Kenneth D. Philipson - Publications

Affiliations: 
UCLA - School of Medicine 

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Lotteau S, Zhang R, Hazan A, Grabar C, Gonzalez D, Aynaszyan S, Philipson KD, Ottolia M, Goldhaber JI. Acute Genetic Ablation of Cardiac Sodium/Calcium Exchange in Adult Mice: Implications for Cardiomyocyte Calcium Regulation, Cardioprotection, and Arrhythmia. Journal of the American Heart Association. e019273. PMID 34472363 DOI: 10.1161/JAHA.120.019273  0.63
2020 Yue X, Hazan A, Lotteau S, Zhang R, Torrente AG, Philipson KD, Ottolia M, Goldhaber JI. Na/Ca exchange in the atrium: Role in sinoatrial node pacemaking and excitation-contraction coupling. Cell Calcium. 87: 102167. PMID 32028091 DOI: 10.1016/J.Ceca.2020.102167  0.551
2017 Yue X, Zhang R, Kim B, Ma A, Philipson KD, Goldhaber JI. Heterogeneity of transverse-axial tubule system in mouse atria: Remodeling in atrial-specific Na(+)-Ca(2+) exchanger knockout mice. Journal of Molecular and Cellular Cardiology. PMID 28529049 DOI: 10.1016/j.yjmcc.2017.05.008  0.613
2017 Torrente AG, Zhang R, Wang H, Zaini A, Kim B, Yue X, Philipson KD, Goldhaber JI. Contribution of small conductance K(+) channels to sinoatrial node pacemaker activity: insights from atrial-specific Na(+) /Ca(2+) exchange knockout mice. The Journal of Physiology. PMID 28346695 DOI: 10.1113/JP274249  0.576
2015 Torrente AG, Zhang R, Zaini A, Giani JF, Kang J, Lamp ST, Philipson KD, Goldhaber JI. Burst pacemaker activity of the sinoatrial node in sodium-calcium exchanger knockout mice. Proceedings of the National Academy of Sciences of the United States of America. PMID 26195795 DOI: 10.1073/pnas.1505670112  0.596
2015 Kapoor N, Tran A, Kang J, Zhang R, Philipson KD, Goldhaber JI. Regulation of calcium clock-mediated pacemaking by inositol-1,4,5-trisphosphate receptors in mouse sinoatrial nodal cells. The Journal of Physiology. 593: 2649-63. PMID 25903031 DOI: 10.1113/JP270082  0.494
2015 Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, et al. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. The Journal of Physiology. 593: 1361-82. PMID 25772291 DOI: 10.1113/Jphysiol.2014.282319  0.492
2014 Burr AR, Millay DP, Goonasekera SA, Park KH, Sargent MA, Collins J, Altamirano F, Philipson KD, Allen PD, Ma J, López JR, Molkentin JD. Na+ dysregulation coupled with Ca2+ entry through NCX1 promotes muscular dystrophy in mice. Molecular and Cellular Biology. 34: 1991-2002. PMID 24662047 DOI: 10.1128/Mcb.00339-14  0.49
2013 Groenke S, Larson ED, Alber S, Zhang R, Lamp ST, Ren X, Nakano H, Jordan MC, Karagueuzian HS, Roos KP, Nakano A, Proenza C, Philipson KD, Goldhaber JI. Complete atrial-specific knockout of sodium-calcium exchange eliminates sinoatrial node pacemaker activity. Plos One. 8: e81633. PMID 24278453 DOI: 10.1371/Journal.Pone.0081633  0.537
2013 Ottolia M, Torres N, Bridge JH, Philipson KD, Goldhaber JI. Na/Ca exchange and contraction of the heart. Journal of Molecular and Cellular Cardiology. 61: 28-33. PMID 23770352 DOI: 10.1016/J.Yjmcc.2013.06.001  0.688
2013 Goldhaber JI, Philipson KD. Cardiac sodium-calcium exchange and efficient excitation-contraction coupling: implications for heart disease. Advances in Experimental Medicine and Biology. 961: 355-64. PMID 23224894 DOI: 10.1007/978-1-4614-4756-6_30  0.596
2013 Ottolia M, Philipson KD. NCX1: mechanism of transport. Advances in Experimental Medicine and Biology. 961: 49-54. PMID 23224869 DOI: 10.1007/978-1-4614-4756-6_5  0.636
