| Year |
Citation |
Score |
| 2023 |
Jenkins KA, Park M, Pederzoli-Ribeil M, Eskiocak U, Johnson P, Guzman W, McLaughlin M, Moore-Lai D, O'Toole C, Liu Z, Nicholson B, Flesch V, Qiu H, Clackson T, O'Hagan RC, ... ... Williams JC, et al. XTX101, a tumor-activated, Fc-enhanced anti-CTLA-4 monoclonal antibody, demonstrates tumor-growth inhibition and tumor-selective pharmacodynamics in mouse models of cancer. Journal For Immunotherapy of Cancer. 11. PMID 38164757 DOI: 10.1136/jitc-2023-007785 |
0.766 |
|
| 2022 |
Zhang C, Guo C, Russell RW, Quinn CM, Li M, Williams JC, Gronenborn AM, Polenova T. Magic-angle-spinning NMR structure of the kinesin-1 motor domain assembled with microtubules reveals the elusive neck linker orientation. Nature Communications. 13: 6795. PMID 36357375 DOI: 10.1038/s41467-022-34026-w |
0.687 |
|
| 2022 |
Kuo YC, Kuo CF, Jenkins K, Hung AF, Chang WC, Park M, Aguilar B, Starr R, Hibbard J, Brown C, Williams JC. Antibody-based redirection of universal Fabrack-CAR T cells selectively kill antigen bearing tumor cells. Journal For Immunotherapy of Cancer. 10. PMID 35728874 DOI: 10.1136/jitc-2021-003752 |
0.768 |
|
| 2020 |
Kuo Y, King JD, Kuo C, Kenyon V, Park M, Chang W, Stern L, Brown CE, Williams JC. Abstract 6591: Antibody-based redirection of meditope-CAR T cells selectively kill antigen bearing tumor cells Immunology. DOI: 10.1158/1538-7445.Am2020-6591 |
0.309 |
|
| 2019 |
Guo C, Williams JC, Polenova T. Conformational Flexibility of p150(1-191) Subunit of Dynactin Assembled with Microtubules. Biophysical Journal. PMID 31445682 DOI: 10.1016/J.Bpj.2019.07.036 |
0.632 |
|
| 2019 |
Mutsvunguma LZ, Rodriguez E, Escalante GM, Muniraju M, Williams JC, Warden C, Qin H, Wang J, Wu X, Barasa A, Mulama DH, Mwangi W, Ogembo JG. Identification of multiple potent neutralizing and non-neutralizing antibodies against Epstein-Barr virus gp350 protein with potential for clinical application and as reagents for mapping immunodominant epitopes. Virology. 536: 1-15. PMID 31377598 DOI: 10.1016/J.Virol.2019.07.026 |
0.304 |
|
| 2019 |
King JD, Williams JC. Refining the Quality of Monoclonal Antibodies: Grafting Unique Peptide-Binding Site in the Fab Framework. Methods in Molecular Biology (Clifton, N.J.). 1904: 293-298. PMID 30539475 DOI: 10.1007/978-1-4939-8958-4_12 |
0.381 |
|
| 2018 |
Golfetto O, Wakefield DL, Cacao EE, Avery KN, Kenyon V, Jorand R, Tobin SJ, Biswas S, Gutierrez J, Clinton R, Ma Y, Horne DA, Williams JC, Jovanović-Talisman T. A Platform To Enhance Quantitative Single Molecule Localization Microscopy. Journal of the American Chemical Society. PMID 30256630 DOI: 10.1021/Jacs.8B04939 |
0.331 |
|
| 2018 |
King JD, Ma Y, Kuo YC, Bzymek KP, Goodstein LH, Meyer K, Moore RE, Crow D, Colcher D, Singh G, Horne DA, Williams JC. Template-catalyzed, disulfide conjugation of monoclonal antibodies using a natural amino acid tag. Bioconjugate Chemistry. PMID 29763554 DOI: 10.1021/Acs.Bioconjchem.8B00284 |
0.317 |
|
| 2018 |
