| Year |
Citation |
Score |
| 2024 |
Sun Y, Martinez-Ramos C, Chen E, Osawa Y, Zhang H. A General Method to Screen Nanobodies for Cytochrome P450 Enzymes from a Yeast Surface Display Library. Biomedicines. 12. PMID 39200327 DOI: 10.3390/biomedicines12081863 |
0.301 |
|
| 2022 |
Morishima Y, Lau M, Pratt WB, Osawa Y. Dynamic cycling with a unique Hsp90/Hsp70-dependent chaperone machinery and GAPDH is needed for heme insertion and activation of neuronal NO synthase. The Journal of Biological Chemistry. 102856. PMID 36596358 DOI: 10.1016/j.jbc.2022.102856 |
0.354 |
|
| 2020 |
Mehta RK, Pal S, Kondapi K, Sitto M, Dewar C, Devasia T, Schipper MJ, Thomas DG, Basrur V, Pai MP, Morishima Y, Osawa Y, Pratt WB, Lawrence TS, Nyati MK. Low dose Hsp90 inhibitor selectively radiosensitizes HNSCC and Pancreatic xenografts. Clinical Cancer Research : An Official Journal of the American Association For Cancer Research. PMID 32718999 DOI: 10.1158/1078-0432.Ccr-19-3102 |
0.353 |
|
| 2020 |
Davis AK, McMyn NF, Lau M, Morishima Y, Osawa Y. Hsp70:CHIP ubiquitinates dysfunctional but not native neuronal NO synthase. Molecular Pharmacology. PMID 32591478 DOI: 10.1124/Mol.120.119990 |
0.479 |
|
| 2020 |
Su M, Chakraborty S, Osawa Y, Zhang H. Cryo-EM reveals the architecture of the dimeric cytochrome P450 CYP102A1 enzyme and conformational changes required for redox partner recognition. The Journal of Biological Chemistry. PMID 31901079 DOI: 10.1074/Jbc.Ra119.011305 |
0.34 |
|
| 2019 |
Davis AK, Pratt WB, Lieberman AP, Osawa Y. Targeting Hsp70 facilitated protein quality control for treatment of polyglutamine diseases. Cellular and Molecular Life Sciences : Cmls. PMID 31552448 DOI: 10.1007/S00018-019-03302-2 |
0.375 |
|
| 2019 |
Maitra D, Carter EL, Richardson R, Rittié L, Basrur V, Zhang H, Nesvizhskii AI, Osawa Y, Wolf MW, Ragsdale SW, Lehnert N, Herrmann H, Omary MB. Oxygen and conformation dependent protein oxidation and aggregation by porphyrins in hepatocytes and light-exposed cells. Cellular and Molecular Gastroenterology and Hepatology. PMID 31173894 DOI: 10.1016/J.Jcmgh.2019.05.010 |
0.338 |
|
| 2019 |
Pospiech TH, Morishima Y, Osawa Y, Southworth DR. Cryo-EM Structural Analysis of Neuronal Nitric Oxide Synthase Biophysical Journal. 116: 187a-188a. DOI: 10.1016/J.Bpj.2018.11.1040 |
0.442 |
|
| 2018 |
Morishima Y, Mehta RK, Yoshimura M, Lau M, Southworth DR, Lawrence TS, Pratt WB, Nyati MK, Osawa Y. Chaperone Activity and Dimerization Properties of Hsp90α and Hsp90β in Glucocorticoid Receptor Activation by the Multiprotein Hsp90/Hsp70-Dependent Chaperone Machinery. Molecular Pharmacology. PMID 29941666 DOI: 10.1124/Mol.118.112516 |
0.404 |
|
| 2018 |
Zhang H, Yokom AL, Cheng S, Su M, Hollenberg PF, Southworth DR, Osawa Y. The full-length cytochrome P450 enzyme CYP102A1 dimerizes at its reductase domains and has flexible heme domains for efficient catalysis. The Journal of Biological Chemistry. PMID 29618513 DOI: 10.1074/Jbc.Ra117.000600 |
0.359 |
|
| 2017 |
