| Year |
Citation |
Score |
| 2023 |
Yang PC, Rose A, DeMarco KR, Dawson JRD, Han Y, Jeng MT, Harvey RD, Santana LF, Ripplinger CM, Vorobyov I, Lewis TJ, Clancy CE. A multiscale predictive digital twin for neurocardiac modulation. The Journal of Physiology. PMID 37528537 DOI: 10.1113/JP284391 |
0.324 |
|
| 2022 |
Maly J, Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of the hERG potassium channel and associated drug interactions. Frontiers in Pharmacology. 13: 966463. PMID 36188564 DOI: 10.3389/fphar.2022.966463 |
0.306 |
|
| 2022 |
Furutani K, Kawano R, Ichiwara M, Adachi R, Clancy CE, Sack JT, Kita S. Pore opening, not voltage sensor movement, underpins the voltage-dependence of facilitation by a hERG blocker. Molecular Pharmacology. PMID 36041862 DOI: 10.1124/molpharm.122.000569 |
0.31 |
|
| 2021 |
Docken SS, Clancy CE, Lewis TJ. Rate-dependent effects of lidocaine on cardiac dynamics: Development and analysis of a low-dimensional drug-channel interaction model. Plos Computational Biology. 17: e1009145. PMID 34185778 DOI: 10.1371/journal.pcbi.1009145 |
0.308 |
|
| 2021 |
Yang PC, Giles WR, Belardinelli L, Clancy CE. Mechanisms of flecainide induced negative inotropy: An in silico study. Journal of Molecular and Cellular Cardiology. PMID 34004185 DOI: 10.1016/j.yjmcc.2021.05.007 |
0.372 |
|
| 2018 |
Perissinotti LL, De Biase PM, Guo J, Yang PC, Lee MC, Clancy CE, Duff HJ, Noskov SY. Determinants of Isoform-Specific Gating Kinetics of hERG1 Channel: Combined Experimental and Simulation Study. Frontiers in Physiology. 9: 207. PMID 29706893 DOI: 10.3389/Fphys.2018.00207 |
0.365 |
|
| 2016 |
Yang PC, Moreno JD, Jeng MT, Wehrens XH, Noskov S, Clancy CE. Reply from Pei-Chi Yang, Jonathan D. Moreno, Mao-Tsuen Jeng, Xander H. T. Wehrens, Sergei Noskov and Colleen E. Clancy. The Journal of Physiology. 594: 6433-6435. PMID 27800622 DOI: 10.1113/Jp273143 |
0.433 |
|
| 2016 |
DeMarco KR, Clancy CE. Cardiac Na Channels: Structure to Function. Current Topics in Membranes. 78: 287-311. PMID 27586288 DOI: 10.1016/bs.ctm.2016.05.001 |
0.305 |
|
| 2016 |
Yang PC, El-Bizri N, Romero L, Giles WR, Rajamani S, Belardinelli L, Clancy CE. A computational model predicts adjunctive pharmacotherapy for cardiac safety via selective inhibition of the late cardiac Na current. Journal of Molecular and Cellular Cardiology. PMID 27545042 DOI: 10.1016/J.Yjmcc.2016.08.011 |
0.322 |
|
| 2016 |
Moreno JD, Lewis TJ, Clancy CE. Parameterization for In-Silico Modeling of Ion Channel Interactions with Drugs. Plos One. 11: e0150761. PMID 26963710 DOI: 10.1371/Journal.Pone.0150761 |
0.559 |
|
| 2016 |
Gray B, Bagnall R, Lam L, Ingles J, Turner C, Haan E, Davis A, Yang P, Clancy C, Sy R, Semsarian C. A Novel Heterozygous Mutation in Cardiac Calsequestrin Causes Catecholaminergic Polymorphic Ventricular Tachycardia Heart, Lung and Circulation. 25: S2-S3. DOI: 10.1016/J.Hlc.2016.06.005 |
0.34 |
|
| 2016 |
Vincent M, Yang P, Clancy CE. A Computational Modeling Investigation into SCN10A Linked Brugada Syndrome Biophysical Journal. 110: 107a-108a. DOI: 10.1016/J.Bpj.2015.11.637 |
0.36 |
|
| 2016 |
Yang P, Boras B, Jeng M, Docken S, Lewis T, McCulloch A, Harvey R, Clancy C. A Computational Investigation Predicts Mechanisms of Subcellular cAMP Compartmentation Biophysical Journal. 110: 590a. DOI: 10.1016/J.Bpj.2015.11.3151 |
0.364 |
|
| 2015 |
Romero L, Trenor B, Yang PC, Saiz J, Clancy CE. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. Journal of Molecular and Cellular Cardiology. 87: 271-82. PMID 26859003 |
0.337 |
|
| 2015 |
Yang PC, Moreno JD, Miyake CY, Vaughn-Behrens SB, Jeng MT, Grandi E, Wehrens XH, Noskov S, Clancy CE. In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia. The Journal of Physiology. PMID 26515697 DOI: 10.1113/Jp271282 |
0.599 |
|
| 2015 |
Perissinotti LL, Guo J, De Biase PM, Clancy CE, Duff HJ, Noskov SY. Kinetic model for NS1643 drug activation of WT and L529I variants of Kv11.1 (hERG1) potassium channel. Biophysical Journal. 108: 1414-24. PMID 25809254 DOI: 10.1016/J.Bpj.2014.12.056 |
0.328 |
|
| 2015 |
Clancy CE, Chen-Izu Y, Bers DM, Belardinelli L, Boyden PA, Csernoch L, Despa S, Fermini B, Hool LC, Izu L, Kass RS, Lederer WJ, Louch WE, Maack C, Matiazzi A, et al. Deranged sodium to sudden death. The Journal of Physiology. 593: 1331-45. PMID 25772289 DOI: 10.1113/Jphysiol.2014.281204 |
0.318 |
|
| 2015 |
Yang PC, Song Y, Giles WR, Horvath B, Chen-Izu Y, Belardinelli L, Rajamani S, Clancy CE. A computational modelling approach combined with cellular electrophysiology data provides insights into the therapeutic benefit of targeting the late Na+ current. The Journal of Physiology. 593: 1429-42. PMID 25545172 DOI: 10.1113/jphysiol.2014.279554 |
0.346 |
|
| 2014 |
Romero L, Trenor B, Yang PC, Saiz J, Clancy CE. In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome. Journal of Molecular and Cellular Cardiology. 72: 126-37. PMID 24631769 DOI: 10.1016/j.yjmcc.2014.02.018 |
0.339 |
|
| 2014 |
Agarwal SR, Yang P, Clancy C, Harvey R. Compartmentation of Camp Signaling in Complex and Simple Cells Biophysical Journal. 106: 776a-777a. DOI: 10.1016/J.Bpj.2013.11.4258 |
