Kendall W. Nettles, Ph.D. - Publications

Affiliations: 
University of Chicago, Chicago, IL 
Area:
breast cancer, steroid hormone action

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Min CK, Nwachukwu JC, Hou Y, Russo RJ, Papa A, Min J, Peng R, Kim SH, Ziegler Y, Rangarajan ES, Izard T, Katzenellenbogen BS, Katzenellenbogen JA, Nettles KW. Asymmetric allostery in estrogen receptor-α homodimers drives responses to the ensemble of estrogens in the hormonal milieu. Proceedings of the National Academy of Sciences of the United States of America. 121: e2321344121. PMID 38830107 DOI: 10.1073/pnas.2321344121  0.525
2024 Min CK, Nwachukwu JC, Hou Y, Russo RJ, Papa A, Min J, Peng R, Kim SH, Ziegler Y, Rangarajan ES, Izard T, Katzenellenbogen BS, Katzenellenbogen JA, Nettles KW. Asymmetric Allostery in Estrogen Receptor-α Homodimers Drives Responses to the Ensemble of Estrogens in the Hormonal Milieu. Biorxiv : the Preprint Server For Biology. PMID 38645081 DOI: 10.1101/2024.04.10.588871  0.526
2023 Iii JY, Gomes F, Durbin K, Schauer K, Nwachukwu J, Russo R, Njeri J, Saviola A, McClatchy D, Diedrich J, Garrett P, Papa A, Ciolacu I, Kelleher N, Nettles K. Native top-down proteomics reveals EGFR-ERα signaling crosstalk in breast cancer cells dissociates NUTF2 dimers to modulate ERα signaling and cell growth. Research Square. PMID 37546719 DOI: 10.21203/rs.3.rs-3097806/v1  0.332
2022 Tinivella A, Nwachukwu JC, Angeli A, Foschi F, Benatti AL, Pinzi L, Izard T, Ferraroni M, Erumbi R, Christodoulou MS, Passarella D, Supuran CT, Nettles KW, Rastelli G. Design, synthesis, biological evaluation and crystal structure determination of dual modulators of carbonic anhydrases and estrogen receptors. European Journal of Medicinal Chemistry. 246: 115011. PMID 36516582 DOI: 10.1016/j.ejmech.2022.115011  0.393
2021 Min J, Nwachukwu JC, Min CK, Njeri JW, Srinivasan S, Rangarajan ES, Nettles CC, Sanabria Guillen V, Ziegler Y, Yan S, Carlson KE, Hou Y, Kim SH, Novick S, Pascal BD, ... ... Nettles KW, et al. Dual-mechanism estrogen receptor inhibitors. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34452998 DOI: 10.1073/pnas.2101657118  0.482
2021 Bruno NE, Nwachukwu JC, Srinivasan S, Nettles CC, Izard T, Jin Z, Nowak J, Cameron MD, Boregowda SV, Phinney DG, Elemento O, Liu X, Ortlund EA, Houtman R, Stavreva DA, ... ... Nettles KW, et al. Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling. Nature Chemical Biology. PMID 33510451 DOI: 10.1038/s41589-020-00719-w  0.378
2020 Laws MJ, Ziegler Y, Shahoei SH, Dey P, Kim SH, Yasuda M, Park BH, Nettles KW, Katzenellenbogen JA, Nelson ER, Katzenellenbogen BS. Suppression of breast cancer metastasis and extension of survival by a new antiestrogen in a preclinical model driven by mutant estrogen receptors. Breast Cancer Research and Treatment. PMID 32277377 DOI: 10.1007/S10549-020-05629-Y  0.383
2020 Nwachukwu J, Min J, Srinivasan SK, Rangarajan E, Guillen VS, Ziegler Y, Carlson K, Hou Y, Kim SH, Izard T, Houtman R, Katzenellenbogen BS, Nettles KW, Katzenellenbogen JA. OR12-07 Full Antagonism of Breast Cancer Cell Proliferation Can Result from Many Ligand-Induced Conformational Distortions of the Estrogen Receptor Ligand Binding Domain Journal of the Endocrine Society. 4. DOI: 10.1210/Jendso/Bvaa046.249  0.553
2020 Katzenellenbogen JA, Min J, Srinivasan S, Rangarajan ES, Nwachukwu JC, Guillen VS, Ziegler Y, Yan S, Carlson KE, Hou Y, Kim SH, Izard T, Houtman R, Nettles KW, Katzenellenbogen BS. Abstract P6-04-10: Combining direct and indirect modes of antiestrogen ligand antagonism of estrogen receptor activity in breast cancer Cancer Research. 80. DOI: 10.1158/1538-7445.Sabcs19-P6-04-10  0.498
