| Year |
Citation |
Score |
| 2024 |
Cazzaniga C, Göder A, Rainey MD, Quinlan A, Coughlan S, Bernard S, Santocanale C. CDC7 inhibition drives an inflammatory response and a p53-dependent senescent-like state in breast epithelial cells. The Febs Journal. PMID 38555567 DOI: 10.1111/febs.17127 |
0.365 |
|
| 2023 |
Göder A, Quinlan A, Rainey MD, Bennett D, Shamavu D, Corso J, Santocanale C. PTBP1 enforces ATR-CHK1 signaling determining the potency of CDC7 inhibitors. Iscience. 26: 106951. PMID 37378325 DOI: 10.1016/j.isci.2023.106951 |
0.356 |
|
| 2020 |
Rainey MD, Bennett D, O'Dea R, Zanchetta ME, Voisin M, Seoighe C, Santocanale C. ATR Restrains DNA Synthesis and Mitotic Catastrophe in Response to CDC7 Inhibition. Cell Reports. 32: 108096. PMID 32877678 DOI: 10.1016/J.Celrep.2020.108096 |
0.558 |
|
| 2020 |
Rainey MD, Quinlan A, Cazzaniga C, Mijic S, Martella O, Krietsch J, Göder A, Lopes M, Santocanale C. CDC7 kinase promotes MRE11 fork processing, modulating fork speed and chromosomal breakage. Embo Reports. e48920. PMID 32496651 DOI: 10.15252/Embr.201948920 |
0.524 |
|
| 2020 |
O'Dea R, Santocanale C. Non-canonical regulation of homologous recombination DNA repair by the USP9X deubiquitinase. Journal of Cell Science. PMID 31964704 DOI: 10.1242/Jcs.233437 |
0.56 |
|
| 2017 |
Rainey MD, Quachthithu H, Gaboriau D, Santocanale C. DNA Replication Dynamics and Cellular Responses to ATP Competitive CDC7 Kinase Inhibitors. Acs Chemical Biology. 12: 1893-1902. PMID 28560864 DOI: 10.1021/Acschembio.7B00117 |
0.505 |
|
| 2016 |
Wu KZ, Wang GN, Fitzgerald J, Quachthithu H, Rainey MD, Cattaneo A, Bachi A, Santocanale C. DDK dependent regulation of TOP2A at centromeres revealed by a chemical genetics approach. Nucleic Acids Research. PMID 27407105 DOI: 10.1093/Nar/Gkw626 |
0.47 |
|
| 2016 |
McGarry E, Gaboriau D, Rainey M, Restuccia U, Bachi A, Santocanale C. The deubiquitinase USP9X maintains DNA replication fork stability and DNA damage checkpoint responses by regulating CLASPIN during S-phase. Cancer Research. PMID 26921344 DOI: 10.1158/0008-5472.Can-15-2890 |
0.566 |
|
| 2015 |
O'Connor A, Maffini S, Rainey MD, Kaczmarczyk A, Gaboriau D, Musacchio A, Santocanale C. Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint. Biology Open. PMID 26685311 DOI: 10.1242/Bio.014969 |
0.401 |
|
| 2014 |
FitzGerald J, Murillo LS, O'Brien G, O'Connell E, O'Connor A, Wu K, Wang GN, Rainey MD, Natoni A, Healy S, O'Dwyer M, Santocanale C. A high through-put screen for small molecules modulating MCM2 phosphorylation identifies Ryuvidine as an inducer of the DNA damage response. Plos One. 9: e98891. PMID 24902048 DOI: 10.1371/Journal.Pone.0098891 |
0.527 |
|
| 2013 |
Natoni A, Coyne MR, Jacobsen A, Rainey MD, O'Brien G, Healy S, Montagnoli A, Moll J, O'Dwyer M, Santocanale C. Characterization of a Dual CDC7/CDK9 Inhibitor in Multiple Myeloma Cellular Models. Cancers. 5: 901-18. PMID 24202326 DOI: 10.3390/Cancers5030901 |
0.383 |
|
| 2013 |
Broderick R, Rainey MD, Santocanale C, Nasheuer HP. Cell cycle-dependent formation of Cdc45-Claspin complexes in human cells is compromized by UV-mediated DNA damage. The Febs Journal. 280: 4888-902. PMID 23910567 DOI: 10.1111/Febs.12465 |
0.58 |
|
| 2013 |
