Hunter C. Champion, Ph.D. - Publications

Affiliations: 
2000 Tulane University, New Orleans, LA, United States 
Area:
err

258 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2014 Hill MR, Simon MA, Valdez-Jasso D, Zhang W, Champion HC, Sacks MS. Structural and mechanical adaptations of right ventricle free wall myocardium to pressure overload. Annals of Biomedical Engineering. 42: 2451-65. PMID 25164124 DOI: 10.1007/S10439-014-1096-3  1
2014 Lai YC, Potoka KC, Champion HC, Mora AL, Gladwin MT. Pulmonary arterial hypertension: the clinical syndrome. Circulation Research. 115: 115-30. PMID 24951762 DOI: 10.1161/Circresaha.115.301146  1
2014 Simon MA, Lacomis CD, George MP, Kessinger C, Weinman R, McMahon D, Gladwin MT, Champion HC, Morris A. Isolated right ventricular dysfunction in patients with human immunodeficiency virus. Journal of Cardiac Failure. 20: 414-21. PMID 24726418 DOI: 10.1016/J.Cardfail.2014.03.009  1
2014 Shankarraman V, Kocyildirim E, Olia SE, Kameneva MV, Dzadony RJ, Maul TM, Simon MA, Champion HC, Wagner WR, Bermudez CA. Biocompatibility Assessment of the CentriMag-Novalung Adult ECMO Circuit in a Model of Acute Pulmonary Hypertension. Asaio Journal (American Society For Artificial Internal Organs : 1992). 60: 429-35. PMID 24658516 DOI: 10.1097/Mat.0000000000000079  1
2014 Qin D, Patel SM, Champion HC. "Happiness" and stress cardiomyopathy (apical ballooning syndrome/takotsubo syndrome). International Journal of Cardiology. 172: e182-3. PMID 24507745 DOI: 10.1016/j.ijcard.2013.12.140  1
2014 Kelley EE, Baust J, Bonacci G, Golin-Bisello F, Devlin JE, St. Croix CM, Watkins SC, Gor S, Cantu-Medellin N, Weidert ER, Frisbee JC, Gladwin MT, Champion HC, Freeman BA, Khoo NKH. Fatty acid nitroalkenes ameliorate glucose intolerance and pulmonary hypertension in high-fat diet-induced obesity Cardiovascular Research. 101: 352-363. PMID 24385344 DOI: 10.1093/Cvr/Cvt341  1
2014 Musicki B, Bivalacqua TJ, Champion HC, Burnett AL. Sildenafil promotes eNOS activation and inhibits NADPH oxidase in the transgenic sickle cell mouse penis. The Journal of Sexual Medicine. 11: 424-30. PMID 24251665 DOI: 10.1111/Jsm.12391  1
2014 Frazziano G, Al Ghouleh I, Baust J, Shiva S, Champion HC, Pagano PJ. Nox-derived ROS are acutely activated in pressure overload pulmonary hypertension: indications for a seminal role for mitochondrial Nox4. American Journal of Physiology. Heart and Circulatory Physiology. 306: H197-205. PMID 24213612 DOI: 10.1152/ajpheart.00977.2012  1
2014 Shatat MA, Tian H, Zhang R, Tandon G, Hale A, Fritz JS, Zhou G, Martínez-González J, Rodríguez C, Champion HC, Jain MK, Hamik A. Endothelial Krüppel-like factor 4 modulates pulmonary arterial hypertension. American Journal of Respiratory Cell and Molecular Biology. 50: 647-53. PMID 24156273 DOI: 10.1165/rcmb.2013-0135OC  1
2014 Allen RA, Wu W, Yao M, Dutta D, Duan X, Bachman TN, Champion HC, Stolz DB, Robertson AM, Kim K, Isenberg JS, Wang Y. Nerve regeneration and elastin formation within poly(glycerol sebacate)-based synthetic arterial grafts one-year post-implantation in a rat model. Biomaterials. 35: 165-73. PMID 24119457 DOI: 10.1016/j.biomaterials.2013.09.081  1
2013 Bachman TN, Bursic JJ, Simon MA, Champion HC. A Novel Acquisition Technique to Utilize Swan-Ganz Catheter data as a Surrogate for High-fidelity Micromanometry within the Right Ventricle and Pulmonary Circuit. Cardiovascular Engineering and Technology. 4: 183-191. PMID 25484997 DOI: 10.1007/s13239-013-0124-z  1
2013 Seeger W, Adir Y, Barberà JA, Champion H, Coghlan JG, Cottin V, De Marco T, Galiè N, Ghio S, Gibbs S, Martinez FJ, Semigran MJ, Simonneau G, Wells AU, Vachiéry JL. Pulmonary hypertension in chronic lung diseases. Journal of the American College of Cardiology. 62: D109-16. PMID 24355635 DOI: 10.1016/J.Jacc.2013.10.036  1
2013 Vachiéry JL, Adir Y, Barberà JA, Champion H, Coghlan JG, Cottin V, De Marco T, Galiè N, Ghio S, Gibbs JS, Martinez F, Semigran M, Simonneau G, Wells A, Seeger W. Pulmonary hypertension due to left heart diseases. Journal of the American College of Cardiology. 62: D100-8. PMID 24355634 DOI: 10.1016/j.jacc.2013.10.033  1
2013 Graham BB, Chabon J, Gebreab L, Poole J, Debella E, Davis L, Tanaka T, Sanders L, Dropcho N, Bandeira A, Vandivier RW, Champion HC, Butrous G, Wang XJ, Wynn TA, et al. Transforming growth factor-β signaling promotes pulmonary hypertension caused by Schistosoma mansoni. Circulation. 128: 1354-64. PMID 23958565 DOI: 10.1161/Circulationaha.113.003072  1
2013 Bivalacqua TJ, Musicki B, Hsu LL, Berkowitz DE, Champion HC, Burnett AL. Sildenafil citrate-restored eNOS and PDE5 regulation in sickle cell mouse penis prevents priapism via control of oxidative/nitrosative stress. Plos One. 8: e68028. PMID 23844149 DOI: 10.1371/Journal.Pone.0068028  1
2013 Davis EM, Ramratnam SK, Spahr JE, Champion HC. A typical case of atypical dyspnea. Annals of the American Thoracic Society. 10: 261-3. PMID 23802828 DOI: 10.1513/Annalsats.201303-041Ot  1
2013 Raat NJ, Tabima DM, Specht PA, Tejero J, Champion HC, Kim-Shapiro DB, Baust J, Mik EG, Hildesheim M, Stasch JP, Becker EM, Truebel H, Gladwin MT. Direct sGC activation bypasses NO scavenging reactions of intravascular free oxy-hemoglobin and limits vasoconstriction. Antioxidants & Redox Signaling. 19: 2232-43. PMID 23697678 DOI: 10.1089/ars.2013.5181  1
2013 Champion HC. When to initiate intravenous therapy and/or refer. The American Journal of Cardiology. 111: 21C-4C. PMID 23558027 DOI: 10.1016/j.amjcard.2013.01.321  1
2013 George MP, Champion HC, Simon M, Guyach S, Tarantelli R, Kling HM, Brower A, Janssen C, Murphy J, Carney JP, Morris A, Gladwin MT, Norris KA. Physiologic changes in a nonhuman primate model of HIV-associated pulmonary arterial hypertension. American Journal of Respiratory Cell and Molecular Biology. 48: 374-81. PMID 23239493 DOI: 10.1165/Rcmb.2011-0434Oc  1
2013 Nagendran J, Sutendra G, Paterson I, Champion HC, Webster L, Chiu B, Haromy A, Rebeyka IM, Ross DB, Michelakis ED. Endothelin axis is upregulated in human and rat right ventricular hypertrophy. Circulation Research. 112: 347-54. PMID 23233754 DOI: 10.1161/CIRCRESAHA.111.300448  1
2012 Parakh K, Kittleson MM, Heidecker B, Wittstein IS, Judge DP, Champion HC, Barouch LA, Baughman KL, Russell SD, Kasper EK, Sitammagari KK, Hare JM. The variable natural history of idiopathic dilated cardiomyopathy. The Israel Medical Association Journal : Imaj. 14: 666-71. PMID 23240370  1
2012 Valdez-Jasso D, Simon MA, Champion HC, Sacks MS. A murine experimental model for the mechanical behaviour of viable right-ventricular myocardium. The Journal of Physiology. 590: 4571-84. PMID 22848044 DOI: 10.1113/Jphysiol.2012.233015  1
2012 George MP, Champion HC, Gladwin MT, Norris KA, Morris A. Injection drug use as a "second hit" in the pathogenesis of HIV-associated pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine. 185: 1144-6. PMID 22661521 DOI: 10.1164/Rccm.201204-0609Ed  1
2012 Khoo NK, Cantu-Medellin N, Devlin JE, St Croix CM, Watkins SC, Fleming AM, Champion HC, Mason RP, Freeman BA, Kelley EE. Obesity-induced tissue free radical generation: an in vivo immuno-spin trapping study. Free Radical Biology & Medicine. 52: 2312-9. PMID 22564528 DOI: 10.1016/J.Freeradbiomed.2012.04.011  1
2012 Kass DJ, Rattigan E, Kahloon R, Loh K, Yu L, Savir A, Markowski M, Saqi A, Rajkumar R, Ahmad F, Champion HC. Early treatment with fumagillin, an inhibitor of methionine aminopeptidase-2, prevents Pulmonary Hypertension in monocrotaline-injured rats. Plos One. 7: e35388. PMID 22509410 DOI: 10.1371/Journal.Pone.0035388  1
2012 Cruz JA, Bauer EM, Rodriguez AI, Gangopadhyay A, Zeineh NS, Wang Y, Shiva S, Champion HC, Bauer PM. Chronic hypoxia induces right heart failure in caveolin-1-/- mice. American Journal of Physiology. Heart and Circulatory Physiology. 302: H2518-27. PMID 22505641 DOI: 10.1152/Ajpheart.01140.2011  1
2012 Segal R, Hannan JL, Liu X, Kutlu O, Burnett AL, Champion HC, Kim JH, Steppan J, Berkowitz DE, Bivalacqua TJ. Chronic oral administration of the arginase inhibitor 2(S)-amino-6-boronohexanoic acid (ABH) improves erectile function in aged rats. Journal of Andrology. 33: 1169-75. PMID 22492840 DOI: 10.2164/Jandrol.111.015834  1
2012 Frazziano G, Champion HC, Pagano PJ. NADPH oxidase-derived ROS and the regulation of pulmonary vessel tone. American Journal of Physiology. Heart and Circulatory Physiology. 302: H2166-77. PMID 22427511 DOI: 10.1152/ajpheart.00780.2011  1
2012 Ahmad F, Champion HC, Kaminski N. Toward systems biology of pulmonary hypertension. Circulation. 125: 1477-9. PMID 22371329 DOI: 10.1161/CIRCULATIONAHA.112.096396  1
2012 Saggar R, Lewis GD, Systrom DM, Champion HC, Naeije R, Saggar R. Pulmonary vascular responses to exercise: a haemodynamic observation. The European Respiratory Journal. 39: 231-4. PMID 22298608 DOI: 10.1183/09031936.00166211  1
2012 Bauer PM, Bauer EM, Rogers NM, Yao M, Feijoo-Cuaresma M, Pilewski JM, Champion HC, Zuckerbraun BS, Calzada MJ, Isenberg JS. Activated CD47 promotes pulmonary arterial hypertension through targeting caveolin-1. Cardiovascular Research. 93: 682-93. PMID 22215724 DOI: 10.1093/Cvr/Cvr356  1