Capper CP, Liu J, McIntosh LR, Larios JM, Johnson MD, Hollenberg PF, Osawa Y, Auchus RJ, Rae JM. Functional characterization of the G162R and D216H genetic variants of human CYP17A1. The Journal of Steroid Biochemistry and Molecular Biology. PMID 29229304 DOI: 10.1016/J.Jsbmb.2017.12.002 |
0.376 |
|
| 2016 |
Morishima Y, Zhang H, Lau M, Osawa Y. Improved method for assembly of hemeprotein neuronal NO-synthase heterodimers. Analytical Biochemistry. PMID 27487179 DOI: 10.1016/J.Ab.2016.07.031 |
0.365 |
|
| 2015 |
Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Targeting Hsp90/Hsp70-based protein quality control for treatment of adult onset neurodegenerative diseases. Annual Review of Pharmacology and Toxicology. 55: 353-71. PMID 25292434 DOI: 10.1146/Annurev-Pharmtox-010814-124332 |
0.362 |
|
| 2014 |
Pratt WB, Morishima Y, Gestwicki JE, Lieberman AP, Osawa Y. A model in which heat shock protein 90 targets protein-folding clefts: rationale for a new approach to neuroprotective treatment of protein folding diseases. Experimental Biology and Medicine (Maywood, N.J.). 239: 1405-13. PMID 24990484 DOI: 10.1177/1535370214539444 |
0.374 |
|
| 2014 |
Yokom AL, Morishima Y, Lau M, Su M, Glukhova A, Osawa Y, Southworth DR. Architecture of the nitric-oxide synthase holoenzyme reveals large conformational changes and a calmodulin-driven release of the FMN domain. The Journal of Biological Chemistry. 289: 16855-65. PMID 24737326 DOI: 10.1074/Jbc.M114.564005 |
0.402 |
|
| 2013 |
Ingelman-Sundberg M, Zhong XB, Hankinson O, Beedanagari S, Yu AM, Peng L, Osawa Y. Potential role of epigenetic mechanisms in the regulation of drug metabolism and transport. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 41: 1725-31. PMID 23918665 DOI: 10.1124/Dmd.113.053157 |
0.304 |
|
| 2013 |
Ahsan A, Ray D, Ramanand SG, Hegde A, Whitehead C, Rehemtulla A, Morishima Y, Pratt WB, Osawa Y, Lawrence TS, Nyati MK. Destabilization of the epidermal growth factor receptor (EGFR) by a peptide that inhibits EGFR binding to heat shock protein 90 and receptor dimerization. The Journal of Biological Chemistry. 288: 26879-86. PMID 23897823 DOI: 10.1074/Jbc.M113.492280 |
0.316 |
|
| 2013 |
Zhang H, Gay SC, Shah M, Foroozesh M, Liu J, Osawa Y, Zhang Q, Stout CD, Halpert JR, Hollenberg PF. Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: Implications for allosteric modulation of cytochrome P450 catalysis Biochemistry. 52: 355-364. PMID 23276288 DOI: 10.1021/Bi301567Z |
0.373 |
|
| 2013 |
Wang AM, Miyata Y, Klinedinst S, Peng HM, Chua JP, Komiyama T, Li X, Morishima Y, Merry DE, Pratt WB, Osawa Y, Collins CA, Gestwicki JE, Lieberman AP. Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation. Nature Chemical Biology. 9: 112-8. PMID 23222885 DOI: 10.1038/Nchembio.1140 |
0.409 |
|
| 2012 |
Clapp KM, Peng HM, Jenkins GJ, Ford MJ, Morishima Y, Lau M, Osawa Y. Ubiquitination of neuronal nitric-oxide synthase in the calmodulin-binding site triggers proteasomal degradation of the protein. The Journal of Biological Chemistry. 287: 42601-10. PMID 23109339 DOI: 10.1074/Jbc.M112.412494 |