Rainey MD, Harhen B, Wang GN, Murphy PV, Santocanale C. Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpoint. Cell Cycle (Georgetown, Tex.). 12: 1560-8. PMID 23598722 DOI: 10.4161/Cc.24675 |
0.494 |
|
| 2012 |
Martin L, Rainey M, Santocanale C, Gardner LB. Hypoxic activation of ATR and the suppression of the initiation of DNA replication through cdc6 degradation. Oncogene. 31: 4076-84. PMID 22179839 DOI: 10.1038/Onc.2011.585 |
0.58 |
|
| 2011 |
Kliszczak AE, Rainey MD, Harhen B, Boisvert FM, Santocanale C. DNA mediated chromatin pull-down for the study of chromatin replication Scientific Reports. 1. PMID 22355613 DOI: 10.1038/Srep00095 |
0.561 |
|
| 2011 |
Natoni A, Murillo LS, Kliszczak AE, Catherwood MA, Montagnoli A, Samali A, O'Dwyer M, Santocanale C. Mechanisms of action of a dual Cdc7/Cdk9 kinase inhibitor against quiescent and proliferating CLL cells. Molecular Cancer Therapeutics. 10: 1624-34. PMID 21768328 DOI: 10.1158/1535-7163.Mct-10-1119 |
0.516 |
|
| 2011 |
Stone JG, Siedlak SL, Tabaton M, Hirano A, Castellani RJ, Santocanale C, Perry G, Smith MA, Zhu X, Lee HG. The cell cycle regulator phosphorylated retinoblastoma protein is associated with tau pathology in several tauopathies. Journal of Neuropathology and Experimental Neurology. 70: 578-87. PMID 21666500 DOI: 10.1097/Nen.0B013E3182204414 |
0.364 |
|
| 2011 |
Napolitano C, Natoni A, Santocanale C, Evensen L, Lorens JB, Murphy PV. Isosteric replacement of the Z-enone with haloethyl ketone and E-enone in a resorcylic acid lactone series and biological evaluation. Bioorganic & Medicinal Chemistry Letters. 21: 1167-70. PMID 21273066 DOI: 10.1016/J.Bmcl.2010.12.100 |
0.311 |
|
| 2010 |
Menichincheri M, Albanese C, Alli C, Ballinari D, Bargiotti A, Caldarelli M, Ciavolella A, Cirla A, Colombo M, Colotta F, Croci V, D'Alessio R, D'Anello M, Ermoli A, Fiorentini F, ... ... Santocanale C, et al. Cdc7 kinase inhibitors: 5-heteroaryl-3-carboxamido-2-aryl pyrroles as potential antitumor agents. 1. Lead finding. Journal of Medicinal Chemistry. 53: 7296-315. PMID 20873740 DOI: 10.1021/Jm100504D |
0.391 |
|
| 2010 |
Swords R, Mahalingam D, O'Dwyer M, Santocanale C, Kelly K, Carew J, Giles F. Cdc7 kinase - a new target for drug development. European Journal of Cancer (Oxford, England : 1990). 46: 33-40. PMID 19815406 DOI: 10.1016/J.Ejca.2009.09.020 |
0.506 |
|
| 2010 |
Colotta F, Moll J, Valsasina B, Vanotti E, Rainoldi S, Sola F, Marchesi V, Menichincheri M, Ciavolella A, Patton V, Albanese C, Volpi D, Avanzi N, Ballinari D, Fiorentini F, ... ... Santocanale C, et al. Abstract DD01-01: NMS-1116354: More than an inhibitor of Cdc 7 kinase in S-phase Cellular and Molecular Biology. 70. DOI: 10.1158/1538-7445.Am10-Dd01-01 |
0.504 |
|
| 2009 |
Bonda DJ, Evans TA, Santocanale C, Llosá JC, Viña J, Bajic V, Castellani RJ, Siedlak SL, Perry G, Smith MA, Lee HG. Evidence for the progression through S-phase in the ectopic cell cycle re-entry of neurons in Alzheimer disease. Aging. 1: 382-8. PMID 19946466 DOI: 10.18632/AGING.100044 |
0.309 |
|
| 2009 |