0.317 |
|
| 2013 |
Moreno JD, Yang PC, Bankston JR, Grandi E, Bers DM, Kass RS, Clancy CE. Ranolazine for congenital and acquired late INa-linked arrhythmias: in silico pharmacological screening. Circulation Research. 113: e50-61. PMID 23897695 DOI: 10.1161/Circresaha.113.301971 |
0.75 |
|
| 2013 |
Nawathe PA, Kryukova Y, Oren RV, Milanesi R, Clancy CE, Lu JT, Moss AJ, Difrancesco D, Robinson RB. An LQTS6 MiRP1 mutation suppresses pacemaker current and is associated with sinus bradycardia. Journal of Cardiovascular Electrophysiology. 24: 1021-7. PMID 23631727 DOI: 10.1111/Jce.12163 |
0.733 |
|
| 2013 |
Lewin N, Aksay E, Clancy CE. Correction: Computational Modeling Reveals Dendritic Origins of GABAA-Mediated Excitation in CA1 Pyramidal Neurons Plos One. 8. DOI: 10.1371/Annotation/D6Af29Ee-25C0-4F8E-910E-Afe53Ef8F963 |
0.718 |
|
| 2012 |
Lewin N, Aksay E, Clancy CE. Computational modeling reveals dendritic origins of GABA(A)-mediated excitation in CA1 pyramidal neurons. Plos One. 7: e47250. PMID 23071770 DOI: 10.1371/Journal.Pone.0047250 |
0.729 |
|
| 2012 |
Roberts BN, Yang PC, Behrens SB, Moreno JD, Clancy CE. Computational approaches to understand cardiac electrophysiology and arrhythmias. American Journal of Physiology. Heart and Circulatory Physiology. 303: H766-83. PMID 22886409 DOI: 10.1152/Ajpheart.01081.2011 |
0.577 |
|
| 2012 |
Moreno JD, Clancy CE. Pathophysiology of the cardiac late Na current and its potential as a drug target. Journal of Molecular and Cellular Cardiology. 52: 608-19. PMID 22198344 DOI: 10.1016/J.Yjmcc.2011.12.003 |
0.622 |
|
| 2011 |
Moreno JD, Zhu ZI, Yang PC, Bankston JR, Jeng MT, Kang C, Wang L, Bayer JD, Christini DJ, Trayanova NA, Ripplinger CM, Kass RS, Clancy CE. A computational model to predict the effects of class I anti-arrhythmic drugs on ventricular rhythms. Science Translational Medicine. 3: 98ra83. PMID 21885405 DOI: 10.1126/Scitranslmed.3002588 |
0.754 |
|
| 2010 |
Oren RV, Clancy CE. Determinants of heterogeneity, excitation and conduction in the sinoatrial node: a model study. Plos Computational Biology. 6: e1001041. PMID 21203483 DOI: 10.1371/Journal.Pcbi.1001041 |
0.729 |
|
| 2010 |
Yang PC, Kurokawa J, Furukawa T, Clancy CE. Acute effects of sex steroid hormones on susceptibility to cardiac arrhythmias: a simulation study. Plos Computational Biology. 6: e1000658. PMID 20126530 DOI: 10.1371/Journal.Pcbi.1000658 |
0.309 |
|
| 2010 |
Protas L, Oren RV, Clancy CE, Robinson RB. Age-dependent changes in Na current magnitude and TTX-sensitivity in the canine sinoatrial node. Journal of Molecular and Cellular Cardiology. 48: 172-80. PMID 19665465 DOI: 10.1016/J.Yjmcc.2009.07.028 |
0.728 |
|
| 2010 |
Moreno JD, Bankston JR, Kass RS, Clancy C. Cardiac Dynamics In-Silico: Pharmacological Targeting of Long QT3 Syndrome Biophysical Journal. 98: 8a. DOI: 10.1016/J.Bpj.2009.12.050 |
0.756 |
|
| 2009 |
Moreno JD, Clancy CE. Using computational modeling to predict arrhythmogenesis and antiarrhythmic therapy. Drug Discovery Today. Disease Models. 6: 71-84. PMID 20652086 DOI: 10.1016/J.Ddmod.2010.03.001 |
0.603 |
|
| 2009 |
Zhao X, Bucchi A, Oren RV, Kryukova Y, Dun W, Clancy CE, Robinson RB. In vitro characterization of HCN channel kinetics and frequency dependence in myocytes predicts biological pacemaker functionality. The Journal of Physiology. 587: 1513-25. PMID 19171659 DOI: 10.1113/Jphysiol.2008.163444 |
0.737 |
|
| 2008 |
Furukawa T, Kurokawa J, Clancy CE. A Combined Approach Using Patch-Clamp Study and Computer Simulation Study for Understanding Long QT Syndrome and TdP in Women. Current Cardiology Reviews. 4: 244-50. PMID 20066131 DOI: 10.2174/157340308786349507 |
0.336 |
|
| 2007 |
Nakamura H, Kurokawa J, Bai CX, Asada K, Xu J, Oren RV, Zhu ZI, Clancy CE, Isobe M, Furukawa T. Progesterone regulates cardiac repolarization through a nongenomic pathway: an in vitro patch-clamp and computational modeling study. Circulation. 116: 2913-22. PMID 18056530 DOI: 10.1161/Circulationaha.107.702407 |
0.722 |
|
| 2007 |
Zhu ZI, Clancy CE. Genetic mutations and arrhythmia: simulation from DNA to electrocardiogram. Journal of Electrocardiology. 40: S47-50. PMID 17993328 DOI: 10.1016/j.jelectrocard.2007.05.033 |
0.338 |
|
| 2007 |
Zhu ZI, Clancy CE. L-type Ca2+ channel mutations and T-wave alternans: a model study. American Journal of Physiology. Heart and Circulatory Physiology. 293: H3480-9. PMID 17933974 DOI: 10.1152/ajpheart.00476.2007 |
0.337 |
|
| 2007 |
Clancy CE, Wehrens XH. Mutation-specific effects of lidocaine in Brugada syndrome. International Journal of Cardiology. 121: 249-52. PMID 17761312 DOI: 10.1016/j.ijcard.2007.05.060 |
0.32 |
|
| 2007 |
Clancy CE, Zhu ZI, Rudy Y. Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation. American Journal of Physiology. Heart and Circulatory Physiology. 292: H66-75. PMID 16997895 DOI: 10.1152/Ajpheart.00312.2006 |
0.316 |
|
| 2006 |
Choe CU, Schulze-Bahr E, Neu A, Xu J, Zhu ZI, Sauter K, Bähring R, Priori S, Guicheney P, Mönnig G, Neapolitano C, Heidemann J, Clancy CE, Pongs O, Isbrandt D. C-terminal HERG (LQT2) mutations disrupt IKr channel regulation through 14-3-3epsilon. Human Molecular Genetics. 15: 2888-902. PMID 16923798 DOI: 10.1093/Hmg/Ddl230 |
