Jan H. Koeman - Publications

Affiliations: 
Toxicology Wageningen University, Wageningen, Gelderland, Netherlands 
Area:
toxicology

68 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2012 Rietjens IM, Boersma MG, Haan Ld, Spenkelink B, Awad HM, Cnubben NH, van Zanden JJ, Woude Hv, Alink GM, Koeman JH. The pro-oxidant chemistry of the natural antioxidants vitamin C, vitamin E, carotenoids and flavonoids. Environmental Toxicology and Pharmacology. 11: 321-33. PMID 21782615 DOI: 10.1016/s1382-6689(02)00003-0  0.273
2012 Mensink BP, Kralt H, Vethaak AD, Ten Hallers-Tjabbes CC, Koeman JH, van Hattum B, Boon JP. Imposex induction in laboratory reared juvenile Buccinum undatum by tributyltin (TBT). Environmental Toxicology and Pharmacology. 11: 49-65. PMID 21782586 DOI: 10.1016/s1382-6689(01)00106-5  0.317
2009 Garthoff JA, Heemskerk S, Hempenius RA, Lina BA, Krul CA, Koeman JH, Speijers GJ. Safety evaluation of pectin-derived acidic oligosaccharides (pAOS): genotoxicity and sub-chronic studies. Regulatory Toxicology and Pharmacology : Rtp. 57: 31-42. PMID 20026148 DOI: 10.1016/j.yrtph.2009.12.004  0.303
2005 Blankvoort BM, Rodenburg RJ, Murk AJ, Koeman JH, Schilt R, Aarts JM. Androgenic activity in surface water samples detected using the AR-LUX assay: indications for mixture effects. Environmental Toxicology and Pharmacology. 19: 263-72. PMID 21783485 DOI: 10.1016/j.etap.2004.08.004  0.287
2004 Meerts IA, Lilienthal H, Hoving S, van den Berg JH, Weijers BM, Bergman A, Koeman JH, Brouwer A. Developmental exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107): long-term effects on brain development, behavior, and brain stem auditory evoked potentials in rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 82: 207-18. PMID 15310863 DOI: 10.1093/toxsci/kfh252  0.245
2004 Meerts IA, Hoving S, van den Berg JH, Weijers BM, Swarts HJ, van der Beek EM, Bergman A, Koeman JH, Brouwer A. Effects of in utero exposure to 4-hydroxy-2,3,3',4',5-pentachlorobiphenyl (4-OH-CB107) on developmental landmarks, steroid hormone levels, and female estrous cyclicity in rats. Toxicological Sciences : An Official Journal of the Society of Toxicology. 82: 259-67. PMID 15310862 DOI: 10.1093/toxsci/kfh251  0.307
2003 Jeuken A, Keser BJ, Khan E, Brouwer A, Koeman J, Denison MS. Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables, and fruits. Journal of Agricultural and Food Chemistry. 51: 5478-87. PMID 12926901 DOI: 10.1021/Jf030252U  0.309
2003 Hamers T, van den Brink PJ, Mos L, van der Linden SC, Legler J, Koeman JH, Murk AJ. Estrogenic and esterase-inhibiting potency in rainwater in relation to pesticide concentrations, sampling season and location. Environmental Pollution (Barking, Essex : 1987). 123: 47-65. PMID 12663205 DOI: 10.1016/s0269-7491(02)00364-0  0.319
2002 Bast A, Chandler RF, Choy PC, Delmulle LM, Gruenwald J, Halkes SB, Keller K, Koeman JH, Peters P, Przyrembel H, de Ree EM, Renwick AG, Vermeer IT. Botanical health products, positioning and requirements for effective and safe use. Environmental Toxicology and Pharmacology. 12: 195-211. PMID 21782639 DOI: 10.1016/S1382-6689(02)00035-2  0.224
2002 de Roode DF, Gustavsson MB, Rantalainen AL, Klomp AV, Koeman JH, Bosveldt AT. Embryotoxic potential of persistent organic pollutants extracted from tissues of guillemots (Uria aalge) from the Baltic Sea and the Atlantic Ocean. Environmental Toxicology and Chemistry / Setac. 21: 2401-11. PMID 12389920  0.222