Menichincheri M, Bargiotti A, Berthelsen J, Bertrand JA, Bossi R, Ciavolella A, Cirla A, Cristiani C, Croci V, D'Alessio R, Fasolini M, Fiorentini F, Forte B, Isacchi A, Martina K, ... ... Santocanale C, et al. First Cdc7 kinase inhibitors: pyrrolopyridinones as potent and orally active antitumor agents. 2. Lead discovery. Journal of Medicinal Chemistry. 52: 293-307. PMID 19115845 DOI: 10.1021/Jm800977Q |
0.407 |
|
| 2009 |
Coyne MRE, Naughton S, Hayden PJ, Montagnoli A, O'Dwyer ME, Santocanale C. Targeting Cdc7 Kinase in Multiple Myeloma. Blood. 114: 3847-3847. DOI: 10.1182/Blood.V114.22.3847.3847 |
0.411 |
|
| 2009 |
Natoni A, Hayat A, Montagnoli A, Callagy G, Samali A, Santocanale C, O'Dwyer MC. PHA767491, a Dual Cdc7/CDK9 Inhibitor, with Potential to Target Both Proliferation and Survival in CLL. Blood. 114: 2366-2366. DOI: 10.1182/Blood.V114.22.2366.2366 |
0.383 |
|
| 2009 |
Krawczyk J, Egan C, Mulvihill M, Webber M, Murillo L, Ingoldsby H, Santocanale C, Callagy G, O'Dwyer MC. Increased Activity of the S Phase Kinase Cdc7 Is Associated with Poor Outcome in Diffuse Large B Cell Lymphoma (DLBCL). Blood. 114: 1914-1914. DOI: 10.1182/Blood.V114.22.1914.1914 |
0.354 |
|
| 2008 |
Montagnoli A, Valsasina B, Croci V, Menichincheri M, Rainoldi S, Marchesi V, Tibolla M, Tenca P, Brotherton D, Albanese C, Patton V, Alzani R, Ciavolella A, Sola F, Molinari A, ... ... Santocanale C, et al. A Cdc7 kinase inhibitor restricts initiation of DNA replication and has antitumor activity. Nature Chemical Biology. 4: 357-65. PMID 18469809 DOI: 10.1038/Nchembio.90 |
0.573 |
|
| 2008 |
Vanotti E, Amici R, Bargiotti A, Berthelsen J, Bosotti R, Ciavolella A, Cirla A, Cristiani C, D'Alessio R, Forte B, Isacchi A, Martina K, Menichincheri M, Molinari A, Montagnoli A, ... ... Santocanale C, et al. Cdc7 kinase inhibitors: Pyrrolopyridinones as potential antitumor agents. 1. Synthesis and structure-activity relationships Journal of Medicinal Chemistry. 51: 487-501. PMID 18201066 DOI: 10.1021/Jm700956R |
0.424 |
|
| 2007 |
Tenca P, Brotherton D, Montagnoli A, Rainoldi S, Albanese C, Santocanale C. Cdc7 is an active kinase in human cancer cells undergoing replication stress. The Journal of Biological Chemistry. 282: 208-15. PMID 17062569 DOI: 10.1074/Jbc.M604457200 |
0.493 |
|
| 2006 |
Montagnoli A, Valsasina B, Brotherton D, Troiani S, Rainoldi S, Tenca P, Molinari A, Santocanale C. Identification of Mcm2 phosphorylation sites by S-phase-regulating kinases. The Journal of Biological Chemistry. 281: 10281-90. PMID 16446360 DOI: 10.1074/Jbc.M512921200 |
0.412 |
|
| 2004 |
Montagnoli A, Tenca P, Sola F, Carpani D, Brotherton D, Albanese C, Santocanale C. Cdc7 inhibition reveals a p53-dependent replication checkpoint that is defective in cancer cells. Cancer Research. 64: 7110-6. PMID 15466207 DOI: 10.1158/0008-5472.Can-04-1547 |
0.489 |
|
| 2002 |
Montagnoli A, Bosotti R, Villa F, Rialland M, Brotherton D, Mercurio C, Berthelsen J, Santocanale C. Drf1, a novel regulatory subunit for human Cdc7 kinase The Embo Journal. 21: 3171-3181. PMID 12065429 DOI: 10.1093/Emboj/Cdf290 |
0.53 |
|
| 2002 |
Rialland M, Sola F, Santocanale C. Essential role of human CDT1 in DNA replication and chromatin licensing. Journal of Cell Science. 115: 1435-40. PMID 11896191 |
0.502 |
|
| 2000 |
