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Alessio Accardi, Ph.D. - Publications

Affiliations: 
Anesthesiology Weill Cornell Medical College, New York, NY, United States 
Area:
Chloride channels
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71 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftci HD, Falzone ME, Huysmans G, Robertson JL, Boudker O, Accardi A. Author Correction: Structural basis of pH-dependent activation in a CLC transporter. Nature Structural & Molecular Biology. PMID 38355726 DOI: 10.1038/s41594-024-01242-5  0.567
2024 Fortea E, Lee S, Chadda R, Argyros Y, Sandal P, Mahoney-Kruszka R, Ciftici D, Falzone ME, Huysmans G, Robertson JL, Boudker O, Accardi A. Structural basis of pH-dependent activation in a CLC transporter. Nature Structural & Molecular Biology. PMID 38279055 DOI: 10.1038/s41594-023-01210-5  0.634
2022 Leisle L, Lam K, Dehghani-Ghahnaviyeh S, Fortea E, Galpin JD, Ahern CA, Tajkhorshid E, Accardi A. Backbone amides are determinants of Cl selectivity in CLC ion channels. Nature Communications. 13: 7508. PMID 36473856 DOI: 10.1038/s41467-022-35279-1  0.321
2021 Fortea E, Accardi A. A quantitative flux assay for the study of reconstituted Cl channels and transporters. Methods in Enzymology. 652: 243-272. PMID 34059284 DOI: 10.1016/bs.mie.2021.01.026  0.477
2020 Leisle L, Xu Y, Fortea E, Lee S, Galpin JD, Vien M, Ahern CA, Accardi A, Bernèche S. Divergent Cland H pathways underlie transport coupling and gating in CLC exchangers and channels. Elife. 9. PMID 32343228 DOI: 10.7554/Elife.51224  0.56
2020 Falzone ME, Accardi A. Reconstitution of Proteoliposomes for Phospholipid Scrambling and Nonselective Channel Assays. Methods in Molecular Biology (Clifton, N.J.). 2127: 207-225. PMID 32112325 DOI: 10.1007/978-1-0716-0373-4_15  0.437
2020 Zajac M, Chakraborty K, Saha S, Mahadevan V, Infield DT, Accardi A, Qiu Z, Krishnan Y. What biologists want from their chloride reporters - a conversation between chemists and biologists. Journal of Cell Science. 133. PMID 31974277 DOI: 10.1242/Jcs.240390  0.416
2020 Leisle L, Xu Y, Fortea E, Lee S, Galpin JD, Vien M, Ahern CA, Accardi A, Bernèche S. Author response: Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels Elife. DOI: 10.7554/Elife.51224.Sa2  0.523
2020 Accardi A, Falzone M, Lee B, Cheng X, Khelashvili G, Weinstein H. Structural Basis of Lipid Scrambling and Ion Conduction by TMEM16 Scramblases The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00173  0.352
2020 Accardi A. Structural Basis of Lipid and Ion Transport by TMEM16 Scramblases Biophysical Journal. 118: 4a. DOI: 10.1016/J.Bpj.2019.11.213  0.485
2019 Khelashvili G, Cheng X, Falzone ME, Doktorova M, Accardi A, Weinstein H. Membrane lipids are both the substrates and a mechanistically responsive environment of TMEM16 scramblase proteins. Journal of Computational Chemistry. PMID 31750558 DOI: 10.1002/Jcc.26105  0.347
2019 Khelashvili G, Falzone ME, Cheng X, Lee BC, Accardi A, Weinstein H. Dynamic modulation of the lipid translocation groove generates a conductive ion channel in Ca-bound nhTMEM16. Nature Communications. 10: 4972. PMID 31672969 DOI: 10.1038/S41467-019-12865-4  0.458
