| Year |
Citation |
Score |
| 2024 |
El-Mahrouk SR, El-Ghiaty MA, Alqahtani MA, El-Kadi AOS. Dimethylmonothioarsinic acid (DMMTA) differentially modulates the expression of AHR-regulated cytochrome P450 1A enzymes in vivo and in vitro. Toxicology Letters. 394: 32-45. PMID 38403205 DOI: 10.1016/j.toxlet.2024.02.007 |
0.51 |
|
| 2024 |
Alqahtani MA, El-Ghiaty MA, El-Mahrouk SR, El-Kadi AOS. Differential Modulatory Effects of Methylmercury (MeHg) on Ahr-regulated Genes in Extrahepatic Tissues of C57BL/6 Mice. Biological Trace Element Research. PMID 38197905 DOI: 10.1007/s12011-023-04050-y |
0.513 |
|
| 2023 |
Helal SA, Gerges SH, El-Kadi AOS. Enantioselectivity in some physiological and pathophysiological roles of hydroxyeicosatetraenoic acids. Drug Metabolism Reviews. 56: 31-45. PMID 38358327 DOI: 10.1080/03602532.2023.2284110 |
0.315 |
|
| 2023 |
Hidayat R, El-Ghiaty MA, Shoieb SM, Alqahtani MA, El-Kadi AOS. The Effects of 16-HETE Enantiomers on Hypertrophic Markers in Human Fetal Ventricular Cardiomyocytes, RL-14 Cells. European Journal of Drug Metabolism and Pharmacokinetics. 48: 709-722. PMID 37815672 DOI: 10.1007/s13318-023-00857-1 |
0.357 |
|
| 2023 |
Alqahtani MA, El-Ghiaty MA, El-Mahrouk SR, El-Kadi AOS. Methylmercury (MeHg) transcriptionally regulates NAD(P)H:quinone oxidoreductase 1 (NQO1) in Hepa-1c1c7 cells. Current Research in Toxicology. 5: 100126. PMID 37808441 DOI: 10.1016/j.crtox.2023.100126 |
0.429 |
|
| 2023 |
Hidayat R, Shoieb SM, Mosa FES, Barakat K, Brocks DR, Isse FA, Gerges SH, El-Kadi AOS. 16R-HETE and 16S-HETE alter human cytochrome P450 1B1 enzyme activity probably through an allosteric mechanism. Molecular and Cellular Biochemistry. PMID 37436655 DOI: 10.1007/s11010-023-04801-4 |
0.381 |
|
| 2023 |
El-Ghiaty MA, Alqahtani MA, El-Kadi AOS. Arsenic trioxide (ATO) up-regulates cytochrome P450 1A (CYP1A) enzymes in murine hepatoma Hepa-1c1c7 cell line. Environmental Toxicology and Pharmacology. 101: 104214. PMID 37423394 DOI: 10.1016/j.etap.2023.104214 |
0.375 |
|
| 2023 |
Isse FA, Alammari AH, El-Sherbeni AA, El-Kadi AOS. 17-(R/S)-hydroxyeicosatetraenoic acid (HETE) induces cardiac hypertrophy through the CYP1B1 in enantioselective manners. Prostaglandins & Other Lipid Mediators. 168: 106749. PMID 37244564 DOI: 10.1016/j.prostaglandins.2023.106749 |
0.412 |
|
| 2023 |
Alammari AH, Gerges SH, Isse FA, El-Kadi AOS. 6-Formylindolo[3,2-b]carbazole Protects Against Angiotensin II-Induced Cellular Hypertrophy through the Induction of Cytochrome P450 1A1 and Its Associated 19(S)-HETE Metabolite In Vitro. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 51: 833-843. PMID 37185150 DOI: 10.1124/dmd.123.001267 |
0.451 |
|
| 2023 |
El-Ghiaty MA, Alqahtani MA, El-Kadi AOS. Modulation of cytochrome P450 1A (CYP1A) enzymes by monomethylmonothioarsonic acid (MMMTA) in vivo and in vitro. Chemico-Biological Interactions. 376: 110447. PMID 36893905 DOI: 10.1016/j.cbi.2023.110447 |
0.475 |
|
| 2022 |
Alqahtani MA, El-Ghiaty MA, El-Kadi AOS. Mercury and methylmercury differentially modulate hepatic cytochrome P450 1A1 and 1A2 in vivo and in vitro. Journal of Biochemical and Molecular Toxicology. e23243. PMID 36245390 DOI: 10.1002/jbt.23243 |
0.452 |
|
| 2022 |
Gerges SH, El-Kadi AOS. . Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 36116791 DOI: 10.1124/dmd.122.000915 |
0.323 |
|
| 2022 |
El-Ghiaty MA, Alqahtani MA, El-Kadi AOS. Down-regulation of hepatic cytochromes P450 1A1 and 1A2 by arsenic trioxide (ATO) in vivo and in vitro: A role of heme oxygenase 1. Chemico-Biological Interactions. 364: 110049. PMID 35872050 DOI: 10.1016/j.cbi.2022.110049 |
0.415 |
|
| 2022 |
Shoieb SM, Alammari AH, Levasseur J, Silver H, Dyck JRB, El-Kadi AOS. Ameliorative Role of Fluconazole against Abdominal Aortic Constriction-Induced Cardiac Hypertrophy in Rats. Journal of Cardiovascular Pharmacology. PMID 35266922 DOI: 10.1097/FJC.0000000000001258 |
0.376 |
|
| 2021 |
Shoieb SM, Dakarapu R, Falck JR, El-Kadi AOS. Novel Synthetic Analogues of 19(S/R)-Hydroxyeicosatetraenoic Acid Exhibit Noncompetitive Inhibitory Effect on the Activity of Cytochrome P450 1A1 and 1B1. European Journal of Drug Metabolism and Pharmacokinetics. PMID 34235626 DOI: 10.1007/s13318-021-00699-9 |
0.33 |
|
| 2020 |
Shoieb SM, El-Kadi AOS. Resveratrol attenuates angiotensin II-induced cellular hypertrophy through the inhibition of CYP1B1 and the cardiotoxic mid-chain HETE metabolites. Molecular and Cellular Biochemistry. PMID 32533462 DOI: 10.1007/s11010-020-03777-9 |
