| Year |
Citation |
Score |
| 2021 |
Visioli F, Ingram A, Beckman JS, Magnusson KR, Hagen TM. Strategies to protect against age-related mitochondrial decay: Do natural products and their derivatives help? Free Radical Biology & Medicine. 178: 330-346. PMID 34890770 DOI: 10.1016/j.freeradbiomed.2021.12.008 |
0.348 |
|
| 2020 |
Rodríguez E, Hakkou M, Hagen TM, Lemieux H, Blier PU. Divergences in the control of mitochondrial respiration are associated with lifespan variation in marine bivalves. The Journals of Gerontology. Series a, Biological Sciences and Medical Sciences. PMID 33257932 DOI: 10.1093/gerona/glaa301 |
0.303 |
|
| 2019 |
Thomas NO, Shay KP, Hagen TM. Age-related loss of mitochondrial glutathione exacerbates menadione-induced inhibition of Complex I. Redox Biology. 22: 101155. PMID 30851669 DOI: 10.1016/J.Redox.2019.101155 |
0.486 |
|
| 2016 |
Thomas NO, Shay KP, Kelley AR, Butler JA, Hagen TM. Glutathione maintenance mitigates age-related susceptibility to redox cycling agents. Redox Biology. 10: 45-52. PMID 27687220 DOI: 10.1016/J.Redox.2016.09.010 |
0.442 |
|
| 2015 |
Smith EJ, Shay KP, Thomas NO, Butler JA, Finlay LF, Hagen TM. Age-related loss of hepatic Nrf2 protein homeostasis: Potential role for heightened expression of miR-146a. Free Radical Biology & Medicine. PMID 26549877 DOI: 10.1016/J.Freeradbiomed.2015.11.003 |
0.438 |
|
| 2014 |
Keith D, Finlay L, Butler J, Gómez L, Smith E, Moreau R, Hagen T. Lipoic acid entrains the hepatic circadian clock and lipid metabolic proteins that have been desynchronized with advanced age. Biochemical and Biophysical Research Communications. 450: 324-9. PMID 24944020 DOI: 10.1016/J.Bbrc.2014.05.112 |
0.383 |
|
| 2012 |
Keith DJ, Butler JA, Bemer B, Dixon B, Johnson S, Garrard M, Sudakin DL, Christensen JM, Pereira C, Hagen TM. Age and gender dependent bioavailability of R- and R,S-α-lipoic acid: a pilot study. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 66: 199-206. PMID 22609537 DOI: 10.1016/J.Phrs.2012.05.002 |
0.33 |
|
| 2012 |
Shay KP, Michels AJ, Li W, Kong AN, Hagen TM. Cap-independent Nrf2 translation is part of a lipoic acid-stimulated detoxification stress response. Biochimica Et Biophysica Acta. 1823: 1102-9. PMID 22521877 DOI: 10.1016/J.Bbamcr.2012.04.002 |
0.355 |
|
| 2012 |
Gómez LA, Hagen TM. Age-related decline in mitochondrial bioenergetics: does supercomplex destabilization determine lower oxidative capacity and higher superoxide production? Seminars in Cell & Developmental Biology. 23: 758-67. PMID 22521482 DOI: 10.1016/J.Semcdb.2012.04.002 |
0.465 |
|
| 2012 |
Gómez LA, Heath SH, Hagen TM. Acetyl-L-carnitine supplementation reverses the age-related decline in carnitine palmitoyltransferase 1 (CPT1) activity in interfibrillar mitochondria without changing the L-carnitine content in the rat heart. Mechanisms of Ageing and Development. 133: 99-106. PMID 22322067 DOI: 10.1016/J.Mad.2012.01.007 |
0.437 |
|
| 2012 |
Shenvi SV, Smith E, Hagen TM. Identification of age-specific Nrf2 binding to a novel antioxidant response element locus in the Gclc promoter: a compensatory means for the loss of glutathione synthetic capacity in the aging rat liver? Aging Cell. 11: 297-304. PMID 22212472 DOI: 10.1111/J.1474-9726.2011.00788.X |
