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David L. DeMets - Publications

Affiliations: 
University of Wisconsin, Madison, Madison, WI 
Area:
Statistics, Biostatistics Biology
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Year Citation  Score
2022 Huang Z, Rockhold FW, Jones WS, Hernandez AF, McCall D, DeMets DL, Hochman JS, Gersh BJ, Campos H, Jacobs AK, Yancy CW. The challenges of data safety monitoring for a pragmatic study: Lessons from the ADAPTABLE study. Contemporary Clinical Trials. 106732. PMID 35301133 DOI: 10.1016/j.cct.2022.106732  0.31
2020 Docherty KF, Jhund PS, Bengtsson O, DeMets DL, Inzucchi SE, Køber L, Kosiborod MN, Langkilde AM, Martinez FA, Sabatine MS, Sjöstrand M, Solomon SD, McMurray JJV. Effect of Dapagliflozin in DAPA-HF According to Background Glucose-Lowering Therapy. Diabetes Care. 43: 2878-2881. PMID 33082245 DOI: 10.2337/Dc20-1402  0.332
2020 Docherty KF, Jhund PS, Anand I, Bengtsson O, Böhm M, de Boer RA, DeMets DL, Desai AS, Drozdz J, Howlett J, Inzucchi SE, Johanson P, Katova T, Køber L, Kosiborod MN, et al. Effect of Dapagliflozin on Outpatient Worsening of Patients with Heart Failure and Reduced Ejection Fraction: A Prespecified Analysis of DAPA-HF. Circulation. PMID 32883108 DOI: 10.1161/Circulationaha.120.047480  0.345
2020 Serenelli M, Böhm M, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Solomon SD, DeMets DL, Bengtsson O, Sjöstrand M, Langkilde AM, Anand IS, Chiang CE, et al. Effect of dapagliflozin according to baseline systolic blood pressure in the Dapagliflozin and Prevention of Adverse Outcomes in Heart Failure trial (DAPA-HF). European Heart Journal. PMID 32820334 DOI: 10.1093/Eurheartj/Ehaa496  0.342
2020 Jackson AM, Dewan P, Anand IS, Bělohlávek J, Bengtsson O, de Boer RA, Böhm M, Boulton DW, Chopra VK, Demets DL, Docherty KF, Dukát A, Greasley PJ, Howlett JG, Inzucchi SE, et al. Dapagliflozin and Diuretic Use in Patients with Heart Failure and Reduced Ejection Fraction in DAPA-HF. Circulation. PMID 32673497 DOI: 10.1161/Circulationaha.120.047077  0.361
2020 DeMets DL, Fleming TR. Achieving Effective Informed Oversight by DMCs in COVID Clinical Trials. Journal of Clinical Epidemiology. PMID 32659363 DOI: 10.1016/J.Jclinepi.2020.07.001  0.418
2020 Dewan P, Solomon SD, Jhund PS, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, DeMets DL, Sabatine MS, Bengtsson O, Sjöstrand M, Langkilde AM, Anand IS, Bělohlávek J, et al. Efficacy and safety of sodium-glucose co-transporter 2 inhibition according to left ventricular ejection fraction in DAPA-HF. European Journal of Heart Failure. PMID 32539224 DOI: 10.1002/Ejhf.1867  0.322
2020 Brenner J, LeBlang S, Lizotte-Waniewski M, Schmidt B, Espinosa PS, DeMets DL, Newberg A, Hennekens CH. Mindfulness with paced breathing reduces blood pressure. Medical Hypotheses. 142: 109780. PMID 32353795 DOI: 10.1016/J.Mehy.2020.109780  0.335
2020 Docherty KF, Jhund PS, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, DeMets DL, Sabatine MS, Bengtsson O, Sjöstrand M, Langkilde AM, Desai AS, Diez M, Howlett JG, et al. Effects of dapagliflozin in DAPA-HF according to background heart failure therapy. European Heart Journal. PMID 32221582 DOI: 10.1093/Eurheartj/Ehaa183  0.319
2020 Acharya A, Glurich I, Hetzel S, Kim K, Tattersall MC, DeMets DL, Hennekens CH. Correlation between Oral Health and Systemic Inflammation (COHESION): A Randomized Pilot Follow Up Trial of a Plaque Identifying Toothpaste. The American Journal of Medicine. PMID 32105658 DOI: 10.1016/J.Amjmed.2020.01.023  0.311
2019 Kosiborod MN, Jhund P, Docherty KF, Diez M, Petrie MC, Verma S, Nicolau JC, Merkely B, Kitakaze M, DeMets DL, Inzucchi SE, Køeber L, Martinez FA, Ponikowski P, Sabatine MS, et al. Effects of Dapagliflozin on Symptoms, Function and Quality of Life in Patients with Heart Failure and Reduced Ejection Fraction: Results from the DAPA-HF Trial. Circulation. PMID 31736335 DOI: 10.1161/Circulationaha.119.044138  0.356
2019 Martinez FA, Serenelli M, Nicolau JC, Petrie MC, Chiang CE, Tereshchenko S, Solomon SD, Inzucchi SE, Køber L, Kosiborod MN, Ponikowski P, Sabatine MS, Demets DL, Dutkiewicz-Piasecka M, Bengtsson O, et al. Efficacy and Safety of Dapagliflozin in Heart Failure With Reduced Ejection Fraction According to Age: Insights From DAPA-HF. Circulation. PMID 31736328 DOI: 10.1161/Circulationaha.119.044133  0.346
2019 McMurray JJV, DeMets DL, Inzucchi SE, Køber L, Kosiborod MN, Langkilde AM, Martinez FA, Bengtsson O, Ponikowski P, Sabatine MS, Sjöstrand M, Solomon SD. The Dapagliflozin And Prevention of Adverse-outcomes in Heart Failure (DAPA-HF) trial: baseline characteristics. European Journal of Heart Failure. PMID 31309699 DOI: 10.1002/Ejhf.1548  0.367
2019 Cairns JA, Eikelboom JW, Shestakovska O, Yusuf S, DeMets D. Monitoring Emerging Data From the COMPASS Trial of an Antithrombotic Agent. Journal of the American College of Cardiology. 73: 2769-2772. PMID 31146821 DOI: 10.1016/J.Jacc.2019.03.479  0.414
2019 McMurray JJV, DeMets DL, Inzucchi SE, Køber L, Kosiborod MN, Langkilde AM, Martinez FA, Bengtsson O, Ponikowski P, Sabatine MS, Sjöstrand M, Solomon SD. A trial to evaluate the effect of the sodium-glucose co-transporter 2 inhibitor dapagliflozin on morbidity and mortality in patients with heart failure and reduced left ventricular ejection fraction (DAPA-HF). European Journal of Heart Failure. PMID 30895697 DOI: 10.1002/Ejhf.1432  0.339
2018 DeMets D. The independent statistician model: How well is it working? Clinical Trials. 15: 329-334. PMID 29741390 DOI: 10.1177/1740774518772841  0.389
2018 Fleming TR, Ellenberg SS, DeMets DL. Data Monitoring Committees: Current issues. Clinical Trials (London, England). 1740774518764855. PMID 29629815 DOI: 10.1177/1740774518764855  0.413
2017 Calis KA, Archdeacon P, Bain R, DeMets D, Donohue M, Elzarrad MK, Forrest A, McEachern J, Pencina MJ, Perlmutter J, Lewis RJ. Recommendations for data monitoring committees from the Clinical Trials Transformation Initiative. Clinical Trials (London, England). 1740774517707743. PMID 28503947 DOI: 10.1177/1740774517707743  0.399
2017 Packer M, Pitt B, Rouleau JL, Swedberg K, DeMets DL, Fisher L. Long-Term Effects of Flosequinan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure: Primary Results of the PROFILE Trial After 24 Years. Jacc. Heart Failure. PMID 28501522 DOI: 10.1016/J.Jchf.2017.03.003  0.349
2017 Packer M, McMurray JJV, Krum H, Kiowski W, Massie BM, Caspi A, Pratt CM, Petrie MC, DeMets D, Kobrin I, Roux S, Swedberg K. Long-Term Effect of Endothelin Receptor Antagonism With Bosentan on the Morbidity and Mortality of Patients With Severe Chronic Heart Failure: Primary Results of the ENABLE Trials. Jacc. Heart Failure. 5: 317-326. PMID 28449795 DOI: 10.1016/J.Jchf.2017.02.021  0.34
2017 Fleming TR, DeMets DL, Roe MT, Wittes J, Calis KA, Vora AN, Meisel A, Bain RP, Konstam MA, Pencina MJ, Gordon DJ, Mahaffey KW, Hennekens CH, Neaton JD, Pearson GD, et al. Data monitoring committees: Promoting best practices to address emerging challenges. Clinical Trials (London, England). 14: 115-123. PMID 28359194 DOI: 10.1177/1740774516688915  0.358
2017 Kalscheur MM, Saxon LA, Lee BK, Steinberg JS, Mei C, Buhr KA, DeMets DL, Bristow MR, Singh SN. Outcomes of Cardiac Resynchronization Therapy in Patients with Intermittent Atrial Fibrillation or Atrial Flutter in the COMPANION Trial. Heart Rhythm. PMID 28323173 DOI: 10.1016/J.Hrthm.2017.03.024  0.33
2016 Lewis RJ, Calis KA, DeMets DL. Enhancing the Scientific Integrity and Safety of Clinical Trials: Recommendations for Data Monitoring Committees. Jama. 316: 2359-2360. PMID 27960001 DOI: 10.1001/Jama.2016.16070  0.381
2016 Calis KA, Archdeacon P, Bain RP, Forrest A, Perlmutter J, DeMets DL. Understanding the functions and operations of data monitoring committees: Survey and focus group findings. Clinical Trials (London, England). PMID 27885056 DOI: 10.1177/1740774516679665  0.349
2016 Fasula K, Evans CA, Boyd L, Giblin L, Belavsky BZ, Hetzel S, McBride P, DeMets DL, Hennekens CH. Randomized trial of Plaque identifying Toothpaste: Dental Plaque and Inflammation. The American Journal of Medicine. PMID 27771276 DOI: 10.1016/J.Amjmed.2016.09.003  0.32
2016 DeMets DL, Ellenberg SS. Data Monitoring Committees - Expect the Unexpected. The New England Journal of Medicine. 375: 1365-1371. PMID 27705256 DOI: 10.1056/Nejmra1510066  0.422
2016 Lo B, DeMets DL. Incentives for Clinical Trialists to Share Data. The New England Journal of Medicine. 375: 1112-5. PMID 27653562 DOI: 10.1056/Nejmp1608351  0.314
2016 Collins R, Reith C, Emberson J, Armitage J, Baigent C, Blackwell L, Blumenthal R, Danesh J, Smith GD, DeMets D, Evans S, Law M, MacMahon S, Martin S, Neal B, et al. Interpretation of the evidence for the efficacy and safety of statin therapy. Lancet (London, England). PMID 27616593 DOI: 10.1016/S0140-6736(16)31357-5  0.333
2016 Bristow MR, Saxon LA, Feldman AM, Mei C, Anderson SA, DeMets DL. Lessons Learned and Insights Gained in the Design, Analysis, and Outcomes of the COMPANION Trial. Jacc. Heart Failure. PMID 27289408 DOI: 10.1016/J.Jchf.2016.02.019  0.38
2015 Antman EM, Benjamin EJ, Harrington RA, Houser SR, Peterson ED, Bauman MA, Brown N, Bufalino V, Califf RM, Creager MA, Daugherty A, Demets DL, Dennis BP, Ebadollahi S, Jessup M, et al. Acquisition, Analysis, and Sharing of Data in 2015 and Beyond: A Survey of the Landscape: A Conference Report From the American Heart Association Data Summit 2015. Journal of the American Heart Association. 4. PMID 26541391 DOI: 10.1161/Jaha.115.002810  0.329
