| Year |
Citation |
Score |
| 2023 |
Collins JE, Lee JW, Rocamora F, Saggu GS, Wendt KL, Pasaje CFA, Smick S, Santos NM, Paes R, Jiang T, Mittal N, Luth MR, Chin T, Chang H, McLellan JL, ... ... Winzeler EA, et al. Antiplasmodial peptaibols act through membrane directed mechanisms. Cell Chemical Biology. PMID 37995692 DOI: 10.1016/j.chembiol.2023.10.025 |
0.751 |
|
| 2023 |
Coonahan E, Gage H, Chen D, Noormahomed EV, Buene TP, Mendes de Sousa I, Akrami K, Chambal L, Schooley RT, Winzeler EA, Cowell AN. Whole-genome surveillance identifies markers of drug resistance and novel genomic regions under selection in Mozambique. Mbio. e0176823. PMID 37750720 DOI: 10.1128/mbio.01768-23 |
0.821 |
|
| 2023 |
Mandt REK, Luth MR, Tye MA, Mazitschek R, Ottilie S, Winzeler EA, Lafuente-Monasterio MJ, Gamo FJ, Wirth DF, Lukens AK. Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance. Elife. 12. PMID 37737220 DOI: 10.7554/eLife.85023 |
0.792 |
|
| 2023 |
Siqueira-Neto JL, Wicht KJ, Chibale K, Burrows JN, Fidock DA, Winzeler EA. Antimalarial drug discovery: progress and approaches. Nature Reviews. Drug Discovery. PMID 37652975 DOI: 10.1038/s41573-023-00772-9 |
0.307 |
|
| 2023 |
Tilley L, Xie S, Wang Y, Morton C, Metcalfe R, Dogovski C, Pasaje CF, Dunn E, Luth M, Kumpornsin K, Istvan E, Park J, Fairhurst K, Yeo T, Yildirim O, ... ... Winzeler E, et al. Reaction hijacking inhibition of Plasmodium falciparum asparagine tRNA synthetase. Research Square. PMID 37546892 DOI: 10.21203/rs.3.rs-3198291/v1 |
0.786 |
|
| 2023 |
Kümpornsin K, Kochakarn T, Yeo T, Okombo J, Luth MR, Hoshizaki J, Rawat M, Pearson RD, Schindler KA, Mok S, Park H, Uhlemann AC, Jana GP, Maity BC, Laleu B, ... ... Winzeler EA, et al. Generation of a mutator parasite to drive resistome discovery in Plasmodium falciparum. Nature Communications. 14: 3059. PMID 37244916 DOI: 10.1038/s41467-023-38774-1 |
0.791 |
|
| 2023 |
Mittal N, Davis C, McLean P, Calla J, Godinez-Macias KP, Gardner A, Healey D, Orjuela-Sanchez P, Ottilie S, Chong Y, Gibson C, Winzeler EA. Human nuclear hormone receptor activity contributes to malaria parasite liver stage development. Cell Chemical Biology. 30: 486-498.e7. PMID 37172592 DOI: 10.1016/j.chembiol.2023.04.011 |
0.834 |
|
| 2023 |
Xie S, Griffin MDW, Winzeler EA, Ribas de Pouplana L, Tilley L. Targeting Aminoacyl tRNA Synthetases for Antimalarial Drug Development. Annual Review of Microbiology. PMID 37018842 DOI: 10.1146/annurev-micro-032421-121210 |
0.404 |
|
| 2023 |
Bopp S, Pasaje CFA, Summers RL, Magistrado-Coxen P, Schindler KA, Corpas-Lopez V, Yeo T, Mok S, Dey S, Smick S, Nasamu AS, Demas AR, Milne R, Wiedemar N, Corey V, ... ... Winzeler EA, et al. Potent acyl-CoA synthetase 10 inhibitors kill Plasmodium falciparum by disrupting triglyceride formation. Nature Communications. 14: 1455. PMID 36927839 DOI: 10.1038/s41467-023-36921-2 |
0.858 |
|
| 2023 |
Bohmer MJ, Wang J, Istvan ES, Luth MR, Collins JE, Huttlin EL, Wang L, Mittal N, Hao M, Kwiatkowski NP, Gygi SP, Chakrabarti R, Deng X, Goldberg DE, Winzeler EA, et al. Human Polo-like Kinase Inhibitors as Antiplasmodials. Acs Infectious Diseases. PMID 36919909 DOI: 10.1021/acsinfecdis.3c00025 |
0.755 |
|
| 2023 |
Istvan ES, Guerra F, Abraham M, Huang KS, Rocamora F, Zhao H, Xu L, Pasaje C, Kumpornsin K, Luth MR, Cui H, Yang T, Palomo Diaz S, Gomez-Lorenzo MG, Qahash T, ... ... Winzeler EA, et al. Cytoplasmic isoleucyl tRNA synthetase as an attractive multistage antimalarial drug target. Science Translational Medicine. 15: eadc9249. PMID 36888694 DOI: 10.1126/scitranslmed.adc9249 |
0.857 |
|
| 2023 |
Nguyen W, Dans MG, Currie I, Awalt JK, Bailey BL, Lumb C, Ngo A, Favuzza P, Palandri J, Ramesh S, Penington J, Jarman KE, Mukherjee P, Chakraborty A, Maier AG, ... ... Winzeler EA, et al. 7--Substituted-3-oxadiazole Quinolones with Potent Antimalarial Activity Target the Cytochrome Complex. Acs Infectious Diseases. PMID 36853190 DOI: 10.1021/acsinfecdis.2c00607 |
0.411 |
|
| 2023 |
Imlay LS, Lawong AK, Gahalawat S, Kumar A, Xing C, Mittal N, Wittlin S, Churchyard A, Niederstrasser H, Crespo-Fernandez B, Posner BA, Gamo FJ, Baum J, Winzeler EA, Laleu B, et al. Fast-Killing Tyrosine Amide (()-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (CARL). Acs Infectious Diseases. PMID 36763526 DOI: 10.1021/acsinfecdis.2c00527 |
0.42 |
|
| 2023 |
Almaliti J, Fajtová P, Calla J, LaMonte GM, Feng M, Rocamora F, Ottilie S, Glukhov E, Boura E, Suhandynata RT, Momper JD, Gilson MK, Winzeler EA, Gerwick WH, O'Donoghue AJ. Development of Potent and Highly Selective Epoxyketone-based Plasmodium Proteasome Inhibitors. Chemistry (Weinheim An Der Bergstrasse, Germany). PMID 36617500 DOI: 10.1002/chem.202203958 |
0.823 |
|
| 2022 |
Arendse LB, Murithi JM, Qahash T, Pasaje CFA, Godoy LC, Dey S, Gibhard L, Ghidelli-Disse S, Drewes G, Bantscheff M, Lafuente-Monasterio MJ, Fienberg S, Wambua L, Gachuhi S, Coertzen D, ... ... Winzeler EA, et al. The anticancer human mTOR inhibitor sapanisertib potently inhibits multiple kinases and life cycle stages. Science Translational Medicine. 14: eabo7219. PMID 36260689 DOI: 10.1126/scitranslmed.abo7219 |
0.787 |
|
| 2022 |
Laleu B, Rubiano K, Yeo T, Hallyburton I, Anderson M, Crespo-Fernandez B, Gamo FJ, Antonova-Koch Y, Orjuela-Sanchez P, Wittlin S, Jana GP, Maity BC, Chenu E, Duffy J, Sjö P, ... ... Winzeler E, et al. Exploring a Tetrahydroquinoline Antimalarial Hit from the Medicines for Malaria Pathogen Box and the Identification of its Mode of Resistance as PfeEF2. Chemmedchem. PMID 36129427 DOI: 10.1002/cmdc.202200393 |
0.452 |
|
| 2022 |
Tye MA, Payne NC, Johansson C, Singh K, Santos SA, Fagbami L, Pant A, Sylvester K, Luth MR, Marques S, Whitman M, Mota MM, Winzeler EA, Lukens AK, Derbyshire ER, et al. Elucidating the path to Plasmodium prolyl-tRNA synthetase inhibitors that overcome halofuginone resistance. Nature Communications. 13: 4976. PMID 36008486 DOI: 10.1038/s41467-022-32630-4 |
0.785 |
|
| 2022 |
Xie SC, Metcalfe RD, Dunn E, Morton CJ, Huang SC, Puhalovich T, Du Y, Wittlin S, Nie S, Luth MR, Ma L, Kim MS, Pasaje CFA, Kumpornsin K, Giannangelo C, ... ... Winzeler EA, et al. Reaction hijacking of tyrosine tRNA synthetase as a new whole-of-life-cycle antimalarial strategy. Science (New York, N.Y.). 376: 1074-1079. PMID 35653481 DOI: 10.1126/science.abn0611 |
0.753 |
|
| 2022 |
Beutler N, Pholcharee T, Oyen D, Flores-Garcia Y, MacGill RS, Garcia E, Calla J, Parren M, Yang L, Volkmuth W, Locke E, Regules JA, Dutta S, Emerling D, Early AM, ... ... Winzeler E, et al. A novel CSP C-terminal epitope targeted by an antibody with protective activity against Plasmodium falciparum. Plos Pathogens. 18: e1010409. PMID 35344575 DOI: 10.1371/journal.ppat.1010409 |
0.777 |
|
| 2022 |
Ottilie S, Luth MR, Hellemann E, Goldgof GM, Vigil E, Kumar P, Cheung AL, Song M, Godinez-Macias KP, Carolino K, Yang J, Lopez G, Abraham M, Tarsio M, LeBlanc E, ... ... Winzeler EA, et al. Adaptive laboratory evolution in S. cerevisiae highlights role of transcription factors in fungal xenobiotic resistance. Communications Biology. 5: 128. PMID 35149760 DOI: 10.1038/s42003-022-03076-7 |
0.822 |
|
| 2021 |
Xie SC, Metcalfe RD, Mizutani H, Puhalovich T, Hanssen E, Morton CJ, Du Y, Dogovski C, Huang SC, Ciavarri J, Hales P, Griffin RJ, Cohen LH, Chuang BC, Wittlin S, ... ... Winzeler EA, et al. Design of proteasome inhibitors with oral efficacy in vivo against and selectivity over the human proteasome. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34548400 DOI: 10.1073/pnas.2107213118 |
0.315 |
|
| 2021 |
Forte B, Ottilie S, Plater A, Campo B, Dechering KJ, Gamo FJ, Goldberg DE, Istvan ES, Lee M, Lukens AK, McNamara CW, Niles JC, Okombo J, Pasaje CFA, Siegel MG, ... ... Winzeler EA, et al. Prioritization of Molecular Targets for Antimalarial Drug Discovery. Acs Infectious Diseases. PMID 34523908 DOI: 10.1021/acsinfecdis.1c00322 |
0.664 |
|
| 2021 |
Ellis KM, Lucantoni L, Chavchich M, Abraham M, De Paoli A, Luth MR, Zeeman AM, Delves MJ, Terán FS, Straschil U, Baum J, Kocken CH, Ralph SA, Winzeler EA, Avery VM, et al. The novel bis-1,2,4-triazine MIPS-0004373 demonstrates rapid and potent activity against all blood stages of the malaria parasite. Antimicrobial Agents and Chemotherapy. AAC0031121. PMID 34460304 DOI: 10.1128/AAC.00311-21 |
0.834 |
|
| 2021 |
Summers RL, Pasaje CFA, Pisco JP, Striepen J, Luth MR, Kumpornsin K, Carpenter EF, Munro JT, Lin, Plater A, Punekar AS, Shepherd AM, Shepherd SM, Vanaerschot M, Murithi JM, ... ... Winzeler EA, et al. Chemogenomics identifies acetyl-coenzyme A synthetase as a target for malaria treatment and prevention. Cell Chemical Biology. PMID 34348113 DOI: 10.1016/j.chembiol.2021.07.010 |
0.805 |
|
| 2021 |
