| Year |
Citation |
Score |
| 2023 |
Frkic RL, Pederick JL, Horsfall AJ, Jovcevski B, Crame EE, Kowalczyk W, Pukala TL, Chang MR, Zheng J, Blayo AL, Abell AD, Kamenecka TM, Harbort JS, Harmer JR, Griffin PR, et al. PPARγ Corepression Involves Alternate Ligand Conformation and Inflation of H12 Ensembles. Acs Chemical Biology. PMID 37146157 DOI: 10.1021/acschembio.2c00917 |
0.35 |
|
| 2022 |
Watson ER, Novick S, Matyskiela ME, Chamberlain PP, H de la Peña A, Zhu J, Tran E, Griffin PR, Wertz IE, Lander GC. Molecular glue CELMoD compounds are regulators of cereblon conformation. Science (New York, N.Y.). 378: 549-553. PMID 36378961 DOI: 10.1126/science.add7574 |
0.3 |
|
| 2022 |
Cato ML, Cornelison JL, Spurlin RM, Courouble VV, Patel AB, Flynn AR, Johnson AM, Okafor CD, Frank F, D'Agostino EH, Griffin PR, Jui NT, Ortlund EA. Differential Modulation of Nuclear Receptor LRH-1 through Targeting Buried and Surface Regions of the Binding Pocket. Journal of Medicinal Chemistry. PMID 35503419 DOI: 10.1021/acs.jmedchem.2c00235 |
0.377 |
|
| 2021 |
Strutzenberg TS, Zhu Y, Novick SJ, Garcia-Ordonez RD, Doebelin C, He Y, Ra Chang M, Kamenecka TM, Edwards DP, Griffin PR. Conformational Changes of RORγ During Response Element Recognition and Coregulator Engagement. Journal of Molecular Biology. 167258. PMID 34547329 DOI: 10.1016/j.jmb.2021.167258 |
0.377 |
|
| 2021 |
Mosure SA, Strutzenberg TS, Shang J, Munoz-Tello P, Solt LA, Griffin PR, Kojetin DJ. Structural basis for heme-dependent NCoR binding to the transcriptional repressor REV-ERBβ. Science Advances. 7. PMID 33571111 DOI: 10.1126/sciadv.abc6479 |
0.347 |
|
| 2020 |
Shang J, Mosure SA, Zheng J, Brust R, Bass J, Nichols A, Solt LA, Griffin PR, Kojetin DJ. A molecular switch regulating transcriptional repression and activation of PPARγ. Nature Communications. 11: 956. PMID 32075969 DOI: 10.1038/s41467-020-14750-x |
0.365 |
|
| 2019 |
Heidari Z, Chrisman IM, Nemetchek MD, Novick SJ, Blayo AL, Patton T, Mendes DE, Diaz P, Kamenecka TM, Griffin PR, Hughes TS. Definition of functionally and structurally distinct repressive states in the nuclear receptor PPARγ. Nature Communications. 10: 5825. PMID 31862968 DOI: 10.1038/s41467-019-13768-0 |
0.415 |
|
| 2019 |
Shang J, Brust R, Griffin PR, Kamenecka TM, Kojetin DJ. Quantitative structural assessment of graded receptor agonism. Proceedings of the National Academy of Sciences of the United States of America. PMID 31611383 DOI: 10.1073/Pnas.1909016116 |
0.385 |
|
| 2019 |
Strutzenberg TS, Garcia-Ordonez RD, Novick SJ, Park H, Chang MR, Doebellin C, He Y, Patouret R, Kamenecka TM, Griffin PR. HDX-MS reveals structural determinants for RORγ hyperactivation by synthetic agonists. Elife. 8. PMID 31172947 DOI: 10.7554/eLife.47172 |
0.398 |
|
| 2019 |
Doebelin C, He Y, Campbell S, Nuhant P, Kumar N, Koenig M, Garcia-Ordonez R, Chang MR, Roush WR, Lin L, Kahn S, Cameron MD, Griffin PR, Solt LA, Kamenecka TM. Discovery and optimization of a series of sulfonamide inverse agonists for the retinoic acid receptor-related receptor-α. Medicinal Chemistry (Shariqah (United Arab Emirates)). PMID 30799793 DOI: 10.2174/1573406415666190222124745 |
0.311 |
|
| 2019 |
