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Wilfred A. van der Donk - Publications

Affiliations: 
Chemistry University of Illinois, Urbana-Champaign, Urbana-Champaign, IL 
Area:
organic chemistry and chemical biology
Website:
http://www.chemistry.illinois.edu/faculty/Wilfred_van_der_Donk.html
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268 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Eslami SM, van der Donk WA. Proteases Involved in Leader Peptide Removal during RiPP Biosynthesis. Acs Bio & Med Chem Au. 4: 20-36. PMID 38404746 DOI: 10.1021/acsbiomedchemau.3c00059  0.366
2023 Yu Y, van der Donk WA. PEARL-catalyzed peptide bond formation after chain reversal during the biosynthesis of non-ribosomal peptides. Biorxiv : the Preprint Server For Biology. PMID 38187666 DOI: 10.1101/2023.12.23.573212  0.41
2023 Wu C, Lower BA, Moreira R, Dorantes D, Le T, Giurgiu C, Shi Y, van der Donk WA. Investigation into the mechanism of action of the antimicrobial peptide epilancin 15X. Frontiers in Microbiology. 14: 1247222. PMID 38029153 DOI: 10.3389/fmicb.2023.1247222  0.495
2023 Nguyen DT, Zhu L, Mitchell DA, van der Donk WA. Discovery of biaryl macrocyclic peptides with C-terminal β-amino-α-keto acid groups. Biorxiv : the Preprint Server For Biology. PMID 37965205 DOI: 10.1101/2023.10.30.564719  0.388
2023 Zheng Y, Xu X, Fu X, Zhou X, Dou C, Yu Y, Yan W, Yang J, Xiao M, van der Donk WA, Zhu X, Cheng W. Structures of the holoenzyme TglHI required for 3-thiaglutamate biosynthesis. Structure (London, England : 1993). PMID 37652001 DOI: 10.1016/j.str.2023.08.004  0.316
2023 Mi X, Desormeaux EK, Le TT, van der Donk WA, Shukla D. Sequence controlled secondary structure is important for the site-selectivity of lanthipeptide cyclization. Chemical Science. 14: 6904-6914. PMID 37389248 DOI: 10.1039/d2sc06546k  0.312
2023 Ayikpoe RS, Zhu L, Chen JY, Ting CP, van der Donk WA. Macrocyclization and Backbone Rearrangement During RiPP Biosynthesis by a SAM-Dependent Domain-of-Unknown-Function 692. Acs Central Science. 9: 1008-1018. PMID 37252350 DOI: 10.1021/acscentsci.3c00160  0.303
2023 Bown L, Hirota R, Goettge MN, Cui J, Krist DT, Zhu L, Giurgiu C, van der Donk WA, Ju KS, Metcalf WW. A Novel Pathway for Biosynthesis of the Herbicidal Phosphonate Natural Product Phosphonothrixin Is Widespread in Actinobacteria. Journal of Bacteriology. e0048522. PMID 37074199 DOI: 10.1128/jb.00485-22  0.572
2023 Lee H, Wu C, Desormeaux EK, Sarksian R, van der Donk WA. Improved production of class I lanthipeptides in . Chemical Science. 14: 2537-2546. PMID 36908960 DOI: 10.1039/d2sc06597e  0.405
2023 Mazo N, Rahman IR, Navo CD, Peregrina JM, Busto JH, van der Donk WA, Jiménez-Osés G. Synthesis of Fluorescent Lanthipeptide Cytolysin S Analogues by Late-Stage Sulfamidate Ring Opening. Organic Letters. PMID 36849130 DOI: 10.1021/acs.orglett.3c00122  0.327
2023 Ayikpoe RS, Zhu L, Chen JY, Ting CP, van der Donk WA. A remarkable transformation catalyzed by a domain-of-unknown-function 692 during the biosynthesis of a new RiPP natural product. Biorxiv : the Preprint Server For Biology. PMID 36798408 DOI: 10.1101/2023.02.06.527370  0.33
2023 Ongpipattanakul C, Liu S, Luo Y, Nair SK, van der Donk WA. The mechanism of thia-Michael addition catalyzed by LanC enzymes. Proceedings of the National Academy of Sciences of the United States of America. 120: e2217523120. PMID 36634136 DOI: 10.1073/pnas.2217523120  0.353
2022 Ayikpoe RS, Shi C, Battiste AJ, Eslami SM, Ramesh S, Simon MA, Bothwell IR, Lee H, Rice AJ, Ren H, Tian Q, Harris LA, Sarksian R, Zhu L, Frerk AM, ... ... van der Donk WA, et al. A scalable platform to discover antimicrobials of ribosomal origin. Nature Communications. 13: 6135. PMID 36253467 DOI: 10.1038/s41467-022-33890-w  0.395
2022 Pei ZF, Zhu L, Sarksian R, van der Donk WA, Nair SK. Class V Lanthipeptide Cyclase Directs the Biosynthesis of a Stapled Peptide Natural Product. Journal of the American Chemical Society. 144: 17549-17557. PMID 36107785 DOI: 10.1021/jacs.2c06808  0.36
2022 Liang H, Lopez IJ, Sánchez-Hidalgo M, Genilloud O, van der Donk WA. Mechanistic Studies on Dehydration in Class V Lanthipeptides. Acs Chemical Biology. 17: 2519-2527. PMID 36044589 DOI: 10.1021/acschembio.2c00458  0.37
2022 Sarksian R, van der Donk WA. Divergent Evolution of Lanthipeptide Stereochemistry. Acs Chemical Biology. PMID 36001880 DOI: 10.1021/acschembio.2c00492  0.371
2022 Yu Y, van der Donk WA. Biosynthesis of 3-thia-α-amino acids on a carrier peptide. Proceedings of the National Academy of Sciences of the United States of America. 119: e2205285119. PMID 35787182 DOI: 10.1073/pnas.2205285119  0.399
2022 Nguyen DT, Le TT, Rice AJ, Hudson GA, van der Donk WA, Mitchell DA. Accessing Diverse Pyridine-Based Macrocyclic Peptides by a Two-Site Recognition Pathway. Journal of the American Chemical Society. PMID 35713415 DOI: 10.1021/jacs.2c02824  0.394
2022 Daniels PN, van der Donk WA. Substrate Specificity of the Flavoenzyme BhaC That Converts a C-Terminal Trp to a Hydroxyquinone. Biochemistry. PMID 35613706 DOI: 10.1021/acs.biochem.2c00206  0.402
2022 McLaughlin MI, Yu Y, van der Donk WA. Substrate Recognition by the Peptidyl-()-2-mercaptoglycine Synthase TglHI during 3-Thiaglutamate Biosynthesis. Acs Chemical Biology. PMID 35362960 DOI: 10.1021/acschembio.2c00087  0.355
2022 Sarksian R, Hegemann JD, Simon MA, Acedo JZ, van der Donk WA. Unexpected Methyllanthionine Stereochemistry in the Morphogenetic Lanthipeptide SapT. Journal of the American Chemical Society. 144: 6373-6382. PMID 35352944 DOI: 10.1021/jacs.2c00517  0.362
2022 Lee H, van der Donk WA. Macrocyclization and Backbone Modification in RiPP Biosynthesis. Annual Review of Biochemistry. PMID 35303785 DOI: 10.1146/annurev-biochem-032620-104956  0.349
2022 Lundahl MN, Sarksian R, Yang H, Jodts RJ, Pagnier A, Smith DF, Mosquera MA, van der Donk WA, Hoffman BM, Broderick WE, Broderick JB. l-methionine Adenosylation: Radical Intermediates and the Catalytic Competence of the 5'-Deoxyadenosyl Radical. Journal of the American Chemical Society. PMID 35258967 DOI: 10.1021/jacs.1c13706  0.65
2021 Daniels PN, Lee H, Splain RA, Ting CP, Zhu L, Zhao X, Moore BS, van der Donk WA. A biosynthetic pathway to aromatic amines that uses glycyl-tRNA as nitrogen donor. Nature Chemistry. PMID 34725492 DOI: 10.1038/s41557-021-00802-2  0.847
2021 Le T, Jeanne Dit Fouque K, Santos-Fernandez M, Navo CD, Jiménez-Osés G, Sarksian R, Fernandez-Lima FA, van der Donk WA. Substrate Sequence Controls Regioselectivity of Lanthionine Formation by ProcM. Journal of the American Chemical Society. 143: 18733-18743. PMID 34724611 DOI: 10.1021/jacs.1c09370  0.336
2021 Ayikpoe RS, van der Donk WA. Peptide backbone modifications in lanthipeptides. Methods in Enzymology. 656: 573-621. PMID 34325799 DOI: 10.1016/bs.mie.2021.04.012  0.38
2021 Fujinami D, Garcia de Gonzalo CV, Biswas S, Hao Y, Wang H, Garg N, Lukk T, Nair SK, van der Donk WA. Structural and mechanistic investigations of protein S-glycosyltransferases. Cell Chemical Biology. PMID 34283964 DOI: 10.1016/j.chembiol.2021.06.009  0.553
2021 Bothwell IR, Caetano T, Sarksian R, Mendo S, van der Donk WA. Structural Analysis of Class I Lanthipeptides from NL19 Reveals an Unusual Ring Pattern. Acs Chemical Biology. PMID 34085816 DOI: 10.1021/acschembio.1c00106  0.384
2021 Lai KY, Galan SRG, Zeng Y, Zhou TH, He C, Raj R, Riedl J, Liu S, Chooi KP, Garg N, Zeng M, Jones LH, Hutchings GJ, Mohammed S, Nair SK, ... ... van der Donk WA, et al. LanCLs add glutathione to dehydroamino acids generated at phosphorylated sites in the proteome. Cell. PMID 33932340 DOI: 10.1016/j.cell.2021.04.001  0.801
2020 Bobeica SC, Zhu L, Acedo JZ, Tang W, van der Donk WA. Structural determinants of macrocyclization in substrate-controlled lanthipeptide biosynthetic pathways. Chemical Science. 11: 12854-12870. PMID 34094481 DOI: 10.1039/d0sc01651a  0.327
2020 Walker MC, Eslami SM, Hetrick KJ, Ackenhusen SE, Mitchell DA, van der Donk WA. Precursor peptide-targeted mining of more than one hundred thousand genomes expands the lanthipeptide natural product family. Bmc Genomics. 21: 387. PMID 32493223 DOI: 10.1186/S12864-020-06785-7  0.534