2012 Morris A, Gingo MR, George MP, Lucht L, Kessinger C, Singh V, Hillenbrand M, Busch M, McMahon D, Norris KA, Champion HC, Gladwin MT, Zhang Y, Steele C, Sciurba FC. Cardiopulmonary function in individuals with HIV infection in the antiretroviral therapy era. Aids (London, England). 26: 731-40. PMID 22210636 DOI: 10.1097/Qad.0B013E32835099Ae  1
2011 Zaiman AL, Damico R, Thoms-Chesley A, Files DC, Kesari P, Johnston L, Swaim M, Mozammel S, Myers AC, Halushka M, El-Haddad H, Shimoda LA, Peng CF, Hassoun PM, Champion HC, et al. A critical role for the protein apoptosis repressor with caspase recruitment domain in hypoxia-induced pulmonary hypertension. Circulation. 124: 2533-42. PMID 22082675 DOI: 10.1161/Circulationaha.111.034512  1
2011 Gebska MA, Stevenson BK, Hemnes AR, Bivalacqua TJ, Haile A, Hesketh GG, Murray CI, Zaiman AL, Halushka MK, Krongkaew N, Strong TD, Cooke CA, El-Haddad H, Tuder RM, Berkowitz DE, ... Champion HC, et al. Phosphodiesterase-5A (PDE5A) is localized to the endothelial caveolae and modulates NOS3 activity. Cardiovascular Research. 90: 353-63. PMID 21421555 DOI: 10.1093/Cvr/Cvq410  1
2011 Heidecker B, Kittleson MM, Kasper EK, Wittstein IS, Champion HC, Russell SD, Hruban RH, Rodriguez ER, Baughman KL, Hare JM. Transcriptomic biomarkers for the accurate diagnosis of myocarditis. Circulation. 123: 1174-84. PMID 21382894 DOI: 10.1161/CIRCULATIONAHA.110.002857  1
2011 Musicki B, Champion HC, Hsu LL, Bivalacqua TJ, Burnett AL. Post-translational inactivation of endothelial nitric oxide synthase in the transgenic sickle cell mouse penis. The Journal of Sexual Medicine. 8: 419-26. PMID 21143412 DOI: 10.1111/J.1743-6109.2010.02123.X  1
2011 George MP, Brower A, Kling H, Shipley T, Kristoff J, Reinhart TA, Murphey-Corb M, Gladwin MT, Champion HC, Morris A, Norris KA. Pulmonary vascular lesions are common in SIV- and SHIV-env-infected macaques Aids Research and Human Retroviruses. 27: 103-111. PMID 20961277 DOI: 10.1089/Aid.2009.0297  1
2011 Steen VD, Champion H. Is exercise-induced pulmonary hypertension ready for prime time in systemic sclerosis? International Journal of Clinical Practice. 65: 1-3. DOI: 10.1111/j.1742-1241.2010.02603.x  1
2010 Gratzke C, Strong TD, Gebska MA, Champion HC, Stief CG, Burnett AL, Bivalacqua TJ. Activated RhoA/Rho kinase impairs erectile function after cavernous nerve injury in rats. The Journal of Urology. 184: 2197-204. PMID 20851436 DOI: 10.1016/J.Juro.2010.06.094  1
2010 LaRocca TJ, Schwarzkopf M, Altman P, Zhang S, Gupta A, Gomes I, Alvin Z, Champion HC, Haddad G, Hajjar RJ, Devi LA, Schecter AD, Tarzami ST. β2-Adrenergic receptor signaling in the cardiac myocyte is modulated by interactions with CXCR4. Journal of Cardiovascular Pharmacology. 56: 548-59. PMID 20729750 DOI: 10.1097/Fjc.0B013E3181F713Fe  1
2010 Gregg CJ, Steppan J, Gonzalez DR, Champion HC, Phan AC, Nyhan D, Shoukas AA, Hare JM, Barouch LA, Berkowitz DE. β2-adrenergic receptor-coupled phosphoinositide 3-kinase constrains cAMP-dependent increases in cardiac inotropy through phosphodiesterase 4 activation. Anesthesia and Analgesia. 111: 870-7. PMID 20705779 DOI: 10.1213/Ane.0B013E3181Ee8312  1
2010 Graham BB, Mentink-Kane MM, El-Haddad H, Purnell S, Zhang L, Zaiman A, Redente EF, Riches DW, Hassoun PM, Bandeira A, Champion HC, Butrous G, Wynn TA, Tuder RM. Schistosomiasis-induced experimental pulmonary hypertension: role of interleukin-13 signaling. The American Journal of Pathology. 177: 1549-61. PMID 20671265 DOI: 10.2353/Ajpath.2010.100063  1
2010 Tankersley CG, Peng RD, Bedga D, Gabrielson K, Champion HC. Variation in echocardiographic and cardiac hemodynamic effects of PM and ozone inhalation exposure in strains related to Nppa and Npr1 gene knock-out mice. Inhalation Toxicology. 22: 695-707. PMID 20540624 DOI: 10.3109/08958378.2010.487549  1
2010 Bivalacqua TJ, Ross AE, Strong TD, Gebska MA, Musicki B, Champion HC, Burnett AL. Attenuated RhoA/Rho-kinase signaling in penis of transgenic sickle cell mice. Urology. 76: 510.e7-12. PMID 20538321 DOI: 10.1016/J.Urology.2010.02.050  1
2010 White AR, Ryoo S, Bugaj L, Attarzadeh DO, Thiyagarajan S, Chen K, Attwater S, Abbot B, Li D, Champion HC, Shoukas AA, Nyhan D, Hare JM, Berkowitz DE, Tuday EC. Early changes in vasoreactivity after simulated microgravity are due to an upregulation of the endothelium-dependent nitric oxide/cGMP pathway. European Journal of Applied Physiology. 110: 395-404. PMID 20512503 DOI: 10.1007/s00421-010-1514-7  1
2010 Campo A, Mathai SC, Le Pavec J, Zaiman AL, Hummers LK, Boyce D, Housten T, Champion HC, Lechtzin N, Wigley FM, Girgis RE, Hassoun PM. Hemodynamic predictors of survival in scleroderma-related pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine. 182: 252-60. PMID 20339143 DOI: 10.1164/Rccm.200912-1820Oc  1
2010 Heidecker B, Lamirault G, Kasper EK, Wittstein IS, Champion HC, Breton E, Russell SD, Hall J, Kittleson MM, Baughman KL, Hare JM. The gene expression profile of patients with new-onset heart failure reveals important gender-specific differences. European Heart Journal. 31: 1188-96. PMID 20031959 DOI: 10.1093/Eurheartj/Ehp549  1
2010 Deng W, Bivalacqua TJ, Champion HC, Hellstrom WJ, Murthy SN, Kadowitz PJ. Gene therapy techniques for the delivery of endothelial nitric oxide synthase to the lung for pulmonary hypertension. Methods in Molecular Biology (Clifton, N.J.). 610: 309-21. PMID 20013186 DOI: 10.1007/978-1-60327-029-8_18  1
2010 Deng W, Bivalacqua TJ, Champion HC, Hellstrom WJ, Murthy SN, Kadowitz PJ. Superoxide dismutase - a target for gene therapeutic approach to reduce oxidative stress in erectile dysfunction. Methods in Molecular Biology (Clifton, N.J.). 610: 213-27. PMID 20013181 DOI: 10.1007/978-1-60327-029-8_13  1
2010 White TA, Witt TA, Pan S, Mueske CS, Kleppe LS, Holroyd EW, Champion HC, Simari RD. Tissue factor pathway inhibitor overexpression inhibits hypoxia-induced pulmonary hypertension. American Journal of Respiratory Cell and Molecular Biology. 43: 35-45. PMID 19648471 DOI: 10.1165/Rcmb.2009-0144Oc  1
2010 Mathai SC, Bueso M, Hummers LK, Boyce D, Lechtzin N, Le Pavec J, Campo A, Champion HC, Housten T, Forfia PR, Zaiman AL, Wigley FM, Girgis RE, Hassoun PM. Disproportionate elevation of N-terminal pro-brain natriuretic peptide in scleroderma-related pulmonary hypertension. The European Respiratory Journal. 35: 95-104. PMID 19643943 DOI: 10.1183/09031936.00074309  1
2009 Moens AL, Leyton-Mange JS, Niu X, Yang R, Cingolani O, Arkenbout EK, Champion HC, Bedja D, Gabrielson KL, Chen J, Xia Y, Hale AB, Channon KM, Halushka MK, Barker N, et al. Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. Journal of Molecular and Cellular Cardiology. 47: 576-85. PMID 19766235 DOI: 10.1016/J.Yjmcc.2009.06.005  1
2009 Champion HC, Michelakis ED, Hassoun PM. Comprehensive invasive and noninvasive approach to the right ventricle-pulmonary circulation unit: state of the art and clinical and research implications. Circulation. 120: 992-1007. PMID 19752350 DOI: 10.1161/CIRCULATIONAHA.106.674028  1
2009 Kim JH, Bugaj LJ, Oh YJ, Bivalacqua TJ, Ryoo S, Soucy KG, Santhanam L, Webb A, Camara A, Sikka G, Nyhan D, Shoukas AA, Ilies M, Christianson DW, Champion HC, et al. Arginase inhibition restores NOS coupling and reverses endothelial dysfunction and vascular stiffness in old rats. Journal of Applied Physiology (Bethesda, Md. : 1985). 107: 1249-57. PMID 19661445 DOI: 10.1152/Japplphysiol.91393.2008  1
2009 Hemnes AR, Forfia PR, Champion HC. Assessment of pulmonary vasculature and right heart by invasive haemodynamics and echocardiography. International Journal of Clinical Practice. Supplement. 4-19. PMID 19624796 DOI: 10.1111/J.1742-1241.2009.02110.X  1
2009 Kittleson MM, Skojec DV, Wittstein IS, Champion HC, Judge DP, Barouch LA, Halushka M, Hare JM, Kasper EK, Russell SD. The change in B-type natriuretic peptide levels over time predicts significant rejection in cardiac transplant recipients. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 28: 704-9. PMID 19560699 DOI: 10.1016/J.Healun.2009.04.019  1
2009 Badesch DB, Champion HC, Sanchez MA, Hoeper MM, Loyd JE, Manes A, McGoon M, Naeije R, Olschewski H, Oudiz RJ, Torbicki A. Diagnosis and assessment of pulmonary arterial hypertension. Journal of the American College of Cardiology. 54: S55-66. PMID 19555859 DOI: 10.1016/J.Jacc.2009.04.011  1
2009 Ghofrani HA, Barst RJ, Benza RL, Champion HC, Fagan KA, Grimminger F, Humbert M, Simonneau G, Stewart DJ, Ventura C, Rubin LJ. Future perspectives for the treatment of pulmonary arterial hypertension. Journal of the American College of Cardiology. 54: S108-17. PMID 19555854 DOI: 10.1016/J.Jacc.2009.04.014  1
2009 Bivalacqua TJ, Musicki B, Hsu LL, Gladwin MT, Burnett AL, Champion HC. Establishment of a transgenic sickle-cell mouse model to study the pathophysiology of priapism. The Journal of Sexual Medicine. 6: 2494-504. PMID 19523035 DOI: 10.1111/J.1743-6109.2009.01359.X  1
2009 Thompson-Torgerson CS, Champion HC, Santhanam L, Harris ZL, Shoukas AA. Cyclohexanone contamination from extracorporeal circuits impairs cardiovascular function. American Journal of Physiology. Heart and Circulatory Physiology. 296: H1926-32. PMID 19411286 DOI: 10.1152/Ajpheart.00184.2009  1
2009 Weiss ES, Champion HC, Williams JA, Baumgartner WA, Shah AS. Long-acting oral phosphodiesterase inhibition preconditions against reperfusion injury in an experimental lung transplantation model. The Journal of Thoracic and Cardiovascular Surgery. 137: 1249-57. PMID 19379999 DOI: 10.1016/J.Jtcvs.2008.12.040  1