2019 Bushell SR, Pike ACW, Falzone ME, Rorsman NJG, Ta CM, Corey RA, Newport TD, Christianson JC, Scofano LF, Shintre CA, Tessitore A, Chu A, Wang Q, Shrestha L, Mukhopadhyay SMM, ... ... Accardi A, et al. The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K. Nature Communications. 10: 3956. PMID 31477691 DOI: 10.1038/S41467-019-11753-1  0.395
2019 Falzone ME, Rheinberger J, Lee BC, Peyear T, Sasset L, Raczkowski AM, Eng ET, Di Lorenzo A, Andersen OS, Nimigean CM, Accardi A. Structural basis of Ca-dependent activation and lipid transport by a TMEM16 scramblase. Elife. 8. PMID 30648972 DOI: 10.7554/Elife.43229  0.677
2019 Falzone M, Rheinberger J, Lee B, Peyear T, Sasset L, Raczkowski A, Eng E, Di Lorenzo A, Anderson O, Nimigean C, Accardi A. Cryo-EM Structures Reveal Bilayer Remodeling during Ca2+ Activation of a TMEM16 Scramblase Biophysical Journal. 116: 26a. DOI: 10.1016/J.Bpj.2018.11.185  0.602
2018 Lee BC, Khelashvili G, Falzone M, Menon AK, Weinstein H, Accardi A. Gating mechanism of the extracellular entry to the lipid pathway in a TMEM16 scramblase. Nature Communications. 9: 3251. PMID 30108217 DOI: 10.1038/S41467-018-05724-1  0.388
2018 Malvezzi M, Andra KK, Pandey K, Lee BC, Falzone ME, Brown A, Iqbal R, Menon AK, Accardi A. Out-of-the-groove transport of lipids by TMEM16 and GPCR scramblases. Proceedings of the National Academy of Sciences of the United States of America. PMID 29925604 DOI: 10.1073/Pnas.1806721115  0.459
2018 Falzone ME, Malvezzi M, Lee BC, Accardi A. Known structures and unknown mechanisms of TMEM16 scramblases and channels. The Journal of General Physiology. PMID 29915161 DOI: 10.1085/Jgp.201711957  0.477
2018 Falzone ME, Rheinberger J, Lee B, Peyear T, Sasset L, Raczkowski AM, Eng ET, Lorenzo AD, Andersen OS, Nimigean CM, Accardi A. Author response: Structural basis of Ca2+-dependent activation and lipid transport by a TMEM16 scramblase Elife. DOI: 10.7554/Elife.43229.058  0.669
2018 Lee B, Kelashvili G, Falzone M, Weinstein H, Accardi A. Identification of the Extracellular Gate of a TMEM16 Scramblase Biophysical Journal. 114: 611a. DOI: 10.1016/J.Bpj.2017.11.3339  0.308
2017 Vien M, Basilio D, Leisle L, Accardi A. Probing the conformation of a conserved glutamic acid within the Cl(-) pathway of a CLC H(+)/Cl(-) exchanger. The Journal of General Physiology. PMID 28246117 DOI: 10.1085/Jgp.201611682  0.784
2017 Khelashvili G, Cheol Lee B, Falzone M, Menon AK, Accardi A, Weinstein H. Role of Hydrophilic Groove of the TMEM16 Protein in Lipid Scrambling Biophysical Journal. 112: 392a. DOI: 10.1016/J.Bpj.2016.11.2131  0.423
2017 Xu Y, Vien M, Liang C, Accardi A, Bernèche S. Molecular Mechanism of Cl − /H + Coupling in a CLC Antiporter Biophysical Journal. 112: 336a. DOI: 10.1016/J.Bpj.2016.11.1819  0.35
2017 Lee B, Falzone M, Menon A, Accardi A. Identification of Residues Important for Ion and Lipid Transport in a TMEM16 Scramblase Biophysical Journal. 112: 228a. DOI: 10.1016/J.Bpj.2016.11.1254  0.54
2016 Lee BC, Menon AK, Accardi A. The nhTMEM16 Scramblase Is Also a Nonselective Ion Channel. Biophysical Journal. 111: 1919-1924. PMID 27806273 DOI: 10.1016/J.Bpj.2016.09.032  0.522
2016 Accardi A. Mechanisms of Ion and Lipid Transport by TMEM16 Scramblases Biophysical Journal. 110: 174a. DOI: 10.1016/J.Bpj.2015.11.968  0.462
