Bernhard Luscher, PhD - Publications

Affiliations: 
1999- Biology, Biochemistry and Molecular Biology Pennsylvania State University, State College, PA, United States 
Area:
GABA, GABA(A) receptors, neuropsychiatric disorders, antidepressant drug mechanisms, palmitoylation

64 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Belelli D, Hales TG, Lambert JJ, Luscher B, Olsen R, Peters JA, Rudolph U, Sieghart W. GABA receptors in GtoPdb v.2021.3. Iuphar/Bps Guide to Pharmacology Cite. 2021. PMID 35005623 DOI: 10.2218/gtopdb/F72/2021.3  0.37
2021 Malyshev AV, Sukhanova IA, Zlobin AS, Gedzun VR, Pavshintsev VV, Vasileva EV, Zalevsky AO, Doronin II, Mitkin NA, Golovin AV, Lovat ML, Kovalev GI, Zolotarev YA, Kuchumov AR, Babkin GA, ... Luscher B, et al. Screening and Behavioral Validation of a Novel Peptide, LCGA-17, With Anxiolytic-Like Properties. Frontiers in Neuroscience. 15: 705590. PMID 34421525 DOI: 10.3389/fnins.2021.705590  0.344
2021 Lüscher B, Ahel I, Altmeyer M, Ashworth A, Bai P, Chang P, Cohen M, Corda D, Dantzer F, Daugherty MD, Dawson TM, Dawson VL, Deindl S, Fehr AR, Feijs KLH, et al. ADP-ribosyltransferases, an update on function and nomenclature. The Febs Journal. PMID 34323016 DOI: 10.1111/febs.16142  0.549
2020 Jefferson SJ, Feng M, Chon U, Guo Y, Kim Y, Luscher B. Disinhibition of somatostatin interneurons confers resilience to stress in male but not female mice. Neurobiology of Stress. 13: 100238. PMID 33344694 DOI: 10.1016/J.Ynstr.2020.100238  0.374
2020 Luscher B, Feng M, Jefferson SJ. Antidepressant mechanisms of ketamine: Focus on GABAergic inhibition. Advances in Pharmacology (San Diego, Calif.). 89: 43-78. PMID 32616214 DOI: 10.1016/Bs.Apha.2020.03.002  0.395
2019 Lüscher B, Möhler H. Brexanolone, a neurosteroid antidepressant, vindicates the GABAergic deficit hypothesis of depression and may foster resilience. F1000research. 8. PMID 31275559 DOI: 10.12688/F1000Research.18758.1  0.675
2019 Feng M, Crowley NA, Patel A, Guo Y, Bugni SE, Luscher B. Reversal of a Treatment-Resistant, Depression-Related Brain State with the Kv7 Channel Opener Retigabine. Neuroscience. PMID 30858110 DOI: 10.1016/J.Neuroscience.2019.03.003  0.321
2019 Crowley NA, Magee SN, Feng M, Jefferson SN, Morris CJ, Dao NC, Brockway DF, Luscher B. Ketamine normalizes binge drinking-induced defects in glutamatergic synaptic transmission and ethanol drinking behavior in female but not male mice. Neuropharmacology. PMID 30731135 DOI: 10.1016/J.Neuropharm.2019.02.003  0.342
2019 Belelli D, Hales TG, Lambert JJ, Luscher B, Olsen R, Peters JA, Rudolph U, Sieghart W. GABAA receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f72/2019.4  0.318
2017 Wang S, Mott KR, Cilluffo M, Kilpatrick CL, Murakami S, Ljubimov AV, Kousoulas KG, Awasthi S, Luscher B, Ghiasi H. The absence of DHHC3 affects primary and latent HSV-1 infection. Journal of Virology. PMID 29187538 DOI: 10.1128/Jvi.01599-17  0.682
2017 Wang S, Mott KR, Wawrowsky K, Kousoulas KG, Luscher B, Ghiasi H. Binding of HSV-1 UL20 to GODZ affects its palmitoylation and is essential for infectivity and proper targeting and localization of UL20 and gK. Journal of Virology. PMID 28724772 DOI: 10.1128/Jvi.00945-17  0.332
2017 Fuchs T, Jefferson SJ, Hooper A, Yee PP, Maguire J, Luscher B. Disinhibition of somatostatin-positive interneurons by deletion of postsynaptic GABAA receptors. Molecular Psychiatry. 22: 787. PMID 28529315 DOI: 10.1038/Mp.2017.110  0.467
