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High-probability grants
According to our matching algorithm, Charles F. Landry is the likely recipient of the following grants.
Years |
Recipients |
Code |
Title / Keywords |
Matching score |
2000 — 2002 |
Landry, Charles F |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Gene Expression Profile in Response to Drug Paired Cues @ University of Wisconsin Madison
DESCRIPTION: (Applicant's Abstract) Substance abuse is the number one public health problem in the United States. Although the causes of addiction are complex and multifactorial, conditioning and learning factors may play a primary role in the development of addiction, and in particular in relapse to drug use. Despite the recognition that the occurrence of drug craving and relapse is in part driven by a learning process, and that drugs of abuse have clear effects on cellular plasticity, there has been very little attempt to integrate these two important notions, and to investigate the molecular mechanisms underlying conditioned responses to drug-related environmental cues. Data from both human and animal studies suggest that the prefrontal cortex is involved in the conditioned response to biological rewards and drug-related cues. An understanding of the complex pattern of cellular and genomic activity in prefrontal regions during conditioned craving could potentially be of great value to medications development. The process of addiction is likely to involve both temporary and permanent changes in gene expression and protein synthesis. However, progress has been limited by the extremely labor-intensive demands of investigating the role of individual genes or small groups of genes in complex cognitive or behavioral paradigms. The advent of DNA microarray technology is likely to change this limitation dramatically. This technology enables fast, parallel analysis of gene expression and the simultaneous monitoring of thousands of transcripts. We have recently developed a rat model of drug-associated classical conditioning. Thus, the question that forms the basis for this proposal is whether a distinct pattern of gene expression is observed in prefrontal cortex during exposure to drug-paired cues. We hypothesize that changes in the expression of specific genes are an essential component of the substrate for drug expectancy in animals (and perhaps drug craving in humans), and that the same sets of genes are involved in the conditioning response regardless of the addictive substance used. To test this hypothesis, we will apply DNA microarray analysis, employing several types of microarrays, to the drug conditioning paradigm. Our goal is to generate a "signature" of genes that are altered in the context of drug-related conditioning, with the ultimate aim of identifying molecular pathways important in this coqnitive state and behavior.
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1 |
2004 — 2006 |
Landry, Charles F |
R01Activity Code Description: To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Nicotine and Gene Expression in Adolescent Brain @ University of Wisconsin Madison
DESCRIPTION (provided by applicant): Adolescence is a particularly vulnerable period in development that is marked by an increase in novelty-seeking and risk-taking behaviors. Although beneficial in encouraging exploration and experimentation as adolescents prepare for life in an adult world, these behaviors may also contribute to the high incidence of smoking in the adolescent population. Since regions of the brain like the prefrontal cortex, which are important for emotional regulation and behavioral control, continue to develop throughout this period, it is likely that an immature brain contributes to the problem of nicotine addiction in the adolescent population. Because of the difficulty in examining nicotine addiction in human adolescents, the rodent model has become a powerful tool for examining the behavioral and molecular underpinnings of the adolescent response to nicotine. Using this model, we have begun to identify genes in the adolescent prefrontal cortex that are differentially expressed compared to the adult following acute nicotine treatment. We have also found that, unlike adults, adolescents do not condition to a nicotine-paired environment. The focus of this proposal is to further examine the molecular substrates involved in the development of the prefrontal cortex and to determine the influence of nicotine on these substrates. In addition, the influence of stress on nicotine-paired conditioning in adolescents will be performed. Insights into the molecular and behavioral components that differ between adolescent and adult brain, and an understanding of how these differences relate to addiction and craving, may lead to more effective interventions.
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1 |