| Year |
Citation |
Score |
| 2020 |
Bagheri H, Friedman H, Siminovitch KA, Peterson AC. Transcriptional regulators of the Golli/myelin basic protein locus integrate additive and stealth activities. Plos Genetics. 16: e1008752. PMID 32790717 DOI: 10.1371/Journal.Pgen.1008752 |
0.346 |
|
| 2019 |
Lee KS, Kronbichler A, Pereira Vasconcelos DF, Pereira da Silva FR, Ko Y, Oh YS, Eisenhut M, Merkel PA, Jayne D, Amos CI, Siminovitch KA, Rahmattulla C, Lee KH, Shin JI. Genetic Variants in Antineutrophil Cytoplasmic Antibody-Associated Vasculitis: A Bayesian Approach and Systematic Review. Journal of Clinical Medicine. 8. PMID 30795559 DOI: 10.3390/Jcm8020266 |
0.334 |
|
| 2016 |
Merkel PA, Xie G, Monach PA, Ji X, Ciavatta DJ, Byun J, Pinder BD, Zhao A, Zhang J, Tadesse Y, Qian D, Weirauch M, Nair R, Tsoi A, Pagnoux C, ... ... Siminovitch KA, et al. Identification of functional and expression polymorphisms associated with risk for anti-neutrophil cytoplasmic autoantibody-associated vasculitis. Arthritis & Rheumatology (Hoboken, N.J.). PMID 28029757 DOI: 10.1002/Art.40034 |
0.32 |
|
| 2015 |
Webb G, Siminovitch KA, Hirschfield GM. The immunogenetics of primary biliary cirrhosis: A comprehensive review. Journal of Autoimmunity. 64: 42-52. PMID 26250073 DOI: 10.1016/J.Jaut.2015.07.004 |
0.4 |
|
| 2015 |
Kottyan LC, Zoller EE, Bene J, Lu X, Kelly JA, Rupert AM, Lessard CJ, Vaughn SE, Marion M, Weirauch MT, Namjou B, Adler A, Rasmussen A, Glenn S, Montgomery CG, ... ... Siminovitch K, et al. The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share. Human Molecular Genetics. 24: 582-96. PMID 25205108 DOI: 10.1093/Hmg/Ddu455 |
0.368 |
|
| 2015 |
Hirschfield GM, Siminovitch KA. Genetics in PBC: what do the "risk genes" teach us? Clinical Reviews in Allergy & Immunology. 48: 176-81. PMID 24744192 DOI: 10.1007/S12016-014-8419-X |
0.385 |
|
| 2015 |
Gazal S, Sacre K, Allanore Y, Teruel M, Goodall AH, Tohma S, Alfredsson L, Okada Y, Xie G, Constantin A, Balsa A, Kawasaki A, Nicaise P, Amos C, ... ... Siminovitch K, et al. Identification of secreted phosphoprotein 1 gene as a new rheumatoid arthritis susceptibility gene. Annals of the Rheumatic Diseases. 74: e19. PMID 24448344 DOI: 10.1136/Annrheumdis-2013-204581 |
0.302 |
|
| 2014 |
Roussos P, Mitchell AC, Voloudakis G, Fullard JF, Pothula VM, Tsang J, Stahl EA, Georgakopoulos A, Ruderfer DM, Charney A, Okada Y, Siminovitch KA, Worthington J, Padyukov L, Klareskog L, et al. A role for noncoding variation in schizophrenia. Cell Reports. 9: 1417-29. PMID 25453756 DOI: 10.1016/J.Celrep.2014.10.015 |
0.304 |
|
| 2014 |
Thompson MD, Cole DE, Capra V, Siminovitch KA, Rovati GE, Burnham WM, Rana BK. Pharmacogenetics of the G protein-coupled receptors. Methods in Molecular Biology (Clifton, N.J.). 1175: 189-242. PMID 25150871 DOI: 10.1007/978-1-4939-0956-8_9 |
0.316 |
|
| 2014 |
Kung TN, Dennis J, Ma Y, Xie G, Bykerk V, Pope J, Thorne C, Keystone E, Siminovitch KA, Gagnon F. RFC1 80G>A is a genetic determinant of methotrexate efficacy in rheumatoid arthritis: a human genome epidemiologic review and meta-analysis of observational studies. Arthritis & Rheumatology (Hoboken, N.J.). 66: 1111-20. PMID 24782176 DOI: 10.1002/Art.38331 |
