Area:
Cognition, Alzheimer's Disease, Vascular Cognitive Impairment, Stress and Vascular Disease, Oxytocin
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High-probability grants
According to our matching algorithm, Daniel A. Nation is the likely recipient of the following grants.
| Years |
Recipients |
Code |
Title / Keywords |
Matching
score |
| 2017 — 2018 |
Nation, Daniel A |
R21Activity Code Description:
To encourage the development of new research activities in categorical program areas. (Support generally is restricted in level of support and in time.) |
Vascular Reserve and Protective Mechanisms in Aging and Alzheimer?S Dementia Risk @ University of Southern California
Project Abstract Vascular risk factors are risk factors for Alzheimer?s and vascular dementia, the two leading causes of dementia, and cerebrovascular disease is found in the brains of both Alzheimer?s and vascular dementia patients at autopsy. Less is known about vascular protective factors in dementia, but protective vascular factors are known to modify cardiovascular disease risk. The current proposal focuses on vascular protective factors and introduces the concept of ?vascular reserve?, which is defined by the degree of protection from cognitive decline conveyed by protective vascular factors. The research will entail study of two major protective factors: 1) endothelial progenitor cells (EPCs) that circulate in the blood stream to repair and maintain blood vessel integrity and function and 2) renin-angiotensin system (RAS) peptides that protect vessels from oxidative and inflammatory injury through multiple pathways. The study will examine whether these protective factors are associated with improved brain blood flow, less brain vascular disease, larger brain volumes within vulnerable regions, and better cognitive performance in older adults with vascular risk factors. If these factors protect against these risk indicators for dementia then they may open new avenues for risk assessment and targeted prevention.
|
0.976 |
| 2019 — 2021 |
Nation, Daniel A |
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Cerebrovascular Resistance in Cognitive Aging and Alzheimer's Disease Risk @ University of Southern California
Project Summary The proposed study will investigate the role of cerebrovascular dysfunction during the earliest stages of neurocognitive decline, prior to any obvious changes in cognition. Specifically, we will study whether cognitively normal older adults at risk for Alzheimer's disease show increased cerebrovascular resistance. We will also study how increased cerebrovascular resistance relates to brain dysfunction using functional brain scans. Finally, we will investigate whether higher cerebrovascular resistance in cognitively normal older adults predicts development of subtle cognitive decline over a two year follow-up interval.
|
0.981 |
| 2019 — 2021 |
Nation, Daniel A |
R01Activity Code Description:
To support a discrete, specified, circumscribed project to be performed by the named investigator(s) in an area representing his or her specific interest and competencies. |
Endothelial Progenitor Cells and Neurovascular Injury in the Aging Brain @ University of California-Irvine
Project Summary The proposed study will investigate the role of endothelial progenitor cells in neurovascular dysfunction and cognitive decline among older adults with low levels of traditional vascular risk and normal baseline cognitive function. Specifically, we will study whether changes in endothelial progenitor cell proliferation and senescence are predictive of cognitive decline, vascular brain lesions and structural and functional brain connectivity. We will also study secretory factors from endothelial progenitor cell cultures to better understand how progenitor cell function relates to neurovascular dysfunction, brain injury and cognitive decline.
|
0.981 |