0.305 |
|
| 2006 |
Glaaser IW, Clancy CE. Cardiac Na+ channels as therapeutic targets for antiarrhythmic agents. Handbook of Experimental Pharmacology. 99-121. PMID 16610342 DOI: 10.1007/3-540-29715-4_4 |
0.314 |
|
| 2005 |
Terrenoire C, Clancy CE, Cormier JW, Sampson KJ, Kass RS. Autonomic control of cardiac action potentials: role of potassium channel kinetics in response to sympathetic stimulation. Circulation Research. 96: e25-34. PMID 15731462 DOI: 10.1161/01.Res.0000160555.58046.9A |
0.307 |
|
| 2005 |
Clancy CE, Kass RS. Inherited and acquired vulnerability to ventricular arrhythmias: cardiac Na+ and K+ channels. Physiological Reviews. 85: 33-47. PMID 15618477 DOI: 10.1152/physrev.00005.2004 |
0.316 |
|
| 2003 |
Clancy CE, Tateyama M, Liu H, Wehrens XH, Kass RS. Non-equilibrium gating in cardiac Na+ channels: an original mechanism of arrhythmia. Circulation. 107: 2233-7. PMID 12695286 DOI: 10.1161/01.CIR.0000069273.51375.BD |
0.338 |
|
| 2002 |
Clancy CE, Tateyama M, Kass RS. Insights into the molecular mechanisms of bradycardia-triggered arrhythmias in long QT-3 syndrome. The Journal of Clinical Investigation. 110: 1251-62. PMID 12417563 DOI: 10.1172/JCI15928 |
0.32 |
|
| 2002 |
Clancy CE, Kass RS. Defective cardiac ion channels: from mutations to clinical syndromes. The Journal of Clinical Investigation. 110: 1075-7. PMID 12393842 DOI: 10.1172/JCI16945 |
0.361 |
|
| 2002 |
Rivolta I, Clancy CE, Tateyama M, Liu H, Priori SG, Kass RS. A novel SCN5A mutation associated with long QT-3: altered inactivation kinetics and channel dysfunction. Physiological Genomics. 10: 191-7. PMID 12209021 DOI: 10.1152/physiolgenomics.00039.2002 |
0.334 |
|
| 2001 |
Clancy CE, Rudy Y. Cellular consequences of HERG mutations in the long QT syndrome: Precursors to sudden cardiac death Cardiovascular Research. 50: 301-313. PMID 11334834 DOI: 10.1016/S0008-6363(00)00293-5 |
0.352 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2016 |
Chiamvimonvat N, Chen-Izu Y, Clancy CE, Deschenes I, Dobrev D, Heijman J, Izu L, Qu Z, Ripplinger CM, Vandenberg JI, Weiss JN, Koren G, Banyasz T, Grandi E, Sanguinetti MC, et al. Potassium currents in the heart: Functional roles in repolarization, arrhythmia and therapeutics. The Journal of Physiology. PMID 27808412 DOI: 10.1113/Jp272883 |
0.3 |
|
| 2002 |
Clancy CE, Rudy Y. Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism. Circulation. 105: 1208-13. PMID 11889015 DOI: 10.1161/Hc1002.105183 |
0.299 |
|
| 2018 |
Docken SS, Lewis TJ, Clancy CE. Mechanisms Underlying Rate-Dependent Effects of State-Specific Binding of Sodium Channel Blockers in Cardiac Tissue: Insights from Idealized Models Biophysical Journal. 114: 489a. DOI: 10.1016/J.Bpj.2017.11.2682 |
0.294 |
|
| 2021 |
DeMarco KR, Yang PC, Singh V, Furutani K, Dawson JRD, Jeng MT, Fettinger J, Bekker S, Ngo VA, Noskov SY, Yarov-Yarovoy V, Sack JT, Wulff H, Clancy CE, Vorobyov I. Molecular determinants of pro-arrhythmia proclivity of d- and l-sotalol via a multi-scale modeling pipeline. Journal of Molecular and Cellular Cardiology. PMID 34062207 DOI: 10.1016/j.yjmcc.2021.05.015 |
0.293 |
|
| 2008 |
Rudy Y, Ackerman MJ, Bers DM, Clancy CE, Houser SR, London B, McCulloch AD, Przywara DA, Rasmusson RL, Solaro RJ, Trayanova NA, Van Wagoner DR, Varró A, Weiss JN, Lathrop DA. Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary. Circulation. 118: 1202-11. PMID 18779456 DOI: 10.1161/Circulationaha.108.772715 |
0.292 |
|
| 2014 |
Yarov-Yarovoy V, Allen TW, Clancy CE. Computational Models for Predictive Cardiac Ion Channel Pharmacology. Drug Discovery Today. Disease Models. 14: 3-10. PMID 26635886 DOI: 10.1016/J.Ddmod.2014.04.001 |
0.291 |
|
| 2014 |
Yang P, Harvey RD, Clancy CE. Computational Investigation into Female Susceptibility to Arousal Induced Arrhythmias in Long-Qt Syndrome Type 2 Biophysical Journal. 106: 721a. DOI: 10.1016/J.Bpj.2013.11.3984 |
0.29 |
|
| 2019 |
Kernik DC, Morotti S, Wu H, Garg P, Duff HJ, Kurokawa J, Jalife J, Wu JC, Grandi E, Clancy CE. A computational model of induced pluripotent stem-cell derived cardiomyocytes incorporating experimental variability from multiple data sources. The Journal of Physiology. PMID 31278749 DOI: 10.1113/Jp277724 |
0.289 |
|
| 2018 |
Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Yarov-Yarovoy V. Structural Modeling of Local Anesthetic and Antiarrhythmic Drug Binding to the Human Cardiac Voltage Gated Sodium Channel Biophysical Journal. 114: 39a. DOI: 10.1016/J.Bpj.2017.11.263 |
0.289 |
|
| 2016 |
Kurokawa J, Kodama M, Clancy CE, Furukawa T. Sex hormonal regulation of cardiac ion channels in drug-induced QT syndromes. Pharmacology & Therapeutics. PMID 27595633 DOI: 10.1016/J.Pharmthera.2016.09.004 |
0.288 |
|
| 2008 |
Xu J, Clancy CE. Ionic mechanisms of endogenous bursting in CA3 hippocampal pyramidal neurons: a model study. Plos One. 3: e2056. PMID 18446231 DOI: 10.1371/journal.pone.0002056 |
0.288 |
|
| 2003 |