0.769 |
|
| 2012 |
Finlay LA, Michels AJ, Butler JA, Smith EJ, Monette JS, Moreau RF, Petersen SK, Frei B, Hagen TM. R-α-lipoic acid does not reverse hepatic inflammation of aging, but lowers lipid anabolism, while accentuating circadian rhythm transcript profiles. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 302: R587-97. PMID 22049228 DOI: 10.1152/Ajpregu.00393.2011 |
0.755 |
|
| 2011 |
Monette JS, Gómez LA, Moreau RF, Dunn KC, Butler JA, Finlay LA, Michels AJ, Shay KP, Smith EJ, Hagen TM. (R)-α-Lipoic acid treatment restores ceramide balance in aging rat cardiac mitochondria. Pharmacological Research. 63: 23-9. PMID 20934512 DOI: 10.1016/J.Phrs.2010.09.007 |
0.784 |
|
| 2011 |
Monette JS, Gómez LA, Moreau RF, Bemer BA, Taylor AW, Hagen TM. Corrigendum to "Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations" [Biochem. Biophys. Res. Commun. 398 (2010) 272-277] Biochemical and Biophysical Research Communications. 404: 1111. DOI: 10.1016/J.Bbrc.2010.11.073 |
0.745 |
|
| 2010 |
Shay KP, Smith EJ, Hagen TM. Transcription factor Nrf2: examination of nuclear protein levels by immunoblotting and promoter response element binding by chromatin immunoprecipitation (ChIP). Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. Unit17.13. PMID 23045018 DOI: 10.1002/0471140856.Tx1713S45 |
0.378 |
|
| 2010 |
Li L, Smith A, Hagen TM, Frei B. Vascular oxidative stress and inflammation increase with age: ameliorating effects of alpha-lipoic acid supplementation. Annals of the New York Academy of Sciences. 1203: 151-9. PMID 20716298 DOI: 10.1111/j.1749-6632.2010.05555.x |
0.33 |
|
| 2010 |
Monette JS, Gómez LA, Moreau RF, Bemer BA, Taylor AW, Hagen TM. Characteristics of the rat cardiac sphingolipid pool in two mitochondrial subpopulations. Biochemical and Biophysical Research Communications. 398: 272-7. PMID 20599536 DOI: 10.1016/J.Bbrc.2010.06.077 |
0.757 |
|
| 2010 |
Finlay L, Butler JA, Michels AJ, Smith E, Monette JS, Moreau RF, Peterson-Shay K, Hobbs D, Frei B, Hagen TM. Aging Promotes a Necro-inflammatory Phenotype and Increased Lipid Synthesis, Which is Attenuated by Chronic R-α-lipoic acid Supplementation Free Radical Biology and Medicine. 49: S79-S80. DOI: 10.1016/J.Freeradbiomed.2010.10.198 |
0.328 |
|
| 2009 |
Gómez LA, Monette JS, Chavez JD, Maier CS, Hagen TM. Supercomplexes of the mitochondrial electron transport chain decline in the aging rat heart. Archives of Biochemistry and Biophysics. 490: 30-5. PMID 19679098 DOI: 10.1016/J.Abb.2009.08.002 |
0.778 |
|
| 2009 |
Shay KP, Moreau RF, Smith EJ, Smith AR, Hagen TM. Alpha-lipoic acid as a dietary supplement: molecular mechanisms and therapeutic potential. Biochimica Et Biophysica Acta. 1790: 1149-60. PMID 19664690 DOI: 10.1016/J.Bbagen.2009.07.026 |
0.372 |
|
| 2009 |
Shenvi SV, Smith EJ, Hagen TM. Transcriptional regulation of rat gamma-glutamate cysteine ligase catalytic subunit gene is mediated through a distal antioxidant response element. Pharmacological Research. 60: 229-36. PMID 19540342 DOI: 10.1016/J.Phrs.2009.06.003 |
0.732 |
|
| 2009 |
Butler JA, Hagen TM, Moreau R. Lipoic acid improves hypertriglyceridemia by stimulating triacylglycerol clearance and downregulating liver triacylglycerol secretion. Archives of Biochemistry and Biophysics. 485: 63-71. PMID 19232511 DOI: 10.1016/J.Abb.2009.01.024 |
