Duilio Cascio - Publications

Affiliations: 
1997-2015 UCLA-DOE Institute for Genomics  University of California, Los Angeles, Los Angeles, CA 

136 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Agdanowski MP, Castells-Graells R, Sawaya MR, Cascio D, Yeates TO, Arbing MA. X-ray crystal structure of a designed rigidified imaging scaffold in the ligand-free conformation. Acta Crystallographica. Section F, Structural Biology Communications. 80: 107-115. PMID 38767964 DOI: 10.1107/S2053230X2400414X  0.334
2023 Castells-Graells R, Meador K, Arbing MA, Sawaya MR, Gee M, Cascio D, Gleave E, Debreczeni JÉ, Breed J, Leopold K, Patel A, Jahagirdar D, Lyons B, Subramaniam S, Phillips C, et al. Cryo-EM structure determination of small therapeutic protein targets at 3 Å-resolution using a rigid imaging scaffold. Proceedings of the National Academy of Sciences of the United States of America. 120: e2305494120. PMID 37669364 DOI: 10.1073/pnas.2305494120  0.313
2022 Tetreau G, Sawaya MR, De Zitter E, Andreeva EA, Banneville AS, Schibrowsky NA, Coquelle N, Brewster AS, Grünbein ML, Kovacs GN, Hunter MS, Kloos M, Sierra RG, Schiro G, Qiao P, ... ... Cascio D, et al. De novo determination of mosquitocidal Cry11Aa and Cry11Ba structures from naturally-occurring nanocrystals. Nature Communications. 13: 4376. PMID 35902572 DOI: 10.1038/s41467-022-31746-x  0.314
2022 Mahoney BJ, Takayesu A, Zhou A, Cascio D, Clubb RT. The structure of the Clostridium thermocellum RsgI9 ectodomain provides insight into the mechanism of biomass sensing. Proteins. PMID 35194841 DOI: 10.1002/prot.26326  0.306
2020 Lu J, Cao Q, Hughes MP, Sawaya MR, Boyer DR, Cascio D, Eisenberg DS. CryoEM structure of the low-complexity domain of hnRNPA2 and its conversion to pathogenic amyloid. Nature Communications. 11: 4090. PMID 32796831 DOI: 10.1038/S41467-020-17905-Y  0.414
2020 Abskharon R, Seidler PM, Sawaya MR, Cascio D, Yang TP, Philipp S, Williams CK, Newell KL, Ghetti B, DeTure MA, Dickson DW, Vinters HV, Felgner PL, Nakajima R, Glabe CG, et al. Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. The Journal of Biological Chemistry. PMID 32493775 DOI: 10.1074/Jbc.Ra120.013638  0.312
2020 Tetreau G, Banneville AS, Andreeva EA, Brewster AS, Hunter MS, Sierra RG, Teulon JM, Young ID, Burke N, Grünewald TA, Beaudouin J, Snigireva I, Fernandez-Luna MT, Burt A, Park HW, ... ... Cascio D, et al. Serial femtosecond crystallography on in vivo-grown crystals drives elucidation of mosquitocidal Cyt1Aa bioactivation cascade. Nature Communications. 11: 1153. PMID 32123169 DOI: 10.1038/S41467-020-14894-W  0.374
2019 Hancock SP, Cascio D, Johnson RC. Cooperative DNA binding by proteins through DNA shape complementarity. Nucleic Acids Research. 47: 8874-8887. PMID 31616952 DOI: 10.1093/Nar/Gkz642  0.369
2019 Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. Structure based inhibitors of Amyloid Beta core suggest a common interface with Tau. Elife. 8. PMID 31612856 DOI: 10.7554/Elife.46924  0.313
2019 Jones CG, Asay M, Kim LJ, Kleinsasser JF, Saha A, Fulton TJ, Berkley KR, Cascio D, Malyutin AG, Conley MP, Stoltz BM, Lavallo V, Rodríguez JA, Nelson HM. Characterization of Reactive Organometallic Species via MicroED. Acs Central Science. 5: 1507-1513. PMID 31572777 DOI: 10.1021/Acscentsci.9B00403  0.313
2019 Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS. Author Correction: Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nature Structural & Molecular Biology. PMID 31530939 DOI: 10.1038/S41594-019-0316-9  0.303
2019 Warmack RA, Boyer DR, Zee CT, Richards LS, Sawaya MR, Cascio D, Gonen T, Eisenberg DS, Clarke SG. Structure of amyloid-β (20-34) with Alzheimer's-associated isomerization at Asp23 reveals a distinct protofilament interface. Nature Communications. 10: 3357. PMID 31350392 DOI: 10.1038/S41467-019-11183-Z  0.339
2019 Kattke MD, Gosschalk JE, Martinez OE, Kumar G, Gale RT, Cascio D, Sawaya MR, Philips M, Brown ED, Clubb RT. Structure and mechanism of TagA, a novel membrane-associated glycosyltransferase that produces wall teichoic acids in pathogenic bacteria. Plos Pathogens. 15: e1007723. PMID 31002736 DOI: 10.1371/Journal.Ppat.1007723  0.353
2019 Zee CT, Glynn C, Gallagher-Jones M, Miao J, Santiago CG, Cascio D, Gonen T, Sawaya MR, Rodriguez JA. Homochiral and racemic MicroED structures of a peptide repeat from the ice-nucleation protein InaZ. Iucrj. 6: 197-205. PMID 30867917 DOI: 10.1107/S2052252518017621  0.425
2019 Griner SL, Seidler P, Bowler J, Murray KA, Yang TP, Sahay S, Sawaya MR, Cascio D, Rodriguez JA, Philipp S, Sosna J, Glabe CG, Gonen T, Eisenberg DS. Author response: Structure-based inhibitors of amyloid beta core suggest a common interface with tau Elife. DOI: 10.7554/Elife.46924.036  0.309