2009 Abraham J, Mudd JO, Kapur NK, Kapur N, Klein K, Champion HC, Wittstein IS. Stress cardiomyopathy after intravenous administration of catecholamines and beta-receptor agonists. Journal of the American College of Cardiology. 53: 1320-5. PMID 19358948 DOI: 10.1016/J.Jacc.2009.02.020  1
2009 Musicki B, Ross AE, Champion HC, Burnett AL, Bivalacqua TJ. Posttranslational modification of constitutive nitric oxide synthase in the penis. Journal of Andrology. 30: 352-62. PMID 19342700 DOI: 10.2164/Jandrol.108.006999  1
2009 Angelini DJ, Su Q, Yamaji-Kegan K, Fan C, Teng X, Hassoun PM, Yang SC, Champion HC, Tuder RM, Johns RA. Resistin-like molecule-beta in scleroderma-associated pulmonary hypertension. American Journal of Respiratory Cell and Molecular Biology. 41: 553-61. PMID 19251945 DOI: 10.1165/Rcmb.2008-0271Oc  1
2009 Mathai SC, Hummers LK, Champion HC, Wigley FM, Zaiman A, Hassoun PM, Girgis RE. Survival in pulmonary hypertension associated with the scleroderma spectrum of diseases: impact of interstitial lung disease. Arthritis and Rheumatism. 60: 569-77. PMID 19180517 DOI: 10.1002/Art.24267  1
2009 Fisher MR, Forfia PR, Chamera E, Housten-Harris T, Champion HC, Girgis RE, Corretti MC, Hassoun PM. Accuracy of Doppler echocardiography in the hemodynamic assessment of pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine. 179: 615-21. PMID 19164700 DOI: 10.1164/Rccm.200811-1691Oc  1
2009 Angelini DJ, Su Q, Yamaji-Kegan K, Fan C, Skinner JT, Champion HC, Crow MT, Johns RA. Hypoxia-induced mitogenic factor (HIMF/FIZZ1/RELMα) induces the vascular and hemodynamic changes of pulmonary hypertension American Journal of Physiology - Lung Cellular and Molecular Physiology. 296: L582-L593. PMID 19136574 DOI: 10.1152/Ajplung.90526.2008  1
2009 Sussan TE, Rangasamy T, Blake DJ, Malhotra D, El-Haddad H, Bedja D, Yates MS, Kombairaju P, Yamamoto M, Liby KT, Sporn MB, Gabrielson KL, Champion HC, Tuder RM, Kensler TW, et al. Targeting Nrf2 with the triterpenoid CDDO-imidazolide attenuates cigarette smoke-induced emphysema and cardiac dysfunction in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 250-5. PMID 19104057 DOI: 10.1073/Pnas.0804333106  1
2009 Bivalacqua TJ, Sussan TE, Gebska MA, Strong TD, Berkowitz DE, Biswal S, Burnett AL, Champion HC. Sildenafil inhibits superoxide formation and prevents endothelial dysfunction in a mouse model of secondhand smoke induced erectile dysfunction. The Journal of Urology. 181: 899-906. PMID 19095260 DOI: 10.1016/J.Juro.2008.10.062  1
2008 Tedford RJ, Hemnes AR, Russell SD, Wittstein IS, Mahmud M, Zaiman AL, Mathai SC, Thiemann DR, Hassoun PM, Girgis RE, Orens JB, Shah AS, Yuh D, Conte JV, Champion HC. PDE5A inhibitor treatment of persistent pulmonary hypertension after mechanical circulatory support. Circulation. Heart Failure. 1: 213-9. PMID 19808294 DOI: 10.1161/Circheartfailure.108.796789  1
2008 Zhang M, Koitabashi N, Nagayama T, Rambaran R, Feng N, Takimoto E, Koenke T, O'Rourke B, Champion HC, Crow MT, Kass DA. Expression, activity, and pro-hypertrophic effects of PDE5A in cardiac myocytes. Cellular Signalling. 20: 2231-6. PMID 18790048 DOI: 10.1016/J.Cellsig.2008.08.012  1
2008 Hemnes AR, Champion HC. Right heart function and haemodynamics in pulmonary hypertension. International Journal of Clinical Practice. Supplement. 11-9. PMID 18638171 DOI: 10.1111/J.1742-1241.2008.01812.X  1
2008 Heidecker B, Kasper EK, Wittstein IS, Champion HC, Breton E, Russell SD, Kittleson MM, Baughman KL, Hare JM. Transcriptomic biomarkers for individual risk assessment in new-onset heart failure. Circulation. 118: 238-46. PMID 18591436 DOI: 10.1161/CIRCULATIONAHA.107.756544  1
2008 Bivalacqua TJ, Guzzo TJ, Schaeffer EM, Gebska MA, Champion HC, Burnett AL, Gonzalgo ML. Application of Evicel to cavernous nerves of the rat does not influence erectile function in vivo. Urology. 72: 1169-73. PMID 18561990 DOI: 10.1016/J.Urology.2008.03.046  1
2008 Moens AL, Takimoto E, Tocchetti CG, Chakir K, Bedja D, Cormaci G, Ketner EA, Majmudar M, Gabrielson K, Halushka MK, Mitchell JB, Biswal S, Channon KM, Wolin MS, Alp NJ, ... ... Champion HC, et al. Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy. Circulation. 117: 2626-36. PMID 18474817 DOI: 10.1161/Circulationaha.107.737031  1
2008 Tankersley CG, Champion HC, Takimoto E, Gabrielson K, Bedja D, Misra V, El-Haddad H, Rabold R, Mitzner W. Exposure to inhaled particulate matter impairs cardiac function in senescent mice. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 295: R252-63. PMID 18448608 DOI: 10.1152/Ajpregu.00697.2007  1
2008 Moens AL, Vrints CJ, Claeys MJ, Timmermans JP, Champion HC, Kass DA. Mechanisms and potential therapeutic targets for folic acid in cardiovascular disease. American Journal of Physiology. Heart and Circulatory Physiology. 294: H1971-7. PMID 18375715 DOI: 10.1152/Ajpheart.91503.2007  1
2008 Moens AL, Champion HC, Claeys MJ, Tavazzi B, Kaminski PM, Wolin MS, Borgonjon DJ, Van Nassauw L, Haile A, Zviman M, Bedja D, Wuyts FL, Elsaesser RS, Cos P, Gabrielson KL, et al. High-dose folic acid pretreatment blunts cardiac dysfunction during ischemia coupled to maintenance of high-energy phosphates and reduces postreperfusion injury. Circulation. 117: 1810-9. PMID 18362233 DOI: 10.1161/Circulationaha.107.725481  1
2008 Forfia PR, Mathai SC, Fisher MR, Housten-Harris T, Hemnes AR, Champion HC, Girgis RE, Hassoun PM. Hyponatremia predicts right heart failure and poor survival in pulmonary arterial hypertension. American Journal of Respiratory and Critical Care Medicine. 177: 1364-9. PMID 18356560 DOI: 10.1164/Rccm.200712-1876Oc  1
2008 Grigoryev DN, Mathai SC, Fisher MR, Girgis RE, Zaiman AL, Housten-Harris T, Cheadle C, Gao L, Hummers LK, Champion HC, Garcia JG, Wigley FM, Tuder RM, Barnes KC, Hassoun PM. Identification of candidate genes in scleroderma-related pulmonary arterial hypertension. Translational Research : the Journal of Laboratory and Clinical Medicine. 151: 197-207. PMID 18355767 DOI: 10.1016/J.Trsl.2007.12.010  1
2008 Champion HC. The heart in scleroderma. Rheumatic Diseases Clinics of North America. 34: 181-90; viii. PMID 18329539 DOI: 10.1016/J.Rdc.2007.12.002  1
2008 Ryoo S, Gupta G, Benjo A, Lim HK, Camara A, Sikka G, Lim HK, Sohi J, Santhanam L, Soucy K, Tuday E, Baraban E, Ilies M, Gerstenblith G, Nyhan D, ... ... Champion HC, et al. Endothelial arginase II: a novel target for the treatment of atherosclerosis. Circulation Research. 102: 923-32. PMID 18309100 DOI: 10.1161/Circresaha.107.169573  1
2008 Strong TD, Gebska MA, Champion HC, Burnett AL, Bivalacqua TJ. Stem and endothelial progenitor cells in erection biology. International Journal of Impotence Research. 20: 243-54. PMID 18256677 DOI: 10.1038/Sj.Ijir.3901635  1
2008 Zaiman AL, Podowski M, Medicherla S, Gordy K, Xu F, Zhen L, Shimoda LA, Neptune E, Higgins L, Murphy A, Chakravarty S, Protter A, Sehgal PB, Champion HC, Tuder RM. Role of the TGF-beta/Alk5 signaling pathway in monocrotaline-induced pulmonary hypertension. American Journal of Respiratory and Critical Care Medicine. 177: 896-905. PMID 18202349 DOI: 10.1164/Rccm.200707-1083Oc  1
2008 Strong TD, Gebska MA, Burnett AL, Champion HC, Bivalacqua TJ. Endothelium-specific gene and stem cell-based therapy for erectile dysfunction. Asian Journal of Andrology. 10: 14-22. PMID 18087639 DOI: 10.1111/J.1745-7262.2008.00362.X  1
2008 Hemnes AR, Zaiman A, Champion HC. PDE5A inhibition attenuates bleomycin-induced pulmonary fibrosis and pulmonary hypertension through inhibition of ROS generation and RhoA/Rho kinase activation. American Journal of Physiology. Lung Cellular and Molecular Physiology. 294: L24-33. PMID 17965319 DOI: 10.1152/Ajplung.00245.2007  1
2008 Michelakis ED, Champion HC. Editors' Note: Pulmonary vascular diseases Circulation. 118: 1115-1116. DOI: 10.1161/Circulationaha.108.808303  1
2007 Soong TR, Barouch LA, Champion HC, Wigley FM, Halushka MK. New clinical and ultrastructural findings in hydroxychloroquine-induced cardiomyopathy--a report of 2 cases. Human Pathology. 38: 1858-63. PMID 18061791 DOI: 10.1016/J.Humpath.2007.06.013  1
2007 Nossaman BD, Bivalacqua TJ, Champion HC, Baber SR, Kadowitz PJ. Analysis of vasodilator responses to peroxynitrite in the hindlimb vascular bed of the cat. Journal of Cardiovascular Pharmacology. 50: 358-66. PMID 18049302 DOI: 10.1097/Fjc.0B013E31811242Cd  1
2007 Kass DA, Champion HC, Beavo JA. Phosphodiesterase type 5: expanding roles in cardiovascular regulation. Circulation Research. 101: 1084-95. PMID 18040025 DOI: 10.1161/Circresaha.107.162511  1
2007 Strong TD, Champion HC, Kadowitz PJ, Bivalacqua TJ. Reply: potential differentiation of human mesenchymal stem cell transplanted in rat corpus cavernosum toward endothelial or smooth muscle cells. International Journal of Impotence Research. 19: 530. PMID 17786157 DOI: 10.1038/Sj.Ijir.3901585  1
2007 Mahmud M, Champion HC. Right ventricular failure complicating heart failure: pathophysiology, significance, and management strategies. Current Cardiology Reports. 9: 200-8. PMID 17470333 DOI: 10.1007/Bf02938351  1
2007 Kass DA, Takimoto E, Nagayama T, Champion HC. Phosphodiesterase regulation of nitric oxide signaling. Cardiovascular Research. 75: 303-14. PMID 17467673 DOI: 10.1016/J.Cardiores.2007.02.031  1