2002 Hamers T, Smit LA, Bosveld AT, van den Berg JH, Koeman JH, van Schooten FJ, Murk AJ. Lack of a distinct gradient in biomarker responses in small mammals collected at different distances from a highway. Archives of Environmental Contamination and Toxicology. 43: 345-55. PMID 12202932 DOI: 10.1007/s00244-002-1230-3  0.314
2002 Meerts IA, Assink Y, Cenijn PH, Van Den Berg JH, Weijers BM, Bergman A, Koeman JH, Brouwer A. Placental transfer of a hydroxylated polychlorinated biphenyl and effects on fetal and maternal thyroid hormone homeostasis in the rat. Toxicological Sciences : An Official Journal of the Society of Toxicology. 68: 361-71. PMID 12151632  0.254
2002 Legler J, Dennekamp M, Vethaak AD, Brouwer A, Koeman JH, van der Burg B, Murk AJ. Detection of estrogenic activity in sediment-associated compounds using in vitro reporter gene assays. The Science of the Total Environment. 293: 69-83. PMID 12109482 DOI: 10.1016/s0048-9697(01)01146-9  0.307
2001 Hamers T, Smit MG, Murk AJ, Koeman JH. Biological and chemical analysis of the toxic potency of pesticides in rainwater. Chemosphere. 45: 609-24. PMID 11680757 DOI: 10.1016/s0045-6535(01)00017-0  0.306
2001 Vermeulen NP, Seegal RF, Koeman JH. ETAP changes. Environmental Toxicology and Pharmacology. 10: V. PMID 11382557 DOI: 10.1016/s1382-6689(01)00086-2  0.176
2000 van der Plas SA, Sundberg H, van den Berg H, Scheu G, Wester P, Jensen S, Bergman A, de Boer J, Koeman JH, Brouwer A. Contribution of planar (0-1 ortho) and nonplanar (2-4 ortho) fractions of Aroclor 1260 to the induction of altered hepatic foci in female Sprague-Dawley rats. Toxicology and Applied Pharmacology. 169: 255-68. PMID 11133348 DOI: 10.1006/taap.2000.9058  0.339
2000 Hamers T, van Schaardenburg, Felzel EC, Murk AJ, Koeman JH. The application of reporter gene assays for the determination of the toxic potency of diffuse air pollution. The Science of the Total Environment. 262: 159-74. PMID 11059851 DOI: 10.1016/s0048-9697(00)00600-8  0.297
2000 Hamers T, Molin KR, Koeman JH, Murk AJ. A small-volume bioassay for quantification of the esterase inhibiting potency of mixtures of organophosphate and carbamate insecticides in rainwater: development and optimization. Toxicological Sciences : An Official Journal of the Society of Toxicology. 58: 60-7. PMID 11053541 DOI: 10.1093/toxsci/58.1.60  0.286
2000 de Roode DF, Balk L, Koeman JH. Development of a bioassay to test the possible role of thiamine disturbance as a mechanism behind pollution-induced reproductive failures in birds. Archives of Environmental Contamination and Toxicology. 39: 386-91. PMID 10948290 DOI: 10.1007/s002440010119  0.291
2000 Koeman JH, Vermeulen NP. Editorial. Environmental Toxicology and Pharmacology. 8: 71. PMID 10867364 DOI: 10.1016/s1382-6689(00)00043-0  0.165
1999 van Iersel ML, Cnubben NH, Smink N, Koeman JH, van Bladeren PJ. Interactions of prostaglandin A2 with the glutathione-mediated biotransformation system. Biochemical Pharmacology. 57: 1383-90. PMID 10353259 DOI: 10.1016/s0006-2952(99)00048-9  0.32
1999 van der Plas SA, Haag-Grönlund M, Scheu G, Wärngård L, van den Berg M, Wester P, Koeman JH, Brouwer A. Induction of altered hepatic foci by a mixture of dioxin-like compounds with and without 2,2',4,4',5,5'-hexachlorobiphenyl in female Sprague-Dawley rats. Toxicology and Applied Pharmacology. 156: 30-9. PMID 10101096 DOI: 10.1006/taap.1999.8629  0.351