0.352 |
|
| 2020 |
Alammari AH, Shoieb SM, Maayah ZH, El-Kadi AOS. Fluconazole Represses Cytochrome P450 1B1 and its Associated Arachidonic Acid Metabolites in the Heart and Protects Against Angiotensin II-Induced Cardiac Hypertrophy. Journal of Pharmaceutical Sciences. PMID 32240690 DOI: 10.1016/j.xphs.2020.03.016 |
0.383 |
|
| 2019 |
Al Nebaihi HM, Al Batran R, Ussher JR, Maayah ZH, El-Kadi AOS, Brocks DR. Dietary-induced obesity, hepatic cytochrome P450 and lidocaine metabolism: Comparative effects of high-fat diets in mice and rats and reversibility of effects with normalization of diet. Journal of Pharmaceutical Sciences. PMID 31733268 DOI: 10.1016/j.xphs.2019.11.007 |
0.317 |
|
| 2018 |
Shoieb SM, El-Sherbeni AA, El-Kadi AOS. Subterminal hydroxyeicosatetraenoic acids: Crucial lipid mediators in normal physiology and disease states. Chemico-Biological Interactions. 299: 140-150. PMID 30543782 DOI: 10.1016/j.cbi.2018.12.004 |
0.324 |
|
| 2018 |
Matsumura N, Takahara S, Maayah ZH, Parajuli N, Byrne NJ, Shoieb SM, Soltys CM, Beker DL, Masson G, El-Kadi AOS, Dyck JRB. Resveratrol improves cardiac function and exercise performance in MI-induced heart failure through the inhibition of cardiotoxic HETE metabolites. Journal of Molecular and Cellular Cardiology. PMID 30381233 DOI: 10.1016/j.yjmcc.2018.10.023 |
0.337 |
|
| 2018 |
Shoieb SM, El-Kadi AOS. S-Enantiomer of 19-Hydroxyeicosatetraenoic Acid Preferentially Protects Against Angiotensin II-Induced Cardiac Hypertrophy. Drug Metabolism and Disposition: the Biological Fate of Chemicals. PMID 29880629 DOI: 10.1124/dmd.118.082073 |
0.323 |
|
| 2018 |
Maayah ZH, Levasseur J, Siva Piragasam R, Abdelhamid G, Dyck JRB, Fahlman RP, Siraki AG, El-Kadi AOS. 2-Methoxyestradiol protects against pressure overload-induced left ventricular hypertrophy. Scientific Reports. 8: 2780. PMID 29426916 DOI: 10.1038/S41598-018-20613-9 |
0.353 |
|
| 2017 |
Maayah ZH, Abdelhamid G, Elshenawy OH, El-Sherbeni AA, Althurwi HN, McGinn E, Dawood D, Alammari AH, El-Kadi AOS. The Role of Soluble Epoxide Hydrolase Enzyme on Daunorubicin-Mediated Cardiotoxicity. Cardiovascular Toxicology. PMID 29196978 DOI: 10.1007/s12012-017-9437-8 |
0.5 |
|
| 2017 |
Alrushaid S, Zhao Y, Sayre CL, Maayah ZH, Laird Forrest M, Senadheera SN, Chaboyer K, Anderson HD, El-Kadi AOS, Davies NM. Mechanistically elucidating the in vitro safety and efficacy of a novel doxorubicin derivative. Drug Delivery and Translational Research. PMID 28462502 DOI: 10.1007/S13346-017-0379-2 |
0.323 |
|
| 2017 |
Elkhatali S, Maayah ZH, El-Sherbeni AA, Elshenawy OH, Abdelhamid G, Shoieb SM, El-Kadi AOS. Inhibition of Mid-chain HETEs Protects Against Angiotensin II-Induced Cardiac Hypertrophy. Journal of Cardiovascular Pharmacology. PMID 28437282 DOI: 10.1097/FJC.0000000000000494 |
0.322 |
|
| 2017 |
Maayah ZH, Althurwi HN, El-Sherbeni AA, Abdelhamid G, Siraki AG, El-Kadi AO. The role of cytochrome P450 1B1 and its associated mid-chain hydroxyeicosatetraenoic acid metabolites in the development of cardiac hypertrophy induced by isoproterenol. Molecular and Cellular Biochemistry. PMID 28251434 DOI: 10.1007/s11010-017-2943-y |
0.42 |
|
| 2017 |
Elshenawy OH, Abdelhamid G, Soshilov AA, Denison MS, El-Kadi AO. DOWN-REGULATION OF CYTOCHROME P450 1A1 BY MONOMETHYLARSONOUS ACID IN HUMAN HEPG2 CELLS. Toxicology Letters. PMID 28189647 DOI: 10.1016/J.Toxlet.2017.02.012 |
0.417 |
|
| 2017 |
Elshenawy OH, Abdelhamid G, Althurwi HN, El-Kadi AO. Dimethylarsinic acid modulates the aryl hydrocarbon receptor regulated genes in C57BL/6 mice: in vivo study. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 1-36. PMID 28134025 DOI: 10.1080/00498254.2017.1289423 |
0.469 |
|
| 2016 |
Gabr RQ, El-Sherbeni AA, Ben-Eltriki M, El-Kadi AO, Brocks DR. Pharmacokinetics of metformin in the rat: Assessment of the effect of hyperlipidemia and evidence for its metabolism to guanylurea. Canadian Journal of Physiology and Pharmacology. PMID 28177686 DOI: 10.1139/cjpp-2016-0329 |
0.328 |
|
| 2016 |
El-Sherbeni AA, El-Kadi AO. Microsomal Cytochrome P450 as a Target for Drug Discovery and Repurposing. Drug Metabolism Reviews. 1-40. PMID 27819488 DOI: 10.1080/03602532.2016.1257021 |
0.302 |
|
| 2016 |
El-Sherbeni AA, El-Kadi AO. Repurposing Resveratrol and Fluconazole To Modulate Human Cytochrome P450-Mediated Arachidonic Acid Metabolism. Molecular Pharmaceutics. 13: 1278-88. PMID 26918316 DOI: 10.1021/acs.molpharmaceut.5b00873 |
0.36 |
|
| 2016 |