2016 Malvezzi M, Iqbal R, Brown A, Menon A, Accardi A. Sizing up the Lipid Pathway in a TMEM16 Phospholipid Scramblase Biophysical Journal. 110: 291a. DOI: 10.1016/J.Bpj.2015.11.1573  0.356
2015 Accardi A. CELL SIGNALING. Lipids link ion channels and cancer. Science (New York, N.Y.). 349: 789-90. PMID 26293939 DOI: 10.1126/Science.Aad0874  0.374
2015 Accardi A. Structure and gating of CLC channels and exchangers. The Journal of Physiology. 593: 4129-38. PMID 26148215 DOI: 10.1113/Jp270575  0.549
2015 Basilio D, Accardi A. A Proteoliposome-Based Efflux Assay to Determine Single-molecule Properties of Cl- Channels and Transporters. Journal of Visualized Experiments : Jove. PMID 25938223 DOI: 10.3791/52369  0.769
2015 Picollo A, Malvezzi M, Accardi A. TMEM16 proteins: unknown structure and confusing functions. Journal of Molecular Biology. 427: 94-105. PMID 25451786 DOI: 10.1016/J.Jmb.2014.09.028  0.492
2014 Accardi A. Unveiling the secret lives of glutamate transporters: VGLUTs engage in multiple transport modes. Neuron. 84: 1110-2. PMID 25521371 DOI: 10.1016/J.Neuron.2014.12.008  0.436
2014 Corral-Rodríguez MÁ, Stuiver M, Abascal-Palacios G, Diercks T, Oyenarte I, Ereño-Orbea J, de Opakua AI, Blanco FJ, Encinar JA, Spiwok V, Terashima H, Accardi A, Müller D, Martínez-Cruz LA. Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure. The Biochemical Journal. 464: 23-34. PMID 25184538 DOI: 10.1042/Bj20140409  0.367
2014 Basilio D, Noack K, Picollo A, Accardi A. Conformational changes required for H(+)/Cl(-) exchange mediated by a CLC transporter. Nature Structural & Molecular Biology. 21: 456-63. PMID 24747941 DOI: 10.1038/Nsmb.2814  0.779
2014 Malvezzi M, Janjusevic R, Menon A, Accardi A. Lipid Modulation of a Dual Function TMEM16 Channel/Scramblase Biophysical Journal. 106: 155a. DOI: 10.1016/J.Bpj.2013.11.890  0.441
2014 Xu Y, Liang C, Basilio D, Accardi A, Bernèche S. Conformational Changes Required for Chloride Ion Permeation in the CLC-ec1 Exchanger Biophysical Journal. 106: 145a-146a. DOI: 10.1016/J.Bpj.2013.11.841  0.761
2014 Basilio D, Vera A, Accardi A. Testing the Limits of Stoichiometric Exchange in a CLC-Type Transporter Biophysical Journal. 106: 145a. DOI: 10.1016/J.Bpj.2013.11.840  0.779
2013 Terashima H, Picollo A, Accardi A. Purified TMEM16A is sufficient to form Ca2+-activated Cl- channels. Proceedings of the National Academy of Sciences of the United States of America. 110: 19354-9. PMID 24167264 DOI: 10.1073/Pnas.1312014110  0.435
2013 Malvezzi M, Chalat M, Janjusevic R, Picollo A, Terashima H, Menon AK, Accardi A. Ca2+-dependent phospholipid scrambling by a reconstituted TMEM16 ion channel. Nature Communications. 4: 2367. PMID 23996062 DOI: 10.1038/Ncomms3367  0.411
2013 Terashima H, Picollo A, Accardi A. Purification and Functional Reconstitution of the TMEM16A Ca2+ Activated Cl− Channel Biophysical Journal. 104: 628a. DOI: 10.1016/J.Bpj.2012.11.3476  0.41
2013 Basilio D, Noack K, Picollo A, Accardi A. Conformational Changes Outside the Ion Pathway are required for Transport in a CLC-Type Cl−/H+ Exchanger Biophysical Journal. 104: 627a. DOI: 10.1016/J.Bpj.2012.11.3468  0.795
2013 Malvezzi M, Chalat M, Terashima H, Janjusevic R, Menon A, Accardi A. Ca2+-Dependent Ion and Lipid Transport Mediated by a Fungal TMEM16 Homologue Biophysical Journal. 104: 366a. DOI: 10.1016/J.Bpj.2012.11.2034  0.487