2017 Du K, Murakami S, Sun Y, Kilpatrick C, Luscher B. DHHC7 Palmitoylates Glut4 and Regulates Glut4 Membrane Translocation. The Journal of Biological Chemistry. PMID 28057756 DOI: 10.1074/Jbc.M116.747139  0.67
2016 Kilpatrick CL, Murakami S, Feng M, Wu X, Lal R, Chen G, Du K, Luscher B. Dissociation of Golgi-Associated DHHC-Type Zinc Finger Protein (GODZ) and Sertoli Cell Gene with a Zinc Finger Domain-β (SERZ-β)-Mediated Palmitoylation by Loss of Function Analyses in Knockout Mice. The Journal of Biological Chemistry. PMID 27875292 DOI: 10.1074/Jbc.M116.732768  0.732
2016 Leppä E, Linden AM, Aller MI, Wulff P, Vekovischeva O, Luscher B, Lüddens H, Wisden W, Korpi ER. Increased Motor-Impairing Effects of the Neuroactive Steroid Pregnanolone in Mice with Targeted Inactivation of the GABAA Receptor γ2 Subunit in the Cerebellum. Frontiers in Pharmacology. 7: 403. PMID 27833556 DOI: 10.3389/Fphar.2016.00403  0.476
2016 Fuchs T, Jefferson SJ, Hooper A, Yee PH, Maguire J, Luscher B. Disinhibition of somatostatin-positive GABAergic interneurons results in an anxiolytic and antidepressant-like brain state. Molecular Psychiatry. PMID 27821870 DOI: 10.1038/Mp.2016.188  0.456
2016 Ren Z, Pribiag H, Jefferson SJ, Shorey M, Fuchs T, Stellwagen D, Luscher B. Bidirectional Homeostatic Regulation of a Depression-Related Brain State by Gamma-Aminobutyric Acidergic Deficits and Ketamine Treatment. Biological Psychiatry. PMID 27062563 DOI: 10.1016/J.Biopsych.2016.02.009  0.664
2015 Ebersole B, Petko J, Woll M, Murakami S, Sokolina K, Wong V, Stagljar I, Lüscher B, Levenson R. Effect of C-Terminal S-Palmitoylation on D2 Dopamine Receptor Trafficking and Stability. Plos One. 10: e0140661. PMID 26535572 DOI: 10.1371/Journal.Pone.0140661  0.712
2015 Luscher B, Fuchs T. GABAergic control of depression-related brain states. Advances in Pharmacology (San Diego, Calif.). 73: 97-144. PMID 25637439 DOI: 10.1016/Bs.Apha.2014.11.003  0.438
2015 Ren Z, Sahir N, Murakami S, Luellen BA, Earnheart JC, Lal R, Kim JY, Song H, Luscher B. Defects in dendrite and spine maturation and synaptogenesis associated with an anxious-depressive-like phenotype of GABAA receptor-deficient mice. Neuropharmacology. 88: 171-9. PMID 25107590 DOI: 10.1016/J.Neuropharm.2014.07.019  0.765
2014 Dejanovic B, Semtner M, Ebert S, Lamkemeyer T, Neuser F, Lüscher B, Meier JC, Schwarz G. Palmitoylation of gephyrin controls receptor clustering and plasticity of GABAergic synapses. Plos Biology. 12: e1001908. PMID 25025157 DOI: 10.1371/Journal.Pbio.1001908  0.417
2013 Luscher B, Fuchs T. Adult hippocampal neurogenesis in the absence of serotonin (Commentary on Diaz et al.). The European Journal of Neuroscience. 38: 2649. PMID 23992131 DOI: 10.1111/Ejn.12335  0.345
2013 Forst AH, Karlberg T, Herzog N, Thorsell AG, Gross A, Feijs KL, Verheugd P, Kursula P, Nijmeijer B, Kremmer E, Kleine H, Ladurner AG, Schüler H, Lüscher B. Recognition of mono-ADP-ribosylated ARTD10 substrates by ARTD8 macrodomains. Structure (London, England : 1993). 21: 462-75. PMID 23473667 DOI: 10.1016/J.Str.2012.12.019  0.531
2013 Reid CA, Kim T, Phillips AM, Low J, Berkovic SF, Luscher B, Petrou S. Multiple molecular mechanisms for a single GABAA mutation in epilepsy. Neurology. 80: 1003-8. PMID 23408872 DOI: 10.1212/Wnl.0B013E3182872867  0.303
2012 Shen Q, Fuchs T, Sahir N, Luscher B. GABAergic control of critical developmental periods for anxiety- and depression-related behavior in mice. Plos One. 7: e47441. PMID 23071808 DOI: 10.1371/Journal.Pone.0047441  0.574