2015 Yang F, Stewart M, Ye J, DeMets D. Type 2 diabetes mellitus development programs in the new regulatory environment with cardiovascular safety requirements. Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy. 8: 315-25. PMID 26229496 DOI: 10.2147/Dmso.S84005  0.319
2015 Fordyce CB, Roe MT, Ahmad T, Libby P, Borer JS, Hiatt WR, Bristow MR, Packer M, Wasserman SM, Braunstein N, Pitt B, DeMets DL, Cooper-Arnold K, Armstrong PW, Berkowitz SD, et al. Cardiovascular drug development: is it dead or just hibernating? Journal of the American College of Cardiology. 65: 1567-82. PMID 25881939 DOI: 10.1016/J.Jacc.2015.03.016  0.311
2015 DeMets DL, Wittes JT, Geller NL. The Influence of Biostatistics at the National Heart, Lung, and Blood Institute American Statistician. 69: 108-120. DOI: 10.1080/00031305.2015.1035962  0.378
2014 Fleming TR, Hennekens CH, Pfeffer MA, DeMets DL. Enhancing trial integrity by protecting the independence of data monitoring committees in clinical trials. Journal of Biopharmaceutical Statistics. 24: 968-75. PMID 24926941 DOI: 10.1080/10543406.2014.925719  0.409
2013 DeMets D, Wittes J, Siegel J. University of Pennsylvania 5th annual conference on statistical issues in clinical trials: emerging statistical issues in biomarker validation (Morning Session). Clinical Trials (London, England). 10: 680-9. PMID 24130200 DOI: 10.1177/1740774513500388  0.37
2013 Molitor JA, Demets DL. Can large simple trials help us understand when and how to use generic drugs for uncommon diseases? The Journal of Rheumatology. 40: 539-41. PMID 23637373 DOI: 10.3899/Jrheum.130314  0.339
2013 Hetzel S, DeMets D, Schneider R, Borzak S, Schneider W, Serebruany V, Schröder H, Hennekens CH. Aspirin increases nitric oxide formation in chronic stable coronary disease. Journal of Cardiovascular Pharmacology and Therapeutics. 18: 217-21. PMID 23524841 DOI: 10.1177/1074248413482753  0.321
2013 DeMets DL. Data monitoring committees: history and their future. Trials. 14: 1-1. DOI: 10.1186/1745-6215-14-S1-I3  0.434
2012 D'Agostino R, DeMets D, Friedewald W, Goodman S, Witte J, Geller NL. The future of clinical trials: A panel discussion. Statistics in Medicine. 31: 3068-72. PMID 22806631 DOI: 10.1002/Sim.5484  0.366
2012 DeMets DL. Current development in clinical trials: issues old and new. Statistics in Medicine. 31: 2944-54. PMID 22736410 DOI: 10.1002/Sim.5405  0.395
2012 Zheng G, Wu CO, Yang S, Waclawiw MA, DeMets DL, Geller NL. NHLBI clinical trials workshop: an executive summary. Statistics in Medicine. 31: 2938-43. PMID 22733431 DOI: 10.1002/Sim.5406  0.419
2012 Hennekens CH, Hetzel S, Pfeffer M, Schneider R, Borzak S, Schneider W, Serebruany V, DeMets D. Low-dose enteric-coated aspirin does not inhibit thromboxane B2 and prostaglandin E2: data-derived hypothesis formulation Clinical Investigation. 2: 747-752. DOI: 10.4155/Cli.12.56  0.305
2012 DeMets DL, Friedman L. Some Thoughts on Challenges for Noninferiority Study Designs Drug Information Journal. 46: 420-427. DOI: 10.1177/0092861512445310  0.339
2011 DeMets DL, Califf RM. A historical perspective on clinical trials innovation and leadership: where have the academics gone? Jama. 305: 713-4. PMID 21325190 DOI: 10.1001/Jama.2011.175  0.413
2011 Komajda M, Carson PE, Hetzel S, McKelvie R, McMurray J, Ptaszynska A, Zile MR, DeMets D, Massie BM. Factors Associated With Outcome in Heart Failure With Preserved Ejection FractionClinical Perspective Circulation-Heart Failure. 4: 27-35. PMID 21068341 DOI: 10.1161/Circheartfailure.109.932996  0.357
2011 Hennekens CH, DeMets D. Data and safety monitoring boards of randomized trials: evolving principles and practical suggestions Clinical Investigation. 1: 53-57. DOI: 10.4155/Cli.10.11  0.417
2010 Cook T, DeMets DL. Review of draft FDA adaptive design guidance. Journal of Biopharmaceutical Statistics. 20: 1132-42. PMID 21058109 DOI: 10.1080/10543406.2010.514455  0.355
2010 Ellenberg SS, DeMets DL, Fleming TR. Bias and trials stopped early for benefit. Jama. 304: 158; author reply 15. PMID 20628127 DOI: 10.1001/Jama.2010.933  0.377
2010 Hennekens CH, Hebert PR, Schneider WR, O'Brien P, Demets D, Borer JS. Academic perspectives on the United States Food and Drug Administration's guidance for industry on diabetes mellitus. Contemporary Clinical Trials. 31: 411-3. PMID 20601161 DOI: 10.1016/J.Cct.2010.06.001  0.396
2010 Friedman LM, Furberg CD, Demets DL. Fundamentals of clinical trials Fundamentals of Clinical Trials. 1-445. DOI: 10.1007/978-1-4419-1586-3  0.325
2009 Hennekens CH, DeMets D. The need for large-scale randomized evidence without undue emphasis on small trials, meta-analyses, or subgroup analyses. Jama. 302: 2361-2362. PMID 19952322 DOI: 10.1001/Jama.2009.1756  0.452
2009 Metra M, Eichhorn E, Abraham WT, Linseman J, Böhm M, Corbalan R, DeMets D, De Marco T, Elkayam U, Gerber M, Komajda M, Liu P, Mareev V, Perrone SV, Poole-Wilson P, et al. Effects of low-dose oral enoximone administration on mortality, morbidity, and exercise capacity in patients with advanced heart failure: the randomized, double-blind, placebo-controlled, parallel group ESSENTIAL trials. European Heart Journal. 30: 3015-26. PMID 19700774 DOI: 10.1093/Eurheartj/Ehp338  0.354
2009 Anand IS, Carson P, Galle E, Song R, Boehmer J, Ghali JK, Jaski B, Lindenfeld J, O'Connor C, Steinberg JS, Leigh J, Yong P, Kosorok MR, Feldman AM, DeMets D, et al. Cardiac resynchronization therapy reduces the risk of hospitalizations in patients with advanced heart failure: results from the Comparison of Medical Therapy, Pacing and Defibrillation in Heart Failure (COMPANION) trial. Circulation. 119: 969-77. PMID 19204305 DOI: 10.1161/Circulationaha.108.793273  0.32
2009 Lan KKG, DeMets D. Further Comments on the Alpha Spending Function Statistics in Biosciences. 1: 95-111. DOI: 10.1007/S12561-009-9004-3  0.394
2008 Baron JA, Sandler RS, Bresalier RS, Lanas A, Morton DG, Riddell R, Iverson ER, Demets DL. Cardiovascular events associated with rofecoxib: final analysis of the APPROVe trial. Lancet (London, England). 372: 1756-64. PMID 18922570 DOI: 10.1016/S0140-6736(08)61490-7  0.385
2007 Wittes J, Barrett-Connor E, Braunwald E, Chesney M, Cohen HJ, Demets D, Dunn L, Dwyer J, Heaney RP, Vogel V, Walters L, Yusuf S. Monitoring the randomized trials of the Women's Health Initiative: the experience of the Data and Safety Monitoring Board. Clinical Trials (London, England). 4: 218-34. PMID 17715247 DOI: 10.1177/1740774507079439  0.381
2006 Demets DL. Futility approaches to interim monitoring by data monitoring committees. Clinical Trials (London, England). 3: 522-9. PMID 17170036 DOI: 10.1177/1740774506073115  0.431
2006 DeMets DL, Fost N, Powers M. An Institutional Review Board dilemma: responsible for safety monitoring but not in control. Clinical Trials (London, England). 3: 142-8. PMID 16773956 DOI: 10.1191/1740774506Cn137Oa  0.405
2006 Fan X, DeMets DL. Conditional and unconditional confidence intervals following a group sequential test. Journal of Biopharmaceutical Statistics. 16: 107-22. PMID 16440840 DOI: 10.1080/10543400500406595  0.718
2006 Demets DL, Furberg CD, Friedman LM. Data monitoring in clinical trials: A case studies approach Data Monitoring in Clinical Trials: a Case Studies Approach. 1-374. DOI: 10.1007/0-387-30107-0  0.33
2005 Lowes BD, Shakar SF, Metra M, Feldman AM, Eichhorn E, Freytag JW, Gerber MJ, Liard JF, Hartman C, Gorczynski R, Evans G, Linseman JV, Stewart J, Robertson AD, Roecker EB, ... Demets DL, et al. Rationale and design of the enoximone clinical trials program. Journal of Cardiac Failure. 11: 659-69. PMID 16360960 DOI: 10.1016/J.Cardfail.2005.10.013  0.374
2005 Gheorghiade M, Orlandi C, Burnett JC, DeMets D, Grinfeld L, Maggioni A, Swedberg K, Udelson JE, Zannad F, Zimmer C, Konstam MA. Rationale and design of the multicenter, randomized, double-blind, placebo-controlled study to evaluate the efficacy of vasopressin antagonism in heart failure: Outcome study with Tolvaptan (EVEREST) Journal of Cardiac Failure. 11: 260-269. PMID 15880334 DOI: 10.1016/J.Cardfail.2005.03.009  0.352
2005 Packer M, McMurray J, Massie BM, Caspi A, Charlon V, Cohen-Solal A, Kiowski W, Kostuk W, Krum H, Levine B, Rizzon P, Soler J, Swedberg K, Anderson S, Demets DL. Clinical effects of endothelin receptor antagonism with bosentan in patients with severe chronic heart failure: results of a pilot study. Journal of Cardiac Failure. 11: 12-20. PMID 15704058 DOI: 10.1016/J.Cardfail.2004.05.006  0.315
2004 DeMets D, Califf R, Dixon D, Ellenberg S, Fleming T, Held P, Julian D, Kaplan R, Levine R, Neaton J, Packer M, Pocock S, Rockhold F, Seto B, Siegel J, et al. Issues in regulatory guidelines for data monitoring committees Clinical Trials (London, England). 1: 162-169. PMID 16281888 DOI: 10.1191/1740774504Cn019Xx  0.397
2004 DeMets DL, Fleming TR, Rockhold F, Massie B, Merchant T, Meisel A, Mishkin B, Wittes J, Stump D, Califf R. Liability issues for data monitoring committee members. Clinical Trials (London, England). 1: 525-31. PMID 16279293 DOI: 10.1191/1740774504Cn54Oa  0.348
2004 DeMets DL, Fleming TR. The independent statistician for data monitoring committees. Statistics in Medicine. 23: 1513-7. PMID 15122729 DOI: 10.1002/Sim.1786  0.431
2004 DeMets DL. Statistical issues in interpreting clinical trials Journal of Internal Medicine. 255: 529-537. PMID 15078496 DOI: 10.1111/J.1365-2796.2004.01320.X  0.433
2004 Chen YH, DeMets DL, Lan KK. Increasing the sample size when the unblinded interim result is promising. Statistics in Medicine. 23: 1023-38. PMID 15057876 DOI: 10.1002/Sim.1688  0.527
2004 Kosorok MR, Yuanjun S, DeMets DL. Design and analysis of group sequential clinical trials with multiple primary endpoints. Biometrics. 60: 134-45. PMID 15032783 DOI: 10.1111/J.0006-341X.2004.00146.X  0.4
