signal transduction in rat glomerular mesangial cells American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 264. PMID 8447439 DOI: 10.1152/Ajprenal.1993.264.2.F292  0.361
1992 Ruiz P, Rey L, Spurney R, Coffman T, Viciana A. Thromboxane augmentation of alloreactive t cell function Transplantation. 54: 498-505. PMID 1412730 DOI: 10.1097/00007890-199209000-00021  0.325
1991 Spurney RF, Ruiz P, Pisetsky DS, Coffman TM. Enhanced renal leukotriene production in murine lupus: Role of lipoxygenase metabolites Kidney International. 39: 95-102. PMID 1848329 DOI: 10.1038/Ki.1991.12  0.312
1991 Spurney RF, Bernstein RJ, Ruiz P, Pisetsky DS, Coffman TM. Physiological role for enhanced renal thromboxane production in murine lupus nephritis Prostaglandins. 42: 15-28. PMID 1771236 DOI: 10.1016/0090-6980(91)90090-3  0.318
1990 Spurney RF, Mayros SD, Collins D, Ruiz P, Klotman PE, Coffman T. Thromboxane receptor blockade improves cyclosporine nephrotoxicity in rats Prostaglandins. 39: 135-146. PMID 2138344 DOI: 10.1016/0090-6980(90)90070-C  0.32
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