Mosure S, Shang J, Eberhardt J, Brust R, Zheng J, Griffin PR, Forli S, Kojetin DJ. Structural basis of altered potency and efficacy displayed by a major in vivo metabolite of the anti-diabetic PPARγ drug pioglitazone. Journal of Medicinal Chemistry. PMID 30676741 DOI: 10.1021/Acs.Jmedchem.8B01573 |
0.355 |
|
| 2018 |
Frkic RL, Chua BS, Shin Y, Pascal BD, Novick SJ, Kamenecka TM, Griffin PR, Bruning JB. Structural and Dynamic Elucidation of a Non-acid PPAR Partial Agonist: SR1988. Nuclear Receptor Research. 5. PMID 30906767 DOI: 10.11131/2018/101350 |
0.356 |
|
| 2018 |
de Vera IMS, Munoz-Tello P, Zheng J, Dharmarajan V, Marciano DP, Matta-Camacho E, Giri PK, Shang J, Hughes TS, Rance M, Griffin PR, Kojetin DJ. Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1. Structure (London, England : 1993). PMID 30416039 DOI: 10.1016/J.Str.2018.10.002 |
0.384 |
|
| 2018 |
Brust R, Shang J, Fuhrmann J, Mosure SA, Bass J, Cano A, Heidari Z, Chrisman IM, Nemetchek MD, Blayo AL, Griffin PR, Kamenecka TM, Hughes TS, Kojetin DJ. A structural mechanism for directing corepressor-selective inverse agonism of PPARγ. Nature Communications. 9: 4687. PMID 30409975 DOI: 10.1038/S41467-018-07133-W |
0.386 |
|
| 2018 |
Zheng J, Corzo C, Chang MR, Shang J, Lam VQ, Brust R, Blayo AL, Bruning JB, Kamenecka TM, Kojetin DJ, Griffin PR. Chemical Crosslinking Mass Spectrometry Reveals the Conformational Landscape of the Activation Helix of PPARγ; a Model for Ligand-Dependent Antagonism. Structure (London, England : 1993). PMID 30146169 DOI: 10.1016/J.Str.2018.07.007 |
0.38 |
|
| 2018 |
Frkic RL, Marshall AC, Blayo AL, Pukala TL, Kamenecka TM, Griffin PR, Bruning JB. PPARγ in Complex with an Antagonist and Inverse Agonist: a Tumble and Trap Mechanism of the Activation Helix. Iscience. 5: 69-79. PMID 30123887 DOI: 10.1016/j.isci.2018.06.012 |
0.414 |
|
| 2018 |
Bandyopadhyay A, Van Eps N, Eger BT, Rauscher S, Yedidi RS, Moroni T, West GM, Robinson KA, Griffin PR, Mitchell J, Ernst OP. A Novel Polar Core and Weakly Fixed C-Tail in Squid Arrestin Provide New Insight into Interaction with Rhodopsin. Journal of Molecular Biology. PMID 30120952 DOI: 10.1016/J.Jmb.2018.08.009 |
0.327 |
|
| 2018 |
Chrisman IM, Nemetchek MD, de Vera IMS, Shang J, Heidari Z, Long Y, Reyes-Caballero H, Galindo-Murillo R, Cheatham TE, Blayo AL, Shin Y, Fuhrmann J, Griffin PR, Kamenecka TM, Kojetin DJ, et al. Defining a conformational ensemble that directs activation of PPARγ. Nature Communications. 9: 1794. PMID 29728618 DOI: 10.1038/S41467-018-04176-X |
0.377 |
|
| 2018 |
Cherian MT, Chai SC, Wright WC, Singh A, Alexandra Casal M, Zheng J, Wu J, Lee RE, Griffin PR, Chen T. CINPA1 binds directly to constitutive androstane receptor and inhibits its activity. Biochemical Pharmacology. PMID 29608908 DOI: 10.1016/J.Bcp.2018.03.029 |
0.408 |
|
| 2017 |
Zheng J, Chang MR, Stites RE, Wang Y, Bruning JB, Pascal BD, Novick SJ, Garcia-Ordonez RD, Stayrook KR, Chalmers MJ, Dodge JA, Griffin PR. HDX reveals the conformational dynamics of DNA sequence specific VDR co-activator interactions. Nature Communications. 8: 923. PMID 29030554 DOI: 10.1038/S41467-017-00978-7 |
0.378 |
|
| 2017 |