0.304 |
|
| 2014 |
Okada Y, Diogo D, Greenberg JD, Mouassess F, Achkar WA, Fulton RS, Denny JC, Gupta N, Mirel D, Gabriel S, Li G, Kremer JM, Pappas DA, Carroll RJ, Eyler AE, ... ... Siminovitch KA, et al. Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene. Plos One. 9: e87645. PMID 24520335 DOI: 10.1371/Journal.Pone.0087645 |
0.313 |
|
| 2014 |
Okada Y, Wu D, Trynka G, Raj T, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Yoshida S, Graham RR, Manoharan A, Ortmann W, Bhangale T, Denny JC, ... ... Siminovitch KA, et al. Genetics of rheumatoid arthritis contributes to biology and drug discovery. Nature. 506: 376-81. PMID 24390342 DOI: 10.1038/Nature12873 |
0.322 |
|
| 2013 |
Dong B, Zhang SS, Gao W, Su H, Chen J, Jin F, Bhargava A, Chen X, Jorgensen L, Alberts AS, Zhang J, Siminovitch KA. Mammalian diaphanous-related formin 1 regulates GSK3β-dependent microtubule dynamics required for T cell migratory polarization. Plos One. 8: e80500. PMID 24260404 DOI: 10.1371/Journal.Pone.0080500 |
0.382 |
|
| 2013 |
Li G, Diogo D, Wu D, Spoonamore J, Dancik V, Franke L, Kurreeman F, Rossin EJ, Duclos G, Hartland C, Zhou X, Li K, Liu J, De Jager PL, Siminovitch KA, et al. Human genetics in rheumatoid arthritis guides a high-throughput drug screen of the CD40 signaling pathway. Plos Genetics. 9: e1003487. PMID 23696745 DOI: 10.1371/Journal.Pgen.1003487 |
0.323 |
|
| 2013 |
Diogo D, Kurreeman F, Stahl EA, Liao KP, Gupta N, Greenberg JD, Rivas MA, Hickey B, Flannick J, Thomson B, Guiducci C, Ripke S, Adzhubey I, Barton A, Kremer JM, ... ... Siminovitch KA, et al. Rare, low-frequency, and common variants in the protein-coding sequence of biological candidate genes from GWASs contribute to risk of rheumatoid arthritis. American Journal of Human Genetics. 92: 15-27. PMID 23261300 DOI: 10.1016/J.Ajhg.2012.11.012 |
0.302 |
|
| 2013 |
Xie G, Lu Y, Sun Y, Zhang SS, Keystone EC, Gregersen PK, Plenge RM, Amos CI, Siminovitch KA. Identification of the NF-κB activating protein-like locus as a risk locus for rheumatoid arthritis. Annals of the Rheumatic Diseases. 72: 1249-54. PMID 23223422 DOI: 10.1136/Annrheumdis-2012-202076 |
0.33 |
|
| 2012 |
Juran BD, Hirschfield GM, Invernizzi P, Atkinson EJ, Li Y, Xie G, Kosoy R, Ransom M, Sun Y, Bianchi I, Schlicht EM, Lleo A, Coltescu C, Bernuzzi F, Podda M, ... ... Siminovitch KA, et al. Immunochip analyses identify a novel risk locus for primary biliary cirrhosis at 13q14, multiple independent associations at four established risk loci and epistasis between 1p31 and 7q32 risk variants. Human Molecular Genetics. 21: 5209-21. PMID 22936693 DOI: 10.1093/Hmg/Dds359 |
0.334 |
|
| 2012 |
Chung SA, Xie G, Roshandel D, Sherva R, Edberg JC, Kravitz M, Dellaripa PF, Hoffman GS, Mahr AD, Seo P, Specks U, Spiera RF, St Clair EW, Stone JH, Plenge RM, ... Siminovitch KA, et al. Meta-analysis of genetic polymorphisms in granulomatosis with polyangiitis (Wegener's) reveals shared susceptibility loci with rheumatoid arthritis. Arthritis and Rheumatism. 64: 3463-71. PMID 22508400 DOI: 10.1002/Art.34496 |