Diffley JF, Bousset K, Labib K, Noton EA, Santocanale C, Tercero JA. Coping with and recovering from hydroxyurea-induced replication fork arrest in budding yeast. Cold Spring Harbor Symposia On Quantitative Biology. 65: 333-42. PMID 12760047 DOI: 10.1101/Sqb.2000.65.333 |
0.643 |
|
| 2000 |
Ferreira MF, Santocanale C, Drury LS, Diffley JF. Dbf4p, an essential S phase-promoting factor, is targeted for degradation by the anaphase-promoting complex. Molecular and Cellular Biology. 20: 242-8. PMID 10594027 DOI: 10.1128/Mcb.20.1.242-248.2000 |
0.645 |
|
| 1999 |
Santocanale C, Sharma K, Diffley JF. Activation of dormant origins of DNA replication in budding yeast. Genes & Development. 13: 2360-4. PMID 10500092 DOI: 10.1101/Gad.13.18.2360 |
0.675 |
|
| 1998 |
Santocanale C, Diffley JF. A Mec1- and Rad53-dependent checkpoint controls late-firing origins of DNA replication. Nature. 395: 615-8. PMID 9783589 DOI: 10.1038/27001 |
0.729 |
|
| 1998 |
Desdouets C, Santocanale C, Drury LS, Perkins G, Foiani M, Plevani P, Diffley JF. Evidence for a Cdc6p-independent mitotic resetting event involving DNA polymerase alpha. The Embo Journal. 17: 4139-46. PMID 9670028 DOI: 10.1093/Emboj/17.14.4139 |
0.773 |
|
| 1997 |
Santocanale C, Diffley JF. Genomic footprinting of budding yeast replication origins during the cell cycle. Methods in Enzymology. 283: 377-90. PMID 9251035 DOI: 10.1016/S0076-6879(97)83031-5 |
0.697 |
|
| 1996 |
Cocker JH, Piatti S, Santocanale C, Nasmyth K, Diffley JF. An essential role for the Cdc6 protein in forming the pre-replicative complexes of budding yeast. Nature. 379: 180-2. PMID 8538771 DOI: 10.1038/379180A0 |
0.776 |
|
| 1996 |
Santocanale C, Diffley JFX. ORC- and Cdc6-dependent complexes at active and inactive chromosomal replication origins in Saccharomyces cerevisiae. The Embo Journal. 15: 6671-6679. DOI: 10.1002/J.1460-2075.1996.Tb01057.X |
0.532 |
|
| 1995 |
Santocanale C, Neecke H, Longhese MP, Lucchini G, Plevani P. Mutations in the Gene Encoding the 34 kDa Subunit of Yeast Replication Protein A Cause Defective S Phase Progression Journal of Molecular Biology. 254: 595-607. PMID 7500336 DOI: 10.1006/Jmbi.1995.0641 |
0.774 |
|
| 1992 |
Santocanale C, Locati F, Falconi MM, Piseri A, Tseng BY, Lucchini G, Plevani P. Overproduction and functional analysis of DNA primase subunits from yeast and mouse. Gene. 113: 199-205. PMID 1572541 DOI: 10.1016/0378-1119(92)90396-7 |
0.753 |
|
| 1991 |
Francesconi S, Longhese MP, Piseri A, Santocanale C, Lucchini G, Plevani P. Mutations in conserved yeast DNA primase domains impair DNA replication in vivo. Proceedings of the National Academy of Sciences of the United States of America. 88: 3877-3881. PMID 2023935 DOI: 10.1073/Pnas.88.9.3877 |
0.785 |
|
| 1989 |
Plevani P, Foiani M, Muzi Falconi M, Pizzagalli A, Santocanale C, Francesconi S, Valsasnini P, Comedini A, Piatti S, Lucchini G. The yeast DNA polymerase-primase complex: genes and proteins. Biochimica Et Biophysica Acta. 951: 268-73. PMID 3061469 DOI: 10.1016/0167-4781(88)90096-6 |
0.748 |
|
| 1989 |
Foiani M, Santocanale C, Plevani P, Lucchini G. A single essential gene, PRI2, encodes the large subunit of DNA primase in Saccharomyces cerevisiae. Molecular and Cellular Biology. 9: 3081-3087. PMID 2528682 DOI: 10.1128/Mcb.9.7.3081 |
0.792 |
|
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