1998 Mensink A, Mul FP, van der Wijk T, Brouwer A, Koeman JH. Macrophages influence gap junctional intercellular communication between smooth muscle cells in a co-culture model. Environmental Toxicology and Pharmacology. 5: 197-203. PMID 21781865 DOI: 10.1016/s1382-6689(98)00002-7  0.224
1998 Essers AJ, Alink GM, Speijers GJ, Alexander J, Bouwmeister PJ, van den Brandt PA, Ciere S, Gry J, Herrman J, Kuiper HA, Mortby E, Renwick AG, Shrimpton DH, Vainio H, Vittozzi L, ... Koeman JH, et al. Food plant toxicants and safety Risk assessment and regulation of inherent toxicants in plant foods. Environmental Toxicology and Pharmacology. 5: 155-72. PMID 21781862 DOI: 10.1016/s1382-6689(98)00003-9  0.277
1998 Besselink HT, Denison MS, Hahn ME, Karchner SI, Vethaak AD, Koeman JH, Brouwer A. Low inducibility of cyp1a activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): Characterization of the Ah receptor and the role of CYP1A inhibition Toxicological Sciences. 43: 161-171. PMID 9710958 DOI: 10.1006/Toxs.1998.2455  0.346
1998 Rijnkels JM, Hollanders VM, Woutersen RA, Koeman JH, Alink GM. Absence of an inhibitory effect of a vegetables-fruit mixture on the initiation and promotion phases of azoxymethane-induced colorectal carcinogenesis in rats fed low- or high-fat diets. Nutrition and Cancer. 30: 124-9. PMID 9589430 DOI: 10.1080/01635589809514651  0.299
1997 Jansen LA, de Vrije T, Koeman JH, Jongen WM. The role of calcium in the tumor promoter-induced inhibition of gap junctional intercellular communication. Environmental Toxicology and Pharmacology. 3: 13-6. PMID 21781752 DOI: 10.1016/s1382-6689(96)00132-9  0.235
1997 Rijnkels JM, Hollanders VM, Woutersen RA, Koeman JH, Alink GM. Modulation of dietary fat-enhanced colorectal carcinogenesis in N-methyl-N'-nitro-N-nitrosoguanidine-treated rats by a vegetables-fruit mixture. Nutrition and Cancer. 29: 90-5. PMID 9383790 DOI: 10.1080/01635589709514607  0.318
1997 Rijnkels JM, Hollanders VM, Woutersen RA, Koeman JH, Alink GM. Interaction of dietary fat and of a vegetables/fruit mixture on 1,2-dimethylhydrazine- or N-methyl-N'-nitro-N-nitrosoguanidine-induced colorectal cancer in rats. Cancer Letters. 114: 297-8. PMID 9103314 DOI: 10.1016/s0304-3835(97)04685-5  0.255
1997 Rijnkels JM, Hollanders VM, Woutersen RA, Koeman JH, Alink GM. Interaction of dietary fat with a vegetables-fruit mixture on 1,2-dimethylhydrazine-induced colorectal cancer in rats. Nutrition and Cancer. 27: 261-6. PMID 9101556 DOI: 10.1080/01635589709514536  0.326
1996 De Haan LH, Halfwerk S, Hovens SE, De Roos B, Koeman JH, Brouwer A. Inhibition of intercellular communication and induction of ethoxyresorufin-O-deethylase activity by polychlorobiphenyls, -dibenzo-p-dioxins and -dibenzofurans in mouse hepa1c1c7 cells. Environmental Toxicology and Pharmacology. 1: 27-37. PMID 21781660 DOI: 10.1016/1382-6689(95)00006-2  0.304
1996 Haenen HE, Bleijlevens E, Elzerman H, Temmink JH, Koeman JH, Van Bladeren PJ. Cytotoxicity of 2-tert-butyl hydroquinone glutathione conjugates after apical and basolateral exposure of rat renal proximal tubular cell monolayers. Toxicology in Vitro : An International Journal Published in Association With Bibra. 10: 141-8. PMID 20650192 DOI: 10.1016/0887-2333(95)00116-6  0.329