0.366 |
|
| 2009 |
Shay KP, Hagen TM. Age-associated impairment of Akt phosphorylation in primary rat hepatocytes is remediated by alpha-lipoic acid through PI3 kinase, PTEN, and PP2A. Biogerontology. 10: 443-56. PMID 18931933 DOI: 10.1007/S10522-008-9187-X |
0.367 |
|
| 2008 |
Shenvi SV, Dixon BM, Petersen Shay K, Hagen TM. A rat primary hepatocyte culture model for aging studies. Current Protocols in Toxicology / Editorial Board, Mahin D. Maines (Editor-in-Chief) ... [Et Al.]. Unit 14.7. PMID 23045003 DOI: 10.1002/0471140856.Tx1407S37 |
0.736 |
|
| 2008 |
Smith AR, Visioli F, Frei B, Hagen TM. Lipoic acid significantly restores, in rats, the age-related decline in vasomotion. British Journal of Pharmacology. 153: 1615-22. PMID 18297110 DOI: 10.1038/bjp.2008.28 |
0.332 |
|
| 2008 |
Dixon BM, Heath SH, Kim R, Suh JH, Hagen TM. Assessment of endoplasmic reticulum glutathione redox status is confounded by extensive ex vivo oxidation. Antioxidants & Redox Signaling. 10: 963-72. PMID 18205546 DOI: 10.1089/Ars.2007.1869 |
0.368 |
|
| 2007 |
Pehar M, Vargas MR, Robinson KM, Cassina P, Díaz-Amarilla PJ, Hagen TM, Radi R, Barbeito L, Beckman JS. Mitochondrial superoxide production and nuclear factor erythroid 2-related factor 2 activation in p75 neurotrophin receptor-induced motor neuron apoptosis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7777-85. PMID 17634371 DOI: 10.1523/Jneurosci.0823-07.2007 |
0.31 |
|
| 2006 |
Robinson KM, Janes MS, Pehar M, Monette JS, Ross MF, Hagen TM, Murphy MP, Beckman JS. Selective fluorescent imaging of superoxide in vivo using ethidium-based probes. Proceedings of the National Academy of Sciences of the United States of America. 103: 15038-43. PMID 17015830 DOI: 10.1073/Pnas.0601945103 |
0.728 |
|
| 2006 |
Smith AR, Visioli F, Frei B, Hagen TM. Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A. Aging Cell. 5: 391-400. PMID 16930126 DOI: 10.1111/J.1474-9726.2006.00232.X |
0.301 |
|
| 2005 |
Judge S, Jang YM, Smith A, Selman C, Phillips T, Speakman JR, Hagen T, Leeuwenburgh C. Exercise by lifelong voluntary wheel running reduces subsarcolemmal and interfibrillar mitochondrial hydrogen peroxide production in the heart American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 289. PMID 16051717 DOI: 10.1152/Ajpregu.00396.2005 |
0.444 |
|
| 2005 |
Suh JH, Moreau R, Heath SH, Hagen TM. Dietary supplementation with (R)-alpha-lipoic acid reverses the age-related accumulation of iron and depletion of antioxidants in the rat cerebral cortex. Redox Report : Communications in Free Radical Research. 10: 52-60. PMID 15829111 DOI: 10.1179/135100005X21624 |
0.372 |
|
| 2005 |
Liu H, Harrell LE, Shenvi S, Hagen T, Liu RM. Gender differences in glutathione metabolism in Alzheimer's disease. Journal of Neuroscience Research. 79: 861-7. PMID 15693022 DOI: 10.1002/Jnr.20424 |
0.726 |
|
| 2005 |
Judge S, Young MJ, Smith A, Hagen T, Leeuwenburgh C. Age-associated increases in oxidative stress and antioxidant enzyme activities in cardiac interfibrillar mitochondria: Implications for the mitochondrial theory of aging Faseb Journal. 19: 419-421. PMID 15642720 DOI: 10.1096/Fj.04-2622Fje |