2019 Abskharon R, Seidler P, Sawaya MR, Cascio D, Philipp S, Glabe CG, Eisenberg DS. ATOMIC STRUCTURES OF A SINGLE CHAIN ANTIBODY THAT BINDS AND INHIBITS SEEDING BY TAU OLIGOMERS Alzheimer's & Dementia. 15: P1599. DOI: 10.1016/J.Jalz.2019.09.061  0.316
2018 Yang Y, Eichhorn CD, Wang Y, Cascio D, Feigon J. Structural basis of 7SK RNA 5'-γ-phosphate methylation and retention by MePCE. Nature Chemical Biology. PMID 30559425 DOI: 10.1038/S41589-018-0188-Z  0.361
2018 Macdonald R, Cascio D, Collazo MJ, Phillips ML, Clubb RT. The Shr Protein Captures Human Hemoglobin Using Two Structurally Unique Binding Domains. The Journal of Biological Chemistry. PMID 30301765 DOI: 10.1074/Jbc.Ra118.005261  0.373
2018 Guenther EL, Cao Q, Trinh H, Lu J, Sawaya MR, Cascio D, Boyer DR, Rodriguez JA, Hughes MP, Eisenberg DS. Atomic structures of TDP-43 LCD segments and insights into reversible or pathogenic aggregation. Nature Structural & Molecular Biology. PMID 29786080 DOI: 10.1038/S41594-018-0064-2  0.383
2018 Thompson MC, Cascio D, Yeates TO. Microfocus diffraction from different regions of a protein crystal: structural variations and unit-cell polymorphism. Acta Crystallographica. Section D, Structural Biology. 74: 411-421. PMID 29717712 DOI: 10.1107/S2059798318003479  0.389
2018 Guenther EL, Ge P, Trinh H, Sawaya MR, Cascio D, Boyer DR, Gonen T, Zhou ZH, Eisenberg DS. Atomic-level evidence for packing and positional amyloid polymorphism by segment from TDP-43 RRM2. Nature Structural & Molecular Biology. PMID 29531287 DOI: 10.1038/S41594-018-0045-5  0.38
2018 Hughes MP, Sawaya MR, Boyer DR, Goldschmidt L, Rodriguez JA, Cascio D, Chong L, Gonen T, Eisenberg DS. Atomic structures of low-complexity protein segments reveal kinked β sheets that assemble networks. Science (New York, N.Y.). 359: 698-701. PMID 29439243 DOI: 10.1126/Science.Aan6398  0.404
2018 Gallagher-Jones M, Glynn C, Boyer DR, Martynowycz MW, Hernandez E, Miao J, Zee CT, Novikova IV, Goldschmidt L, McFarlane HT, Helguera GF, Evans JE, Sawaya MR, Cascio D, Eisenberg DS, et al. Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp. Nature Structural & Molecular Biology. PMID 29335561 DOI: 10.2210/Pdb6Axz/Pdb  0.363
2018 Seidler PM, Boyer DR, Rodriguez JA, Sawaya MR, Cascio D, Murray K, Gonen T, Eisenberg DS. Structure-based inhibitors of tau aggregation Nature Chemistry. 10: 170-176. DOI: 10.2210/Pdb5V5C/Pdb  0.318
2017 Rothé B, Leettola CN, Leal-Esteban L, Cascio D, Fortier S, Isenschmid M, Bowie JU, Constam DB. Crystal Structure of Bicc1 SAM Polymer and Mapping of Interactions between the Ciliopathy-Associated Proteins Bicc1, ANKS3, and ANKS6. Structure (London, England : 1993). PMID 29290488 DOI: 10.1016/J.Str.2017.12.002  0.409
2017 Krotee P, Griner SL, Sawaya MR, Cascio D, Rodriguez JA, Shi D, Philipp S, Murray K, Saelices L, Lee J, Seidler P, Glabe CG, Jiang L, Gonen T, Eisenberg DS. Common fibrillar spines of amyloid-β and human Islet Amyloid Polypeptide revealed by Micro Electron Diffraction and inhibitors developed using structure-based design. The Journal of Biological Chemistry. PMID 29282295 DOI: 10.1074/Jbc.M117.806109  0.333
2017 Popp D, Loh ND, Zorgati H, Ghoshdastider U, Liow LT, Ivanova MI, Larsson M, DePonte DP, Bean R, Beyerlein KR, Gati C, Oberthuer D, Arnlund D, Brändén G, Berntsen P, ... Cascio D, et al. Flow-aligned, single-shot fiber diffraction using a femtosecond X-ray free-electron laser. Cytoskeleton (Hoboken, N.J.). PMID 28574190 DOI: 10.1002/Cm.21378  0.339
2017 AhYoung AP, Lu B, Cascio D, Egea PF. Crystal structure of Mdm12 and combinatorial reconstitution of Mdm12/Mmm1 ERMES complexes for structural studies. Biochemical and Biophysical Research Communications. PMID 28479252 DOI: 10.1016/J.Bbrc.2017.05.021  0.468
2017 Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Philipp S, Griner S, Jiang L, Glabe CG, Westermark GT, Gonen T, et al. Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity. Elife. 6. PMID 28045370 DOI: 10.7554/Elife.19273  0.374
2017 Krotee P, Rodriguez JA, Sawaya MR, Cascio D, Reyes FE, Shi D, Hattne J, Nannenga BL, Oskarsson ME, Jiang L, Westermark GT, Gonen T, Eisenberg DS. The Cryo-EM Method Micro-ED Structure Determination of Type II Diabetes-Related Protein Segments Biophysical Journal. 112: 14a. DOI: 10.1016/J.Bpj.2016.11.110  0.301
2016 Kattke MD, Chan AH, Duong A, Sexton DL, Sawaya MR, Cascio D, Elliot MA, Clubb RT. Crystal Structure of the Streptomyces coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal. Plos One. 11: e0167763. PMID 27936128 DOI: 10.1371/Journal.Pone.0167763  0.359
2016 Bajaj RA, Arbing MA, Shin A, Cascio D, Miallau L. Crystal structure of the toxin Msmeg_6760, the structural homolog of Mycobacterium tuberculosis Rv2035, a novel type II toxin involved in the hypoxic response. Acta Crystallographica. Section F, Structural Biology Communications. 72: 863-869. PMID 27917833 DOI: 10.1107/S2053230X16017957  0.429