0.834 |
|
| 2012 |
Peng HM, Morishima Y, Pratt WB, Osawa Y. Modulation of heme/substrate binding cleft of neuronal nitric-oxide synthase (nNOS) regulates binding of Hsp90 and Hsp70 proteins and nNOS ubiquitination. The Journal of Biological Chemistry. 287: 1556-65. PMID 22128174 DOI: 10.1074/Jbc.M111.323295 |
0.504 |
|
| 2012 |
Osawa Y, Peng H, Clapp KM, Lau M, Morishima Y. Role of Hsp90- and Hsp70-chaperones in regulation of neuronal NO-synthase ubiquitination and proteasomal degradation Nitric Oxide. 27: S5-S6. DOI: 10.1016/J.Niox.2012.04.021 |
0.834 |
|
| 2011 |
Morishima Y, Lau M, Peng HM, Miyata Y, Gestwicki JE, Pratt WB, Osawa Y. Heme-dependent activation of neuronal nitric oxide synthase by cytosol is due to an Hsp70-dependent, thioredoxin-mediated thiol-disulfide interchange in the heme/substrate binding cleft. Biochemistry. 50: 7146-56. PMID 21755988 DOI: 10.1021/Bi200751T |
0.501 |
|
| 2010 |
Clapp KM, Peng HM, Morishima Y, Lau M, Walker VJ, Pratt WB, Osawa Y. C331A mutant of neuronal nitric-oxide synthase is labilized for Hsp70/CHIP (C terminus of HSC70-interacting protein)-dependent ubiquitination. The Journal of Biological Chemistry. 285: 33642-51. PMID 20729196 DOI: 10.1074/Jbc.M110.159178 |
0.839 |
|
| 2010 |
Pratt WB, Morishima Y, Peng HM, Osawa Y. Proposal for a role of the Hsp90/Hsp70-based chaperone machinery in making triage decisions when proteins undergo oxidative and toxic damage. Experimental Biology and Medicine (Maywood, N.J.). 235: 278-89. PMID 20404045 DOI: 10.1258/Ebm.2009.009250 |
0.468 |
|
| 2010 |
Wang AM, Morishima Y, Clapp KM, Peng HM, Pratt WB, Gestwicki JE, Osawa Y, Lieberman AP. Inhibition of hsp70 by methylene blue affects signaling protein function and ubiquitination and modulates polyglutamine protein degradation. The Journal of Biological Chemistry. 285: 15714-23. PMID 20348093 DOI: 10.1074/Jbc.M109.098806 |
0.82 |
|
| 2009 |
Peng HM, Morishima Y, Clapp KM, Lau M, Pratt WB, Osawa Y. Dynamic cycling with Hsp90 stabilizes neuronal nitric oxide synthase through calmodulin-dependent inhibition of ubiquitination. Biochemistry. 48: 8483-90. PMID 19642705 DOI: 10.1021/Bi901058G |
0.833 |
|
| 2008 |
Morishima Y, Wang AM, Yu Z, Pratt WB, Osawa Y, Lieberman AP. CHIP deletion reveals functional redundancy of E3 ligases in promoting degradation of both signaling proteins and expanded glutamine proteins. Human Molecular Genetics. 17: 3942-52. PMID 18784277 DOI: 10.1093/Hmg/Ddn296 |
0.444 |
|
| 2008 |
Pratt WB, Morishima Y, Osawa Y. The Hsp90 chaperone machinery regulates signaling by modulating ligand binding clefts. The Journal of Biological Chemistry. 283: 22885-9. PMID 18515355 DOI: 10.1074/Jbc.R800023200 |
0.408 |
|
| 2007 |
Osawa Y, Lau M, Lowe ER. Plant-Derived Small Molecule Inhibitors of Neuronal NO-Synthase: Potential Effects on Protein Degradation. Plant Signaling & Behavior. 2: 129-30. PMID 19704759 DOI: 10.4161/Psb.2.2.4071 |
0.743 |
|
| 2007 |