2020 Ren H, Shi C, Bothwell IR, van der Donk WA, Zhao H. Discovery and Characterization of a Class IV Lanthipeptide with a Non-overlapping Ring Pattern. Acs Chemical Biology. PMID 32356655 DOI: 10.1021/Acschembio.0C00267  0.425
2020 Rahman IR, Acedo JZ, Liu XR, Zhu L, Arrington J, Gross ML, van der Donk WA. Substrate Recognition by the Class II Lanthipeptide Synthetase HalM2. Acs Chemical Biology. PMID 32293871 DOI: 10.1021/Acschembio.0C00127  0.394
2019 Zhang Z, van der Donk WA. Non-ribosomal Peptide Extension by a Peptide Amino-acyl tRNA Ligase. Journal of the American Chemical Society. PMID 31751505 DOI: 10.1021/jacs.9b07111  0.419
2019 Acedo JZ, Bothwell IR, An L, Trouth A, Frazier C, van der Donk WA. O-Methyltransferase-mediated Incorporation of a β-Amino Acid in Lanthipeptides. Journal of the American Chemical Society. PMID 31568727 DOI: 10.1021/jacs.9b07396  0.375
2019 Huo L, Zhao X, Acedo JZ, Estrada P, Nair SK, van der Donk WA. Characterization of a dehydratase and methyltransferase in the biosynthesis of a ribosomally-synthesized and post-translationally modified peptide in Lachnospiraceae. Chembiochem : a European Journal of Chemical Biology. PMID 31532570 DOI: 10.1002/Cbic.201900483  0.557
2019 Bothwell IR, Cogan DP, Kim T, Reinhardt CJ, van der Donk WA, Nair SK. Characterization of glutamyl-tRNA-dependent dehydratases using nonreactive substrate mimics. Proceedings of the National Academy of Sciences of the United States of America. PMID 31409709 DOI: 10.1073/pnas.1905240116  0.395
2019 Ting CP, Funk MA, Halaby SL, Zhang Z, Gonen T, van der Donk WA. Use of a scaffold peptide in the biosynthesis of amino acid-derived natural products. Science (New York, N.Y.). 365: 280-284. PMID 31320540 DOI: 10.1126/Science.Aau6232  0.654
2019 Hegemann JD, Shi L, Gross ML, van der Donk WA. Mechanistic Studies of the Kinase Domains of Class IV Lanthipeptide Synthetases. Acs Chemical Biology. PMID 31243957 DOI: 10.1021/Acschembio.9B00323  0.313
2019 Hegemann JD, Bobeica S, Walker M, Bothwell IR, van der Donk WA. Assessing the Flexibility of the Prochlorosin 2.8 Scaffold for Bioengineering Applications. Acs Synthetic Biology. PMID 31042373 DOI: 10.1021/acssynbio.9b00080  0.547
2019 Bobeica SC, Dong S, Huo L, Mazo N, McLaughlin MIH, Jiménez-Osés G, Nair SK, van der Donk WA. Insights into AMS/PCAT transporters from biochemical and structural characterization of a double Glycine motif protease. Elife. 8. PMID 30638446 DOI: 10.7554/Elife.42305  0.56
2019 Bougioukou DJ, Ting CP, Peck SC, Mukherjee S, van der Donk WA. Use of the dehydrophos biosynthetic enzymes to prepare antimicrobial analogs of alaphosphin. Organic & Biomolecular Chemistry. PMID 30608108 DOI: 10.1039/C8Ob02860E  0.817
2018 Tang W, Bobeica SC, Wang L, van der Donk WA. CylA is a sequence-specific protease involved in toxin biosynthesis. Journal of Industrial Microbiology & Biotechnology. PMID 30484123 DOI: 10.1007/s10295-018-2110-9  0.36
2018 Wang KA, Ng TL, Wang P, Huang Z, Balskus EP, van der Donk WA. Glutamic acid is a carrier for hydrazine during the biosyntheses of fosfazinomycin and kinamycin. Nature Communications. 9: 3687. PMID 30206228 DOI: 10.1038/S41467-018-06083-7  0.689
2018 Si T, Tian Q, Min Y, Zhang L, Sweedler JV, van der Donk WA, Zhao H. Rapid structure-activity screening of lanthipeptide analogs via in-colony removal of leader peptides in Escherichia coli. Journal of the American Chemical Society. PMID 30183279 DOI: 10.1021/Jacs.8B05544  0.695
2018 Ren H, Biswas S, Ho S, van der Donk WA, Zhao H. Rapid Discovery of Glycocins through Pathway Refactoring in Escherichia coli. Acs Chemical Biology. PMID 30183259 DOI: 10.1021/Acschembio.8B00599  0.395
2018 An L, Cogan DP, Navo CD, Jiménez-Osés G, Nair SK, van der Donk WA. Substrate-assisted enzymatic formation of lysinoalanine in duramycin. Nature Chemical Biology. PMID 30177849 DOI: 10.1038/s41589-018-0122-4  0.309
2018 Hegemann JD, Schwalen CJ, Mitchell DA, van der Donk WA. Elucidation of the roles of conserved residues in the biosynthesis of the lasso peptide paeninodin. Chemical Communications (Cambridge, England). PMID 30046789 DOI: 10.1039/C8Cc04411B  0.351
2018 Dutta D, Lai KY, Reyes-Ordoñez A, Chen J, van der Donk WA. Lanthionine synthetase C-like protein 2 (LanCL2) is Important for Adipogenic Differentiation. Journal of Lipid Research. PMID 29880530 DOI: 10.1194/jlr.M085274  0.779
2018 Hetrick KJ, Walker MC, van der Donk WA. Development and Application of Yeast and Phage Display of Diverse Lanthipeptides. Acs Central Science. 4: 458-467. PMID 29721528 DOI: 10.1021/acscentsci.7b00581  0.516
2018 Hegemann JD, van der Donk WA. Investigation of Substrate Recognition and Biosynthesis in Class IV Lanthipeptide Systems. Journal of the American Chemical Society. PMID 29633842 DOI: 10.1021/jacs.8b01323  0.351
2018 Yang X, Lennard KR, He C, Walker MC, Ball AT, Doigneaux C, Tavassoli A, van der Donk WA. A lanthipeptide library used to identify a protein-protein interaction inhibitor. Nature Chemical Biology. PMID 29507389 DOI: 10.1038/S41589-018-0008-5  0.571
2018 Kakkar N, Perez JG, Liu WR, Jewett MC, van der Donk WA. Incorporation of non-proteinogenic amino acids in class I and II lanti-biotics. Acs Chemical Biology. PMID 29439566 DOI: 10.1021/Acschembio.7B01024  0.326
2018 Ulrich EC, Bougioukou DJ, van der Donk WA. Investigation of Amide Bond Formation during Dehydrophos Biosynthesis. Acs Chemical Biology. PMID 29303545 DOI: 10.1021/acschembio.7b00949  0.814
2017 Born DA, Ulrich EC, Ju KS, Peck SC, van der Donk WA, Drennan CL. Structural basis for methylphosphonate biosynthesis. Science (New York, N.Y.). 358: 1336-1339. PMID 29217579 DOI: 10.1126/Science.Aao3435  0.7
2017 Cogan DP, Hudson GA, Zhang Z, Pogorelov TV, van der Donk WA, Mitchell DA, Nair SK. Structural insights into enzymatic [4+2] aza-cycloaddition in thiopeptide antibiotic biosynthesis. Proceedings of the National Academy of Sciences of the United States of America. PMID 29158402 DOI: 10.1073/Pnas.1716035114  0.36
2017 Biswas S, Garcia De Gonzalo CV, Repka LM, van der Donk WA. Structure-Activity Relationships of the S-linked Glycocin Sublancin. Acs Chemical Biology. PMID 29112373 DOI: 10.1021/acschembio.7b00819  0.332
2017 Burkhart BJ, Kakkar N, Hudson GA, van der Donk WA, Mitchell DA. Chimeric Leader Peptides for the Generation of Non-Natural Hybrid RiPP Products. Acs Central Science. 3: 629-638. PMID 28691075 DOI: 10.1021/Acscentsci.7B00141  0.357
2017 Funk MA, van der Donk WA. Ribosomal Natural Products, Tailored To Fit. Accounts of Chemical Research. PMID 28682627 DOI: 10.1021/Acs.Accounts.7B00175  0.643
2017 Cubillos-Ruiz A, Berta-Thompson JW, Becker JW, van der Donk WA, Chisholm SW. Evolutionary radiation of lanthipeptides in marine cyanobacteria. Proceedings of the National Academy of Sciences of the United States of America. PMID 28630351 DOI: 10.1073/Pnas.1700990114  0.345
2017 Mahanta N, Zhang Z, Hudson GA, van der Donk WA, Mitchell DA. Reconstitution and substrate specificity of the radical SAM thiazole C-methyltransferase in thiomuracin biosynthesis. Journal of the American Chemical Society. PMID 28301141 DOI: 10.1021/Jacs.7B00693  0.339
2017 Repka LM, Chekan JR, Nair SK, van der Donk WA. Mechanistic Understanding of Lanthipeptide Biosynthetic Enzymes. Chemical Reviews. PMID 28135077 DOI: 10.1021/acs.chemrev.6b00591  0.388
2017 He C, Zeng M, Dutta D, Koh TH, Chen J, van der Donk WA. LanCL proteins are not Involved in Lanthionine Synthesis in Mammals. Scientific Reports. 7: 40980. PMID 28106097 DOI: 10.1038/Srep40980  0.539
2017 Peck SC, Wang C, Dassama LM, Zhang B, Guo Y, Rajakovich LJ, Bollinger JM, Krebs C, van der Donk WA. O-H Activation by an Unexpected Ferryl Intermediate during Catalysis by 2-Hydroxyethylphosphonate Dioxygenase. Journal of the American Chemical Society. 139: 2045-2052. PMID 28092705 DOI: 10.1021/Jacs.6B12147  0.689
2016 Huang Z, Wang KA, van der Donk WA. New Insights into the Biosynthesis of Fosfazinomycin. Chemical Science. 7: 5219-5223. PMID 28070267 DOI: 10.1039/C6Sc01389A  0.578