Anwar-Mohamed A, El-Sherbeni AA, Hamdy DA, Korashy HM, Brocks DR, El-Kadi AO. Ketoconazole Stereoisomers Differentially Induce Cytochrome P450 1A1 Between Human Hepatoma HepG2 and Mouse Hepatoma Hepa1c1c7 Cells. Journal of Pharmaceutical Sciences. 105: 1318-26. PMID 26886340 DOI: 10.1016/j.xphs.2015.12.009 |
0.302 |
|
| 2016 |
Maayah ZH, Althurwi HN, Abdelhamid G, Lesyk G, Jurasz P, El-Kadi AO. CYP1B1 inhibition attenuates doxorubicin-induced cardiotoxicity through a mid-chain HETEs-dependent mechanism. Pharmacological Research. 105: 28-43. PMID 26772815 DOI: 10.1016/j.phrs.2015.12.016 |
0.342 |
|
| 2016 |
Maayah ZH, El-Kadi AO. The role of mid-chain hydroxyeicosatetraenoic acids in the pathogenesis of hypertension and cardiac hypertrophy. Archives of Toxicology. 90: 119-36. PMID 26525395 DOI: 10.1007/s00204-015-1620-8 |
0.314 |
|
| 2016 |
Maayah ZH, El-Kadi AO. 5-, 12- and 15-Hydroxyeicosatetraenoic acids induce cellular hypertrophy in the human ventricular cardiomyocyte, RL-14 cell line, through MAPK- and NF-κB-dependent mechanism. Archives of Toxicology. 90: 359-73. PMID 25600587 DOI: 10.1007/s00204-014-1419-z |
0.303 |
|
| 2015 |
Maayah ZH, Abdelhamid G, El-Kadi AO. Development of cellular hypertrophy by 8-hydroxyeicosatetraenoic acid in the human ventricular cardiomyocyte, RL-14 cell line, is implicated by MAPK and NF-κB. Cell Biology and Toxicology. 31: 241-59. PMID 26493311 DOI: 10.1007/s10565-015-9308-7 |
0.349 |
|
| 2015 |
Elkhatali S, El-Sherbeni AA, Elshenawy OH, Abdelhamid G, El-Kadi AO. 19-Hydroxyeicosatetraenoic acid and isoniazid protect against angiotensin II-induced cardiac hypertrophy. Toxicology and Applied Pharmacology. 289: 550-9. PMID 26454030 DOI: 10.1016/j.taap.2015.10.003 |
0.338 |
|
| 2015 |
Elshenawy OH, El-Kadi AO. Modulation of aryl hydrocarbon receptor-regulated enzymes by trimethylarsine oxide in C57BL/6 mice: In vivo and in vitro studies. Toxicology Letters. 238: 17-31. PMID 26144063 DOI: 10.1016/j.toxlet.2015.06.1646 |
0.471 |
|
| 2015 |
Elshenawy OH, El-Kadi AO. Modulation of aryl hydrocarbon receptor regulated genes by acute administration of trimethylarsine oxide in the lung, kidney and heart of C57BL/6 mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 45: 930-43. PMID 26042454 DOI: 10.3109/00498254.2015.1032385 |
0.441 |
|
| 2015 |
Althurwi HN, Maayah ZH, Elshenawy OH, El-Kadi AO. Early Changes in Cytochrome P450s and Their Associated Arachidonic Acid Metabolites Play a Crucial Role in the Initiation of Cardiac Hypertrophy Induced by Isoproterenol. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 43: 1254-66. PMID 26033621 DOI: 10.1124/dmd.115.063776 |
0.451 |
|
| 2015 |
Abdelhamid G, El-Kadi AO. Buthionine sulfoximine, an inhibitor of glutathione biosynthesis, induces expression of soluble epoxide hydrolase and markers of cellular hypertrophy in a rat cardiomyoblast cell line: roles of the NF-κB and MAPK signaling pathways. Free Radical Biology & Medicine. 82: 1-12. PMID 25614461 DOI: 10.1016/j.freeradbiomed.2015.01.005 |
0.371 |
|
| 2015 |
Maayah ZH, Elshenawy OH, Althurwi HN, Abdelhamid G, El-Kadi AO. Human fetal ventricular cardiomyocyte, RL-14 cell line, is a promising model to study drug metabolizing enzymes and their associated arachidonic acid metabolites. Journal of Pharmacological and Toxicological Methods. 71: 33-41. PMID 25454080 DOI: 10.1016/j.vascn.2014.11.005 |
0.342 |
|
| 2014 |
El-Sherbeni AA, El-Kadi AO. The role of epoxide hydrolases in health and disease. Archives of Toxicology. 88: 2013-32. PMID 25248500 DOI: 10.1007/s00204-014-1371-y |
0.333 |
|
| 2014 |
Anwar-Mohamed A, Elshenawy OH, El-Sherbeni AA, Abdelrady M, El-Kadi AO. Acute arsenic treatment alters arachidonic acid and its associated metabolite levels in the brain of C57Bl/6 mice. Canadian Journal of Physiology and Pharmacology. 92: 693-702. PMID 25065748 DOI: 10.1139/cjpp-2014-0136 |
0.309 |
|
| 2014 |
El-Sherbeni AA, El-Kadi AO. Characterization of arachidonic acid metabolism by rat cytochrome P450 enzymes: the involvement of CYP1As. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 42: 1498-507. PMID 24969701 DOI: 10.1124/dmd.114.057836 |
0.43 |
|
| 2014 |
Amara IE, Elshenawy OH, Abdelrady M, El-Kadi AO. Acute mercury toxicity modulates cytochrome P450, soluble epoxide hydrolase and their associated arachidonic acid metabolites in C57Bl/6 mouse heart. Toxicology Letters. 226: 53-62. PMID 24472606 DOI: 10.1016/j.toxlet.2014.01.025 |
0.846 |
|
| 2014 |