Lam V, Zheng J, Griffin PR. Unique interactome network signatures for PPARγ modulation by functional selective ligands. Molecular & Cellular Proteomics : McP. PMID 28972081 DOI: 10.1074/mcp.RA117.000308 |
0.335 |
|
| 2017 |
Lin W, Wang YM, Chai SC, Lv L, Zheng J, Wu J, Zhang Q, Wang YD, Griffin PR, Chen T. SPA70 is a potent antagonist of human pregnane X receptor. Nature Communications. 8: 741. PMID 28963450 DOI: 10.1038/S41467-017-00780-5 |
0.344 |
|
| 2017 |
de Vera IMS, Zheng J, Novick S, Shang J, Hughes TS, Brust R, Munoz-Tello P, Gardner WJ, Marciano DP, Kong X, Griffin PR, Kojetin DJ. Synergistic Regulation of Coregulator/Nuclear Receptor Interaction by Ligand and DNA. Structure (London, England : 1993). PMID 28890360 DOI: 10.1016/J.Str.2017.07.019 |
0.4 |
|
| 2017 |
Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, ... ... Griffin PR, et al. Identification of Phosphorylation Codes for Arrestin Recruitment by G Protein-Coupled Receptors. Cell. 170: 457-469.e13. PMID 28753425 DOI: 10.1016/J.Cell.2017.07.002 |
0.303 |
|
| 2017 |
Zhang H, Qiao A, Yang D, Yang L, Dai A, de Graaf C, Reedtz-Runge S, Dharmarajan V, Zhang H, Han GW, Grant TD, Sierra RG, Weierstall U, Nelson G, Liu W, ... ... Griffin PR, et al. Structure of the full-length glucagon class B G-protein-coupled receptor. Nature. PMID 28514451 DOI: 10.1038/Nature22363 |
0.325 |
|
| 2017 |
Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, ... Griffin PR, et al. Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain. Nature Chemical Biology. 13: 691. PMID 28514419 DOI: 10.1038/nchembio0617-691b |
0.312 |
|
| 2017 |
Zhang X, Zhao F, Wu Y, Yang J, Han GW, Zhao S, Ishchenko A, Ye L, Lin X, Ding K, Dharmarajan V, Griffin PR, Gati C, Nelson G, Hunter MS, et al. Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand. Nature Communications. 8: 15383. PMID 28513578 DOI: 10.1038/Ncomms15383 |
0.31 |
|
| 2017 |
Mays SG, Okafor CD, Tuntland ML, Whitby RJ, Dharmarajan V, Stec J, Griffin PR, Ortlund EA. Structure and Dynamics of the Liver Receptor Homolog 1-PGC1α Complex. Molecular Pharmacology. PMID 28363985 DOI: 10.1124/Mol.117.108514 |
0.389 |
|
| 2016 |
Jin Z, Lin H, Srinivasan S, Nwachukwu JC, Bruno N, Griffin PR, Nettles KW, Kamenecka TM. Synthesis of novel steroidal agonists, partial agonists, and antagonists for the glucocorticoid receptor. Bioorganic & Medicinal Chemistry Letters. PMID 27919657 DOI: 10.1016/J.Bmcl.2016.11.007 |
0.342 |
|
| 2016 |
Doebelin C, Patouret R, Garcia-Ordonez RD, Chang MR, Dharmarajan V, Kuruvilla DS, Novick SJ, Lin L, Cameron MD, Griffin PR, Kamenecka TM. N-Arylsulfonyl Indolines as Retinoic Acid Receptor-Related Orphan Receptor γ (RORγ) Agonists. Chemmedchem. PMID 27879053 DOI: 10.1002/Cmdc.201600491 |
0.351 |
|
| 2016 |
Saltzberg DJ, Broughton HB, Pellarin R, Chalmers MJ, Espada A, Dodge JA, Pascal BD, Griffin PR, Humblet C, Sali A. A Residue Resolved Bayesian Approach to Quantitative Interpretation of Hydrogen Deuterium Exchange from Mass Spectrometry: Application to Characterizing Protein-Ligand Interactions. The Journal of Physical Chemistry. B. PMID 27807976 DOI: 10.1021/Acs.Jpcb.6B09358 |
0.309 |
|
| 2016 |