Lowe ER, Everett AC, Lau M, Dunbar AY, Michener D, Osawa Y. Naturally occurring neuronal NO-synthase inactivators found in Nicotiana tabacum (Solanaceae) and other plants. Phytomedicine : International Journal of Phytotherapy and Phytopharmacology. 14: 344-52. PMID 17084601 DOI: 10.1016/J.Phymed.2006.09.004 |
0.777 |
|
| 2006 |
Dunbar AY, Jenkins GJ, Jianmongkol S, Nakatsuka M, Lowe ER, Lau M, Osawa Y. Tetrahydrobiopterin protects against guanabenz-mediated inhibition of neuronal nitric-oxide synthase in vitro and in vivo. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 34: 1448-56. PMID 16738031 DOI: 10.1124/Dmd.106.009951 |
0.83 |
|
| 2005 |
Lee AJ, Noon KR, Jianmongkol S, Lau M, Jenkins GJ, Osawa Y. Metabolism of aminoguanidine, diaminoguanidine, and NG-amino-L-arginine by neuronal NO-synthase and covalent alteration of the heme prosthetic group. Chemical Research in Toxicology. 18: 1927-33. PMID 16359183 DOI: 10.1021/Tx050263C |
0.423 |
|
| 2005 |
Morishima Y, Peng HM, Lin HL, Hollenberg PF, Sunahara RK, Osawa Y, Pratt WB. Regulation of cytochrome P450 2E1 by heat shock protein 90-dependent stabilization and CHIP-dependent proteasomal degradation. Biochemistry. 44: 16333-40. PMID 16331994 DOI: 10.1021/Bi0515570 |
0.45 |
|
| 2005 |
Kamada Y, Jenkins GJ, Lau M, Dunbar AY, Lowe ER, Osawa Y. Tetrahydrobiopterin depletion and ubiquitylation of neuronal nitric oxide synthase. Brain Research. Molecular Brain Research. 142: 19-27. PMID 16216381 DOI: 10.1016/J.Molbrainres.2005.09.003 |
0.835 |
|
| 2005 |
Draganov DI, Teiber JF, Speelman A, Osawa Y, Sunahara R, La Du BN. Human paraoxonases (PON1, PON2, and PON3) are lactonases with overlapping and distinct substrate specificities. Journal of Lipid Research. 46: 1239-47. PMID 15772423 DOI: 10.1194/Jlr.M400511-Jlr200 |
0.426 |
|
| 2005 |
Lowe ER, Everett AC, Lee AJ, Lau M, Dunbar AY, Berka V, Tsai AL, Osawa Y. Time-dependent inhibition and tetrahydrobiopterin depletion of endothelial nitric-oxide synthase caused by cigarettes. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 33: 131-8. PMID 15470159 DOI: 10.1124/Dmd.104.001891 |
0.829 |
|
| 2004 |
Peng HM, Morishima Y, Jenkins GJ, Dunbar AY, Lau M, Patterson C, Pratt WB, Osawa Y. Ubiquitylation of neuronal nitric-oxide synthase by CHIP, a chaperone-dependent E3 ligase. The Journal of Biological Chemistry. 279: 52970-7. PMID 15466472 DOI: 10.1074/Jbc.M406926200 |
0.843 |
|
| 2004 |
Dunbar AY, Kamada Y, Jenkins GJ, Lowe ER, Billecke SS, Osawa Y. Ubiquitination and degradation of neuronal nitric-oxide synthase in vitro: dimer stabilization protects the enzyme from proteolysis. Molecular Pharmacology. 66: 964-9. PMID 15235101 DOI: 10.1124/Mol.104.000125 |
0.82 |
|
| 2004 |
Billecke SS, Draganov DI, Morishima Y, Murphy PJ, Dunbar AY, Pratt WB, Osawa Y. The role of hsp90 in heme-dependent activation of apo-neuronal nitric-oxide synthase. The Journal of Biological Chemistry. 279: 30252-8. PMID 15155759 DOI: 10.1074/Jbc.M403864200 |
0.829 |
|
| 2003 |