El-Sherbeni AA, El-Kadi AO. Alterations in cytochrome P450-derived arachidonic acid metabolism during pressure overload-induced cardiac hypertrophy. Biochemical Pharmacology. 87: 456-66. PMID 24300133 DOI: 10.1016/j.bcp.2013.11.015 |
0.421 |
|
| 2014 |
Anwar-Mohamed A, Elshenawy OH, Soshilov AA, Denison MS, Chris Le X, Klotz LO, El-Kadi AO. Methylated pentavalent arsenic metabolites are bifunctional inducers, as they induce cytochrome P450 1A1 and NAD(P)H:quinone oxidoreductase through AhR- and Nrf2-dependent mechanisms. Free Radical Biology & Medicine. 67: 171-87. PMID 24161444 DOI: 10.1016/J.Freeradbiomed.2013.10.810 |
0.435 |
|
| 2014 |
Althurwi HN, Elshenawy OH, El-Kadi AO. Fenofibrate modulates cytochrome P450 and arachidonic acid metabolism in the heart and protects against isoproterenol-induced cardiac hypertrophy. Journal of Cardiovascular Pharmacology. 63: 167-77. PMID 24157956 DOI: 10.1097/FJC.0000000000000036 |
0.441 |
|
| 2013 |
Gordon M, El-Kalla M, Zhao Y, Fiteih Y, Law J, Volodko N, Anwar-Mohamed A, Mohamed A, El-Kadi AO, Liu L, Odenbach J, Thiesen A, Onyskiw C, Ghazaleh HA, Park J, et al. The tumor suppressor gene, RASSF1A, is essential for protection against inflammation -induced injury. Plos One. 8: e75483. PMID 24146755 DOI: 10.1371/Journal.Pone.0075483 |
0.319 |
|
| 2013 |
Elshenawy OH, Anwar-Mohamed A, El-Kadi AO. 20-Hydroxyeicosatetraenoic acid is a potential therapeutic target in cardiovascular diseases. Current Drug Metabolism. 14: 706-19. PMID 23701160 |
0.305 |
|
| 2013 |
Alsaad AM, Zordoky BN, Tse MM, El-Kadi AO. Role of cytochrome P450-mediated arachidonic acid metabolites in the pathogenesis of cardiac hypertrophy. Drug Metabolism Reviews. 45: 173-95. PMID 23600686 DOI: 10.3109/03602532.2012.754460 |
0.696 |
|
| 2013 |
Amara IE, Anwar-Mohamed A, El-Kadi AO. Posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by methylmercury in HepG2 cells: a role of heme oxygenase-1. Toxicology Letters. 219: 239-47. PMID 23541843 DOI: 10.1016/j.toxlet.2013.03.018 |
0.829 |
|
| 2013 |
El Gendy MA, El-Kadi AO. Harmine and harmaline downregulate TCDD-induced Cyp1a1 in the livers and lungs of C57BL/6 mice. Biomed Research International. 2013: 258095. PMID 23509697 DOI: 10.1155/2013/258095 |
0.386 |
|
| 2013 |
Tse MM, Aboutabl ME, Althurwi HN, Elshenawy OH, Abdelhamid G, El-Kadi AO. Cytochrome P450 epoxygenase metabolite, 14,15-EET, protects against isoproterenol-induced cellular hypertrophy in H9c2 rat cell line. Vascular Pharmacology. 58: 363-73. PMID 23466634 DOI: 10.1016/J.Vph.2013.02.004 |
0.784 |
|
| 2013 |
Abdelhamid G, Amara IE, Anwar-Mohamed A, El-Kadi AO. Modulation of cytochrome P450 1 (Cyp1) by vanadium in hepatic tissue and isolated hepatocyte of C57BL/6 mice. Archives of Toxicology. 87: 1531-43. PMID 23423713 DOI: 10.1007/s00204-013-1023-7 |
0.809 |
|
| 2013 |
Anwar-Mohamed A, El-Sherbeni A, Kim SH, Elshenawy OH, Althurwi HN, Zordoky BN, El-Kadi AO. Acute arsenic treatment alters cytochrome P450 expression and arachidonic acid metabolism in lung, liver and kidney of C57Bl/6 mice. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 43: 719-29. PMID 23409951 DOI: 10.3109/00498254.2012.754113 |
0.722 |
|
| 2013 |
Ansari MA, Maayah ZH, Bakheet SA, El-Kadi AO, Korashy HM. The role of aryl hydrocarbon receptor signaling pathway in cardiotoxicity of acute lead intoxication in vivo and in vitro rat model. Toxicology. 306: 40-9. PMID 23391631 DOI: 10.1016/J.Tox.2013.01.024 |
0.406 |
|
| 2013 |
Anwar-Mohamed A, Abdelhamid G, Amara IE, El-Kadi AO. Differential modulation of cytochrome P450 1a1 by arsenite in vivo and in vitro in C57BL/6 mice. Free Radical Biology & Medicine. 58: 52-63. PMID 23369756 DOI: 10.1016/j.freeradbiomed.2013.01.012 |
0.82 |
|
| 2013 |
Maayah ZH, El Gendy MA, El-Kadi AO, Korashy HM. Sunitinib, a tyrosine kinase inhibitor, induces cytochrome P450 1A1 gene in human breast cancer MCF7 cells through ligand-independent aryl hydrocarbon receptor activation. Archives of Toxicology. 87: 847-56. PMID 23288144 DOI: 10.1007/s00204-012-0996-y |
0.384 |
|
| 2013 |
Elshenawy OH, Anwar-Mohamed A, Abdelhamid G, El-Kadi AO. Murine atrial HL-1 cell line is a reliable model to study drug metabolizing enzymes in the heart. Vascular Pharmacology. 58: 326-33. PMID 23268359 DOI: 10.1016/j.vph.2012.12.002 |
0.464 |
|
| 2013 |
Amara IE, Anwar-Mohamed A, Abdelhamid G, El-Kadi AO. Mercury modulates the cytochrome P450 1a1, 1a2 and 1b1 in C57BL/6J mice: in vivo and in vitro studies. Toxicology and Applied Pharmacology. 266: 419-29. PMID 23231920 DOI: 10.1016/j.taap.2012.11.027 |