Mays SG, Okafor CD, Whitby RJ, Goswami D, Stec JO, Flynn AR, Dugan MC, Jui NT, Griffin PR, Ortlund EA. Crystal Structures of the Nuclear Receptor, Liver Receptor Homolog 1, Bound to Synthetic Agonists Reveal a Novel Mechanism of Activation. The Journal of Biological Chemistry. PMID 27694446 DOI: 10.1074/Jbc.M116.753541 |
0.448 |
|
| 2015 |
van Marrewijk LM, Polyak SW, Hijnen M, Kuruvilla D, Chang MR, Shin Y, Kamenecka TM, Griffin PR, Bruning JB. SR2067 reveals a unique kinetic and structural signature for PPARγ partial agonism. Acs Chemical Biology. PMID 26579553 DOI: 10.1021/acschembio.5b00580 |
0.321 |
|
| 2015 |
Marciano DP, Kuruvilla DS, Pascal BD, Griffin PR. Identification of Bexarotene as a PPARγ Antagonist with HDX. Ppar Research. 2015: 254560. PMID 26451138 DOI: 10.1155/2015/254560 |
0.39 |
|
| 2015 |
Mari Y, West GM, Scharager-Tapia C, Pascal BD, Garcia-Ordonez RD, Griffin PR. SERBP1 Is a Component of the Liver Receptor Homologue-1 Transcriptional Complex. Journal of Proteome Research. 14: 4571-80. PMID 26398198 DOI: 10.1021/Acs.Jproteome.5B00379 |
0.317 |
|
| 2015 |
Asteian A, Blayo AL, He Y, Koenig M, Shin Y, Kuruvilla DS, Corzo CA, Cameron MD, Lin L, Ruiz C, Khan S, Kumar N, Busby S, Marciano DP, Garcia-Ordonez RD, ... Griffin PR, et al. Design, Synthesis, and Biological Evaluation of Indole Biphenylcarboxylic Acids as PPARγ Antagonists. Acs Medicinal Chemistry Letters. 6: 998-1003. PMID 26396687 DOI: 10.1021/Acsmedchemlett.5B00218 |
0.68 |
|
| 2015 |
Kojetin DJ, Matta-Camacho E, Hughes TS, Srinivasan S, Nwachukwu JC, Cavett V, Nowak J, Chalmers MJ, Marciano DP, Kamenecka TM, Shulman AI, Rance M, Griffin PR, Bruning JB, Nettles KW. Structural mechanism for signal transduction in RXR nuclear receptor heterodimers. Nature Communications. 6: 8013. PMID 26289479 DOI: 10.1038/Ncomms9013 |
0.346 |
|
| 2015 |
Yang L, Yang D, de Graaf C, Moeller A, West GM, Dharmarajan V, Wang C, Siu FY, Song G, Reedtz-Runge S, Pascal BD, Wu B, Potter CS, Zhou H, Griffin PR, et al. Conformational states of the full-length glucagon receptor. Nature Communications. 6: 7859. PMID 26227798 DOI: 10.1038/Ncomms8859 |
0.338 |
|
| 2015 |
Corzo CA, Mari Y, Chang MR, Khan T, Kuruvilla D, Nuhant P, Kumar N, West GM, Duckett DR, Roush WR, Griffin PR. Antiproliferation activity of a small molecule repressor of liver receptor homolog 1. Molecular Pharmacology. 87: 296-304. PMID 25473120 DOI: 10.1124/Mol.114.095554 |
0.305 |
|
| 2014 |
West GM, Willard FS, Sloop KW, Showalter AD, Pascal BD, Griffin PR. Glucagon-like peptide-1 receptor ligand interactions: structural cross talk between ligands and the extracellular domain. Plos One. 9: e105683. PMID 25180755 DOI: 10.1371/Journal.Pone.0105683 |
0.33 |
|
| 2014 |
Carson MW, Zhang J, Chalmers MJ, Bocchinfuso WP, Holifield KD, Masquelin T, Stites RE, Stayrook KR, Griffin PR, Dodge JA. HDX reveals unique fragment ligands for the vitamin D receptor. Bioorganic & Medicinal Chemistry Letters. 24: 3459-63. PMID 24974344 DOI: 10.1016/j.bmcl.2014.05.070 |
0.372 |
|
| 2014 |
Goswami D, Callaway C, Pascal BD, Kumar R, Edwards DP, Griffin PR. Influence of domain interactions on conformational mobility of the progesterone receptor detected by hydrogen/deuterium exchange mass spectrometry. Structure (London, England : 1993). 22: 961-73. PMID 24909783 DOI: 10.1016/J.Str.2014.04.013 |