2012 Picollo A, Xu Y, Johner N, Bernèche S, Accardi A. Synergistic substrate binding determines the stoichiometry of transport of a prokaryotic H(+)/Cl(-) exchanger. Nature Structural & Molecular Biology. 19: 525-31, S1. PMID 22484316 DOI: 10.1038/Nsmb.2277  0.521
2011 Ying SW, Tibbs GR, Picollo A, Abbas SY, Sanford RL, Accardi A, Hofmann F, Ludwig A, Goldstein PA. PIP2-mediated HCN3 channel gating is crucial for rhythmic burst firing in thalamic intergeniculate leaflet neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10412-23. PMID 21753018 DOI: 10.1523/Jneurosci.0021-11.2011  0.355
2011 Picollo A, Accardi A. Synergistic Substrate binding in the CLC-Ec1 Exchanger Biophysical Journal. 100: 246a. DOI: 10.1016/J.Bpj.2010.12.1559  0.514
2011 Malvezzi M, Picollo A, Accardi A. Proton Transport and Conformational Changes in H+/CL- Exchangers Biophysical Journal. 100: 245a. DOI: 10.1016/J.Bpj.2010.12.1555  0.569
2010 Picollo A, Malvezzi M, Accardi A. Proton block of the CLC-5 Cl-/H+ exchanger. The Journal of General Physiology. 135: 653-9. PMID 20513761 DOI: 10.1085/Jgp.201010428  0.509
2010 Accardi A, Picollo A. CLC channels and transporters: proteins with borderline personalities. Biochimica Et Biophysica Acta. 1798: 1457-64. PMID 20188062 DOI: 10.1016/J.Bbamem.2010.02.022  0.551
2010 Picollo A, Malvezzi M, Accardi A. Proton Block of Human CLC-5 Cl-/H+ Exchanger Biophysical Journal. 98: 320a. DOI: 10.1016/J.Bpj.2009.12.1737  0.47
2010 Hills C, Bruce S, Accardi A. Role of the Q-R Linker in H+/Cl- Coupling in a CLC Exchanger Biophysical Journal. 98: 320a. DOI: 10.1016/J.Bpj.2009.12.1736  0.536
2009 Picollo A, Malvezzi M, Houtman JC, Accardi A. Basis of substrate binding and conservation of selectivity in the CLC family of channels and transporters. Nature Structural & Molecular Biology. 16: 1294-301. PMID 19898476 DOI: 10.1038/Nsmb.1704  0.566
2009 Malvezzi M, Picollo A, Accardi A. Cooperative Ion Binding and Transport Mediated by a CLC-Type H+/Cl− Exchanger Biophysical Journal. 96: 471a. DOI: 10.1016/J.Bpj.2008.12.2423  0.45
2009 Picollo A, Accardi A. Molecular Mechanisms of Cl−/H+ Coupling in CLC-ec1 Biophysical Journal. 96: 269a-270a. DOI: 10.1016/J.Bpj.2008.12.1333  0.463
2008 Jayaram H, Accardi A, Wu F, Williams C, Miller C. Ion permeation through a Cl--selective channel designed from a CLC Cl-/H+ exchanger. Proceedings of the National Academy of Sciences of the United States of America. 105: 11194-9. PMID 18678918 DOI: 10.1073/Pnas.0804503105  0.686
2007 Walden M, Accardi A, Wu F, Xu C, Williams C, Miller C. Uncoupling and turnover in a Cl-/H+ exchange transporter. The Journal of General Physiology. 129: 317-29. PMID 17389248 DOI: 10.1085/Jgp.200709756  0.793
2006 Accardi A, Lobet S, Williams C, Miller C, Dutzler R. Synergism between halide binding and proton transport in a CLC-type exchanger. Journal of Molecular Biology. 362: 691-9. PMID 16949616 DOI: 10.1016/J.Jmb.2006.07.081  0.619
2006 Accardi A. Structure and Function of CLC Chloride Channels and Transporters Advances in Molecular and Cell Biology. 38: 59-82. DOI: 10.1016/S1569-2558(06)38003-4  0.401
2005 Accardi A, Walden M, Nguitragool W, Jayaram H, Williams C, Miller C. Separate ion pathways in a Cl-/H+ exchanger. The Journal of General Physiology. 126: 563-70. PMID 16316975 DOI: 10.1085/Jgp.200509417  0.786