Murithi JM, Deni I, Pasaje CFA, Okombo J, Bridgford JL, Gnädig NF, Edwards RL, Yeo T, Mok S, Burkhard AY, Coburn-Flynn O, Istvan ES, Sakata-Kato T, Gomez-Lorenzo MG, Cowell AN, ... ... Winzeler EA, et al. The Plasmodium falciparum ABC transporter ABCI3 confers parasite strain-dependent pleiotropic antimalarial drug resistance. Cell Chemical Biology. PMID 34233174 DOI: 10.1016/j.chembiol.2021.06.006 |
0.827 |
|
| 2021 |
Palmer MJ, Deng X, Watts S, Krilov G, Gerasyuto A, Kokkonda S, El Mazouni F, White J, White KL, Striepen J, Bath J, Schindler KA, Yeo T, Shackleford DM, Mok S, ... ... Winzeler EA, et al. Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series. Journal of Medicinal Chemistry. PMID 33876936 DOI: 10.1021/acs.jmedchem.1c00173 |
0.343 |
|
| 2021 |
Rocamora F, Gupta P, Istvan ES, Luth MR, Carpenter EF, Kümpornsin K, Sasaki E, Calla J, Mittal N, Carolino K, Owen E, Llinás M, Ottilie S, Goldberg DE, Lee MCS, ... Winzeler EA, et al. PfMFR3: A Multidrug-Resistant Modulator in . Acs Infectious Diseases. PMID 33715347 DOI: 10.1021/acsinfecdis.0c00676 |
0.848 |
|
| 2021 |
Yang T, Ottilie S, Istvan ES, Godinez-Macias KP, Lukens AK, Baragaña B, Campo B, Walpole C, Niles JC, Chibale K, Dechering KJ, Llinás M, Lee MCS, Kato N, Wyllie S, ... ... Winzeler EA, et al. MalDA, Accelerating Malaria Drug Discovery. Trends in Parasitology. PMID 33648890 DOI: 10.1016/j.pt.2021.01.009 |
0.683 |
|
| 2021 |
Lawong A, Gahalawat S, Okombo J, Striepen J, Yeo T, Mok S, Deni I, Bridgford JL, Niederstrasser H, Zhou A, Posner B, Wittlin S, Gamo FJ, Crespo B, Churchyard A, ... ... Winzeler E, et al. Novel Antimalarial Tetrazoles and Amides Active against the Hemoglobin Degradation Pathway in . Journal of Medicinal Chemistry. PMID 33620219 DOI: 10.1021/acs.jmedchem.0c02022 |
0.445 |
|
| 2021 |
Le Manach C, Dam J, Woodland JG, Kaur G, Khonde LP, Brunschwig C, Njoroge M, Wicht KJ, Horatscheck A, Paquet T, Boyle GA, Gibhard L, Taylor D, Lawrence N, Yeo T, ... ... Winzeler EA, et al. Identification and Profiling of a Novel Diazaspiro[3.4]octane Chemical Series Active against Multiple Stages of the Human Malaria Parasite and Optimization Efforts. Journal of Medicinal Chemistry. PMID 33573376 DOI: 10.1021/acs.jmedchem.1c00034 |
0.427 |
|
| 2021 |
Dorjsuren D, Eastman RT, Wicht KJ, Jansen D, Talley DC, Sigmon BA, Zakharov AV, Roncal N, Girvin AT, Antonova-Koch Y, Will PM, Shah P, Sun H, Klumpp-Thomas C, Mok S, ... ... Winzeler EA, et al. Chemoprotective antimalarials identified through quantitative high-throughput screening of Plasmodium blood and liver stage parasites. Scientific Reports. 11: 2121. PMID 33483532 DOI: 10.1038/s41598-021-81486-z |
0.441 |
|
| 2021 |
Reader J, van der Watt ME, Taylor D, Le Manach C, Mittal N, Ottilie S, Theron A, Moyo P, Erlank E, Nardini L, Venter N, Lauterbach S, Bezuidenhout B, Horatscheck A, van Heerden A, ... ... Winzeler EA, et al. Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box. Nature Communications. 12: 269. PMID 33431834 DOI: 10.1038/s41467-020-20629-8 |
0.814 |
|
| 2020 |
Mackwitz MKW, Hesping E, Eribez K, Schöler A, Antonova-Koch Y, Held J, Winzeler EA, Andrews KT, Hansen FK. Investigation of the in vitro and in vivo efficacy of peptoid-based HDAC inhibitors with dual-stage antiplasmodial activity. European Journal of Medicinal Chemistry. 211: 113065. PMID 33360801 DOI: 10.1016/j.ejmech.2020.113065 |
0.401 |
|
| 2020 |
Fisher GM, Cobbold SA, Jezewski A, Carpenter EF, Arnold M, Cowell AN, Tjhin ET, Saliba KJ, Skinner-Adams TS, Lee MCS, Odom John A, Winzeler EA, McConville MJ, Poulsen SA, Andrews KT. The Key Glycolytic Enzyme Phosphofructokinase Is Involved in Resistance to Antiplasmodial Glycosides. Mbio. 11. PMID 33293381 DOI: 10.1128/mBio.02842-20 |
0.797 |
|
| 2020 |
Morahan BJ, Abrie C, Al-Hasani K, Batty MB, Corey V, Cowell AN, Niemand J, Winzeler EA, Birkholtz LM, Doerig C, Garcia-Bustos JF. Human Aurora kinase inhibitor Hesperadin reveals epistatic interaction between Plasmodium falciparum PfArk1 and PfNek1 kinases. Communications Biology. 3: 701. PMID 33219324 DOI: 10.1038/s42003-020-01424-z |
0.814 |
|
| 2020 |
Luth MR, Winzeler EA. SnapShot: Antimalarial Drugs. Cell. 183: 554-554.e1. PMID 33064992 DOI: 10.1016/j.cell.2020.09.006 |
0.796 |
|
| 2020 |
Eagon S, Hammill JT, Sigal MS, Ahn KJ, Tryhorn JE, Koch G, Belanger B, Chaplan CA, Loop L, Kashtanova AS, Yniguez K, Lazaro H, Wilkinson SP, Rice A, Falade M, ... ... Winzeler EA, et al. Synthesis and structure-activity relationship of dual-stage antimalarial pyrazolo[3,4-b]pyridines. Journal of Medicinal Chemistry. PMID 32945666 DOI: 10.1021/Acs.Jmedchem.0C01152 |
0.47 |
|
| 2020 |
Rocamora F, Winzeler EA. Genomic Approaches to Drug Resistance in Malaria. Annual Review of Microbiology. 74: 761-786. PMID 32905749 DOI: 10.1146/Annurev-Micro-012220-064343 |
0.499 |
|
| 2020 |
Carolino K, Winzeler EA. The antimalarial resistome - finding new drug targets and their modes of action. Current Opinion in Microbiology. 57: 49-55. PMID 32682267 DOI: 10.1016/J.Mib.2020.06.004 |
0.482 |
|
| 2020 |
Vanaerschot M, Murithi JM, Pasaje CFA, Ghidelli-Disse S, Dwomoh L, Bird M, Spottiswoode N, Mittal N, Arendse LB, Owen ES, Wicht KJ, Siciliano G, Bösche M, Yeo T, Kumar TRS, ... ... Winzeler EA, et al. Inhibition of Resistance-Refractory P. falciparum Kinase PKG Delivers Prophylactic, Blood Stage, and Transmission-Blocking Antiplasmodial Activity. Cell Chemical Biology. PMID 32359426 DOI: 10.1016/J.Chembiol.2020.04.001 |
0.505 |
|
| 2020 |
LaMonte GM, Rocamora F, Marapana DS, Gnädig NF, Ottilie S, Luth MR, Worgall TS, Goldgof GM, Mohunlal R, Santha Kumar TR, Thompson JK, Vigil E, Yang J, Hutson D, Johnson T, ... ... Winzeler EA, et al. Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway. Nature Communications. 11: 1780. PMID 32286267 DOI: 10.1038/S41467-020-15440-4 |
0.818 |
|
| 2020 |
Abraham M, Gagaring K, Marino ML, Vanaerschot M, Plouffe D, Calla J, Godinez Macias K, Du A, Wree M, Antonova-Koch Y, Eribez K, Luth MR, Ottilie S, Fidock DA, McNamara C, ... Winzeler EA, et al. Probing the Open Global Health Chemical Diversity Library for multistage-active starting points for next-generation antimalarials. Acs Infectious Diseases. PMID 32078764 DOI: 10.1021/Acsinfecdis.9B00482 |
0.812 |
|
| 2020 |
Singh S, El-Sakkary N, Skinner DE, Sharma PP, Ottilie S, Antonova-Koch Y, Kumar P, Winzeler E, Poonam, R Caffrey C, Rathi B. Synthesis and Bioactivity of Phthalimide Analogs as Potential Drugs to Treat Schistosomiasis, a Neglected Disease of Poverty. Pharmaceuticals (Basel, Switzerland). 13. PMID 32028743 DOI: 10.3390/Ph13020025 |
0.425 |
|
| 2019 |
Wong HN, Padín-Irizarry V, van der Watt ME, Reader J, Liebenberg W, Wiesner L, Smith P, Eribez K, Winzeler EA, Kyle DE, Birkholtz LM, Coertzen D, Haynes RK. Optimal 10-Aminoartemisinins With Potent Transmission-Blocking Capabilities for New Artemisinin Combination Therapies-Activities Against Blood Stage Including KI3 C580Y Mutants and Liver Stage Parasites. Frontiers in Chemistry. 7: 901. PMID 31998692 DOI: 10.3389/Fchem.2019.00901 |
0.449 |
|
| 2019 |
Skinner-Adams TS, Fisher GM, Riches AG, Hutt OE, Jarvis KE, Wilson T, von Itzstein M, Chopra P, Antonova-Koch Y, Meister S, Winzeler EA, Clarke M, Fidock DA, Burrows JN, Ryan JH, et al. Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone. Communications Biology. 2: 166. PMID 31925039 DOI: 10.1038/s42003-019-0397-3 |
0.332 |
|
| 2019 |
Murithi JM, Owen ES, Istvan ES, Lee MCS, Ottilie S, Chibale K, Goldberg DE, Winzeler EA, Llinás M, Fidock DA, Vanaerschot M. Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery. Cell Chemical Biology. PMID 31813848 DOI: 10.1016/J.Chembiol.2019.11.009 |
0.475 |
|
| 2019 |
Rosenberg A, Luth MR, Winzeler EA, Behnke M, Sibley LD. Evolution of resistance in vitro reveals mechanisms of artemisinin activity in . Proceedings of the National Academy of Sciences of the United States of America. PMID 31806760 DOI: 10.1073/Pnas.1914732116 |
0.814 |
|
| 2019 |
Mandt REK, Lafuente-Monasterio MJ, Sakata-Kato T, Luth MR, Segura D, Pablos-Tanarro A, Viera S, Magan N, Ottilie S, Winzeler EA, Lukens AK, Gamo FJ, Wirth DF. In vitro selection predicts malaria parasite resistance to dihydroorotate dehydrogenase inhibitors in a mouse infection model. Science Translational Medicine. 11. PMID 31801884 DOI: 10.1126/Scitranslmed.Aav1636 |
0.805 |
|
| 2019 |
Cowell AN, Winzeler EA. Advances in omics-based methods to identify novel targets for malaria and other parasitic protozoan infections. Genome Medicine. 11: 63. PMID 31640748 DOI: 10.1186/S13073-019-0673-3 |
0.847 |
|
| 2019 |
Clements RL, Streva V, Dumoulin P, Huang W, Owens E, Raj DK, Burleigh B, Llinás M, Winzeler EA, Zhang Q, Dvorin JD. A novel antiparasitic compound kills ring-stage Plasmodium falciparum and retains activity against artemisinin-resistant parasites. The Journal of Infectious Diseases. PMID 31616928 DOI: 10.1093/Infdis/Jiz534 |
0.553 |
|
| 2019 |