0.818 |
|
| 2013 |
Althurwi HN, Tse MM, Abdelhamid G, Zordoky BN, Hammock BD, El-Kadi AO. Soluble epoxide hydrolase inhibitor, TUPS, protects against isoprenaline-induced cardiac hypertrophy. British Journal of Pharmacology. 168: 1794-807. PMID 23176298 DOI: 10.1111/Bph.12066 |
0.72 |
|
| 2013 |
El-Sherbeni AA, Aboutabl ME, Zordoky BN, Anwar-Mohamed A, El-Kadi AO. Determination of the dominant arachidonic acid cytochrome p450 monooxygenases in rat heart, lung, kidney, and liver: protein expression and metabolite kinetics. The Aaps Journal. 15: 112-22. PMID 23139020 DOI: 10.1208/S12248-012-9425-7 |
0.82 |
|
| 2013 |
Brocks DR, Hamdy DA, Ben-Eltriki M, Patel JP, El-Kadi AOS. Effect of rat serum lipoproteins on mRNA levels and amiodarone metabolism by cultured primary rat hepatocytes Journal of Pharmaceutical Sciences. 102: 262-270. PMID 23132435 DOI: 10.1002/jps.23348 |
0.327 |
|
| 2013 |
Chaudhary KR, Zordoky BN, Edin ML, Alsaleh N, El-Kadi AO, Zeldin DC, Seubert JM. Differential effects of soluble epoxide hydrolase inhibition and CYP2J2 overexpression on postischemic cardiac function in aged mice. Prostaglandins & Other Lipid Mediators. 104: 8-17. PMID 22922020 DOI: 10.1016/j.prostaglandins.2012.08.001 |
0.665 |
|
| 2013 |
Abdelhamid G, Amara IE, Anwar-Mohamed A, El-Kadi AO. Modulation of aryl hydrocarbon receptor-regulated genes by acute administration of ammonium metavanadate in kidney, lung and heart of C57BL/6 mice. Journal of Applied Toxicology : Jat. 33: 1230-40. PMID 22611038 DOI: 10.1002/jat.2774 |
0.833 |
|
| 2012 |
Hanafy S, El-Kadi AO, Jamali F. Effect of inflammation on molecular targets and drug transporters. Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society For Pharmaceutical Sciences, SociéTé Canadienne Des Sciences Pharmaceutiques. 15: 361-75. PMID 22974786 |
0.328 |
|
| 2012 |
Alsaad AM, Zordoky BN, El-Sherbeni AA, El-Kadi AO. Chronic doxorubicin cardiotoxicity modulates cardiac cytochrome P450-mediated arachidonic acid metabolism in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 2126-35. PMID 22867862 DOI: 10.1124/dmd.112.046631 |
0.774 |
|
| 2012 |
Anwar-Mohamed A, El-Sherbeni AA, Kim SH, Althurwi HN, Zordoky BN, El-Kadi AO. Acute arsenic toxicity alters cytochrome P450 and soluble epoxide hydrolase and their associated arachidonic acid metabolism in C57Bl/6 mouse heart. Xenobiotica; the Fate of Foreign Compounds in Biological Systems. 42: 1235-47. PMID 22680237 DOI: 10.3109/00498254.2012.693971 |
0.779 |
|
| 2012 |
Amara IE, Anwar-Mohamed A, Abdelhamid G, El-Kadi AO. Effect of mercury on aryl hydrocarbon receptor-regulated genes in the extrahepatic tissues of C57BL/6 mice. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 50: 2325-34. PMID 22579925 DOI: 10.1016/j.fct.2012.04.028 |
0.82 |
|
| 2012 |
Korashy HM, El Gendy MA, Alhaider AA, El-Kadi AO. Camel milk modulates the expression of aryl hydrocarbon receptor-regulated genes, Cyp1a1, Nqo1, and Gsta1, in murine hepatoma Hepa 1c1c7 cells. Journal of Biomedicine & Biotechnology. 2012: 782642. PMID 22570534 DOI: 10.1155/2012/782642 |
0.412 |
|
| 2012 |
Anwar-Mohamed A, Abdelhamid G, Amara IE, El-Kadi AO. Differential modulation of aryl hydrocarbon receptor regulated enzymes by arsenite in the kidney, lung, and heart of C57BL/6 mice. Archives of Toxicology. 86: 897-910. PMID 22535251 DOI: 10.1007/s00204-012-0855-x |
0.825 |
|
| 2012 |
Anwar-Mohamed A, Klotz LO, El-Kadi AO. Inhibition of heme oxygenase-1 partially reverses the arsenite-mediated decrease of CYP1A1, CYP1A2, CYP3A23, and CYP3A2 catalytic activity in isolated rat hepatocytes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 40: 504-14. PMID 22159698 DOI: 10.1124/dmd.111.042564 |
0.47 |
|
| 2012 |
Korashy HM, El-Kadi AO. Transcriptional and posttranslational mechanisms modulating the expression of the cytochrome P450 1A1 gene by lead in HepG2 cells: a role of heme oxygenase. Toxicology. 291: 113-21. PMID 22120038 DOI: 10.1016/j.tox.2011.11.006 |
0.473 |
|
| 2012 |
El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO. Harmaline and harmalol inhibit the carcinogen-activating enzyme CYP1A1 via transcriptional and posttranslational mechanisms. Food and Chemical Toxicology : An International Journal Published For the British Industrial Biological Research Association. 50: 353-62. PMID 22037238 DOI: 10.1016/J.Fct.2011.10.052 |
0.404 |
|
| 2012 |