2013 Nicoll DA, Ottolia M, Goldhaber JI, Philipson KD. 20 years from NCX purification and cloning: milestones. Advances in Experimental Medicine and Biology. 961: 17-23. PMID 23224866 DOI: 10.1007/978-1-4614-4756-6_2  0.579
2013 Bai Y, Morgan EE, Giovannucci DR, Pierre SV, Philipson KD, Askari A, Liu L. Different roles of the cardiac Na+/Ca2+-exchanger in ouabain-induced inotropy, cell signaling, and hypertrophy. American Journal of Physiology. Heart and Circulatory Physiology. 304: H427-35. PMID 23203972 DOI: 10.1152/Ajpheart.00462.2012  0.454
2013 Gao Z, Rasmussen TP, Li Y, Kutschke W, Koval OM, Wu Y, Wu Y, Hall DD, Joiner ML, Wu XQ, Swaminathan PD, Purohit A, Zimmerman K, Weiss RM, Philipson KD, et al. Genetic inhibition of Na+-Ca2+ exchanger current disables fight or flight sinoatrial node activity without affecting resting heart rate. Circulation Research. 112: 309-17. PMID 23192947 DOI: 10.1161/Circresaha.111.300193  0.343
2012 Pott C, Muszynski A, Ruhe M, Bögeholz N, Schulte JS, Milberg P, Mönnig G, Fabritz L, Goldhaber JI, Breithardt G, Schmitz W, Philipson KD, Eckardt L, Kirchhof P, Müller FU. Proarrhythmia in a non-failing murine model of cardiac-specific Na+/Ca 2+ exchanger overexpression: whole heart and cellular mechanisms. Basic Research in Cardiology. 107: 247. PMID 22327339 DOI: 10.1007/s00395-012-0247-7  0.608
2012 Besserer GM, Nicoll DA, Abramson J, Philipson KD. Characterization and purification of a Na+/Ca2+ exchanger from an archaebacterium. The Journal of Biological Chemistry. 287: 8652-9. PMID 22287543 DOI: 10.1074/jbc.M111.331280  0.684
2011 John SA, Ribalet B, Weiss JN, Philipson KD, Ottolia M. Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers. Proceedings of the National Academy of Sciences of the United States of America. 108: 1699-704. PMID 21209335 DOI: 10.1073/Pnas.1016114108  0.498
2010 Chen L, Zhang J, Hu X, Philipson KD, Scharf SM. The Na+/Ca2+ exchanger-1 mediates left ventricular dysfunction in mice with chronic intermittent hypoxia. Journal of Applied Physiology (Bethesda, Md. : 1985). 109: 1675-85. PMID 20947716 DOI: 10.1152/japplphysiol.01372.2009  0.323
2010 Neco P, Rose B, Huynh N, Zhang R, Bridge JH, Philipson KD, Goldhaber JI. Sodium-calcium exchange is essential for effective triggering of calcium release in mouse heart. Biophysical Journal. 99: 755-64. PMID 20682252 DOI: 10.1016/j.bpj.2010.04.071  0.641
2010 Larbig R, Torres N, Bridge JH, Goldhaber JI, Philipson KD. Activation of reverse Na+-Ca2+ exchange by the Na+ current augments the cardiac Ca2+ transient: evidence from NCX knockout mice. The Journal of Physiology. 588: 3267-76. PMID 20643777 DOI: 10.1113/jphysiol.2010.187708  0.692
2010 Ottolia M, Nicoll DA, John S, Philipson KD. Interactions between Ca2+ binding domains of the Na+-Ca2+ exchanger and secondary regulation. Channels (Austin, Tex.). 4: 159-62. PMID 20224291 DOI: 10.4161/Chan.4.3.11386  0.669
2010 Zhang J, Ren C, Chen L, Navedo MF, Antos LK, Kinsey SP, Iwamoto T, Philipson KD, Kotlikoff MI, Santana LF, Wier WG, Matteson DR, Blaustein MP. Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure. American Journal of Physiology. Heart and Circulatory Physiology. 298: H1472-83. PMID 20173044 DOI: 10.1152/Ajpheart.00964.2009  0.519
2010 Ren C, Zhang J, Philipson KD, Kotlikoff MI, Blaustein MP, Matteson DR. Activation of L-type Ca2+ channels by protein kinase C is reduced in smooth muscle-specific Na+/Ca2+ exchanger knockout mice. American Journal of Physiology. Heart and Circulatory Physiology. 298: H1484-91. PMID 20081108 DOI: 10.1152/Ajpheart.00965.2009  0.459