2016 Ortega MA, Cogan DP, Mukherjee S, Garg N, Li B, Thibodeaux GN, Maffioli S, Donadio S, Sosio M, Escano J, Smith L, Nair SK, van der Donk WA. Two flavoenzymes catalyze the post-translational generation of 5-chlorotryptophan and 2-aminovinyl-cysteine during NAI-107 biosynthesis. Acs Chemical Biology. PMID 28032983 DOI: 10.1021/Acschembio.6B01031  0.845
2016 Mukherjee S, Huo L, Thibodeaux GN, van der Donk WA. Synthesis and Bioactivity of Diastereomers of the Virulence Lanthipeptide Cytolysin. Organic Letters. 18: 6188-6191. PMID 27934350 DOI: 10.1021/Acs.Orglett.6B03246  0.465
2016 Clark KM, Tian S, van der Donk WA, Lu Y. Probing the role of the backbone carbonyl interaction with the CuA center in azurin by replacing the peptide bond with an ester linkage. Chemical Communications (Cambridge, England). PMID 27918029 DOI: 10.1039/C6Cc07274G  0.541
2016 Huo L, Ökesli A, Zhao M, van der Donk WA. Insights into the biosynthesis of duramycin. Applied and Environmental Microbiology. PMID 27864176 DOI: 10.1128/Aem.02698-16  0.836
2016 Peck SC, van der Donk WA. Go it alone: four-electron oxidations by mononuclear non-heme iron enzymes. Journal of Biological Inorganic Chemistry : Jbic : a Publication of the Society of Biological Inorganic Chemistry. PMID 27783267 DOI: 10.1007/S00775-016-1399-Y  0.597
2016 Zhang Z, Hudson GA, Mahanta N, Tietz JI, van der Donk WA, Mitchell DA. Biosynthetic timing and substrate specificity for the thiopeptide thiomuracin. Journal of the American Chemical Society. PMID 27700071 DOI: 10.1021/Jacs.6B08987  0.348
2016 Tang W, Thibodeaux GN, van der Donk WA. The Enterococcal Cytolysin Synthetase Coevolves with Substrate for Stereoselective Lanthionine Synthesis. Acs Chemical Biology. PMID 27348535 DOI: 10.1021/Acschembio.6B00397  0.403
2016 Garg N, Goto Y, Chen T, van der Donk WA. Characterization of the stereochemical configuration of lanthionines formed by the lanthipeptide synthetase GeoM. Biopolymers. PMID 27178086 DOI: 10.1002/Bip.22876  0.505
2016 Thibodeaux CJ, Wagoner J, Yu Y, van der Donk WA. The Leader Peptide Establishes Dehydration Order, Promotes Efficiency, and Ensures Fidelity During Lacticin 481 Biosynthesis. Journal of the American Chemical Society. PMID 27123925 DOI: 10.1021/Jacs.6B00163  0.746
2016 Huo L, van der Donk WA. Discovery and characterization of bicereucin, an unusual D-amino acid-containing mixed two-component lantibiotic. Journal of the American Chemical Society. PMID 27074593 DOI: 10.1021/Jacs.6B02513  0.58
2016 Zhao X, van der Donk WA. Structural Characterization and Bioactivity Analysis of the Two-Component Lantibiotic Flv System from a Ruminant Bacterium. Cell Chemical Biology. 23: 246-256. PMID 27028884 DOI: 10.1016/j.chembiol.2015.11.014  0.309
2016 Ortega MA, van der Donk WA. New Insights into the Biosynthetic Logic of Ribosomally Synthesized and Post-translationally Modified Peptide Natural Products. Cell Chemical Biology. 23: 31-44. PMID 26933734 DOI: 10.1016/J.Chembiol.2015.11.012  0.817
2016 Ortega MA, Hao Y, Walker MC, Donadio S, Sosio M, Nair SK, van der Donk WA. Structure and tRNA Specificity of MibB, a Lantibiotic Dehydratase from Actinobacteria Involved in NAI-107 Biosynthesis. Cell Chemical Biology. PMID 26877024 DOI: 10.1016/J.Chembiol.2015.11.017  0.82
2015 Tang W, Dong SH, Repka LM, He C, Nair SK, van der Donk WA. Applications of the class II lanthipeptide protease LicP for sequence-specific, traceless peptide bond cleavage. Chemical Science. 6: 6270-6279. PMID 30090246 DOI: 10.1039/C5Sc02329G  0.586
2015 Hudson GA, Zhang Z, Tietz JI, Mitchell DA, van der Donk WA. In vitro biosynthesis of the core scaffold of the thiopeptide thiomuracin. Journal of the American Chemical Society. PMID 26675417 DOI: 10.1021/Jacs.5B10194  0.371
2015 Yang X, van der Donk WA. Post-translational Introduction of d-Alanine into Ribosomally Synthesized Peptides by the Dehydroalanine Reductase NpnJ. Journal of the American Chemical Society. PMID 26361061 DOI: 10.1021/jacs.5b05207  0.345
2015 Ju KS, Gao J, Doroghazi JR, Wang KA, Thibodeaux CJ, Li S, Metzger E, Fudala J, Su J, Zhang JK, Lee J, Cioni JP, Evans BS, Hirota R, Labeda DP, ... van der Donk WA, et al. Discovery of phosphonic acid natural products by mining the genomes of 10,000 actinomycetes. Proceedings of the National Academy of Sciences of the United States of America. PMID 26324907 DOI: 10.1073/Pnas.1500873112  0.769
2015 Walker MC, van der Donk WA. The many roles of glutamate in metabolism. Journal of Industrial Microbiology & Biotechnology. PMID 26323613 DOI: 10.1007/s10295-015-1665-y  0.425
2015 Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, ... ... van der Donk WA, et al. Minimum Information about a Biosynthetic Gene cluster. Nature Chemical Biology. 11: 625-31. PMID 26284661 DOI: 10.1038/Nchembio.1890  0.686
2015 Zhu H, Peck SC, Bonnot F, van der Donk WA, Klinman JP. Oxygen-18 Kinetic Isotope Effects of Nonheme Iron Enzymes HEPD and MPnS Support Iron(III) Superoxide as the Hydrogen Abstraction Species. Journal of the American Chemical Society. PMID 26267117 DOI: 10.1021/Jacs.5B03907  0.568
2015 Bindman NA, Bobeica SC, Liu WR, van der Donk WA. Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid. Journal of the American Chemical Society. 137: 6975-8. PMID 26006047 DOI: 10.1021/jacs.5b04681  0.83
2015 Zhang Q, Doroghazi JR, Zhao X, Walker MC, van der Donk WA. Expanded natural product diversity revealed by analysis of lanthipeptide-like gene clusters in actinobacteria. Applied and Environmental Microbiology. 81: 4339-50. PMID 25888176 DOI: 10.1128/AEM.00635-15  0.464
2015 Yang X, van der Donk WA. Michael-type cyclizations in lantibiotic biosynthesis are reversible. Acs Chemical Biology. 10: 1234-8. PMID 25723375 DOI: 10.1021/acschembio.5b00007  0.359
2015 Peck SC, Chekan JR, Ulrich EC, Nair SK, van der Donk WA. A common late-stage intermediate in catalysis by 2-hydroxyethyl-phosphonate dioxygenase and methylphosphonate synthase. Journal of the American Chemical Society. 137: 3217-20. PMID 25699631 DOI: 10.1021/Jacs.5B00282  0.598
2015 Huang Z, Wang KK, Lee J, van der Donk WA. Biosynthesis of fosfazinomycin is a convergent process. Chemical Science (Royal Society of Chemistry : 2010). 6: 1282-1287. PMID 25621145 DOI: 10.1039/C4Sc03095H  0.592
2015 Thibodeaux GN, McClerren AL, Ma Y, Gancayco MR, van der Donk WA. Synergistic binding of the leader and core peptides by the lantibiotic synthetase HalM2. Acs Chemical Biology. 10: 970-7. PMID 25619528 DOI: 10.1021/Cb5009876  0.317
2015 Tang W, Jiménez-Osés G, Houk KN, van der Donk WA. Substrate control in stereoselective lanthionine biosynthesis. Nature Chemistry. 7: 57-64. PMID 25515891 DOI: 10.1038/Nchem.2113  0.309
2015 Ortega MA, Hao Y, Zhang Q, Walker MC, van der Donk WA, Nair SK. Structure and mechanism of the tRNA-dependent lantibiotic dehydratase NisB. Nature. 517: 509-12. PMID 25363770 DOI: 10.1038/Nature13888  0.832
2015 Bindman NA, Bobeica SC, Liu WR, Van Der Donk WA. Facile Removal of Leader Peptides from Lanthipeptides by Incorporation of a Hydroxy Acid Journal of the American Chemical Society. 137: 6975-6978. DOI: 10.1021/jacs.5b04681  0.822
2014 van der Donk WA, Nair SK. Structure and mechanism of lanthipeptide biosynthetic enzymes. Current Opinion in Structural Biology. 29: 58-66. PMID 25460269 DOI: 10.1016/j.sbi.2014.09.006  0.411
2014 Thibodeaux CJ, Ha T, van der Donk WA. A price to pay for relaxed substrate specificity: a comparative kinetic analysis of the class II lanthipeptide synthetases ProcM and HalM2. Journal of the American Chemical Society. 136: 17513-29. PMID 25409537 DOI: 10.1021/Ja5089452  0.75
2014 Zhang Q, Yang X, Wang H, van der Donk WA. High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis. Acs Chemical Biology. 9: 2686-94. PMID 25244001 DOI: 10.1021/cb500622c  0.37
2014 Zhang Q, Ortega M, Shi Y, Wang H, Melby JO, Tang W, Mitchell DA, van der Donk WA. Structural investigation of ribosomally synthesized natural products by hypothetical structure enumeration and evaluation using tandem MS. Proceedings of the National Academy of Sciences of the United States of America. 111: 12031-6. PMID 25092299 DOI: 10.1073/Pnas.1406418111  0.8