Alam MM, Sanchez-Azqueta A, Janha O, Flannery EL, Mahindra A, Mapesa K, Char AB, Sriranganadane D, Brancucci NMB, Antonova-Koch Y, Crouch K, Simwela NV, Millar SB, Akinwale J, Mitcheson D, ... ... Winzeler EA, et al. Validation of the protein kinase CLK3 as a multistage cross-species malarial drug target. Science (New York, N.Y.). 365. PMID 31467193 DOI: 10.1126/Science.Aau1682 |
0.494 |
|
| 2019 |
Winzeler EA. A roadmap for malaria research. Science (New York, N.Y.). 365: 753-754. PMID 31439782 DOI: 10.1126/Science.Aay5963 |
0.313 |
|
| 2019 |
Norcross NR, Wilson C, Baragaña B, Hallyburton I, Osuna-Cabello M, Norval S, Riley J, Fletcher D, Sinden R, Delves M, Ruecker A, Duffy S, Meister S, Antonova-Koch Y, Crespo B, ... ... Winzeler EA, et al. Substituted aminoacetamides as novel leads for malaria. Chemmedchem. PMID 31188540 DOI: 10.1002/Cmdc.201900329 |
0.52 |
|
| 2019 |
Stokes BH, Yoo E, Murithi JM, Luth MR, Afanasyev P, da Fonseca PCA, Winzeler EA, Ng CL, Bogyo M, Fidock DA. Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. Plos Pathogens. 15: e1007722. PMID 31170268 DOI: 10.1371/Journal.Ppat.1007722 |
0.804 |
|
| 2019 |
Cowell AN, Winzeler EA. The genomic architecture of antimalarial drug resistance. Briefings in Functional Genomics. PMID 31119263 DOI: 10.1093/Bfgp/Elz008 |
0.837 |
|
| 2019 |
Winzeler EA, Ottilie S. The proteasome as a target: How not tidying up can have toxic consequences for parasitic protozoa. Proceedings of the National Academy of Sciences of the United States of America. 116: 10198-10200. PMID 31085658 DOI: 10.1073/Pnas.1904694116 |
0.466 |
|
| 2019 |
Skinner-Adams TS, Fisher GM, Riches AG, Hutt OE, Jarvis KE, Wilson T, von Itzstein M, Chopra P, Antonova-Koch Y, Meister S, Winzeler EA, Clarke M, Fidock DA, Burrows JN, Ryan JH, et al. Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone. Communications Biology. 2: 166. PMID 31069275 DOI: 10.1038/s42003-019-0397-3 |
0.326 |
|
| 2019 |
Baragaña B, Forte B, Choi R, Nakazawa Hewitt S, Bueren-Calabuig JA, Pisco JP, Peet C, Dranow DM, Robinson DA, Jansen C, Norcross NR, Vinayak S, Anderson M, Brooks CF, Cooper CA, ... ... Winzeler EA, et al. Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis. Proceedings of the National Academy of Sciences of the United States of America. PMID 30894487 DOI: 10.1073/Pnas.1814685116 |
0.745 |
|
| 2019 |
Istvan E, Das S, Bhatnagar S, Beck JR, Owen E, Llinas M, Ganesan SM, Niles JC, Winzeler E, Vaidya AB, Goldberg DE. Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis. Elife. 8. PMID 30888318 DOI: 10.7554/Elife.40529 |
0.457 |
|
| 2019 |
LaMonte GM, Orjuela-Sanchez P, Calla J, Wang LT, Li S, Swann J, Cowell AN, Zou BY, Abdel-Haleem Mohamed AM, Villa Galarce ZH, Moreno M, Tong Rios C, Vinetz JM, Lewis N, Winzeler EA. Dual RNA-seq identifies human mucosal immunity protein Mucin-13 as a hallmark of Plasmodium exoerythrocytic infection. Nature Communications. 10: 488. PMID 30700707 DOI: 10.1038/S41467-019-08349-0 |
0.805 |
|
| 2019 |
Mackwitz MKW, Hesping E, Antonova-Koch Y, Diedrich D, Gebru T, Skinner-Adams T, Clarke M, Schöler A, Limbach L, Kurz T, Winzeler EA, Held J, Andrews K, Hansen FK. Structure-Activity and Structure-Toxicity Relationships of Novel Peptoid-Based Histone Deacetylase Inhibitors with Dual-Stage Antiplasmodial Activity. Chemmedchem. PMID 30664827 DOI: 10.1002/Cmdc.201800808 |
0.493 |
|
| 2019 |
Fagundez C, Sellanes D, Peña S, Scarone L, Aguiar ACC, de Souza JO, Guido RVC, Stewart L, Yardley V, Ottilie S, Winzeler EA, Gamo FJ, Sanz LM, Serra GL. Synthesis, Profiling, and in Vivo Evaluation of Cyclopeptides Containing -Methyl Amino Acids as Antiplasmodial Agents. Acs Medicinal Chemistry Letters. 10: 137-141. PMID 30655961 DOI: 10.1021/Acsmedchemlett.8B00543 |
0.311 |
|
| 2019 |
Leven M, Held J, Duffy S, Alves Avelar LA, Meister S, Delves M, Plouffe D, Kuna K, Tschan S, Avery VM, Winzeler EA, Mordmüller B, Kurz T. 8-Aminoquinolines with an Aminoxyalkyl Side Chain Exert in vitro Dual-Stage Antiplasmodial Activity. Chemmedchem. PMID 30605243 DOI: 10.1002/Cmdc.201800691 |
0.38 |
|
| 2019 |
Winzeler EA. An improbable journey: Creativity helped me make the transition from art to curing malaria. The Journal of Biological Chemistry. 294: 405-409. PMID 30401750 DOI: 10.1074/Jbc.Aw118.005229 |
0.349 |
|
| 2019 |
Istvan ES, Das S, Bhatnagar S, Beck JR, Owen E, Llinas M, Ganesan SM, Niles JC, Winzeler E, Vaidya AB, Goldberg DE. Author response: Plasmodium Niemann-Pick type C1-related protein is a druggable target required for parasite membrane homeostasis Elife. DOI: 10.7554/Elife.40529.032 |
0.318 |
|
| 2018 |
Antonova-Koch Y, Meister S, Abraham M, Luth MR, Ottilie S, Lukens AK, Sakata-Kato T, Vanaerschot M, Owen E, Jado Rodriguez JC, Maher SP, Calla J, Plouffe D, Zhong Y, Chen K, ... ... Winzeler EA, et al. Open-source discovery of chemical leads for next-generation chemoprotective antimalarials. Science (New York, N.Y.). 362. PMID 30523084 DOI: 10.1126/Science.Aat9446 |
0.821 |
|
| 2018 |
Cowell A, Winzeler E. Exploration of the Resistome and Druggable Genome Reveals New Mechanisms of Drug Resistance and Antimalarial Targets. Microbiology Insights. 11: 1178636118808529. PMID 30505148 DOI: 10.1177/1178636118808529 |
0.825 |
|
| 2018 |
Xie SC, Gillett DL, Spillman NJ, Tsu C, Luth MR, Ottilie S, Duffy S, Gould A, Hales P, Seager BA, Charron CL, Bruzzese F, Yang X, Zhao X, Huang SC, ... ... Winzeler EA, et al. Target Validation and Identification of Novel Boronate Inhibitors of the Plasmodium falciparum Proteasome. Journal of Medicinal Chemistry. PMID 30373366 DOI: 10.1021/Acs.Jmedchem.8B01161 |
0.804 |
|
| 2018 |
Diedrich D, Stenzel K, Hesping E, Antonova-Koch Y, Gebru T, Duffy S, Fisher G, Schöler A, Meister S, Kurz T, Avery VM, Winzeler EA, Held J, Andrews KT, Hansen FK. One-pot, multi-component synthesis and structure-activity relationships of peptoid-based histone deacetylase (HDAC) inhibitors targeting malaria parasites. European Journal of Medicinal Chemistry. 158: 801-813. PMID 30245402 DOI: 10.1016/J.Ejmech.2018.09.018 |
0.514 |
|
| 2018 |
Delves MJ, Miguel-Blanco C, Matthews H, Molina I, Ruecker A, Yahiya S, Straschil U, Abraham M, León ML, Fischer OJ, Rueda-Zubiaurre A, Brandt JR, Cortés Á, Barnard A, Fuchter MJ, ... ... Winzeler EA, et al. A high throughput screen for next-generation leads targeting malaria parasite transmission. Nature Communications. 9: 3805. PMID 30228275 DOI: 10.1038/S41467-018-05777-2 |
0.83 |
|
| 2018 |
Cowell AN, Valdivia HO, Bishop DK, Winzeler EA. Exploration of Plasmodium vivax transmission dynamics and recurrent infections in the Peruvian Amazon using whole genome sequencing. Genome Medicine. 10: 52. PMID 29973248 DOI: 10.1186/S13073-018-0563-0 |
0.79 |
|
| 2018 |
Llanos-Cuentas A, Casapia M, Chuquiyauri R, Hinojosa JC, Kerr N, Rosario M, Toovey S, Arch RH, Phillips MA, Rozenberg FD, Bath J, Ng CL, Cowell AN, Winzeler EA, Fidock DA, et al. Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study. The Lancet. Infectious Diseases. PMID 29909069 DOI: 10.1016/S1473-3099(18)30309-8 |
0.801 |
|
| 2018 |
Ma S, Cahalan S, LaMonte G, Grubaugh ND, Zeng W, Murthy SE, Paytas E, Gamini R, Lukacs V, Whitwam T, Loud M, Lohia R, Berry L, Khan SM, Janse CJ, ... ... Winzeler EA, et al. Common PIEZO1 Allele in African Populations Causes RBC Dehydration and Attenuates Plasmodium Infection. Cell. 173: 443-455.e12. PMID 29576450 DOI: 10.1016/J.Cell.2018.02.047 |
0.398 |
|
| 2018 |
Winzeler EA. A Sleeping Area of Malaria Research Awakes. Cell Host & Microbe. 23: 292-295. PMID 29544094 DOI: 10.1016/J.Chom.2018.02.008 |
0.398 |
|
| 2018 |
Orjuela-Sanchez P, Villa ZH, Moreno M, Tong-Rios C, Meister S, LaMonte GM, Campo B, Vinetz JM, Winzeler EA. Developing Plasmodium vivax Resources for Liver Stage Study in the Peruvian Amazon Region. Acs Infectious Diseases. PMID 29542317 DOI: 10.1021/Acsinfecdis.7B00198 |
0.459 |
|
| 2018 |
Moreno M, Tong-Rios C, Orjuela-Sanchez P, Carrasco-Escobar G, Campo B, Gamboa D, Winzeler EA, Vinetz JM. Continuous Supply of Plasmodium vivax Sporozoites from Colonized Anopheles darlingi in the Peruvian Amazon. Acs Infectious Diseases. PMID 29465219 DOI: 10.1021/Acsinfecdis.7B00195 |
0.39 |
|
| 2018 |
Luth MR, Gupta P, Ottilie S, Winzeler EA. Using in Vitro Evolution and Whole Genome Analysis (IVIEWGA) to discover next generation targets for antimalarial drug discovery. Acs Infectious Diseases. PMID 29451780 DOI: 10.1021/Acsinfecdis.7B00276 |
0.787 |
|
| 2018 |
Cowell AN, Istvan ES, Lukens AK, Gomez-Lorenzo MG, Vanaerschot M, Sakata-Kato T, Flannery EL, Magistrado P, Owen E, Abraham M, LaMonte G, Painter HJ, Williams RM, Franco V, Linares M, ... ... Winzeler EA, et al. Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics. Science (New York, N.Y.). 359: 191-199. PMID 29326268 DOI: 10.1126/Science.Aan4472 |
0.84 |
|
| 2018 |