2003 Califf RM, Morse MA, Wittes J, Goodman SN, Nelson DK, DeMets DL, Iafrate RP, Sugarman J. Toward protecting the safety of participants in clinical trials. Controlled Clinical Trials. 24: 256-71. PMID 12757992 DOI: 10.1016/S0197-2456(03)00005-9  0.374
2003 Chen YH, DeMets DL, Lan KK. Monitoring mortality at interim analyses while testing a composite endpoint at the final analysis. Controlled Clinical Trials. 24: 16-27. PMID 12559639 DOI: 10.1016/S0197-2456(02)00306-9  0.559
2002 Packer M, Fowler MB, Roecker EB, Coats AJ, Katus HA, Krum H, Mohacsi P, Rouleau JL, Tendera M, Staiger C, Holcslaw TL, Amann-Zalan I, DeMets DL. Effect of carvedilol on the morbidity of patients with severe chronic heart failure: results of the carvedilol prospective randomized cumulative survival (COPERNICUS) study. Circulation. 106: 2194-9. PMID 12390947 DOI: 10.1161/01.Cir.0000035653.72855.Bf  0.304
2002 Fleming TR, Ellenberg S, DeMets DL. Monitoring clinical trials: issues and controversies regarding confidentiality. Statistics in Medicine. 21: 2843-51. PMID 12325100 DOI: 10.1002/Sim.1288  0.43
2002 DeMets DL. Clinical trials in the new millennium. Statistics in Medicine. 21: 2779-87. PMID 12325093 DOI: 10.1002/Sim.1281  0.421
2002 Califf RM, DeMets DL. Principles from clinical trials relevant to clinical practice: Part II. Circulation. 106: 1172-5. PMID 12196347 DOI: 10.1161/01.Cir.0000023218.39412.32  0.392
2002 DeMets DL, Califf RM. Lessons learned from recent cardiovascular clinical trials: Part II. Circulation. 106: 880-6. PMID 12176964 DOI: 10.1161/01.Cir.0000023220.26465.89  0.376
2002 Lee JW, Jo SJ, Demets DL, Kim K. Confidence intervals following group sequential tests in clinical trials with multivariate observations Journal of Statistical Computation and Simulation. 72: 247-259. DOI: 10.1080/00949650212386  0.408
2001 De Gruttola VG, Clax P, DeMets DL, Downing GJ, Ellenberg SS, Friedman L, Gail MH, Prentice R, Wittes J, Zeger SL. Considerations in the evaluation of surrogate endpoints in clinical trials: Summary of a National Institutes of Health Workshop Controlled Clinical Trials. 22: 485-502. PMID 11578783 DOI: 10.1016/S0197-2456(01)00153-2  0.42
2001 Wedel H, Demets D, Deedwania P, Fagerberg B, Goldstein S, Gottlieb S, Hjalmarson A, Kjekshus J, Waagstein F, Wikstrand J. Challenges of subgroup analyses in multinational clinical trials: experiences from the MERIT-HF trial. American Heart Journal. 142: 502-11. PMID 11526365 DOI: 10.1067/Mhj.2001.117600  0.435
2001 O'Shea JC, DeMets DL. Statistical issues relating to international differences in clinical trials American Heart Journal. 142: 21-28. PMID 11431652 DOI: 10.1067/Mhj.2001.116275  0.395
2001 Packer M, Coats AJS, Fowler MB, Katus HA, Krum H, Mohacsi P, Rouleau JL, Tendera M, Castaigne A, Roecker EB, Schultz MK, DeMets DL. Effect of carvedilol on survival in severe chronic heart failure New England Journal of Medicine. 344: 1651-1658. PMID 11386263 DOI: 10.1056/Nejm200105313442201  0.354
2001 Fisher MR, Roecker EB, DeMets DL. The role of an independent statistical analysis center in the Industry-Modified National Institutes of Health Model Drug Information Journal. 35: 115-129. DOI: 10.1177/009286150103500113  0.421
2000 Spiessens B, Lesaffre E, Verbeke G, Kim K, DeMets DL. An overview of group sequential methods in longitudinal clinical trials Statistical Methods in Medical Research. 9: 497-515. PMID 11191262 DOI: 10.1177/096228020000900506  0.406
2000 Gong J, Pinheiro JC, Demets DL. Estimating significance level and power comparisons for testing multiple endpoints in clinical trials Controlled Clinical Trials. 21: 313-329. PMID 10913807 DOI: 10.1016/S0197-2456(00)00049-0  0.389
2000 Reboussin DM, Demets DL, Kim K, Lan KKG. Computations for group sequential boundaries using the Lan-DeMets spending function method Controlled Clinical Trials. 21: 190-207. PMID 10822118 DOI: 10.1016/S0197-2456(00)00057-X  0.377
2000 DeMets DL. Design of phase II trials in congestive heart failure American Heart Journal. 139. PMID 10740134 DOI: 10.1016/S0002-8703(00)90075-9  0.328
1999 DeMets DL. Statistics and ethics in medical research. Science and Engineering Ethics. 5: 97-117. PMID 11658016 DOI: 10.1007/S11948-999-0059-9  0.31
1999 DeMets DL, Pocock SJ, Julian DG. The agonising negative trend in monitoring of clinical trials Lancet. 354: 1983-1988. PMID 10622312 DOI: 10.1016/S0140-6736(99)03464-9  0.427
1998 Cohn JN, Goldstein SO, Greenberg BH, Lorell BH, Bourge RC, Jaski BE, Gottlieb SO, Mcgrew F, Demets DL, White BG. A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure New England Journal of Medicine. 339: 1810-1816. PMID 9854116 DOI: 10.1097/00132586-199910000-00011  0.316
1998 O'Connor CM, Carson PE, Miller AB, Pressler ML, Belkin RN, Neuberg GW, Frid DJ, Cropp AB, Anderson S, Wertheimer JH, DeMets DL. Effect of amlodipine on mode of death among patients with advanced heart failure in the PRAISE trial American Journal of Cardiology. 82: 881-887. PMID 9781971 DOI: 10.1016/S0002-9149(98)00496-2  0.325
1998 DeMets DL. Sequential Designs in Clinical Trials Cardiac Electrophysiology Review. 2: 57-60. DOI: 10.1023/A:1009954810211  0.354
1997 DeMets DL. Distinctions between fraud, bias, errors, misunderstanding, and incompetence Controlled Clinical Trials. 18: 637-650. PMID 9408726 DOI: 10.1016/S0197-2456(97)00010-X  0.381
1997 Pinheiro JC, Demets DL. Estimating and reducing bias in group sequential designs with Gaussian independent increment structure Biometrika. 84: 831-845. DOI: 10.1093/Biomet/84.4.831  0.304
1996 Fleming TR, DeMets DL. Surrogate End Points in Clinical Trials: Are We Being Misled? Annals of Internal Medicine. 125: 605-613. PMID 8815760 DOI: 10.7326/0003-4819-125-7-199610010-00011  0.39
1996 Packer M, O'Connor CM, Ghali JK, Pressler ML, Carson PE, Belkin RN, Miller AB, Neuberg GW, Frid D, Wertheimer JH, Cropp AB, Demets DL. Effect of amlodipine on morbidity and mortality in severe chronic heart failure New England Journal of Medicine. 335: 1107-1114. PMID 8813041 DOI: 10.1056/Nejm199610103351504  0.34
1996 Gange SJ, DeMets DL. Sequential monitoring of clinical trials with correlated responses Biometrika. 83: 157-167. DOI: 10.1093/Biomet/83.1.157  0.342
1995 DeMets DL, Fleming TR, Whitley RJ, Childress JF, Ellenberg SS, Foulkes M, Mayer KH, O'Fallon J, Pollard RB, Rahal JJ, Sande M, Straus S, Walters L, Whitley-Williams P. The Data and Safety Monitoring Board and Acquired immune deficiency syndrome (AIDS) clinical trials Controlled Clinical Trials. 16: 408-421. PMID 8720018 DOI: 10.1016/S0197-2456(95)00073-9  0.42
1995 Gange SJ, Linton KLP, Scott AJ, DeMets DL, Klein R. A comparison of methods for correlated ordinal measures with ophthalmic applications Statistics in Medicine. 14: 1961-1974. PMID 8677397 DOI: 10.1002/Sim.4780141803  0.317
1995 Jae Won Lee, DeMets DL. Group sequential comparison of changes: Ad-hoc versus more exact method Biometrics. 51: 21-30. PMID 7766776 DOI: 10.2307/2533311  0.33
1995 DeMets DL, Lan G. The alpha spending function approach to interim data analyses Cancer Treatment and Research. 75: 1-27. PMID 7640159 DOI: 10.1007/978-1-4615-2009-2_1  0.434
1995 Fleming TR, Neaton JD, Goldman A, DeMets DL, Launer C, Korvick J, Abrams D. Insights from monitoring the CPCRA didanosine/zalcitabine trial Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 10. PMID 7552519  0.307
1994 Furberg CD, Julian DG, Bigger JT, Breithardt G, Camm AJ, DeMets DL, Hallstrom A, Janse MJ, Lan KKG, Lazzara R, Marcus FI, Moss AJ, Tijssen JGP, Waldo AL, Pocock SJ, et al. The early termination of clinical trials: Causes, consequences, and control. With special reference to trials in the field of arrhythmias and sudden death Circulation. 89: 2892-2907. PMID 8205706 DOI: 10.1161/01.cir.89.6.2892  0.321
1994 Schwartz PJ, Furberg CD, Julian DG, Bigger JT, Breithardt G, Camm AJ, DeMets DL, Hallstrom A, Janse MJ, Lan KKG, Lazzara R, Marcus FI, Moss AJ, Tijssen JGP, Waldo AL, et al. The early termination of clinical trials: Causes, consequences, and control European Heart Journal. 15: 721-738. PMID 8088260  0.319
1994 DeMets DL, Lan KKG. Interim analysis: The alpha spending function approach Statistics in Medicine. 13: 1341-1352. PMID 7973215 DOI: 10.1002/Sim.4780131308  0.343
1994 Albert JM, Demets DL. On a model-based approach to estimating efficacy in clinical trials Statistics in Medicine. 13: 2323-2335. PMID 7855466 DOI: 10.1002/Sim.4780132204  0.37
1994 Lan KKG, Reboussin DM, Demets DL. Information and information fractions for design and sequential monitoring of clinical trials Communications in Statistics - Theory and Methods. 23: 403-420. DOI: 10.1080/03610929408831263  0.352
1993 Fleming TR, DeMets DL. Monitoring of clinical trials: Issues and recommendations Controlled Clinical Trials. 14: 183-197. PMID 8339549 DOI: 10.1016/0197-2456(93)90002-U  0.434
1992 Kim K, Demets DL. Sample size determination for group sequential clinical trials with immediate response Statistics in Medicine. 11: 1391-1399. PMID 1518999 DOI: 10.1002/Sim.4780111012  0.365
1992 Lee JW, DeMets DL. Sequential rank tests with repeated measurements in clinical trials Journal of the American Statistical Association. 87: 136-142. DOI: 10.1080/01621459.1992.10475184  0.301
1991 Demets DL, Newcomb PA, Carey P. Design issues for a breast cancer chemoprevention trial Preventive Medicine. 20: 101-108. PMID 2008419 DOI: 10.1016/0091-7435(91)90010-2  0.312
1991 Packer M, Carver JR, Rodeheffer RJ, Ivanhoe RJ, DiBianco R, Zeldis SM, Hendrix GH, Bommer WJ, Elkayam U, Kukin ML, Mallis GI, Sollano JA, Shannon J, Tandon PK, DeMets DL. Effect of oral milrinone on mortality in severe chronic heart failure New England Journal of Medicine. 325: 1468-1475. PMID 1944425 DOI: 10.1056/Nejm199111213252103  0.338