2007 Kittleson MM, Bead V, Fradley M, St John ME, Champion HC, Kasper EK, Russell SD, Wittstein IS, Hare JM. Elevated uric acid levels predict allograft vasculopathy in cardiac transplant recipients. The Journal of Heart and Lung Transplantation : the Official Publication of the International Society For Heart Transplantation. 26: 498-503. PMID 17449420 DOI: 10.1016/J.Healun.2007.01.039  1
2007 Takimoto E, Belardi D, Tocchetti CG, Vahebi S, Cormaci G, Ketner EA, Moens AL, Champion HC, Kass DA. Compartmentalization of cardiac beta-adrenergic inotropy modulation by phosphodiesterase type 5. Circulation. 115: 2159-67. PMID 17420342 DOI: 10.1161/Circulationaha.106.643536  1
2007 Bivalacqua TJ, Kendirci M, Champion HC, Hellstrom WJG, Andersson KE, Hedlund P. Dysregulation of cGMP-dependent protein kinase 1 (PKG-1) impairs erectile function in diabetic rats: Influence of in vivo gene therapy of PKG1α Bju International. 99: 1488-1494. PMID 17355372 DOI: 10.1111/J.1464-410X.2007.06794.X  1
2007 Forfia PR, Lee M, Tunin RS, Mahmud M, Champion HC, Kass DA. Acute phosphodiesterase 5 inhibition mimics hemodynamic effects of B-type natriuretic peptide and potentiates B-type natriuretic peptide effects in failing but not normal canine heart. Journal of the American College of Cardiology. 49: 1079-88. PMID 17349888 DOI: 10.1016/J.Jacc.2006.08.066  1
2007 Kittleson MM, St John ME, Bead V, Champion HC, Kasper EK, Russell SD, Wittstein IS, Hare JM. Increased levels of uric acid predict haemodynamic compromise in patients with heart failure independently of B-type natriuretic peptide levels. Heart (British Cardiac Society). 93: 365-7. PMID 17322514 DOI: 10.1136/Hrt.2006.090845  1
2007 Girgis RE, Mozammel S, Champion HC, Li D, Peng X, Shimoda L, Tuder RM, Johns RA, Hassoun PM. Regression of chronic hypoxic pulmonary hypertension by simvastatin. American Journal of Physiology. Lung Cellular and Molecular Physiology. 292: L1105-10. PMID 17277047 DOI: 10.1152/Ajplung.00411.2006  1
2007 Kapur NK, Deming CB, Kapur S, Bian C, Champion HC, Donahue JK, Kass DA, Rade JJ. Hemodynamic modulation of endocardial thromboresistance. Circulation. 115: 67-75. PMID 17190863 DOI: 10.1161/Circulationaha.106.640698  1
2007 Hsu LL, Champion HC, Campbell-Lee SA, Bivalacqua TJ, Manci EA, Diwan BA, Schimel DM, Cochard AE, Wang X, Schechter AN, Noguchi CT, Gladwin MT. Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability. Blood. 109: 3088-98. PMID 17158223 DOI: 10.1182/Blood-2006-08-039438  1
2007 Bivalacqua TJ, Liu T, Musicki B, Champion HC, Burnett AL. Endothelial Nitric Oxide Synthase Keeps Erection Regulatory Function Balance in the Penis European Urology. 51: 1732-1740. PMID 17113219 DOI: 10.1016/J.Eururo.2006.10.061  1
2007 Mathai SC, Girgis RE, Fisher MR, Champion HC, Housten-Harris T, Zaiman A, Hassoun PM. Additon of sildenafil to bosentan monotherapy in pulmonary arterial hypertension European Respiratory Journal. 29: 469-475. PMID 17079256 DOI: 10.1183/09031936.00081706  1
2007 Bivalacqua TJ, Burnett AL, Hellstrom WJ, Champion HC. Overexpression of arginase in the aged mouse penis impairs erectile function and decreases eNOS activity: influence of in vivo gene therapy of anti-arginase. American Journal of Physiology. Heart and Circulatory Physiology. 292: H1340-51. PMID 17071735 DOI: 10.1152/Ajpheart.00121.2005  1
2007 Bivalacqua TJ, Deng W, Kendirci M, Usta MF, Robinson C, Taylor BK, Murthy SN, Champion HC, Hellstrom WJ, Kadowitz PJ. Mesenchymal stem cells alone or ex vivo gene modified with endothelial nitric oxide synthase reverse age-associated erectile dysfunction. American Journal of Physiology. Heart and Circulatory Physiology. 292: H1278-90. PMID 17071732 DOI: 10.1152/Ajpheart.00685.2006  1
2007 Maslov MY, Chacko VP, Stuber M, Moens AL, Kass DA, Champion HC, Weiss RG. Altered high-energy phosphate metabolism predicts contractile dysfunction and subsequent ventricular remodeling in pressure-overload hypertrophy mice American Journal of Physiology - Heart and Circulatory Physiology. 292: H387-H391. PMID 16963614 DOI: 10.1152/Ajpheart.00737.2006  1
2007 Bilchick KC, Duncan JG, Ravi R, Takimoto E, Champion HC, Gao WD, Stull LB, Kass DA, Murphy AM. Heart failure-associated alterations in troponin I phosphorylation impair ventricular relaxation-afterload and force-frequency responses and systolic function. American Journal of Physiology. Heart and Circulatory Physiology. 292: H318-25. PMID 16936010 DOI: 10.1152/Ajpheart.00283.2006  1
2006 Burnett AL, Bivalacqua TJ, Champion HC, Musicki B. Feasibility of the use of phosphodiesterase type 5 inhibitors in a pharmacologic prevention program for recurrent priapism. The Journal of Sexual Medicine. 3: 1077-84. PMID 17100941 DOI: 10.1111/J.1743-6109.2006.00333.X  1
2006 Kendirci M, Teloken PE, Champion HC, Hellstrom WJ, Bivalacqua TJ. Gene therapy for erectile dysfunction: fact or fiction? European Urology. 50: 1208-22. PMID 16950560 DOI: 10.1016/J.Eururo.2006.08.007  1
2006 Fisher MR, Mathai SC, Champion HC, Girgis RE, Housten-Harris T, Hummers L, Krishnan JA, Wigley F, Hassoun PM. Clinical differences between idiopathic and scleroderma-related pulmonary hypertension Arthritis and Rheumatism. 54: 3043-3050. PMID 16947776 DOI: 10.1002/Art.22069  1
2006 Yamaji-Kegan K, Su Q, Angelini DJ, Champion HC, Johns RA. Hypoxia-induced mitogenic factor has proangiogenic and proinflammatory effects in the lung via VEGF and VEGF receptor-2 American Journal of Physiology - Lung Cellular and Molecular Physiology. 291: L1159-L1168. PMID 16891392 DOI: 10.1152/Ajplung.00168.2006  1
2006 Forfia PR, Fisher MR, Mathai SC, Housten-Harris T, Hemnes AR, Borlaug BA, Chamera E, Corretti MC, Champion HC, Abraham TP, Girgis RE, Hassoun PM. Tricuspid annular displacement predicts survival in pulmonary hypertension American Journal of Respiratory and Critical Care Medicine. 174: 1034-1041. PMID 16888289 DOI: 10.1164/Rccm.200604-547Oc  1
2006 Elrod JW, Duranski MR, Langston W, Greer JJ, Tao L, Dugas TR, Kevil CG, Champion HC, Lefer DJ. eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling. Circulation Research. 99: 78-85. PMID 16763164 DOI: 10.1161/01.Res.0000231306.03510.77  1
2006 Hemnes AR, Champion HC. Sildenafil, a PDE5 inhibitor, in the treatment of pulmonary hypertension Expert Review of Cardiovascular Therapy. 4: 293-300. PMID 16716091 DOI: 10.1586/14779072.4.3.293  1
2006 Burnett AL, Bivalacqua TJ, Champion HC, Musicki B. Long-term oral phosphodiesterase 5 inhibitor therapy alleviates recurrent priapism Urology. 67: 1043-1048. PMID 16698365 DOI: 10.1016/J.Urology.2005.11.045  1
2006 Hurt KJ, Sezen SF, Champion HC, Crone JK, Palese MA, Huang PL, Sawa A, Luo X, Musicki B, Snyder SH, Burnett AL. Alternatively spliced neuronal nitric oxide synthase mediates penile erection. Proceedings of the National Academy of Sciences of the United States of America. 103: 3440-3. PMID 16488973 DOI: 10.1073/Pnas.0511326103  1
2006 Jin L, Liu T, Lagoda GA, Champion HC, Bivalacqua TJ, Burnett AL. Elevated RhoA/Rho-kinase activity in the aged rat penis: Mechanism for age-associated erectile dysfunction Faseb Journal. 20: 536-538. PMID 16396994 DOI: 10.1096/Fj.05-4232Fje  1
2006 Schulman SP, Becker LC, Kass DA, Champion HC, Terrin ML, Forman S, Ernst KV, Kelemen MD, Townsend SN, Capriotti A, Hare JM, Gerstenblith G. L-arginine therapy in acute myocardial infarction: the Vascular Interaction With Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. Jama. 295: 58-64. PMID 16391217 DOI: 10.1001/Jama.295.1.58  1
2006 White AR, Ryoo S, Li D, Champion HC, Steppan J, Wang D, Nyhan D, Shoukas AA, Hare JM, Berkowitz DE. Knockdown of arginase I restores NO signaling in the vasculature of old rats. Hypertension. 47: 245-51. PMID 16380531 DOI: 10.1161/01.Hyp.0000198543.34502.D7  1
2006 Champion HC. Erectile dysfunction and cardiovascular disease: Carrots, sticks, and better men's health Advanced Studies in Medicine. 6: 163-170.  1
2005 Bivalacqua TJ, Usta MF, Kendirci M, Pradhan L, Alvarez X, Champion HC, Kadowitz PJ, Hellstrom WJ. Superoxide anion production in the rat penis impairs erectile function in diabetes: influence of in vivo extracellular superoxide dismutase gene therapy. The Journal of Sexual Medicine. 2: 187-97; discussion 1. PMID 16422885 DOI: 10.1111/J.1743-6109.2005.20228_1.X  1
2005 Bivalacqua TJ, Musicki B, Usta MF, Champion HC, Kadowitz PJ, Burnett AL, Hellstrom WJ. Endothelial nitric oxide synthase gene therapy for erectile dysfunction. Current Pharmaceutical Design. 11: 4059-67. PMID 16378511 DOI: 10.2174/138161205774913345  1
2005 Miranda KM, Katori T, Torres de Holding CL, Thomas L, Ridnour LA, McLendon WJ, Cologna SM, Dutton AS, Champion HC, Mancardi D, Tocchetti CG, Saavedra JE, Keefer LK, Houk KN, Fukuto JM, et al. Comparison of the NO and HNO donating properties of diazeniumdiolates: primary amine adducts release HNO in Vivo. Journal of Medicinal Chemistry. 48: 8220-8. PMID 16366603 DOI: 10.1021/Jm050151I  1
2005 Musicki B, Champion HC, Becker RE, Kramer MF, Liu T, Sezen SF, Burnett AL. In vivo analysis of chronic phosphodiesterase-5 inhibition with sildenafil in penile erectile tissues: No tachyphylaxis effect Journal of Urology. 174: 1493-1496. PMID 16145478 DOI: 10.1097/01.Ju.0000173006.47623.2C  1