Beteck RM, Seldon R, Coertzen D, van der Watt ME, Reader J, Mackenzie JS, Lamprecht DA, Abraham M, Eribez K, Müller J, Rui F, Zhu G, de Grano RV, Williams ID, Smit FJ, ... ... Winzeler EA, et al. Accessible and distinct decoquinate derivatives active against Mycobacterium tuberculosis and apicomplexan parasites Communications Chemistry. 1. DOI: 10.1038/s42004-018-0062-7 |
0.779 |
|
| 2017 |
Rabinovich RN, Drakeley C, Djimde AA, Hall BF, Hay SI, Hemingway J, Kaslow DC, Noor A, Okumu F, Steketee R, Tanner M, Wells TNC, Whittaker MA, Winzeler EA, Wirth DF, et al. malERA: An updated research agenda for malaria elimination and eradication. Plos Medicine. 14: e1002456. PMID 29190300 DOI: 10.1371/Journal.Pmed.1002456 |
0.372 |
|
| 2017 |
Stenzel K, Chua MJ, Duffy S, Antonova-Koch Y, Meister S, Hamacher A, Kassack MU, Winzeler EA, Avery VM, Kurz T, Andrews KT, Hansen FK. Design and synthesis of terephthalic acid-based histone deacetylase inhibitors with dual stage anti-Plasmodium activity. Chemmedchem. PMID 28812327 DOI: 10.1002/Cmdc.201700360 |
0.468 |
|
| 2017 |
Vanaerschot M, Lucantoni L, Li T, Combrinck JM, Ruecker A, Kumar TRS, Rubiano K, Ferreira PE, Siciliano G, Gulati S, Henrich PP, Ng CL, Murithi JM, Corey VC, Duffy S, ... ... Winzeler EA, et al. Hexahydroquinolines are antimalarial candidates with potent blood-stage and transmission-blocking activity. Nature Microbiology. PMID 28808258 DOI: 10.1038/S41564-017-0007-4 |
0.838 |
|
| 2017 |
LaMonte GM, Almaliti J, Bibo-Verdugo B, Keller L, Zou BY, Yang J, Antonova-Koch Y, Orjuela-Sanchez P, Boyle CA, Vigil E, Wang L, Goldgof GM, Gerwick L, O'Donoghue AJ, Winzeler EA, et al. Development of a potent inhibitor of the Plasmodium proteasome with reduced mammalian toxicity. Journal of Medicinal Chemistry. PMID 28696697 DOI: 10.1021/Acs.Jmedchem.7B00671 |
0.487 |
|
| 2017 |
Leven M, Knaab TC, Held J, Duffy S, Meister S, Fischli C, Meitzner D, Lehmann U, Lungerich B, Kuna K, Stahlke P, Delves MJ, Buchholz M, Winzeler EA, Avery VM, et al. 3-Hydroxy-N'-arylidenepropanehydrazonamides with halo-substituted phenanthrene scaffolds cure P. berghei-infected mice when administered perorally. Journal of Medicinal Chemistry. PMID 28653845 DOI: 10.1021/Acs.Jmedchem.7B00140 |
0.404 |
|
| 2017 |
Winzeler EA. Glycophorin alleles link to malaria protection. Science (New York, N.Y.). 356: 1122-1123. PMID 28619899 DOI: 10.1126/Science.Aan4184 |
0.413 |
|
| 2017 |
Dhingra SK, Redhi D, Combrinck JM, Yeo T, Okombo J, Henrich PP, Cowell AN, Gupta P, Stegman ML, Hoke JM, Cooper RA, Winzeler E, Mok S, Egan TJ, Fidock DA. A Variant PfCRT Isoform Can Contribute to Plasmodium falciparum Resistance to the First-Line Partner Drug Piperaquine. Mbio. 8. PMID 28487425 DOI: 10.1128/Mbio.00303-17 |
0.828 |
|
| 2017 |
Winzeler EA. Longitudinal study of Plasmodium pathogens identifies new loci associated with artemisinin resistance. Genome Biology. 18: 79. PMID 28454594 DOI: 10.1186/S13059-017-1219-X |
0.484 |
|
| 2017 |
Cowell AN, Loy DE, Sundararaman SA, Valdivia H, Fisch K, Lescano AG, Baldeviano GC, Durand S, Gerbasi V, Sutherland CJ, Nolder D, Vinetz JM, Hahn BH, Winzeler EA. Selective Whole-Genome Amplification Is a Robust Method That Enables Scalable Whole-Genome Sequencing of Plasmodium vivax from Unprocessed Clinical Samples. Mbio. 8. PMID 28174312 DOI: 10.1128/Mbio.02257-16 |
0.799 |
|
| 2017 |
Istvan ES, Mallari JP, Corey VC, Dharia NV, Marshall GR, Winzeler EA, Goldberg DE. Esterase mutation is a mechanism of resistance to antimalarial compounds. Nature Communications. 8: 14240. PMID 28106035 DOI: 10.1038/Ncomms14240 |
0.84 |
|
| 2016 |
Ottilie S, Goldgof GM, Calvet CM, Jennings GK, LaMonte G, Schenken J, Vigil E, Kumar P, McCall LI, Lopes ES, Gunawan F, Yang J, Suzuki Y, Siqueira-Neto JL, McKerrow JH, ... ... Winzeler EA, et al. Rapid Chagas disease drug target discovery using directed evolution in drug-sensitive yeast. Acs Chemical Biology. PMID 27977118 DOI: 10.1021/Acschembio.6B01037 |
0.465 |
|
| 2016 |
Magistrado PA, Corey VC, Lukens AK, LaMonte G, Sasaki E, Meister S, Wree M, Winzeler E, Wirth DF. Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes. Acs Infectious Diseases. 2: 816-826. PMID 27933786 DOI: 10.1021/Acsinfecdis.6B00025 |
0.821 |
|
| 2016 |
Williamson AE, Ylioja PM, Robertson MN, Antonova-Koch Y, Avery V, Baell JB, Batchu H, Batra S, Burrows JN, Bhattacharyya S, Calderon F, Charman SA, Clark J, Crespo B, Dean M, ... ... Winzeler EA, et al. Open Source Drug Discovery: Highly Potent Antimalarial Compounds Derived from the Tres Cantos Arylpyrroles. Acs Central Science. 2: 687-701. PMID 27800551 DOI: 10.1021/Acscentsci.6B00086 |
0.734 |
|
| 2016 |
Le Manach C, Nchinda AT, Paquet T, Gonzalez Cabrera D, Younis Adam Y, Han Z, Bashyam S, Zabiulla M, Taylor D, Lawrence N, White KL, Charman SA, Waterson D, Witty MJ, Wittlin S, ... ... Winzeler EA, et al. Identification of a potential anti-malarial drug candidate from a series of 2-aminopyrazines by optimization of aqueous solubility and potency across the parasite life-cycle. Journal of Medicinal Chemistry. PMID 27748596 DOI: 10.1021/Acs.Jmedchem.6B01265 |
0.477 |
|
| 2016 |
Lim MY, LaMonte G, Lee MC, Reimer C, Tan BH, Corey V, Tjahjadi BF, Chua A, Nachon M, Wintjens R, Gedeck P, Malleret B, Renia L, Bonamy GM, Ho PC, ... ... Winzeler EA, et al. UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes. Nature Microbiology. 1: 16166. PMID 27642791 DOI: 10.1038/Nmicrobiol.2016.166 |
0.816 |
|
| 2016 |
Baragaña B, Norcross NR, Wilson C, Porzelle A, Hallyburton I, Grimaldi R, Osuna-Cabello M, Norval S, Riley J, Stojanovski L, Simeons FR, Wyatt PG, Delves MJ, Meister S, Duffy S, ... ... Winzeler EA, et al. Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. Journal of Medicinal Chemistry. PMID 27631715 DOI: 10.1021/Acs.Jmedchem.6B00723 |
0.406 |
|
| 2016 |
Kato N, Comer E, Sakata-Kato T, Sharma A, Sharma M, Maetani M, Bastien J, Brancucci NM, Bittker JA, Corey V, Clarke D, Derbyshire ER, Dornan G, Duffy S, Eckley S, ... ... Winzeler EA, et al. Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. Nature. PMID 27602946 DOI: 10.1038/Nature19804 |
0.8 |
|
| 2016 |
Van Voorhis WC, Adams JH, Adelfio R, Ahyong V, Akabas MH, Alano P, Alday A, Alemán Resto Y, Alsibaee A, Alzualde A, Andrews KT, Avery SV, Avery VM, Ayong L, Baker M, ... ... Winzeler EA, et al. Open Source Drug Discovery with the Malaria Box Compound Collection for Neglected Diseases and Beyond. Plos Pathogens. 12: e1005763. PMID 27467575 DOI: 10.1371/Journal.Ppat.1005763 |
0.501 |
|
| 2016 |
LaMonte G, Lim MY, Wree M, Reimer C, Nachon M, Corey V, Gedeck P, Plouffe D, Du A, Figueroa N, Yeung B, Bifani P, Winzeler EA. Mutations in the Plasmodium falciparum Cyclic Amine Resistance Locus (PfCARL) Confer Multidrug Resistance. Mbio. 7. PMID 27381290 DOI: 10.1128/Mbio.00696-16 |
0.822 |
|
| 2016 |
Norcross NR, Baragaña B, Wilson C, Hallyburton I, Osuna-Cabello M, Norval S, Riley J, Stojanovski L, Simeons FR, Porzelle A, Grimaldi R, Wittlin S, Duffy S, Avery VM, Meister S, ... ... Winzeler EA, et al. Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials. Journal of Medicinal Chemistry. PMID 27314305 DOI: 10.1021/Acs.Jmedchem.6B00028 |
0.395 |
|
| 2016 |
Corey VC, Lukens AK, Istvan ES, Lee MC, Franco V, Magistrado P, Coburn-Flynn O, Sakata-Kato T, Fuchs O, Gnädig NF, Goldgof G, Linares M, Gomez-Lorenzo MG, De Cózar C, Lafuente-Monasterio MJ, ... ... Winzeler EA, et al. A broad analysis of resistance development in the malaria parasite. Nature Communications. 7: 11901. PMID 27301419 DOI: 10.1038/Ncomms11901 |
0.804 |
|
| 2016 |
Goldgof GM, Durrant JD, Ottilie S, Vigil E, Allen KE, Gunawan F, Kostylev M, Henderson KA, Yang J, Schenken J, LaMonte GM, Manary MJ, Murao A, Nachon M, Stanhope R, ... ... Winzeler EA, et al. Comparative chemical genomics reveal that the spiroindolone antimalarial KAE609 (Cipargamin) is a P-type ATPase inhibitor. Scientific Reports. 6: 27806. PMID 27291296 DOI: 10.1038/Srep27806 |
0.72 |
|
| 2016 |
Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, ... ... Winzeler EA, et al. Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. PMID 27281209 DOI: 10.1038/Nature18280 |
0.366 |
|
| 2016 |
Swann J, Corey V, Scherer CA, Kato N, Comer E, Maetani M, Antonova-Koch Y, Reimer C, Gagaring K, Ibanez M, Plouffe D, Zeeman AM, Kocken CH, McNamara CW, Schreiber SL, ... ... Winzeler EA, et al. High-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent Malaria. Acs Infectious Diseases. 2: 281-293. PMID 27275010 DOI: 10.1021/Acsinfecdis.5B00143 |
0.839 |
|
| 2016 |
Hovlid ML, Winzeler EA. Phenotypic Screens in Antimalarial Drug Discovery. Trends in Parasitology. 32: 697-707. PMID 27247245 DOI: 10.1016/J.Pt.2016.04.014 |
0.407 |
|
| 2016 |
Lu HH, Pronin SV, Antonova-Koch Y, Meister S, Winzeler EA, Shenvi RA. Synthesis of (+)-7,20-Diisocyanoadociane and Liver-Stage Antiplasmodial Activity of the Isocyanoterpene Class. Journal of the American Chemical Society. PMID 27244042 DOI: 10.1021/Jacs.6B03899 |
0.37 |
|
| 2016 |