Morishima Y, Kanelakis KC, Murphy PJ, Lowe ER, Jenkins GJ, Osawa Y, Sunahara RK, Pratt WB. The hsp90 cochaperone p23 is the limiting component of the multiprotein hsp90/hsp70-based chaperone system in vivo where it acts to stabilize the client protein: hsp90 complex. The Journal of Biological Chemistry. 278: 48754-63. PMID 14507910 DOI: 10.1074/Jbc.M309814200 |
0.752 |
|
| 2003 |
Demady DR, Lowe ER, Everett AC, Billecke SS, Kamada Y, Dunbar AY, Osawa Y. Metabolism-based inactivation of neuronal nitric-oxide synthase by components of cigarette and cigarette smoke. Drug Metabolism and Disposition: the Biological Fate of Chemicals. 31: 932-7. PMID 12814971 DOI: 10.1124/Dmd.31.7.932 |
0.764 |
|
| 2003 |
Osawa Y, Lowe ER, Everett AC, Dunbar AY, Billecke SS. Proteolytic degradation of nitric oxide synthase: effect of inhibitors and role of hsp90-based chaperones. The Journal of Pharmacology and Experimental Therapeutics. 304: 493-7. PMID 12538799 DOI: 10.1124/Jpet.102.035055 |
0.818 |
|
| 2002 |
Bender AT, Kamada Y, Kleaveland PA, Osawa Y. Assembly and activation of heme-deficient neuronal NO synthase with various porphyrins. Journal of Inorganic Biochemistry. 91: 625-34. PMID 12237228 DOI: 10.1016/S0162-0134(02)00430-0 |
0.351 |
|
| 2002 |
Vuletich JL, Lowe ER, Jianmongkol S, Kamada Y, Kent UM, Bender AT, Demady DR, Hollenberg PF, Osawa Y. Alteration of the heme prosthetic group of neuronal nitric-oxide synthase during inactivation by N(G)-amino-L-arginine in vitro and in vivo. Molecular Pharmacology. 62: 110-8. PMID 12065761 DOI: 10.1124/Mol.62.1.110 |
0.8 |
|
| 2002 |
Billecke SS, Bender AT, Kanelakis KC, Murphy PJ, Lowe ER, Kamada Y, Pratt WB, Osawa Y. hsp90 is required for heme binding and activation of apo-neuronal nitric-oxide synthase: geldanamycin-mediated oxidant generation is unrelated to any action of hsp90. The Journal of Biological Chemistry. 277: 20504-9. PMID 11923316 DOI: 10.1074/Jbc.M201940200 |
0.846 |
|
| 2001 |
Wu G, Vuletich JL, Kulmacz RJ, Osawa Y, Tsai AL. Peroxidase self-inactivation in prostaglandin H synthase-1 pretreated with cyclooxygenase inhibitors or substituted with mangano protoporphyrin IX. The Journal of Biological Chemistry. 276: 19879-88. PMID 11279106 DOI: 10.1074/jbc.M100628200 |
0.803 |
|
| 2001 |
Demady DR, Jianmongkol S, Vuletich JL, Bender AT, Osawa Y. Agmatine enhances the NADPH oxidase activity of neuronal NO synthase and leads to oxidative inactivation of the enzyme. Molecular Pharmacology. 59: 24-9. PMID 11125020 DOI: 10.1124/Mol.59.1.24 |
0.827 |
|
| 2000 |
Bender AT, Nakatsuka M, Osawa Y. Heme insertion, assembly, and activation of apo-neuronal nitric-oxide synthase in vitro. The Journal of Biological Chemistry. 275: 26018-23. PMID 10950965 DOI: 10.1074/Jbc.275.34.26018 |
0.53 |
|
| 2000 |
Jianmongkol S, Vuletich JL, Bender AT, Demady DR, Osawa Y. Aminoguanidine-mediated inactivation and alteration of neuronal nitric-oxide synthase. The Journal of Biological Chemistry. 275: 13370-6. PMID 10788446 DOI: 10.1074/Jbc.275.18.13370 |
0.817 |
|
| 2000 |