Liu H, Clancy CE, Cormier JW, Kass RS. Mutations in cardiac sodium channels: Clinical implications American Journal of Pharmacogenomics. 3: 173-179. PMID 12814325 DOI: 10.2165/00129785-200303030-00003 |
0.282 |
|
| 2002 |
Liu H, Tateyama M, Clancy CE, Abriel H, Kass RS. Channel openings are necessary but not sufficient for use-dependent block of cardiac Na(+) channels by flecainide: evidence from the analysis of disease-linked mutations. The Journal of General Physiology. 120: 39-51. PMID 12084774 DOI: 10.1085/Jgp.20028558 |
0.281 |
|
| 1999 |
Clancy CE, Rudy Y. Linking a genetic defect to its cellular phenotype in a cardiac arrhythmia Nature. 400: 566-569. PMID 10448858 DOI: 10.1038/23034 |
0.28 |
|
| 2004 |
Clancy CE, Kass RS. Theoretical investigation of the neuronal Na+ channel SCN1A: abnormal gating and epilepsy. Biophysical Journal. 86: 2606-14. PMID 15041696 DOI: 10.1016/S0006-3495(04)74315-5 |
0.279 |
|
| 2022 |
Guarina L, Moghbel AN, Pourhosseinzadeh MS, Cudmore RH, Sato D, Clancy CE, Santana LF. Biological noise is a key determinant of the reproducibility and adaptability of cardiac pacemaking and EC coupling. The Journal of General Physiology. 154. PMID 35482009 DOI: 10.1085/jgp.202012613 |
0.276 |
|
| 2016 |
Perez LR, Noskov SY, Clancy CE. Computational Modeling of Cardiac K+ Channels and Channelopathies Ion Channels in Health and Disease. 293-330. DOI: 10.1016/B978-0-12-802002-9.00012-1 |
0.276 |
|
| 2023 |
Emigh Cortez AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Wulff H, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural modeling of hERG channel-drug interactions using Rosetta. Frontiers in Pharmacology. 14: 1244166. PMID 38035013 DOI: 10.3389/fphar.2023.1244166 |
0.275 |
|
| 2020 |
Yang PC, DeMarco KR, Aghasafari P, Jeng MT, Dawson JR, Bekker S, Noskov S, Yarov-Yarovoy V, Vorobyov I, Clancy CE. A Computational Pipeline to Predict Cardiotoxicity:From the Atom to the Rhythm. Circulation Research. PMID 32091972 DOI: 10.1161/Circresaha.119.316404 |
0.273 |
|
| 2017 |
Sato D, Clancy CE, Bers DM. Dynamics of sodium current mediated early afterdepolarizations. Heliyon. 3: e00388. PMID 28924617 DOI: 10.1016/J.Heliyon.2017.E00388 |
0.272 |
|
| 2019 |
Clancy C, Volgushev M. Decision letter: Clusters of cooperative ion channels enable a membrane-potential-based mechanism for short-term memory Elife. DOI: 10.7554/Elife.49974.Sa1 |
0.27 |
|
| 2016 |
Yang P, Wang Y, Perissinotti LL, Kurokawa J, DeMarco KR, Jeng M, Harvey RD, Clancy CE. An in Silico Study of Female Susceptibility to Arousal-Induced Arrhythmias Biophysical Journal. 110: 585a. DOI: 10.1016/J.Bpj.2015.11.3126 |
0.266 |
|
| 2020 |
Aghasafari P, Yang P, Clancy C. Application of Machine Learning Techniques for Testing Sensitivity of Cardiac Dynamics to Arrhythmia Vulnerability Parameters The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07253 |
0.265 |
|
| 2023 |
Docken SS, Clancy CE, Lewis TJ. Rate-dependent effects of state-specific sodium channel blockers in cardiac tissue: Insights from idealized models. Journal of Theoretical Biology. 573: 111595. PMID 37562674 DOI: 10.1016/j.jtbi.2023.111595 |
0.264 |
|
| 2002 |
Splawski I, Timothy KW, Tateyama M, Clancy CE, Malhotra A, Beggs AH, Cappuccio FP, Sagnella GA, Kass RS, Keating MT. Variant of SCN5A sodium channel implicated in risk of cardiac arrhythmia. Science (New York, N.Y.). 297: 1333-6. PMID 12193783 DOI: 10.1126/Science.1073569 |
0.262 |
|
| 2015 |
Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, ... ... Clancy CE, et al. Na+ channel function, regulation, structure, trafficking and sequestration. The Journal of Physiology. 593: 1347-60. PMID 25772290 DOI: 10.1113/Jphysiol.2014.281428 |
0.261 |
|
| 2024 |
Hernandez-Hernandez G, O'Dwyer SC, Yang PC, Matsumoto C, Tieu M, Fong Z, Lewis TJ, Santana LF, Clancy CE. A computational model predicts sex-specific responses to calcium channel blockers in mammalian mesenteric vascular smooth muscle. Elife. 12. PMID 38335126 DOI: 10.7554/eLife.90604 |
0.26 |
|
| 2003 |
Clancy CE, Kurokawa J, Tateyama M, Wehrens XH, Kass RS. K+ channel structure-activity relationships and mechanisms of drug-induced QT prolongation. Annual Review of Pharmacology and Toxicology. 43: 441-61. PMID 12540747 DOI: 10.1146/Annurev.Pharmtox.43.100901.140245 |
0.26 |
|
| 2023 |
Hernandez-Hernandez G, O'Dwyer SC, Matsumoto C, Tieu M, Fong Z, Yang PC, Lewis TJ, Fernando Santana L, Clancy CE. A computational model predicts sex-specific responses to calcium channel blockers in mesenteric vascular smooth muscle. Biorxiv : the Preprint Server For Biology. PMID 37425682 DOI: 10.1101/2023.06.24.546394 |
0.259 |
|
| 2005 |
Royer A, Demolombe S, El Harchi A, Le Quang K, Piron J, Toumaniantz G, Mazurais D, Bellocq C, Lande G, Terrenoire C, Motoike HK, Chevallier JC, Loussouarn G, Clancy CE, Escande D, et al. Expression of human ERG K+ channels in the mouse heart exerts anti-arrhythmic activity. Cardiovascular Research. 65: 128-37. PMID 15621040 DOI: 10.1016/j.cardiores.2004.09.030 |
0.257 |
|
| 2010 |
Yang PC, Clancy CE. Effects of sex hormones on cardiac repolarization. Journal of Cardiovascular Pharmacology. 56: 123-9. PMID 20164789 DOI: 10.1097/FJC.0b013e3181d6f7dd |