Ng CL, Siciliano G, Lee MC, de Almeida MJ, Corey VC, Bopp SE, Bertuccini L, Wittlin S, Kasdin RG, Le Bihan A, Clozel M, Winzeler EA, Alano P, Fidock DA. CRISPR-Cas9-modified pfmdr1 protects Plasmodium falciparum asexual blood stages and gametocytes against a class of piperazine-containing compounds but potentiates artemisinin-based combination therapy partner drugs. Molecular Microbiology. PMID 27073104 DOI: 10.1111/Mmi.13397 |
0.855 |
|
| 2016 |
Lehmann JS, Corey VC, Ricaldi JN, Vinetz JM, Winzeler EA, Matthias MA. Whole Genome Shotgun Sequencing Shows Selection on Leptospira Regulatory Proteins During in vitro Culture Attenuation. The American Journal of Tropical Medicine and Hygiene. 94: 302-13. PMID 26711524 DOI: 10.4269/Ajtmh.15-0401 |
0.759 |
|
| 2016 |
Lehmann JS, Corey VC, Ricaldi JN, Vinetz JM, Winzeler EA, Matthias MA. Whole genome shotgun sequencing shows selection on leptospira regulatory proteins during in vitro culture attenuation American Journal of Tropical Medicine and Hygiene. 94: 302-313. DOI: 10.4269/ajtmh.15-0401 |
0.732 |
|
| 2015 |
Plouffe DM, Wree M, Du AY, Meister S, Li F, Patra K, Lubar A, Okitsu SL, Flannery EL, Kato N, Tanaseichuk O, Comer E, Zhou B, Kuhen K, Zhou Y, ... ... Winzeler EA, et al. High-Throughput Assay and Discovery of Small Molecules that Interrupt Malaria Transmission. Cell Host & Microbe. PMID 26749441 DOI: 10.1016/J.Chom.2015.12.001 |
0.478 |
|
| 2015 |
Flannery EL, Wang T, Akbari A, Corey VC, Gunawan F, Bright AT, Abraham M, Sanchez JF, Santolalla ML, Baldeviano GC, Edgel KA, Rosales LA, Lescano AG, Bafna V, Vinetz JM, ... Winzeler EA, et al. Next-Generation Sequencing of Plasmodium vivax Patient Samples Shows Evidence of Direct Evolution in Drug-Resistance Genes. Acs Infectious Diseases. 1: 367-379. PMID 26719854 DOI: 10.1021/Acsinfecdis.5B00049 |
0.852 |
|
| 2015 |
Le Manach C, Paquet T, Brunschwig C, Njoroge M, Han Z, Gonzàlez Cabrera D, Bashyam S, Dhinakaran R, Taylor D, Reader J, Botha M, Churchyard A, Lauterbach S, Coetzer TL, Birkholtz LM, ... ... Winzeler EA, et al. A Novel Pyrazolopyridine with in Vivo Activity in Plasmodium berghei- and Plasmodium falciparum-Infected Mouse Models from Structure-Activity Relationship Studies around the Core of Recently Identified Antimalarial Imidazopyridazines. Journal of Medicinal Chemistry. 58: 8713-22. PMID 26502160 DOI: 10.1021/Acs.Jmedchem.5B01605 |
0.447 |
|
| 2015 |
Swann J, Jamshidi N, Lewis NE, Winzeler EA. Systems analysis of host-parasite interactions. Wiley Interdisciplinary Reviews. Systems Biology and Medicine. PMID 26306749 DOI: 10.1002/Wsbm.1311 |
0.459 |
|
| 2015 |
Baragaña B, Hallyburton I, Lee MC, Norcross NR, Grimaldi R, Otto TD, Proto WR, Blagborough AM, Meister S, Wirjanata G, Ruecker A, Upton LM, Abraham TS, Almeida MJ, Pradhan A, ... ... Winzeler EA, et al. A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 522: 315-20. PMID 26085270 DOI: 10.1038/Nature14451 |
0.524 |
|
| 2015 |
Suzuki Y, Assad-Garcia N, Kostylev M, Noskov VN, Wise KS, Karas BJ, Stam J, Montague MG, Hanly TJ, Enriquez NJ, Ramon A, Goldgof GM, Richter RA, Vashee S, Chuang RY, ... Winzeler EA, et al. Bacterial genome reduction using the progressive clustering of deletions via yeast sexual cycling. Genome Research. 25: 435-44. PMID 25654978 DOI: 10.1101/Gr.182477.114 |
0.343 |
|
| 2015 |
Flannery EL, McNamara CW, Kim SW, Kato TS, Li F, Teng CH, Gagaring K, Manary MJ, Barboa R, Meister S, Kuhen K, Vinetz JM, Chatterjee AK, Winzeler EA. Mutations in the P-type cation-transporter ATPase 4, PfATP4, mediate resistance to both aminopyrazole and spiroindolone antimalarials. Acs Chemical Biology. 10: 413-20. PMID 25322084 DOI: 10.1021/Cb500616X |
0.764 |
|
| 2014 |
Winzeler EA, Manary MJ. Drug resistance genomics of the antimalarial drug artemisinin. Genome Biology. 15: 544. PMID 25470531 DOI: 10.1186/S13059-014-0544-6 |
0.535 |
|
| 2014 |
Goel S, Muthusamy A, Miao J, Cui L, Salanti A, Winzeler EA, Gowda DC. Targeted disruption of a ring-infected erythrocyte surface antigen (RESA)-like export protein gene in Plasmodium falciparum confers stable chondroitin 4-sulfate cytoadherence capacity. The Journal of Biological Chemistry. 289: 34408-21. PMID 25342752 DOI: 10.1074/Jbc.M114.615393 |
0.396 |
|
| 2014 |
Zou B, Nagle A, Chatterjee AK, Leong SY, Tan LJ, Sim WL, Mishra P, Guntapalli P, Tully DC, Lakshminarayana SB, Lim CS, Tan YC, Abas SN, Bodenreider C, Kuhen KL, ... ... Winzeler EA, et al. Lead optimization of imidazopyrazines: a new class of antimalarial with activity on Plasmodium liver stages. Acs Medicinal Chemistry Letters. 5: 947-50. PMID 25147620 DOI: 10.1021/Ml500244M |
0.709 |
|
| 2014 |
Kuhen KL, Chatterjee AK, Rottmann M, Gagaring K, Borboa R, Buenviaje J, Chen Z, Francek C, Wu T, Nagle A, Barnes SW, Plouffe D, Lee MC, Fidock DA, Graumans W, ... ... Winzeler EA, et al. KAF156 is an antimalarial clinical candidate with potential for use in prophylaxis, treatment, and prevention of disease transmission. Antimicrobial Agents and Chemotherapy. 58: 5060-7. PMID 24913172 DOI: 10.1128/Aac.02727-13 |
0.492 |
|
| 2014 |
Hansen FK, Sumanadasa SD, Stenzel K, Duffy S, Meister S, Marek L, Schmetter R, Kuna K, Hamacher A, Mordmüller B, Kassack MU, Winzeler EA, Avery VM, Andrews KT, Kurz T. Discovery of HDAC inhibitors with potent activity against multiple malaria parasite life cycle stages. European Journal of Medicinal Chemistry. 82: 204-13. PMID 24904967 DOI: 10.1016/J.Ejmech.2014.05.050 |
0.48 |
|
| 2014 |
Bright AT, Manary MJ, Tewhey R, Arango EM, Wang T, Schork NJ, Yanow SK, Winzeler EA. A high resolution case study of a patient with recurrent Plasmodium vivax infections shows that relapses were caused by meiotic siblings. Plos Neglected Tropical Diseases. 8: e2882. PMID 24901334 DOI: 10.1371/Journal.Pntd.0002882 |
0.484 |
|
| 2014 |
Manary MJ, Singhakul SS, Flannery EL, Bopp SE, Corey VC, Bright AT, McNamara CW, Walker JR, Winzeler EA. Identification of pathogen genomic variants through an integrated pipeline. Bmc Bioinformatics. 15: 63. PMID 24589256 DOI: 10.1186/1471-2105-15-63 |
0.782 |
|
| 2014 |
Moreno M, Tong C, Guzmán M, Chuquiyauri R, Llanos-Cuentas A, Rodriguez H, Gamboa D, Meister S, Winzeler EA, Maguina P, Conn JE, Vinetz JM. Infection of laboratory-colonized Anopheles darlingi mosquitoes by Plasmodium vivax. The American Journal of Tropical Medicine and Hygiene. 90: 612-6. PMID 24534811 DOI: 10.4269/Ajtmh.13-0708 |
0.374 |
|
| 2014 |
Zeeman AM, van Amsterdam SM, McNamara CW, Voorberg-van der Wel A, Klooster EJ, van den Berg A, Remarque EJ, Plouffe DM, van Gemert GJ, Luty A, Sauerwein R, Gagaring K, Borboa R, Chen Z, Kuhen K, ... ... Winzeler EA, et al. KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro. Antimicrobial Agents and Chemotherapy. 58: 1586-95. PMID 24366744 DOI: 10.1128/Aac.01927-13 |
0.72 |
|
| 2014 |
Flannery EL, Chatterjee AK, Winzeler EA. Erratum: Antimalarial drug discovery — approaches and progress towards new medicines Nature Reviews Microbiology. 12: 70-70. DOI: 10.1038/Nrmicro3183 |
0.417 |
|
| 2013 |
McNamara CW, Lee MC, Lim CS, Lim SH, Roland J, Simon O, Yeung BK, Chatterjee AK, McCormack SL, Manary MJ, Zeeman AM, Dechering KJ, Kumar TS, Henrich PP, Gagaring K, ... ... Winzeler EA, et al. Targeting Plasmodium PI(4)K to eliminate malaria. Nature. 504: 248-253. PMID 24284631 DOI: 10.1038/Nature12782 |
0.736 |
|
| 2013 |
Flannery EL, Chatterjee AK, Winzeler EA. Antimalarial drug discovery - approaches and progress towards new medicines. Nature Reviews. Microbiology. 11: 849-62. PMID 24217412 DOI: 10.1038/Nrmicro3138 |
0.438 |
|
| 2013 |
Bopp SE, Rodrigo E, González-Páez GE, Frazer M, Barnes SW, Valim C, Watson J, Walker JR, Schmedt C, Winzeler EA. Identification of the Plasmodium berghei resistance locus 9 linked to survival on chromosome 9. Malaria Journal. 12: 316. PMID 24025732 DOI: 10.1186/1475-2875-12-316 |
0.796 |
|
| 2013 |
Flannery EL, Fidock DA, Winzeler EA. Using genetic methods to define the targets of compounds with antimalarial activity. Journal of Medicinal Chemistry. 56: 7761-71. PMID 23927658 DOI: 10.1021/Jm400325J |
0.534 |
|
| 2013 |
McCarthy JS, Griffin PM, Sekuloski S, Bright AT, Rockett R, Looke D, Elliott S, Whiley D, Sloots T, Winzeler EA, Trenholme KR. Experimentally induced blood-stage Plasmodium vivax infection in healthy volunteers. The Journal of Infectious Diseases. 208: 1688-94. PMID 23908484 DOI: 10.1093/Infdis/Jit394 |
0.383 |
|
| 2013 |
Bright AT, Winzeler EA. Epidemiology: resistance mapping in malaria. Nature. 498: 446-7. PMID 23803843 DOI: 10.1038/498446B |
0.497 |
|
| 2013 |
Bright AT, Alenazi T, Shokoples S, Tarning J, Paganotti GM, White NJ, Houston S, Winzeler EA, Yanow SK. Genetic analysis of primaquine tolerance in a patient with relapsing vivax malaria. Emerging Infectious Diseases. 19: 802-5. PMID 23648098 DOI: 10.3201/Eid1905.121852 |
0.434 |
|
| 2013 |