0.364 |
|
| 2005 |
Moreau R, Nguyen BT, Doneanu CE, Hagen TM. Reversal by aminoguanidine of the age-related increase in glycoxidation and lipoxidation in the cardiovascular system of Fischer 344 rats. Biochemical Pharmacology. 69: 29-40. PMID 15588711 DOI: 10.1016/J.Bcp.2004.09.006 |
0.468 |
|
| 2004 |
Moreau R, Heath SH, Doneanu CE, Harris RA, Hagen TM. Age-related compensatory activation of pyruvate dehydrogenase complex in rat heart. Biochemical and Biophysical Research Communications. 325: 48-58. PMID 15522199 DOI: 10.1016/J.Bbrc.2004.10.011 |
0.45 |
|
| 2004 |
Liu H, Wang H, Shenvi S, Hagen TM, Liu RM. Glutathione metabolism during aging and in Alzheimer disease. Annals of the New York Academy of Sciences. 1019: 346-9. PMID 15247041 DOI: 10.1196/Annals.1297.059 |
0.752 |
|
| 2004 |
Smith AR, Shenvi SV, Widlansky M, Suh JH, Hagen TM. Lipoic acid as a potential therapy for chronic diseases associated with oxidative stress. Current Medicinal Chemistry. 11: 1135-46. PMID 15134511 DOI: 10.2174/0929867043365387 |
0.732 |
|
| 2004 |
Suh JH, Shenvi SV, Dixon BM, Liu H, Jaiswal AK, Liu RM, Hagen TM. Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid. Proceedings of the National Academy of Sciences of the United States of America. 101: 3381-6. PMID 14985508 DOI: 10.1073/Pnas.0400282101 |
0.775 |
|
| 2004 |
Suh JH, Wang H, Liu RM, Liu J, Hagen TM. (R)-alpha-lipoic acid reverses the age-related loss in GSH redox status in post-mitotic tissues: evidence for increased cysteine requirement for GSH synthesis. Archives of Biochemistry and Biophysics. 423: 126-35. PMID 14871476 DOI: 10.1016/J.Abb.2003.12.020 |
0.346 |
|
| 2003 |
Moreau R, Heath SH, Doneanu CE, Lindsay JG, Hagen TM. Age-related increase in 4-hydroxynonenal adduction to rat heart alpha-ketoglutarate dehydrogenase does not cause loss of its catalytic activity. Antioxidants & Redox Signaling. 5: 517-27. PMID 14580306 DOI: 10.1089/152308603770310167 |
0.498 |
|
| 2003 |
Hagen TM. Oxidative stress, redox imbalance, and the aging process. Antioxidants & Redox Signaling. 5: 503-6. PMID 14580304 DOI: 10.1089/152308603770310149 |
0.346 |
|
| 2003 |
Suh JH, Heath SH, Hagen TM. Two subpopulations of mitochondria in the aging rat heart display heterogenous levels of oxidative stress. Free Radical Biology & Medicine. 35: 1064-72. PMID 14572609 DOI: 10.1016/S0891-5849(03)00468-4 |
0.415 |
|
| 2003 |
Ames BN, Liu J, Atamna H, Hagen TM. Delaying the mitochondrial decay of aging in the brain Clinical Neuroscience Research. 2: 331-338. DOI: 10.1016/S1566-2772(03)00010-0 |
0.496 |
|
| 2002 |
Hagen TM, Moreau R, Suh JH, Visioli F. Mitochondrial decay in the aging rat heart: evidence for improvement by dietary supplementation with acetyl-L-carnitine and/or lipoic acid. Annals of the New York Academy of Sciences. 959: 491-507. PMID 11976222 DOI: 10.1111/j.1749-6632.2002.tb02119.x |
0.407 |
|
| 2002 |
Liu J, Head E, Gharib AM, Yuan W, Ingersoll RT, Hagen TM, Cotman CW, Ames BN. Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid. Proceedings of the National Academy of Sciences of the United States of America. 99: 2356-61. PMID 11854529 DOI: 10.1073/Pnas.261709299 |
0.385 |
|
| 2002 |