2014 Huang Y, Reis ES, Knerr PJ, van der Donk WA, Ricklin D, Lambris JD. Conjugation to albumin-binding molecule tags as a strategy to improve both efficacy and pharmacokinetic properties of the complement inhibitor compstatin. Chemmedchem. 9: 2223-6. PMID 25056114 DOI: 10.1002/Cmdc.201402212  0.744
2014 Mukherjee S, van der Donk WA. Mechanistic studies on the substrate-tolerant lanthipeptide synthetase ProcM. Journal of the American Chemical Society. 136: 10450-9. PMID 24972336 DOI: 10.1021/ja504692v  0.402
2014 Ortega MA, Velásquez JE, Garg N, Zhang Q, Joyce RE, Nair SK, van der Donk WA. Substrate specificity of the lanthipeptide peptidase ElxP and the oxidoreductase ElxO. Acs Chemical Biology. 9: 1718-25. PMID 24866416 DOI: 10.1021/Cb5002526  0.831
2014 Clark KM, Yu Y, van der Donk WA, Blackburn N, Lu Y. Modulating the Copper-Sulfur Interaction in Type 1 Blue Copper Azurin by Replacing Cys112 with Nonproteinogenic Homocysteine. Inorganic Chemistry Frontiers. 1: 153-158. PMID 24707355 DOI: 10.1039/C3Qi00096F  0.513
2014 Hung JE, Fogle EJ, Garg N, Chekan JR, Nair SK, van der Donk WA. Chemical rescue and inhibition studies to determine the role of Arg301 in phosphite dehydrogenase. Plos One. 9: e87134. PMID 24498026 DOI: 10.1371/Journal.Pone.0087134  0.767
2014 Garcia De Gonzalo CV, Zhu L, Oman TJ, Van Der Donk WA. NMR structure of the S-linked glycopeptide sublancin 168 Acs Chemical Biology. 9: 796-801. PMID 24405370 DOI: 10.1021/cb4008106  0.761
2014 Gao J, Ju KS, Yu X, Velásquez JE, Mukherjee S, Lee J, Zhao C, Evans BS, Doroghazi JR, Metcalf WW, van der Donk WA. Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster. Angewandte Chemie (International Ed. in English). 53: 1334-7. PMID 24376039 DOI: 10.1002/Anie.201308363  0.689
2014 Agarwal V, Peck SC, Chen JH, Borisova SA, Chekan JR, van der Donk WA, Nair SK. Structure and function of phosphonoacetaldehyde dehydrogenase: the missing link in phosphonoacetate formation. Chemistry & Biology. 21: 125-35. PMID 24361046 DOI: 10.1016/J.Chembiol.2013.11.006  0.795
2014 Wang H, Oman TJ, Zhang R, Garcia De Gonzalo CV, Zhang Q, Van Der Donk WA. The glycosyltransferase involved in thurandacin biosynthesis catalyzes both O- and S-glycosylation Journal of the American Chemical Society. 136: 84-87. PMID 24325644 DOI: 10.1021/ja411159k  0.778
2014 Garg N, Oman TJ, Andrew Wang TS, De Gonzalo CVG, Walker S, Van Der Donk WA. Mode of action and structure-activity relationship studies of geobacillin i Journal of Antibiotics. 67: 133-136. PMID 24169799 DOI: 10.1038/Ja.2013.112  0.798
2014 Zhang Q, Yang X, Wang H, Van Der Donk WA. High divergence of the precursor peptides in combinatorial lanthipeptide biosynthesis Acs Chemical Biology. 9: 2686-2694. DOI: 10.1021/cb500622c  0.302
2014 Huang Y, Reis ES, Knerr PJ, Van Der Donk WA, Ricklin D, Lambris JD. Conjugation to albumin-binding molecule tags as a strategy to improve both efficacy and pharmacokinetic properties of the complement inhibitor compstatin Chemmedchem. 9: 2223-2226. DOI: 10.1002/cmdc.201402212  0.702
2014 Bindman NA, Van Der Donk WA. RiPPs: Ribosomally Synthesized and Posttranslationally Modified Peptides Natural Products: Discourse, Diversity, and Design. 195-217. DOI: 10.1002/9781118794623.ch11  0.819
2013 Yu Y, Zhang Q, Van Der Donk WA. Insights into the evolution of lanthipeptide biosynthesis Protein Science. 22: 1478-1489. PMID 24038659 DOI: 10.1002/pro.2358  0.362
2013 Peck SC, van der Donk WA. Phosphonate biosynthesis and catabolism: a treasure trove of unusual enzymology. Current Opinion in Chemical Biology. 17: 580-8. PMID 23870698 DOI: 10.1016/J.Cbpa.2013.06.018  0.629
2013 Bindman NA, Van Der Donk WA. A general method for fluorescent labeling of the N-termini of lanthipeptides and its application to visualize their cellular localization Journal of the American Chemical Society. 135: 10362-10371. PMID 23789944 DOI: 10.1021/ja4010706  0.783
2013 Bougioukou DJ, Mukherjee S, Van Der Donk WA. Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway Proceedings of the National Academy of Sciences of the United States of America. 110: 10952-10957. PMID 23776232 DOI: 10.1073/pnas.1303568110  0.805
2013 Yang X, Van Der Donk WA. Ribosomally synthesized and post-translationally modified peptide natural products: New insights into the role of leader and core peptides during biosynthesis Chemistry - a European Journal. 19: 7662-7677. PMID 23666908 DOI: 10.1002/chem.201300401  0.375
2013 Knerr PJ, Van Der Donk WA. Chemical synthesis of the lantibiotic lacticin 481 reveals the importance of lanthionine stereochemistry Journal of the American Chemical Society. 135: 7094-7097. PMID 23621626 DOI: 10.1021/ja4014024  0.783
2013 Garg N, Salazar-Ocampo LMA, Van Der Donk WA. In vitro activity of the nisin dehydratase NisB Proceedings of the National Academy of Sciences of the United States of America. 110: 7258-7263. PMID 23589847 DOI: 10.1073/Pnas.1222488110  0.559
2013 Peck SC, van der Donk WA. Biochemistry: Positive and radical. Nature. 496: 34-5. PMID 23552937 DOI: 10.1038/496034A  0.603
2013 Evans BS, Zhao C, Gao J, Evans CM, Ju KS, Doroghazi JR, van der Donk WA, Kelleher NL, Metcalf WW. Discovery of the antibiotic phosacetamycin via a new mass spectrometry-based method for phosphonic acid detection. Acs Chemical Biology. 8: 908-13. PMID 23474169 DOI: 10.1021/Cb400102T  0.547
2013 Tang W, Van Der Donk WA. The sequence of the enterococcal cytolysin imparts unusual lanthionine stereochemistry Nature Chemical Biology. 9: 157-159. PMID 23314913 DOI: 10.1038/nchembio.1162  0.328
2013 Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, ... ... van der Donk WA, et al. Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature. Natural Product Reports. 30: 108-60. PMID 23165928 DOI: 10.1039/C2Np20085F  0.663
2012 Peck SC, Kim SY, Evans BS, van der Donk WA. Stereochemistry of Hydride Transfer by Group III Alcohol Dehydrogenases Involved in Phosphonate Biosynthesis. Medchemcomm. 3: 967-970. PMID 25400901 DOI: 10.1039/C2Md20009K  0.562
2012 Thibodeaux CJ, Van Der Donk WA. Converging on a mechanism for choline degradation Proceedings of the National Academy of Sciences of the United States of America. 109: 21184-21185. PMID 23243142 DOI: 10.1073/Pnas.1219534110  0.709
2012 Zhang Q, Yu Y, Vélasquez JE, Van Der Donk WA. Evolution of lanthipeptide synthetases Proceedings of the National Academy of Sciences of the United States of America. 109: 18361-18366. PMID 23071302 DOI: 10.1073/pnas.1210393109  0.63
2012 Shi Y, Bueno A, Van Der Donk WA. Heterologous production of the lantibiotic Ala(0)actagardine in Escherichia coli Chemical Communications. 48: 10966-10968. PMID 23034674 DOI: 10.1039/C2Cc36336D  0.567
2012 Peck SC, Gao J, van der Donk WA. Discovery and biosynthesis of phosphonate and phosphinate natural products. Methods in Enzymology. 516: 101-23. PMID 23034226 DOI: 10.1016/B978-0-12-394291-3.00029-0  0.61
2012 Cooke HA, Peck SC, Evans BS, van der Donk WA. Mechanistic investigation of methylphosphonate synthase, a non-heme iron-dependent oxygenase. Journal of the American Chemical Society. 134: 15660-3. PMID 22957470 DOI: 10.1021/Ja306777W  0.703
2012 Metcalf WW, Griffin BM, Cicchillo RM, Gao J, Janga SC, Cooke HA, Circello BT, Evans BS, Martens-Habbena W, Stahl DA, van der Donk WA. Synthesis of methylphosphonic acid by marine microbes: a source for methane in the aerobic ocean. Science (New York, N.Y.). 337: 1104-7. PMID 22936780 DOI: 10.1126/Science.1219875  0.79
2012 Knerr PJ, Oman TJ, Garcia De Gonzalo CV, Lupoli TJ, Walker S, Van Der Donk WA. Non-proteinogenic amino acids in lacticin 481 analogues result in more potent inhibition of peptidoglycan transglycosylation Acs Chemical Biology. 7: 1791-1795. PMID 22920239 DOI: 10.1021/Cb300372B  0.814
2012 Zhang Q, Van Der Donk WA. Catalytic promiscuity of a bacterial α-N-methyltransferase Febs Letters. 586: 3391-3397. PMID 22841713 DOI: 10.1016/j.febslet.2012.07.050  0.311
2012 Wang H, Van Der Donk WA. Biosynthesis of the class III lantipeptide catenulipeptin Acs Chemical Biology. 7: 1529-1535. PMID 22725258 DOI: 10.1021/cb3002446  0.384