Falkard B, Kumar TR, Hecht LS, Matthews KA, Henrich PP, Gulati S, Lewis RE, Manary MJ, Winzeler EA, Sinnis P, Prigge ST, Heussler V, Deschermeier C, Fidock D. A key role for lipoic acid synthesis during Plasmodium liver stage development. Cellular Microbiology. 15: 1585-604. PMID 23490300 DOI: 10.1111/Cmi.12137 |
0.404 |
|
| 2013 |
Spillman NJ, Allen RJ, McNamara CW, Yeung BK, Winzeler EA, Diagana TT, Kirk K. Na(+) regulation in the malaria parasite Plasmodium falciparum involves the cation ATPase PfATP4 and is a target of the spiroindolone antimalarials. Cell Host & Microbe. 13: 227-37. PMID 23414762 DOI: 10.1016/J.Chom.2012.12.006 |
0.717 |
|
| 2013 |
Bopp SE, Manary MJ, Bright AT, Johnston GL, Dharia NV, Luna FL, McCormack S, Plouffe D, McNamara CW, Walker JR, Fidock DA, Denchi EL, Winzeler EA. Mitotic evolution of Plasmodium falciparum shows a stable core genome but recombination in antigen families. Plos Genetics. 9: e1003293. PMID 23408914 DOI: 10.1371/Journal.Pgen.1003293 |
0.837 |
|
| 2012 |
Coleman BI, Ribacke U, Manary M, Bei AK, Winzeler EA, Wirth DF, Duraisingh MT. Nuclear repositioning precedes promoter accessibility and is linked to the switching frequency of a Plasmodium falciparum invasion gene. Cell Host & Microbe. 12: 739-50. PMID 23245319 DOI: 10.1016/J.Chom.2012.11.004 |
0.367 |
|
| 2012 |
Harbut MB, Patel BA, Yeung BK, McNamara CW, Bright AT, Ballard J, Supek F, Golde TE, Winzeler EA, Diagana TT, Greenbaum DC. Targeting the ERAD pathway via inhibition of signal peptide peptidase for antiparasitic therapeutic design. Proceedings of the National Academy of Sciences of the United States of America. 109: 21486-91. PMID 23236186 DOI: 10.1073/Pnas.1216016110 |
0.737 |
|
| 2012 |
Nicolaou KC, Lu M, Totokotsopoulos S, Heretsch P, Giguère D, Sun YP, Sarlah D, Nguyen TH, Wolf IC, Smee DF, Day CW, Bopp S, Winzeler EA. Synthesis and biological evaluation of epidithio-, epitetrathio-, and bis-(methylthio)diketopiperazines: synthetic methodology, enantioselective total synthesis of epicoccin G, 8,8'-epi-ent-rostratin B, gliotoxin, gliotoxin G, emethallicin E, and haematocin and discovery of new antiviral and antimalarial agents. Journal of the American Chemical Society. 134: 17320-32. PMID 22978674 DOI: 10.1021/Ja308429F |
0.73 |
|
| 2012 |
Bright AT, Tewhey R, Abeles S, Chuquiyauri R, Llanos-Cuentas A, Ferreira MU, Schork NJ, Vinetz JM, Winzeler EA. Whole genome sequencing analysis of Plasmodium vivax using whole genome capture. Bmc Genomics. 13: 262. PMID 22721170 DOI: 10.1186/1471-2164-13-262 |
0.414 |
|
| 2012 |
Hoepfner D, McNamara CW, Lim CS, Studer C, Riedl R, Aust T, McCormack SL, Plouffe DM, Meister S, Schuierer S, Plikat U, Hartmann N, Staedtler F, Cotesta S, Schmitt EK, ... ... Winzeler EA, et al. Selective and specific inhibition of the plasmodium falciparum lysyl-tRNA synthetase by the fungal secondary metabolite cladosporin. Cell Host & Microbe. 11: 654-63. PMID 22704625 DOI: 10.1016/J.Chom.2012.04.015 |
0.748 |
|
| 2012 |
Nagle A, Wu T, Kuhen K, Gagaring K, Borboa R, Francek C, Chen Z, Plouffe D, Lin X, Caldwell C, Ek J, Skolnik S, Liu F, Wang J, Chang J, ... ... Winzeler EA, et al. Imidazolopiperazines: lead optimization of the second-generation antimalarial agents. Journal of Medicinal Chemistry. 55: 4244-73. PMID 22524250 DOI: 10.1021/Jm300041E |
0.321 |
|
| 2012 |
Delves M, Plouffe D, Scheurer C, Meister S, Wittlin S, Winzeler EA, Sinden RE, Leroy D. The activities of current antimalarial drugs on the life cycle stages of Plasmodium: a comparative study with human and rodent parasites. Plos Medicine. 9: e1001169. PMID 22363211 DOI: 10.1371/Journal.Pmed.1001169 |
0.477 |
|
| 2011 |
Meister S, Plouffe DM, Kuhen KL, Bonamy GM, Wu T, Barnes SW, Bopp SE, Borboa R, Bright AT, Che J, Cohen S, Dharia NV, Gagaring K, Gettayacamin M, Gordon P, ... ... Winzeler EA, et al. Imaging of Plasmodium liver stages to drive next-generation antimalarial drug discovery. Science (New York, N.Y.). 334: 1372-7. PMID 22096101 DOI: 10.1126/Science.1211936 |
0.833 |
|
| 2011 |
Nam TG, McNamara CW, Bopp S, Dharia NV, Meister S, Bonamy GM, Plouffe DM, Kato N, McCormack S, Bursulaya B, Ke H, Vaidya AB, Schultz PG, Winzeler EA. A chemical genomic analysis of decoquinate, a Plasmodium falciparum cytochrome b inhibitor. Acs Chemical Biology. 6: 1214-22. PMID 21866942 DOI: 10.1021/Cb200105D |
0.843 |
|
| 2011 |
Bright AT, Winzeler EA. Noncoding RNA, antigenic variation, and the virulence genes of Plasmodium falciparum. Bmc Biology. 9: 50. PMID 21771351 DOI: 10.1186/1741-7007-9-50 |
0.372 |
|
| 2011 |
McNamara C, Winzeler EA. Target identification and validation of novel antimalarials. Future Microbiology. 6: 693-704. PMID 21707315 DOI: 10.2217/Fmb.11.45 |
0.74 |
|
| 2011 |
Wu T, Nagle A, Kuhen K, Gagaring K, Borboa R, Francek C, Chen Z, Plouffe D, Goh A, Lakshminarayana SB, Wu J, Ang HQ, Zeng P, Kang ML, Tan W, ... ... Winzeler E, et al. Imidazolopiperazines: hit to lead optimization of new antimalarial agents. Journal of Medicinal Chemistry. 54: 5116-30. PMID 21644570 DOI: 10.1021/Jm2003359 |
0.426 |
|
| 2011 |
Eastman RT, Dharia NV, Winzeler EA, Fidock DA. Piperaquine resistance is associated with a copy number variation on chromosome 5 in drug-pressured Plasmodium falciparum parasites. Antimicrobial Agents and Chemotherapy. 55: 3908-16. PMID 21576453 DOI: 10.1128/Aac.01793-10 |
0.752 |
|
| 2011 |
Istvan ES, Dharia NV, Bopp SE, Gluzman I, Winzeler EA, Goldberg DE. Validation of isoleucine utilization targets in Plasmodium falciparum. Proceedings of the National Academy of Sciences of the United States of America. 108: 1627-32. PMID 21205898 DOI: 10.1073/Pnas.1011560108 |
0.864 |
|
| 2010 |
Dharia NV, Bright AT, Westenberger SJ, Barnes SW, Batalov S, Kuhen K, Borboa R, Federe GC, McClean CM, Vinetz JM, Neyra V, Llanos-Cuentas A, Barnwell JW, Walker JR, Winzeler EA. Whole-genome sequencing and microarray analysis of ex vivo Plasmodium vivax reveal selective pressure on putative drug resistance genes. Proceedings of the National Academy of Sciences of the United States of America. 107: 20045-50. PMID 21037109 DOI: 10.1073/Pnas.1003776107 |
0.769 |
|
| 2010 |
Dharia NV, Plouffe D, Bopp SE, González-Páez GE, Lucas C, Salas C, Soberon V, Bursulaya B, Kochel TJ, Bacon DJ, Winzeler EA. Genome scanning of Amazonian Plasmodium falciparum shows subtelomeric instability and clindamycin-resistant parasites. Genome Research. 20: 1534-44. PMID 20829224 DOI: 10.1101/Gr.105163.110 |
0.84 |
|
| 2010 |
Rottmann M, McNamara C, Yeung BK, Lee MC, Zou B, Russell B, Seitz P, Plouffe DM, Dharia NV, Tan J, Cohen SB, Spencer KR, González-Páez GE, Lakshminarayana SB, Goh A, ... ... Winzeler EA, et al. Spiroindolones, a potent compound class for the treatment of malaria. Science (New York, N.Y.). 329: 1175-80. PMID 20813948 DOI: 10.1126/Science.1193225 |
0.833 |
|
| 2010 |
Deng X, Nagle A, Wu T, Sakata T, Henson K, Chen Z, Kuhen K, Plouffe D, Winzeler E, Adrian F, Tuntland T, Chang J, Simerson S, Howard S, Ek J, et al. Discovery of novel 1H-imidazol-2-yl-pyrimidine-4,6-diamines as potential antimalarials. Bioorganic & Medicinal Chemistry Letters. 20: 4027-31. PMID 20610151 DOI: 10.1016/J.Bmcl.2010.05.095 |
0.498 |
|
| 2010 |
Zhang M, Fennell C, Ranford-Cartwright L, Sakthivel R, Gueirard P, Meister S, Caspi A, Doerig C, Nussenzweig RS, Tuteja R, Sullivan WJ, Roos DS, Fontoura BM, Ménard R, Winzeler EA, et al. The Plasmodium eukaryotic initiation factor-2alpha kinase IK2 controls the latency of sporozoites in the mosquito salivary glands. The Journal of Experimental Medicine. 207: 1465-74. PMID 20584882 DOI: 10.1084/Jem.20091975 |
0.394 |
|
| 2010 |
Yeung BK, Zou B, Rottmann M, Lakshminarayana SB, Ang SH, Leong SY, Tan J, Wong J, Keller-Maerki S, Fischli C, Goh A, Schmitt EK, Krastel P, Francotte E, Kuhen K, ... ... Winzeler EA, et al. Spirotetrahydro beta-carbolines (spiroindolones): a new class of potent and orally efficacious compounds for the treatment of malaria. Journal of Medicinal Chemistry. 53: 5155-64. PMID 20568778 DOI: 10.1021/Jm100410F |
0.369 |
|
| 2010 |
Bopp SE, Ramachandran V, Henson K, Luzader A, Lindstrom M, Spooner M, Steffy BM, Suzuki O, Janse C, Waters AP, Zhou Y, Wiltshire T, Winzeler EA. Genome wide analysis of inbred mouse lines identifies a locus containing Ppar-gamma as contributing to enhanced malaria survival. Plos One. 5: e10903. PMID 20531941 DOI: 10.1371/Journal.Pone.0010903 |
0.786 |
|
| 2010 |
Dvorin JD, Martyn DC, Patel SD, Grimley JS, Collins CR, Hopp CS, Bright AT, Westenberger S, Winzeler E, Blackman MJ, Baker DA, Wandless TJ, Duraisingh MT. A plant-like kinase in Plasmodium falciparum regulates parasite egress from erythrocytes. Science (New York, N.Y.). 328: 910-2. PMID 20466936 DOI: 10.1126/Science.1188191 |
0.402 |
|
| 2010 |
Westenberger SJ, McClean CM, Chattopadhyay R, Dharia NV, Carlton JM, Barnwell JW, Collins WE, Hoffman SL, Zhou Y, Vinetz JM, Winzeler EA. A systems-based analysis of Plasmodium vivax lifecycle transcription from human to mosquito. Plos Neglected Tropical Diseases. 4: e653. PMID 20386602 DOI: 10.1371/Journal.Pntd.0000653 |