2019 Lo YC, Cormier O, Liu T, Nettles KW, Katzenellenbogen JA, Stearns T, Altman RB. Pocket similarity identifies selective estrogen receptor modulators as microtubule modulators at the taxane site. Nature Communications. 10: 1033. PMID 30833575 DOI: 10.1038/S41467-019-08965-W  0.471
2019 Zhang B, Kiefer JR, Blake RA, Chang JH, Hartman S, Ingalla ER, Kleinheinz T, Mody V, Nannini M, Ortwine DF, Ran Y, Sambrone A, Sampath D, Vinogradova M, Zhong Y, ... ... Nettles KW, et al. Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Bioorganic & Medicinal Chemistry Letters. PMID 30732944 DOI: 10.1016/J.Bmcl.2019.01.036  0.558
2019 Mediouni S, Chinthalapudi K, Ekka MK, Usui I, Jablonski JA, Clementz MA, Mousseau G, Nowak J, Macherla VR, Beverage JN, Esquenazi E, Baran P, de Vera IMS, Kojetin D, Loret EP, ... Nettles K, et al. Didehydro-Cortistatin A Inhibits HIV-1 by Specifically Binding to the Unstructured Basic Region of Tat. Mbio. 10. PMID 30723126 DOI: 10.1128/Mbio.02662-18  0.323
2018 Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, Lainé M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, ... ... Nettles KW, et al. The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells. Elife. 7. PMID 30489256 DOI: 10.7554/Elife.37161  0.587
2018 Hudson WH, Vera IMS, Nwachukwu JC, Weikum ER, Herbst AG, Yang Q, Bain DL, Nettles KW, Kojetin DJ, Ortlund EA. Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements. Nature Communications. 9: 1337. PMID 29626214 DOI: 10.1038/S41467-018-03780-1  0.42
2018 Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, Lainé M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, ... ... Nettles KW, et al. Author response: The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells Elife. DOI: 10.7554/Elife.37161.024  0.486
2017 Katzenellenbogen BS, Zhao Y, Laws MJ, Sanabria Guillen V, Ziegler Y, Min J, Sharma A, Kim SH, Chu D, Park BH, Oesterreich S, Mao C, Shapiro DJ, Nettles KW, Katzenellenbogen JA. Structurally novel antiestrogens elicit differential responses from constitutively active mutant estrogen receptors in breast cancer cells and tumors. Cancer Research. PMID 28904064 DOI: 10.1158/0008-5472.Can-17-1265  0.414
2017 Min J, Guillen VS, Sharma A, Zhao Y, Ziegler Y, Gong P, Mayne CG, Srinivasan S, Kim SH, Carlson KE, Nettles KW, Katzenellenbogen BS, Katzenellenbogen JA. Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor (ER)-Mediated Activities in Breast Cancer Cells. Journal of Medicinal Chemistry. PMID 28657320 DOI: 10.1021/Acs.Jmedchem.7B00585  0.503
2017 Weikum ER, de Vera IMS, Nwachukwu JC, Hudson WH, Nettles KW, Kojetin DJ, Ortlund EA. Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes. Nucleic Acids Research. PMID 28591827 DOI: 10.1093/Nar/Gkx509  0.42
2017 Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, ... ... Nettles KW, et al. Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain. Nature Chemical Biology. 13: 691. PMID 28514424 DOI: 10.1038/Nchembio0617-691C  0.351
2017 Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, ... ... Nettles KW, et al. Erratum: Full antagonism of the estrogen receptor without a prototypical ligand side chain. Nature Chemical Biology. 13: 691. PMID 28514419 DOI: 10.1038/nchembio0617-691b  0.447