1991 Lin DY, Wei LJ, DeMets DL. Exact statistical inference for group sequential trials Biometrics. 47: 1399-1408. PMID 1786325 DOI: 10.2307/2532394  0.386
1991 Data Monitoring Board of the Physicians' Health Study, Cairns J, Cohen L, Colton T, DeMets DL, Deykin D, Friedman L, Greenwald P, Hutchison GB, Rosner B. Issues in the early termination of the aspirin component of the physicians' health study Annals of Epidemiology. 1: 395-405. PMID 1669520 DOI: 10.1016/1047-2797(91)90009-2  0.346
1991 Lee JW, DeMets DL. Sequential comparison of changes with repeated measurements data Journal of the American Statistical Association. 86: 757-762. DOI: 10.1080/01621459.1991.10475106  0.31
1990 Halperin M, DeMets DL, Ware JH. Early methodological developments for clinical trials at the National Heart, Lung and Blood Institute Statistics in Medicine. 9: 881-892. PMID 2218191 DOI: 10.1002/Sim.4780090804  0.434
1989 Lan KKG, DeMets DL. Changing frequency of interim analysis in sequential monitoring Biometrics. 45: 1017-1020. PMID 2790114 DOI: 10.2307/2531701  0.316
1987 Demets DL. Methods for combining randomized clinical trials: Strengths and limitations Statistics in Medicine. 6: 341-348. PMID 3616287 DOI: 10.1002/Sim.4780060325  0.404
1987 Williams GW, Snedecor SM, DeMets DL. Recruitment experience in the nocturnal oxygen therapy trial Controlled Clinical Trials. 8: 121-130. PMID 3440385 DOI: 10.1016/0197-2456(87)90015-8  0.37
1987 Kim K, DeMets DL. Confidence intervals following group sequential tests in clinical trials Biometrics. 43: 857-864. PMID 3427170 DOI: 10.2307/2531539  0.318
1987 Demets DL. Practical aspects in data monitoring: a brief review Statistics in Medicine. 6: 753-760. PMID 3321314 DOI: 10.1002/Sim.4780060706  0.433
1987 George SL, Friedman LM, Furberg CD, Demets DL. Fundamentals of Clinical Trials. (2nd ed.). Journal of the American Statistical Association. 82: 358. DOI: 10.2307/2289197  0.386
1987 Kim K, Demets DL. Design and analysis of group sequential tests based on the type I error spending rate function Biometrika. 74: 149-154. DOI: 10.1093/Biomet/74.1.149  0.312
1985 DeMets DL. Randomised controlled clinical trials: C.J. Bulpitt Martinus Nijhoff Publishers, The Hague, 1983, 261 pp., $52.00 Controlled Clinical Trials. 6: 244-245. DOI: 10.1016/0197-2456(85)90088-1  0.352
1984 Demets DL. Can early stopping procedures impact significantly on the efficiency of clinical trials without serious loss of information? Statistics in Medicine. 3: 445-451. PMID 6528138 DOI: 10.1002/Sim.4780030426  0.342
1984 DeMets DL, Hardy R, Friedman LM, Gordon Lan KK. Statistical aspects of early termination in the beta-blocker heart attack trial Controlled Clinical Trials. 5: 362-372. PMID 6151482 DOI: 10.1016/S0197-2456(84)80015-X  0.428
1984 DeMets DL. Stopping Guidelines Vs Stopping Rules: A Practitioner'S Point of View Communications in Statistics - Theory and Methods. 13: 2395-2417. DOI: 10.1080/03610928408828833  0.374
1984 DeMets DL, Gordon Lan KK. An overview of sequential methods and their application in clinical trials Communications in Statistics - Theory and Methods. 13: 2315-2338. DOI: 10.1080/03610928408828829  0.317
1982 Halperin M, Lan KK, Ware JH, Johnson NJ, DeMets DL. An aid to data monitoring in long-term clinical trials. Controlled Clinical Trials. 3: 311-23. PMID 7160189 DOI: 10.1016/0197-2456(82)90022-8  0.409
1982 Demets DL, Ware JH. Asymmetric group sequential boundaries for monitoring clinical trials Biometrika. 69: 661-663. DOI: 10.1093/Biomet/69.3.661  0.372
1982 DeMets D, Hardy R, Friedman L, Lan G. Aspects of early termination in the beta-blocker heart attack trial Controlled Clinical Trials. 3: 135. DOI: 10.1016/0197-2456(82)90041-1  0.317
1981 May GS, DeMets DL, Friedman LM, Furberg C, Passamani E. The randomized clinical trial: Bias in analysis Circulation. 64: 669-673. PMID 7023743 DOI: 10.1161/01.Cir.64.4.669  0.441
1981 Howard JM, DeMets D. How informed is informed consent?: The BHAT experience Controlled Clinical Trials. 2: 287-303. PMID 6120794 DOI: 10.1016/0197-2456(81)90019-2  0.34
1981 Friedman L, DeMets D. The data monitoring committee: how it operates and why. Irb: Ethics & Human Research. 3: 6-8. DOI: 10.2307/3563613  0.37
1980 Wu M, Fisher M, DeMets D. Sample sizes for long-term medical trial with time-dependent dropout and event rates Controlled Clinical Trials. 1: 111-124. PMID 7261605 DOI: 10.1016/0197-2456(80)90014-8  0.354
1980 Demets DL, Ware JH. Group sequential methods for clinical trials with a one-sided hypothesis Biometrika. 67: 651-660. DOI: 10.1093/Biomet/67.3.651  0.404
1976 Henkin RI, Schecter PJ, Friedewald WT, Demets DL, Raff M. A double blind study of the effects of zinc sulfate on taste and smell dysfunction American Journal of the Medical Sciences. 272: 285-299. PMID 797259 DOI: 10.1097/00000441-197611000-00006  0.301
1976 Byar DP, Simon RM, Friedewald WT, Schlesselman JJ, DeMets DL, Ellenberg JH, Gail MH, Ware JH. Randomized clinical trials. Perspectives on some recent ideas New England Journal of Medicine. 295: 74-80. PMID 775331 DOI: 10.1056/Nejm197607082950204  0.433
Low-probability matches (unlikely to be authored by this person)
2006 Begg CB, Brawley O, Califf RM, Demets DL, Ellenberg SS, Kaplan RS. Marketing drugs too early in testing. Science (New York, N.Y.). 312: 195. PMID 16614197 DOI: 10.1126/Science.312.5771.195C  0.3
2010 Hennekens CH, Schneider WR, Pokov A, Hetzel S, Demets D, Serebruany V, Schröder H. A randomized trial of aspirin at clinically relevant doses and nitric oxide formation in humans. Journal of Cardiovascular Pharmacology and Therapeutics. 15: 344-8. PMID 20938039 DOI: 10.1177/1074248410375091  0.299
1996 Freedman L, Anderson G, Kipnis V, Prentice R, Wang CY, Rossouw J, Wittes J, DeMets D. Approaches to monitoring the results of long-term disease prevention trials: Examples from the Women's Health Initiative Controlled Clinical Trials. 17: 509-525. PMID 8974210 DOI: 10.1016/S0197-2456(96)00016-5  0.299
2013 Jacobs AK, Kushner FG, Ettinger SM, Guyton RA, Anderson JL, Ohman EM, Albert NM, Antman EM, Arnett DK, Bertolet M, Bhatt DL, Brindis RG, Creager MA, DeMets DL, Dickersin K, et al. ACCF/AHA clinical practice guideline methodology summit report: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 127: 268-310. PMID 23230312 DOI: 10.1161/Cir.0B013E31827E8E5F  0.299
2023 DeMets DL, Zarin DA, Rockhold F, Ellenberg SS, Fleming T, Wittes J. Bringing data monitoring committee charters into the sunlight. Clinical Trials (London, England). 17407745231169499. PMID 37231737 DOI: 10.1177/17407745231169499  0.298
2019 McMurray JJV, Solomon SD, Inzucchi SE, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Anand IS, Bělohlávek J, Böhm M, Chiang CE, Chopra VK, de Boer RA, Desai AS, ... ... DeMets DL, et al. Dapagliflozin in Patients with Heart Failure and Reduced Ejection Fraction. The New England Journal of Medicine. PMID 31535829 DOI: 10.1056/Nejmoa1911303  0.298
1989 Lan KKG, Demets DL. Group sequential procedures: Calendar versus information time Statistics in Medicine. 8: 1191-1198. PMID 2814068 DOI: 10.1002/Sim.4780081003  0.297
2019 Shamoun F, De Marco T, DeMets D, Mei C, Lindenfeld J, Saxon LA, Boehmer JP, Leigh J, Yong P, Feldman AM, Bristow MR. Impact of Degree of Left Ventricular Remodeling on Clinical Outcomes From Cardiac Resynchronization Therapy. Jacc. Heart Failure. PMID 30738980 DOI: 10.1016/J.Jchf.2018.11.004  0.297
1983 Gordon Lan KK, Demets DL. Discrete sequential boundaries for clinical trials Biometrika. 70: 659-663. DOI: 10.1093/Biomet/70.3.659  0.292
1990 DeMets DL. Methodological issues in AIDS clinical trials. Data monitoring and sequential analysis--an academic perspective Journal of Acquired Immune Deficiency Syndromes. 3. PMID 2231293  0.291
2014 Fleming TR, Hennekens CH, Pfeffer MA, Demets DL. Enhancing trial integrity by protecting the independence of data monitoring committees in clinical trials Journal of Biopharmaceutical Statistics. 24: 968-975. DOI: 10.1080/10543406.2014.925719  0.29
2010 Joshua Chen YH, Demets DL, Gordon Lan KK. Some drop-the-loser designs for monitoring multiple doses. Statistics in Medicine. 29: 1793-807. PMID 20658548 DOI: 10.1002/Sim.3958  0.29
2022 Sandercock PAG, Darbyshire J, DeMets D, Fowler R, Lalloo DG, Munavvar M, Staplin N, Warris A, Wittes J, Emberson JR. Experiences of the Data Monitoring Committee for the RECOVERY trial, a large-scale adaptive platform randomised trial of treatments for patients hospitalised with COVID-19. Trials. 23: 881. PMID 36258219 DOI: 10.1186/s13063-022-06824-6  0.288
2018 Kalscheur MM, Kipp RT, Tattersall MC, Mei C, Buhr KA, DeMets DL, Field ME, Eckhardt LL, Page CD. Machine Learning Algorithm Predicts Cardiac Resynchronization Therapy Outcomes: Lessons From the COMPANION Trial. Circulation. Arrhythmia and Electrophysiology. 11: e005499. PMID 29326129 DOI: 10.1161/Circep.117.005499  0.287
1988 Klein R, Klein BEK, Moss SE, Davis MD, Demets DL. Glycosylated Hemoglobin Predicts the Incidence and Progression of Diabetic Retinopathy Jama: the Journal of the American Medical Association. 260: 2864-2871. PMID 3184351 DOI: 10.1001/Jama.1988.03410190112033  0.286
2003 Liu G, Oettel K, Bailey H, Ummersen LV, Tutsch K, Staab MJ, Horvath D, Alberti D, Arzoomanian R, Rezazadeh H, McGovern J, Robinson E, DeMets D, Wilding G. Phase II trial of perillyl alcohol (NSC 641066) administered daily in patients with metastatic androgen independent prostate cancer. Investigational New Drugs. 21: 367-72. PMID 14578686 DOI: 10.1023/A:1025437115182  0.284