0.255 |
|
| 2016 |
DeMarco K, Boiteux C, Allen TW, Yarov-Yarovoy V, Clancy CE. Molecular Scale Prediction of Lidocaine Interaction with the Pore Domain of Human Nav1.5 Biophysical Journal. 110: 107a. DOI: 10.1016/J.Bpj.2015.11.636 |
0.253 |
|
| 2023 |
Ngo K, Mateos DL, Rouen K, Han Y, Wulff H, Clancy CE, Yarov-Yarovoy V, Vorobyov I. Elucidating Molecular Mechanisms of Protoxin-2 State-specific Binding to the Human Na 1.7 Channel. Biorxiv : the Preprint Server For Biology. PMID 36909474 DOI: 10.1101/2023.02.27.530360 |
0.252 |
|
| 2015 |
Shattock MJ, Ottolia M, Bers DM, Blaustein MP, Boguslavskyi A, Bossuyt J, Bridge JH, Chen-Izu Y, Clancy CE, Edwards A, Goldhaber J, Kaplan J, Lingrel JB, Pavlovic D, Philipson K, et al. Na+/Ca2+ exchange and Na+/K+-ATPase in the heart. The Journal of Physiology. 593: 1361-82. PMID 25772291 DOI: 10.1113/Jphysiol.2014.282319 |
0.25 |
|
| 2018 |
Rodriguez B, Clancy C. Decision letter: The Ca2+ transient as a feedback sensor controlling cardiomyocyte ionic conductances in mouse populations Elife. DOI: 10.7554/Elife.36717.025 |
0.25 |
|
| 2023 |
Yang PC, Jeng MT, Yarov-Yarovoy V, Santana LF, Vorobyov I, Clancy CE. Toward Digital Twin Technology for Precision Pharmacology. Jacc. Clinical Electrophysiology. PMID 38069976 DOI: 10.1016/j.jacep.2023.10.024 |
0.25 |
|
| 2009 |
Ahrens-Nicklas RC, Clancy CE, Christini DJ. Re-evaluating the efficacy of beta-adrenergic agonists and antagonists in long QT-3 syndrome through computational modelling. Cardiovascular Research. 82: 439-47. PMID 19264765 DOI: 10.1093/cvr/cvp083 |
0.249 |
|
| 2019 |
Dawson JR, DeMarco KR, Bekker B, Noskov SY, Clancy CE, Vorobyov IV. In Silico Determination of Open Conducting and Inactivated Atomistic KV11.1 Channel Models Biophysical Journal. 116: 103a. DOI: 10.1016/J.Bpj.2018.11.591 |
0.246 |
|
| 2012 |
Yang PC, Clancy CE. In silico Prediction of Sex-Based Differences in Human Susceptibility to Cardiac Ventricular Tachyarrhythmias. Frontiers in Physiology. 3: 360. PMID 23049511 DOI: 10.3389/fphys.2012.00360 |
0.244 |
|
| 2020 |
Kernik DC, Yang PC, Kurokawa J, Wu JC, Clancy CE. A computational model of induced pluripotent stem-cell derived cardiomyocytes for high throughput risk stratification of KCNQ1 genetic variants. Plos Computational Biology. 16: e1008109. PMID 32797034 DOI: 10.1371/Journal.Pcbi.1008109 |
0.244 |
|
| 2023 |
Ngo K, Lopez Mateos D, Han Y, Rouen KC, Ahn SH, Wulff H, Clancy CE, Yarov-Yarovoy V, Vorobyov I. Elucidating molecular mechanisms of protoxin-II state-specific binding to the human NaV1.7 channel. The Journal of General Physiology. 156. PMID 38127314 DOI: 10.1085/jgp.202313368 |
0.24 |
|
| 2020 |
Miranda WE, DeMarco KR, Guo J, Duff HJ, Vorobyov I, Clancy CE, Noskov SY. Selectivity filter modalities and rapid inactivation of the hERG1 channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 31980532 DOI: 10.1073/Pnas.1909196117 |
0.24 |
|
| 2016 |
Yang PC, Boras BW, Jeng MT, Docken SS, Lewis TJ, McCulloch AD, Harvey RD, Clancy CE. A Computational Modeling and Simulation Approach to Investigate Mechanisms of Subcellular cAMP Compartmentation. Plos Computational Biology. 12: e1005005. PMID 27409243 DOI: 10.1371/Journal.Pcbi.1005005 |
0.24 |
|
| 2021 |
Harvey RD, Clancy CE. Mechanisms of cAMP compartmentation in cardiac myocytes: Experimental and computational approaches to understanding. The Journal of Physiology. PMID 34510451 DOI: 10.1113/JP280801 |
0.24 |
|
| 2019 |
Nguyen PT, DeMarco KR, Vorobyov I, Clancy CE, Yarov-Yarovoy V. Structural basis for antiarrhythmic drug interactions with the human cardiac sodium channel. Proceedings of the National Academy of Sciences of the United States of America. PMID 30728299 DOI: 10.1073/Pnas.1817446116 |
0.239 |
|
| 2012 |
Kurokawa J, Kodama M, Furukawa T, Clancy CE. Sex and gender aspects in antiarrhythmic therapy. Handbook of Experimental Pharmacology. 237-63. PMID 23027454 DOI: 10.1007/978-3-642-30726-3_12 |
0.239 |
|
| 2017 |
Yang PC, Perissinotti LL, López-Redondo F, Wang Y, DeMarco KR, Jeng MT, Vorobyov I, Harvey RD, Kurokawa J, Noskov SY, Clancy CE. A multiscale computational modelling approach predicts mechanisms of female sex risk in the setting of arousal-induced arrhythmias. The Journal of Physiology. PMID 28516454 DOI: 10.1113/Jp273142 |
0.237 |
|
| 2011 |
Yang PC, Clancy CE. Gender-based differences in cardiac diseases. Journal of Biomedical Research. 25: 81-9. PMID 23554675 DOI: 10.1016/S1674-8301(11)60010-9 |
0.236 |
|
| 2007 |
Lehnart SE, Ackerman MJ, Benson DW, Brugada R, Clancy CE, Donahue JK, George AL, Grant AO, Groft SC, January CT, Lathrop DA, Lederer WJ, Makielski JC, Mohler PJ, Moss A, et al. Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function. Circulation. 116: 2325-45. PMID 17998470 DOI: 10.1161/Circulationaha.107.711689 |
0.236 |
|
| 2003 |
Tateyama M, Rivolta I, Clancy CE, Kass RS. Modulation of cardiac sodium channel gating by protein kinase A can be altered by disease-linked mutation. The Journal of Biological Chemistry. 278: 46718-26. PMID 14500710 DOI: 10.1074/jbc.M308977200 |
0.234 |
|
| 2017 |