0.733 |
|
| 2010 |
Dharia NV, Chatterjee A, Winzeler EA. Genomics and systems biology in malaria drug discovery. Current Opinion in Investigational Drugs (London, England : 2000). 11: 131-8. PMID 20112162 |
0.745 |
|
| 2009 |
Westenberger SJ, Cui L, Dharia N, Winzeler E, Cui L. Genome-wide nucleosome mapping of Plasmodium falciparum reveals histone-rich coding and histone-poor intergenic regions and chromatin remodeling of core and subtelomeric genes. Bmc Genomics. 10: 610. PMID 20015349 DOI: 10.1186/1471-2164-10-610 |
0.681 |
|
| 2009 |
Wu T, Nagle A, Sakata T, Henson K, Borboa R, Chen Z, Kuhen K, Plouffe D, Winzeler E, Adrian F, Tuntland T, Chang J, Simerson S, Howard S, Ek J, et al. Cell-based optimization of novel benzamides as potential antimalarial leads. Bioorganic & Medicinal Chemistry Letters. 19: 6970-4. PMID 19879133 DOI: 10.1016/J.Bmcl.2009.10.050 |
0.363 |
|
| 2009 |
Winzeler EA. Advances in parasite genomics: from sequences to regulatory networks. Plos Pathogens. 5: e1000649. PMID 19876395 DOI: 10.1371/Journal.Ppat.1000649 |
0.444 |
|
| 2009 |
Dharia NV, Sidhu AB, Cassera MB, Westenberger SJ, Bopp SE, Eastman RT, Plouffe D, Batalov S, Park DJ, Volkman SK, Wirth DF, Zhou Y, Fidock DA, Winzeler EA. Use of high-density tiling microarrays to identify mutations globally and elucidate mechanisms of drug resistance in Plasmodium falciparum. Genome Biology. 10: R21. PMID 19216790 DOI: 10.1186/Gb-2009-10-2-R21 |
0.843 |
|
| 2008 |
Le Roch KG, Johnson JR, Ahiboh H, Chung DW, Prudhomme J, Plouffe D, Henson K, Zhou Y, Witola W, Yates JR, Mamoun CB, Winzeler EA, Vial H. A systematic approach to understand the mechanism of action of the bisthiazolium compound T4 on the human malaria parasite, Plasmodium falciparum. Bmc Genomics. 9: 513. PMID 18973684 DOI: 10.1186/1471-2164-9-513 |
0.714 |
|
| 2008 |
Winzeler EA. Malaria research in the post-genomic era. Nature. 455: 751-6. PMID 18843360 DOI: 10.1038/Nature07361 |
0.413 |
|
| 2008 |
Plouffe D, Brinker A, McNamara C, Henson K, Kato N, Kuhen K, Nagle A, Adrián F, Matzen JT, Anderson P, Nam TG, Gray NS, Chatterjee A, Janes J, Yan SF, ... ... Winzeler EA, et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proceedings of the National Academy of Sciences of the United States of America. 105: 9059-64. PMID 18579783 DOI: 10.1073/Pnas.0802982105 |
0.719 |
|
| 2008 |
Kato N, Sakata T, Breton G, Le Roch KG, Nagle A, Andersen C, Bursulaya B, Henson K, Johnson J, Kumar KA, Marr F, Mason D, McNamara C, Plouffe D, Ramachandran V, ... ... Winzeler EA, et al. Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility. Nature Chemical Biology. 4: 347-56. PMID 18454143 DOI: 10.1038/Nchembio.87 |
0.8 |
|
| 2008 |
Zhou Y, Ramachandran V, Kumar KA, Westenberger S, Refour P, Zhou B, Li F, Young JA, Chen K, Plouffe D, Henson K, Nussenzweig V, Carlton J, Vinetz JM, Duraisingh MT, ... Winzeler EA, et al. Evidence-based annotation of the malaria parasite's genome using comparative expression profiling. Plos One. 3: e1570. PMID 18270564 DOI: 10.1371/Journal.Pone.0001570 |
0.669 |
|
| 2008 |
Young JA, Johnson JR, Benner C, Yan SF, Chen K, Le Roch KG, Zhou Y, Winzeler EA. In silico discovery of transcription regulatory elements in Plasmodium falciparum. Bmc Genomics. 9: 70. PMID 18257930 DOI: 10.1186/1471-2164-9-70 |
0.742 |
|
| 2008 |
Singh AP, Buscaglia CA, Wang Q, Levay A, Nussenzweig DR, Walker JR, Winzeler EA, Fujii H, Fontoura BMA, Nussenzweig V. Plasmodium Circumsporozoite Protein Promotes the Development of the Liver Stages of the Parasite (DOI:10.1016/j.cell.2007.09.013) Cell. 133: 375. DOI: 10.1016/J.Cell.2008.03.022 |
0.37 |
|
| 2007 |
Daily JP, Scanfeld D, Pochet N, Le Roch K, Plouffe D, Kamal M, Sarr O, Mboup S, Ndir O, Wypij D, Levasseur K, Thomas E, Tamayo P, Dong C, Zhou Y, ... ... Winzeler EA, et al. Distinct physiological states of Plasmodium falciparum in malaria-infected patients. Nature. 450: 1091-5. PMID 18046333 DOI: 10.1038/Nature06311 |
0.436 |
|
| 2007 |
Sakata T, Winzeler EA. Genomics, systems biology and drug development for infectious diseases. Molecular Biosystems. 3: 841-8. PMID 18000561 DOI: 10.1039/B703924G |
0.462 |
|
| 2007 |
Singh AP, Buscaglia CA, Wang Q, Levay A, Nussenzweig DR, Walker JR, Winzeler EA, Fujii H, Fontoura BM, Nussenzweig V. Plasmodium circumsporozoite protein promotes the development of the liver stages of the parasite. Cell. 131: 492-504. PMID 17981117 DOI: 10.1016/J.Cell.2007.09.013 |
0.427 |
|
| 2007 |
Kumar KA, Garcia CR, Chandran VR, Van Rooijen N, Zhou Y, Winzeler E, Nussenzweig V. Exposure of Plasmodium sporozoites to the intracellular concentration of potassium enhances infectivity and reduces cell passage activity. Molecular and Biochemical Parasitology. 156: 32-40. PMID 17714805 DOI: 10.1016/J.Molbiopara.2007.07.004 |
0.328 |
|
| 2007 |
Deitsch K, Duraisingh M, Dzikowski R, Gunasekera A, Khan S, Le Roch K, Llinás M, Mair G, McGovern V, Roos D, Shock J, Sims J, Wiegand R, Winzeler E. Mechanisms of gene regulation in Plasmodium. The American Journal of Tropical Medicine and Hygiene. 77: 201-8. PMID 17690387 |
0.568 |
|
| 2007 |
Zhou Y, Zhou B, Chen K, Yan SF, King FJ, Jiang S, Winzeler EA. Large-scale annotation of small-molecule libraries using public databases. Journal of Chemical Information and Modeling. 47: 1386-94. PMID 17608408 DOI: 10.1021/Ci700092V |
0.366 |
|
| 2007 |
Gunasekera AM, Myrick A, Le Roch K, Winzeler E, Wirth DF. Plasmodium falciparum: genome wide perturbations in transcript profiles among mixed stage cultures after chloroquine treatment. Experimental Parasitology. 117: 87-92. PMID 17475254 DOI: 10.1016/J.Exppara.2007.03.001 |
0.674 |
|
| 2007 |
Gunasekera AM, Myrick A, Militello KT, Sims JS, Dong CK, Gierahn T, Le Roch K, Winzeler E, Wirth DF. Regulatory motifs uncovered among gene expression clusters in Plasmodium falciparum. Molecular and Biochemical Parasitology. 153: 19-30. PMID 17307259 DOI: 10.1016/J.Molbiopara.2007.01.011 |
0.657 |
|
| 2006 |
Kidgell C, Winzeler EA. Using the genome to dissect the molecular basis of drug resistance. Future Microbiology. 1: 185-99. PMID 17661664 DOI: 10.2217/17460913.1.2.185 |
0.486 |
|
| 2006 |
Kidgell C, Volkman SK, Daily J, Borevitz JO, Plouffe D, Zhou Y, Johnson JR, Le Roch K, Sarr O, Ndir O, Mboup S, Batalov S, Wirth DF, Winzeler EA. A systematic map of genetic variation in Plasmodium falciparum. Plos Pathogens. 2: e57. PMID 16789840 DOI: 10.1371/Journal.Ppat.0020057 |
0.727 |
|
| 2006 |
Kidgell C, Volkman SK, Daily J, Borevitz JO, Plouffe D, Zhou Y, Johnson JR, Roch KGL, Sarr O, Ndir O, Mboup S, Batalov S, Wirth DF, Winzeler EA. Correction: A Systematic Map of Genetic Variation in Plasmodium falciparum Plos Pathogens. 2: e96. DOI: 10.1371/Journal.Ppat.0020096 |
0.332 |
|
| 2005 |
Carret CK, Horrocks P, Konfortov B, Winzeler E, Qureshi M, Newbold C, Ivens A. Microarray-based comparative genomic analyses of the human malaria parasite Plasmodium falciparum using Affymetrix arrays. Molecular and Biochemical Parasitology. 144: 177-86. PMID 16174539 DOI: 10.1016/J.Molbiopara.2005.08.010 |
0.402 |
|
| 2005 |
Stubbs J, Simpson KM, Triglia T, Plouffe D, Tonkin CJ, Duraisingh MT, Maier AG, Winzeler EA, Cowman AF. Molecular mechanism for switching of P. falciparum invasion pathways into human erythrocytes. Science (New York, N.Y.). 309: 1384-7. PMID 16123303 DOI: 10.1126/Science.1115257 |
0.366 |
|
| 2005 |
Young JA, Fivelman QL, Blair PL, de la Vega P, Le Roch KG, Zhou Y, Carucci DJ, Baker DA, Winzeler EA. The Plasmodium falciparum sexual development transcriptome: a microarray analysis using ontology-based pattern identification. Molecular and Biochemical Parasitology. 143: 67-79. PMID 16005087 DOI: 10.1016/J.Molbiopara.2005.05.007 |
0.729 |
|
| 2005 |
Kidgell C, Winzeler EA. Elucidating genetic diversity with oligonucleotide arrays. Chromosome Research : An International Journal On the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology. 13: 225-35. PMID 15868417 DOI: 10.1007/S10577-005-1503-6 |
0.301 |
|
| 2005 |
Daily JP, Le Roch KG, Sarr O, Ndiaye D, Lukens A, Zhou Y, Ndir O, Mboup S, Sultan A, Winzeler EA, Wirth DF. In vivo transcriptome of Plasmodium falciparum reveals overexpression of transcripts that encode surface proteins. The Journal of Infectious Diseases. 191: 1196-203. PMID 15747257 DOI: 10.1086/428289 |
0.693 |
|
| 2005 |
Young JA, Winzeler EA. Using expression information to discover new drug and vaccine targets in the malaria parasite Plasmodium falciparum. Pharmacogenomics. 6: 17-26. PMID 15723602 DOI: 10.1517/14622416.6.1.17 |
0.683 |
|
| 2005 |
Zhou Y, Young JA, Santrosyan A, Chen K, Yan SF, Winzeler EA. In silico gene function prediction using ontology-based pattern identification. Bioinformatics (Oxford, England). 21: 1237-45. PMID 15531612 DOI: 10.1093/Bioinformatics/Bti111 |