0.34 |
|
| 2012 |
Okada Y, Terao C, Ikari K, Kochi Y, Ohmura K, Suzuki A, Kawaguchi T, Stahl EA, Kurreeman FA, Nishida N, Ohmiya H, Myouzen K, Takahashi M, Sawada T, Nishioka Y, ... ... Siminovitch KA, et al. Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population. Nature Genetics. 44: 511-6. PMID 22446963 DOI: 10.1038/Ng.2231 |
0.31 |
|
| 2012 |
Stahl EA, Wegmann D, Trynka G, Gutierrez-Achury J, Do R, Voight BF, Kraft P, Chen R, Kallberg HJ, Kurreeman FA, Kathiresan S, Wijmenga C, Gregersen PK, ... ... Siminovitch KA, et al. Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis. Nature Genetics. 44: 483-9. PMID 22446960 DOI: 10.1038/Ng.2232 |
0.336 |
|
| 2012 |
Martini M, Ferrara AM, Giachelia M, Panieri E, Siminovitch K, Galeotti T, Larocca LM, Pani G. Association of the OCTN1/1672T variant with increased risk for colorectal cancer in young individuals and ulcerative colitis patients Inflammatory Bowel Diseases. 18: 439-448. PMID 21793125 DOI: 10.1002/Ibd.21814 |
0.329 |
|
| 2011 |
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S, Kavousi M, Baumeister SE, Coin LJ, Deng G, Gieger C, Heard-Costa NL, Hottenga JJ, ... ... Siminovitch KA, et al. Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma. Nature Genetics. 43: 1131-8. PMID 22001757 DOI: 10.1038/Ng.970 |
0.305 |
|
| 2011 |
Zhang J, Zahir N, Jiang Q, Miliotis H, Heyraud S, Meng X, Dong B, Xie G, Qiu F, Hao Z, McCulloch CA, Keystone EC, Peterson AC, Siminovitch KA. The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness. Nature Genetics. 43: 902-7. PMID 21841778 DOI: 10.1038/Ng.904 |
0.689 |
|
| 2011 |
Mkhikian H, Grigorian A, Li CF, Chen HL, Newton B, Zhou RW, Beeton C, Torossian S, Tatarian GG, Lee SU, Lau K, Walker E, Siminovitch KA, Chandy KG, Yu Z, et al. Genetics and the environment converge to dysregulate N-glycosylation in multiple sclerosis. Nature Communications. 2: 334. PMID 21629267 DOI: 10.1038/Ncomms1333 |
0.307 |
|
| 2011 |
Jin F, Dong B, Georgiou J, Jiang Q, Zhang J, Bharioke A, Qiu F, Lommel S, Feltri ML, Wrabetz L, Roder JC, Eyer J, Chen X, Peterson AC, Siminovitch KA. N-WASp is required for Schwann cell cytoskeletal dynamics, normal myelin gene expression and peripheral nerve myelination. Development (Cambridge, England). 138: 1329-37. PMID 21385763 DOI: 10.1242/Dev.058677 |
0.729 |
|
| 2011 |
Zhernakova A, Stahl EA, Trynka G, Raychaudhuri S, Festen EA, Franke L, Westra HJ, Fehrmann RS, Kurreeman FA, Thomson B, Gupta N, Romanos J, McManus R, Ryan AW, Turner G, ... ... Siminovitch KA, et al. Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci. Plos Genetics. 7: e1002004. PMID 21383967 DOI: 10.1371/Journal.Pgen.1002004 |
0.351 |
|
| 2011 |
Daha NA, Willemze A, Robinson DB, Oen KG, Smolik I, Hart D, Ghidey W, Houwing-Duistermaat JJ, Siminovitch K, Huizinga TW, El-Gabalawy HS, Toes RE. Genetic interaction in the susceptibility of rheumatoid arthritis Annals of the Rheumatic Diseases. 70: A84-A84. DOI: 10.1136/Ard.2010.149021.5 |
0.32 |
|
| 2009 |