DeMarco KR, Nguyen PT, Allen TW, Yarov-Yarovoy V, Clancy CE, Vorobyov I. State-Dependent Structural Modeling and Atomistic Simulations of the hERG Potassium Channel Biophysical Journal. 112: 542a. DOI: 10.1016/J.Bpj.2016.11.2929 |
0.232 |
|
| 2019 |
Yang PC, Purawat S, Ieong PU, Jeng MT, DeMarco KR, Vorobyov I, McCulloch AD, Altinas I, Amaro RE, Clancy CE. A demonstration of modularity, reuse, reproducibility, portability and scalability for modeling and simulation of cardiac electrophysiology using Kepler Workflows. Plos Computational Biology. 15: e1006856. PMID 30849072 DOI: 10.1371/Journal.Pcbi.1006856 |
0.231 |
|
| 2015 |
Sihn CR, Kim HJ, Woltz RL, Yarov-Yarovoy V, Yang PC, Xu J, Clancy CE, Zhang XD, Chiamvimonvat N, Yamoah EN. Mechanisms of Calmodulin Regulation of Different Isoforms of Kv7.4 K+ Channels. The Journal of Biological Chemistry. PMID 26515070 DOI: 10.1074/Jbc.M115.668236 |
0.229 |
|
| 2013 |
Sato D, Clancy CE. Cardiac electrophysiological dynamics from the cellular level to the organ level. Biomedical Engineering and Computational Biology. 5: 69-75. PMID 25288904 DOI: 10.4137/BECB.S10960 |
0.227 |
|
| 2024 |
Ngo K, Yarov-Yarovoy V, Clancy CE, Vorobyov I. Harnessing AlphaFold to reveal state secrets: Prediction of hERG closed and inactivated states. Biorxiv : the Preprint Server For Biology. PMID 38352360 DOI: 10.1101/2024.01.27.577468 |
0.227 |
|
| 2009 |
Clancy CE. Predictive Computational Models Of Complex Biological Systems: Antiarrhythmics And Cardiac Tissue Dynamics Biophysical Journal. 96: 214a-215a. DOI: 10.1016/j.bpj.2008.12.1887 |
0.223 |
|
| 2009 |
Yang P, Clancy CE. Gender Difference in Cardiac Repolarization: A Computational Study Biophysical Journal. 96: 666a-667a. DOI: 10.1016/j.bpj.2008.12.3522 |
0.222 |
|
| 2003 |
Glaaser IW, Kass RS, Clancy CE. Mechanisms of genetic arrhythmias: from DNA to ECG. Progress in Cardiovascular Diseases. 46: 259-70. PMID 14685943 DOI: 10.1016/S0033-0620(03)00073-2 |
0.221 |
|
| 2016 |
Gray B, Bagnall RD, Lam L, Ingles J, Turner C, Haan E, Davis A, Yang PC, Clancy CE, Sy RW, Semsarian C. A novel heterozygous mutation in cardiac calsequestrin causes autosomal dominant catecholaminergic polymorphic ventricular tachycardia. Heart Rhythm : the Official Journal of the Heart Rhythm Society. PMID 27157848 DOI: 10.1016/j.hrthm.2016.05.004 |
0.221 |
|
| 2019 |
Maly J, Emigh AM, DeMarco KR, Sack JT, Vorobyov I, Clancy CE, Yarov-Yarovoy V. Structural Modeling of the HERG Channel in an Inactivated State and its Drug Interactions Biophysical Journal. 116: 104a. DOI: 10.1016/j.bpj.2018.11.598 |
0.22 |
|
| 2020 |
Maly J, Emigh AM, DeMarco K, Sack JT, Vorobyov IV, Clancy CE, Yarov-Yarovoy V. Structural Modeling of the hERG Channel in an Inactivated State and Associated Drug Interactions Biophysical Journal. 118: 212a. DOI: 10.1016/J.Bpj.2019.11.1265 |
0.219 |
|
| 2018 |
Emigh AM, DeMarco KR, Furutani K, Bekker S, Sack JT, Clancy CE, Vorobyov I, Yarov-Yarovoy V. Structural Modeling of hERG Channel Interactions with Drugs using Rosetta Biophysical Journal. 114: 486a. DOI: 10.1016/J.Bpj.2017.11.2667 |
0.216 |
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| 2019 |
Emigh AM, DeMarco KR, Furutani K, Sack JT, Clancy CE, Vorobyov IV, Yarov-Yarovoy V. Structural Modeling of Drug Interactions with hERG Channel in Open and Closed States Biophysical Journal. 116: 249a-250a. DOI: 10.1016/J.Bpj.2018.11.1363 |
0.214 |
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| 2021 |
Fogli Iseppe A, Ni H, Zhu S, Zhang X, Coppini R, Yang PC, Srivatsa U, Clancy CE, Edwards AG, Morotti S, Grandi E. Sex-specific classification of drug-induced Torsade de Pointes susceptibility using cardiac simulations and machine learning. Clinical Pharmacology and Therapeutics. PMID 33772748 DOI: 10.1002/cpt.2240 |
0.214 |
|
| 2018 |
DeMarco KR, Bekker S, Clancy CE, Noskov SY, Vorobyov I. Atomistic Simulation of Lipid Membrane Permeation for Cardiac Ion Channel Blockers Biophysical Journal. 114: 310a. DOI: 10.1016/J.Bpj.2017.11.1755 |
0.212 |
|
| 2019 |
Li Z, Mirams GR, Yoshinaga T, Ridder BJ, Han X, Chen JE, Stockbridge NL, Wisialowski TA, Damiano B, Severi S, Morissette P, Kowey PR, Holbrook M, Smith G, Rasmusson RL, ... ... Clancy CE, et al. General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy. Clinical Pharmacology and Therapeutics. PMID 31709525 DOI: 10.1002/Cpt.1647 |
0.211 |
|
| 2018 |
Vorobyov I, Brown BM, DeMarco KR, Noskov SY, Yarov-Yarovoy V, Wulff H, Clancy CE. Molecular Determinants of Steroid Hormone and Drug Induced Arrhythmogenesis via hERG Channel Block Biophysical Journal. 114: 486a. DOI: 10.1016/J.Bpj.2017.11.2670 |
0.207 |
|
| 2021 |
Meyer EE, Clancy CE, Lewis TJ. Dynamics of adrenergic signaling in cardiac myocytes and implications for pharmacological treatment. Journal of Theoretical Biology. 519: 110619. PMID 33740423 DOI: 10.1016/j.jtbi.2021.110619 |
0.206 |
|
| 2016 |
Clancy CE, An G, Cannon WR, Liu Y, May EE, Ortoleva P, Popel AS, Sluka JP, Su J, Vicini P, Zhou X, Eckmann DM. Multiscale Modeling in the Clinic: Drug Design and Development. Annals of Biomedical Engineering. PMID 26885640 DOI: 10.1007/S10439-016-1563-0 |
0.206 |
|
| 2015 |