Bzymek KP, Puckett JW, Zer C, Xie J, Ma Y, King JD, Goodstein LH, Avery KN, Colcher D, Singh G, Horne DA, Williams JC. Mechanically interlocked functionalization of monoclonal antibodies. Nature Communications. 9: 1580. PMID 29679060 DOI: 10.1038/S41467-018-03976-5 |
0.34 |
|
| 2018 |
Karow M, Jenkins K, Park M, Johnson P, Gonzalez A, Flesch V, Miles T, Rodeck U, Williams JC. Pre-clinical assessment of rational design immuno-oncology biologics with improved therapeutic indices. Journal of Clinical Oncology. 36. DOI: 10.1200/Jco.2018.36.15_Suppl.E15096 |
0.753 |
|
| 2017 |
Bzymek KP, Ma Y, Avery KN, Horne DA, Williams JC. Meditope-Fab interaction: threading the hole. Acta Crystallographica. Section F, Structural Biology Communications. 73: 688-694. PMID 29199990 DOI: 10.1107/S2053230X17016272 |
0.395 |
|
| 2017 |
Herrmann A, Lahtz C, Nagao T, Song JY, Chan WC, Lee H, Yue C, Look T, Muelfarth R, Li W, Jenkins K, Williams J, Budde LE, Forman SJ, Kwak LW, et al. CTLA4 promotes Tyk2-STAT3 dependent B cell oncogenecity. Cancer Research. PMID 28716895 DOI: 10.1158/0008-5472.Can-16-0342 |
0.774 |
|
| 2017 |
Zer C, Avery KN, Meyer K, Goodstein L, Bzymek KP, Singh G, Williams JC. Engineering a high-affinity peptide binding site into the anti-CEA mAb M5A. Protein Engineering, Design & Selection : Peds. 1-9. PMID 28431161 DOI: 10.1093/Protein/Gzx016 |
0.358 |
|
| 2017 |
Roberts CM, Shahin SA, Loeza J, Dellinger TH, Williams JC, Glackin CA. Disruption of TWIST1-RELA binding by mutation and competitive inhibition to validate the TWIST1 WR domain as a therapeutic target. Bmc Cancer. 17: 184. PMID 28283022 DOI: 10.1186/S12885-017-3169-9 |
0.351 |
|
| 2017 |
Golfetto O, Wakefield DL, Cacao EE, Avery KN, Jorand R, Tobin SJ, Clinton RM, Gutierrez J, Ma Y, Ganjali D, Sideris A, Horne DA, Williams JC, Jovanovic-Talisman T. A Quantitative Platform for Super-Resolution Microscopy Imaging Biophysical Journal. 112: 143a. DOI: 10.1016/J.Bpj.2016.11.788 |
0.302 |
|
| 2016 |
Bzymek KP, Avery KA, Ma Y, Horne DA, Williams JC. Natural and non-natural amino-acid side-chain substitutions: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallographica. Section F, Structural Biology Communications. 72: 820-830. PMID 27834791 DOI: 10.1107/S2053230X16016149 |
0.334 |
|
| 2016 |
Bzymek KP, Ma Y, Avery KA, Horne DA, Williams JC. Cyclization strategies of meditopes: affinity and diffraction studies of meditope-Fab complexes. Acta Crystallographica. Section F, Structural Biology Communications. 72: 434-442. PMID 27303895 DOI: 10.1107/S2053230X16007202 |
0.326 |
|
| 2016 |
Dumitru CD, Matho M, Gardiner E, Williams JC, Bzymek K. Abstract 869: Meditope enablement and structural analysis of anti-CD33 antibodies Cancer Research. 76: 869-869. DOI: 10.1158/1538-7445.Am2016-869 |
0.361 |
|
| 2016 |
Dumitru CD, Gardiner E, Williams J, Zer C. Abstract 598: Utilization of Meditope Biosciences SnAP technology to enhance antibody internalization Cancer Research. 76: 598-598. DOI: 10.1158/1538-7445.Am2016-598 |
0.33 |
|
| 2015 |