Gregersen PK, Amos CI, Lee AT, Lu Y, Remmers EF, Kastner DL, Seldin MF, Criswell LA, Plenge RM, Holers VM, Mikuls TR, Sokka T, Moreland LW, Bridges SL, Xie G, ... ... Siminovitch KA, et al. REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis. Nature Genetics. 41: 820-3. PMID 19503088 DOI: 10.1038/Ng.395 |
0.314 |
|
| 2009 |
Walker EJ, Hirschfield GM, Xu C, Lu Y, Liu X, Lu Y, Coltescu C, Wang K, Newman WG, Bykerk V, Keystone EC, Mosher D, Amos CI, Heathcote EJ, Siminovitch KA. CTLA4/ICOS gene variants and haplotypes are associated with rheumatoid arthritis and primary biliary cirrhosis in the Canadian population. Arthritis and Rheumatism. 60: 931-7. PMID 19333938 DOI: 10.1002/Art.24412 |
0.359 |
|
| 2009 |
Shi Y, Zhang J, Mullin M, Dong B, Alberts AS, Siminovitch KA. The mDial formin is required for neutrophil polarization, migration, and activation of the LARG/RhoA/ROCK signaling axis during chemotaxis. Journal of Immunology (Baltimore, Md. : 1950). 182: 3837-45. PMID 19265163 DOI: 10.4049/Jimmunol.0803838 |
0.394 |
|
| 2009 |
Shi Y, Dong B, Miliotis H, Liu J, Alberts AS, Zhang J, Siminovitch KA. Src kinase Hck association with the WASp and mDia1 cytoskeletal regulators promotes chemoattractant-induced Hck membrane targeting and activation in neutrophils. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 87: 207-16. PMID 19234535 DOI: 10.1139/O08-130 |
0.681 |
|
| 2007 |
Walker EJ, Siminovitch KA. Primer: genomic and proteomic tools for the molecular dissection of disease. Nature Clinical Practice. Rheumatology. 3: 580-9. PMID 17906613 DOI: 10.1038/Ncprheum0595 |
0.325 |
|
| 2007 |
Eisenmann KM, West RA, Hildebrand D, Kitchen SM, Peng J, Sigler R, Zhang J, Siminovitch KA, Alberts AS. T cell responses in mammalian diaphanous-related formin mDia1 knock-out mice. The Journal of Biological Chemistry. 282: 25152-8. PMID 17595162 DOI: 10.1074/Jbc.M703243200 |
0.393 |
|
| 2007 |
Pao LI, Badour K, Siminovitch KA, Neel BG. Nonreceptor protein-tyrosine phosphatases in immune cell signaling. Annual Review of Immunology. 25: 473-523. PMID 17291189 DOI: 10.1146/Annurev.Immunol.23.021704.115647 |
0.35 |
|
| 2007 |
Badour K, McGavin MK, Zhang J, Freeman S, Vieira C, Filipp D, Julius M, Mills GB, Siminovitch KA. Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. Proceedings of the National Academy of Sciences of the United States of America. 104: 1593-8. PMID 17242350 DOI: 10.1073/Pnas.0610543104 |
0.329 |
|
| 2006 |
Milkiewicz P, Pache I, Buwaneswaran H, Liu X, Coltescu C, Heathcote EJ, Siminovitch KA. The PTPN22 1858T variant is not associated with primary biliary cirrhosis Tissue Antigens. 67: 434-437. PMID 16671954 DOI: 10.1111/J.1399-0039.2006.00594.X |
0.354 |
|
| 2006 |
Newman WG, Gu X, Wintle RF, Liu X, van Oene M, Amos CI, Siminovitch KA. DLG5 variants contribute to Crohn disease risk in a Canadian population. Human Mutation. 27: 353-8. PMID 16450402 DOI: 10.1002/Humu.20301 |
0.352 |
|
| 2005 |
Forget G, Matte C, Siminovitch KA, Rivest S, Pouliot P, Olivier M. Regulation of the Leishmania-induced innate inflammatory response by the protein tyrosine phosphatase SHP-1. European Journal of Immunology. 35: 1906-17. PMID 15902687 DOI: 10.1002/Eji.200526037 |