2010 Wang J, Gao E, Song J, Zhang XQ, Li J, Koch WJ, Tucker AL, Philipson KD, Chan TO, Feldman AM, Cheung JY. Phospholemman and β-adrenergic stimulation in the heart American Journal of Physiology - Heart and Circulatory Physiology. 298: H807-H815. PMID 20008271 DOI: 10.1152/ajpheart.00877.2009  0.447
2009 Ottolia M, Nicoll DA, Philipson KD. Roles of two Ca2+-binding domains in regulation of the cardiac Na+-Ca2+ exchanger. The Journal of Biological Chemistry. 284: 32735-41. PMID 19801651 DOI: 10.1074/Jbc.M109.055434  0.652
2009 Chaptal V, Ottolia M, Mercado-Besserer G, Nicoll DA, Philipson KD, Abramson J. Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger. The Journal of Biological Chemistry. 284: 14688-92. PMID 19332552 DOI: 10.1074/Jbc.C900037200  0.651
2009 Blaustein MP, Zhang J, Chen L, Song H, Raina H, Kinsey SP, Izuka M, Iwamoto T, Kotlikoff MI, Lingrel JB, Philipson KD, Wier WG, Hamlyn JM. The pump, the exchanger, and endogenous ouabain: signaling mechanisms that link salt retention to hypertension. Hypertension. 53: 291-298. PMID 19104005 DOI: 10.1161/Hypertensionaha.108.119974  0.587
2008 Xie Y, Ottolia M, John SA, Chen JN, Philipson KD. Conformational changes of a Ca2+-binding domain of the Na+/Ca2+ exchanger monitored by FRET in transgenic zebrafish heart. American Journal of Physiology. Cell Physiology. 295: C388-93. PMID 18550703 DOI: 10.1152/Ajpcell.00178.2008  0.691
2008 Luo J, Wang Y, Chen H, Kintner DB, Cramer SW, Gerdts JK, Chen X, Shull GE, Philipson KD, Sun D. A concerted role of Na+ -K+ -Cl- cotransporter and Na+/Ca2+ exchanger in ischemic damage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 737-46. PMID 17912271 DOI: 10.1038/Sj.Jcbfm.9600561  0.428
2007 Chaptal V, Besserer GM, Ottolia M, Nicoll DA, Cascio D, Philipson KD, Abramson J. How does regulatory Ca2+ regulate the Na+-Ca2+ exchanger? Channels (Austin, Tex.). 1: 397-9. PMID 18690047 DOI: 10.4161/Chan.1.6.5640  0.685
2007 Besserer GM, Ottolia M, Nicoll DA, Chaptal V, Cascio D, Philipson KD, Abramson J. The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis. Proceedings of the National Academy of Sciences of the United States of America. 104: 18467-72. PMID 17962412 DOI: 10.1073/Pnas.0707417104  0.662
2007 Pott C, Goldhaber JI, Philipson KD. Homozygous overexpression of the Na+-Ca2+ exchanger in mice: evidence for increased transsarcolemmal Ca2+ fluxes. Annals of the New York Academy of Sciences. 1099: 310-4. PMID 17446472 DOI: 10.1196/annals.1387.019  0.665
2007 Luo J, Wang Y, Chen X, Chen H, Kintner DB, Shull GE, Philipson KD, Sun D. Increased tolerance to ischemic neuronal damage by knockdown of Na+-Ca2+ exchanger isoform 1. Annals of the New York Academy of Sciences. 1099: 292-305. PMID 17446470 DOI: 10.1196/Annals.1387.016  0.334
2007 Pott C, Henderson SA, Goldhaber JI, Philipson KD. Na+/Ca2+ exchanger knockout mice: plasticity of cardiac excitation-contraction coupling. Annals of the New York Academy of Sciences. 1099: 270-5. PMID 17446467 DOI: 10.1196/annals.1387.015  0.679
2007 Ottolia M, John S, Xie Y, Ren X, Philipson KD. Shedding light on the Na+/Ca2+ exchanger. Annals of the New York Academy of Sciences. 1099: 78-85. PMID 17446447 DOI: 10.1196/Annals.1387.044  0.647