Hagen TM, Liu J, Lykkesfeldt J, Wehr CM, Ingersoll RT, Vinarsky V, Bartholomew JC, Ames BN. Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proceedings of the National Academy of Sciences of the United States of America. 99: 1870-5. PMID 11854487 DOI: 10.1073/Pnas.261708898 |
0.376 |
|
| 2002 |
Dixon BM, Shenvi SV, Hagen TM. Dietary antioxidants and cardiovascular disease Advances in Cell Aging and Gerontology. 11: 349-376. DOI: 10.1016/S1566-3124(02)11037-6 |
0.709 |
|
| 2001 |
Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, Hagen TM. Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-α-lipoic acid Faseb Journal. 15: 700-706. PMID 11259388 DOI: 10.1096/Fj.00-0176Com |
0.453 |
|
| 2000 |
Hagen TM, Vinarsky V, Wehr CM, Ames BN. (R)-alpha-lipoic acid reverses the age-associated increase in susceptibility of hepatocytes to tert-butylhydroperoxide both in vitro and in vivo. Antioxidants & Redox Signaling. 2: 473-83. PMID 11229361 DOI: 10.1089/15230860050192251 |
0.311 |
|
| 2000 |
Liu J, Yeo HC, Overvik-Douki E, Hagen T, Doniger SJ, Chyu DW, Brooks GA, Ames BN, Chu DW. Chronically and acutely exercised rats: biomarkers of oxidative stress and endogenous antioxidants. Journal of Applied Physiology (Bethesda, Md. : 1985). 89: 21-8. PMID 10904031 DOI: 10.1152/Jappl.2000.89.1.21 |
0.348 |
|
| 1999 |
Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, Bartholomew JC, Ames ABN. (R)-α-Lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 411-418. PMID 29426256 DOI: 10.1096/fasebj.13.2.411 |
0.349 |
|
| 1999 |
Hagen TM, Ingersoll RT, Lykkesfeldt J, Liu J, Wehr CM, Vinarsky V, Bartholomew JC, Ames BN. (R)-α-Lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate Faseb Journal. 13: 411-418. PMID 9973329 |
0.356 |
|
| 1998 |
Hagen TM, Wehr CM, Ames BN. Mitochondrial decay in aging. Reversal through supplementation of acetyl-L-carnitine and N-tert-butyl-α-phenyl-nitrone Annals of the New York Academy of Sciences. 854: 214-223. PMID 9928432 DOI: 10.1111/J.1749-6632.1998.Tb09904.X |
0.358 |
|
| 1998 |
Hagen TM, Ingersoll RT, Wehr CM, Lykkesfeldt J, Vinarsky V, Bartholomew JC, Song MH, Ames BN. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity Proceedings of the National Academy of Sciences of the United States of America. 95: 9562-9566. PMID 9689120 DOI: 10.1073/Pnas.95.16.9562 |
0.368 |
|
| 1997 |
Hagen TM, Yowe DL, Bartholomew JC, Wehr CM, Do KL, Park JY, Ames BN. Mitochondrial decay in hepatocytes from old rats: Membrane potential declines, heterogeneity and oxidants increase Proceedings of the National Academy of Sciences of the United States of America. 94: 3064-3069. PMID 9096346 DOI: 10.1073/Pnas.94.7.3064 |
0.372 |
|
| 1994 |
Shigenaga MK, Hagen TM, Ames BN. Oxidative damage and mitochondrial decay in aging Proceedings of the National Academy of Sciences of the United States of America. 91: 10771-10778. PMID 7971961 DOI: 10.1073/Pnas.91.23.10771 |
0.468 |
|
| 1993 |
Ames BN, Shigenaga MK, Hagen TM. Oxidants, antioxidants, and the degenerative diseases of aging Proceedings of the National Academy of Sciences of the United States of America. 90: 7915-7922. PMID 8367443 DOI: 10.1073/Pnas.90.17.7915 |
0.37 |
|
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