2017 Stender JD, Nwachukwu JC, Kastrati I, Kim Y, Strid T, Yakir M, Srinivasan S, Nowak J, Izard T, Rangarajan ES, Carlson KE, Katzenellenbogen JA, Yao XQ, Grant BJ, Leong HS, ... ... Nettles KW, et al. Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells. Molecular Cell. 65: 1122-1135.e5. PMID 28306507 DOI: 10.1016/J.Molcel.2017.02.008  0.397
2016 Nwachukwu JC, Srinivasan S, Bruno NE, Nowak J, Wright NJ, Minutolo F, Rangarajan ES, Izard T, Yao XQ, Grant BJ, Kojetin DJ, Elemento O, Katzenellenbogen JA, Nettles KW. Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies. Cell Chemical Biology. PMID 28042045 DOI: 10.1016/J.Chembiol.2016.11.014  0.496
2016 Sharma N, Carlson KE, Nwachukwu JC, Srinivasan S, Sharma A, Nettles KW, Katzenellenbogen JA. Exploring the Structural Compliancy versus Specificity of the Estrogen Receptor Using Isomeric Three-Dimensional Ligands. Acs Chemical Biology. PMID 28032978 DOI: 10.1021/Acschembio.6B00918  0.595
2016 Jin Z, Lin H, Srinivasan S, Nwachukwu JC, Bruno N, Griffin PR, Nettles KW, Kamenecka TM. Synthesis of novel steroidal agonists, partial agonists, and antagonists for the glucocorticoid receptor. Bioorganic & Medicinal Chemistry Letters. PMID 27919657 DOI: 10.1016/J.Bmcl.2016.11.007  0.5
2016 Srinivasan S, Nwachukwu JC, Bruno NE, Dharmarajan V, Goswami D, Kastrati I, Novick S, Nowak J, Cavett V, Zhou HB, Boonmuen N, Zhao Y, Min J, Frasor J, Katzenellenbogen BS, ... ... Nettles KW, et al. Full antagonism of the estrogen receptor without a prototypical ligand side chain. Nature Chemical Biology. PMID 27870835 DOI: 10.1038/Nchembio.2236  0.543
2016 Nwachukwu JC, Srinivasan S, Zheng Y, Wang S, Min J, Dong C, Liao Z, Nowak J, Wright NJ, Houtman R, Carlson KE, Josan JS, Elemento O, Katzenellenbogen JA, Zhou HB, ... Nettles KW, et al. Predictive features of ligand-specific signaling through the estrogen receptor. Molecular Systems Biology. 12: 864. PMID 27107013 DOI: 10.15252/Msb.20156701  0.546
2016 Nwachukwu JC, Srinivasan S, Zheng Y, Wang S, Min J, Dong C, Liao Z, Nowak J, Wright NJ, Houtman R, Carlson KE, Josan JS, Elemento O, Katzenellenbogen JA, Zhou HB, ... Nettles KW, et al. Predictive features of ligand-specific signaling through the estrogen receptor Molecular Systems Biology. 12. DOI: 10.15252/msb.20156701  0.467
2015 Kojetin DJ, Matta-Camacho E, Hughes TS, Srinivasan S, Nwachukwu JC, Cavett V, Nowak J, Chalmers MJ, Marciano DP, Kamenecka TM, Shulman AI, Rance M, Griffin PR, Bruning JB, Nettles KW. Structural mechanism for signal transduction in RXR nuclear receptor heterodimers. Nature Communications. 6: 8013. PMID 26289479 DOI: 10.1038/Ncomms9013  0.502
2015 Zhao Y, Gong P, Chen Y, Nwachukwu JC, Srinivasan S, Ko C, Bagchi MK, Taylor RN, Korach KS, Nettles KW, Katzenellenbogen JA, Katzenellenbogen BS. Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis. Science Translational Medicine. 7: 271ra9. PMID 25609169 DOI: 10.1126/Scitranslmed.3010626  0.36
2015 Kojetin DJ, Matta-Camacho E, Hughes TS, Srinivasan S, Nwachukwu JC, Cavett V, Nowak J, Chalmers MJ, Marciano DP, Kamenecka TM, Shulman AI, Rance M, Griffin PR, Bruning JB, Nettles KW. Structural mechanism for signal transduction in RXR nuclear receptor heterodimers Nature Communications. 6. DOI: 10.1038/ncomms9013  0.348
2014 Nwachukwu JC, Srinivasan S, Bruno NE, Parent AA, Hughes TS, Pollock JA, Gjyshi O, Cavett V, Nowak J, Garcia-Ordonez RD, Houtman R, Griffin PR, Kojetin DJ, Katzenellenbogen JA, Conkright MD, ... Nettles KW, et al. Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network. Elife. 3: e02057. PMID 24771768 DOI: 10.7554/Elife.02057  0.376