2012 Song J, Zhong C, Bonaguidi MA, Sun GJ, Hsu D, Gu Y, Meletis K, Huang ZJ, Ge S, Enikolopov G, Deisseroth K, Luscher B, Christian KM, Ming GL, Song H. Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision. Nature. 489: 150-4. PMID 22842902 DOI: 10.1038/Nature11306  0.381
2012 Wu X, Wu Z, Ning G, Guo Y, Ali R, Macdonald RL, De Blas AL, Luscher B, Chen G. γ-Aminobutyric acid type A (GABAA) receptor α subunits play a direct role in synaptic versus extrasynaptic targeting. The Journal of Biological Chemistry. 287: 27417-30. PMID 22711532 DOI: 10.1074/Jbc.M112.360461  0.502
2011 Luscher B, Fuchs T, Kilpatrick CL. GABAA receptor trafficking-mediated plasticity of inhibitory synapses. Neuron. 70: 385-409. PMID 21555068 DOI: 10.1016/J.Neuron.2011.03.024  0.524
2011 Luscher B, Shen Q. Gamma-aminobutyric acidergic deficits cause melancholic depression: a reply to Markou and Geyer. Biological Psychiatry. 69: e13-4; author reply . PMID 21126731 DOI: 10.1016/J.Biopsych.2010.09.054  0.511
2011 Luscher B, Shen Q, Sahir N. The GABAergic deficit hypothesis of major depressive disorder. Molecular Psychiatry. 16: 383-406. PMID 21079608 DOI: 10.1038/Mp.2010.120  0.613
2011 Fomalont K, Earnheart J, Ragan C, Luscher B, Cavigelli S. 217. Correlations between inhibited behavior, HPA axis reactivity, and GABAA receptor concentration in rats Brain, Behavior, and Immunity. 25: S241. DOI: 10.1016/J.Bbi.2011.07.220  0.303
2010 Shen Q, Lal R, Luellen BA, Earnheart JC, Andrews AM, Luscher B. gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression. Biological Psychiatry. 68: 512-20. PMID 20579975 DOI: 10.1016/J.Biopsych.2010.04.024  0.596
2010 Lee K, Porteous R, Campbell RE, Lüscher B, Herbison AE. Knockdown of GABAA receptor signaling in gnrh neurons has minimal effects upon fertility Endocrinology. 151: 4428-4436. PMID 20573723 DOI: 10.1210/En.2010-0314  0.482
2009 Kalscheuer VM, Musante L, Fang C, Hoffmann K, Fuchs C, Carta E, Deas E, Venkateswarlu K, Menzel C, Ullmann R, Tommerup N, Dalprà L, Tzschach A, Selicorni A, Lüscher B, et al. A balanced chromosomal translocation disrupting ARHGEF9 is associated with epilepsy, anxiety, aggression, and mental retardation. Human Mutation. 30: 61-8. PMID 18615734 DOI: 10.1002/Humu.20814  0.597
2008 Yuan X, Yao J, Norris D, Tran DD, Bram RJ, Chen G, Luscher B. Calcium-modulating cyclophilin ligand regulates membrane trafficking of postsynaptic GABA(A) receptors. Molecular and Cellular Neurosciences. 38: 277-89. PMID 18424167 DOI: 10.1016/J.Mcn.2008.03.002  0.687
2007 Deng L, Yao J, Fang C, Dong N, Luscher B, Chen G. Sequential postsynaptic maturation governs the temporal order of GABAergic and glutamatergic synaptogenesis in rat embryonic cultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 10860-9. PMID 17913919 DOI: 10.1523/Jneurosci.2744-07.2007  0.608
2007 Earnheart JC, Schweizer C, Crestani F, Iwasato T, Itohara S, Mohler H, Lüscher B. GABAergic control of adult hippocampal neurogenesis in relation to behavior indicative of trait anxiety and depression states. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3845-54. PMID 17409249 DOI: 10.1523/Jneurosci.3609-06.2007  0.711
2006 Fang C, Deng L, Keller CA, Fukata M, Fukata Y, Chen G, Lüscher B. GODZ-mediated palmitoylation of GABA(A) receptors is required for normal assembly and function of GABAergic inhibitory synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12758-68. PMID 17151279 DOI: 10.1523/Jneurosci.4214-06.2006  0.641