2004 Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, De Marco T, Carson P, DiCarlo L, DeMets D, White BG, DeVries DW, Feldman AM. Cardiac-resynchronization therapy with or without an implantable defibrillator in advanced chronic heart failure. The New England Journal of Medicine. 350: 2140-50. PMID 15152059 DOI: 10.1056/Nejmoa032423  0.282
2010 Carson PE, Zile M, McMurray J, McKelvie R, Komajda M, Hetzel S, DeMets D, Staiger C, Ptaszynska A, Massie B. Heart Failure With Preserved Ejection Fraction: Mortality Risk Post First Hospitalization - Data From I-Preserve Journal of the American College of Cardiology. 55. DOI: 10.1016/S0735-1097(10)61322-8  0.281
2006 Antman EM, DeMets D, Loscalzo J. Cyclooxygenase inhibition and cardiovascular risk. Circulation. 112: 759-70. PMID 16061757 DOI: 10.1161/Circulationaha.105.568451  0.281
2000 DeMets DL. The role of surrogate outcome measures in evaluating medical devices Surgery. 128: 379-385. PMID 10965307 DOI: 10.1067/Msy.2000.107064  0.278
1999 Lee JW, Demets DL. Estimation following group sequential tests with repeated measurements data Computational Statistics and Data Analysis. 32: 69-77. DOI: 10.1016/S0167-9473(99)00021-3  0.278
1994 Demets DL, Anbar D, Fairweather W, Louis TA, O’Neill RT. Training the next generation of biostatisticians American Statistician. 48: 280-284. DOI: 10.1080/00031305.1994.10476080  0.276
2022 Solomon SD, Vaduganathan M, Claggett BL, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Belohlavek J, Chiang CE, Willem Borleffs CJ, Comin-Colet J, et al. Baseline Characteristics of Patients With HF With Mildly Reduced and Preserved Ejection Fraction: DELIVER Trial. Jacc. Heart Failure. 10: 184-197. PMID 35241246 DOI: 10.1016/j.jchf.2021.11.006  0.275
2014 Nishimura RA, Otto CM, Bonow RO, Carabello BA, Erwin JP, Guyton RA, O'Gara PT, Ruiz CE, Skubas NJ, Sorajja P, Sundt TM, Thomas JD, Anderson JL, Halperin JL, Albert NM, ... ... DeMets D, et al. 2014 AHA/ACC guideline for the management of patients with valvular heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. The Journal of Thoracic and Cardiovascular Surgery. 148: e1-e132. PMID 24939033 DOI: 10.1016/J.Jtcvs.2014.05.014  0.275
1989 Klein R, Moss SE, Klein BEK, Davis MD, DeMets DL. The Wisconsin epidemiology study of diabetic retinopathy. XI. The incidence of macular edema Ophthalmology. 96: 1501-1510. PMID 2587045 DOI: 10.1016/S0161-6420(89)32699-6  0.274
1989 Klein R, Moss SE, Klein BEK, DeMets DL. Relation of Ocular and Systemic Factors to Survival in Diabetes Archives of Internal Medicine. 149: 266-272. PMID 2916872 DOI: 10.1001/Archinte.1989.00390020016004  0.273
2017 Yetley EA, DeMets DL, Harlan WR. Surrogate disease markers as substitutes for chronic disease outcomes in studies of diet and chronic disease relations. The American Journal of Clinical Nutrition. PMID 29021287 DOI: 10.3945/Ajcn.117.164046  0.273
1996 Reboussin DM, DeMets DL. Exact permutation inference for two sample repeated measures data Communications in Statistics-Theory and Methods. 25: 2223-2238. DOI: 10.1080/03610929608831834  0.273
2015 Fihn SD, Blankenship JC, Alexander KP, Bittl JA, Byrne JG, Fletcher BJ, Fonarow GC, Lange RA, Levine GN, Maddox TM, Naidu SS, Ohman EM, Smith PK, Anderson JL, Halperin JL, ... ... DeMets D, et al. 2014 ACC/AHA/AATS/PCNA/SCAI/STS focused update of the guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines, and the American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. The Journal of Thoracic and Cardiovascular Surgery. 149: e5-23. PMID 25827388 DOI: 10.1016/J.Jtcvs.2014.11.002  0.271
2016 DeMets DL, Fleming TR, Geller G, Ransohoff DF. Institutional Responsibility and the Flawed Genomic Biomarkers at Duke University: A Missed Opportunity for Transparency and Accountability. Science and Engineering Ethics. PMID 27882502 DOI: 10.1007/S11948-016-9844-4  0.27
2012 Tracy CM, Epstein AE, Darbar D, DiMarco JP, Dunbar SB, Estes NA, Ferguson TB, Hammill SC, Karasik PE, Link MS, Marine JE, Schoenfeld MH, Shanker AJ, Silka MJ, ... ... DeMets D, et al. 2012 ACCF/AHA/HRS focused update of the 2008 guidelines for device-based therapy of cardiac rhythm abnormalities: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. The Journal of Thoracic and Cardiovascular Surgery. 144: e127-45. PMID 23140976 DOI: 10.1016/J.Jtcvs.2012.08.032  0.269
2021 DeMets DL, Wittes J. Data monitoring committee interim reports: We must get there soon! Clinical Trials (London, England). 19: 107-111. PMID 34693741 DOI: 10.1177/17407745211051279  0.269
1989 Klein R, Klein BEK, Moss SE, Davis MD, Demets DL. The Wisconsin Epidemiologic Study of Diabetic Retinopathy: X. Four-Year Incidence and Progression of Diabetic Retinopathy when Age at Diagnosis is 30 Years or More Archives of Ophthalmology. 107: 244-249. PMID 2644929 DOI: 10.1001/Archopht.1989.01070010250031  0.268
1985 DeMets DL, Gail MH. Use of logrank tests and group sequential methods at fixed calendar times Biometrics. 41: 1039-1044. PMID 4096915 DOI: 10.2307/2530975  0.268
2024 Fleming TR, Wittes J, Fiuzat M, Bristow MR, Rockhold FW, Connor JT, Saville BR, Claggett B, Cavagna I, Abraham WT, Cook TD, Lindenfeld J, O'Connor C, DeMets DL. Training the Next Generation of Data Monitoring Committee Members: An Initiative of the Heart Failure Collaboratory. Jacc. Heart Failure. PMID 38530701 DOI: 10.1016/j.jchf.2024.02.016  0.267
2004 Fan XF, DeMets DL, Lan KK. Conditional bias of point estimates following a group sequential test. Journal of Biopharmaceutical Statistics. 14: 505-30. PMID 15206542 DOI: 10.1081/Bip-120037195  0.267
1983 Klein R, Klein BEK, Moss SE, DeMets D. Inter-observer variation in refraction and visual acuity measurement using a standardized protocol. Ophthalmology. 90: 1357-1359. PMID 6664675 DOI: 10.1016/S0161-6420(83)34382-7  0.264
1990 Sitter RR, Hanrahan LP, Demets D, Anderson HA. A monitoring system to detect increased rates of cancer incidence. American Journal of Epidemiology. 132: S123-30. PMID 2356823 DOI: 10.1093/Oxfordjournals.Aje.A115773  0.264
1988 Klein R, Klein BEK, Moss S, Demets DL. Proteinuria in Diabetes Archives of Internal Medicine. 148: 181-186. PMID 3337593 DOI: 10.1001/Archinte.1988.00380010183019  0.263
2013 Anderson JL, Adams CD, Antman EM, Bridges CR, Califf RM, Casey DE, Chavey WE, Fesmire FM, Hochman JS, Levin TN, Lincoff AM, Peterson ED, Theroux P, Wenger NK, Wright RS, ... ... DeMets D, et al. 2012 ACCF/AHA focused update incorporated into the ACCF/AHA 2007 guidelines for the management of patients with unstable angina/non-ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology. 61: e179-347. PMID 23639841 DOI: 10.1016/J.Jacc.2013.01.014  0.262
1984 Klein R, Klein BEK, Moss SE, Davis MD, DeMets DL. The Wisconsin epidemiologic study of diabetic retinopathy. IV. Diabetic macular edema Ophthalmology. 91: 1464-1474. PMID 6521986 DOI: 10.1016/S0161-6420(84)34102-1  0.26
1989 Klein R, Klein BEK, Moss SE, Davis MD, Demets DL. The Wisconsin Epidemiologic Study of Diabetic Retinopathy: Ix. Four-Year Incidence and Progression of Diabetic Retinopathy when Age at Diagnosis is Less than 30 Years Archives of Ophthalmology. 107: 237-243. PMID 2916977 DOI: 10.1001/Archopht.1989.01070010243030  0.26
2001 DeMets DL, Yusuf S. The Data and Safety Monitoring Committee: Some final thoughts American Heart Journal. 141: 548-549. PMID 11275918 DOI: 10.1067/Mhj.2001.113837  0.258
2013 Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Guyton RA, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK. Management of patients with peripheral artery disease (compilation of 2005 and 2011 ACCF/AHA guideline recommendations): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 127: 1425-43. PMID 23457117 DOI: 10.1161/Cir.0B013E31828B82Aa  0.258
2004 DeMets DL. Principles of Data and Safety Monitoring Boards in Randomized Trials Clinical Trials in Heart Disease: a Companion to Braunwald's Heart Disease: Second Edition. 22-32. DOI: 10.1016/B978-0-7216-0408-4.50009-3  0.257
2014 Hennekens CH, DeMets DL. Prevention: Aspirin in primary prevention needs individual judgements. Nature Reviews. Cardiology. 11: 438-40. PMID 24958081 DOI: 10.1038/Nrcardio.2014.88  0.257
2018 Vardeny O, Udell JA, Joseph J, Farkouh ME, Hernandez AF, McGeer AJ, Talbot HK, Bhatt DL, Cannon CP, Goodman SG, Anand I, DeMets DL, Temte J, Wittes J, Nichol K, et al. High-dose influenza vaccine to reduce clinical outcomes in high-risk cardiovascular patients: Rationale and design of the INVESTED trial. American Heart Journal. 202: 97-103. PMID 29909156 DOI: 10.1016/J.Ahj.2018.05.007  0.257
2006 Demets DL, Hennekens CH. Data monitoring for the aspirin component of the Physicians' Health Study: Issues in early termination for a major secondary endpoint Data Monitoring in Clinical Trials: a Case Studies Approach. 73-84. DOI: 10.1007/0-387-30107-0_7  0.256
2002 Love RR, Duc NB, Allred DC, Binh NC, Dinh NV, Kha NN, Thuan TV, Mohsin SK, Roanh le D, Khang HX, Tran TL, Quy TT, Thuy NV, Thé PN, Cau TT, ... ... DeMets DL, et al. Oophorectomy and tamoxifen adjuvant therapy in premenopausal Vietnamese and Chinese women with operable breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 20: 2559-66. PMID 12011136 DOI: 10.1200/Jco.2002.08.169  0.255
1982 DeMets DL, Williams GW, Brown BW. A case report of data monitoring experience: The nocturnal oxygen therapy trial Controlled Clinical Trials. 3: 113-124. PMID 6749425 DOI: 10.1016/0197-2456(82)90039-3  0.254
2013 Jacobs AK, Kushner FG, Ettinger SM, Guyton RA, Anderson JL, Ohman EM, Albert NM, Antman EM, Arnett DK, Bertolet M, Bhatt DL, Brindis RG, Creager MA, DeMets DL, Dickersin K, et al. ACCF/AHA clinical practice guideline methodology summit report: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology. 61: 213-65. PMID 23238451 DOI: 10.1016/J.Jacc.2012.09.025  0.254