1996 Besselink HT, van Beusekom S, Roex E, Vethaak AD, Koeman JH, Brouwer A. Low hepatic 7-ethoxyresorufin-O-deethylase (EROD) activity and minor alterations in retinoid and thyroid hormone levels in flounder (Platichthys flesus) exposed to the polychlorinated biphenyl (PCB) mixture, Clophen A50. Environmental Pollution (Barking, Essex : 1987). 92: 267-74. PMID 15091378 DOI: 10.1016/0269-7491(95)00116-6  0.315
1996 Haenen HE, Spenkelink A, Teunissen C, Temmink JH, Koeman JH, van Bladeren PJ. Transport and metabolism of glutathione conjugates of menadione and ethacrynic acid in confluent monolayers of rat renal proximal tubular cells. Toxicology. 112: 117-30. PMID 8814341 DOI: 10.1016/0300-483x(96)82323-7  0.277
1996 Morse DC, Wehler EK, Wesseling W, Koeman JH, Brouwer A. Alterations in rat brain thyroid hormone status following pre- and postnatal exposure to polychlorinated biphenyls (Aroclor 1254). Toxicology and Applied Pharmacology. 136: 269-79. PMID 8619235 DOI: 10.1006/taap.1996.0034  0.314
1996 Huggett AC, Schilter B, Roberfroid M, Antignac E, Koeman JH. Comparative methods of toxicity testing. Consensus document following an International Life Sciences Institute-ILSI Europe Workshop held in May 1995. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 34: 183-92. PMID 8606035 DOI: 10.1016/0278-6915(95)00098-4  0.22
1995 Wolterbeek AP, Roggeband R, van Moorsel CJ, Baan RA, Koeman JH, Feron VJ, Rutten AA. Vitamin A and beta-carotene influence the level of benzo[a]pyrene-induced DNA adducts and DNA-repair activities in hamster tracheal epithelium in organ culture. Cancer Letters. 91: 205-14. PMID 7767911 DOI: 10.1016/0304-3835(95)03740-n  0.254
1995 Van Birgelen AP, Smit EA, Kampen IM, Groeneveld CN, Fase KM, Van der Kolk J, Poiger H, Van den Berg M, Koeman JH, Brouwer A. Subchronic effects of 2,3,7,8-TCDD or PCBs on thyroid hormone metabolism: use in risk assessment. European Journal of Pharmacology. 293: 77-85. PMID 7672011 DOI: 10.1016/0926-6917(95)90021-7  0.349
1995 Mensink A, de Haan LH, Lakemond CM, Koelman CA, Koeman JH. Inhibition of gap junctional intercellular communication between primary human smooth muscle cells by tumor necrosis factor alpha. Carcinogenesis. 16: 2063-7. PMID 7554055 DOI: 10.1093/carcin/16.9.2063  0.234
1994 Murk AJ, Van den Berg JH, Fellinger M, Rozemeijer MJ, Swennen C, Duiven P, Boon JP, Brouwer A, Koeman JH. Toxic and biochemical effects of 3,3',4,4'-tetrachlorobiphenyl (CB-77) and clophen A50 on eider duckling (Somateria mollissima) in a semi-field experiment. Environmental Pollution (Barking, Essex : 1987). 86: 21-30. PMID 15091645  0.331
1994 de Haan LH, Bosselaers I, Jongen WM, Zwijsen RM, Koeman JH. Effect of lipids and aldehydes on gap-junctional intercellular communication between human smooth muscle cells. Carcinogenesis. 15: 253-6. PMID 8313516 DOI: 10.1093/carcin/15.2.253  0.285
1994 Lans MC, Spiertz C, Brouwer A, Koeman JH. Different competition of thyroxine binding to transthyretin and thyroxine-binding globulin by hydroxy-PCBs, PCDDs and PCDFs. European Journal of Pharmacology. 270: 129-36. PMID 8039542 DOI: 10.1016/0926-6917(94)90054-x  0.23
1994 Groten JP, Koeman JH, van Nesselrooij JH, Luten JB, Fentener van Vlissingen JM, Stenhuis WS, van Bladeren PJ. Comparison of renal toxicity after long-term oral administration of cadmium chloride and cadmium-metallothionein in rats. Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology. 23: 544-52. PMID 7867906 DOI: 10.1006/faat.1994.1139  0.295