2012 Kim SY, Ju KS, Metcalf WW, Evans BS, Kuzuyama T, Van Der Donk WA. Different biosynthetic pathways to fosfomycin in Pseudomonas syringae and Streptomyces species Antimicrobial Agents and Chemotherapy. 56: 4175-4183. PMID 22615277 DOI: 10.1128/Aac.06478-11  0.559
2012 Tang W, Van Der Donk WA. Structural characterization of four prochlorosins: A novel class of lantipeptides produced by planktonic marine cyanobacteria Biochemistry. 51: 4271-4279. PMID 22574919 DOI: 10.1021/bi300255s  0.336
2012 Zou Y, Zhang H, Brunzelle JS, Johannes TW, Woodyer R, Hung JE, Nair N, Van Der Donk WA, Zhao H, Nair SK. Crystal structures of phosphite dehydrogenase provide insights into nicotinamide cofactor regeneration Biochemistry. 51: 4263-4270. PMID 22564171 DOI: 10.1021/Bi2016926  0.377
2012 Hung JE, Fogle EJ, Christman HD, Johannes TW, Zhao H, Metcalf WW, Van Der Donk WA. Investigation of the role of Arg301 identified in the X-ray structure of phosphite dehydrogenase Biochemistry. 51: 4254-4262. PMID 22564138 DOI: 10.1021/Bi201691W  0.812
2012 Knerr PJ, Van Der Donk WA. Chemical synthesis and biological activity of analogues of the lantibiotic epilancin 15X Journal of the American Chemical Society. 134: 7648-7651. PMID 22524291 DOI: 10.1021/ja302435y  0.779
2012 Oman TJ, Knerr PJ, Bindman NA, Velásquez JE, Van Der Donk WA. An engineered lantibiotic synthetase that does not require a leader peptide on its substrate Journal of the American Chemical Society. 134: 6952-6955. PMID 22480178 DOI: 10.1021/ja3017297  0.821
2012 Garg N, Tang W, Goto Y, Nair SK, Van Der Donk WA. Lantibiotics from Geobacillus thermodenitrificans Proceedings of the National Academy of Sciences of the United States of America. 109: 5241-5246. PMID 22431611 DOI: 10.1073/Pnas.1116815109  0.437
2012 Knerr PJ, Van Der Donk WA. Discovery, biosynthesis, and engineering of lantipeptides Annual Review of Biochemistry. 81: 479-505. PMID 22404629 DOI: 10.1146/annurev-biochem-060110-113521  0.757
2011 Agarwal V, Borisova SA, Metcalf WW, van der Donk WA, Nair SK. Structural and mechanistic insights into C-P bond hydrolysis by phosphonoacetate hydrolase. Chemistry & Biology. 18: 1230-40. PMID 22035792 DOI: 10.1016/J.Chembiol.2011.07.019  0.779
2011 Oman TJ, Lupoli TJ, Wang TSA, Kahne D, Walker S, Van Der Donk WA. Haloduracin α binds the peptidoglycan precursor lipid II with 2:1 stoichiometry Journal of the American Chemical Society. 133: 17544-17547. PMID 22003874 DOI: 10.1021/Ja206281K  0.764
2011 Wang H, Van Der Donk WA. Substrate selectivity of the sublancin S-glycosyltransferase Journal of the American Chemical Society. 133: 16394-16397. PMID 21910430 DOI: 10.1021/ja2075168  0.357
2011 Desieno MA, Van Der Donk WA, Zhao H. Characterization and application of the Fe(ii) and α-ketoglutarate dependent hydroxylase FrbJ Chemical Communications. 47: 10025-10027. PMID 21829824 DOI: 10.1039/C1Cc13597J  0.314
2011 Velásquez JE, Zhang X, Van Der Donk WA. Biosynthesis of the antimicrobial peptide epilancin 15X and its N-terminal lactate Chemistry and Biology. 18: 857-867. PMID 21802007 DOI: 10.1016/J.Chembiol.2011.05.007  0.616
2011 Ökesli A, Cooper LE, Fogle EJ, Van Der Donk WA. Nine post-translational modifications during the biosynthesis of cinnamycin Journal of the American Chemical Society. 133: 13753-13760. PMID 21770392 DOI: 10.1021/Ja205783F  0.833
2011 Peck SC, Cooke HA, Cicchillo RM, Malova P, Hammerschmidt F, Nair SK, van der Donk WA. Mechanism and substrate recognition of 2-hydroxyethylphosphonate dioxygenase. Biochemistry. 50: 6598-605. PMID 21711001 DOI: 10.1021/Bi200804R  0.803
2011 Borisova SA, Christman HD, Mourey Metcalf ME, Zulkepli NA, Zhang JK, Van Der Donk WA, Metcalf WW. Genetic and biochemical characterization of a pathway for the degradation of 2-aminoethylphosphonate in Sinorhizobium meliloti 1021 Journal of Biological Chemistry. 286: 22283-22290. PMID 21543322 DOI: 10.1074/Jbc.M111.237735  0.759
2011 Circello BT, Miller CG, Lee JH, Van Der Donk WA, Metcalf WW. The antibiotic dehydrophos is converted to a toxic pyruvate analog by peptide bond cleavage in Salmonella enterica Antimicrobial Agents and Chemotherapy. 55: 3357-3362. PMID 21537024 DOI: 10.1128/Aac.01483-10  0.688
2011 Knerr PJ, Tzekou A, Ricklin D, Qu H, Chen H, Van Der Donk WA, Lambris JD. Synthesis and activity of thioether-containing analogues of the complement inhibitor compstatin Acs Chemical Biology. 6: 753-760. PMID 21520911 DOI: 10.1021/Cb2000378  0.788
2011 Gut IM, Blanke SR, Van Der Donk WA. Mechanism of inhibition of bacillus anthracis spore outgrowth by the Lantibiotic Nisin Acs Chemical Biology. 6: 744-752. PMID 21517116 DOI: 10.1021/Cb1004178  0.497
2011 Whitteck JT, Malova P, Peck SC, Cicchillo RM, Hammerschmidt F, van der Donk WA. On the stereochemistry of 2-hydroxyethylphosphonate dioxygenase. Journal of the American Chemical Society. 133: 4236-9. PMID 21381767 DOI: 10.1021/Ja1113326  0.778
2011 Gut IM, Tamilselvam B, Prouty AM, Stojkovic B, Czeschin S, Van Der Donk WA, Blanke SR. Bacillus anthracis spore interactions with mammalian cells: Relationship between germination state and the outcome of in vitro Bmc Microbiology. 11. PMID 21356113 DOI: 10.1186/1471-2180-11-46  0.452
2011 Goto Y, Ökesli A, Van Der Donk WA. Mechanistic studies of Ser/Thr dehydration catalyzed by a member of the LanL lanthionine synthetase family Biochemistry. 50: 891-898. PMID 21229987 DOI: 10.1021/Bi101750R  0.789
2011 Oman TJ, Boettcher JM, Wang H, Okalibe XN, Van Der Donk WA. Sublancin is not a lantibiotic but an S-linked glycopeptide Nature Chemical Biology. 7: 78-80. PMID 21196935 DOI: 10.1038/Nchembio.509  0.75
2011 Shi Y, Yang X, Garg N, Van Der Donk WA. Production of lantipeptides in Escherichia coli Journal of the American Chemical Society. 133: 2338-2341. PMID 21114289 DOI: 10.1021/Ja109044R  0.674
2011 Velásquez JE, Van der Donk WA. Genome mining for ribosomally synthesized natural products Current Opinion in Chemical Biology. 15: 11-21. PMID 21095156 DOI: 10.1016/j.cbpa.2010.10.027  0.624
2010 Bindman N, Merkx R, Koehler R, Herrman N, Van Der Donk WA. Photochemical cleavage of leader peptides Chemical Communications. 46: 8935-8937. PMID 21046030 DOI: 10.1039/C0Cc02945A  0.826
2010 van der Donk WA, Krebs C, Bollinger JM. Substrate activation by iron superoxo intermediates. Current Opinion in Structural Biology. 20: 673-83. PMID 20951572 DOI: 10.1016/J.Sbi.2010.08.005  0.517
2010 Lee JH, Bae B, Kuemin M, Circello BT, Metcalf WW, Nair SK, Van Der Donk WA. Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis Proceedings of the National Academy of Sciences of the United States of America. 107: 17557-17562. PMID 20876132 DOI: 10.1073/Pnas.1006848107  0.818
2010 Kuemin M, Van Der Donk WA. Structure-activity relationships of the phosphonate antibiotic dehydrophos Chemical Communications. 46: 7694-7696. PMID 20871915 DOI: 10.1039/C0Cc02958K  0.79
2010 Clark KM, Yu Y, Marshall NM, Sieracki NA, Nilges MJ, Blackburn NJ, van der Donk WA, Lu Y. Transforming a blue copper into a red copper protein: engineering cysteine and homocysteine into the axial position of azurin using site-directed mutagenesis and expressed protein ligation. Journal of the American Chemical Society. 132: 10093-101. PMID 20608676 DOI: 10.1021/Ja102632P  0.517
2010 Li B, Sher D, Kelly L, Shi Y, Huang K, Knerr PJ, Joewono I, Rusch D, Chisholm SW, van der Donk WA. Catalytic promiscuity in the biosynthesis of cyclic peptide secondary metabolites in planktonic marine cyanobacteria. Proceedings of the National Academy of Sciences of the United States of America. 107: 10430-5. PMID 20479271 DOI: 10.1073/Pnas.0913677107  0.819
2010 Circello BT, Eliot AC, Lee JH, van der Donk WA, Metcalf WW. Molecular Cloning and Heterologous Expression of the Dehydrophos Biosynthetic Gene Cluster Chemistry and Biology. 17: 402-411. PMID 20416511 DOI: 10.1016/J.Chembiol.2010.03.007  0.591
2010 Goto Y, Li B, Claesen J, Shi Y, Bibb MJ, van der Donk WA. Discovery of unique lanthionine synthetases reveals new mechanistic and evolutionary insights. Plos Biology. 8: e1000339. PMID 20351769 DOI: 10.1371/Journal.Pbio.1000339  0.634