El Gendy MA, Soshilov AA, Denison MS, El-Kadi AO. Transcriptional and posttranslational inhibition of dioxin-mediated induction of CYP1A1 by harmine and harmol. Toxicology Letters. 208: 51-61. PMID 22001777 DOI: 10.1016/J.Toxlet.2011.09.030 |
0.424 |
|
| 2011 |
Amara IE, El-Kadi AO. Transcriptional modulation of the NAD(P)H:quinone oxidoreductase 1 by mercury in human hepatoma HepG2 cells. Free Radical Biology & Medicine. 51: 1675-85. PMID 21843634 DOI: 10.1016/j.freeradbiomed.2011.07.021 |
0.828 |
|
| 2011 |
Korashy HM, Anwar-Mohamed A, Soshilov AA, Denison MS, El-Kadi AO. The p38 MAPK inhibitor SB203580 induces cytochrome P450 1A1 gene expression in murine and human hepatoma cell lines through ligand-dependent aryl hydrocarbon receptor activation. Chemical Research in Toxicology. 24: 1540-8. PMID 21732638 DOI: 10.1021/Tx200141P |
0.459 |
|
| 2011 |
Zordoky BN, Anwar-Mohamed A, Aboutabl ME, El-Kadi AO. Acute doxorubicin toxicity differentially alters cytochrome P450 expression and arachidonic acid metabolism in rat kidney and liver. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 39: 1440-50. PMID 21571947 DOI: 10.1124/Dmd.111.039123 |
0.83 |
|
| 2011 |
Aboutabl ME, Zordoky BN, Hammock BD, El-Kadi AO. Inhibition of soluble epoxide hydrolase confers cardioprotection and prevents cardiac cytochrome P450 induction by benzo(a)pyrene. Journal of Cardiovascular Pharmacology. 57: 273-81. PMID 21383588 DOI: 10.1097/Fjc.0B013E3182055Baf |
0.822 |
|
| 2011 |
Anwar-Mohamed A, Degenhardt OS, El Gendy MA, Seubert JM, Kleeberger SR, El-Kadi AO. The effect of Nrf2 knockout on the constitutive expression of drug metabolizing enzymes and transporters in C57Bl/6 mice livers. Toxicology in Vitro : An International Journal Published in Association With Bibra. 25: 785-95. PMID 21281708 DOI: 10.1016/j.tiv.2011.01.014 |
0.338 |
|
| 2011 |
Alhaider AA, El Gendy MA, Korashy HM, El-Kadi AO. Camel urine inhibits the cytochrome P450 1a1 gene expression through an AhR-dependent mechanism in Hepa 1c1c7 cell line. Journal of Ethnopharmacology. 133: 184-90. PMID 20883769 DOI: 10.1016/j.jep.2010.09.012 |
0.305 |
|
| 2010 |
Amara IE, Anwar-Mohamed A, El-Kadi AO. Mercury modulates the CYP1A1 at transcriptional and posttranslational levels in human hepatoma HepG2 cells. Toxicology Letters. 199: 225-33. PMID 20837117 DOI: 10.1016/j.toxlet.2010.09.003 |
0.829 |
|
| 2010 |
El Gendy MA, El-Kadi AO. Harman induces CYP1A1 enzyme through an aryl hydrocarbon receptor mechanism. Toxicology and Applied Pharmacology. 249: 55-64. PMID 20732341 DOI: 10.1016/j.taap.2010.08.014 |
0.448 |
|
| 2010 |
Abdelhamid G, Anwar-Mohamed A, Elmazar MM, El-Kadi AO. Modulation of NAD(P)H:quinone oxidoreductase by vanadium in human hepatoma HepG2 cells. Toxicology in Vitro : An International Journal Published in Association With Bibra. 24: 1554-61. PMID 20599494 DOI: 10.1016/j.tiv.2010.06.017 |
0.364 |
|
| 2010 |
Elsherbiny ME, El-Kadi AO, Brocks DR. The effect of beta-naphthoflavone on the metabolism of amiodarone by hepatic and extra-hepatic microsomes. Toxicology Letters. 195: 147-54. PMID 20362646 DOI: 10.1016/j.toxlet.2010.03.019 |
0.366 |
|
| 2010 |
Abdelhamid G, Anwar-Mohamed A, Badary OA, Moustafa AA, El-Kadi AO. Transcriptional and posttranscriptional regulation of CYP1A1 by vanadium in human hepatoma HepG2 cells. Cell Biology and Toxicology. 26: 421-34. PMID 20221682 DOI: 10.1007/s10565-010-9153-7 |
0.406 |
|
| 2010 |
Anwar-Mohamed A, El-Kadi AO. Arsenite down-regulates cytochrome P450 1A1 at the transcriptional and posttranslational levels in human HepG2 cells. Free Radical Biology & Medicine. 48: 1399-409. PMID 20188822 DOI: 10.1016/j.freeradbiomed.2010.02.027 |
0.453 |
|
| 2010 |
Zordoky BN, El-Kadi AO. Effect of cytochrome P450 polymorphism on arachidonic acid metabolism and their impact on cardiovascular diseases. Pharmacology & Therapeutics. 125: 446-63. PMID 20093140 DOI: 10.1016/j.pharmthera.2009.12.002 |
0.69 |
|
| 2010 |
Anwar-mohamed A, Zordoky BN, Aboutabl ME, El-Kadi AO. Alteration of cardiac cytochrome P450-mediated arachidonic acid metabolism in response to lipopolysaccharide-induced acute systemic inflammation. Pharmacological Research. 61: 410-8. PMID 20045729 DOI: 10.1016/J.Phrs.2009.12.015 |
0.837 |
|
| 2010 |
Zordoky BN, El-Kadi AO. 2,3,7,8-Tetrachlorodibenzo-p-dioxin and beta-naphthoflavone induce cellular hypertrophy in H9c2 cells by an aryl hydrocarbon receptor-dependant mechanism. Toxicology in Vitro : An International Journal Published in Association With Bibra. 24: 863-71. PMID 19969063 DOI: 10.1016/j.tiv.2009.12.002 |
0.722 |