1994 Gangolli SD, Brandt PAvd, Feron VJ, Janzowsky C, Koeman JH, Speijers GJA, Spiegelhalder B, Walker R, Wishnok JS. Nitrate, nitrite and N-nitroso compounds. European Journal of Pharmacology: Environmental Toxicology and Pharmacology. 292: 1-38. PMID 7867685 DOI: 10.1016/0926-6917(94)90022-1  0.318
1993 den Besten C, Bennik MH, Bruggeman I, Schielen P, Kuper F, Brouwer A, Koeman JH, Vos JG, Van Bladeren PJ. The role of oxidative metabolism in hexachlorobenzene-induced porphyria and thyroid hormone homeostasis: a comparison with pentachlorobenzene in a 13-week feeding study. Toxicology and Applied Pharmacology. 119: 181-94. PMID 8480328 DOI: 10.1006/taap.1993.1059  0.369
1993 Alink GM, Kuiper HA, Hollanders VM, Koeman JH. Effect of heat processing and of vegetables and fruit in human diets on 1,2-dimethylhydrazine-induced colon carcinogenesis in rats. Carcinogenesis. 14: 519-24. PMID 8453729 DOI: 10.1093/carcin/14.3.519  0.328
1993 Koeman JH. [Secondary poisoning (toxic substances in food chains): advice from the Public Health Council]. Nederlands Tijdschrift Voor Geneeskunde. 137: 2012-4. PMID 8413714  0.281
1993 Morse DC, Groen D, Veerman M, van Amerongen CJ, Koëter HB, Smits van Prooije AE, Visser TJ, Koeman JH, Brouwer A. Interference of polychlorinated biphenyls in hepatic and brain thyroid hormone metabolism in fetal and neonatal rats. Toxicology and Applied Pharmacology. 122: 27-33. PMID 8378931 DOI: 10.1006/taap.1993.1168  0.299
1993 Hempenius RA, Dellevoet SM, Marsman G, Koeman JH, de Vries J. Toxicity of methyl linoleate ozonide in the rat. Toxicology. 80: 189-98. PMID 8327999 DOI: 10.1016/0300-483x(93)90180-z  0.309
1992 Heussen GA, Hikspoors ML, Spenkelink A, Brouwer A, Koeman JH. Inhibition of binding of thyroxin to transthyretin by outdoor and indoor airborne particulate matter and effects on thyroid hormone and vitamin A metabolism in rats. Archives of Environmental Contamination and Toxicology. 23: 6-12. PMID 1637200 DOI: 10.1007/BF00225989  0.328
1992 Zwijsen RM, Japenga SC, Heijen AM, van den Bos RC, Koeman JH. Induction of platelet-derived growth factor chain A gene expression in human smooth muscle cells by oxidized low density lipoproteins. Biochemical and Biophysical Research Communications. 186: 1410-6. PMID 1510670 DOI: 10.1016/s0006-291x(05)81563-3  0.229
1991 Murk AJ, van den Berg JH, Koeman JH, Brouwer A. The toxicity of tetrachlorobenzyltoluenes (Ugilec 141) and polychlorobiphenyls (Aroclor 1254 and PCB-77) compared in Ah-responsive and Ah-nonresponsive mice. Environmental Pollution (Barking, Essex : 1987). 72: 57-67. PMID 15092114  0.311
1991 Hoogenboom LA, van Kammen M, Berghmans MC, Koeman JH, Kuiper HA. The use of pig hepatocytes to study the nature of protein-bound metabolites of furazolidone: a new analytical method for their detection. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 29: 321-8. PMID 2060890  0.291
1991 Tiedink HG, de Haan LH, Jongen WM, Koeman JH. In-vitro testing and the carcinogenic potential of several nitrosated indole compounds. Cell Biology and Toxicology. 7: 371-86. PMID 1794111 DOI: 10.1007/BF00124072  0.31
1991 Koeman JH. From comparative physiology to toxicological risk assessment. Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology. 100: 7-10. PMID 1677876 DOI: 10.1016/0742-8413(91)90111-6  0.265