0.323 |
|
| 2014 |
Hughes TS, Giri PK, de Vera IM, Marciano DP, Kuruvilla DS, Shin Y, Blayo AL, Kamenecka TM, Burris TP, Griffin PR, Kojetin DJ. An alternate binding site for PPARγ ligands. Nature Communications. 5: 3571. PMID 24705063 DOI: 10.1038/Ncomms4571 |
0.358 |
|
| 2014 |
Boerma LJ, Xia G, Qui C, Cox BD, Chalmers MJ, Smith CD, Lobo-Ruppert S, Griffin PR, Muccio DD, Renfrow MB. Defining the communication between agonist and coactivator binding in the retinoid X receptor α ligand binding domain. The Journal of Biological Chemistry. 289: 814-26. PMID 24187139 DOI: 10.1074/Jbc.M113.476861 |
0.41 |
|
| 2013 |
Landgraf RR, Goswami D, Rajamohan F, Harris MS, Calabrese MF, Hoth LR, Magyar R, Pascal BD, Chalmers MJ, Busby SA, Kurumbail RG, Griffin PR. Activation of AMP-activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry. Structure (London, England : 1993). 21: 1942-53. PMID 24076403 DOI: 10.1016/J.Str.2013.08.023 |
0.678 |
|
| 2013 |
Kumar R, Moure CM, Khan SH, Callaway C, Grimm SL, Goswami D, Griffin PR, Edwards DP. Regulation of the structurally dynamic N-terminal domain of progesterone receptor by protein-induced folding. The Journal of Biological Chemistry. 288: 30285-99. PMID 23995840 DOI: 10.1074/Jbc.M113.491787 |
0.356 |
|
| 2013 |
Goswami D, Devarakonda S, Chalmers MJ, Pascal BD, Spiegelman BM, Griffin PR. Time window expansion for HDX analysis of an intrinsically disordered protein. Journal of the American Society For Mass Spectrometry. 24: 1584-92. PMID 23884631 DOI: 10.1007/s13361-013-0669-y |
0.357 |
|
| 2013 |
Musille PM, Pathak M, Lauer JL, Griffin PR, Ortlund EA. Divergent sequence tunes ligand sensitivity in phospholipid-regulated hormone receptors Journal of Biological Chemistry. 288: 20702-20712. PMID 23737522 DOI: 10.1074/Jbc.M113.472837 |
0.39 |
|
| 2013 |
Khan PM, El-Gendy Bel-D, Kumar N, Garcia-Ordonez R, Lin L, Ruiz CH, Cameron MD, Griffin PR, Kamenecka TM. Small molecule amides as potent ROR-γ selective modulators. Bioorganic & Medicinal Chemistry Letters. 23: 532-6. PMID 23232056 DOI: 10.1016/J.Bmcl.2012.11.025 |
0.307 |
|
| 2012 |
Chang MR, Goswami D, Mercer BA, Griffin PR. The therapeutic potential of RORγ modulators in the treatment of human disease. Journal of Experimental Pharmacology. 4: 141-8. PMID 27186126 DOI: 10.2147/JEP.S27078 |
0.394 |
|
| 2012 |
Khan SH, Awasthi S, Guo C, Goswami D, Ling J, Griffin PR, Simons SS, Kumar R. Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid receptor is accompanied by conformational reorganizations. The Journal of Biological Chemistry. 287: 44546-60. PMID 23132854 DOI: 10.1074/jbc.M112.411330 |
0.303 |
|
| 2012 |
Musille PM, Pathak MC, Lauer JL, Hudson WH, Griffin PR, Ortlund EA. Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation. Nature Structural & Molecular Biology. 19: 532-7, S1-2. PMID 22504882 DOI: 10.1038/Nsmb.2279 |
0.35 |
|
| 2012 |
Kumar N, Lyda B, Chang MR, Lauer JL, Solt LA, Burris TP, Kamenecka TM, Griffin PR. Identification of SR2211: a potent synthetic RORγ-selective modulator. Acs Chemical Biology. 7: 672-7. PMID 22292739 DOI: 10.1021/Cb200496Y |
0.331 |
|
| 2012 |