Yan S, Guo C, Hou G, Zhang H, Lu X, Williams JC, Polenova T. Atomic-resolution structure of the CAP-Gly domain of dynactin on polymeric microtubules determined by magic angle spinning NMR spectroscopy. Proceedings of the National Academy of Sciences of the United States of America. 112: 14611-6. PMID 26604305 DOI: 10.1073/Pnas.1509852112 |
0.625 |
|
| 2015 |
Avery KN, Zer C, Bzymek KP, Williams JC. Development of a high affinity, non-covalent biologic to add functionality to Fabs. Scientific Reports. 5: 7817. PMID 25588710 DOI: 10.1038/Srep07817 |
0.357 |
|
| 2015 |
Küçük C, Jiang B, Hu X, Zhang W, Chan JK, Xiao W, Lack N, Alkan C, Williams JC, Avery KN, Kavak P, Scuto A, Sen E, Gaulard P, Staudt L, et al. Activating mutations of STAT5B and STAT3 in lymphomas derived from γδ-T or NK cells. Nature Communications. 6: 6025. PMID 25586472 DOI: 10.1038/Ncomms7025 |
0.363 |
|
| 2015 |
Yan S, Zhang H, Hou G, Ahmed S, Williams JC, Polenova T. Internal dynamics of dynactin CAP-Gly is regulated by microtubules and plus end tracking protein EB1. The Journal of Biological Chemistry. 290: 1607-22. PMID 25451937 DOI: 10.1074/Jbc.M114.603118 |
0.765 |
|
| 2015 |
Golfetto O, Cacao EE, Jorand R, Biswas S, Zer C, Avery KN, Williams JC, Jovanovic-Talisman T. Quantitative Super-Resolution Microscopy using Novel Meditope Reagents Biophysical Journal. 108: 479a. DOI: 10.1016/J.Bpj.2014.11.2618 |
0.374 |
|
| 2014 |
Ahmed S, Xie J, Horne D, Williams JC. Photocleavable dimerizer for the rapid reversal of molecular trap antagonists. The Journal of Biological Chemistry. 289: 4546-52. PMID 24421317 DOI: 10.1074/Jbc.C113.513622 |
0.706 |
|
| 2013 |
Donaldson JM, Zer C, Avery KN, Bzymek KP, Horne DA, Williams JC. Identification and grafting of a unique peptide-binding site in the Fab framework of monoclonal antibodies. Proceedings of the National Academy of Sciences of the United States of America. 110: 17456-61. PMID 24101516 DOI: 10.1073/Pnas.1307309110 |
0.769 |
|
| 2013 |
Yan S, Hou G, Schwieters CD, Ahmed S, Williams JC, Polenova T. Three-dimensional structure of CAP-gly domain of mammalian dynactin determined by magic angle spinning NMR spectroscopy: conformational plasticity and interactions with end-binding protein EB1. Journal of Molecular Biology. 425: 4249-66. PMID 23648839 DOI: 10.1016/J.Jmb.2013.04.027 |
0.788 |
|
| 2013 |
Siglin AE, Sun S, Moore JK, Tan S, Poenie M, Lear JD, Polenova T, Cooper JA, Williams JC. Dynein and dynactin leverage their bivalent character to form a high-affinity interaction. Plos One. 8: e59453. PMID 23577064 DOI: 10.1371/Journal.Pone.0059453 |
0.777 |
|
| 2012 |
Sun S, Yan S, Guo C, Li M, Hoch JC, Williams JC, Polenova T. A time-saving strategy for MAS NMR spectroscopy by combining nonuniform sampling and paramagnetic relaxation assisted condensed data collection. The Journal of Physical Chemistry. B. 116: 13585-96. PMID 23094591 DOI: 10.1021/Jp3005794 |
0.525 |
|
| 2012 |
Sun S, Han Y, Paramasivam S, Yan S, Siglin AE, Williams JC, Byeon IJ, Ahn J, Gronenborn AM, Polenova T. Solid-state NMR spectroscopy of protein complexes. Methods in Molecular Biology (Clifton, N.J.). 831: 303-31. PMID 22167681 DOI: 10.1007/978-1-61779-480-3_17 |