0.336 |
|
| 2005 |
Newman B, Gu X, Wintle R, Cescon D, Yazdanpanah M, Liu X, Peltekova V, Van Oene M, Amos CI, Siminovitch KA. A risk haplotype in the Solute Carrier Family 22A4/22A5 gene cluster influences phenotypic expression of Crohn's disease. Gastroenterology. 128: 260-9. PMID 15685536 DOI: 10.1053/J.Gastro.2004.11.056 |
0.333 |
|
| 2004 |
Morales-Tirado V, Johannson S, Hanson E, Howell A, Zhang J, Siminovitch KA, Fowell DJ. Cutting edge: selective requirement for the Wiskott-Aldrich syndrome protein in cytokine, but not chemokine, secretion by CD4+ T cells. Journal of Immunology (Baltimore, Md. : 1950). 173: 726-30. PMID 15240657 DOI: 10.4049/Jimmunol.173.2.726 |
0.354 |
|
| 2004 |
Majstoravich S, Zhang J, Nicholson-Dykstra S, Linder S, Friedrich W, Siminovitch KA, Higgs HN. Lymphocyte microvilli are dynamic, actin-dependent structures that do not require Wiskott-Aldrich syndrome protein (WASp) for their morphology. Blood. 104: 1396-403. PMID 15130947 DOI: 10.1182/Blood-2004-02-0437 |
0.341 |
|
| 2004 |
Peltekova VD, Wintle RF, Rubin LA, Amos CI, Huang Q, Gu X, Newman B, Van Oene M, Cescon D, Greenberg G, Griffiths AM, St George-Hyslop PH, Siminovitch KA. Functional variants of OCTN cation transporter genes are associated with Crohn disease. Nature Genetics. 36: 471-5. PMID 15107849 DOI: 10.1038/Ng1339 |
0.335 |
|
| 2004 |
Newman B, Silverberg MS, Gu X, Zhang Q, Lazaro A, Steinhart AH, Greenberg GR, Griffiths AM, McLeod RS, Cohen Z, Fernández-Viña M, Amos CI, Siminovitch K. CARD15 and HLA DRB1 alleles influence susceptibility and disease localization in Crohn's disease. The American Journal of Gastroenterology. 99: 306-15. PMID 15046222 DOI: 10.1111/J.1572-0241.2004.04038.X |
0.31 |
|
| 2004 |
Badour K, Zhang J, Shi F, Leng Y, Collins M, Siminovitch KA. Fyn and PTP-PEST-mediated regulation of Wiskott-Aldrich syndrome protein (WASp) tyrosine phosphorylation is required for coupling T cell antigen receptor engagement to WASp effector function and T cell activation. The Journal of Experimental Medicine. 199: 99-112. PMID 14707117 DOI: 10.1084/Jem.20030976 |
0.424 |
|
| 2003 |
MacGillivray M, Herrera-Abreu MT, Chow CW, Shek C, Wang Q, Vachon E, Feng GS, Siminovitch KA, McCulloch CA, Downey GP. The protein tyrosine phosphatase SHP-2 regulates interleukin-1-induced ERK activation in fibroblasts. The Journal of Biological Chemistry. 278: 27190-8. PMID 12721296 DOI: 10.1074/Jbc.M213083200 |
0.312 |
|
| 2003 |
Crow AR, Song S, Freedman J, Helgason CD, Humphries RK, Siminovitch KA, Lazarus AH. IVIg-mediated amelioration of murine ITP via FcgammaRIIB is independent of SHIP1, SHP-1, and Btk activity. Blood. 102: 558-60. PMID 12649142 DOI: 10.1182/Blood-2003-01-0023 |
0.408 |
|
| 2003 |
Badour K, Zhang J, Shi F, McGavin MK, Rampersad V, Hardy LA, Field D, Siminovitch KA. The Wiskott-Aldrich syndrome protein acts downstream of CD2 and the CD2AP and PSTPIP1 adaptors to promote formation of the immunological synapse. Immunity. 18: 141-54. PMID 12530983 DOI: 10.1016/S1074-7613(02)00516-2 |
0.34 |
|
| 2002 |