1989 Wiley AL, Wirtanen GW, Stephenson JA, Ramirez G, Demets D, Lee JW. Combined hepatic artery 5‐fluorouracil and irradiation of liver metastases. A randomized study Cancer. 64: 1783-1789. PMID 2790692 DOI: 10.1002/1097-0142(19891101)64:9<1783::Aid-Cncr2820640904>3.0.Co;2-Q  0.254
1984 Klein R, Klein BEK, Moss SE, Davis MD, Demets DL. The Wisconsin Epidemiologic Study of Diabetic Retinopathy: II. Prevalence and Risk of Diabetic Retinopathy When Age at Diagnosis is Less than 30 Years Archives of Ophthalmology. 102: 520-526. PMID 6367724 DOI: 10.1001/Archopht.1984.01040030398010  0.252
1988 Klein R, Moss SE, Klein BEK, Davis MD, DeMets DL. The Wisconsin epidemiologic study of diabetic retinopathy: VIII. The incidence of retinal photocoagulation Journal of Diabetic Complications. 2: 79-87. PMID 2971076 DOI: 10.1016/0891-6632(88)90008-6  0.251
1985 Klein R, Davis MD, Moss SE, Klein BE, DeMets DL. The Wisconsin Epidemiologic Study of Diabetic Retinopathy. A comparison of retinopathy in younger and older onset diabetic persons Advances in Experimental Medicine and Biology. 189: 321-335. PMID 4036719 DOI: 10.1007/978-1-4757-1850-8_18  0.25
2006 Friedman LM, Demets DL, Hardy R. Data and safety monitoring in the Beta-Blocker Heart Attack Trial: Early experience in formal monitoring methods Data Monitoring in Clinical Trials: a Case Studies Approach. 64-72. DOI: 10.1007/0-387-30107-0_6  0.25
2022 DeMets DL, Fleming TR, Ellenberg SS. Monitoring clinical trials in infectious diseases. Journal of Allergy and Infectious Diseases. 2: 29-32. PMID 35005713 DOI: 10.46439/allergy.2.019  0.25
2003 Love RR, Duc NB, Havighurst TC, Mohsin SK, Zhang Q, DeMets DL, Allred DC. Her-2/neu overexpression and response to oophorectomy plus tamoxifen adjuvant therapy in estrogen receptor-positive premenopausal women with operable breast cancer. Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. 21: 453-7. PMID 12560434 DOI: 10.1200/Jco.2003.10.133  0.25
1985 Klein R, Klein BEK, Moss SE, Davis MD, DeMets DL. Retinopathy in young-onset diabetic patients Diabetes Care. 8: 311-315. PMID 4042795 DOI: 10.2337/Diacare.8.4.311  0.25
1976 Ware JH, Demets DL. Reanalysis of some baboon descent data Biometrics. 32: 459-463. PMID 953142 DOI: 10.2307/2529516  0.249
1984 Klein R, Klein BEK, Moss SE, Davis MD, Demets DL. The Wisconsin Epidemiologic Study of Diabetic Retinopathy: III. Prevalence and Risk of Diabetic Retinopathy When Age at Diagnosis is 30 or More Years Archives of Ophthalmology. 102: 527-532. PMID 6367725 DOI: 10.1001/Archopht.1984.01040030405011  0.249
2022 Molnar A, Lau S, Berges M, Masa RB, Solano JJ, Alter SM, Clayton LM, Shih RD, DeMets DL, Maki DG, Hennekens CH. Ivermectin in COVID-19: The Case for a Moratorium on Prescriptions. Therapeutic Innovation & Regulatory Science. PMID 35147927 DOI: 10.1007/s43441-022-00378-0  0.249
2018 Foster JG, Wood SK, Pfeffer MA, DeMets DL, Garber A, Hennekens CH. ASPIRIN FOR PRIMARY PREVENTION IN PATIENTS WITH TYPE 2 DIABETES. Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists. PMID 29975578 DOI: 10.4158/Ep-2018-0073  0.248
1986 Klein R, Klein BEK, Moss SE, Demets DL. The Validity Of A Survey Question To Study Diabetic Retinopathy American Journal of Epidemiology. 124: 104-110. PMID 3717132 DOI: 10.1093/Oxfordjournals.Aje.A114353  0.248
2011 Hennekens CH, DeMets D. Statistical Association and Causation: Contributions of Different Types of Evidence Jama. 305: 1134-1135. PMID 21406653 DOI: 10.1001/Jama.2011.322  0.248
2002 Love RR, Duc NB, Dinh NV, Shen T, Havighurst TC, Allred DC, DeMets DL. Re: Mastectomy and Oophorectomy by Menstrual Cycle Phase in Women With Operable Breast Cancer Journal of the National Cancer Institute. 94: 662-669. PMID 12441328 DOI: 10.1093/Jnci/94.22.1719  0.248
1989 Klein R, Klein BEK, Moss SE, Davis MD, DeMets DL. Is blood pressure a predictor of the incidence or progression of diabetic retinopathy? Archives of Internal Medicine. 149: 2427-2432. PMID 2684072 DOI: 10.1001/Archinte.1989.00390110033008  0.247
1985 Klein R, Klein BEK, Moss SE, Demets DL. Blood pressure and hypertension in diabetes American Journal of Epidemiology. 122: 75-89. PMID 4014203 DOI: 10.1093/Oxfordjournals.Aje.A114088  0.247
1998 Demets DL, Woolson R, Brooks C, Qu R. Where the Jobs Are: A Study of Amstat News Job Advertisements American Statistician. 52: 303-307. DOI: 10.1080/00031305.1998.10480586  0.247
2022 Vardeny O, Fang JC, Desai AS, Jhund PS, Claggett B, Vaduganathan M, de Boer RA, Hernandez AF, Lam CSP, Inzucchi SE, Martinez FA, Kosiborod MN, DeMets D, O'Meara E, Zieroth S, et al. Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial. Nature Medicine. PMID 36522606 DOI: 10.1038/s41591-022-02102-9  0.246
2019 DeMets DL, Cook TD. Alternatives to Intention-to-Treat Analyses-Reply. Jama. 321: 2135. PMID 31162566 DOI: 10.1001/Jama.2019.3096  0.246
1990 Love RR, Newcomb PA, Wiebe DA, Surawicz TS, Jordan VC, Carbone PP, Demets DL. Effects of tamoxifen therapy on lipid and lipoprotein levels in postmenopausal patients with node-negative breast cancer Journal of the National Cancer Institute. 82: 1327-1332. PMID 2199681 DOI: 10.1093/Jnci/82.16.1327  0.246
2020 Docherty K, Inzucchi SE, Kosiborod MN, Kober L, Langkilde AM, Martinez F, Bengtsson O, Demets DL, Sjöstrand M, Sabatine MS, Solomon S, Jhund P, Mcmurray JJ. 1112-P: Does Background T2D Therapy Modify the Benefits of Dapagliflozin in Heart Failure? Analysis of the DAPA-HF Trial Diabetes. 69. DOI: 10.2337/Db20-1112-P  0.246
2002 Califf RM, DeMets DL. Principles from clinical trials relevant to clinical practice: Part I. Circulation. 106: 1015-21. PMID 12186809 DOI: 10.1161/01.CIR.0000023260.78078.BB  0.245
1987 Klein R, Klein BEK, Moss SE, Davis MD, DeMets DL. The Wisconsin epidemiologic study of diabetic retinopathy. VII. Diabetic nonproliferative retinal lesions Ophthalmology. 94: 1389-1400. PMID 3500443 DOI: 10.1016/S0161-6420(87)33275-0  0.245
2000 DeMets DL. Relationships between data monitoring committees Controlled Clinical Trials. 21: 54-55. DOI: 10.1016/S0197-2456(99)00048-3  0.242
2019 Robishaw JD, DeMets DL, Wood SK, Boiselle PM, Hennekens CH. Establishing and Maintaining Research Integrity at Academic Institutions: Challenges and Opportunities. The American Journal of Medicine. PMID 31520622 DOI: 10.1016/J.Amjmed.2019.08.036  0.241
1984 Klein R, Klein BEK, Moss SE, Demets DL, Kaufman I, Voss PS. Prevalence of diabetes mellitus in Southern Wisconsin American Journal of Epidemiology. 119: 54-61. PMID 6691336 DOI: 10.1093/Oxfordjournals.Aje.A113725  0.24
2006 Demets DL, Williams GW, Brown BW. The Nocturnal Oxygen Therapy Trial data monitoring experience: Problem with reporting lags Data Monitoring in Clinical Trials: a Case Studies Approach. 292-301. DOI: 10.1007/0-387-30107-0_28  0.24
2017 DeMets DL, Cook TD, Buhr KA. Guidelines for Statistical Analysis Plans. Jama. 318: 2301-2303. PMID 29260205 DOI: 10.1001/Jama.2017.18954  0.24
1977 DeMets D, Halperin M. Estimation of a Simple Regression Coefficient in Samples Arising from a Sub-Sampling Procedure Biometrics. 33: 47. DOI: 10.2307/2529302  0.238
1987 Klein R, Klein BEK, Moss SE, Davis MD, DeMets DL. The Wisconsin epidemiologic study of diabetic retinopathy. VI. Retinal photocoagulation +a Ophthalmology. 94: 747-753. PMID 3658346 DOI: 10.1016/S0161-6420(87)33525-0  0.236
1982 DeMets DL, Halperin M. Early stopping in the two-sample problem for bounded random variables Controlled Clinical Trials. 3: 1-11. PMID 7067469 DOI: 10.1016/0197-2456(82)90015-0  0.234
1977 Klein HG, Aledort LM, Bouma BN, Hoyer LW, Zimmerman TS, DeMets DL. A Cooperative Study for the Detection of the Carrier State of Classic Hemophilia The New England Journal of Medicine. 296: 959-962. PMID 846542 DOI: 10.1056/Nejm197704282961702  0.234
2020 Gitin A, Pfeffer MA, DeMets DL, Hennekens CH. ASPIRIN IN PRIMARY PREVENTION: NEEDS INDIVIDUAL JUDGMENTS. The American Journal of Medicine. PMID 32017893 DOI: 10.1016/J.Amjmed.2020.01.006  0.232
2020 Inzucchi SE, Docherty K, Kober L, Kosiborod MN, Martinez F, Ponikowski P, Sabatine MS, Solomon S, Belohlavek J, Böhm M, Chiang C, Boer RAD, Diez M, Dukat A, Ljungman CEA, ... ... Demets DL, et al. 271-OR: ADA Presidents’ Select Abstract: Effect of Dapagliflozin on the Incidence of Diabetes: A Prespecified Exploratory Analysis from DAPA-HF Diabetes. 69. DOI: 10.2337/Db20-271-Or  0.23
1991 Love RR, Wiebe DA, Newcomb PA, Cameron L, Leventhal H, Jordan VC, Feyzi J, DeMets DL. Effects of tamoxifen on cardiovascular risk factors in postmenopausal women. Annals of Internal Medicine. 115: 860-4. PMID 1952472 DOI: 10.7326/0003-4819-115-11-860  0.23
2005 DeMets DL. Discussion on "statistical issues arising in the Women's Health Initiative" Biometrics. 61: 914-918. DOI: 10.1111/J.0006-341X.2005.454_4.X  0.23
2023 Vardeny O, Fang JC, Desai AS, Jhund PS, Claggett B, Vaduganathan M, de Boer RA, Hernandez AF, Lam CSP, Inzucchi SE, Martinez FA, Kosiborod MN, DeMets D, O'Meara E, Zieroth S, et al. Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial. Nature Medicine. PMID 36932245 DOI: 10.1038/s41591-023-02302-x  0.229
1990 Klein R, Moss SE, Klein BEK, Davis MD, DeMets DL. Wisconsin epidemiologic study of diabetic retinopathy: XII. Relationship of C-peptide and diabetic retinopathy Diabetes. 39: 1445-1450. PMID 2121570 DOI: 10.2337/Diab.39.11.1445  0.225
2018 DeMets DL, Cook T. Challenges of Non-Intention-to-Treat Analyses. Jama. PMID 30556836 DOI: 10.1001/Jama.2018.19192  0.225