2010 Borisova SA, Circello BT, Zhang JK, van der Donk WA, Metcalf WW. Biosynthesis of Rhizocticins, Antifungal Phosphonate Oligopeptides Produced by Bacillus subtilis ATCC6633 Chemistry and Biology. 17: 28-37. PMID 20142038 DOI: 10.1016/J.Chembiol.2009.11.017  0.788
2010 Oman TJ, Van Der Donk WA. Follow the leader: The use of leader peptides to guide natural product biosynthesis Nature Chemical Biology. 6: 9-18. PMID 20016494 DOI: 10.1038/nchembio.286  0.782
2010 Cooper LE, Li B, van der Donk WA. Biosynthesis and mode of action of lantibiotics Comprehensive Natural Products Ii: Chemistry and Biology. 5: 217-256.  0.49
2009 Whitteck JT, Cicchillo RM, Van Der Donk WA. Hydroperoxylation by hydroxyethylphosphonate dioxygenase Journal of the American Chemical Society. 131: 16225-16232. PMID 19839620 DOI: 10.1021/ja906238r  0.795
2009 Oman TJ, Van Der Donk WA. Insights into the mode of action of the two-peptide lantibiotic haloduracin Acs Chemical Biology. 4: 865-874. PMID 19678697 DOI: 10.1021/cb900194x  0.782
2009 Lee MV, Ihnken LA, You YO, McClerren AL, van der Donk WA, Kelleher NL. Distributive and directional behavior of lantibiotic synthetases revealed by high-resolution tandem mass spectrometry. Journal of the American Chemical Society. 131: 12258-64. PMID 19663480 DOI: 10.1021/Ja9033507  0.809
2009 Levengood MR, Knerr PJ, Oman TJ, Van Der Donk WA. In vitro mutasynthesis of lantibiotic analogues containing nonproteinogenic amino acids Journal of the American Chemical Society. 131: 12024-12025. PMID 19655738 DOI: 10.1021/ja903239s  0.812
2009 Zhang X, van der Donk WA. Chapter 6 Using Expressed Protein Ligation to Probe the Substrate Specificity of Lantibiotic Synthetases Methods in Enzymology. 462: 117-134. PMID 19632472 DOI: 10.1016/S0076-6879(09)62006-1  0.415
2009 Clark KM, van der Donk WA, Lu Y. Chapter 5 Expressed Protein Ligation for Metalloprotein Design and Engineering Methods in Enzymology. 462: 97-115. PMID 19632471 DOI: 10.1016/S0076-6879(09)62005-X  0.54
2009 Cicchillo RM, Zhang H, Blodgett JAV, Whitteck JT, Li G, Nair SK, Van Der Donk WA, Metcalf WW. An unusual carbon-carbon bond cleavage reaction during phosphinothricin biosynthesis Nature. 459: 871-874. PMID 19516340 DOI: 10.1038/Nature07972  0.801
2009 Metcalf WW, Van Der Donk WA. Biosynthesis of phosphonic and phosphinic acid natural products Annual Review of Biochemistry. 78: 65-94. PMID 19489722 DOI: 10.1146/Annurev.Biochem.78.091707.100215  0.582
2009 Wecksler AT, Jacquot C, Van Der Donk WA, Holman TR. Mechanistic investigations of human reticulocyte 15- and platelet 12-lipoxygenases with arachidonic acid Biochemistry. 48: 6259-6267. PMID 19469483 DOI: 10.1021/Bi802332J  0.502
2009 Lee JH, Evans BS, Li G, Kelleher NL, van der Donk WA. In vitro characterization of a heterologously expressed nonribosomal Peptide synthetase involved in phosphinothricin tripeptide biosynthesis. Biochemistry. 48: 5054-6. PMID 19432442 DOI: 10.1021/Bi900164D  0.376
2009 Li B, Cooper LE, van der Donk WA. Chapter 21. In vitro studies of lantibiotic biosynthesis. Methods in Enzymology. 458: 533-58. PMID 19374997 DOI: 10.1016/S0076-6879(09)04821-6  0.683
2009 You YO, Levengood MR, Ihnken LA, Knowlton AK, van der Donk WA. Lacticin 481 synthetase as a general serine/threonine kinase. Acs Chemical Biology. 4: 379-85. PMID 19292452 DOI: 10.1021/Cb800309V  0.82
2009 Levengood MR, Kerwood CC, Chatterjee C, van der Donk WA. Investigation of the substrate specificity of lacticin 481 synthetase by using nonproteinogenic amino acids. Chembiochem : a European Journal of Chemical Biology. 10: 911-9. PMID 19222036 DOI: 10.1002/Cbic.200800752  0.833
2008 Barry AN, Clark KM, Otoikhian A, van der Donk WA, Blackburn NJ. Selenocysteine positional variants reveal contributions to copper binding from cysteine residues in domains 2 and 3 of human copper chaperone for superoxide dismutase. Biochemistry. 47: 13074-83. PMID 19007184 DOI: 10.1021/Bi801438G  0.528
2008 Jacquot C, McGinley CM, Plata E, Holman TR, van der Donk WA. Synthesis of 11-thialinoleic acid and 14-thialinoleic acid, inhibitors of soybean and human lipoxygenases. Organic & Biomolecular Chemistry. 6: 4242-52. PMID 18972057 DOI: 10.1039/B808003H  0.716
2008 Cooper LE, McClerren AL, Chary A, van der Donk WA. Structure-activity relationship studies of the two-component lantibiotic haloduracin. Chemistry & Biology. 15: 1035-45. PMID 18940665 DOI: 10.1016/J.Chembiol.2008.07.020  0.653
2008 Gut IM, Prouty AM, Ballard JD, van der Donk WA, Blanke SR. Inhibition of Bacillus anthracis spore outgrowth by nisin. Antimicrobial Agents and Chemotherapy. 52: 4281-8. PMID 18809941 DOI: 10.1128/Aac.00625-08  0.482
2008 Jacquot C, Peng S, van der Donk WA. Kinetic isotope effects in the oxidation of arachidonic acid by soybean lipoxygenase-1. Bioorganic & Medicinal Chemistry Letters. 18: 5959-62. PMID 18793849 DOI: 10.1016/J.Bmcl.2008.08.108  0.523
2008 Patton GC, Paul M, Cooper LE, Chatterjee C, van der Donk WA. The importance of the leader sequence for directing lanthionine formation in lacticin 481. Biochemistry. 47: 7342-51. PMID 18570437 DOI: 10.1021/Bi800277D  0.836
2008 Furgerson Ihnken LA, Chatterjee C, van der Donk WA. In vitro reconstitution and substrate specificity of a lantibiotic protease. Biochemistry. 47: 7352-63. PMID 18570436 DOI: 10.1021/Bi800278N  0.606
2008 Jacquot C, Wecksler AT, McGinley CM, Segraves EN, Holman TR, van der Donk WA. Isotope sensitive branching and kinetic isotope effects in the reaction of deuterated arachidonic acids with human 12- and 15-lipoxygenases. Biochemistry. 47: 7295-303. PMID 18547056 DOI: 10.1021/Bi800308Q  0.721
2008 Shao Z, Blodgett JA, Circello BT, Eliot AC, Woodyer R, Li G, van der Donk WA, Metcalf WW, Zhao H. Biosynthesis of 2-hydroxyethylphosphonate, an unexpected intermediate common to multiple phosphonate biosynthetic pathways. The Journal of Biological Chemistry. 283: 23161-8. PMID 18544530 DOI: 10.1074/Jbc.M801788200  0.64
2008 Levengood MR, van der Donk WA. Use of lantibiotic synthetases for the preparation of bioactive constrained peptides. Bioorganic & Medicinal Chemistry Letters. 18: 3025-8. PMID 18294843 DOI: 10.1016/j.bmcl.2008.01.062  0.822
2007 Whitteck JT, Ni W, Griffin BM, Eliot AC, Thomas PM, Kelleher NL, Metcalf WW, van der Donk WA. Reassignment of the structure of the antibiotic A53868 reveals an unusual amino dehydrophosphonic acid. Angewandte Chemie (International Ed. in English). 46: 9089-92. PMID 17990255 DOI: 10.1002/Anie.200703810  0.778
2007 Fogle EJ, van der Donk WA. Pre-steady-state studies of phosphite dehydrogenase demonstrate that hydride transfer is fully rate limiting. Biochemistry. 46: 13101-8. PMID 17949110 DOI: 10.1021/bi701550c  0.734
2007 Levengood MR, Patton GC, van der Donk WA. The leader peptide is not required for post-translational modification by lacticin 481 synthetase. Journal of the American Chemical Society. 129: 10314-5. PMID 17676843 DOI: 10.1021/ja072967+  0.814
2007 Blodgett JA, Thomas PM, Li G, Velasquez JE, van der Donk WA, Kelleher NL, Metcalf WW. Unusual transformations in the biosynthesis of the antibiotic phosphinothricin tripeptide. Nature Chemical Biology. 3: 480-5. PMID 17632514 DOI: 10.1038/Nchembio.2007.9  0.723
2007 Li B, van der Donk WA. Identification of essential catalytic residues of the cyclase NisC involved in the biosynthesis of nisin. The Journal of Biological Chemistry. 282: 21169-75. PMID 17513866 DOI: 10.1074/Jbc.M701802200  0.416
2007 Willey JM, van der Donk WA. Lantibiotics: peptides of diverse structure and function. Annual Review of Microbiology. 61: 477-501. PMID 17506681 DOI: 10.1146/annurev.micro.61.080706.093501  0.356
2007 McGinley CM, Jacquot C, van der Donk WA. Synthesis of 7-thiaarachidonic acid as a mechanistic probe of prostaglandin H synthase-2. Bioorganic & Medicinal Chemistry Letters. 17: 4049-52. PMID 17485208 DOI: 10.1016/J.Bmcl.2007.04.073  0.713
2007 Paul M, Patton GC, van der Donk WA. Mutants of the zinc ligands of lacticin 481 synthetase retain dehydration activity but have impaired cyclization activity. Biochemistry. 46: 6268-76. PMID 17480057 DOI: 10.1021/Bi7000104  0.811