2005 Nagoshi T, Matsui T, Aoyama T, Leri A, Anversa P, Li L, Ogawa W, Del Monte F, Gwathmey JK, Grazette L, Hemmings B, Kass DA, Champion HC, Rosenzweig A. PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury Journal of Clinical Investigation. 115: 2128-2138. PMID 16007268 DOI: 10.1172/Jci23073  1
2005 Wilson A, Zhou W, Champion HC, Alber S, Tang ZL, Kennel S, Watkins S, Huang L, Pitt B, Li S. Targeted delivery of oligodeoxynucleotides to mouse lung endothelial cells in vitro and in vivo. Molecular Therapy : the Journal of the American Society of Gene Therapy. 12: 510-8. PMID 15953766 DOI: 10.1016/J.Ymthe.2005.04.005  1
2005 Girgis RE, Champion HC, Diette GB, Johns RA, Permutt S, Sylvester JT. Decreased exhaled nitric oxide in pulmonary arterial hypertension: Response to Bosentan therapy American Journal of Respiratory and Critical Care Medicine. 172: 352-357. PMID 15879413 DOI: 10.1164/Rccm.200412-1684Oc  1
2005 Maseri A, Kurisu S, Inoue I, Kawagoe T, Kadhiravan T, Wittstein IS, Champion HC. Myocardial stunning due to sudden emotional stress [1] (multiple letters) New England Journal of Medicine. 352: 1923-1925. PMID 15877319 DOI: 10.1056/NEJM200505053521816  1
2005 Musicki B, Champion HC, Becker RE, Liu T, Kramer MF, Burnett AL. Erection capability is potentiated by long-term sildenafil treatment: Role of blood flow-induced endothelial nitric-oxide synthase phosphorylation Molecular Pharmacology. 68: 226-232. PMID 15851653 DOI: 10.1124/Mol.104.010678  1
2005 Takimoto E, Champion HC, Li M, Ren S, Rodriguez ER, Tavazzi B, Lazzarino G, Paolocci N, Gabrielson KL, Wang Y, Kass DA. Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. The Journal of Clinical Investigation. 115: 1221-31. PMID 15841206 DOI: 10.1172/Jci21968  1
2005 Champion HC. Targeting protein phosphatase 1 in heart failure Circulation Research. 96: 708-710. PMID 15831821 DOI: 10.1161/01.Res.0000164359.95588.25  1
2005 Wittstein IS, Thiemann DR, Lima JA, Baughman KL, Schulman SP, Gerstenblith G, Wu KC, Rade JJ, Bivalacqua TJ, Champion HC. Neurohumoral features of myocardial stunning due to sudden emotional stress. The New England Journal of Medicine. 352: 539-48. PMID 15703419 DOI: 10.1056/Nejmoa043046  1
2005 Sohn RH, Deming CB, Johns DC, Champion HC, Bian C, Gardner K, Rade JJ. Regulation of endothelial thrombomodulin expression by inflammatory cytokines is mediated by activation of nuclear factor-kappa B Blood. 105: 3910-3917. PMID 15677570 DOI: 10.1182/Blood-2004-03-0928  1
2005 Champion HC, Bivalacqua TJ, Takimoto E, Kass DA, Burnett AL. Phosphodiesterase-5A dysregulation in penile erectile tissue is a mechanism of priapism Proceedings of the National Academy of Sciences of the United States of America. 102: 1661-1666. PMID 15668387 DOI: 10.1073/Pnas.0407183102  1
2005 Takimoto E, Champion HC, Li M, Belardi D, Ren S, Rodriguez ER, Bedja D, Gabrielson KL, Wang Y, Kass DA. Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. Nature Medicine. 11: 214-22. PMID 15665834 DOI: 10.1038/Nm1175  1
2005 Segers P, Georgakopoulos D, Afanasyeva M, Champion HC, Judge DP, Millar HD, Verdonck P, Kass DA, Stergiopulos N, Westerhof N. Conductance catheter-based assessment of arterial input impedance, arterial function, and ventricular-vascular interaction in mice. American Journal of Physiology. Heart and Circulatory Physiology. 288: H1157-64. PMID 15604134 DOI: 10.1152/Ajpheart.00414.2004  1
2005 Takimoto E, Champion HC, Belardi D, Moslehi J, Mongillo M, Mergia E, Montrose DC, Isoda T, Aufiero K, Zaccolo M, Dostmann WR, Smith CJ, Kass DA. cGMP catabolism by phosphodiesterase 5A regulates cardiac adrenergic stimulation by NOS3-dependent mechanism Circulation Research. 96: 100-109. PMID 15576651 DOI: 10.1161/01.Res.0000152262.22968.72  1
2004 Bivalacqua TJ, Deng W, Champion HC, Hellstrom WJ, Kadowitz PJ. Gene therapy techniques for the delivery of endothelial nitric oxide synthase to the corpora cavernosa for erectile dysfunction. Methods in Molecular Biology (Clifton, N.J.). 279: 173-85. PMID 15199245 DOI: 10.1385/1-59259-807-2:173  1
2004 Bivalacqua TJ, Champion HC, Usta MF, Cellek S, Chitaley K, Webb RC, Lewis RL, Mills TM, Hellstrom WJ, Kadowitz PJ. RhoA/Rho-kinase suppresses endothelial nitric oxide synthase in the penis: a mechanism for diabetes-associated erectile dysfunction. Proceedings of the National Academy of Sciences of the United States of America. 101: 9121-6. PMID 15184671 DOI: 10.1073/Pnas.0400520101  1
2004 Champion HC, Kass DA. Calcium handler mishandles heart Nature Medicine. 10: 239-240. PMID 14991046 DOI: 10.1038/Nm0304-239  1
2004 Bivalacqua TJ, Usta MF, Champion HC, Leungwattanakij S, Dabisch PA, McNamara DB, Kadowitz PJ, Hellstrom WJ. Effect of combination endothelial nitric oxide synthase gene therapy and sildenafil on erectile function in diabetic rats. International Journal of Impotence Research. 16: 21-9. PMID 14963467 DOI: 10.1038/Sj.Ijir.3901054  1
2004 Champion HC, Georgakopoulos D, Takimoto E, Isoda T, Wang Y, Kass DA. Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3. Circulation Research. 94: 657-63. PMID 14752030 DOI: 10.1161/01.Res.0000119323.79644.20  1
2004 Nossaman BD, Dabisch PA, Liles JT, Baber SR, Champion HC, Kaye AD, Feng CJ, Anwar M, Bivalacqua TJ, Santiago JA, De Witt BJ, Kadowitz PJ. Peroxynitrite does not impair pulmonary and systemic vascular responses. Journal of Applied Physiology (Bethesda, Md. : 1985). 96: 455-62. PMID 14715677 DOI: 10.1152/Japplphysiol.01159.2002  1
2004 Bivalacqua TJ, Usta MF, Champion HC, Deng W, Kadowitz PJ, Hellstrom WJ. 1417: Mesenchymal Stem Cells Alone or Modified with ENOS Restore Erectile Function in the Aged Rat: Cell-Based Gene Therapy for Erectile Dysfunction Journal of Urology. 171: 373-373. DOI: 10.1016/S0022-5347(18)38642-7  0.32
2003 Champion HC, Georgakopoulos D, Haldar S, Wang L, Wang Y, Kass DA. Robust adenoviral and adeno-associated viral gene transfer to the in vivo murine heart: application to study of phospholamban physiology. Circulation. 108: 2790-7. PMID 14638552 DOI: 10.1161/01.Cir.0000096487.88897.9B  1
2003 Bivalacqua TJ, Usta MF, Champion HC, Kadowitz PJ, Hellstrom WJ. Endothelial dysfunction in erectile dysfunction: role of the endothelium in erectile physiology and disease. Journal of Andrology. 24: S17-37. PMID 14581492 DOI: 10.1002/J.1939-4640.2003.Tb02743.X  1
2003 Berkowitz DE, White R, Li D, Minhas KM, Cernetich A, Kim S, Burke S, Shoukas AA, Nyhan D, Champion HC, Hare JM. Arginase reciprocally regulates nitric oxide synthase activity and contributes to endothelial dysfunction in aging blood vessels. Circulation. 108: 2000-6. PMID 14517171 DOI: 10.1161/01.Cir.0000092948.04444.C7  1
2003 Baber SR, Champion HC, Bivalacqua TJ, Hyman AL, Kadowitz PJ. Role of cyclooxygenase-2 in the generation of vasoactive prostanoids in the rat pulmonary and systemic vascular beds. Circulation. 108: 896-901. PMID 12900348 DOI: 10.1161/01.Cir.0000084536.87322.Bb  1
2003 Teng X, Li D, Champion HC, Johns RA. FIZZ1/RELMα, a novel hypoxia-induced mitogenic factor in lung with vasoconstrictive and angiogenic properties Circulation Research. 92: 1065-1067. PMID 12714564 DOI: 10.1161/01.Res.0000073999.07698.33  1
2003 Paolocci N, Katori T, Champion HC, St John ME, Miranda KM, Fukuto JM, Wink DA, Kass DA. Positive inotropic and lusitropic effects of HNO/NO- in failing hearts: independence from beta-adrenergic signaling. Proceedings of the National Academy of Sciences of the United States of America. 100: 5537-42. PMID 12704230 DOI: 10.1073/Pnas.0937302100  1
2003 Bivalacqua TJ, Usta MF, Champion HC, Adams D, Namara DB, Abdel-Mageed AB, Kadowitz PJ, Hellstrom WJ. Gene transfer of endothelial nitric oxide synthase partially restores nitric oxide synthesis and erectile function in streptozotocin diabetic rats. The Journal of Urology. 169: 1911-7. PMID 12686872 DOI: 10.1097/01.Ju.0000051881.14239.4A  1
2003 Champion HC, Skaf MW, Hare JM. Role of nitric oxide in the pathophysiology of heart failure Heart Failure Reviews. 8: 35-46. PMID 12652158 DOI: 10.1023/A:1022142904202  1
2003 Leungwattanakij S, Bivalacqua TJ, Usta MF, Yang DY, Hyun JS, Champion HC, Abdel-Mageed AB, Hellstrom WJ. Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum. Journal of Andrology. 24: 239-45. PMID 12634311 DOI: 10.1002/J.1939-4640.2003.Tb02668.X  1
2003 Champion HC, Bivalacqua TJ, Pierce RL, Murphy WA, Coy DH, Hyman AL, Kadowitz PJ. Responses to human CGRP, ADM, and PAMP in human thymic arteries. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 284: R531-7. PMID 12529288 DOI: 10.1152/Ajpregu.00337.2002  1
2003 Bivalacqua TJ, Armstrong JS, Biggerstaff J, Abdel-Mageed AB, Kadowitz PJ, Hellstrom WJ, Champion HC. Gene transfer of extracellular SOD to the penis reduces O2-* and improves erectile function in aged rats. American Journal of Physiology. Heart and Circulatory Physiology. 284: H1408-21. PMID 12505874 DOI: 10.1152/Ajpheart.00770.2002  1
2002 Bivalacqual TJ, Champion HC, Hellstrom WJG. Implications of nitric oxide synthase isoforms in the pathophysiology of Peyronie's disease International Journal of Impotence Research. 14: 345-352. PMID 12454685 DOI: 10.1038/Sj.Ijir.3900872  1
2002 Chitaley K, Bivalacqua TJ, Champion HC, Usta MF, Hellstrom WJG, Mills TM, Clinton Webb R. Adeno-associated viral gene transfer of dominant negative RhoA enhances erectile function in rats Biochemical and Biophysical Research Communications. 298: 427-432. PMID 12413959 DOI: 10.1016/S0006-291X(02)02458-0  1