1984 Gordon Lan KK, DeMets DL, Halperin M. More flexible sequential and non-sequential designs in long-term clinnical trials Communications in Statistics - Theory and Methods. 13: 2339-2353. DOI: 10.1080/03610928408828830  0.224
2006 DeMets DL, Stormo G, Boehnke M, Louis TA, Taylor J, Dixon D. Training of the next generation of biostatisticians: a call to action in the U.S. Statistics in Medicine. 25: 3415-29. PMID 16927449 DOI: 10.1002/Sim.2668  0.221
2000 DeMets DL. Patient-specific dosing of IIb/IIIa antagonists during acute coronary syndromes: Rationale and design of the PARAGON B study American Heart Journal. 139: 563-566. DOI: 10.1067/Mhj.2000.105301  0.219
1991 Love RR, Newcomb PA, Wiebe DA, Surawicz TS, Jordan VC, Carbone PP, DeMets DL. 90244353 Effects of tamoxifen therapy on lipid and lipoprotein levels in postmenopausal patients with node-negative breast cancer Maturitas. 13: 163-164. DOI: 10.1016/0378-5122(91)90101-U  0.216
2002 DeMets DL, Califf RM. Lessons learned from recent cardiovascular clinical trials: Part I. Circulation. 106: 746-51. PMID 12163438 DOI: 10.1161/01.CIR.0000023219.51483.66  0.215
2020 DeMets DL, Psaty BM, Fleming TR. When Can Intermediate Outcomes Be Used as Surrogate Outcomes? Jama. PMID 32105291 DOI: 10.1001/Jama.2020.1176  0.213
2017 Fleming TR, Demets DL, McShane LM. Discussion: The role, position, and function of the FDA-The past, present, and future. Biostatistics (Oxford, England). PMID 28633307 DOI: 10.1093/Biostatistics/Kxx023  0.213
2022 Jhund PS, Kondo T, Butt JH, Docherty KF, Claggett BL, Desai AS, Vaduganathan M, Gasparyan SB, Bengtsson O, Lindholm D, Petersson M, Langkilde AM, de Boer RA, DeMets D, Hernandez AF, et al. Dapagliflozin across the range of ejection fraction in patients with heart failure: a patient-level, pooled meta-analysis of DAPA-HF and DELIVER. Nature Medicine. PMID 36030328 DOI: 10.1038/s41591-022-01971-4  0.212
2006 Demets DL, Friedman LM. The data monitoring experience in the Cardiac Arrhythmia Suppression Trial: The need to be prepared early Data Monitoring in Clinical Trials: a Case Studies Approach. 198-208. DOI: 10.1007/0-387-30107-0_18  0.212
2002 Love RR, Allred DC, DeMets DL. Re: The influence of menstrual cycle phase on surgical treatment of primary breast cancer: have we made any progress over the past 13 years? Journal of the National Cancer Institute. 94: 1722-3; author reply. PMID 12441332 DOI: 10.1093/Jnci/94.22.1722  0.212
2003 Levin B, Ellenberg SS, Fleming TR, DeMets DL. No, Not Another IRB Irb: Ethics & Human Research. 25: 17. DOI: 10.2307/3564409  0.208
2022 Peikert A, Martinez FA, Vaduganathan M, Claggett BL, Kulac IJ, Desai AS, Jhund PS, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Shah SJ, Katova T, et al. Efficacy and Safety of Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction According to Age: The DELIVER Trial. Circulation. Heart Failure. PMID 36029467 DOI: 10.1161/CIRCHEARTFAILURE.122.010080  0.205
2021 Rossing P, Inzucchi SE, Vart P, Jongs N, Docherty KF, Jhund PS, Køber L, Kosiborod MN, Martinez FA, Ponikowski P, Sabatine MS, Solomon SD, DeMets DL, Bengtsson O, Lindberg M, et al. Dapagliflozin and new-onset type 2 diabetes in patients with chronic kidney disease or heart failure: pooled analysis of the DAPA-CKD and DAPA-HF trials. The Lancet. Diabetes & Endocrinology. PMID 34856173 DOI: 10.1016/S2213-8587(21)00295-3  0.203
1994 Demets DL. Fraud and misconduct in medical research. Stephen Lock and Frank Wells (eds), London, British Medical Journal, 1993. no. of pages: XI + 202. price: £12.95. ISBN: 0-7279-0757-3 Statistics in Medicine. 13: 987-988. DOI: 10.1002/Sim.4780130909  0.203
2009 Hennekens CH, DeMets DL, Bairey Merz CN, Borzak SL, Borer JS. Doing more good than harm: need for a cease fire. The American Journal of Medicine. 122: 315-6. PMID 19332222 DOI: 10.1016/J.Amjmed.2008.10.021  0.201
1993 Klein R, Klein BEK, Linton KLP, Demets DL. The beaver dam eye study: The relation of age-related maculopathy to smoking American Journal of Epidemiology. 137: 190-200. PMID 8452123 DOI: 10.1093/Oxfordjournals.Aje.A116659  0.201
1997 Fleming TR, DeGruttola V, DeMets DL. Surrogate endpoints Aids Clinical Review. 129-143. PMID 9305447  0.196
1992 Love RR, Mazess RB, Barden HS, Epstein S, Newcomb PA, Jordan VC, Carbone PP, Demets DL. Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer Obstetrical and Gynecological Survey. 47: 578-580. DOI: 10.1097/00006254-199208000-00024  0.195
1992 Love R, Mazess R, Barden H, Epstein S, Newcomb P, Jordan V, Carbone P, DeMets D. 92103997 Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer Maturitas. 15: 165. DOI: 10.1016/0378-5122(92)90265-6  0.195
1988 Farrell PM, Gutcher GR, Palta M, DeMets D. Essential fatty acid deficiency in premature infants American Journal of Clinical Nutrition. 48: 220-229. PMID 3407602 DOI: 10.1093/Ajcn/48.2.220  0.189
2013 Packer M, Carson P, Elkayam U, Konstam MA, Moe G, O'Connor C, Rouleau JL, Schocken D, Anderson SA, DeMets DL. Effect of amlodipine on the survival of patients with severe chronic heart failure due to a nonischemic cardiomyopathy: results of the PRAISE-2 study (prospective randomized amlodipine survival evaluation 2). Jacc. Heart Failure. 1: 308-14. PMID 24621933 DOI: 10.1016/J.Jchf.2013.04.004  0.188
2021 Solomon SD, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Lindholm D, Wilderäng U, Öhrn F, Claggett B, Langkilde AM, Petersson M, et al. Dapagliflozin in Heart Failure with Preserved and Mildly Reduced Ejection Fraction: Rationale and Design of the DELIVER Trial. European Journal of Heart Failure. PMID 34051124 DOI: 10.1002/ejhf.2249  0.178
1999 Hjalmarson A, Goldstein S, Fagerberg B, Wedel H, Waagstein F, Kjekshus J, Wikstrand J, Westergren G, Thimell M, El Allaf D, Vítovec J, Aldershvile J, Halinen M, Dietz R, Neuhaus KL, ... ... DeMets DL, et al. Effect of metoprolol CR/XL in chronic heart failure: Metoprolol CR/XL Randomised Intervention Trial in Congestive Heart Failure (MERIT-HF) Lancet. 353: 2001-2007. PMID 10376614 DOI: 10.1016/S0140-6736(99)04440-2  0.173
2011 DeMets DL. Commentary on Anand et al. Clinical Trials (London, England). 8: 722-3; discussion 72. PMID 22167109 DOI: 10.1177/1740774511426581  0.171
1982 May GS, Eberlein KA, Furberg CD, Passamani ER, DeMets DL. Secondary prevention after myocardial infarction: A review of long-term trials Progress in Cardiovascular Diseases. 24: 331-352. PMID 6119737 DOI: 10.1016/0033-0620(82)90010-X  0.164
2023 Rockhold F, Mahaffey K, DeMets D. Training New DMC Members: A Call to Action. Therapeutic Innovation & Regulatory Science. PMID 37749420 DOI: 10.1007/s43441-023-00580-8  0.162
2014 Goff DC, Lloyd-Jones DM, Bennett G, Coady S, D'Agostino RB, Gibbons R, Greenland P, Lackland DT, Levy D, O'Donnell CJ, Robinson JG, Schwartz JS, Shero ST, Smith SC, Sorlie P, ... ... DeMets D, et al. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 129: S49-73. PMID 24222018 DOI: 10.1161/01.Cir.0000437741.48606.98  0.157
2024 Collamore G, DiCorcia MJ, Nagpal Y, Fiedler L, Garone MA, DeMets DL, Maki DG, Hennekens CH. Guidance for healthcare providers on newest guidelines for over-the-counter drug treatment of mild symptoms of COVID-19. (word count=18; limit=20). The American Journal of Medicine. PMID 38490308 DOI: 10.1016/j.amjmed.2024.03.003  0.157
2021 Kim K, Hennekens CH, Martinez L, Gaziano JM, Pfeffer MA, Biglione B, Gitin A, McCabe JB, Cook TD, DeMets DL, Wood SK. Primary care providers should prescribe aspirin to prevent cardiovascular disease based on benefit-risk ratio, not age. Family Medicine and Community Health. 9. PMID 34952844 DOI: 10.1136/fmch-2021-001475  0.154
2014 Jacobs AK, Anderson JL, Halperin JL, Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Fleisher LA, Gidding S, Hochman JS, Kovacs RJ, et al. The evolution and future of ACC/AHA clinical practice guidelines: a 30-year journey: a report of the American College of Cardiology/American Heart Association Task Force on practice guidelines. Circulation. 130: 1208-17. PMID 25092464 DOI: 10.1161/CIR.0000000000000090  0.153
2005 DeMets DL. Evidence-based medicine and clinical practice Controversies in Science and Technology: From Maize to Menopause. 254-269.  0.15
1989 Kaufman SC, Ferris FL, Seigel DG, Davis MD, DeMets DL. Factors associated with visual outcome after photocoagulation for diabetic retinopathy. Diabetic retinopathy study report #13 Investigative Ophthalmology and Visual Science. 30: 23-28. PMID 2912911  0.143
2021 Doran B, Mei C, Varosy PD, Kao DP, Saxon LA, Feldman AM, DeMets D, Bristow MR. The Addition of a Defibrillator to Resynchronization Therapy Decreases Mortality in Patients With Nonischemic Cardiomyopathy. Jacc. Heart Failure. PMID 33992570 DOI: 10.1016/j.jchf.2021.02.013  0.141
1999 Li Z, DeMets DL. On the bias of estimation of a Brownian motion drift following group sequential tests Statistica Sinica. 9: 923-937.  0.14
2014 Stone NJ, Robinson JG, Lichtenstein AH, Bairey Merz CN, Blum CB, Eckel RH, Goldberg AC, Gordon D, Levy D, Lloyd-Jones DM, McBride P, Schwartz JS, Shero ST, Smith SC, Watson K, ... ... DeMets D, et al. 2013 ACC/AHA guideline on the treatment of blood cholesterol to reduce atherosclerotic cardiovascular risk in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 129: S1-45. PMID 24222016 DOI: 10.1161/01.Cir.0000437738.63853.7A  0.139
2023 Wittes J, Fleming T, DeMets D, Ellenberg S, Gerstein H, Pfeffer M, Rockhold F, Yusuf S, Hennekens C. The Data Monitoring Committee: A Collective or a Collection? Therapeutic Innovation & Regulatory Science. PMID 37069466 DOI: 10.1007/s43441-023-00520-6  0.138
2022 Solomon SD, McMurray JJV, Claggett B, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, Desai AS, Jhund PS, Belohlavek J, Chiang CE, et al. Dapagliflozin in Heart Failure with Mildly Reduced or Preserved Ejection Fraction. The New England Journal of Medicine. PMID 36027570 DOI: 10.1056/NEJMoa2206286  0.137