2007 You YO, van der Donk WA. Mechanistic investigations of the dehydration reaction of lacticin 481 synthetase using site-directed mutagenesis. Biochemistry. 46: 5991-6000. PMID 17455908 DOI: 10.1021/Bi602663X  0.544
2007 Woodyer RD, Li G, Zhao H, van der Donk WA. New insight into the mechanism of methyl transfer during the biosynthesis of fosfomycin. Chemical Communications (Cambridge, England). 359-61. PMID 17220970 DOI: 10.1039/B614678C  0.301
2007 Li G, van der Donk WA. Efficient synthesis of suitably protected beta-difluoroalanine and gamma-difluorothreonine from L-ascorbic acid. Organic Letters. 9: 41-4. PMID 17192080 DOI: 10.1021/ol062401a  0.347
2007 van der Donk WA, Booker SJ. Never stop questioning Current Opinion in Chemical Biology. 11: 527-528. DOI: 10.1016/J.Cbpa.2007.08.022  0.488
2006 McGinley CM, van der Donk WA. Synthesis of site-specifically deuterated arachidonic acid derivatives containing a remote tritium radiolabel. Journal of Labelled Compounds & Radiopharmaceuticals. 49: 545-558. PMID 20414469 DOI: 10.1002/jlcr.1073  0.642
2006 Levengood MR, van der Donk WA. Dehydroalanine-containing peptides: preparation from phenylselenocysteine and utility in convergent ligation strategies. Nature Protocols. 1: 3001-10. PMID 17406561 DOI: 10.1038/nprot.2006.470  0.817
2006 Woodyer RD, Shao Z, Thomas PM, Kelleher NL, Blodgett JA, Metcalf WW, van der Donk WA, Zhao H. Heterologous production of fosfomycin and identification of the minimal biosynthetic gene cluster. Chemistry & Biology. 13: 1171-82. PMID 17113999 DOI: 10.1016/J.Chembiol.2006.09.007  0.589
2006 McClerren AL, Cooper LE, Quan C, Thomas PM, Kelleher NL, van der Donk WA. Discovery and in vitro biosynthesis of haloduracin, a two-component lantibiotic. Proceedings of the National Academy of Sciences of the United States of America. 103: 17243-8. PMID 17085596 DOI: 10.1073/Pnas.0606088103  0.688
2006 Chatterjee C, Patton GC, Cooper L, Paul M, van der Donk WA. Engineering dehydro amino acids and thioethers into peptides using lacticin 481 synthetase. Chemistry & Biology. 13: 1109-17. PMID 17052615 DOI: 10.1016/J.Chembiol.2006.08.015  0.835
2006 Liu W, Wang LH, Fabian P, Hayashi Y, McGinley CM, van der Donk WA, Kulmacz RJ. Arabidopsis thaliana fatty acid alpha-dioxygenase-1: evaluation of substrates, inhibitors and amino-terminal function. Plant Physiology and Biochemistry : Ppb / SociéTé FrançAise De Physiologie VéGéTale. 44: 284-93. PMID 16889973 DOI: 10.1016/j.plaphy.2006.06.013  0.647
2006 Pesavento RP, Pratt DA, Jeffers J, van der Donk WA. Model studies of the Cu(B) site of cytochrome c oxidase utilizing a Zn(II) complex containing an imidazole-phenol cross-linked ligand. Dalton Transactions (Cambridge, England : 2003). 3326-37. PMID 16820845 DOI: 10.1039/B516090A  0.782
2006 Woodyer R, van der Donk WA, Zhao H. Optimizing a biocatalyst for improved NAD(P)H regeneration: directed evolution of phosphite dehydrogenase. Combinatorial Chemistry & High Throughput Screening. 9: 237-45. PMID 16724915 DOI: 10.2174/138620706776843246  0.362
2006 Li B, Yu JP, Brunzelle JS, Moll GN, van der Donk WA, Nair SK. Structure and mechanism of the lantibiotic cyclase involved in nisin biosynthesis. Science (New York, N.Y.). 311: 1464-7. PMID 16527981 DOI: 10.1126/Science.1121422  0.381
2006 Miller LM, Chatterjee C, van der Donk WA, Kelleher NL. The dehydratase activity of lacticin 481 synthetase is highly processive. Journal of the American Chemical Society. 128: 1420-1. PMID 16448091 DOI: 10.1021/Ja057203D  0.526
2006 Pratt DA, van der Donk WA. On the role of alkylcobalamins in the vitamin B12-catalyzed reductive dehalogenation of perchloroethylene and trichloroethylene. Chemical Communications (Cambridge, England). 558-60. PMID 16432582 DOI: 10.1039/B513624E  0.503
2006 McGinley CM, Relyea HA, Van Der Donk WA. Vitamin B12 catalyzed radical cyclizations of arylalkenes Synlett. 211-214. DOI: 10.1055/S-2005-923588  0.777
2006 Relyea HA, van der Donk WA. Nature's way to make the lantibiotics Journal of Chemical Education. 83: 1769-1778. DOI: 10.1021/Ed083P1769  0.775
2005 Chatterjee C, Miller LM, Leung YL, Xie L, Yi M, Kelleher NL, van der Donk WA. Lacticin 481 synthetase phosphorylates its substrate during lantibiotic production. Journal of the American Chemical Society. 127: 15332-3. PMID 16262372 DOI: 10.1021/Ja0543043  0.712
2005 Patton GC, van der Donk WA. New developments in lantibiotic biosynthesis and mode of action. Current Opinion in Microbiology. 8: 543-51. PMID 16118063 DOI: 10.1016/j.mib.2005.08.008  0.763
2005 Woodyer R, Zhao H, van der Donk WA. Mechanistic investigation of a highly active phosphite dehydrogenase mutant and its application for NADPH regeneration. The Febs Journal. 272: 3816-27. PMID 16045753 DOI: 10.1111/J.1742-4658.2005.04788.X  0.37
2005 Pratt DA, Pesavento RP, van der Donk WA. Model studies of the histidine-tyrosine cross-link in cytochrome C oxidase reveal the flexible substituent effect of the imidazole moiety. Organic Letters. 7: 2735-8. PMID 15957934 DOI: 10.1021/Ol050916G  0.776
2005 Galoni? DP, Ide ND, van der Donk WA, Gin DY. Aziridine-2-carboxylic acid-containing peptides: application to solution- and solid-phase convergent site-selective peptide modification. Journal of the American Chemical Society. 127: 7359-69. PMID 15898784 DOI: 10.1021/Ja050304R  0.348
2005 Relyea HA, van der Donk WA. Mechanism and applications of phosphite dehydrogenase. Bioorganic Chemistry. 33: 171-89. PMID 15888310 DOI: 10.1016/J.Bioorg.2005.01.003  0.798
2005 Relyea HA, Vrtis JM, Woodyer R, Rimkus SA, van der Donk WA. Inhibition and pH dependence of phosphite dehydrogenase. Biochemistry. 44: 6640-9. PMID 15850397 DOI: 10.1021/Bi047640P  0.768
2005 Woodyer R, Wheatley JL, Relyea HA, Rimkus S, van der Donk WA. Site-directed mutagenesis of active site residues of phosphite dehydrogenase. Biochemistry. 44: 4765-74. PMID 15779903 DOI: 10.1021/Bi047868C  0.815
2005 Woodyer R, Simurdiak M, van der Donk WA, Zhao H. Heterologous expression, purification, and characterization of a highly active xylose reductase from Neurospora crassa. Applied and Environmental Microbiology. 71: 1642-7. PMID 15746370 DOI: 10.1128/Aem.71.3.1642-1647.2005  0.364
2005 Chatterjee C, Paul M, Xie L, van der Donk WA. Biosynthesis and mode of action of lantibiotics. Chemical Reviews. 105: 633-84. PMID 15700960 DOI: 10.1021/Cr030105V  0.675
2005 McCauley KM, Pratt DA, Wilson SR, Shey J, Burkey TJ, van der Donk WA. Properties and reactivity of chlorovinylcobalamin and vinylcobalamin and their implications for vitamin B12-catalyzed reductive dechlorination of chlorinated alkenes. Journal of the American Chemical Society. 127: 1126-36. PMID 15669852 DOI: 10.1021/Ja048573P  0.782
2005 Pratt DA, van der Donk WA. Theoretical investigations into the intermediacy of chlorinated vinylcobalamins in the reductive dehalogenation of chlorinated ethylenes. Journal of the American Chemical Society. 127: 384-96. PMID 15631489 DOI: 10.1021/Ja047915O  0.513
2005 Paul M, van der Donk WA. Chemical and enzymatic synthesis of lanthionines Mini-Reviews in Organic Chemistry. 2: 23-37. DOI: 10.2174/1570193052774108  0.532
2005 Ide ND, Galoni? DP, Van Der Donk WA, Gin DY. Conjugation of selenols with aziridine-2-carboxylic acid-containing peptides Synlett. 2011-2014. DOI: 10.1055/S-2005-871972  0.336
2005 Van Der Donk WA, Pratt DA. Mechanistic aspects of chlorinated ethylene degradation by vitamin B12 Acs National Meeting Book of Abstracts. 230.  0.467
2004 Galoni? DP, van der Donk WA, Gin DY. Site-selective conjugation of thiols with aziridine-2-carboxylic acid-containing peptides. Journal of the American Chemical Society. 126: 12712-3. PMID 15469231 DOI: 10.1021/ja046793x  0.325
2004 Xie L, van der Donk WA. Post-translational modifications during lantibiotic biosynthesis. Current Opinion in Chemical Biology. 8: 498-507. PMID 15450492 DOI: 10.1016/J.Cbpa.2004.08.005  0.556