Romero L, Trenor B, Yang P, Saiz J, Clancy CE. Corrigendum to “In silico screening of the impact of hERG channel kinetic abnormalities on channel block and susceptibility to acquired long QT syndrome” [J. Mol. Cell. Cardiol. 2014 126–137] Journal of Molecular and Cellular Cardiology. 87: 270. DOI: 10.1016/J.YJMCC.2015.07.022 |
0.205 |
|
| 1995 |
CLANCY C, FRAME M. FRACTAL GEOMETRY OF RESTRICTED SETS OF CIRCLE INVERSIONS Fractals. 3: 689-699. DOI: 10.1142/S0218348X95000618 |
0.201 |
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| 2006 |
Zhu Z, Clancy C. AB31-1 Heart Rhythm. 3: S64. DOI: 10.1016/J.Hrthm.2006.02.202 |
0.198 |
|
| 2016 |
Zhang Y, Barocas VH, Berceli SA, Clancy CE, Eckmann DM, Garbey M, Kassab GS, Lochner DR, McCulloch AD, Tran-Son-Tay R, Trayanova NA. Multi-scale Modeling of the Cardiovascular System: Disease Development, Progression, and Clinical Intervention. Annals of Biomedical Engineering. PMID 27138523 DOI: 10.1007/S10439-016-1628-0 |
0.197 |
|
| 2009 |
Akar FG, Clancy CE. Arrhythmia models: in vivo, in vitro and in silico. Drug Discovery Today. Disease Models. 6: 55-56. PMID 21072326 DOI: 10.1016/j.ddmod.2010.04.001 |
0.194 |
|
| 2019 |
Sato D, Hernández-Hernández G, Matsumoto C, Tajada S, Moreno CM, Dixon RE, O'Dwyer S, Navedo MF, Trimmer JS, Clancy CE, Binder MD, Santana LF. A stochastic model of ion channel cluster formation in the plasma membrane. The Journal of General Physiology. PMID 31371391 DOI: 10.1085/Jgp.201912327 |
0.185 |
|
| 2018 |
DeMarco KR, Bekker S, Clancy CE, Noskov SY, Vorobyov I. Digging into Lipid Membrane Permeation for Cardiac Ion Channel Blocker d-Sotalol with All-Atom Simulations. Frontiers in Pharmacology. 9: 26. PMID 29449809 DOI: 10.3389/Fphar.2018.00026 |
0.181 |
|
| 2021 |
Aghasafari P, Yang PC, Kernik DC, Sakamoto K, Kanda Y, Kurokawa J, Vorobyov I, Clancy CE. A deep learning algorithm to translate and classify cardiac electrophysiology. Elife. 10. PMID 34212860 DOI: 10.7554/eLife.68335 |
0.178 |
|
| 2020 |
DeMarco KR, Yang P, Aghasafari P, Dawson JR, Bekker S, Noskov SY, Yarov-Yarovoy V, Vorobyov I, Clancy CE. Demonstration of a Predictive Multiscale Model for Drug-Induced Arrhythmogenic Risk Biophysical Journal. 118: 325a. DOI: 10.1016/J.Bpj.2019.11.1825 |
0.176 |
|
| 2019 |
Hernandez Hernandez G, Matsumoto C, Moreno CM, Tajada S, Dixon RE, Navedo MF, Binder MD, Clancy CE, Santana LF, Sato D. A Novel Stochastic Self-Assembly Model for Ion Channel Trafficking and Clustering in Excitable Cells Biophysical Journal. 116: 399a. DOI: 10.1016/J.Bpj.2018.11.2156 |
0.171 |
|
| 2020 |
Emigh AM, DeMarco K, Furutani K, Clancy CE, Vorobyov IV, Yarov-Yarovoy V. Predicting Arrhythmogenicity: Structural Modeling of Safe and Unsafe hERG Blockers Biophysical Journal. 118: 117a. DOI: 10.1016/J.Bpj.2019.11.779 |
0.162 |
|
| 2020 |
Gomis-Tena J, Brown BM, Cano J, Trenor B, Yang PC, Saiz J, Clancy CE, Romero L. When Does the IC Accurately Assess the Blocking Potency of a Drug? Journal of Chemical Information and Modeling. PMID 32105478 DOI: 10.1021/Acs.Jcim.9B01085 |
0.154 |
|
| 2020 |
DeMarco KR, Dawson JRD, Bekker S, Yarov-Yarovoy V, Clancy CE, Vorobyov I. SPARC: Atomistic Modeling of Autonomic Stimulation for a Multi‐Scale Neurocardiovascular Simulator. The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07032 |
0.153 |
|
| 2022 |
Mehra R, Tjurmina OA, Ajijola OA, Arora R, Bolser DC, Chapleau MW, Chen PS, Clancy CE, Delisle BP, Gold MR, Goldberger JJ, Goldstein DS, Habecker BA, Handoko ML, Harvey R, et al. Research Opportunities in Autonomic Neural Mechanisms of Cardiopulmonary Regulation: A Report From the National Heart, Lung, and Blood Institute and the National Institutes of Health Office of the Director Workshop. Jacc. Basic to Translational Science. 7: 265-293. PMID 35411324 DOI: 10.1016/j.jacbts.2021.11.003 |
0.15 |
|
| 2023 |
Santana L, Matsumoto C, O'Dwyer S, Manning D, Hernandez-Hernandez G, Rhana P, Fong Z, Sato D, Clancy C, Vierra N, Trimmer J. The formation of KV2.1 macro-clusters is required for sex-specific differences in L-type CaV1.2 clustering and function in arterial myocytes. Research Square. PMID 37502980 DOI: 10.21203/rs.3.rs-3136085/v1 |
0.141 |
|
| 2023 |
Matsumoto C, O'Dwyer SC, Manning D, Hernandez-Hernandez G, Rhana P, Fong Z, Sato D, Clancy CE, Vierra NC, Trimmer JS, Fernando Santana L. The formation of K2.1 macro-clusters is required for sex-specific differences in L-type Ca1.2 clustering and function in arterial myocytes. Communications Biology. 6: 1165. PMID 37963972 DOI: 10.1038/s42003-023-05527-1 |
0.141 |
|
| 2023 |
Matsumoto C, O'Dwyer SC, Manning D, Hernandez-Hernandez G, Rhana P, Fong Z, Sato D, Clancy CE, Vierra NC, Trimmer JS, Santana LF. The formation of K 2.1 macro-clusters is required for sex-specific differences in L-type Ca 1.2 clustering and function in arterial myocytes. Biorxiv : the Preprint Server For Biology. PMID 37425816 DOI: 10.1101/2023.06.27.546725 |
0.141 |
|
| 2019 |
Furutani K, Docken S, Vorobyov IV, Clancy CE, Lewis TJ, Sack JT. A Kinetic Mechanism Underlying hERG Facilitation by a Blocker Biophysical Journal. 116: 245a. DOI: 10.1016/J.Bpj.2018.11.1343 |