Burris TP, Busby SA, Griffin PR. Targeting orphan nuclear receptors for treatment of metabolic diseases and autoimmunity. Chemistry & Biology. 19: 51-9. PMID 22284354 DOI: 10.1016/J.Chembiol.2011.12.011 |
0.711 |
|
| 2012 |
Hughes TS, Chalmers MJ, Novick S, Kuruvilla DS, Chang MR, Kamenecka TM, Rance M, Johnson BA, Burris TP, Griffin PR, Kojetin DJ. Ligand and receptor dynamics contribute to the mechanism of graded PPARγ agonism. Structure (London, England : 1993). 20: 139-50. PMID 22244763 DOI: 10.1016/J.Str.2011.10.018 |
0.398 |
|
| 2012 |
Malapaka RR, Khoo S, Zhang J, Choi JH, Zhou XE, Xu Y, Gong Y, Li J, Yong EL, Chalmers MJ, Chang L, Resau JH, Griffin PR, Chen YE, Xu HE. Identification and mechanism of 10-carbon fatty acid as modulating ligand of peroxisome proliferator-activated receptors. The Journal of Biological Chemistry. 287: 183-95. PMID 22039047 DOI: 10.1074/Jbc.M111.294785 |
0.318 |
|
| 2011 |
Devarakonda S, Gupta K, Chalmers MJ, Hunt JF, Griffin PR, Van Duyne GD, Spiegelman BM. Disorder-to-order transition underlies the structural basis for the assembly of a transcriptionally active PGC-1α/ERRγ complex. Proceedings of the National Academy of Sciences of the United States of America. 108: 18678-83. PMID 22049338 DOI: 10.1073/Pnas.1113813108 |
0.327 |
|
| 2011 |
Choi JH, Banks AS, Kamenecka TM, Busby SA, Chalmers MJ, Kumar N, Kuruvilla DS, Shin Y, He Y, Bruning JB, Marciano DP, Cameron MD, Laznik D, Jurczak MJ, Schürer SC, ... ... Griffin PR, et al. Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation. Nature. 477: 477-81. PMID 21892191 DOI: 10.1038/Nature10383 |
0.689 |
|
| 2011 |
West GM, Chien EY, Katritch V, Gatchalian J, Chalmers MJ, Stevens RC, Griffin PR. Ligand-dependent perturbation of the conformational ensemble for the GPCR β2 adrenergic receptor revealed by HDX. Structure (London, England : 1993). 19: 1424-32. PMID 21889352 DOI: 10.1016/J.Str.2011.08.001 |
0.403 |
|
| 2011 |
Lee JM, Lee YK, Mamrosh JL, Busby SA, Griffin PR, Pathak MC, Ortlund EA, Moore DD. A nuclear-receptor-dependent phosphatidylcholine pathway with antidiabetic effects. Nature. 474: 506-10. PMID 21614002 DOI: 10.1038/Nature10111 |
0.68 |
|
| 2011 |
Chalmers MJ, Pascal BD, Willis S, Zhang J, Iturria SJ, Dodge JA, Griffin PR. Methods for the Analysis of High Precision Differential Hydrogen Deuterium Exchange Data. International Journal of Mass Spectrometry. 302: 59-68. PMID 21528013 DOI: 10.1016/j.ijms.2010.08.002 |
0.355 |
|
| 2011 |
Zhang J, Chalmers MJ, Stayrook KR, Burris LL, Wang Y, Busby SA, Pascal BD, Garcia-Ordonez RD, Bruning JB, Istrate MA, Kojetin DJ, Dodge JA, Burris TP, Griffin PR. DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex. Nature Structural & Molecular Biology. 18: 556-63. PMID 21478866 DOI: 10.1038/Nsmb.2046 |
0.716 |
|
| 2011 |
Willis S, Griffin PR. Mutual information identifies sequence positions conserved within the nuclear receptor superfamily: approach reveals functionally important regions for DNA binding specificity Nuclear Receptor Signaling. 9. PMID 21383938 DOI: 10.1621/nrs.09001 |
0.308 |
|
| 2011 |
Busby SA, Kumar N, Kuruvilla DS, Istrate MA, Conkright JJ, Wang Y, Kamenecka TM, Cameron MD, Roush WR, Burris TP, Griffin PR. Identification of a novel non-retinoid pan inverse agonist of the retinoic acid receptors. Acs Chemical Biology. 6: 618-27. PMID 21381756 DOI: 10.1021/Cb100396S |