Bender AT, Demady DR, Osawa Y. Ubiquitination of neuronal nitric-oxide synthase in vitro and in vivo. The Journal of Biological Chemistry. 275: 17407-11. PMID 10751385 DOI: 10.1074/Jbc.M000155200 |
0.839 |
|
| 2000 |
Vuletich JL, Osawa Y, Aviram M. Enhanced lipid oxidation by oxidatively modified myoglobin: role of protein-bound heme. Biochemical and Biophysical Research Communications. 269: 647-51. PMID 10720470 DOI: 10.1006/Bbrc.2000.2349 |
0.801 |
|
| 2000 |
Noguchi S, Jianmongkol S, Bender AT, Kamada Y, Demady DR, Osawa Y. Guanabenz-mediated inactivation and enhanced proteolytic degradation of neuronal nitric-oxide synthase. The Journal of Biological Chemistry. 275: 2376-80. PMID 10644688 DOI: 10.1074/Jbc.275.4.2376 |
0.823 |
|
| 1999 |
Bender AT, Silverstein AM, Demady DR, Kanelakis KC, Noguchi S, Pratt WB, Osawa Y. Neuronal nitric-oxide synthase is regulated by the Hsp90-based chaperone system in vivo. The Journal of Biological Chemistry. 274: 1472-8. PMID 9880522 DOI: 10.1074/Jbc.274.3.1472 |
0.82 |
|
| 1998 |
Vuletich JL, Osawa Y. Chemiluminescence assay for oxidatively modified myoglobin. Analytical Biochemistry. 265: 375-80. PMID 9882417 DOI: 10.1006/Abio.1998.2926 |
0.813 |
|
| 1998 |
Roberts ES, Lin Hl, Crowley JR, Vuletich JL, Osawa Y, Hollenberg PF. Peroxynitrite-mediated nitration of tyrosine and inactivation of the catalytic activity of cytochrome P450 2B1. Chemical Research in Toxicology. 11: 1067-74. PMID 9760281 DOI: 10.1021/Tx980099B |
0.767 |
|
| 1997 |
Sugiyama K, Highet RJ, Woods A, Cotter RJ, Osawa Y. Hydrogen peroxide-mediated alteration of the heme prosthetic group of metmyoglobin to an iron chlorin product: evidence for a novel oxidative pathway. Proceedings of the National Academy of Sciences of the United States of America. 94: 796-801. PMID 9023336 DOI: 10.1073/Pnas.94.3.796 |
0.357 |
|
| 1996 |
Osawa Y, Williams MS. Covalent crosslinking of the heme prosthetic group to myoglobin by H2O2: Toxicological implications Free Radical Biology and Medicine. 21: 35-41. PMID 8791091 DOI: 10.1016/0891-5849(95)02215-5 |
0.453 |
|
| 1995 |
Osawa Y, Davila JC, Nakatsuka M, Meyer CA, Darbyshire JF. Inhibition of p450 cytochromes by reactive intermediates Drug Metabolism Reviews. 27: 61-72. PMID 7641585 DOI: 10.3109/03602539509029815 |
0.332 |
|
| 1994 |
Nakatsuka M, Osawa Y. Selective inhibition of the 12-lipoxygenase pathway of arachidonic acid metabolism by L-arginine or sodium nitroprusside in intact human platelets. Biochemical and Biophysical Research Communications. 200: 1630-4. PMID 8185619 DOI: 10.1006/Bbrc.1994.1638 |
0.372 |
|
| 1994 |
Sugiyama K, Correia MA, Thummel KE, Nagata K, Darbyshire JF, Osawa Y, Gillette JR. pH-dependent one- and two-electron oxidation of 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine catalyzed by horseradish peroxidase. Chemical Research in Toxicology. 7: 633-42. PMID 7841342 DOI: 10.1021/Tx00041A008 |
0.441 |
|
| 1994 |
Sugiyama K, Woods A, Cotter RJ, Highet RJ, Darbyshire JF, Osawa Y, Gillette JR. Inactivation of horseradish peroxidase by 3,5-dicarbethoxy-2,6-dimethyl-4-ethyl-1,4-dihydropyridine. Chemical Research in Toxicology. 7: 843-9. PMID 7696541 DOI: 10.1021/Tx00042A019 |