2016 Colletier JP, Sawaya MR, Gingery M, Rodriguez JA, Cascio D, Brewster AS, Michels-Clark T, Hice RH, Coquelle N, Boutet S, Williams GJ, Messerschmidt M, DePonte DP, Sierra RG, Laksmono H, et al. De novo phasing with X-ray laser reveals mosquito larvicide BinAB structure. Nature. PMID 27680699 DOI: 10.1038/Nature19825  0.398
2016 Bale JB, Gonen S, Liu Y, Sheffler W, Ellis D, Thomas C, Cascio D, Yeates TO, Gonen T, King NP, Baker D. Accurate design of megadalton-scale two-component icosahedral protein complexes. Science (New York, N.Y.). 353: 389-394. PMID 27463675 DOI: 10.1126/Science.Aaf8818  0.335
2016 Hancock SP, Stella S, Cascio D, Johnson RC. DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis. Plos One. 11: e0150189. PMID 26959646 DOI: 10.1371/Journal.Pone.0150189  0.316
2016 Taylor ND, Garruss AS, Moretti R, Chan S, Arbing MA, Cascio D, Rogers JK, Isaacs FJ, Kosuri S, Baker D, Fields S, Church GM, Raman S. Engineering an allosteric transcription factor to respond to new ligands. Nature Methods. 13: 177-83. PMID 26689263 DOI: 10.1038/Nmeth.3696  0.332
2015 AhYoung AP, Koehl A, Vizcarra CL, Cascio D, Egea PF. Structure of a putative ClpS N-end rule adaptor protein from the malaria pathogen Plasmodium falciparum. Protein Science : a Publication of the Protein Society. PMID 26701219 DOI: 10.1002/Pro.2868  0.374
2015 Noey EL, Tibrewal N, Jiménez-Osés G, Osuna S, Park J, Bond CM, Cascio D, Liang J, Zhang X, Huisman GW, Tang Y, Houk KN. Origins of stereoselectivity in evolved ketoreductases. Proceedings of the National Academy of Sciences of the United States of America. PMID 26644568 DOI: 10.1073/Pnas.1507910112  0.35
2015 Brumshtein B, Esswein SR, Salwinski L, Phillips ML, Ly AT, Cascio D, Sawaya MR, Eisenberg DS. Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain. Elife. 4. PMID 26576950 DOI: 10.7554/Elife.10935  0.304
2015 Jiang J, Chan H, Cash DD, Miracco EJ, Ogorzalek Loo RR, Upton HE, Cascio D, O'Brien Johnson R, Collins K, Loo JA, Zhou ZH, Feigon J. Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions. Science (New York, N.Y.). 350: aab4070. PMID 26472759 DOI: 10.1126/science.aab4070  0.302
2015 Rodriguez JA, Ivanova MI, Sawaya MR, Cascio D, Reyes FE, Shi D, Sangwan S, Guenther EL, Johnson LM, Zhang M, Jiang L, Arbing MA, Nannenga BL, Hattne J, Whitelegge J, et al. Structure of the toxic core of α-synuclein from invisible crystals. Nature. PMID 26352473 DOI: 10.1038/Nature15368  0.402
2015 Bale JB, Park RU, Liu Y, Gonen S, Gonen T, Cascio D, King NP, Yeates TO, Baker D. Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression. Protein Science : a Publication of the Protein Society. PMID 26174163 DOI: 10.1002/Pro.2748  0.357
2015 Winter JM, Cascio D, Dietrich D, Sato M, Watanabe K, Sawaya MR, Vederas JC, Tang Y. Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis. Journal of the American Chemical Society. PMID 26172141 DOI: 10.1021/Jacs.5B04520  0.395
2015 Thompson MC, Cascio D, Leibly DJ, Yeates TO. An allosteric model for control of pore opening by substrate binding in the EutL microcompartment shell protein. Protein Science : a Publication of the Protein Society. 24: 956-75. PMID 25752492 DOI: 10.1002/Pro.2672  0.425
2015 Soragni A, Yousefi S, Stoeckle C, Soriaga AB, Sawaya MR, Kozlowski E, Schmid I, Radonjic-Hoesli S, Boutet S, Williams GJ, Messerschmidt M, Seibert MM, Cascio D, Zatsepin NA, Burghammer M, et al. Toxicity of eosinophil MBP is repressed by intracellular crystallization and promoted by extracellular aggregation. Molecular Cell. 57: 1011-21. PMID 25728769 DOI: 10.1016/J.Molcel.2015.01.026  0.311
2015 Brewster AS, Sawaya MR, Rodriguez J, Hattne J, Echols N, McFarlane HT, Cascio D, Adams PD, Eisenberg DS, Sauter NK. Indexing amyloid peptide diffraction from serial femtosecond crystallography: new algorithms for sparse patterns. Acta Crystallographica. Section D, Biological Crystallography. 71: 357-66. PMID 25664747 DOI: 10.1107/S1399004714026145  0.32
2015 Singh M, Wang Z, Cascio D, Feigon J. Structure and interactions of the CS domain of human H/ACA RNP assembly protein Shq1. Journal of Molecular Biology. 427: 807-23. PMID 25553844 DOI: 10.1016/J.Jmb.2014.12.012  0.443
2015 Peng M, Cascio D, Egea PF. Crystal structure and solution characterization of the thioredoxin-2 from Plasmodium falciparum, a constituent of an essential parasitic protein export complex. Biochemical and Biophysical Research Communications. 456: 403-9. PMID 25475729 DOI: 10.1016/J.Bbrc.2014.11.096  0.301
2014 Bobik TA, Morales EJ, Shin A, Cascio D, Sawaya MR, Arbing M, Yeates TO, Rasche ME. Structure of the methanofuran/methanopterin-biosynthetic enzyme MJ1099 from Methanocaldococcus jannaschii. Acta Crystallographica. Section F, Structural Biology Communications. 70: 1472-9. PMID 25372812 DOI: 10.1107/S2053230X1402130X  0.336