|
| 2010 |
El Gendy MA, Somayaji V, El-Kadi AO. Peganum harmala L. is a candidate herbal plant for preventing dioxin mediated effects. Planta Medica. 76: 671-7. PMID 19941261 DOI: 10.1055/s-0029-1240633 |
0.342 |
|
| 2010 |
Zordoky BN, Anwar-Mohamed A, Aboutabl ME, El-Kadi AO. Acute doxorubicin cardiotoxicity alters cardiac cytochrome P450 expression and arachidonic acid metabolism in rats. Toxicology and Applied Pharmacology. 242: 38-46. PMID 19796650 DOI: 10.1016/J.Taap.2009.09.012 |
0.835 |
|
| 2010 |
Anwar-Mohamed A, El-Kadi AO. Inhibition of Heme Oxygenase-1 Partially Reverses the Arsenite-mediated Decrease of Cytochrome P450 1A1 (CYP1A1), CYP1A2, CYP3A23, and CYP3A2 Catalytic Activity in Isolated Rat Hepatocytes Free Radical Biology and Medicine. 49: S87. DOI: 10.1016/j.freeradbiomed.2010.10.219 |
0.353 |
|
| 2010 |
Zordoky B, El-Kadi A. Acute Doxorubicin Toxicity Differentially Alters Cytochrome P450 Expression in the Kidney and Liver of Male Sprague Dawley Rats Free Radical Biology and Medicine. 49: S75. DOI: 10.1016/J.Freeradbiomed.2010.10.187 |
0.718 |
|
| 2009 |
El Gendy MA, El-Kadi AO. Peganum harmala L. differentially modulates cytochrome P450 gene expression in human hepatoma HepG2 cells. Drug Metabolism Letters. 3: 212-6. PMID 20041830 |
0.332 |
|
| 2009 |
Aboutabl ME, Zordoky BN, El-Kadi AO. 3-methylcholanthrene and benzo(a)pyrene modulate cardiac cytochrome P450 gene expression and arachidonic acid metabolism in male Sprague Dawley rats. British Journal of Pharmacology. 158: 1808-19. PMID 19889059 DOI: 10.1111/J.1476-5381.2009.00461.X |
0.814 |
|
| 2009 |
Anwar-Mohamed A, El-Kadi AO. Down-regulation of the detoxifying enzyme NAD(P)H:quinone oxidoreductase 1 by vanadium in Hepa 1c1c7 cells. Toxicology and Applied Pharmacology. 236: 261-9. PMID 19367690 |
0.403 |
|
| 2009 |
Zordoky BN, El-Kadi AO. Role of NF-kappaB in the regulation of cytochrome P450 enzymes. Current Drug Metabolism. 10: 164-78. PMID 19275551 DOI: 10.2174/138920009787522151 |
0.684 |
|
| 2009 |
Anwar-Mohamed A, El-Kadi AO. Sulforaphane induces CYP1A1 mRNA, protein, and catalytic activity levels via an AhR-dependent pathway in murine hepatoma Hepa 1c1c7 and human HepG2 cells. Cancer Letters. 275: 93-101. PMID 19013013 DOI: 10.1016/j.canlet.2008.10.003 |
0.435 |
|
| 2008 |
Anwar-Mohamed A, Elbekai RH, El-Kadi AO. MG-132 inhibits the TCDD-mediated induction of Cyp1a1 at the catalytic activity but not the mRNA or protein levels in Hepa 1c1c7 cells. Toxicology Letters. 182: 121-6. PMID 18835339 DOI: 10.1016/j.toxlet.2008.09.007 |
0.386 |
|
| 2008 |
Zordoky BN, Aboutabl ME, El-Kadi AO. Modulation of cytochrome P450 gene expression and arachidonic acid metabolism during isoproterenol-induced cardiac hypertrophy in rats. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 2277-86. PMID 18725507 DOI: 10.1124/Dmd.108.023077 |
0.838 |
|
| 2008 |
Zordoky BN, El-Kadi AO. Induction of several cytochrome P450 genes by doxorubicin in H9c2 cells. Vascular Pharmacology. 49: 166-72. PMID 18707023 DOI: 10.1016/j.vph.2008.07.004 |
0.733 |
|
| 2008 |
Shayeganpour A, Korashy H, Patel JP, El-Kadi AO, Brocks DR. The impact of experimental hyperlipidemia on the distribution and metabolism of amiodarone in rat. International Journal of Pharmaceutics. 361: 78-86. PMID 18599227 DOI: 10.1016/j.ijpharm.2008.05.019 |
0.311 |
|
| 2008 |
Anwar-Mohamed A, El-Kadi AO. Down-regulation of the carcinogen-metabolizing enzyme cytochrome P450 1a1 by vanadium. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 36: 1819-27. PMID 18541696 DOI: 10.1124/dmd.108.021154 |
0.414 |
|
| 2008 |
Elbekai RH, El-Kadi AO. Arsenite and cadmium, but not chromium, induce NAD(P)H:quinone oxidoreductase 1 through transcriptional mechanisms, in spite of post-transcriptional modifications. Toxicology in Vitro : An International Journal Published in Association With Bibra. 22: 1184-90. PMID 18474416 DOI: 10.1016/j.tiv.2008.03.010 |
0.334 |
|
| 2008 |
Zordoky BN, El-Kadi AO. Modulation of cardiac and hepatic cytochrome P450 enzymes during heart failure. Current Drug Metabolism. 9: 122-8. PMID 18288954 |
0.708 |
|
| 2008 |
Korashy HM, El-Kadi AO. The role of redox-sensitive transcription factors NF-kappaB and AP-1 in the modulation of the Cyp1a1 gene by mercury, lead, and copper. Free Radical Biology & Medicine. 44: 795-806. PMID 18078826 DOI: 10.1016/j.freeradbiomed.2007.11.003 |
0.305 |
|
| 2007 |
Korashy HM, Brocks DR, El-Kadi AO. Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection. Cancer Letters. 258: 135-43. PMID 17923278 DOI: 10.1016/j.canlet.2007.08.016 |