0.57 |
|
| 2005 |
LE ROCH KG, ZHOU Y, JOHNSON JR, YOUNG J, KIDGELL C, WINZELER E. Functional Genomics of Plasmodium falciparum: a new approach for identifying therapeutic targets against malaria The Journal of Eukaryotic Microbiology. 52: 28S-34S. DOI: 10.1111/J.1550-7408.2005.05202003_3_12.X |
0.649 |
|
| 2004 |
O'Neill BM, Hanway D, Winzeler EA, Romesberg FE. Coordinated functions of WSS1, PSY2 and TOF1 in the DNA damage response. Nucleic Acids Research. 32: 6519-30. PMID 15598824 DOI: 10.1093/Nar/Gkh994 |
0.318 |
|
| 2004 |
Le Roch KG, Johnson JR, Florens L, Zhou Y, Santrosyan A, Grainger M, Yan SF, Williamson KC, Holder AA, Carucci DJ, Yates JR, Winzeler EA. Global analysis of transcript and protein levels across the Plasmodium falciparum life cycle. Genome Research. 14: 2308-18. PMID 15520293 DOI: 10.1101/Gr.2523904 |
0.631 |
|
| 2004 |
Daily JP, Le Roch KG, Sarr O, Fang X, Zhou Y, Ndir O, Mboup S, Sultan A, Winzeler EA, Wirth DF. In vivo transcriptional profiling of Plasmodium falciparum. Malaria Journal. 3: 30. PMID 15296511 DOI: 10.1186/1475-2875-3-30 |
0.667 |
|
| 2004 |
Sam-Yellowe TY, Florens L, Johnson JR, Wang T, Drazba JA, Le Roch KG, Zhou Y, Batalov S, Carucci DJ, Winzeler EA, Yates JR. A Plasmodium gene family encoding Maurer's cleft membrane proteins: structural properties and expression profiling. Genome Research. 14: 1052-9. PMID 15140830 DOI: 10.1101/Gr.2126104 |
0.645 |
|
| 2003 |
Le Roch KG, Zhou Y, Blair PL, Grainger M, Moch JK, Haynes JD, De La Vega P, Holder AA, Batalov S, Carucci DJ, Winzeler EA. Discovery of gene function by expression profiling of the malaria parasite life cycle. Science (New York, N.Y.). 301: 1503-8. PMID 12893887 DOI: 10.1126/Science.1087025 |
0.707 |
|
| 2003 |
Borevitz JO, Liang D, Plouffe D, Chang HS, Zhu T, Weigel D, Berry CC, Winzeler E, Chory J. Large-scale identification of single-feature polymorphisms in complex genomes. Genome Research. 13: 513-23. PMID 12618383 DOI: 10.1101/Gr.541303 |
0.366 |
|
| 2003 |
Winzeler EA, Castillo-Davis CI, Oshiro G, Liang D, Richards DR, Zhou Y, Hartl DL. Genetic diversity in yeast assessed with whole-genome oligonucleotide arrays. Genetics. 163: 79-89. PMID 12586698 |
0.661 |
|
| 2002 |
Le Roch KG, Zhou Y, Batalov S, Winzeler EA. Monitoring the chromosome 2 intraerythrocytic transcriptome of Plasmodium falciparum using oligonucleotide arrays. The American Journal of Tropical Medicine and Hygiene. 67: 233-43. PMID 12408661 DOI: 10.4269/Ajtmh.2002.67.233 |
0.622 |
|
| 2002 |
Williams RM, Primig M, Washburn BK, Winzeler EA, Bellis M, Sarrauste de Menthiere C, Davis RW, Esposito RE. The Ume6 regulon coordinates metabolic and meiotic gene expression in yeast. Proceedings of the National Academy of Sciences of the United States of America. 99: 13431-6. PMID 12370439 DOI: 10.1073/Pnas.202495299 |
0.48 |
|
| 2002 |
Volkman SK, Hartl DL, Wirth DF, Nielsen KM, Choi M, Batalov S, Zhou Y, Plouffe D, Le Roch KG, Abagyan R, Winzeler EA. Excess polymorphisms in genes for membrane proteins in Plasmodium falciparum. Science (New York, N.Y.). 298: 216-8. PMID 12364807 DOI: 10.1126/Science.1075642 |
0.603 |
|
| 2002 |
Grünenfelder B, Winzeler EA. Treasures and traps in genome-wide data sets: case examples from yeast. Nature Reviews. Genetics. 3: 653-61. PMID 12209140 DOI: 10.1038/Nrg886 |
0.306 |
|
| 2002 |
Que QQ, Winzeler EA. Large-scale mutagenesis and functional genomics in yeast. Functional & Integrative Genomics. 2: 193-8. PMID 12192592 DOI: 10.1007/S10142-002-0057-3 |
0.349 |
|
| 2002 |
Oshiro G, Wodicka LM, Washburn MP, Yates JR, Lockhart DJ, Winzeler EA. Parallel identification of new genes in Saccharomyces cerevisiae. Genome Research. 12: 1210-20. PMID 12176929 DOI: 10.1101/Gr.226802 |
0.35 |
|
| 2002 |
Hanway D, Chin JK, Xia G, Oshiro G, Winzeler EA, Romesberg FE. Previously uncharacterized genes in the UV- and MMS-induced DNA damage response in yeast. Proceedings of the National Academy of Sciences of the United States of America. 99: 10605-10. PMID 12149442 DOI: 10.1073/Pnas.152264899 |
0.305 |
|
| 2002 |
Giaever G, Chu AM, Ni L, Connelly C, Riles L, Véronneau S, Dow S, Lucau-Danila A, Anderson K, André B, Arkin AP, Astromoff A, El-Bakkoury M, Bangham R, Benito R, ... ... Winzeler EA, et al. Functional profiling of the Saccharomyces cerevisiae genome. Nature. 418: 387-91. PMID 12140549 DOI: 10.1038/Nature00935 |
0.776 |
|
| 2002 |
Hartl DL, Volkman SK, Nielsen KM, Barry AE, Day KP, Wirth DF, Winzeler EA. The paradoxical population genetics of Plasmodium falciparum. Trends in Parasitology. 18: 266-72. PMID 12036741 DOI: 10.1016/S1471-4922(02)02268-7 |
0.363 |
|
| 2001 |
Karlyshev AV, Oyston PC, Williams K, Clark GC, Titball RW, Winzeler EA, Wren BW. Application of high-density array-based signature-tagged mutagenesis to discover novel Yersinia virulence-associated genes. Infection and Immunity. 69: 7810-9. PMID 11705963 DOI: 10.1128/Iai.69.12.7810-7819.2001 |
0.37 |
|
| 2001 |
Raghuraman MK, Winzeler EA, Collingwood D, Hunt S, Wodicka L, Conway A, Lockhart DJ, Davis RW, Brewer BJ, Fangman WL. Replication dynamics of the yeast genome. Science (New York, N.Y.). 294: 115-21. PMID 11588253 DOI: 10.1126/Science.294.5540.115 |
0.463 |
|
| 2000 |
Primig M, Williams RM, Winzeler EA, Tevzadze GG, Conway AR, Hwang SY, Davis RW, Esposito RE. The core meiotic transcriptome in budding yeasts. Nature Genetics. 26: 415-23. PMID 11101837 DOI: 10.1038/82539 |
0.471 |
|
| 2000 |
Winzeler EA, Liang H, Shoemaker DD, Davis RW. Functional analysis of the yeast genome by precise deletion and parallel phenotypic characterization. Novartis Foundation Symposium. 229: 105-9; discussion 10. PMID 11084935 DOI: 10.1002/047084664X.Ch14 |
0.484 |
|
| 2000 |
Lockhart DJ, Winzeler EA. Genomics, gene expression and DNA arrays. Nature. 405: 827-36. PMID 10866209 DOI: 10.1038/35015701 |
0.31 |
|
| 2000 |
Karlyshev AV, Oyston PC, Williams K, Titball RW, Davis R, Winzeler EA, Wren BW. Development of high-density DNA array based signature-tagged mutagenesis and its application for the discovery of novel Y. pseudotuberculosis virulence-associated genes Biochemical Society Transactions. 28: A232-A232. DOI: 10.1042/Bst028A232 |
0.469 |
|
| 1999 |
Winzeler EA, Lee B, McCusker JH, Davis RW. Whole genome genetic-typing in yeast using high-density oligonucleotide arrays. Parasitology. 118: S73-80. PMID 10466139 DOI: 10.1017/S0031182099004047 |
0.481 |
|
| 1999 |
Winzeler EA, Shoemaker DD, Astromoff A, Liang H, Anderson K, Andre B, Bangham R, Benito R, Boeke JD, Bussey H, Chu AM, Connelly C, Davis K, Dietrich F, Dow SW, et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science (New York, N.Y.). 285: 901-6. PMID 10436161 DOI: 10.1126/Science.285.5429.901 |
0.789 |
|
| 1999 |
Winzeler EA, Schena M, Davis RW. Fluorescence-based expression monitoring using microarrays. Methods in Enzymology. 306: 3-18. PMID 10432445 DOI: 10.1016/S0076-6879(99)06003-6 |
0.46 |
|
| 1999 |
Giaever G, Shoemaker DD, Jones TW, Liang H, Winzeler EA, Astromoff A, Davis RW. Genomic profiling of drug sensitivities via induced haploinsufficiency. Nature Genetics. 21: 278-83. PMID 10080179 DOI: 10.1038/6791 |
0.704 |
|
| 1998 |
Winzeler EA, Richards DR, Conway AR, Goldstein AL, Kalman S, McCullough MJ, McCusker JH, Stevens DA, Wodicka L, Lockhart DJ, Davis RW. Direct allelic variation scanning of the yeast genome. Science (New York, N.Y.). 281: 1194-7. PMID 9712584 DOI: 10.1126/Science.281.5380.1194 |
0.735 |
|
| 1998 |
Cho RJ, Campbell MJ, Winzeler EA, Steinmetz L, Conway A, Wodicka L, Wolfsberg TG, Gabrielian AE, Landsman D, Lockhart DJ, Davis RW. A genome-wide transcriptional analysis of the mitotic cell cycle. Molecular Cell. 2: 65-73. PMID 9702192 DOI: 10.1016/S1097-2765(00)80114-8 |
0.751 |
|
| 1997 |
Winzeler EA, Davis RW. Functional analysis of the yeast genome. Current Opinion in Genetics & Development. 7: 771-6. PMID 9468786 DOI: 10.1042/Bst028A112B |
0.493 |
|
| 1997 |
Winzeler E, Wheeler R, Shapiro L. Transcriptional analysis of the Caulobacter 4.5 S RNA ffs gene and the physiological basis of an ffs mutant with a Ts phenotype. Journal of Molecular Biology. 272: 665-76. PMID 9368649 DOI: 10.1006/Jmbi.1997.1261 |
0.48 |
|
| 1997 |
Winzeler E, Shapiro L. Translation of the leaderless Caulobacter dnaX mRNA. Journal of Bacteriology. 179: 3981-8. PMID 9190815 DOI: 10.1128/Jb.179.12.3981-3988.1997 |
0.461 |
|
| 1996 |
Winzeler E, Shapiro L. A novel promoter motif for Caulobacter cell cycle-controlled DNA replication genes. Journal of Molecular Biology. 264: 412-25. PMID 8969294 DOI: 10.1006/Jmbi.1996.0650 |
0.48 |
|
| 1995 |
Winzeler E, Shapiro L. Use of flow cytometry to identify a Caulobacter 4.5 S RNA temperature-sensitive mutant defective in the cell cycle. Journal of Molecular Biology. 251: 346-65. PMID 7544413 DOI: 10.1006/Jmbi.1995.0439 |
0.482 |
|
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