2014 Balendiran GK, Pandian JR, Drake E, Vinayak A, Verma M, Cascio D. B-factor Analysis and Conformational Rearrangement of Aldose Reductase. Current Proteomics. 11: 151-160. PMID 25364319 DOI: 10.2174/157016461103140922163444  0.354
2014 Sawaya MR, Cascio D, Gingery M, Rodriguez J, Goldschmidt L, Colletier JP, Messerschmidt MM, Boutet S, Koglin JE, Williams GJ, Brewster AS, Nass K, Hattne J, Botha S, Doak RB, et al. Protein crystal structure obtained at 2.9 Å resolution from injecting bacterial cells into an X-ray free-electron laser beam. Proceedings of the National Academy of Sciences of the United States of America. 111: 12769-74. PMID 25136092 DOI: 10.1073/Pnas.1413456111  0.361
2014 Leettola CN, Knight MJ, Cascio D, Hoffman S, Bowie JU. Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3. Bmc Structural Biology. 14: 17. PMID 24998259 DOI: 10.1186/1472-6807-14-17  0.373
2014 Hochberg GK, Ecroyd H, Liu C, Cox D, Cascio D, Sawaya MR, Collier MP, Stroud J, Carver JA, Baldwin AJ, Robinson CV, Eisenberg DS, Benesch JL, Laganowsky A. The structured core domain of αB-crystallin can prevent amyloid fibrillation and associated toxicity. Proceedings of the National Academy of Sciences of the United States of America. 111: E1562-70. PMID 24711386 DOI: 10.1073/Pnas.1322673111  0.406
2014 Eisenberg D, Laganowsky A, Liu C, Sawaya M, Whitelegge J, Zhao M, Soriaga A, Landau M, Teng P, Cascio D, Jiang L, Sievers S, Soragni A. Structural Studies of the Amyloid State of Proteins Acta Crystallographica Section a Foundations and Advances. 70: C797-C797. DOI: 10.1107/S205327331409202X  0.397
2013 Arbing MA, Chan S, Harris L, Kuo E, Zhou TT, Ahn CJ, Nguyen L, He Q, Lu J, Menchavez PT, Shin A, Holton T, Sawaya MR, Cascio D, Eisenberg D. Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions. Plos One. 8: e81753. PMID 24312350 DOI: 10.1371/Journal.Pone.0081753  0.382
2013 Toledo Warshaviak D, Khramtsov VV, Cascio D, Altenbach C, Hubbell WL. Structure and dynamics of an imidazoline nitroxide side chain with strongly hindered internal motion in proteins. Journal of Magnetic Resonance (San Diego, Calif. : 1997). 232: 53-61. PMID 23694751 DOI: 10.1016/J.Jmr.2013.04.013  0.403
2013 Sheng Y, Durazo A, Schumacher M, Gralla EB, Cascio D, Cabelli DE, Valentine JS. Tetramerization reinforces the dimer interface of MnSOD. Plos One. 8: e62446. PMID 23667478 DOI: 10.1371/Journal.Pone.0062446  0.352
2013 Hancock SP, Ghane T, Cascio D, Rohs R, Di Felice R, Johnson RC. Control of DNA minor groove width and Fis protein binding by the purine 2-amino group. Nucleic Acids Research. 41: 6750-60. PMID 23661683 DOI: 10.1093/Nar/Gkt357  0.357
2013 Miallau L, Jain P, Arbing MA, Cascio D, Phan T, Ahn CJ, Chan S, Chernishof I, Maxson M, Chiang J, Jacobs WR, Eisenberg DS. Comparative proteomics identifies the cell-associated lethality of M. tuberculosis RelBE-like toxin-antitoxin complexes. Structure (London, England : 1993). 21: 627-37. PMID 23523424 DOI: 10.1016/J.Str.2013.02.008  0.402
2013 Wheatley NM, Gidaniyan SD, Liu Y, Cascio D, Yeates TO. Bacterial microcompartment shells of diverse functional types possess pentameric vertex proteins. Protein Science : a Publication of the Protein Society. 22: 660-5. PMID 23456886 DOI: 10.1002/Pro.2246  0.436
2012 Min AB, Miallau L, Sawaya MR, Habel J, Cascio D, Eisenberg D. The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg²⁺ ion in the active site and a putative RNA-binding site. Protein Science : a Publication of the Protein Society. 21: 1754-67. PMID 23011806 DOI: 10.1002/Pro.2161  0.306
2012 Gorynia S, Lorenz TC, Costaguta G, Daboussi L, Cascio D, Payne GS. Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins. Molecular Biology of the Cell. 23: 4416-29. PMID 22993212 DOI: 10.1091/Mbc.E12-07-0507  0.372
2012 Singh M, Wang Z, Koo BK, Patel A, Cascio D, Collins K, Feigon J. Structural basis for telomerase RNA recognition and RNP assembly by the holoenzyme La family protein p65. Molecular Cell. 47: 16-26. PMID 22705372 DOI: 10.1016/J.Molcel.2012.05.018  0.372
2012 Lai YT, Cascio D, Yeates TO. Structure of a 16-nm cage designed by using protein oligomers. Science (New York, N.Y.). 336: 1129. PMID 22654051 DOI: 10.1126/Science.1219351  0.415
2012 Laganowsky A, Liu C, Sawaya MR, Whitelegge JP, Park J, Zhao M, Pensalfini A, Soriaga AB, Landau M, Teng PK, Cascio D, Glabe C, Eisenberg D. Atomic view of a toxic amyloid small oligomer. Science (New York, N.Y.). 335: 1228-31. PMID 22403391 DOI: 10.1126/Science.1213151  0.4
2011 Colletier JP, Laganowsky A, Landau M, Zhao M, Soriaga AB, Goldschmidt L, Flot D, Cascio D, Sawaya MR, Eisenberg D. Molecular basis for amyloid-beta polymorphism. Proceedings of the National Academy of Sciences of the United States of America. 108: 16938-43. PMID 21949245 DOI: 10.1073/Pnas.1112600108  0.369