0.382 |
|
| 2007 |
Aboutabl ME, El-Kadi AO. Constitutive expression and inducibility of CYP1A1 in the H9c2 rat cardiomyoblast cells. Toxicology in Vitro : An International Journal Published in Association With Bibra. 21: 1686-91. PMID 17719738 DOI: 10.1016/J.Tiv.2007.07.002 |
0.779 |
|
| 2007 |
Zordoky BN, El-Kadi AO. H9c2 cell line is a valuable in vitro model to study the drug metabolizing enzymes in the heart. Journal of Pharmacological and Toxicological Methods. 56: 317-22. PMID 17662623 DOI: 10.1016/j.vascn.2007.06.001 |
0.673 |
|
| 2007 |
Elbekai RH, El-Kadi AO. Transcriptional activation and posttranscriptional modification of Cyp1a1 by arsenite, cadmium, and chromium. Toxicology Letters. 172: 106-19. PMID 17606337 DOI: 10.1016/j.toxlet.2007.05.009 |
0.342 |
|
| 2007 |
Anwar-Mohamed A, El-Kadi AO. Induction of cytochrome P450 1a1 by the food flavoring agent, maltol. Toxicology in Vitro : An International Journal Published in Association With Bibra. 21: 685-90. PMID 17317091 DOI: 10.1016/j.tiv.2007.01.003 |
0.391 |
|
| 2007 |
Korashy HM, Shayeganpour A, Brocks DR, El-Kadi AO. Induction of cytochrome P450 1A1 by ketoconazole and itraconazole but not fluconazole in murine and human hepatoma cell lines. Toxicological Sciences : An Official Journal of the Society of Toxicology. 97: 32-43. PMID 17283379 DOI: 10.1093/toxsci/kfm012 |
0.4 |
|
| 2007 |
Elbekai RH, Duke J, El-Kadi AO. Ascorbic acid differentially modulates the induction of heme oxygenase-1, NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase Ya by As(3+), Cd(2+) and Cr(6+). Cancer Letters. 246: 54-62. PMID 16517059 DOI: 10.1016/j.canlet.2006.01.029 |
0.383 |
|
| 2006 |
Korashy HM, El-Kadi AO. The role of aryl hydrocarbon receptor in the pathogenesis of cardiovascular diseases. Drug Metabolism Reviews. 38: 411-50. PMID 16877260 DOI: 10.1080/03602530600632063 |
0.38 |
|
| 2006 |
Elbekai RH, El-Kadi AO. Cytochrome P450 enzymes: central players in cardiovascular health and disease. Pharmacology & Therapeutics. 112: 564-87. PMID 16824612 DOI: 10.1016/j.pharmthera.2005.05.011 |
0.304 |
|
| 2006 |
Korashy HM, El-Kadi AO. Transcriptional regulation of the NAD(P)H:quinone oxidoreductase 1 and glutathione S-transferase ya genes by mercury, lead, and copper. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 152-65. PMID 16243960 DOI: 10.1124/dmd.105.005397 |
0.372 |
|
| 2006 |
Shayeganpour A, El-Kadi AO, Brocks DR. Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 43-50. PMID 16204463 DOI: 10.1124/dmd.105.006742 |
0.345 |
|
| 2005 |
Elbekai RH, El-Kadi AO. The role of oxidative stress in the modulation of aryl hydrocarbon receptor-regulated genes by As3+, Cd2+, and Cr6+. Free Radical Biology & Medicine. 39: 1499-511. PMID 16274885 DOI: 10.1016/j.freeradbiomed.2005.07.012 |
0.335 |
|
| 2005 |
Korashy HM, El-Kadi AO. Regulatory mechanisms modulating the expression of cytochrome P450 1A1 gene by heavy metals. Toxicological Sciences : An Official Journal of the Society of Toxicology. 88: 39-51. PMID 16093525 DOI: 10.1093/toxsci/kfi282 |
0.335 |
|
| 2005 |
Gharavi N, El-Kadi AO. tert-Butylhydroquinone is a novel aryl hydrocarbon receptor ligand. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 365-72. PMID 15608132 DOI: 10.1124/dmd.104.002253 |
0.427 |
|
| 2004 |
Elbekai RH, Korashy HM, Wills K, Gharavi N, El-Kadi AO. Benzo[a]pyrene, 3-methylcholanthrene and beta-naphthoflavone induce oxidative stress in hepatoma hepa 1c1c7 Cells by an AHR-dependent pathway. Free Radical Research. 38: 1191-200. PMID 15621696 DOI: 10.1080/10715760400017319 |
0.318 |
|
| 2004 |
Elbekai RH, El-Kadi AO. Modulation of aryl hydrocarbon receptor-regulated gene expression by arsenite, cadmium, and chromium. Toxicology. 202: 249-69. PMID 15337587 DOI: 10.1016/j.tox.2004.05.009 |
0.323 |
|
| 2004 |
Korashy HM, El-Kadi AO. Differential effects of mercury, lead and copper on the constitutive and inducible expression of aryl hydrocarbon receptor (AHR)-regulated genes in cultured hepatoma Hepa 1c1c7 cells. Toxicology. 201: 153-72. PMID 15297030 DOI: 10.1016/j.tox.2004.04.011 |
0.351 |
|
| 2001 |
Barakat MM, El-Kadi AO, du Souich P. L-NAME prevents in vivo the inactivation but not the down-regulation of hepatic cytochrome P450 caused by an acute inflammatory reaction. Life Sciences. 69: 1559-71. PMID 11554617 DOI: 10.1016/S0024-3205(01)01241-3 |
0.528 |
|
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