Zhang J, Shi F, Badour K, Deng Y, McGavin MK, Siminovitch KA. WASp verprolin homology, cofilin homology, and acidic region domain-mediated actin polymerization is required for T cell development. Proceedings of the National Academy of Sciences of the United States of America. 99: 2240-5. PMID 11842211 DOI: 10.1073/Pnas.042686099 |
0.393 |
|
| 2001 |
McGavin MKH, Badour K, Hardy LA, Kubiseski TJ, Zhang J, Siminovitch KA. The intersectin 2 adaptor links Wiskott Aldrich Syndrome protein (WASp)-mediated actin polymerization to T cell antigen receptor endocytosis. Journal of Experimental Medicine. 194: 1777-1787. PMID 11748279 DOI: 10.1084/Jem.194.12.1777 |
0.414 |
|
| 2001 |
Forget G, Siminovitch KA, Brochu S, Rivest S, Radzioch D, Olivier M. Role of host phosphotyrosine phosphatase SHP-1 in the development of murine leishmaniasis. European Journal of Immunology. 31: 3185-96. PMID 11745335 DOI: 10.1002/1521-4141(200111)31:11<3185::Aid-Immu3185>3.0.Co;2-J |
0.337 |
|
| 2001 |
Rioux JD, Daly MJ, Silverberg MS, Lindblad K, Steinhart H, Cohen Z, Delmonte T, Kocher K, Miller K, Guschwan S, Kulbokas EJ, O'Leary S, Winchester E, Dewar K, Green T, ... ... Siminovitch KA, et al. Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn disease. Nature Genetics. 29: 223-8. PMID 11586304 DOI: 10.1038/Ng1001-223 |
0.314 |
|
| 2001 |
Silverberg MS, Clelland C, Murphy JE, Steinhart AH, McLeod RS, Greenberg GR, Cohen Z, Siminovitch KA. Carrier rate of APC I1307K is not increased in inflammatory bowel disease patients of Ashkenazi Jewish origin. Human Genetics. 108: 205-10. PMID 11354631 DOI: 10.1007/S004390100474 |
0.303 |
|
| 2000 |
Kruger J, Butler JR, Cherapanov V, Dong Q, Ginzberg H, Govindarajan A, Grinstein S, Siminovitch KA, Downey GP. Deficiency of Src homology 2-containing phosphatase 1 results in abnormalities in murine neutrophil function: studies in motheaten mice. Journal of Immunology (Baltimore, Md. : 1950). 165: 5847-59. PMID 11067945 DOI: 10.4049/Jimmunol.165.10.5847 |
0.401 |
|
| 2000 |
Zhang J, Somani AK, Siminovitch KA. Roles of the SHP-1 tyrosine phosphatase in the negative regulation of cell signalling. Seminars in Immunology. 12: 361-78. PMID 10995583 DOI: 10.1006/Smim.2000.0223 |
0.385 |
|
| 2000 |
Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, McLeod RS, Griffiths AM, Green T, Brettin TS, Stone V, Bull SB, Bitton A, Williams CN, Greenberg GR, Cohen Z, Lander ES, ... ... Siminovitch KA, et al. Genomewide search in Canadian families with inflammatory bowel disease reveals two novel susceptibility loci. American Journal of Human Genetics. 66: 1863-70. PMID 10777714 DOI: 10.1086/302913 |
0.309 |
|
| 2000 |
da Cruz LA, Penfold S, Zhang J, Somani AK, Shi F, McGavin MK, Song X, Siminovitch KA. Involvement of the lymphocyte cytoskeleton in antigen-receptor signaling. Current Topics in Microbiology and Immunology. 245: 135-67. PMID 10533312 DOI: 10.1007/978-3-642-57066-7_4 |
0.315 |
|
| 1999 |
Zhang J, Shehabeldin A, da Cruz LA, Butler J, Somani AK, McGavin M, Kozieradzki I, dos Santos AO, Nagy A, Grinstein S, Penninger JM, Siminovitch KA. Antigen receptor-induced activation and cytoskeletal rearrangement are impaired in Wiskott-Aldrich syndrome protein-deficient lymphocytes. The Journal of Experimental Medicine. 190: 1329-42. PMID 10544204 DOI: 10.1084/Jem.190.9.1329 |