2007 Cavalli A, Eghbali M, Minosyan TY, Stefani E, Philipson KD. Localization of sarcolemmal proteins to lipid rafts in the myocardium. Cell Calcium. 42: 313-22. PMID 17320949 DOI: 10.1016/J.Ceca.2007.01.003  0.415
2007 Nicoll DA, Ren X, Ottolia M, Phillips M, Paredes AR, Abramson J, Philipson KD. What we know about the structure of NCX1 and how it relates to its function. Annals of the New York Academy of Sciences. 1099: 1-6. PMID 17303833 DOI: 10.1196/Annals.1387.014  0.427
2007 Ottolia M, Philipson KD, John S. Xenopus oocyte plasma membrane sheets for FRET analysis. American Journal of Physiology. Cell Physiology. 292: C1519-22. PMID 17166939 DOI: 10.1152/Ajpcell.00435.2006  0.307
2007 Ottolia M, John S, Ren X, Philipson KD. Fluorescent Na+-Ca+ exchangers: electrophysiological and optical characterization. The Journal of Biological Chemistry. 282: 3695-701. PMID 17158867 DOI: 10.1074/Jbc.M610425200  0.596
2007 Pott C, Yip M, Goldhaber JI, Philipson KD. Regulation of cardiac L-type Ca2+ current in Na+-Ca2+ exchanger knockout mice: functional coupling of the Ca2+ channel and the Na+-Ca2+ exchanger. Biophysical Journal. 92: 1431-7. PMID 17114214 DOI: 10.1529/biophysj.106.091538  0.674
2007 Pott C, Ren X, Tran DX, Yang MJ, Henderson S, Jordan MC, Roos KP, Garfinkel A, Philipson KD, Goldhaber JI. Mechanism of shortened action potential duration in Na+-Ca2+ exchanger knockout mice. American Journal of Physiology. Cell Physiology. 292: C968-73. PMID 16943244 DOI: 10.1152/Ajpcell.00177.2006  0.61
2006 Nicoll DA, Sawaya MR, Kwon S, Cascio D, Philipson KD, Abramson J. The crystal structure of the primary Ca2+ sensor of the Na+/Ca2+ exchanger reveals a novel Ca2+ binding motif. The Journal of Biological Chemistry. 281: 21577-81. PMID 16774926 DOI: 10.1074/Jbc.C600117200  0.652
2005 Pott C, Philipson KD, Goldhaber JI. Excitation-contraction coupling in Na+-Ca2+ exchanger knockout mice: reduced transsarcolemmal Ca2+ flux. Circulation Research. 97: 1288-95. PMID 16293789 DOI: 10.1161/01.RES.0000196563.84231.21  0.647
2005 Imahashi K, Pott C, Goldhaber JI, Steenbergen C, Philipson KD, Murphy E. Cardiac-specific ablation of the Na+-Ca2+ exchanger confers protection against ischemia/reperfusion injury. Circulation Research. 97: 916-21. PMID 16179590 DOI: 10.1161/01.RES.0000187456.06162.cb  0.552
2005 Goldhaber JI, Henderson SA, Reuter H, Pott C, Philipson KD. Effects of Na+-Ca2+ exchange expression on excitation-contraction coupling in genetically modified mice. Annals of the New York Academy of Sciences. 1047: 122-6. PMID 16093490 DOI: 10.1196/annals.1341.011  0.319
2005 Reuter H, Pott C, Goldhaber JI, Henderson SA, Philipson KD, Schwinger RH. Na(+)--Ca2+ exchange in the regulation of cardiac excitation-contraction coupling. Cardiovascular Research. 67: 198-207. PMID 15935336 DOI: 10.1016/j.cardiores.2005.04.031  0.7
2005 Ottolia M, Nicoll DA, Philipson KD. Mutational analysis of the alpha-1 repeat of the cardiac Na(+)-Ca2+ exchanger. The Journal of Biological Chemistry. 280: 1061-9. PMID 15519995 DOI: 10.1074/Jbc.M411899200  0.456
2004 Pott C, Goldhaber JI, Philipson KD. Genetic manipulation of cardiac Na+/Ca2+ exchange expression. Biochemical and Biophysical Research Communications. 322: 1336-40. PMID 15336980 DOI: 10.1016/j.bbrc.2004.08.038  0.677
2004 Henderson SA, Goldhaber JI, So JM, Han T, Motter C, Ngo A, Chantawansri C, Ritter MR, Friedlander M, Nicoll DA, Frank JS, Jordan MC, Roos KP, Ross RS, Philipson KD. Functional adult myocardium in the absence of Na+-Ca2+ exchange: cardiac-specific knockout of NCX1. Circulation Research. 95: 604-11. PMID 15308581 DOI: 10.1161/01.Res.0000142316.08250.68  0.695