2006 Qi JS, Yao J, Fang C, Luscher B, Chen G. Downregulation of tonic GABA currents following epileptogenic stimulation of rat hippocampal cultures. The Journal of Physiology. 577: 579-90. PMID 16990405 DOI: 10.1113/Jphysiol.2006.113134  0.62
2005 Alldred MJ, Mulder-Rosi J, Lingenfelter SE, Chen G, Lüscher B. Distinct γ2 subunit domains mediate clustering and synaptic function of postsynaptic GABAA receptors and gephyrin Journal of Neuroscience. 25: 594-603. PMID 15659595 DOI: 10.1523/Jneurosci.4011-04.2005  0.745
2004 Lüscher B, Keller CA. Regulation of GABAA receptor trafficking, channel activity, and functional plasticity of inhibitory synapses. Pharmacology & Therapeutics. 102: 195-221. PMID 15246246 DOI: 10.1016/J.Pharmthera.2004.04.003  0.505
2004 Keller CA, Yuan X, Panzanelli P, Martin ML, Alldred M, Sassoè-Pognetto M, Lüscher B. The gamma2 subunit of GABA(A) receptors is a substrate for palmitoylation by GODZ. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 5881-91. PMID 15229235 DOI: 10.1523/Jneurosci.1037-04.2004  0.785
2004 Sinkkonen ST, Lüscher B, Lüddens H, Korpi ER. Autoradiographic imaging of altered synaptic alphabetagamma2 and extrasynaptic alphabeta GABAA receptors in a genetic mouse model of anxiety. Neurochemistry International. 44: 539-47. PMID 15209422 DOI: 10.1016/J.Neuint.2003.08.008  0.504
2003 Schweizer C, Balsiger S, Bluethmann H, Mansuy IM, Fritschy JM, Mohler H, Lüscher B. The gamma 2 subunit of GABA(A) receptors is required for maintenance of receptors at mature synapses. Molecular and Cellular Neurosciences. 24: 442-50. PMID 14572465 DOI: 10.1016/S1044-7431(03)00202-1  0.713
2003 Fritschy JM, Schweizer C, Brünig I, Lüscher B. Pre- and post-synaptic mechanisms regulating the clustering of type A γ-aminobutyric acid receptors (GABAA receptors) Biochemical Society Transactions. 31: 889-892. PMID 12887328 DOI: 10.1042/Bst0310889  0.437
2002 Pannell C, Simonian SX, Gillies GE, Luscher B, Herbison AE. Hypothalamic somatostatin and growth hormone-releasing hormone mRNA expression depend upon GABA(A) receptor expression in the developing mouse. Neuroendocrinology. 76: 93-8. PMID 12169770 DOI: 10.1159/000064428  0.483
2002 Brünig I, Suter A, Knuesel I, Lüscher B, Fritschy JM. GABAergic Terminals Are Required for Postsynaptic Clustering of Dystrophin but Not of GABAA Receptors and Gephyrin Journal of Neuroscience. 22: 4805-4813. PMID 12077177  0.412
2002 Brünig I, Suter A, Knuesel I, Lüscher B, Fritschy J. GABAergic Terminals Are Required for Postsynaptic Clustering of Dystrophin But Not of GABAA Receptors and Gephyrin The Journal of Neuroscience. 22: 4805-4813. DOI: 10.1523/Jneurosci.22-12-04805.2002  0.504
2001 Lüscher B, Keller CA. Ubiquitination, proteasomes and GABAA receptors Nature Cell Biology. 3: E232-E233. PMID 11584285 DOI: 10.1038/Ncb1001-E232  0.472
2001 Lüscher B, Fritschy JM. Subcellular localization and regulation of gabaa receptors and associated proteins International Review of Neurobiology. 48: 35-64. PMID 11526740 DOI: 10.1016/S0074-7742(01)48013-5  0.471
2000 Simonian SX, Skynner MJ, Sieghart W, Essrich C, Luscher B, Herbison AE. Role of the GABA(A) receptor gamma2 subunit in the development of gonadotropin-releasing hormone neurons in vivo. The European Journal of Neuroscience. 12: 3488-96. PMID 11029618 DOI: 10.1046/J.1460-9568.2000.00225.X  0.487