0.423 |
|
| 1999 |
Cuevas B, Lu Y, Watt S, Kumar R, Zhang J, Siminovitch KA, Mills GB. SHP-1 regulates Lck-induced phosphatidylinositol 3-kinase phosphorylation and activity. Journal of Biological Chemistry. 274: 27583-27589. PMID 10488096 DOI: 10.1074/Jbc.274.39.27583 |
0.394 |
|
| 1999 |
Siminovitch KA, Lamhonwah AM, Somani AK, Cardiff R, Mills GB. Involvement of the SHP-1 tyrosine phosphatase in regulating B lymphocyte antigen receptor signaling, proliferation and transformation. Current Topics in Microbiology and Immunology. 246: 291-7; discussion 29. PMID 10396068 DOI: 10.1007/978-3-642-60162-0_36 |
0.416 |
|
| 1998 |
Siminovitch KA, Neel BG. Regulation of B cell signal transduction by SH2-containing protein–tyrosine phosphatases Seminars in Immunology. 10: 329-347. PMID 9695189 DOI: 10.1006/Smim.1998.0125 |
0.376 |
|
| 1997 |
Somani AK, Bignon JS, Mills GB, Siminovitch KA, Branch DR. Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase. The Journal of Biological Chemistry. 272: 21113-9. PMID 9261115 DOI: 10.1074/Jbc.272.34.21113 |
0.387 |
|
| 1997 |
Pani G, Siminovitch KA, Paige CJ. The motheaten mutation rescues B cell signaling and development in CD45-deficient mice. The Journal of Experimental Medicine. 186: 581-8. PMID 9254656 DOI: 10.1084/Jem.186.4.581 |
0.346 |
|
| 1997 |
Pani G, Siminovitch KA. Protein Tyrosine Phosphatase Roles in the Regulation of Lymphocyte Signaling Clinical Immunology and Immunopathology. 84: 1-16. PMID 9191879 DOI: 10.1006/Clin.1996.4326 |
0.342 |
|
| 1997 |
Brumell JH, Chan CK, Butler J, Borregaard N, Siminovitch KA, Grinstein S, Downey GP. Regulation of Src homology 2-containing tyrosine phosphatase 1 during activation of human neutrophils: Role of protein kinase C Journal of Biological Chemistry. 272: 875-882. PMID 8995376 DOI: 10.1074/Jbc.272.2.875 |
0.367 |
|
| 1996 |
Pani G, Fischer KD, Mlinaric-Rascan I, Siminovitch KA. Signaling capacity of the T cell antigen receptor is negatively regulated by the PTP1C tyrosine phosphatase. The Journal of Experimental Medicine. 184: 839-52. PMID 9064344 DOI: 10.1084/Jem.184.3.839 |
0.426 |
|
| 1996 |
Greer WL, Shehabeldin A, Schulman J, Junker A, Siminovitch KA. Identification of WASP mutations, mutation hotspots and genotype-phenotype disparities in 24 patients with the Wiskott-Aldrich syndrome. Human Genetics. 98: 685-90. PMID 8931701 DOI: 10.1007/S004390050285 |
0.301 |
|
| 1995 |
Huang DF, Siminovitch KA, Liu XY, Olee T, Olsen NJ, Berry C, Carson DA, Chen PP. Population and family studies of three disease-related polymorphic genes in systemic lupus erythematosus. The Journal of Clinical Investigation. 95: 1766-72. PMID 7706484 DOI: 10.1172/Jci117854 |
0.342 |
|
| 1995 |
Pani G, Kozlowski M, Cambier JC, Mills GB, Siminovitch KA. Identification of the tyrosine phosphatase PTP1C as a B cell antigen receptor-associated protein involved in the regulation of B cell signaling. The Journal of Experimental Medicine. 181: 2077-84. PMID 7539038 DOI: 10.1084/Jem.181.6.2077 |