2004 Ottolia M, Philipson KD, John S. Conformational changes of the Ca(2+) regulatory site of the Na(+)-Ca(2+) exchanger detected by FRET. Biophysical Journal. 87: 899-906. PMID 15298897 DOI: 10.1529/Biophysj.104.043471  0.693
2004 Bouchard R, Omelchenko A, Le HD, Choptiany P, Matsuda T, Baba A, Takahashi K, Nicoll DA, Philipson KD, Hnatowich M, Hryshko LV. Effects of SEA0400 on mutant NCX1.1 Na+-Ca2+ exchangers with altered ionic regulation. Molecular Pharmacology. 65: 802-810. PMID 14978259 DOI: 10.1124/Mol.65.3.802  0.511
2004 Reuter H, Han T, Motter C, Philipson KD, Goldhaber JI. Mice overexpressing the cardiac sodium-calcium exchanger: defects in excitation-contraction coupling. The Journal of Physiology. 554: 779-89. PMID 14645454 DOI: 10.1113/jphysiol.2003.055046  0.667
2003 Jeon D, Yang YM, Jeong MJ, Philipson KD, Rhim H, Shin HS. Enhanced learning and memory in mice lacking Na+/Ca2+ exchanger 2 Neuron. 38: 965-976. PMID 12818181 DOI: 10.1016/S0896-6273(03)00334-9  0.579
2003 Reuter H, Henderson SA, Han T, Mottino GA, Frank JS, Ross RS, Goldhaber JI, Philipson KD. Cardiac excitation-contraction coupling in the absence of Na(+) - Ca2+ exchange. Cell Calcium. 34: 19-26. PMID 12767889  0.671
2003 Ritter M, Sui Z, Philipson KD, Li F, Spitzer KW, Ishida H, Barry WH. Ca2+ sparks induced by Na/Ca exchange. Cell Calcium. 34: 11-7. PMID 12767888  0.683
2003 Cho CH, Lee SY, Shin HS, Philipson KD, Lee CO. Partial rescue of the Na+-Ca2+ exchanger (NCX1) knock-out mouse by transgenic expression of NCX1. Experimental & Molecular Medicine. 35: 125-35. PMID 12754417 DOI: 10.1038/Emm.2003.18  0.345
2003 Min JY, Sullivan MF, Chu V, Wang JF, Amende I, Morgan JP, Philipson KD, Hampton TG. Overexpression of Na+/Ca2+ exchanger attenuates postinfarcted myocardial dysfunction. Annals of the New York Academy of Sciences. 976: 480-2. PMID 12502600 DOI: 10.1111/j.1749-6632.2002.tb04780.x  0.664
2002 Ottolia M, Schumann S, Nicoll DA, Philipson KD. Activation of the cardiac Na+/Ca2+ exchanger by DEPC. Annals of the New York Academy of Sciences. 976: 85-8. PMID 12502540 DOI: 10.1111/J.1749-6632.2002.Tb04720.X  0.657
2002 Philipson KD, Nicoll DA, Ottolia M, Quednau BD, Reuter H, John S, Qiu Z. The Na+/Ca2+ exchange molecule: an overview. Annals of the New York Academy of Sciences. 976: 1-10. PMID 12502528 DOI: 10.1111/J.1749-6632.2002.Tb04708.X  0.608
2002 McDonough AA, Velotta JB, Schwinger RH, Philipson KD, Farley RA. The cardiac sodium pump: structure and function. Basic Research in Cardiology. 97: I19-24. PMID 12479229  0.404
2002 Min JY, Sullivan MF, Yan X, Feng X, Chu V, Wang JF, Amende I, Morgan JP, Philipson KD, Hampton TG. Overexpression of Na+/Ca2+ exchanger gene attenuates postinfarction myocardial dysfunction. American Journal of Physiology. Heart and Circulatory Physiology. 283: H2466-71. PMID 12388257 DOI: 10.1152/ajpheart.01062.2001  0.543
2002 Reuter H, Henderson SA, Han T, Matsuda T, Baba A, Ross RS, Goldhaber JI, Philipson KD. Knockout mice for pharmacological screening: testing the specificity of Na+-Ca2+ exchange inhibitors. Circulation Research. 91: 90-2. PMID 12142340  0.651
2002 Reuter H, Henderson SA, Han T, Ross RS, Goldhaber JI, Philipson KD. The Na+-Ca2+ exchanger is essential for the action of cardiac glycosides. Circulation Research. 90: 305-8. PMID 11861419  0.701
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