2002 Champion HC, Bivalacqua TJ, Greenberg SS, Giles TD, Hyman AL, Kadowitz PJ. Adenoviral gene transfer of endothelial nitric-oxide synthase (eNOS) partially restores normal pulmonary arterial pressure in eNOS-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. 99: 13248-53. PMID 12237402 DOI: 10.1073/Pnas.182225899  1
2002 Bivalacqua TJ, Champion HC, Shah MK, De Witt BJ, Inscho EW, Kadowitz PJ. Comparative responses to alpha,beta-methylene-ATP in cat pulmonary, mesenteric, and hindquarter vascular beds. Journal of Applied Physiology (Bethesda, Md. : 1985). 93: 1287-95. PMID 12235027 DOI: 10.1152/Japplphysiol.00262.2002  1
2002 Bivalacqua TJ, Hyman AL, Kadowitz PJ, Paolocci N, Kass DA, Champion HC. Role of calcitonin gene-related peptide (CGRP) in chronic hypoxia-induced pulmonary hypertension in the mouse. Influence of gene transfer in vivo. Regulatory Peptides. 108: 129-33. PMID 12220736 DOI: 10.1016/S0167-0115(02)00100-3  1
2002 Bivalacqua TJ, Champion HC, Lambert DG, Kadowitz PJ. Vasodilator responses to adenosine and hyperemia are mediated by A(1) and A(2) receptors in the cat vascular bed. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 282: R1696-709. PMID 12010752 DOI: 10.1152/Ajpregu.00394.2001  1
2002 Ortiz LA, Champion HC, Lasky JA, Gambelli F, Gozal E, Hoyle GW, Beasley MB, Hyman AL, Friedman M, Kadowitz PJ. Enalapril protects mice from pulmonary hypertension by inhibiting TNF-mediated activation of NF-kappaB and AP-1. American Journal of Physiology. Lung Cellular and Molecular Physiology. 282: L1209-21. PMID 12003776 DOI: 10.1152/Ajplung.00144.2001  1
2002 Champion HC, Bivalacqua TJ, Zadina JE, Kastin AJ, Hyman AL, Kadowitz PJ. Role of nitric oxide in mediating vasodilator responses to opioid peptides in the rat. Clinical and Experimental Pharmacology & Physiology. 29: 229-32. PMID 11906489 DOI: 10.1046/J.1440-1681.2002.03634.X  1
2002 Bivalacqua TJ, Hellstrom WJG, Kadowitz PJ, Champion HC, Burnett AL. Increased expression of arginase II in human diabetic corpus cavernosum: In diabetic-associated erectile dysfunction International Journal of Impotence Research. 14: 204. DOI: 10.1038/sj.ijir.3900849  1
2001 Bivalacqua TJ, Champion HC, Hyman AL, McNamara DB, Kadowitz PJ. Analysis of responses to angiotensin II in the mouse. Journal of the Renin-Angiotensin-Aldosterone System : Jraas. 2: S48-S53. PMID 28095236 DOI: 10.1177/14703203010020010801  1
2001 Shah MK, Champion HC, Bivalacqua TJ, Kadowitz PJ. Differential responses to ATPgammaS in the mesenteric and hindlimb vascular bed of the cat. Life Sciences. 69: 2561-71. PMID 11693263 DOI: 10.1016/S0024-3205(01)01336-4  1
2001 Bivalacqua TJ, Champion HC, Abdel-Mageed AB, Kadowitz PJ, Hellstrom WJ. Gene transfer of prepro-calcitonin gene-related peptide restores erectile function in the aged rat. Biology of Reproduction. 65: 1371-7. PMID 11673252 DOI: 10.1095/Biolreprod65.5.1371  1
2001 Shah MK, Bivalacqua TJ, Champion HC, Kadowitz PJ. Vasodilator responses to ATP and UTP are cAMP dependent in the mesenteric vascular bed of the cat. Journal of Cardiovascular Pharmacology and Therapeutics. 6: 287-95. PMID 11584335 DOI: 10.1177/107424840100600309  1
2001 Champion HC, Pierce RL, Bivalacqua TJ, Murphy WA, Coy DH, Kadowitz PJ. Analysis of responses to hAmylin, hCGRP, and hADM in isolated resistance arteries from the mesenteric vascular bed of the rat. Peptides. 22: 1427-34. PMID 11514024 DOI: 10.1016/S0196-9781(01)00482-X  1
2001 Bivalacqua TJ, Champion HC, De Witt BJ, Saavedra JE, Hrabie JA, Keefer LK, Kadowitz PJ. Analysis of vasodilator responses to novel nitric oxide donors in the hindquarters vascular bed of the cat. Journal of Cardiovascular Pharmacology. 38: 120-9. PMID 11444495 DOI: 10.1097/00005344-200107000-00013  1
2001 Sikka SC, Champion HC, Bivalacqua TJ, Estrada LS, Wang R, Rajasekaran M, Aggarwal BB, Hellstrom WJG. Role of genitourinary inflammation in infertility: Synergistic effect of lipopolysaccharide and interferon-γ on human spermatozoa International Journal of Andrology. 24: 136-141. PMID 11380702 DOI: 10.1046/J.1365-2605.2001.00279.X  1
2001 Bivalacqua TJ, Hellstrom WJ, Kadowitz PJ, Champion HC. Increased expression of arginase II in human diabetic corpus cavernosum: in diabetic-associated erectile dysfunction. Biochemical and Biophysical Research Communications. 283: 923-7. PMID 11350073 DOI: 10.1006/Bbrc.2001.4874  1
2001 Bivalacqua TJ, Champion HC, Leungwattanakij S, Yang DY, Hyun JS, Abdel-Mageed AB, Sikka SC, Kadowitz PJ, Hellstrom WJ. Evaluation of nitric oxide synthase and arginase in the induction of a Peyronie's-like condition in the rat. Journal of Andrology. 22: 497-506. PMID 11330651 DOI: 10.1002/J.1939-4640.2001.Tb02207.X  1
2001 Doherty PC, Bivalacqua TJ, Champion HC, Kadowitz PJ, Greenwood-Van Meerveld B, Berzetei-Gurske I, Hellstrom WJ. Direct effects of selective type 5 phosphodiesterase inhibitors alone or with other vasodilators on the erectile response in cats. The Journal of Urology. 165: 1004-9. PMID 11176530 DOI: 10.1016/S0022-5347(05)66592-5  1
2001 Champion HC, Hare JM. Emerging therapeutic targets in nitric oxide-dependent cardiac disease Expert Opinion On Therapeutic Targets. 5: 547-556. DOI: 10.1517/14728222.5.5.547  1
2001 Bivalacqua TJ, Champion HC, Hyman AL, McNamara DB, Kadowitz PJ. Analysis of responses to angiotensin II in the mouse Jraas - Journal of the Renin-Angiotensin-Aldosterone System. 2: S48-S53.  1
2000 Mazzocchi G, Rossi GP, Malendowicz LK, Champion HC, Nussdorfer GG. Endothelin-1[1-31], acting as an ETA-receptor selective agonist, stimulates proliferation of cultured rat zona glomerulosa cells Febs Letters. 487: 194-198. PMID 11150508 DOI: 10.1016/S0014-5793(00)02352-8  1
2000 Bivalacqua TJ, Champion HC, Hellstrom WJ, Kadowitz PJ. Pharmacotherapy for erectile dysfunction. Trends in Pharmacological Sciences. 21: 484-9. PMID 11121838 DOI: 10.1016/S0165-6147(00)01587-X  1
2000 Hugghins SY, Champion HC, Cheng G, Kadowitz PJ, Jeter JR. Vasorelaxant responses to endomorphins, nociceptin, albuterol, and adrenomedullin in isolated rat aorta Life Sciences. 67: 471-476. PMID 11003057 DOI: 10.1016/S0024-3205(00)00631-7  1
2000 Bivalacqua TJ, Champion HC, Mehta YS, Abdel-Mageed AB, Sikka SC, Ignarro LJ, Kadowitz PJ, Hellstrom WJ. Adenoviral gene transfer of endothelial nitric oxide synthase (eNOS) to the penis improves age-related erectile dysfunction in the rat. International Journal of Impotence Research. 12: S8-17. PMID 11002394 DOI: 10.1038/Sj.Ijir.3900556  1
2000 Shah MK, Hugghins SY, Champion HC, Bivalacqua TJ. New therapies for treating hypertension: what every physician should know The Journal of the Louisiana State Medical Society : Official Organ of the Louisiana State Medical Society. 152: 334-344. PMID 10986845  1
2000 De Witt BJ, Garrison EA, Champion HC, Kadowitz PJ. L-163,491 is a partial angiotensin AT1 receptor agonist in the hindquarters vascular bed of the cat European Journal of Pharmacology. 404: 213-219. PMID 10980281 DOI: 10.1016/S0014-2999(00)00612-9  1
2000 Champion HC, Kadowitz PJ. Vasodilator responses to ATP and UTP are not dependent on nitric oxide release, K+(ATP) channel activation, or the release of vasodilator prostaglandins in the hindlimb vascular bed of the cat Canadian Journal of Physiology and Pharmacology. 78: 612-621. PMID 10958161 DOI: 10.1139/Y00-021  1
2000 Bivalacqua TJ, Champion HC, Purohit SK, Murphy WA, Coy DH, Kadowitz PJ, Hellstrom WJ. Nitric oxide-mediated erectile effects of galantide but not galanin in vivo. Nitric Oxide : Biology and Chemistry / Official Journal of the Nitric Oxide Society. 4: 94-102. PMID 10835289 DOI: 10.1006/Niox.2000.0274  1
2000 Andreis PG, Markowska A, Champion HC, Mazzocchi G, Malendowicz LK, Nussdorfer GG. Adrenomedullin enhances cell proliferation and deoxyribonucleic acid synthesis in rat adrenal zona glomerulosa: Receptor subtype involved and signaling mechanism Endocrinology. 141: 2098-2104. PMID 10830296 DOI: 10.1210/Endo.141.6.7508  1
2000 Bivalacqua TJ, Diner EK, Novak TE, Vohra Y, Sikka SC, Champion HC, Kadowitz PJ, Hellstrom WJ. A rat model of Peyronie's disease associated with a decrease in erectile activity and an increase in inducible nitric oxide synthase protein expression. The Journal of Urology. 163: 1992-8. PMID 10799245 DOI: 10.1016/S0022-5347(05)67616-1  1
2000 Champion HC, Bivalacqua TJ, Toyoda K, Heistad DD, Hyman AL, Kadowitz PJ. In vivo gene transfer of prepro-calcitonin gene-related peptide to the lung attenuates chronic hypoxia-induced pulmonary hypertension in the mouse. Circulation. 101: 923-30. PMID 10694533 DOI: 10.1161/01.Cir.101.8.923  1
2000 Champion HC, Villnave DJ, Tower A, Kadowitz PJ, Hyman AL. A novel right-heart catheterization technique for in vivo measurement of vascular responses in lungs of intact mice American Journal of Physiology - Heart and Circulatory Physiology. 278: H8-H15. PMID 10644578 DOI: 10.1152/Ajpheart.2000.278.1.H8  1
1999 Mazzocchi G, Albertin G, Andreis PG, Neri G, Malendowicz LK, Champion HC, Bahçelioglu M, Kadowitz PJ, Nussdorfer GG. Distribution, functional role, and signaling mechanism of adrenomedullin receptors in the rat adrenal gland Peptides. 20: 1479-1487. PMID 10698124 DOI: 10.1016/S0196-9781(99)00159-X  1