2011 Fleissner MR, Bridges MD, Brooks EK, Cascio D, Kálai T, Hideg K, Hubbell WL. Structure and dynamics of a conformationally constrained nitroxide side chain and applications in EPR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 108: 16241-6. PMID 21911399 DOI: 10.1073/Pnas.1111420108  0.353
2011 Laganowsky A, Zhao M, Soriaga AB, Sawaya MR, Cascio D, Yeates TO. An approach to crystallizing proteins by metal-mediated synthetic symmetrization. Protein Science : a Publication of the Protein Society. 20: 1876-90. PMID 21898649 DOI: 10.1002/Pro.727  0.392
2011 Zhao M, Cascio D, Sawaya MR, Eisenberg D. Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation. Protein Science : a Publication of the Protein Society. 20: 996-1004. PMID 21462277 DOI: 10.1002/Pro.630  0.424
2011 Apostol MI, Wiltzius JJ, Sawaya MR, Cascio D, Eisenberg D. Atomic structures suggest determinants of transmission barriers in mammalian prion disease. Biochemistry. 50: 2456-63. PMID 21323366 DOI: 10.1021/Bi101803K  0.328
2011 Balendiran GK, Sawaya MR, Schwarz FP, Ponniah G, Cuckovich R, Verma M, Cascio D. The role of Cys-298 in aldose reductase function. The Journal of Biological Chemistry. 286: 6336-44. PMID 21084309 DOI: 10.1074/Jbc.M110.154195  0.34
2011 Forse GJ, Ram N, Banatao DR, Cascio D, Sawaya MR, Klock HE, Lesley SA, Yeates TO. Synthetic symmetrization in the crystallization and structure determination of CelA from Thermotoga maritima. Protein Science : a Publication of the Protein Society. 20: 168-78. PMID 21082721 DOI: 10.1002/Pro.550  0.44
2011 Yeates T, Thompson M, Sheng F, Kopstein J, Sawaya M, Cascio D, Crowley C. Structure and function of protein-based metabolic organelles in bacteria Acta Crystallographica Section a Foundations of Crystallography. 67: C36-C36. DOI: 10.1107/S010876731109920X  0.341
2010 Crowley CS, Cascio D, Sawaya MR, Kopstein JS, Bobik TA, Yeates TO. Structural insight into the mechanisms of transport across the Salmonella enterica Pdu microcompartment shell. The Journal of Biological Chemistry. 285: 37838-46. PMID 20870711 DOI: 10.1074/Jbc.M110.160580  0.418
2010 Apostol MI, Sawaya MR, Cascio D, Eisenberg D. Crystallographic studies of prion protein (PrP) segments suggest how structural changes encoded by polymorphism at residue 129 modulate susceptibility to human prion disease. The Journal of Biological Chemistry. 285: 29671-5. PMID 20685658 DOI: 10.1074/Jbc.C110.158303  0.406
2010 Arbing MA, Kaufmann M, Phan T, Chan S, Cascio D, Eisenberg D. The crystal structure of the Mycobacterium tuberculosis Rv3019c-Rv3020c ESX complex reveals a domain-swapped heterotetramer. Protein Science : a Publication of the Protein Society. 19: 1692-703. PMID 20629176 DOI: 10.1002/Pro.451  0.401
2010 Senturia R, Faller M, Yin S, Loo JA, Cascio D, Sawaya MR, Hwang D, Clubb RT, Guo F. Structure of the dimerization domain of DiGeorge critical region 8. Protein Science : a Publication of the Protein Society. 19: 1354-65. PMID 20506313 DOI: 10.1002/Pro.414  0.34
2010 Laganowsky A, Benesch JL, Landau M, Ding L, Sawaya MR, Cascio D, Huang Q, Robinson CV, Horwitz J, Eisenberg D. Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function. Protein Science : a Publication of the Protein Society. 19: 1031-43. PMID 20440841 DOI: 10.1002/Pro.380  0.452
2010 Stella S, Cascio D, Johnson RC. The shape of the DNA minor groove directs binding by the DNA-bending protein Fis. Genes & Development. 24: 814-26. PMID 20395367 DOI: 10.1101/Gad.1900610  0.352
2010 Di Pietro SM, Cascio D, Feliciano D, Bowie JU, Payne GS. Regulation of clathrin adaptor function in endocytosis: novel role for the SAM domain. The Embo Journal. 29: 1033-44. PMID 20150898 DOI: 10.1038/Emboj.2010.5  0.366
2009 Fleissner MR, Brustad EM, Kálai T, Altenbach C, Cascio D, Peters FB, Hideg K, Peuker S, Schultz PG, Hubbell WL. Site-directed spin labeling of a genetically encoded unnatural amino acid. Proceedings of the National Academy of Sciences of the United States of America. 106: 21637-42. PMID 19995976 DOI: 10.1073/Pnas.0912009106  0.317
2009 Wiltzius JJ, Landau M, Nelson R, Sawaya MR, Apostol MI, Goldschmidt L, Soriaga AB, Cascio D, Rajashankar K, Eisenberg D. Molecular mechanisms for protein-encoded inheritance. Nature Structural & Molecular Biology. 16: 973-8. PMID 19684598 DOI: 10.1038/Nsmb.1643  0.349
2009 Ujwal R, Cascio D, Chaptal V, Ping P, Abramson J. Crystal packing analysis of murine VDAC1 crystals in a lipidic environment reveals novel insights on oligomerization and orientation. Channels (Austin, Tex.). 3: 167-70. PMID 19574737 DOI: 10.4161/Chan.3.3.9196  0.428