2014 Liao ZQ, Dong C, Carlson KE, Srinivasan S, Nwachukwu JC, Chesnut RW, Sharma A, Nettles KW, Katzenellenbogen JA, Zhou HB. Triaryl-substituted Schiff bases are high-affinity subtype-selective ligands for the estrogen receptor. Journal of Medicinal Chemistry. 57: 3532-45. PMID 24708493 DOI: 10.1021/Jm500268J  0.489
2014 Nwachukwu JC, Srinivasan S, Bruno NE, Parent AA, Hughes TS, Pollock JA, Gjyshi O, Cavett V, Nowak J, Garcia-Ordonez RD, Houtman R, Griffin PR, Kojetin DJ, Katzenellenbogen JA, Conkright MD, ... Nettles KW, et al. Author response: Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network Elife. DOI: 10.7554/Elife.02057.040  0.358
2013 Min J, Wang P, Srinivasan S, Nwachukwu JC, Guo P, Huang M, Carlson KE, Katzenellenbogen JA, Nettles KW, Zhou HB. Thiophene-core estrogen receptor ligands having superagonist activity. Journal of Medicinal Chemistry. 56: 3346-66. PMID 23586645 DOI: 10.1021/Jm400157E  0.563
2013 Srinivasan S, Nwachukwu JC, Parent AA, Cavett V, Nowak J, Hughes TS, Kojetin DJ, Katzenellenbogen JA, Nettles KW. Ligand-binding dynamics rewire cellular signaling via estrogen receptor-α. Nature Chemical Biology. 9: 326-32. PMID 23524984 DOI: 10.1038/Nchembio.1214  0.53
2012 Laughlin JD, Nwachukwu JC, Figuera-Losada M, Cherry L, Nettles KW, LoGrasso PV. Structural mechanisms of allostery and autoinhibition in JNK family kinases. Structure (London, England : 1993). 20: 2174-84. PMID 23142346 DOI: 10.1016/J.Str.2012.09.021  0.355
2012 Zhu M, Zhang C, Nwachukwu JC, Srinivasan S, Cavett V, Zheng Y, Carlson KE, Dong C, Katzenellenbogen JA, Nettles KW, Zhou HB. Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides. Organic & Biomolecular Chemistry. 10: 8692-700. PMID 23033157 DOI: 10.1039/C2Ob26531A  0.557
2012 Zheng Y, Zhu M, Srinivasan S, Nwachukwu JC, Cavett V, Min J, Carlson KE, Wang P, Dong C, Katzenellenbogen JA, Nettles KW, Zhou HB. Development of selective estrogen receptor modulator (SERM)-like activity through an indirect mechanism of estrogen receptor antagonism: defining the binding mode of 7-oxabicyclo[2.2.1]hept-5-ene scaffold core ligands. Chemmedchem. 7: 1094-100. PMID 22517684 DOI: 10.1002/Cmdc.201200048  0.583
2012 Wang P, Min J, Nwachukwu JC, Cavett V, Carlson KE, Guo P, Zhu M, Zheng Y, Dong C, Katzenellenbogen JA, Nettles KW, Zhou HB. Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide. Journal of Medicinal Chemistry. 55: 2324-41. PMID 22283328 DOI: 10.1021/Jm201556R  0.544
2012 Nwachukwu JC, Nettles KW. The nuclear receptor signalling scaffold: insights from full-length structures. The Embo Journal. 31: 251-3. PMID 22252143 DOI: 10.1038/Emboj.2011.475  0.49
2012 Kumar A, Park H, Fang P, Parkesh R, Guo M, Nettles KW, Disney. Crystal Structure of the Triplet Repeat in Myotonic Dystrophy Reveals Heterogeneous 1x1 Nucleotide UU Internal Loop Conformations Biochemistry. 50: 9928-9935. DOI: 10.2210/Pdb3Syw/Pdb  0.314
2011 Kumar A, Fang P, Park H, Guo M, Nettles KW, Disney MD. A crystal structure of a model of the repeating r(CGG) transcript found in fragile X syndrome. Chembiochem : a European Journal of Chemical Biology. 12: 2140-2. PMID 21766409 DOI: 10.1002/Cbic.201100337  0.309
2010 Bruning JB, Parent AA, Gil G, Zhao M, Nowak J, Pace MC, Smith CL, Afonine PV, Adams PD, Katzenellenbogen JA, Nettles KW. Coupling of receptor conformation and ligand orientation determine graded activity. Nature Chemical Biology. 6: 837-43. PMID 20924370 DOI: 10.1038/Nchembio.451  0.552