2004 Accardi A, Miller C. Secondary active transport mediated by a prokaryotic homologue of ClC Cl- channels. Nature. 427: 803-7. PMID 14985752 DOI: 10.1038/Nature02314  0.624
2004 Accardi A, Kolmakova-Partensky L, Williams C, Miller C. Ionic currents mediated by a prokaryotic homologue of CLC Cl- channels. The Journal of General Physiology. 123: 109-19. PMID 14718478 DOI: 10.1085/Jgp.200308935  0.537
2003 Sokolova O, Accardi A, Gutierrez D, Lau A, Rigney M, Grigorieff N. Conformational changes in the C terminus of Shaker K+ channel bound to the rat Kvbeta2-subunit. Proceedings of the National Academy of Sciences of the United States of America. 100: 12607-12. PMID 14569011 DOI: 10.1073/Pnas.2235650100  0.322
2003 Accardi A, Pusch M. Conformational changes in the pore of CLC-0. The Journal of General Physiology. 122: 277-93. PMID 12913090 DOI: 10.1085/Jgp.200308834  0.416
2003 Estévez R, Schroeder BC, Accardi A, Jentsch TJ, Pusch M. Conservation of chloride channel structure revealed by an inhibitor binding site in ClC-1. Neuron. 38: 47-59. PMID 12691663 DOI: 10.1016/S0896-6273(03)00168-5  0.402
2002 Pusch M, Accardi A, Liantonio A, Guida P, Traverso S, Camerino DC, Conti F. Mechanisms of block of muscle type CLC chloride channels (Review). Molecular Membrane Biology. 19: 285-92. PMID 12512775 DOI: 10.1080/09687680210166938  0.398
2002 Iyer R, Iverson TM, Accardi A, Miller C. A biological role for prokaryotic ClC chloride channels. Nature. 419: 715-8. PMID 12384697 DOI: 10.1038/Nature01000  0.501
2002 Liantonio A, Accardi A, Carbonara G, Fracchiolla G, Loiodice F, Tortorella P, Traverso S, Guida P, Pierno S, De Luca A, Camerino DC, Pusch M. Molecular requisites for drug binding to muscle CLC-1 and renal CLC-K channel revealed by the use of phenoxy-alkyl derivatives of 2-(p-chlorophenoxy)propionic acid. Molecular Pharmacology. 62: 265-71. PMID 12130677 DOI: 10.1124/Mol.62.2.265  0.343
2001 Accardi A, Ferrera L, Pusch M. Drastic reduction of the slow gate of human muscle chloride channel (ClC-1) by mutation C277S. The Journal of Physiology. 534: 745-52. PMID 11483705 DOI: 10.1111/J.1469-7793.2001.00745.X  0.347
2001 Pusch M, Accardi A, Liantonio A, Ferrera L, De Luca A, Camerino DC, Conti F. Mechanism of block of single protopores of the Torpedo chloride channel ClC-0 by 2-(p-chlorophenoxy)butyric acid (CPB). The Journal of General Physiology. 118: 45-62. PMID 11432801 DOI: 10.1085/Jgp.118.1.45  0.383
2000 Accardi A, Pusch M. Fast and slow gating relaxations in the muscle chloride channel CLC-1. The Journal of General Physiology. 116: 433-44. PMID 10962018 DOI: 10.1085/Jgp.116.3.433  0.329
2000 Pusch M, Liantonio A, Bertorello L, Accardi A, De Luca A, Pierno S, Tortorella V, Camerino DC. Pharmacological characterization of chloride channels belonging to the ClC family by the use of chiral clofibric acid derivatives. Molecular Pharmacology. 58: 498-507. PMID 10953042 DOI: 10.1124/Mol.58.3.498  0.384
1999 Carpaneto A, Accardi A, Pisciotta M, Gambale F. Chloride channels activated by hypotonicity in N2A neuroblastoma cell line. Experimental Brain Research. 124: 193-9. PMID 9928842 DOI: 10.1007/S002210050614  0.424
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