0.137 |
|
| 2003 |
Clancy CE, Kass RS. Pharmacogenomics in the treatment of epilepsy. Pharmacogenomics. 4: 747-51. PMID 14596638 DOI: 10.1517/phgs.4.6.747.22822 |
0.136 |
|
| 2019 |
Kernik DC, Morotti S, Priyanka G, Wu JC, Jalife J, Grandi E, Clancy CE. A Computational Approach to Predict Mechanisms of Phenotypic Variability in Induced Pluripotent Stem Cell-Derived Cardiomyocytes Biophysical Journal. 116: 101a. DOI: 10.1016/J.Bpj.2018.11.580 |
0.135 |
|
| 2020 |
DeMarco KR, Dawson JR, Bekker S, Yarov-Yarovoy V, Clancy CE, Vorobyov I. Atomistic Modeling of Neuro-cardiovascular Coupling Modulation Biophysical Journal. 118: 161a. DOI: 10.1016/J.Bpj.2019.11.996 |
0.134 |
|
| 2014 |
Clancy CE, Xiang YK. Biological techniques: Wrapped around the heart. Nature. 507: 43-4. PMID 24598634 DOI: 10.1038/507043a |
0.125 |
|
| 2008 |
Furukawa T, Kurokawa J, Nakamura H, Bai C, Asada K, Tamagawa M, Nakaya H, Vaknin R, Xu J, Clancy CE, Isobe M. Japanese Journal of Electrocardiology. 28: 119-128. DOI: 10.5105/Jse.28.119 |
0.12 |
|
| 2024 |
Clancy CE, Parkash R, Shah M, Tedrow U. Empowering Women in Electrophysiology: Insights on National Women's Heart Day. Jacc. Clinical Electrophysiology. 10: 189-192. PMID 38310490 DOI: 10.1016/j.jacep.2024.01.012 |
0.12 |
|
| 2017 |
Clancy CE. Predictive Computational Pharmacology: From Atom to Rhythm Biophysical Journal. 112: 465a. DOI: 10.1016/j.bpj.2016.11.2495 |
0.116 |
|
| 2018 |
Vorobyov I, Clancy CE. Sex, drugs, and funky rhythms. Heart Rhythm. 15: 485-486. PMID 29605014 DOI: 10.1016/J.Hrthm.2018.01.028 |
0.113 |
|
| 2019 |
Meyer EE, Lewis TJ, Clancy CE. Mechanism for cAMP Overshoot in Ventricular Myocytes Following β1-Adrenergic Stimulation Biophysical Journal. 116: 229a-230a. DOI: 10.1016/J.Bpj.2018.11.1263 |
0.113 |
|
| 2020 |
Clancy CE. High throughput screening in silico via computer models of induced-pluripotent stem cell derived cardiomyocytes Proceedings For Annual Meeting of the Japanese Pharmacological Society. 93: 3-S29-3. DOI: 10.1254/jpssuppl.93.0_3-s29-3 |
0.111 |
|
| 2016 |
Agarwal SR, Clancy CE, Harvey RD. Mechanisms Restricting Diffusion of Intracellular cAMP. Scientific Reports. 6: 19577. PMID 26795432 DOI: 10.1038/srep19577 |
0.11 |
|
| 2005 |
Zhu ZI, Clancy CE. From mutation to clinical presentation: mechanisms in the black box. Journal of Molecular and Cellular Cardiology. 38: 965-8. PMID 15878172 DOI: 10.1016/j.yjmcc.2005.03.011 |
0.107 |
|
| 2019 |
Miranda WE, Duff HJ, Guo J, Vorobyov IV, DeMarco KR, Clancy CE, Yu Noskov S. Molecular Mechanisms of Filter-Level Gating and Loss of Selectivity in hERG1 N629D Mutant from Microseconds MD Simulations Biophysical Journal. 116: 101a. DOI: 10.1016/J.Bpj.2018.11.582 |
0.101 |
|
| 2019 |
DeMarco KR, Dawson JR, Bekker B, Vorobyov IV, Yarov-Yarovoy V, Yu Noskov S, Clancy CE. The Molecular Mechanisms of State Dependent hERG Blockade by Dofetilide Biophysical Journal. 116: 245a. DOI: 10.1016/J.Bpj.2018.11.1341 |
0.1 |
|
| 2020 |
Dawson JR, DeMarco K, Yang P, Bekker S, Yarov-Yarovoy V, Clancy CE, Vorobyov IV. Elucidating the Molecular Determinants of Pro-arrhythmic Proclivities of Beta-blocking Drugs Biophysical Journal. 118: 115a-116a. DOI: 10.1016/J.Bpj.2019.11.774 |
0.096 |
|
| 2018 |
Agarwal SR, Gratwohl J, Cozad M, Yang PC, Clancy CE, Harvey RD. Compartmentalized cAMP Signaling Associated With Lipid Raft and Non-raft Membrane Domains in Adult Ventricular Myocytes. Frontiers in Pharmacology. 9: 332. PMID 29740315 DOI: 10.3389/fphar.2018.00332 |
0.088 |
|
| 2014 |
Agarwal SR, Yang PC, Rice M, Singer CA, Nikolaev VO, Lohse MJ, Clancy CE, Harvey RD. Role of membrane microdomains in compartmentation of cAMP signaling. Plos One. 9: e95835. PMID 24752595 DOI: 10.1371/Journal.Pone.0095835 |
0.086 |
|
| 2023 |
Han Y, Dawson JRD, DeMarco KR, Rouen KC, Bekker S, Yarov-Yarovoy V, Clancy CE, Xiang YK, Vorobyov I. Elucidation of a dynamic interplay between a beta-2 adrenergic receptor, its agonist, and stimulatory G protein. Proceedings of the National Academy of Sciences of the United States of America. 120: e2215916120. PMID 36853938 DOI: 10.1073/pnas.2215916120 |
0.082 |
|
| 2020 |
Clancy CE, Santana LF. Evolving Discovery of the Origin of the Heartbeat: A New Perspective on Sinus Rhythm. Jacc. Clinical Electrophysiology. 6: 932-934. PMID 32819527 DOI: 10.1016/j.jacep.2020.07.002 |
0.078 |
|
| 2016 |
Agarwal SR, Clancy CE, Harvey RD. Restricted Diffusion of cAMP is Mediated by Mitochondrial Localized PKA Buffering in Living Cells Biophysical Journal. 110: 88a-89a. DOI: 10.1016/j.bpj.2015.11.535 |
0.067 |
|
| 1997 |
Clancy CE, Mendoza MG, Naismith TV, Kolman MF, Egelhoff TT. Identification of a protein kinase from Dictyostelium with homology to the novel catalytic domain of myosin heavy chain kinase A Journal of Biological Chemistry. 272: 11812-11815. PMID 9115238 DOI: 10.1074/jbc.272.18.11812 |
0.036 |
|
| 2021 |
Janson CM, Clancy CE. Ivabradine for Postoperative JET: Clear for Take-Off? Jacc. Clinical Electrophysiology. 7: 1061-1063. PMID 34412869 DOI: 10.1016/j.jacep.2021.03.015 |
0.027 |
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