1990 Zwijsen RM, de Haan LH, Oosting JS, Pekelharing HL, Koeman JH. Inhibition of intercellular communication in smooth muscle cells of humans and rats by low density lipoprotein, cigarette smoke condensate and TPA. Atherosclerosis. 85: 71-80. PMID 2282109 DOI: 10.1016/0021-9150(90)90184-k  0.279
1989 Everts JW, Aukema B, Hengeveld R, Koeman JH. Side-effects of pesticides on ground-dwelling predatory arthropods in arable ecosystems. Environmental Pollution (Barking, Essex : 1987). 59: 203-25. PMID 15092403 DOI: 10.1016/0269-7491(89)90227-3  0.257
1989 Vos RM, Lutkeschipholt IJ, Boonekamp PM, Schots A, Pomp H, Van Bladeren PJ, Koeman JH. Monoclonal antibodies against rat glutathione S-transferase isoenzymes 2-2 and 3-3. Hybridoma. 8: 475-80. PMID 2777277 DOI: 10.1089/hyb.1989.8.475  0.23
1989 Alink GM, Kuiper HA, Beems RB, Koeman JH. A study on the carcinogenicity of human diets in rats: the influence of heating and the addition of vegetables and fruit. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 27: 427-36. PMID 2777146 DOI: 10.1016/0278-6915(89)90028-8  0.326
1988 Vroomen LH, Berghmans MC, Groten JP, Koeman JH, van Bladeren PJ. Reversible interaction of a reactive intermediate derived from furazolidone with glutathione and protein. Toxicology and Applied Pharmacology. 95: 53-60. PMID 3413795 DOI: 10.1016/s0041-008x(88)80007-3  0.26
1988 van Houdt JJ, Coenen PW, Alink GM, Boleij JS, Koeman JH. Organ specific metabolic activation of five extracts of indoor and outdoor particulate matter. Archives of Toxicology. 61: 213-7. PMID 3355366 DOI: 10.1007/BF00316636  0.291
1988 Rutten AA, Jongen WM, de Haan LH, Hendriksen EG, Koeman JH. Effect of retinol and cigarette-smoke condensate on dye-coupled intercellular communication between hamster tracheal epithelial cells. Carcinogenesis. 9: 315-20. PMID 3338116 DOI: 10.1093/carcin/9.2.315  0.283
1988 Alink GM, Reijven PL, Sijtsma SR, Jongen WM, Topp RJ, Kuiper HA, Koeman JH. Effects of human diets on biotransformation enzyme activity and metabolic activation of carcinogens in rat liver. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 26: 883-91. PMID 3209128 DOI: 10.1016/0278-6915(88)90085-3  0.353
1983 Koeman JH. Ecotoxicology and environmental quality. Environmental Monitoring and Assessment. 3: 227-8. PMID 24259086 DOI: 10.1007/BF00396215  0.2
1982 van der Hoeven JC, Bruggeman IM, Alink GM, Koeman JH. The killifish Nothobranchius rachowi, a new animal in genetic toxicology. Mutation Research. 97: 35-42. PMID 7057797 DOI: 10.1016/0165-1161(82)90017-6  0.246
1981 Koeman JH, Strik JJ. Environmental toxicology, its history and future with special attention to the situation in the Netherlands. The Veterinary Quarterly. 3: 196-9. PMID 7292471 DOI: 10.1080/01652176.1981.9693827  0.28
1981 Hansen LG, Strik JJ, Koeman JH, Kan CA. Biological activity of technical Aroclor 1254 compared to Aroclor 1254 residues: swine fat residues fed to broiler cockerels. Toxicology. 21: 203-12. PMID 6794187 DOI: 10.1016/0300-483x(81)90156-6  0.323
1970 Koeman JH, Pennings JH. An orientational survey on the side-effects and environmental distribution of insecticides used in tsetse-control in Africa. Bulletin of Environmental Contamination and Toxicology. 5: 164-70. PMID 24185809 DOI: 10.1007/BF01617195  0.215
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