0.425 |
|
| 1994 |
Bignon JS, Siminovitch KA. Identification of PTP1C mutation as the genetic defect in motheaten and viable motheaten mice: a step toward defining the roles of protein tyrosine phosphatases in the regulation of hemopoietic cell differentiation and function. Clinical Immunology and Immunopathology. 73: 168-179. PMID 7923924 DOI: 10.1006/Clin.1994.1185 |
0.399 |
|
| 1994 |
Greer WL, Siminovitch KA. Molecular characterization of the X-linked immunodeficiency diseases Clinical Immunology Newsletter. 14: 17-25. DOI: 10.1016/0197-1859(94)90039-6 |
0.331 |
|
| 1993 |
Tsui HW, Siminovitch KA, de Souza L, Tsui FWL. Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene Nature Genetics. 4: 124-129. PMID 8348149 DOI: 10.1038/Ng0693-124 |
0.362 |
|
| 1993 |
Yuh K, Siminovitch KA, Ochi A. T cell anergy is programmed early after exposure to bacterial superantigen in vivo International Immunology. 5: 1375-1382. PMID 8260451 DOI: 10.1093/Intimm/5.11.1375 |
0.344 |
|
| 1993 |
Kozlowski M, Mlinaric-Rascan I, Feng G, Shen R, Pawson T, Siminovitch KA. Expression and catalytic activity of the tyrosine phosphatase PTP1C is severely impaired in motheaten and viable motheaten mice. Journal of Experimental Medicine. 178: 2157-2163. PMID 8245788 DOI: 10.1084/Jem.178.6.2157 |
0.346 |
|
| 1992 |
Simon HU, Mills GB, Hashimoto S, Siminovitch KA. Evidence for defective transmembrane signaling in B cells from patients with Wiskott-Aldrich syndrome. Journal of Clinical Investigation. 90: 1396-1405. PMID 1401074 DOI: 10.1172/Jci116006 |
0.383 |
|
| 1990 |
Siminovitch KA, Chen PP. The biologic significance of human natural autoimmune responses: Relationship to the germline, early immune and malignant b cell variable gene repertoire International Reviews of Immunology. 5: 265-277. PMID 2130121 DOI: 10.3109/08830189009056734 |
0.321 |
|
| 1989 |
Greer WL, Higgins E, Sutherland DR, Novogrodsky A, Brockhausen I, Peacocke M, Rubin LA, Baker M, Dennis JW, Siminovitch KA. Altered expression of leucocyte sialoglycoprotein in Wiskott-Aldrich syndrome is associated with a specific defect in O-glycosylation. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 67: 503-9. PMID 2803729 DOI: 10.1139/O89-081 |
0.338 |
|
| 1989 |
Lauzon RJ, Siminovitch KA, Roder JC. The role of T cell receptors in non-MHC-restricted cytotoxicity. Cellular Immunology. 118: 265-84. PMID 2521308 DOI: 10.1016/0008-8749(89)90377-8 |
0.332 |
|
| 1986 |
Lauzon RJ, Siminovitch KA, Fulop GM, Phillips RA, Roder JC. An expanded population of natural killer cells in mice with severe combined immunodeficiency (SCID) lack rearrangement and expression of T cell receptor genes. The Journal of Experimental Medicine. 164: 1797-802. PMID 3772298 DOI: 10.1084/Jem.164.5.1797 |
0.371 |
|
| 1986 |
Lauzon RJ, Siminovitch KA, Roder JC. T cell receptor gene rearrangements in cells with natural killer activity in the mouse. Immunologic Research. 5: 191-200. PMID 3553372 DOI: 10.1007/Bf02919200 |
0.364 |
|
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