1999 Champion HC, Bivalacqua TJ, Zadina JE, Kastin AJ, Kadowitz PJ. Vasodilator responses to the endomorphin peptides, but not nociceptin/OFQ, are mediated by nitric oxide release. Annals of the New York Academy of Sciences. 897: 165-72. PMID 10676445 DOI: 10.1111/J.1749-6632.1999.Tb07888.X  1
1999 Bivalacqua TJ, Champion HC, Wang R, Kadowitz PJ, Doherty PC, Hellstrom WJ. Feline penile erection induced by transurethral administration of sodium nitroprusside. Urological Research. 27: 432-6. PMID 10651131 DOI: 10.1007/S002400050132  1
1999 Champion HC, Nussdorfer GG, Kadowitz PJ. Structure-activity relationships of adrenomedullin in the circulation and adrenal gland Regulatory Peptides. 85: 1-8. PMID 10588445 DOI: 10.1016/S0167-0115(99)00025-7  1
1999 Bivalacqua TJ, Dalal A, Champion HC, Kadowitz PJ. Role of AT(1) receptors and autonomic nervous system in mediating acute pressor responses to ANG II in anesthetized mice. The American Journal of Physiology. 277: E838-47. PMID 10567010 DOI: 10.1152/Ajpendo.1999.277.5.E838  1
1999 Bivalacqua TJ, Champion HC, Rajasekaran M, Sikka SC, Kadowitz PJ, Doherty PC, Hellstrom WJ. Potentiation of erectile response and cAMP accumulation by combination of prostaglandin E1 and rolipram, a selective inhibitor of the type 4 phosphodiesterase (PDE 4). The Journal of Urology. 162: 1848-55. PMID 10524946 DOI: 10.1016/S0022-5347(05)68249-3  1
1999 Champion HC, Bivalacqua TJ, Lambert DG, Abassi RA, Kadowitz PJ. Analysis of vasoconstrictor responses to histamine in the hindlimb vascular bed of the rabbit. The American Journal of Physiology. 277: R1179-87. PMID 10516260 DOI: 10.1152/Ajpregu.1999.277.4.R1179  1
1999 Champion HC, Bivalacqua TJ, Hyman AL, Ignarro LJ, Hellstrom WJ, Kadowitz PJ. Gene transfer of endothelial nitric oxide synthase to the penis augments erectile responses in the aged rat. Proceedings of the National Academy of Sciences of the United States of America. 96: 11648-52. PMID 10500231 DOI: 10.1073/Pnas.96.20.11648  1
1999 Champion HC, Bivalacqua TJ, D'Souza FM, Ortiz LA, Jeter JR, Toyoda K, Heistad DD, Hyman AL, Kadowitz PJ. Gene transfer of endothelial nitric oxide synthase to the lung of the mouse in vivo. Effect on agonist-induced and flow-mediated vascular responses. Circulation Research. 84: 1422-32. PMID 10381895 DOI: 10.1161/01.Res.84.12.1422  1
1999 Belloni AS, Rossi GP, Andreis PG, Aragona F, Champion HC, Kadowitz PJ, Murphy WA, Coy DH, Nussdorfer GG. Proadrenomedullin N-terminal 20 peptide (PAMP), acting through PAMP(12- 20)-sensitive receptors, inhibits Ca2+-dependent, agonist-stimulated secretion of human adrenal glands Hypertension. 33: 1185-1189. PMID 10334809 DOI: 10.1161/01.Hyp.33.5.1185  1
1999 Champion HC, Bivalacqua TJ, Wang R, Kadowitz PJ, Keefer LK, Saavedra JE, Hrabie JA, Doherty PC, Hellstrom WJ. Induction of penile erection by intracavernosal and transurethral administration of novel nitric oxide donors in the cat. The Journal of Urology. 161: 2013-9. PMID 10332492 DOI: 10.1016/S0022-5347(05)68875-1  1
1999 Belloni AS, Andreis PG, Meneghelli V, Champion HC, Kadowitz PJ, Coy DH, Murphy WA, Nussdorfer GG. Adrenomedullin and calcitonin gene-related peptide (CGRP) interact with a common receptor of the CGRP1 subtype in the human adrenal zona glomerulosa Endocrine Research. 25: 29-34. PMID 10098591 DOI: 10.1080/07435809909066127  1
1999 Champion HC, Kadowitz PJ. Vasodepressor responses to [D-Ala2]-endomorphin 2 (TAPP) are mediated by an L-NAME-sensitive mechanism in the rat Journal of Cardiovascular Pharmacology. 33: 280-284. PMID 10028937 DOI: 10.1097/00005344-199902000-00015  1
1998 Champion HC, Czapla MA, Kadowitz PJ. Responses to angiotensin peptides are mediated by ATreceptors in the rat. American Journal of Physiology. Endocrinology and Metabolism. 274: E115-E123. PMID 29590986 DOI: 10.1152/ajpendo.1998.274.1.E115  1
1998 Champion HC, Kadowitz PJ. d-[Ala]endomorphin 2 and endomorphin 2 have nitric oxide-dependent vasodilator activity in rats. American Journal of Physiology. Heart and Circulatory Physiology. 274: H1690-H1697. PMID 29586504 DOI: 10.1152/ajpheart.1998.274.5.H1690  1
1998 Hyman AL, Hao Q, Tower A, Kadowitz PJ, Champion HC, Gumusel B, Lippton H. Novel catheterization technique for the in vivo measurement of pulmonary vascular responses in rats. American Journal of Physiology. Heart and Circulatory Physiology. 274: H1218-H1229. PMID 29586014 DOI: 10.1152/ajpheart.1998.274.4.H1218  1
1998 Gumusel B, Hao Q, Hyman AL, Kadowitz PJ, Champion HC, Chang JK, Mehta JL, Lippton H. Analysis of responses to adrenomedullin-(13-52) in the pulmonary vascular bed of rats. American Journal of Physiology. Heart and Circulatory Physiology. 274: H1255-H1263. PMID 29586004 DOI: 10.1152/ajpheart.1998.274.4.H1255  1
1998 Champion HC, Bivalacqua TJ, Rauchwarger A, McWilliams SM, McNamara DB, Kadowitz PJ. Analysis of Vasodepressor Responses to Nociceptin and Nociceptin Analogs in the Systemic Vascular Bed of the Anesthetized Rabbit In Vivo. Journal of Cardiovascular Pharmacology and Therapeutics. 3: 247-252. PMID 10684505 DOI: 10.1177/107424849800300308  1
1998 Belloni AS, Andreis PG, Rossi GP, Champion HC, Kadowitz PJ, Murphy WA, Coy DH, Nussdorfer GG. Structure-activity relationships of adrenomedullin in the adrenal gland Endocrine Research. 24: 729-730. PMID 9888567 DOI: 10.3109/07435809809032677  1
1998 Champion HC, Pierce RL, Kadowitz PJ. Nociceptin, a novel endogenous ligand for the ORL1 receptor, dilates isolated resistance arteries from the rat Regulatory Peptides. 78: 69-74. PMID 9879748 DOI: 10.1016/S0167-0115(98)00117-7  1
1998 Belloni AS, Andreis PG, Rossi GP, Mingrino A, Champion HC, Kadowitz PJ, Murphy WA, Coy DH, Nussdorfer GG. Inhibitory effect of adrenomedullin (ADM) on the aldosterone response of human adrenocortical cells to angiotensin-II: Role of ADM(22-52)-sensitive receptors Life Sciences. 63: 2313-2321. PMID 9877221 DOI: 10.1016/S0024-3205(98)00520-7  1
1998 Champion HC, Bivalacqua TJ, Wang R, Hellstrom WJ, Kadowitz PJ. [Tyr1]-nociceptin and nociceptin have similar naloxone-insensitive erectile activity in the cat. Journal of Andrology. 19: 747-53. PMID 9876026 DOI: 10.1002/J.1939-4640.1998.Tb02084.X  1
1998 Champion HC, Bivalacqua TJ, Friedman DE, Zadina JE, Kastin AJ, Kadowitz PJ. Nitric oxide release mediates vasodilator responses to endomorphin 1 but not nociceptin/OFQ in the hindquarters vascular bed of the rat. Peptides. 19: 1595-602. PMID 9864068 DOI: 10.1016/S0196-9781(98)00110-7  1
1998 Belloni AS, Meneghelli V, Champion HC, Murray WA, Coy DH, Kadowitz PJ, Nussdorfer GG. Autoradiographic evidence that zona glomerulosa and capsular vessels of the human adrenal cortex are provided with different subtypes of adrenomedullin receptors Peptides. 19: 1581-1584. PMID 9864066 DOI: 10.1016/S0196-9781(98)00111-9  1
1998 Bivalacqua TJ, Rajasekaran M, Champion HC, Wang R, Sikka SC, Kadowitz PJ, Hellstrom WJ. The influence of castration on pharmacologically induced penile erection in the cat. Journal of Andrology. 19: 551-7. PMID 9796614 DOI: 10.1002/J.1939-4640.1998.Tb02056.X  1
1998 Champion HC, Bivalacqua TJ, Lambert DG, McWilliams SM, Zadina JE, Kastin AJ, Kadowitz PJ. Endomorphin 1 and 2, the endogenous mu-opioid agonists, produce biphasic changes in systemic arterial pressure in the cat. Life Sciences. 63: PL131-6. PMID 9740318 DOI: 10.1016/S0024-3205(98)00335-X  1
1998 Champion HC, Kadowitz PJ. Influence of nimodipine on vasoconstrictor responses in the hindquarters vascular bed of the cat Journal of Pharmacy and Pharmacology. 50: 673-680. PMID 9680080 DOI: 10.1111/J.2042-7158.1998.Tb06904.X  1
1998 McNamara DB, Champion HC, Kadowitz PJ. Pharmacologic management of peripheral vascular disease Surgical Clinics of North America. 78: 447-464. PMID 9673656 DOI: 10.1016/S0039-6109(05)70325-X  1
1998 Champion HC, Zadina JE, Kastin AJ, Kadowitz PJ. Endomorphin 1 and 2 have vasodepressor activity in the anesthetized mouse. Peptides. 19: 925-9. PMID 9663459 DOI: 10.1016/S0196-9781(98)00026-6  1
1998 Champion HC, Estrada LS, Estrada LN, Filep JG, Kadowitz PJ. Analysis of effects of bosentan (Ro 47-0203), a nonpeptide endothelin ET(A)/ET(B) receptor antagonist, in the hind-limb vascular bed of the cat Canadian Journal of Physiology and Pharmacology. 76: 141-147. PMID 9635152 DOI: 10.1139/Y98-001  1
1998 Lambert DG, Champion HC, Kadowitz PJ. Inhibitory effects of candesartan on responses to angiotensin peptides in the hindquarters vascular bed of the cat Canadian Journal of Physiology and Pharmacology. 76: 133-140. PMID 9635151 DOI: 10.1139/Y98-002  1
1998 Gumusel B, Hao Q, Hyman AL, Kadowitz PJ, Champion HC, Chang JK, Mehta JL, Lippton H. Analysis of responses to adrenomedullin-(13-52) in the pulmonary vascular bed of rats. The American Journal of Physiology. 274: H1255-63. PMID 9575929 DOI: 10.1152/Ajpheart.1998.274.4.H1255  1
1998 Hyman AL, Hao Q, Tower A, Kadowitz PJ, Champion HC, Gumusel B, Lippton H. Novel catheterization technique for the in vivo measurement of pulmonary vascular responses in rats. The American Journal of Physiology. 274: H1218-29. PMID 9575925 DOI: 10.1152/Ajpheart.1998.274.4.H1218  1
1998 Champion HC, Kadowitz PJ. R-(-)-alpha-methyl-histamine has nitric oxide-mediated vasodilator activity in the mesenteric vascular bed of the cat. European Journal of Pharmacology. 343: 209-16. PMID 9570469 DOI: 10.1016/S0014-2999(97)01525-2  0.56