0.764 |
|
| 2011 |
Sun S, Butterworth AH, Paramasivam S, Yan S, Lightcap CM, Williams JC, Polenova T. Resonance Assignments and Secondary Structure Analysis of Dynein Light Chain 8 by Magic Angle Spinning NMR Spectroscopy. Canadian Journal of Chemistry. 89: 909-918. PMID 23243318 DOI: 10.1139/V11-030 |
0.77 |
|
| 2011 |
Stuchell-Brereton MD, Siglin A, Li J, Moore JK, Ahmed S, Williams JC, Cooper JA. Functional interaction between dynein light chain and intermediate chain is required for mitotic spindle positioning. Molecular Biology of the Cell. 22: 2690-701. PMID 21633107 DOI: 10.1091/Mbc.E11-01-0075 |
0.773 |
|
| 2011 |
Buettner R, Corzano R, Rashid R, Lin J, Senthil M, Hedvat M, Schroeder A, Mao A, Herrmann A, Yim J, Li H, Yuan YC, Yakushijin K, Yakushijin F, Vaidehi N, ... ... Williams JC, et al. Alkylation of cysteine 468 in Stat3 defines a novel site for therapeutic development. Acs Chemical Biology. 6: 432-43. PMID 21226522 DOI: 10.1021/Cb100253E |
0.759 |
|
| 2011 |
Buettner RR, Corzano R, Lin J, Vaidehi N, Yip R, Chen Y, Jove R, Horne D, Williams J. Abstract 2576: Mechanism of action of a novel Stat3 inhibitor for cancer therapy Cancer Research. 71: 2576-2576. DOI: 10.1158/1538-7445.Am2011-2576 |
0.756 |
|
| 2010 |
Ahmed S, Sun S, Siglin AE, Polenova T, Williams JC. Disease-associated mutations in the p150(Glued) subunit destabilize the CAP-gly domain. Biochemistry. 49: 5083-5. PMID 20518521 DOI: 10.1021/Bi100235Z |
0.754 |
|
| 2010 |
Varma D, Dawn A, Ghosh-Roy A, Weil SJ, Ori-McKenney KM, Zhao Y, Keen J, Vallee RB, Williams JC. Development and application of in vivo molecular traps reveals that dynein light chain occupancy differentially affects dynein-mediated processes. Proceedings of the National Academy of Sciences of the United States of America. 107: 3493-8. PMID 20133681 DOI: 10.1073/Pnas.0908959107 |
0.389 |
|
| 2010 |
WILLIAMS JC, MCDERMOTT AE. ChemInform Abstract: cis-trans Energetics in Urea and Acetamide Studied by Deuterium NMR. Cheminform. 25: no-no. DOI: 10.1002/CHIN.199408054 |
0.452 |
|
| 2009 |
Donaldson JM, Kari C, Fragoso RC, Rodeck U, Williams JC. Design and development of masked therapeutic antibodies to limit off-target effects: application to anti-EGFR antibodies. Cancer Biology & Therapy. 8: 2147-52. PMID 19783899 |
0.745 |
|
| 2009 |
Kang DS, Kern RC, Puthenveedu MA, von Zastrow M, Williams JC, Benovic JL. Structure of an arrestin2-clathrin complex reveals a novel clathrin binding domain that modulates receptor trafficking. The Journal of Biological Chemistry. 284: 29860-72. PMID 19710023 DOI: 10.1074/Jbc.M109.023366 |
0.403 |
|
| 2009 |
Sun S, Siglin A, Williams JC, Polenova T. Solid-state and solution NMR studies of the CAP-Gly domain of mammalian dynactin and its interaction with microtubules. Journal of the American Chemical Society. 131: 10113-26. PMID 19580321 DOI: 10.1021/Ja902003U |
0.786 |
|
| 2009 |
Lightcap CM, Kari G, Arias-Romero LE, Chernoff J, Rodeck U, Williams JC. Interaction with LC8 is required for Pak1 nuclear import and is indispensable for zebrafish development. Plos One. 4: e6025. PMID 19557173 DOI: 10.1371/Journal.Pone.0006025 |