2008 Nettles KW. Insights into PPARgamma from structures with endogenous and covalently bound ligands. Nature Structural & Molecular Biology. 15: 893-5. PMID 18769464 DOI: 10.1038/Nsmb0908-893  0.513
2008 Nettles KW, Bruning JB, Gil G, Nowak J, Sharma SK, Hahm JB, Kulp K, Hochberg RB, Zhou H, Katzenellenbogen JA, Katzenellenbogen BS, Kim Y, Joachmiak A, Greene GL. NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses. Nature Chemical Biology. 4: 241-7. PMID 18344977 DOI: 10.1038/Nchembio.76  0.669
2008 Nettles KW, Gil G, Nowak J, Métivier R, Sharma VB, Greene GL. CBP is a dosage-dependent regulator of nuclear factor-κB suppression by the estrogen receptor Molecular Endocrinology. 22: 263-272. PMID 17932106 DOI: 10.1210/Me.2007-0324  0.565
2008 Nettles KW, Bruning JB, Gil G, Nowak J, Sharma SK, Hahm JB, Kulp K, Hochberg RB, Zhou H, Katzenellenbogen JA, Katzenellenbogen BS, Kim Y, Joachimiak A, Greene GL. Corrigendum: NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses (Nature Chemical Biology (2008) 4, (241-247)) Nature Chemical Biology. 4: 379. DOI: 10.1038/Nchembio0608-379B  0.643
2007 Bruning JB, Chalmers MJ, Prasad S, Busby SA, Kamenecka TM, He Y, Nettles KW, Griffin PR. Partial agonists activate PPARgamma using a helix 12 independent mechanism. Structure (London, England : 1993). 15: 1258-71. PMID 17937915 DOI: 10.1016/J.Str.2007.07.014  0.486
2007 Zhou HB, Nettles KW, Bruning JB, Kim Y, Joachimiak A, Sharma S, Carlson KE, Stossi F, Katzenellenbogen BS, Greene GL, Katzenellenbogen JA. Elemental Isomerism: A Boron-Nitrogen Surrogate for a Carbon-Carbon Double Bond Increases the Chemical Diversity of Estrogen Receptor Ligands Chemistry and Biology. 14: 659-669. PMID 17584613 DOI: 10.1016/J.Chembiol.2007.04.009  0.595
2007 Nettles KW, Bruning JB, Gil G, O'Neill EE, Nowak J, Hughs A, Kim Y, DeSombre ER, Dilis R, Hanson RN, Joachimiak A, Greene GL. Structural plasticity in the oestrogen receptor ligand-binding domain Embo Reports. 8: 563-568. PMID 17468738 DOI: 10.1038/Sj.Embor.7400963  0.734
2007 Zhou HB, Sheng S, Compton DR, Kim Y, Joachimiak A, Sharma S, Carlson KE, Katzenellenbogen BS, Nettles KW, Greene GL, Katzenellenbogen JA. Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains. Journal of Medicinal Chemistry. 50: 399-403. PMID 17228884 DOI: 10.1021/Jm061035Y  0.67
2005 Nettles KW, Greene GL. Ligand control of coregulator recruitment to nuclear receptors Annual Review of Physiology. 67: 309-333. PMID 15709961 DOI: 10.1146/Annurev.Physiol.66.032802.154710  0.653
2004 Greene GL, Shiau AK, Nettles KW. A structural explanation for ERalpha/ERbeta SERM discrimination. Ernst Schering Research Foundation Workshop. 33-45. PMID 15248503 DOI: 10.1007/978-3-662-05386-7_3  0.563
2004 Nettles KW, Sun J, Radek JT, Sheng S, Rodriguez AL, Katzenellenbogen JA, Katzenellenbogen BS, Greene GL. Allosteric Control of Ligand Selectivity between Estrogen Receptors α and β: Implications for Other Nuclear Receptors Molecular Cell. 13: 317-327. PMID 14967140 DOI: 10.1016/S1097-2765(04)00054-1  0.678
2003 Nettles KW, Greene GL. Nuclear receptor ligands and cofactor recruitment: Is there a coactivator "On Deck"? Molecular Cell. 11: 850-851. PMID 12718871 DOI: 10.1016/S1097-2765(03)00133-3  0.636
2002 Shiau AK, Barstad D, Radek JT, Meyers MJ, Nettles KW, Katzenellenbogen BS, Katzenellenbogen JA, Agard DA, Greene GL. Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism. Nature Structural Biology. 9: 359-64. PMID 11953755 DOI: 10.1038/Nsb787  0.583
Show low-probability matches.