2014 Eckel RH, Jakicic JM, Ard JD, de Jesus JM, Houston Miller N, Hubbard VS, Lee IM, Lichtenstein AH, Loria CM, Millen BE, Nonas CA, Sacks FM, Smith SC, Svetkey LP, Wadden TA, ... ... DeMets D, et al. 2013 AHA/ACC guideline on lifestyle management to reduce cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation. 129: S76-99. PMID 24222015 DOI: 10.1161/01.Cir.0000437740.48606.D1  0.137
2022 Cunningham JW, Vaduganathan M, Claggett BL, Kulac IJ, Desai AS, Jhund PS, de Boer RA, DeMets D, Hernandez AF, Inzucchi SE, Kosiborod MN, Lam CSP, Martinez F, Shah SJ, McGrath MM, et al. Dapagliflozin in Patients Recently Hospitalized With Heart Failure and Mildly Reduced or Preserved Ejection Fraction. Journal of the American College of Cardiology. PMID 36041912 DOI: 10.1016/j.jacc.2022.07.021  0.132
2013 Anderson JL, Halperin JL, Albert NM, Bozkurt B, Brindis RG, Curtis LH, DeMets D, Guyton RA, Hochman JS, Kovacs RJ, Ohman EM, Pressler SJ, Sellke FW, Shen WK, Wann LS, et al. Management of patients with atrial fibrillation (compilation of 2006 ACCF/AHA/ESC and 2011 ACCF/AHA/HRS recommendations): a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Journal of the American College of Cardiology. 61: 1935-44. PMID 23558044 DOI: 10.1016/j.jacc.2013.02.001  0.121
2020 Vardeny O, Kim K, Udell JA, Joseph J, Desai AS, Farkouh ME, Hegde SM, Hernandez AF, McGeer A, Talbot HK, Anand I, Bhatt DL, Cannon CP, DeMets D, Gaziano JM, et al. Effect of High-Dose Trivalent vs Standard-Dose Quadrivalent Influenza Vaccine on Mortality or Cardiopulmonary Hospitalization in Patients With High-risk Cardiovascular Disease: A Randomized Clinical Trial. Jama. PMID 33275134 DOI: 10.1001/jama.2020.23649  0.12
2024 DeMets DL, Halabi S, Thabane L, Wittes J. Society for Clinical Trials Data Monitoring Committee initiative website: Closing the gap. Clinical Trials (London, England). 17407745241238393. PMID 38553441 DOI: 10.1177/17407745241238393  0.12
1990 Demets DL. Data monitoring and sequential analysis—an academic perspective Journal of Acquired Immune Deficiency Syndromes. 3: S124-S133.  0.117
1999 Qu RP, DeMets DL. Bias correction in group sequential analysis with correlated data Statistica Sinica. 9: 939-952.  0.116
1997 Poole-Wilson PA, Bobbio M, Allan JJ, Packer M, O'Connor CM, Demets DL. Amlodipine in chronic heart failure (multiple letters) [2] New England Journal of Medicine. 336: 1023-1024. PMID 9091790 DOI: 10.1056/NEJM199704033361413  0.116
2021 Maki DG, Alter SM, Solano JJ, Adirim TA, DeMets DL, Shih RD, Hennekens CH. COVID-19 control in the United States: the case for masking. The American Journal of Managed Care. 27: e218-e220. PMID 34314121 DOI: 10.37765/ajmc.2021.88670  0.116
2013 O'Gara PT, Kushner FG, Ascheim DD, Casey DE, Chung MK, de Lemos JA, Ettinger SM, Fang JC, Fesmire FM, Franklin BA, Granger CB, Krumholz HM, Linderbaum JA, Morrow DA, Newby LK, ... ... DeMets D, et al. 2013 ACCF/AHA guideline for the management of ST-elevation myocardial infarction: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation. 127: e362-425. PMID 23247304 DOI: 10.1161/CIR.0b013e3182742cf6  0.112
1981 Stein PD, Willis PW, DeMets DL, Bell W, Blackmon JR, Genton E, Messer JV, Sasahara AA, Sautter R, Wenger MK, Walton JA, Hildner FJ, Fowler NO. History and physical examination in acute pulmonary embolism in patients without preexisting cardiac or pulmonary disease The American Journal of Cardiology. 47: 218-223. PMID 7468469 DOI: 10.1016/0002-9149(81)90388-X  0.112
1992 Love RR, Mazess RB, Barden HS, Epstein S, Newcomb PA, Jordan VC, Carbone PP, DeMets DL. Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer. The New England Journal of Medicine. 326: 852-6. PMID 1542321 DOI: 10.1056/NEJM199203263261302  0.106
2002 Love RR, Duc NB, Dinh NV, Shen TZ, Havighurst TC, Allred DC, DeMets DL. Mastectomy and oophorectomy by menstrual cycle phase in women with operable breast cancer. Journal of the National Cancer Institute. 94: 662-9. PMID 11983754  0.1
2014 Jensen MD, Ryan DH, Apovian CM, Ard JD, Comuzzie AG, Donato KA, Hu FB, Hubbard VS, Jakicic JM, Kushner RF, Loria CM, Millen BE, Nonas CA, Pi-Sunyer FX, Stevens J, ... ... DeMets D, et al. 2013 AHA/ACC/TOS guideline for the management of overweight and obesity in adults: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines and The Obesity Society. Circulation. 129: S102-38. PMID 24222017 DOI: 10.1161/01.Cir.0000437739.71477.Ee  0.096
2006 Demets DL, Furberg CD, Friedman LM. Monitoring committees: Why and how Data Monitoring in Clinical Trials: a Case Studies Approach. 3-13. DOI: 10.1007/0-387-30107-0_1  0.095
1977 Bell WR, Simon TL, DeMets DL. The clinical features of submassive and massive pulmonary emboli Obstetrical and Gynecological Survey. 32: 598-600. PMID 904788 DOI: 10.1016/0002-9343(77)90832-4  0.093
2001 Atkinson A.J. J, Colburn WA, DeGruttola VG, DeMets DL, Downing GJ, Hoth DF, Oates JA, Peck CC, Schooley RT, Spilker BA, Woodcock J, Zeger SL. Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework Clinical Pharmacology and Therapeutics. 69: 89-95. PMID 11240971 DOI: 10.1067/mcp.2001.113989  0.087
2021 Robishaw JD, Alter SM, Solano JJ, Shih RD, DeMets DL, Maki DG, Hennekens CH. Genomic surveillance to combat COVID-19: challenges and opportunities. The Lancet. Microbe. PMID 34337584 DOI: 10.1016/S2666-5247(21)00121-X  0.082
1981 Friedman L, DeMets D. The data monitoring committee: how it operates and why. Irb. 3: 6-8. PMID 11661946  0.079
2009 Bailey H, Agger W, Baumgardner D, Burmester JK, Cisler RA, Evertsen J, Glurich I, Hartman D, Yale SH, DeMets D. The Wisconsin Network for Health Research (WiNHR): a statewide, collaborative, multi-disciplinary, research group. Wmj : Official Publication of the State Medical Society of Wisconsin. 108: 453-8. PMID 20131687  0.077
1978 Garrison RJ, Demets DL, Fabsitz RR, Feinleib M. A likelihood ratio test for unequal shared environmental variance in twin studies. Progress in Clinical and Biological Research. 24: 253-9. PMID 212764  0.066
2021 Hennekens CH, Rane M, Solano J, Alter S, Johnson H, Krishnaswamy S, Shih R, Maki D, DeMets DL. Updates on hydroxychloroquine in prevention and treatment of COVID-19. The American Journal of Medicine. PMID 34437834 DOI: 10.1016/j.amjmed.2021.07.035  0.066
2006 Demets DL, Furberg CD, Friedman LM. Introduction to case studies showing benefit from the intervention Data Monitoring in Clinical Trials: a Case Studies Approach. 53-54. DOI: 10.1007/0-387-30107-0_4  0.061
1991 DeMets DL, Meinert CL. Data integrity Controlled Clinical Trials. 12: 727-730. PMID 1665113 DOI: 10.1016/0197-2456(91)90035-K  0.059
1977 Bowden RE, Ware JH, DeMets DL, Keiser HR. Urinary excretion of immunoreactive prostaglandin E: A circadian rhythm and the effect of posture Prostaglandins. 14: 151-161. PMID 897210 DOI: 10.1016/0090-6980(77)90164-2  0.055
1987 Stein PD, Willis PW, DeMets DL, Greenspan RH. Plain chest roentgenogram in patients with acute pulmonary ambolism and no preexisting cardiac or pulmonary disease American Journal of Noninvasive Cardiology. 1: 171-176.  0.053
2006 Demets DL, Furberg CD, Friedman LM. Introduction to case studies showing harmful effects of the intervention Data Monitoring in Clinical Trials: a Case Studies Approach. 179-181. DOI: 10.1007/0-387-30107-0_16  0.053
1984 Davey RJ, Lenes BL, Casper AJ, Demets DL. Adequate survival of red cells from units "undercollected" in citrate-phosphate-dextrose-adenine-one. Transfusion. 24: 319-22. PMID 6464155  0.047
1972 Harris EK, DeMets DL. Effects of intra- and inter-individual variation on distributions of single measurements Clinical Chemistry. 18: 244-249. PMID 5020819  0.046
1972 Harris EK, DeMets DL. Estimation of normal ranges and cumulative proportions by transforming observed distributions to gaussian form Clinical Chemistry. 18: 605-612. PMID 5037904  0.041
2022 Berges M, Foster K, Foster J, Martinez L, Martinez S, Fiedler B, DeMets DL, Maki DG, Hennekens CH. Updates for Health Providers on Monoclonal Antibodies for COVID-19: Less Promising Adjunct and Never an Alternative to Vaccinations. The American Journal of Medicine. PMID 35114173 DOI: 10.1016/j.amjmed.2021.12.019  0.039
1971 Harris EK, DeMets DL. Biological and analytic components of variation in long-term studies of serum constituents in normal subjects. V. Estimated biological variations in ionized calcium Clinical Chemistry. 17: 983-987. PMID 5095152  0.037
2006 Demets DL, Furberg CD, Friedman LM. Introduction to case studies with special issues Data Monitoring in Clinical Trials: a Case Studies Approach. 281-283. DOI: 10.1007/0-387-30107-0_26  0.036
2001 Rahlfs VW, Gong J, Pinheiro JC, DeMets DL. Letters to the editor (multiple letters) Controlled Clinical Trials. 22: 191-194. PMID 11349656 DOI: 10.1016/S0197-2456(00)00129-X  0.033
2000 Varis K, Sipponen P, Laxen F, Samloff IM, Huttunen JK, Taylor PR, Heinonen OP, Albanes D, Sande N, Virtamo J, Harkonen M, Varis KS, Edwards BK, Greenwald P, Butrum R, ... ... DeMets DL, et al. Implications of serum pepsinogen I in early endoscopic diagnosis of gastric cancer and dysplasia Scandinavian Journal of Gastroenterology. 35: 950-956. PMID 11063155 DOI: 10.1080/003655200750023011  0.031
2017 Fleming TR, DeMets DL, Roe MT, Wittes J, Calis KA, Vora AN, Meisel A, Bain RP, Konstam MA, Pencina MJ, Gordon DJ, Mahaffey KW, Hennekens CH, Neaton JD, Pearson GD, et al. Rejoinder. Clinical Trials (London, England). 1740774516688917. PMID 28135837 DOI: 10.1177/1740774516688917  0.01
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