2009 Fleissner MR, Cascio D, Hubbell WL. Structural origin of weakly ordered nitroxide motion in spin-labeled proteins. Protein Science : a Publication of the Protein Society. 18: 893-908. PMID 19384990 DOI: 10.1002/Pro.96  0.316
2009 Singh M, Gonzales FA, Cascio D, Heckmann N, Chanfreau G, Feigon J. Structure and functional studies of the CS domain of the essential H/ACA ribonucleoparticle assembly protein SHQ1. The Journal of Biological Chemistry. 284: 1906-16. PMID 19019820 DOI: 10.1074/Jbc.M807337200  0.354
2009 Miallau L, Faller M, Chiang J, Arbing M, Guo F, Cascio D, Eisenberg D. Structure and proposed activity of a member of the VapBC family of toxin-antitoxin systems. VapBC-5 from Mycobacterium tuberculosis. The Journal of Biological Chemistry. 284: 276-83. PMID 18952600 DOI: 10.1074/Jbc.M805061200  0.394
2008 Ujwal R, Cascio D, Colletier JP, Faham S, Zhang J, Toro L, Ping P, Abramson J. The crystal structure of mouse VDAC1 at 2.3 A resolution reveals mechanistic insights into metabolite gating. Proceedings of the National Academy of Sciences of the United States of America. 105: 17742-7. PMID 18988731 DOI: 10.1073/Pnas.0809634105  0.393
2008 Faham S, Watanabe A, Besserer GM, Cascio D, Specht A, Hirayama BA, Wright EM, Abramson J. The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport. Science (New York, N.Y.). 321: 810-4. PMID 18599740 DOI: 10.1126/Science.1160406  0.39
2008 King NP, Lee TM, Sawaya MR, Cascio D, Yeates TO. Structures and functional implications of an AMP-binding cystathionine beta-synthase domain protein from a hyperthermophilic archaeon. Journal of Molecular Biology. 380: 181-92. PMID 18513746 DOI: 10.1016/J.Jmb.2008.04.073  0.436
2008 Guo Z, Cascio D, Hideg K, Hubbell WL. Structural determinants of nitroxide motion in spin-labeled proteins: solvent-exposed sites in helix B of T4 lysozyme. Protein Science : a Publication of the Protein Society. 17: 228-39. PMID 18096642 DOI: 10.1110/Ps.073174008  0.357
2008 Bajaj SP, Sutton A, Shanker S, Schmidt AE, Agah S, Velander WH, Padmanabhan K, Cascio D. Structural and Functional Investigations of Active Site Binding Regions in Factor VIIa. Blood. 112: 2029-2029. DOI: 10.1182/Blood.V112.11.2029.2029  0.321
2007 Boutz DR, Cascio D, Whitelegge J, Perry LJ, Yeates TO. Discovery of a thermophilic protein complex stabilized by topologically interlinked chains. Journal of Molecular Biology. 368: 1332-44. PMID 17395198 DOI: 10.1016/J.Jmb.2007.02.078  0.405
2007 Abbani MA, Papagiannis CV, Sam MD, Cascio D, Johnson RC, Clubb RT. Structure of the cooperative Xis-DNA complex reveals a micronucleoprotein filament that regulates phage lambda intasome assembly. Proceedings of the National Academy of Sciences of the United States of America. 104: 2109-14. PMID 17287355 DOI: 10.1073/Pnas.0607820104  0.379
2007 Papagiannis CV, Sam MD, Abbani MA, Yoo D, Cascio D, Clubb RT, Johnson RC. Fis targets assembly of the Xis nucleoprotein filament to promote excisive recombination by phage lambda. Journal of Molecular Biology. 367: 328-43. PMID 17275024 DOI: 10.1016/J.Jmb.2006.12.071  0.391
2006 Banatao DR, Cascio D, Crowley CS, Fleissner MR, Tienson HL, Yeates TO. An approach to crystallizing proteins by synthetic symmetrization. Proceedings of the National Academy of Sciences of the United States of America. 103: 16230-5. PMID 17050682 DOI: 10.1073/Pnas.0607674103  0.411
2006 Sam MD, Abbani MA, Cascio D, Johnson RC, Clubb RT. Crystallization, dehydration and preliminary X-ray analysis of excisionase (Xis) proteins cooperatively bound to DNA. Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. 62: 825-8. PMID 16880568 DOI: 10.1107/S1744309106027643  0.377
2006 Strong M, Sawaya MR, Wang S, Phillips M, Cascio D, Eisenberg D. Toward the structural genomics of complexes: crystal structure of a PE/PPE protein complex from Mycobacterium tuberculosis. Proceedings of the National Academy of Sciences of the United States of America. 103: 8060-5. PMID 16690741 DOI: 10.1073/Pnas.0602606103  0.404
2005 Kim CA, Sawaya MR, Cascio D, Kim W, Bowie JU. Structural organization of a Sex-comb-on-midleg/polyhomeotic copolymer. The Journal of Biological Chemistry. 280: 27769-75. PMID 15905166 DOI: 10.1074/Jbc.M503055200  0.364
2005 Johnson E, Cascio D, Sawaya MR, Gingery M, Schröder I. Crystal structures of a tetrahedral open pore ferritin from the hyperthermophilic archaeon Archaeoglobus fulgidus. Structure (London, England : 1993). 13: 637-48. PMID 15837202 DOI: 10.1016/J.Str.2005.01.019  0.398
2004 Chan S, Segelke B, Lekin T, Krupka H, Cho US, Kim MY, So M, Kim CY, Naranjo CM, Rogers YC, Park MS, Waldo GS, Pashkov I, Cascio D, Perry JL, et al. Crystal structure of the Mycobacterium tuberculosis dUTPase: insights into the catalytic mechanism. Journal of Molecular Biology. 341: 503-17. PMID 15276840 DOI: 10.1016/J.Jmb.2004.06.028  0.377