2004 Ralle M, Berry SM, Nilges MJ, Gieselman MD, van der Donk WA, Lu Y, Blackburn NJ. The selenocysteine-substituted blue copper center: spectroscopic investigations of Cys112SeCys Pseudomonas aeruginosa azurin. Journal of the American Chemical Society. 126: 7244-56. PMID 15186162 DOI: 10.1021/Ja031821H  0.77
2004 Xie L, Miller LM, Chatterjee C, Averin O, Kelleher NL, van der Donk WA. Lacticin 481: in vitro reconstitution of lantibiotic synthetase activity. Science (New York, N.Y.). 303: 679-81. PMID 14752162 DOI: 10.1126/Science.1092600  0.688
2004 Peng S, McGinley CM, van der Donk WA. Synthesis of site-specifically labeled arachidonic acids as mechanistic probes for prostaglandin H synthase. Organic Letters. 6: 349-52. PMID 14748590 DOI: 10.1021/ol0361711  0.644
2003 McGinley CM, van der Donk WA. Enzymatic hydrogen atom abstraction from polyunsaturated fatty acids. Chemical Communications (Cambridge, England). 2843-6. PMID 14680206  0.607
2003 Zhao H, van der Donk WA. Regeneration of cofactors for use in biocatalysis. Current Opinion in Biotechnology. 14: 583-9. PMID 14662386 DOI: 10.1016/J.Copbio.2003.09.007  0.348
2003 Okeley NM, Paul M, Stasser JP, Blackburn N, van der Donk WA. SpaC and NisC, the cyclases involved in subtilin and nisin biosynthesis, are zinc proteins. Biochemistry. 42: 13613-24. PMID 14622008 DOI: 10.1021/Bi0354942  0.822
2003 Zhou H, Schmidt DMZ, Gerlt JA, Van Der Donk WA. Chemical and Enzymatic Synthesis of Fluorinated-Dehydroalanine-Containing Peptides Chembiochem. 4: 1206-1215. PMID 14613113 DOI: 10.1002/Cbic.200300654  0.405
2003 Zhu Y, Gieselman MD, Zhou H, Averin O, van der Donk WA. Biomimetic studies on the mechanism of stereoselective lanthionine formation. Organic & Biomolecular Chemistry. 1: 3304-15. PMID 14584794 DOI: 10.1039/B304945K  0.826
2003 Woodyer R, van der Donk WA, Zhao H. Relaxing the nicotinamide cofactor specificity of phosphite dehydrogenase by rational design. Biochemistry. 42: 11604-14. PMID 14529270 DOI: 10.1021/Bi035018B  0.404
2003 van der Donk WA, Zhao H. Recent developments in pyridine nucleotide regeneration. Current Opinion in Biotechnology. 14: 421-6. PMID 12943852 DOI: 10.1016/S0958-1669(03)00094-6  0.366
2003 McCauley KM, Wilson SR, van der Donk WA. Characterization of chlorovinylcobalamin, a putative intermediate in reductive degradation of chlorinated ethylenes. Journal of the American Chemical Society. 125: 4410-1. PMID 12683797 DOI: 10.1021/Ja029692C  0.682
2002 McCauley KM, Wilson SR, van der Donk WA. Dichloroacetylene is not the precursor to dichlorinated vinylcobaloxime and vinylcobalamin in cobalt catalyzed dechlorination of perchloro- and trichloroethylene. Inorganic Chemistry. 41: 5844-8. PMID 12401092 DOI: 10.1021/Ic025714K  0.691
2002 Peng S, Okeley NM, Tsai AL, Wu G, Kulmacz RJ, van der Donk WA. Synthesis of isotopically labeled arachidonic acids to probe the reaction mechanism of prostaglandin H synthase. Journal of the American Chemical Society. 124: 10785-96. PMID 12207535 DOI: 10.1021/Ja026880U  0.739
2002 Vrtis JM, White AK, Metcalf WW, van der Donk WA. Phosphite dehydrogenase: a versatile cofactor-regeneration enzyme. Angewandte Chemie (International Ed. in English). 41: 3257-9. PMID 12207407 DOI: 10.1002/1521-3773(20020902)41:17<3257::Aid-Anie3257>3.0.Co;2-N  0.783
2002 Gieselman MD, Zhu Y, Zhou H, Galonic D, van der Donk WA. Selenocysteine derivatives for chemoselective ligations. Chembiochem : a European Journal of Chemical Biology. 3: 709-16. PMID 12203969 DOI: 10.1002/1439-7633(20020802)3:8<709::Aid-Cbic709>3.0.Co;2-8  0.769
2002 Tsai AL, Palmer G, Wu G, Peng S, Okeley NM, van der Donk WA, Kulmacz RJ. Structural characterization of arachidonyl radicals formed by aspirin-treated prostaglandin H synthase-2. The Journal of Biological Chemistry. 277: 38311-21. PMID 12167656 DOI: 10.1074/Jbc.M206961200  0.699
2002 Xie L, Chatterjee C, Balsara R, Okeley NM, van der Donk WA. Heterologous expression and purification of SpaB involved in subtilin biosynthesis. Biochemical and Biophysical Research Communications. 295: 952-7. PMID 12127987 DOI: 10.1016/S0006-291X(02)00783-0  0.831
2002 Berry SM, Gieselman MD, Nilges MJ, van Der Donk WA, Lu Y. An engineered azurin variant containing a selenocysteine copper ligand. Journal of the American Chemical Society. 124: 2084-5. PMID 11878940 DOI: 10.1021/Ja0169163  0.796
2002 Shey J, McGinley CM, McCauley KM, Dearth AS, Young BT, van der Donk WA. Mechanistic investigation of a novel vitamin B(12)-catalyzed carbon [bond] carbon bond forming reaction, the reductive dimerization of arylalkenes. The Journal of Organic Chemistry. 67: 837-46. PMID 11856027 DOI: 10.1021/Jo0160470  0.788
2002 McCauley KM, Wilson SR, van der Donk WA. Synthesis and characterization of chlorinated alkenylcobaloximes to probe the mechanism of vitamin B(12)-catalyzed dechlorination of priority pollutants. Inorganic Chemistry. 41: 393-404. PMID 11800630 DOI: 10.1021/Ic011023X  0.674
2001 Xie L, van der Donk WA. Homemade cofactors: self-processing in galactose oxidase. Proceedings of the National Academy of Sciences of the United States of America. 98: 12863-5. PMID 11698675 DOI: 10.1073/Pnas.231485998  0.501
2001 Pesavento RP, van der Donk WA. Tyrosyl radical cofactors. Advances in Protein Chemistry. 58: 317-85. PMID 11665491 DOI: 10.1016/S0065-3233(01)58008-0  0.792
2001 Peng S, Okeley NM, Tsai AL, Wu G, Kulmacz RJ, van der Donk WA. Structural characterization of a pentadienyl radical intermediate formed during catalysis by prostaglandin H synthase-2. Journal of the American Chemical Society. 123: 3609-10. PMID 11472139 DOI: 10.1021/Ja015599X  0.697
2001 Vrtis JM, White AK, Metcalf WW, van der Donk WA. Phosphite dehydrogenase: an unusual phosphoryl transfer reaction. Journal of the American Chemical Society. 123: 2672-3. PMID 11456941 DOI: 10.1021/ja004301k  0.767
2001 Gieselman MD, Xie L, van Der Donk WA. Synthesis of a selenocysteine-containing peptide by native chemical ligation. Organic Letters. 3: 1331-4. PMID 11348227 DOI: 10.1021/Ol015712O  0.826
2001 Zhu Y, van der Donk WA. Convergent synthesis of peptide conjugates using dehydroalanines for chemoselective ligations. Organic Letters. 3: 1189-92. PMID 11348191 DOI: 10.1021/Ol015648A  0.804
2001 Zhou H, van der Donk WA. Synthesis of 2-amino-3-fluoroacrylic acid containing peptides. Organic Letters. 3: 593-6. PMID 11178833  0.372
2000 Okeley NM, Zhu Y, van Der Donk WA. Facile chemoselective synthesis of dehydroalanine-containing peptides. Organic Letters. 2: 3603-6. PMID 11073655 DOI: 10.1021/Ol006485D  0.827
2000 Okeley NM, van der Donk WA. Novel cofactors via post-translational modifications of enzyme active sites. Chemistry & Biology. 7: R159-71. PMID 10903941 DOI: 10.1016/S1074-5521(00)00140-X  0.727
1998 Stubbe J, van Der Donk WA. Protein Radicals in Enzyme Catalysis. [Chem. Rev. 1998, 98, 705minus sign762. Chemical Reviews. 98: 2661-2662. PMID 11848974 DOI: 10.1021/Cr980059C  0.454
1998 Stubbe J, van Der Donk WA. Protein Radicals in Enzyme Catalysis. Chemical Reviews. 98: 705-762. PMID 11848913  0.454
1998 van der Donk WA, Yu G, Pérez L, Sanchez RJ, Stubbe J, Samano V, Robins MJ. Detection of a new substrate-derived radical during inactivation of ribonucleotide reductase from Escherichia coli by gemcitabine 5'-diphosphate. Biochemistry. 37: 6419-26. PMID 9572859 DOI: 10.1021/Bi9729357  0.437
1996 van der Donk WA, Zeng C, Biemann K, Stubbe J, Hanlon A, Kyte J. Identification of an active site residue of the R1 subunit of ribonucleotide reductase from Escherichia coli: characterization of substrate-induced polypeptide cleavage by C225SR1. Biochemistry. 35: 10058-67. PMID 8756468 DOI: 10.1021/Bi952869D  0.557
1996 van der Donk WA, Yu G, Silva DJ, Stubbe J, McCarthy JR, Jarvi ET, Matthews DP, Resvick RJ, Wagner E. Inactivation of ribonucleotide reductase by (E)-2'-fluoromethylene-2'-deoxycytidine 5'-diphosphate: a paradigm for nucleotide mechanism-based inhibitors. Biochemistry. 35: 8381-91. PMID 8679596 DOI: 10.1021/Bi960190J  0.447
1995 Stubbe J, van der Donk WA. Ribonucleotide reductases: radical enzymes with suicidal tendencies. Chemistry & Biology. 2: 793-801. PMID 8807812  0.458
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