0.784 |
|
| 2009 |
Höök P, Yagi T, Ghosh-Roy A, Williams JC, Vallee RB. The dynein stalk contains an antiparallel coiled coil with region-specific stability. Biochemistry. 48: 2710-3. PMID 19222235 DOI: 10.1021/Bi900223X |
0.346 |
|
| 2008 |
Lightcap CM, Sun S, Lear JD, Rodeck U, Polenova T, Williams JC. Biochemical and structural characterization of the Pak1-LC8 interaction. The Journal of Biological Chemistry. 283: 27314-24. PMID 18650427 DOI: 10.1074/Jbc.M800758200 |
0.783 |
|
| 2008 |
Kamat V, Donaldson JM, Kari C, Quadros MR, Lelkes PI, Chaiken I, Cocklin S, Williams JC, Papazoglou E, Rodeck U. Enhanced EGFR inhibition and distinct epitope recognition by EGFR antagonistic mAbs C225 and 425. Cancer Biology & Therapy. 7: 726-33. PMID 18424917 DOI: 10.4161/Cbt.7.5.6097 |
0.76 |
|
| 2007 |
Williams JC, Roulhac PL, Roy AG, Vallee RB, Fitzgerald MC, Hendrickson WA. Structural and thermodynamic characterization of a cytoplasmic dynein light chain-intermediate chain complex. Proceedings of the National Academy of Sciences of the United States of America. 104: 10028-33. PMID 17551010 DOI: 10.1073/Pnas.0703614104 |
0.578 |
|
| 2005 |
Williams JC, Xie H, Hendrickson WA. Crystal structure of dynein light chain TcTex-1 Journal of Biological Chemistry. 280: 21981-21986. PMID 15701632 DOI: 10.1074/Jbc.M414643200 |
0.578 |
|
| 2005 |
Williams JC, Sue C, Banting GB, Yang H, Glerum DM, Hendrickson WA, Schon EA. Crystal structure of human SCO1: Implications for redox signaling by a mitochondrial cytochrome c oxidase "assembly" protein Journal of Biological Chemistry. 280: 15202-15211. PMID 15659396 DOI: 10.1074/Jbc.M410705200 |
0.493 |
|
| 1998 |
Williams JC, Wierenga RK, Saraste M. Insights into Src kinase functions: structural comparisons. Trends in Biochemical Sciences. 23: 179-84. PMID 9612082 DOI: 10.1016/S0968-0004(98)01202-X |
0.526 |
|
| 1996 |
Williams JC, Weijland A, Courtneidge SA, Superti-Furga G, Wierenga RK. Preliminary diffraction studies of the regulated form of chicken SRC protein tyrosine kinase Acta Crystallographica Section a Foundations of Crystallography. 52: C582-C582. DOI: 10.1107/S0108767396076350 |
0.496 |
|
| 1995 |
Williams JC, McDermott AE. Dynamics of the flexible loop of triosephosphate isomerase: the loop motion is not ligand gated. Biochemistry. 34: 8309-19. PMID 7599123 DOI: 10.1021/Bi00026A012 |
0.564 |
|
| 1994 |
Copié V, McDermott AE, Beshah K, Williams JC, Spijker-Assink M, Gebhard R, Lugtenburg J, Herzfeld J, Griffin RG. Deuterium solid-state nuclear magnetic resonance studies of methyl group dynamics in bacteriorhodopsin and retinal model compounds: evidence for a 6-s-trans chromophore in the protein. Biochemistry. 33: 3280-6. PMID 8136363 DOI: 10.1021/Bi00177A019 |
0.624 |
|
| 1993 |
Williams JC, McDermott AE. Cis-trans energetics in urea and acetamide studied by deuterium NMR Journal of Physical Chemistry. 97: 12393-12398. DOI: 10.1021/J100149A047 |
0.521 |
|
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