2004 Sam MD, Cascio D, Johnson RC, Clubb RT. Crystal structure of the excisionase-DNA complex from bacteriophage lambda. Journal of Molecular Biology. 338: 229-40. PMID 15066428 DOI: 10.1016/J.Jmb.2004.02.053  0.416
2003 Goulding CW, Perry LJ, Anderson D, Sawaya MR, Cascio D, Apostol MI, Chan S, Parseghian A, Wang SS, Wu Y, Cassano V, Gill HS, Eisenberg D. Structural genomics of Mycobacterium tuberculosis: a preliminary report of progress at UCLA. Biophysical Chemistry. 105: 361-70. PMID 14499904 DOI: 10.1016/S0301-4622(03)00101-7  0.376
2003 Kerfeld CA, Sawaya MR, Bottin H, Tran KT, Sugiura M, Cascio D, Desbois A, Yeates TO, Kirilovsky D, Boussac A. Structural and EPR characterization of the soluble form of cytochrome c-550 and of the psbV2 gene product from the cyanobacterium Thermosynechococcus elongatus. Plant & Cell Physiology. 44: 697-706. PMID 12881497 DOI: 10.1093/Pcp/Pcg084  0.35
2003 Sam MD, Cascio D, Johnson R, Clubb RT. Crystallization and preliminary X-ray crystallographic analysis of the excisionase-DNA complex from bacteriophage lambda. Acta Crystallographica. Section D, Biological Crystallography. 59: 1238-40. PMID 12832771 DOI: 10.1107/S0907444903008606  0.421
2003 Kerfeld CA, Yoshida S, Tran KT, Yeates TO, Cascio D, Bottin H, Berthomieu C, Sugiura M, Boussac A. The 1.6 A resolution structure of Fe-superoxide dismutase from the thermophilic cyanobacterium Thermosynechococcus elongatus. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. 8: 707-14. PMID 12827458 DOI: 10.1007/S00775-003-0469-0  0.348
2003 Kerfeld CA, Sawaya MR, Brahmandam V, Cascio D, Ho KK, Trevithick-Sutton CC, Krogmann DW, Yeates TO. The crystal structure of a cyanobacterial water-soluble carotenoid binding protein. Structure (London, England : 1993). 11: 55-65. PMID 12517340 DOI: 10.1016/S0969-2126(02)00936-X  0.418
2003 Anderson DH, Sawaya MR, Cascio D, Ernst W, Modlin R, Krensky A, Eisenberg D. Granulysin crystal structure and a structure-derived lytic mechanism. Journal of Molecular Biology. 325: 355-65. PMID 12488100 DOI: 10.1016/S0022-2836(02)01234-2  0.385
2002 Goulding CW, Parseghian A, Sawaya MR, Cascio D, Apostol MI, Gennaro ML, Eisenberg D. Crystal structure of a major secreted protein of Mycobacterium tuberculosis-MPT63 at 1.5-A resolution. Protein Science : a Publication of the Protein Society. 11: 2887-93. PMID 12441386 DOI: 10.1110/Ps.0219002  0.424
2002 Wang S, Mura C, Sawaya MR, Cascio D, Eisenberg D. Structure of a Nudix protein from Pyrobaculum aerophilum reveals a dimer with two intersubunit beta-sheets. Acta Crystallographica. Section D, Biological Crystallography. 58: 571-8. PMID 11914479 DOI: 10.1107/S0907444902001191  0.62
2001 Fahrner RL, Cascio D, Lake JA, Slesarev A. An ancestral nuclear protein assembly: crystal structure of the Methanopyrus kandleri histone. Protein Science : a Publication of the Protein Society. 10: 2002-7. PMID 11567091 DOI: 10.1110/Ps.10901  0.349
2001 Mura C, Cascio D, Sawaya MR, Eisenberg DS. The crystal structure of a heptameric archaeal Sm protein: Implications for the eukaryotic snRNP core. Proceedings of the National Academy of Sciences of the United States of America. 98: 5532-7. PMID 11331747 DOI: 10.1073/Pnas.091102298  0.644
2000 Langen R, Oh KJ, Cascio D, Hubbell WL. Crystal structures of spin labeled T4 lysozyme mutants: implications for the interpretation of EPR spectra in terms of structure. Biochemistry. 39: 8396-405. PMID 10913245 DOI: 10.1021/Bi000604F  0.373
1999 Thanos CD, Faham S, Goodwill KE, Cascio D, Phillips M, Bowie JU. Monomeric structure of the human EphB2 sterile alpha motif domain. The Journal of Biological Chemistry. 274: 37301-6. PMID 10601296 DOI: 10.1074/Jbc.274.52.37301  0.401
1999 Patterson WR, Anderson DH, DeGrado WF, Cascio D, Eisenberg D. Centrosymmetric bilayers in the 0.75 A resolution structure of a designed alpha-helical peptide, D,L-Alpha-1. Protein Science : a Publication of the Protein Society. 8: 1410-22. PMID 10422829 DOI: 10.1110/Ps.8.7.1410  0.316
1999 Privé GG, Anderson DH, Wesson L, Cascio D, Eisenberg D. Packed protein bilayers in the 0.90 A resolution structure of a designed alpha helical bundle. Protein Science : a Publication of the Protein Society. 8: 1400-9. PMID 10422828 DOI: 10.1110/Ps.8.7.1400  0.371
1998 Colovos C, Cascio D, Yeates TO. The 1.8 A crystal structure of the ycaC gene product from Escherichia coli reveals an octameric hydrolase of unknown specificity. Structure (London, England : 1993). 6: 1329-37. PMID 9782055 DOI: 10.1016/S0969-2126(98)00132-4  0.429
1998 Baikalov I, Schröder I, Kaczor-Grzeskowiak M, Cascio D, Gunsalus RP, Dickerson RE. NarL dimerization? Suggestive evidence from a new crystal form. Biochemistry. 37: 3665-76. PMID 9521685 DOI: 10.1021/Bi972365A  0.426