0.418 |
|
| 1993 |
Korzekwa KR, Trager WF, Mancewicz J, Osawa Y. Studies on the mechanism of aromatase and other cytochrome P450 mediated deformylation reactions. The Journal of Steroid Biochemistry and Molecular Biology. 44: 367-73. PMID 8476750 DOI: 10.1016/0960-0760(93)90240-W |
0.328 |
|
| 1993 |
Wink DA, Osawa Y, Darbyshire JF, Jones CR, Eshenaur SC, Nims RW. Inhibition of cytochromes P450 by nitric oxide and a nitric oxide-releasing agent. Archives of Biochemistry and Biophysics. 300: 115-23. PMID 8424643 DOI: 10.1006/Abbi.1993.1016 |
0.407 |
|
| 1993 |
Osawa Y, Darbyshire JF, Meyer CA, Alayash AI. Differential susceptibilities of the prosthetic heme of hemoglobin-based red cell substitutes. Implications in the design of safer agents Biochemical Pharmacology. 46: 2299-2305. PMID 8274164 DOI: 10.1016/0006-2952(93)90621-3 |
0.404 |
|
| 1993 |
Osawa Y, Davila JC. Phencyclidine, a psychotomimetic agent and drug of abuse, is a suicide inhibitor of brain nitric oxide synthase. Biochemical and Biophysical Research Communications. 194: 1435-1439. PMID 7688965 DOI: 10.1006/Bbrc.1993.1985 |
0.499 |
|
| 1992 |
Kutty G, Hayden B, Osawa Y, Wiggert B, Chader GJ, Kutty RK. Heme oxygenase: expression in human retina and modulation by stress agents in a human retinoblastoma cell model system. Current Eye Research. 11: 153-60. PMID 1572205 DOI: 10.3109/02713689209000066 |
0.402 |
|
| 1992 |
Osawa Y, Highet RJ, Pohl LR. The use of stable isotopes to identify reactive metabolites and target macromolecules associated with toxicities of halogenated hydrocarbon compounds Xenobiotica. 22: 1147-1156. PMID 1441605 DOI: 10.3109/00498259209051868 |
0.357 |
|
| 1991 |
Osawa Y, Korzekwa K. Oxidative modification by low levels of HOOH can transform myoglobin to an oxidase. Proceedings of the National Academy of Sciences of the United States of America. 88: 7081-7085. PMID 1871123 DOI: 10.1073/Pnas.88.16.7081 |
0.464 |
|
| 1991 |
Korzekwa KR, Trager WF, Smith SJ, Osawa Y, Gillette JR. Theoretical studies on the mechanism of conversion of androgens to estrogens by aromatase. Biochemistry. 30: 6155-62. PMID 1647815 DOI: 10.1021/Bi00239A011 |
0.315 |
|
| 1989 |
Osawa Y, Pohl LR. Covalent bonding of the prosthetic heme to protein: a potential mechanism for the suicide inactivation or activation of hemoproteins. Chemical Research in Toxicology. 2: 131-141. PMID 2519716 DOI: 10.1021/Tx00009A001 |
0.405 |
|
| 1987 |
Osawa Y, Coon MJ. Radiometric assay for cytochrome P-450-catalyzed progesterone 16 alpha-hydroxylation and determination of an apparent isotope effect. Analytical Biochemistry. 164: 355-61. PMID 3674383 DOI: 10.1016/0003-2697(87)90504-5 |
0.328 |
|
| 1987 |
Osawa Y, Osawa Y, Coon MJ. Stereochemistry of the functional group determines the mechanism of aromatase inhibition by 6-bromoandrostenedione. Endocrinology. 121: 1010-6. PMID 3622372 DOI: 10.1210/Endo-121-3-1010 |
0.385 |
|
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