0.728 |
|
| 2011 |
Chalmers MJ, Busby SA, Pascal BD, West GM, Griffin PR. Differential hydrogen/deuterium exchange mass spectrometry analysis of protein-ligand interactions. Expert Review of Proteomics. 8: 43-59. PMID 21329427 DOI: 10.1586/Epr.10.109 |
0.736 |
|
| 2011 |
Wright E, Busby SA, Wisecarver S, Vincent J, Griffin PR, Fernandez EJ. Helix 11 dynamics is critical for constitutive androstane receptor activity. Structure (London, England : 1993). 19: 37-44. PMID 21220114 DOI: 10.1016/j.str.2010.11.008 |
0.716 |
|
| 2011 |
Vidović D, Busby SA, Griffin PR, Schürer SC. A combined ligand- and structure-based virtual screening protocol identifies submicromolar PPARγ partial agonists. Chemmedchem. 6: 94-103. PMID 21162086 DOI: 10.1002/cmdc.201000428 |
0.696 |
|
| 2011 |
Kumar N, Kojetin DJ, Solt LA, Kumar KG, Nuhant P, Duckett DR, Cameron MD, Butler AA, Roush WR, Griffin PR, Burris TP. Identification of SR3335 (ML-176): a synthetic RORα selective inverse agonist. Acs Chemical Biology. 6: 218-22. PMID 21090593 DOI: 10.1021/Cb1002762 |
0.359 |
|
| 2010 |
Zhang J, Chalmers MJ, Stayrook KR, Burris LL, Garcia-Ordonez RD, Pascal BD, Burris TP, Dodge JA, Griffin PR. Hydrogen/deuterium exchange reveals distinct agonist/partial agonist receptor dynamics within vitamin D receptor/retinoid X receptor heterodimer. Structure (London, England : 1993). 18: 1332-41. PMID 20947021 DOI: 10.1016/J.Str.2010.07.007 |
0.417 |
|
| 2010 |
Wang Y, Kumar N, Nuhant P, Cameron MD, Istrate MA, Roush WR, Griffin PR, Burris TP. Identification of SR1078, a synthetic agonist for the orphan nuclear receptors RORα and RORγ. Acs Chemical Biology. 5: 1029-34. PMID 20735016 DOI: 10.1021/Cb100223D |
0.373 |
|
| 2010 |
Solt LA, Griffin PR, Burris TP. Ligand regulation of retinoic acid receptor-related orphan receptors: implications for development of novel therapeutics. Current Opinion in Lipidology. 21: 204-11. PMID 20463469 DOI: 10.1097/Mol.0B013E328338Ca18 |
0.359 |
|
| 2010 |
Kumar N, Solt LA, Wang Y, Rogers PM, Bhattacharyya G, Kamenecka TM, Stayrook KR, Crumbley C, Floyd ZE, Gimble JM, Griffin PR, Burris TP. Regulation of adipogenesis by natural and synthetic REV-ERB ligands. Endocrinology. 151: 3015-25. PMID 20427485 DOI: 10.1210/En.2009-0800 |
0.356 |
|
| 2010 |
Wang Y, Kumar N, Crumbley C, Griffin PR, Burris TP. A second class of nuclear receptors for oxysterols: Regulation of RORalpha and RORgamma activity by 24S-hydroxycholesterol (cerebrosterol). Biochimica Et Biophysica Acta. 1801: 917-23. PMID 20211758 DOI: 10.1016/J.Bbalip.2010.02.012 |
0.417 |
|
| 2010 |
Zhang X, Chien EY, Chalmers MJ, Pascal BD, Gatchalian J, Stevens RC, Griffin PR. Dynamics of the beta2-adrenergic G-protein coupled receptor revealed by hydrogen-deuterium exchange. Analytical Chemistry. 82: 1100-8. PMID 20058880 DOI: 10.1021/Ac902484P |
0.353 |
|
| 2010 |
Wang Y, Kumar N, Solt LA, Richardson TI, Helvering LM, Crumbley C, Garcia-Ordonez RD, Stayrook KR, Zhang X, Novick S, Chalmers MJ, Griffin PR, Burris TP. Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands. The Journal of Biological Chemistry. 285: 5013-25. PMID 19965867 DOI: 10.1074/Jbc.M109.080614 |