1997 Han GW, Kopka ML, Cascio D, Grzeskowiak K, Dickerson RE. Structure of a DNA analog of the primer for HIV-1 RT second strand synthesis. Journal of Molecular Biology. 269: 811-26. PMID 9223643 DOI: 10.1006/Jmbi.1997.1085  0.303
1994 McKenna MC, Anderson D, Cascio D, Eisenberg D. Crystallization studies of the human immunodeficiency virus (HIV-1) Tat protein and its trans-activation response element (TAR) RNA. Acta Crystallographica. Section D, Biological Crystallography. 50: 527-34. PMID 15299414 DOI: 10.1107/S0907444994001289  0.33
1994 Zhang KYJ, Cascio D, Eisenberg D. Crystal structure of the unactivated ribulose 1,5-bisphosphate carboxylase/oxygenase complexed with a transition state analog, 2-carboxy-D- arabinitol 1,5-bisphosphate Protein Science. 3: 64-69. PMID 8142899 DOI: 10.1002/Pro.5560030109  0.373
1994 Kopka ML, Goodsell DS, Baikalov I, Grzeskowiak K, Cascio D, Dickerson RE. Crystal structure of a covalent DNA-drug adduct: anthramycin bound to C-C-A-A-C-G-T-T-G-G and a molecular explanation of specificity. Biochemistry. 33: 13593-610. PMID 7947769 DOI: 10.1021/Bi00250A011  0.327
1993 Goodsell DS, Kopka ML, Cascio D, Dickerson RE. Crystal structure of CATGGCCATG and its implications for A-tract bending models Proceedings of the National Academy of Sciences of the United States of America. 90: 2930-2934. PMID 8464909 DOI: 10.1073/Pnas.90.7.2930  0.351
1993 Lovejoy B, Choe S, Cascio D, McRorie DK, DeGrado WF, Eisenberg D. Crystal structure of a synthetic triple-stranded alpha-helical bundle. Science (New York, N.Y.). 259: 1288-93. PMID 8446897 DOI: 10.1126/Science.8446897  0.384
1993 Redinbo MR, Cascio D, Choukair MK, Rice D, Merchant S, Yeates TO. The 1.5-A crystal structure of plastocyanin from the green alga Chlamydomonas reinhardtii. Biochemistry. 32: 10560-7. PMID 8399201 DOI: 10.1021/Bi00091A005  0.386
1993 Schreuder HA, Knight S, Curmi PM, Andersson I, Cascio D, Sweet RM, Brändén CI, Eisenberg D. Crystal structure of activated tobacco rubisco complexed with the reaction-intermediate analogue 2-carboxy-arabinitol 1,5-bisphosphate. Protein Science : a Publication of the Protein Society. 2: 1136-46. PMID 8358296 DOI: 10.1002/Pro.5560020708  0.409
1993 Schreuder HA, Knight S, Curmi PM, Andersson I, Cascio D, Brändén CI, Eisenberg D. Formation of the active site of ribulose-1,5-bisphosphate carboxylase/oxygenase by a disorder-order transition from the unactivated to the activated form. Proceedings of the National Academy of Sciences of the United States of America. 90: 9968-72. PMID 8234342 DOI: 10.1073/Pnas.90.21.9968  0.337
1993 Lovejoy B, Cascio D, Eisenberg D. Crystal structure of canine and bovine granulocyte-colony stimulating factor (G-CSF) Journal of Molecular Biology. 234: 640-653. PMID 7504736 DOI: 10.1006/Jmbi.1993.1617  0.335
1992 Lovejoy B, Thanh Chau Le, Luthy R, Cascio D, O'Neil KT, Degrado WF, Eisenberg D. X-ray grade crystals of a designed α-helical coiled coil Protein Science. 1: 956-957. PMID 1304378 DOI: 10.1002/Pro.5560010714  0.304
1992 Curmi PMG, Cascio D, Sweet RM, Eisenberg D, Schreuder H. Crystal structure of the unactivated form of ribulose-1,5-bisphosphate carboxylase/oxygenase from tobacco refined at 2.0-A resolution. Journal of Biological Chemistry. 267: 16980-16989. DOI: 10.2210/Pdb3Rub/Pdb  0.404
1989 Larsen TA, Goodsell DS, Cascio D, Grzeskowiak K, Dickerson RE. The structure of DAPI bound to DNA Journal of Biomolecular Structure and Dynamics. 7: 477-491. PMID 2627296 DOI: 10.1080/07391102.1989.10508505  0.326
1989 Yamashita MM, Almassy RJ, Janson CA, Cascio D, Eisenberg D. Refined atomic model of glutamine synthetase at 3.5 Å resolution Journal of Biological Chemistry. 264: 17681-17690. PMID 2572586 DOI: 10.2210/Pdb2Gls/Pdb  0.363
1988 Chapman MS, Suh SW, Curmi PM, Cascio D, Smith WW, Eisenberg DS. Tertiary structure of plant RuBisCO: domains and their contacts. Science (New York, N.Y.). 241: 71-4. PMID 3133767 DOI: 10.1126/Science.3133767  0.352
1987 Suh SW, Cascio D, Chapman MS, Eisenberg D. A crystal form of ribulose-1,5-bisphosphate carboxylase/oxygenase from Nicotiana tabacum in the activated state. Journal of Molecular Biology. 197: 363-5. PMID 3681999 DOI: 10.1016/0022-2836(87)90129-X  0.379
1987 Chapman MS, Suh SW, Cascio D, Smith WW, Eisenberg D. Sliding-layer conformational change limited by the quaternary structure of plant RuBisCO. Nature. 329: 354-6. PMID 3627277 DOI: 10.1038/329354A0  0.353
1986 McPherson A, Brayer G, Cascio D, Williams R. The mechanism of binding of a polynucleotide chain to pancreatic ribonuclease Science. 232: 765-768. PMID 3961503 DOI: 10.1126/Science.3961503  0.379
1984 Cascio D, Williams R, McPherson A. The reduction of radiation damage in protein crystals by polyethylene glycol Journal of Applied Crystallography. 17: 209-210. DOI: 10.1107/S0021889884011316  0.303
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