Year |
Citation |
Score |
2024 |
Alkan C, O'Brien T, Kenyon V, Ikegami T. Computer-Selected Antiviral Compounds: Assessing In Vitro Efficacies against Rift Valley Fever Virus. Viruses. 16. PMID 38257788 DOI: 10.3390/v16010088 |
0.303 |
|
2015 |
Jameson JB, Kenyon V, Holman TR. A high-throughput mass spectrometric assay for discovery of human lipoxygenase inhibitors and allosteric effectors. Analytical Biochemistry. 476: 45-50. PMID 25712042 DOI: 10.1016/J.Ab.2015.02.011 |
0.451 |
|
2014 |
Armstrong MM, Diaz G, Kenyon V, Holman TR. Inhibitory and mechanistic investigations of oxo-lipids with human lipoxygenase isozymes. Bioorganic & Medicinal Chemistry. 22: 4293-7. PMID 24924423 DOI: 10.1016/J.Bmc.2014.05.025 |
0.39 |
|
2014 |
Rai G, Joshi N, Jung JE, Liu Y, Schultz L, Yasgar A, Perry S, Diaz G, Zhang Q, Kenyon V, Jadhav A, Simeonov A, Lo EH, van Leyen K, Maloney DJ, et al. Potent and selective inhibitors of human reticulocyte 12/15-lipoxygenase as anti-stroke therapies. Journal of Medicinal Chemistry. 57: 4035-48. PMID 24684213 DOI: 10.1021/Jm401915R |
0.559 |
|
2012 |
Weaver JR, Holman TR, Imai Y, Jadhav A, Kenyon V, Maloney DJ, Nadler JL, Rai G, Simeonov A, Taylor-Fishwick DA. Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction. Molecular and Cellular Endocrinology. 358: 88-95. PMID 22502743 DOI: 10.1016/J.Mce.2012.03.004 |
0.305 |
|
2012 |
Yeung J, Apopa PL, Vesci J, Kenyon V, Rai G, Jadhav A, Simeonov A, Holman TR, Maloney DJ, Boutaud O, Holinstat M. Protein kinase C regulation of 12-lipoxygenase-mediated human platelet activation Molecular Pharmacology. 81: 420-430. PMID 22155783 DOI: 10.1124/Mol.111.075630 |
0.398 |
|
2011 |
Kenyon V, Rai G, Jadhav A, Schultz L, Armstrong M, Jameson JB, Perry S, Joshi N, Bougie JM, Leister W, Taylor-Fishwick DA, Nadler JL, Holinstat M, Simeonov A, Maloney DJ, et al. Discovery of potent and selective inhibitors of human platelet-type 12-lipoxygenase Journal of Medicinal Chemistry. 54: 5485-5497. PMID 21739938 DOI: 10.1021/Jm2005089 |
0.588 |
|
2010 |
Rai G, Kenyon V, Jadhav A, Schultz L, Armstrong M, Jameson JB, Hoobler E, Leister W, Simeonov A, Holman TR, Maloney DJ. Discovery of potent and selective inhibitors of human reticulocyte 15-lipoxygenase-1 Journal of Medicinal Chemistry. 53: 7392-7404. PMID 20866075 DOI: 10.1021/Jm1008852 |
0.569 |
|
2009 |
Wecksler AT, Kenyon V, Garcia NK, Deschamps JD, Van Der Donk WA, Holman TR. Kinetic and structural investigations of the allosteric site in human epithelial 15-lipoxygenase-2 Biochemistry. 48: 8721-8730. PMID 19645454 DOI: 10.1021/Bi9009242 |
0.326 |
|
2008 |
van Leyen K, Arai K, Jin G, Kenyon V, Gerstner B, Rosenberg PA, Holman TR, Lo EH. Novel lipoxygenase inhibitors as neuroprotective reagents. Journal of Neuroscience Research. 86: 904-9. PMID 17960827 DOI: 10.1002/jnr.21543 |
0.38 |
|
2007 |
Vasquez-Martinez Y, Ohri RV, Kenyon V, Holman TR, Sepúlveda-Boza S. Structure-activity relationship studies of flavonoids as potent inhibitors of human platelet 12-hLO, reticulocyte 15-hLO-1, and prostate epithelial 15-hLO-2 Bioorganic and Medicinal Chemistry. 15: 7408-7425. PMID 17869117 DOI: 10.1016/J.Bmc.2007.07.036 |
0.508 |
|
2006 |
Deschamps JD, Kenyon VA, Holman TR. Baicalein is a potent in vitro inhibitor against both reticulocyte 15-human and platelet 12-human lipoxygenases Bioorganic and Medicinal Chemistry. 14: 4295-4301. PMID 16500106 DOI: 10.1016/J.Bmc.2006.01.057 |
0.539 |
|
2006 |
Kenyon V, Chorny I, Carvajal WJ, Holman TR, Jacobson MP. Novel human lipoxygenase inhibitors discovered using virtual screening with homology models Journal of Medicinal Chemistry. 49: 1356-1363. PMID 16480270 DOI: 10.1021/Jm050639J |
0.553 |
|
2005 |
Cichewicz RH, Clifford LJ, Lassen PR, Cao X, Freedman TB, Nafie LA, Deschamps JD, Kenyon VA, Flanary JR, Holman TR, Crews P. Stereochemical determination and bioactivity assessment of (S)-(+)-curcuphenol dimers isolated from the marine sponge Didiscus aceratus and synthesized through laccase biocatalysis. Bioorganic & Medicinal Chemistry. 13: 5600-12. PMID 16039133 DOI: 10.1016/J.Bmc.2005.06.020 |
0.343 |
|
2004 |
Cichewicz RH, Kenyon VA, Whitman S, Morales NM, Arguello JF, Holman TR, Crews P. Redox inactivation of human 15-lipoxygenase by marine-derived meroditerpenes and synthetic chromanes: Archetypes for a unique class of selective and recyclable inhibitors Journal of the American Chemical Society. 126: 14910-14920. PMID 15535718 DOI: 10.1021/Ja046082Z |
0.561 |
|
2004 |
Ruddat VC, Mogul R, Chorny I, Chen C, Perrin N, Whitman S, Kenyon V, Jacobson MP, Bernasconi CF, Holman TR. Tryptophan 500 and arginine 707 define product and substrate active site binding in soybean lipoxygenase-1 Biochemistry. 43: 13063-13071. PMID 15476400 DOI: 10.1021/Bi0489098 |
0.305 |
|
2004 |
Segraves EN, Shah RR, Segraves NL, Johnson TA, Whitman S, Sui JK, Kenyon VA, Cichewicz RH, Crews P, Holman TR. Probing the activity differences of simple and complex brominated aryl compounds against 15-soybean, 15-human, and 12-human lipoxygenase. Journal of Medicinal Chemistry. 47: 4060-5. PMID 15267244 DOI: 10.1021/Jm049872S |
0.476 |
|
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