1998 Czapla MA, Champion HC, Zadina JE, Kastin AJ, Hackler L, Ge LJ, Kadowitz PJ. Endomorphin 1 and 2, endogenous mu-opioid agonists, decrease systemic arterial pressure in the rat. Life Sciences. 62: PL175-9. PMID 9519803 DOI: 10.1016/S0024-3205(98)00048-4  1
1998 Champion HC, Czapla MA, Kadowitz PJ. Responses to angiotensin peptides are mediated by AT1 receptors in the rat. The American Journal of Physiology. 274: E115-23. PMID 9458756 DOI: 10.1152/Ajpendo.1998.274.1.E115  1
1998 Champion HC, Kadowitz PJ. [Tyr1]-nociceptin has naloxone-insensitive vasodilator activity in the hindquarters vascular bed of the rat. Life Sciences. 61: PL 403-8. PMID 9416781 DOI: 10.1016/S0024-3205(97)01013-8  0.52
1998 Champion HC, Kadowitz PJ. D-[Ala2]endomorphin 2 and endomorphin 2 have nitric oxide-dependent vasodilator activity in rats American Journal of Physiology - Heart and Circulatory Physiology. 43: H1690-H1697. DOI: 10.1152/Ajpheart.1998.274.5.H1690  1
1998 Lambert DG, Champion HC, Kadowitz PJ. Inhibitory effects of candesartan on responses to angiotensin peptides in the hindquarters vascular bed of the cat Canadian Journal of Physiology and Pharmacology. 76: 133-140. DOI: 10.1139/y98-002  0.36
1997 Garrison EA, Champion HC, Kadowitz PJ. [Pro,d-Ala]angiotensin I has rapid onset vasoconstrictor activity in the cat. American Journal of Physiology. Endocrinology and Metabolism. 273: E1059-E1064. PMID 29585406 DOI: 10.1152/ajpendo.1997.273.6.E1059  1
1997 Garrison EA, Champion HC, Kadowitz PJ. [Pro11,D-Ala12]angiotensin I has rapid onset vasoconstrictor activity in the cat. The American Journal of Physiology. 273: E1059-64. PMID 9435519 DOI: 10.1152/Ajpendo.1997.273.6.E1059  1
1997 Champion HC, Zadina JE, Kastin AJ, Kadowitz PJ. The endogenous mu-opioid agonists, endomorphin 1 and 2, have vasodilator activity in the hindquarters vascular bed of the rat. Life Sciences. 61: PL 409-15. PMID 9416782 DOI: 10.1016/S0024-3205(97)01029-1  1
1997 Champion HC, Akers DL, Santiago JA, Lambert DG, McNamara DB, Kadowitz PJ. Analysis of responses to human synthetic adrenomedullin and calcitonin gene-related peptides in the hindlimb vascular bed of the cat. Molecular and Cellular Biochemistry. 176: 5-11. PMID 9406138 DOI: 10.1023/A:1006888107952  1
1997 Estrada LS, Champion HC, Wang R, Rajasekaran M, Hellstrom WJ, Aggarwal B, Sikka SC. Effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human sperm motility, viability and motion parameters. International Journal of Andrology. 20: 237-42. PMID 9401827 DOI: 10.1046/J.1365-2605.1997.00062.X  0.6
1997 Czapla MA, Champion HC, Kadowitz PJ. Decreases in systemic arterial and hindquarters perfusion pressure in response to nociceptin are not inhibited by naloxone in the rat. Peptides. 18: 1197-200. PMID 9396061 DOI: 10.1016/S0196-9781(97)00178-2  1
1997 Champion HC, Zadina JE, Kastin AJ, Hackler L, Ge LJ, Kadowitz PJ. Endomorphin 1 and 2, endogenous ligands for the mu-opioid receptor, decrease cardiac output, and total peripheral resistance in the rat. Peptides. 18: 1393-7. PMID 9392842 DOI: 10.1016/S0196-9781(97)00210-6  1
1997 Champion HC, Santiago JA, Czapla MA, Bivalacqua TJ, Ilgenfritz C, Kadowitz PJ. Comparison of responses to T-kinin and bradykinin in the mesenteric vascular bed of the cat. Peptides. 18: 1357-64. PMID 9392837 DOI: 10.1016/S0196-9781(97)00197-6  1
1997 Champion HC, Kadowitz PJ. Analysis of the effects of candesartan in the mesenteric vascular bed of the cat. Hypertension (Dallas, Tex. : 1979). 30: 1260-6. PMID 9369285 DOI: 10.1161/01.Hyp.30.5.1260  0.52
1997 Czapla MA, Champion HC, Kadowitz PJ. Nociceptin, an endogenous ligand for the ORL1 receptor, has vasodilator activity in the hindquarters vascular bed of the rat. Peptides. 18: 793-5. PMID 9285926 DOI: 10.1016/S0196-9781(97)00014-4  1
1997 Champion HC, Kadowitz PJ. NO release and the opening of K+ATP channels mediate vasodilator responses to histamine in the cat. The American Journal of Physiology. 273: H928-37. PMID 9277512 DOI: 10.1152/Ajpheart.1997.273.2.H928  0.56
1997 Champion HC, Lambert DG, McWilliams SM, Shah MK, Murphy WA, Coy DH, Kadowitz PJ. Comparison of responses to rat and human adrenomedullin in the hindlimb vascular bed of the cat. Regulatory Peptides. 70: 161-5. PMID 9272628 DOI: 10.1016/S0167-0115(97)01003-3  0.32
1997 Champion HC, Kadowitz PJ. Vasodilator responses to acetylcholine, bradykinin, and substance P are mediated by a TEA-sensitive mechanism. The American Journal of Physiology. 273: R414-22. PMID 9249580 DOI: 10.1152/Ajpregu.1997.273.1.R414  0.48
1997 Champion HC, Czapla MA, Kadowitz PJ. Nociceptin, an endogenous ligand for the ORL1 receptor, decreases cardiac output and total peripheral resistance in the rat. Peptides. 18: 729-32. PMID 9213368 DOI: 10.1016/S0196-9781(97)00003-X  1
1997 Champion HC, Czapla MA, Friedman DE, Lambert DG, Murphy WA, Coy DH, Kadowitz PJ. Tone-dependent vasodilator responses to proadrenomedullin NH2-terminal 20 peptide in the hindquarters vascular bed of the rat. Peptides. 18: 513-9. PMID 9210169 DOI: 10.1016/S0196-9781(96)00348-8  1
1997 Champion HC, Zadina JE, Kastin AJ, Hackler L, Ge LJ, Kadowitz PJ. The endogenous mu-opioid receptor agonists endomorphins 1 and 2 have novel hypotensive activity in the rabbit. Biochemical and Biophysical Research Communications. 235: 567-70. PMID 9207197 DOI: 10.1006/Bbrc.1997.6843  1
1997 Champion HC, Kadowitz PJ. [Tyr1]-nociceptin, a novel nociceptin analog, decreases systemic arterial pressure by a naloxone-insensitive mechanism in the rat. Biochemical and Biophysical Research Communications. 234: 309-12. PMID 9177265 DOI: 10.1006/Bbrc.1997.6629  0.68
1997 Champion HC, Murphy WA, Coy DH, Kadowitz PJ. Proadrenomedullin NH2-terminal 20 peptide has direct vasodilator activity in the cat. The American Journal of Physiology. 272: R1047-54. PMID 9140000 DOI: 10.1152/Ajpregu.1997.272.4.R1047  0.36
1997 Champion HC, Friedman DE, Lambert DG, Murphy WA, Coy DH, Kadowitz PJ. Adrenomedullin (16-31) has pressor activity in the rat but not the cat Peptides. 18: 133-136. PMID 9114462 DOI: 10.1016/S0196-9781(96)00251-3  1
1997 Champion HC, Kadowitz PJ. Nociceptin, an endogenous ligand for the ORL1 receptor, has novel hypotensive activity in the rat. Life Sciences. 60: PL 241-5. PMID 9096263 DOI: 10.1016/S0024-3205(97)00087-8  0.56
1997 Santiago JA, Champion HC, Kadowitz PJ. T-kinin has endothelium-dependent vasodilator activity in the cat. The American Journal of Physiology. 272: H1491-8. PMID 9087628 DOI: 10.1152/Ajpheart.1997.272.3.H1491  0.6
1997 Fry RC, Champion HC, Lawrence TC, Murphy WA, Coy DH, Kadowitz PJ. Proadrenomedullin NH2-terminal peptide (PAMP)(12-20) has vasodepressor activity in the rat and cat. Life Sciences. 60: PL161-7. PMID 9064471 DOI: 10.1016/S0024-3205(97)00007-6  1
1997 Champion HC, Santiago JA, Murphy WA, Coy DH, Kadowitz PJ. Adrenomedullin-(22-52) antagonizes vasodilator responses to CGRP but not adrenomedullin in the cat. The American Journal of Physiology. 272: R234-42. PMID 9039014 DOI: 10.1152/Ajpregu.1997.272.1.R234  0.4
1997 Champion HC, Wang R, Santiago JA, Murphy WA, Coy DH, Kadowitz PJ, Hellstrom WJG. Comparison of Responses to Adrenomedullin and Calcitonin Gene‐Related Peptide in the Feline Erection Model Journal of Andrology. 18: 513-521. DOI: 10.1002/J.1939-4640.1997.Tb01966.X  1
1996 DeWitt BJ, Cheng DY, McMahon TJ, Marrone JR, Champion HC, Kadowitz PJ. Effects of U-37883A, a vascular selective K(ATP)/+ channel antagonist, in the pulmonary and hindlimb circulation American Journal of Physiology - Lung Cellular and Molecular Physiology. 271. PMID 8997262 DOI: 10.1152/Ajplung.1996.271.6.L924  1
1996 Champion HC, Santiago JA, Garrison EA, Cheng DY, Coy DH, Murphy WA, Ascuitto RJ, Ross-Ascuitto NT, Mcnamara DB, Kadowitz PJ. Analysis of cardiovascular responses to PACAP-27, PACAP-38, and vasoactive intestinal polypeptide Annals of the New York Academy of Sciences. 805: 429-442. PMID 8993422 DOI: 10.1111/J.1749-6632.1996.Tb17502.X  1
1996 Champion HC, Erickson CC, Simoneaux ML, Bivalacqua TJ, Murphy WA, Coy DH, Kadowitz PJ. Proadrenomedullin NH2-terminal 20 peptide has cAMP-mediated vasodilator activity in the mesenteric vascular bed of the cat. Peptides. 17: 1379-87. PMID 8971935 DOI: 10.1016/S0196-9781(96)00240-9  1
1996 Champion HC, Fry RC, Murphy WA, Coy DH, Kadowitz PJ. Catecholamine release mediates pressor effects of adrenomedullin-(15- 22) in the rat Hypertension. 28: 1041-1046. PMID 8952594 DOI: 10.1161/01.Hyp.28.6.1041  1
1996 Champion HC, Garrison EA, Estrada LS, Potter JM, Kadowitz PJ. Analysis of responses to angiotensin I and angiotensin I-(3-10) in the mesenteric vascular bed of the cat. European Journal of Pharmacology. 309: 251-9. PMID 8874148 DOI: 10.1016/0014-2999(96)00355-X  1
1995 Santiago JA, Garrison EA, Champion HC, Smith RE, Del Rio O, Kadowitz PJ. Analysis of responses to kallidin, DABK, and DAK in feline hindlimb vascular bed. The American Journal of Physiology. 269: H2057-64. PMID 8594917 DOI: 10.1152/Ajpheart.1995.269.6.H2057  1
1995 Santiago JA, Garrison E, Purnell WL, Smith RE, Champion HC, Coy DH, Murphy WA, Kadowitz PJ. Comparison of responses to adrenomedullin and adrenomedullin analogs in the mesenteric vascular bed of the cat. European Journal of Pharmacology. 272: 115-8. PMID 7713143 DOI: 10.1016/0014-2999(94)00693-2  1
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