2000 Baer K, Essrich C, Balsiger S, Wick MJ, Harris RA, Fritschy JM, Lüscher B. Rescue of γ2 subunit-deficient mice by transgenic overexpression of the GABA(A) receptor γ2S or γ2L subunit isoforms European Journal of Neuroscience. 12: 2639-2643. PMID 10947838 DOI: 10.1046/J.1460-9568.2000.00159.X  0.511
2000 Lorez M, Benke D, Luscher B, Mohler H, Benson JA. Single-channel properties of neuronal GABAA receptors from mice lacking the 2 subunit. The Journal of Physiology. 527: 11-31. PMID 10944167 DOI: 10.1111/J.1469-7793.2000.T01-1-00011.X  0.701
1998 Essrich C, Lorez M, Benson JA, Fritschy JM, Lüscher B. Postsynaptic clustering of major GABAA receptor subtypes requires the gamma 2 subunit and gephyrin. Nature Neuroscience. 1: 563-71. PMID 10196563 DOI: 10.1038/2798  0.462
1998 Mohler H, Luscher B, Fritschy JM, Benke D, Benson J, Rudolph U. GABA(A)-receptor assembly in vivo: lessons from subunit mutant mice. Life Sciences. 62: 1611-5. PMID 9585145 DOI: 10.1016/S0024-3205(98)00116-7  0.47
1997 Penschuck S, Lüscher B, Fritschy JM, Crestani F. Activation of the GABA(A)-receptor delta-subunit gene promoter following pentylenetetrazole-induced seizures in transgenic mice. Brain Research. Molecular Brain Research. 51: 212-9. PMID 9427523 DOI: 10.1016/S0169-328X(97)00243-X  0.448
1997 Lüscher B, Häuselmann R, Leitgeb S, Rülicke T, Fritschy J. Neuronal subtype-specific expression directed by the GABAA receptor δ subunit gene promoter/upstream region in transgenic mice and in cultured cells Molecular Brain Research. 51: 197-211. PMID 9427522 DOI: 10.1016/S0169-328X(97)00242-8  0.444
1996 Fritschy JM, Brandner S, Aguzzi A, Koedood M, Luscher B, Mitchell PJ. Brain cell type specificity and gliosis-induced activation of the human cytomegalovirus immediate-early promoter in transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 16: 2275-82. PMID 8601807 DOI: 10.1523/Jneurosci.16-07-02275.1996  0.318
1996 Möhler H, Fritschy J-, Benke D, Benson J, Lüscher B. Genetics and function of GABAA-receptor subtypes European Neuropsychopharmacology. 6. DOI: 10.1016/0924-977X(96)82873-2  0.336
1995 Hergersberg M, Matsuo K, Gassmann M, Schaffner W, Lüscher B, Rülicke T, Aguzzi A. Tissue-specific expression of a FMR1/beta-galactosidase fusion gene in transgenic mice. Human Molecular Genetics. 4: 359-66. PMID 7795588 DOI: 10.1093/Hmg/4.3.359  0.553
1995 Gunther U, Benson J, Benke D, Fritschy JM, Reyes G, Knoflach F, Crestani F, Aguzzi A, Arigoni M, Lang Y, Bluethmann H, Mohler H, Luscher B. Benzodiazepine-insensitive mice generated by targeted disruption of the γ2 subunit gene of γ-aminobutyric acid type A receptors Proceedings of the National Academy of Sciences of the United States of America. 92: 7749-7753. PMID 7644489 DOI: 10.1073/Pnas.92.17.7749  0.695
1990 Hu YF, Lüscher B, Adinon A, Mermod N, Tjian R. Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity Genes and Development. 4: 1741-1752. PMID 2123466 DOI: 10.1101/Gad.4.10.1741  0.505
1989 Williams T, Admon A, Lüscher B, Tjian R. Cloning and expression of AP-2, a cell-type-specific transcription factor that activates inducible enhancer elements. Genes & Development. 2: 1557-69. PMID 3063603 DOI: 10.1101/Gad.2.12A.1557  0.518
1989 Lüscher B, Mitchell PJ, Williams T, Tjian R. Regulation of transcription factor AP-2 by the morphogen retinoic acid and by second messengers Genes & Development. 3: 1507-1517. PMID 2482225 DOI: 10.1101/Gad.3.10.1507  0.494
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