0.336 |
|
| 2010 |
Kumar N, Solt LA, Conkright JJ, Wang Y, Istrate MA, Busby SA, Garcia-Ordonez RD, Burris TP, Griffin PR. The benzenesulfoamide T0901317 [N-(2,2,2-trifluoroethyl)-N-[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]-benzenesulfonamide] is a novel retinoic acid receptor-related orphan receptor-alpha/gamma inverse agonist. Molecular Pharmacology. 77: 228-36. PMID 19887649 DOI: 10.1124/Mol.109.060905 |
0.709 |
|
| 2009 |
Dai SY, Burris TP, Dodge JA, Montrose-Rafizadeh C, Wang Y, Pascal BD, Chalmers MJ, Griffin PR. Unique ligand binding patterns between estrogen receptor alpha and beta revealed by hydrogen-deuterium exchange. Biochemistry. 48: 9668-76. PMID 19739677 DOI: 10.1021/Bi901149T |
0.337 |
|
| 2009 |
Avvaru BS, Busby SA, Chalmers MJ, Griffin PR, Venkatakrishnan B, Agbandje-McKenna M, Silverman DN, McKenna R. Apo-human carbonic anhydrase II revisited: implications of the loss of a metal in protein structure, stability, and solvent network. Biochemistry. 48: 7365-72. PMID 19583303 DOI: 10.1021/Bi9007512 |
0.64 |
|
| 2009 |
Lauer-Fields JL, Chalmers MJ, Busby SA, Minond D, Griffin PR, Fields GB. Identification of specific hemopexin-like domain residues that facilitate matrix metalloproteinase collagenolytic activity. The Journal of Biological Chemistry. 284: 24017-24. PMID 19574232 DOI: 10.1074/Jbc.M109.016873 |
0.636 |
|
| 2009 |
Pascal BD, Chalmers MJ, Busby SA, Griffin PR. HD desktop: an integrated platform for the analysis and visualization of H/D exchange data. Journal of the American Society For Mass Spectrometry. 20: 601-10. PMID 19135386 DOI: 10.1016/j.jasms.2008.11.019 |
0.625 |
|
| 2008 |
Dai SY, Chalmers MJ, Bruning J, Bramlett KS, Osborne HE, Montrose-Rafizadeh C, Barr RJ, Wang Y, Wang M, Burris TP, Dodge JA, Griffin PR. Prediction of the tissue-specificity of selective estrogen receptor modulators by using a single biochemical method Proceedings of the National Academy of Sciences of the United States of America. 105: 7171-7176. PMID 18474858 DOI: 10.1073/Pnas.0710802105 |
0.362 |
|
| 2007 |
Bruning JB, Chalmers MJ, Prasad S, Busby SA, Kamenecka TM, He Y, Nettles KW, Griffin PR. Partial agonists activate PPARgamma using a helix 12 independent mechanism. Structure (London, England : 1993). 15: 1258-71. PMID 17937915 DOI: 10.1016/J.Str.2007.07.014 |
0.709 |
|
| 2007 |
Chalmers MJ, Busby SA, Pascal BD, Southern MR, Griffin PR. A two-stage differential hydrogen deuterium exchange method for the rapid characterization of protein/ligand interactions. Journal of Biomolecular Techniques : Jbt. 18: 194-204. PMID 17916792 |
0.66 |
|
| 2006 |
Quint P, Ayala I, Busby SA, Chalmers MJ, Griffin PR, Rocca J, Nick HS, Silverman DN. Structural mobility in human manganese superoxide dismutase. Biochemistry. 45: 8209-15. PMID 16819819 DOI: 10.1021/Bi0606288 |
0.651 |
|
| 2006 |
Chalmers MJ, Busby SA, Pascal BD, He Y, Hendrickson CL, Marshall AG, Griffin PR. Probing protein ligand interactions by automated hydrogen/deuterium exchange mass spectrometry. Analytical Chemistry. 78: 1005-14. PMID 16478090 DOI: 10.1021/Ac051294F |
0.711 |
|
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